LOCUS       c00112_gnlPro..        16021 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JFGEHPLK_112.
ACCESSION   c00112_gnlPro..
VERSION     c00112_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 20:44:46
            Original ID  :: gnl|Prokka|JFGEHPLK_112
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16021
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16021
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[53:6021]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      54..6021
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..16021
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16021
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(54..1097)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg112_1"
                     /sec_met_domain="IlvN (E-value: 8.9e-47, bitscore: 150.6,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 1.2e-39, bitscore: 127.8,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQMNFGGVVENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQ
                     SLNLRDNGFNVIVGQRQGKTYDKAVEDGWVPGETLFGIEEACDKATIIMCLLSDAAVMS
                     VWPTMKPYLTAGKALYFSHGFAITWNDRTGVVPPADIDVIMVAPKGSGTSLRSMFLEGR
                     GLNSSFAIYQDATGKAMDRTLALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMG
                     PFHDAIKPVVEKLYANVKCGNEAQISIDSNSKPDYREKLEAELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(1147..1872)
                     /locus_tag="ctg112_2"
                     /transl_table=11
                     /translation="MEKVGLFHFVAEPYLMDFRGRVTLPMIGNYLIHAASSHAGERGFG
                     FNDMSERHTAWVLSRLAIEMKEYPTAFDKINLYTWIDEVGRLFTSRCFELADENGKTFG
                     FARSIWAAIDVETRRPTLLDIEALGKYIDERPCPIEKPGKIMPAENKAEGIPYSIKYSD
                     LDINGHFNSVKYIEHLLDLFDIDQFKTREIGRLEIAYQSEGKQGMPLTLHKAESAPDKQ
                     DMAICHEGKAICRAAVTWR"
     CDS             complement(1879..2433)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg112_3"
                     /sec_met_domain="ALS_ss_C (E-value: 6.7e-17, bitscore:
                     53.4, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTKKLYTVIIFSENIVGLLNQITIIFTRRQLNIETLSVSPSAIK
                     GIHKFTITTFADEDMIDKVVKQIDKRVDILKAYYNTDEDLVYQEIALYKLSTELFIKMG
                     TVEGLIRKYNARILEMNETCVVLEKSGHYDETQALFNELSETIGVLQFIRSGRVAITKS
                     KVERLSDMLADMERKLQEKQQ"
     CDS             complement(2449..4152)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg112_4"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.7e-50, bitscore:
                     161.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKQKITGSEALLKALIAEGVDTIFGYPGGQAIPIYDSLYDYRDQ
                     LRHVLVRHEQGATHAAQGYARVSGKVGVTLVTSGPGATNTITGIADALMDSTPMVVIAG
                     QVPSPLLGTDAFQEVDVIGITQPITKWAYQIRKPEEIAWAVSRAFYIASTGRPGPVVLD
                     LAKDAQVGLVEYEYKKVDYVRSYQPEPDINKDRIKAAADLINEAKKPFCLVGQGVLLGG
                     AEEELKAFLQKNDIPAGSTVLGLSALPTDFPLNKGMLGMHGNVGPNRKTNECDVLIAIG
                     MRFDDRVTGDLKTYAKQAKIIHLDIDNSEIGKNVAVDVKVLGNAKHTIPMITALLEERK
                     RPEWNAEFDRDEKEEYDKVIEKELYPTEGQLKMGEVVRKVSEATGNDAVLVTDVGQNQM
                     MGVRYFKYKQTRSVVTSGGLGTMGFGLPAAMGAKFGAPDRTVCFFTGDGGMQMTIQELG
                     TIMQEKLNVKIIILNNNFLGMVRQWQELFFHERYSNTIMENPDFVAIAKAYGIAGRAVE
                     KREELDDAIAEMLNHDGAYVLVANVETCGMVYPMVPAGGSVTNMIMGDEK"
     CDS             complement(4186..6021)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg112_5"
                     /sec_met_domain="ILVD_EDD (E-value: 1.6e-216, bitscore:
                     711.6, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNPLRSSFSTEGRRMAGARALWRANGMKEEQFGKPIIAIVNSFT
                     QFVPGHTHLHEIGQLVKAEIEKQGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMASMRLNIPTVFVSGGPMEAGELDGRHLDLID
                     AMIESADTSVSDERIEQVERHACPGCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     KNRIQLFRDAAKQIVENAYKYYRDGDDSVLPRNIATRQAFLNAMSLDIAMGGSTNTVLH
                     LLAVAQEAGADFHMEDIDMLSRKTPCLCKVAPNTHTYHVQDVNRAGGILGIMNELMKAG
                     LVDGSTRRADGLTLAEAVDKYAVTSPNVTEEAIRKYKSAPAHRFSIQMGSQESYYKELD
                     TDRAEGCIRDVEHAYSKDGGLAVLRGNIALDGCVVKTAGVDESIWKFSGPAKVFDSQDA
                     ACEGILGGKVVSGDVVVITYEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGG
                     TSGLSIGHISPEAASGGAIGLVRDGDIIEINIPERSINVRLSDEELAERRKAEEARGKK
                     AFTPPTRQREVSKALRAYGKMVSSADKGGVRIVED"
     CDS             7151..7735
                     /locus_tag="ctg112_6"
                     /transl_table=11
                     /translation="MGERNKHIENLRKGNRSSFEYLYTVWSGKLYNFVMKISHGDSYLA
                     EEMVQTVFLKVWKNREQLDPKLSFGAYLCTIAKNLLTNHYQHKMMEILYIEQQIDHPGT
                     PYARGTDEIVEYHLLEEFVDSLIQQMPEGRQRIYKLSRQSHLSNREIADQLQISENTVE
                     SQLTKAISFLRKRLKDQYDLGLLALSCLLNS"
     CDS             7735..7851
                     /locus_tag="ctg112_7"
                     /transl_table=11
                     /translation="MNTKSTGCDNGNFPVICILNKDRGKWKETITYIYLTSS"
     CDS             7809..8840
                     /locus_tag="ctg112_8"
                     /transl_table=11
                     /translation="MERNDYIHIFNKFLENKATPSEIKLLIEWLKERKAFDTWADDIWM
                     QSPMEMDPSVKQHLLDELRKQIFFKETGKRTFMSLSLPSLFHYALRITAIILLLITTSI
                     VTYHYAMDKQREPMDMIVAVEKGQKANITLPDGSKGWINSDSKLSYGSRFNADERVLNL
                     EGEAYFEVKPDAKRPFIVQSGKVSVKALGTSFNVKNYNTEEHISVVLMTGKVEVTANDN
                     HVDLLPNEQAIFNKHSSILGKNKVDNSLDYSSWMYNTLNFESTPFSEIAHTLERYYNTQ
                     IVFKSEALKSYRFTGKPGNTSLASILHLLSLTSPLAYEIKDSVVILYENNDKKELYNRV
                     LKQ"
     CDS             8980..12480
                     /locus_tag="ctg112_9"
                     /transl_table=11
                     /translation="MKKKLVRVSQYIKIRSIKTVGLALFSSLILAPSLYAQISLDVQDQ
                     SIRHILKEIEKAGEYKFFYNSDLSNLDHKTSISVQDKNIDEVMSLLLANTEISYKKEAN
                     NMIVLTVKSSSSSQAPRKTRKITGTVVDPDGLPIIGANVIEQGTTNGSITDLDGKFELI
                     ITENAILNISYIGFSDKQITVKEETSLQVTMTEDTQKLDEIVVVGYGVQKKVNLTGSVS
                     AVKGEELSQRPVANATQSLQGLVPGLTVSNSNSGRPGASGALSLRGQGNLANTANPYVL
                     VDGVEMDLADVNPNDIESISVLKDAASAAIYGARAAYGVILVTTKKGEEGKMRISYQGT
                     VGWSSPTVMPEMANAYDYATFFNQACTNANVIKQYNPEKLQQLQQYMKDPASVNPWAEL
                     NGENNLIGAFENTPKGLGNVDYFDLHYKNSAFKQNHNLSLSGGGKKAQYYISTGMYTED
                     GILRYADIKYKRLNFNANIASQITDWLNLKVNTKFMNSDNDTPFGKGALSEGFYHSLAR
                     FRPTISPIDPNGHFTELTMIPYLQSGTYTNTQKNNLTLTGGLEAQPIKNWRIFFDYTYR
                     QNNENYEALNVAPMIPGADNETLYKGTRQELGVMENGQFTRSSALSQYQSINLYSNYMF
                     SLADKHNFTVMAGYQEENYAYSYLYESVTDMISTNNPGLNLGTGEKSTTDTRNGWATRG
                     FFGRINYDYDGRYLLEVNGRYDGSSRFASDHRWGFFPSVSLGWNITRESFMEKSLEVLS
                     NLKLRASWGLLGNQSGAGLYTFTSIMGIQPLGNWYFQDGRDMYINAPGVIDPFTTWEKV
                     ESKNLGLDFGFFNNALTGTFDVFQRDTKDMLGPSADLADFFGAEAPNTNNARMRNRGWE
                     LSLQYRGKIGKDIHYSIGGSLADATSEVTAYENPTGTNPQDNWYVGKKVGEIWGYKASG
                     LLQTQEEADTYNNTYDLSFLSGQKWMPGDVKYMDLNNDKKINNGNNTLEDMGDMCVIGN
                     TTPRYQYTLNGSISWKGISLSMMFQGIGKRNWSPDLGTVYFWGSGAYAQVTVFNDHLDY
                     WTPENPDAYYPNPYTGAAGSINQFRNKTSQKSDRYMQSAAYCRLKNLTISYDLPNSWSQ
                     KIGLSKAQVFFSGENLLTFTKLPSMFDPEAIFTGNDYTSEAGKNYPMNKVLSIGVIVNL
                     "
     CDS             12558..14324
                     /locus_tag="ctg112_10"
                     /transl_table=11
                     /translation="MDKYPEGELSSVNSFTSTTEITKYLNQFYESTLKINDKDVANSAI
                     KVQSNSIGNPTGIAFGDLNSDNMQSNVIDTRLAGETTLSSAVELTEYKHIRSLNFLINN
                     LDNCEEIGPEMEQCIGEAYFFRACYYYRLFVNYGEVTWLTKVLDPIQEQMERPRNSRLE
                     VADSILADLDIAIEHLNTQTNSSTMRVHKDVARALKSEVALFEGTWEKYHRAKNTPFYD
                     KKVTDEKISSYLRQAADAAKDVIDEGVWSISKGDPNTAYRDLFITLDLSHNPEVLWWKK
                     YDAANNIGHSVTRYLNKGGGTCGASASLVDDYLTKEGKPFVGSERDKAKVMYGDELSPD
                     LRDPRLSQTICMPGQDLRPNGEFVFKLPPLNEESRNQNTTGYSILKYVEYNTTYIPTID
                     GEGKSQAPAIQFRYADILLNYAEALAELDGAANASKIKEALRPLRERVGMPEMDFDREF
                     NTDPDYPFNKLDKYIQAVRRERRIEKALEGSRLQDILRWAAADILIIGKTPTGALFKGS
                     SLETAYGESLQEGENLFLTGTPSDSKRYIIPFNNKHYPNGWQFNPERDYLLPIQPRMLS
                     LTGNQWVQNPGW"
ORIGIN
        1 ccacccgtaa gtgacccgcc tctttttgct gatatataag gattaagatt ggattagttg
       61 ttctccggac gaagcttgcg tacagtaaca gctgtctgcc acatctcgct ctcgcgcaat
      121 gccttcaatt cagcctccaa tttctcacga taatccggct tagagtttga gtcgatagag
      181 atctgagcct cgttaccgca ttttacgttc gcatacaatt tctcgacaac cggcttgatt
      241 gcgtcgtgga acggacccat ccagtccaaa gcgccacgct gggcagtcgt agagcagtta
      301 gcgtacatcc agtccatacc attcttggcg aataaaggca tcaaggattg agtcaactcc
      361 tcgaccgtct cgttgaaagc ctcagaagga gtgtgtccat tctcgcgcaa tacctcatac
      421 tgggccaaca acaaaccttg gatagcgccc atcaaagaac cacgctcacc agtcaaatcg
      481 gaagtagcct cacggatgaa agtcgtctcg aacaagtagc cggaaccgat accgataccc
      541 aacgccaacg tacgatccat cgccttgcca gtagcgtctt gatagatagc gaaagaagag
      601 ttcaagccac gaccctcaag gaacatggaa cgcaaagacg taccagatcc cttcggagcg
      661 accatgatca cgtcaatatc cgcgggagga acaacgcccg tacgatcgtt ccaagtgatc
      721 gcgaaaccat gagagaaata cagggccttg ccagctgtca aataaggctt catcgtaggc
      781 catacagaca ttacggcagc gtcggacaat aagcacatga tgatcgtggc cttgtcgcaa
      841 gcctcctcga taccgaacag agtctcaccc ggaacccatc cgtcctcaac cgctttatcg
      901 taagtcttac cttggcgctg gccaacgatt acgttgaaac cattgtcacg aaggttcaat
      961 gactgtcccg gtccctgtac gccatagccg atcacagcga ttgtctcatc ttttaagatc
     1021 tctcttgcct tttccaacgg aaattcctcg cgggtcatta cattctctac aacaccgcca
     1081 aaattcattt gtgccatttt ctttttaact attaatgttt aaaaacctat ttatgtatct
     1141 cttttattat ctccaagtaa ccgccgcacg acagatcgcc tttccctcat ggcaaatagc
     1201 catgtcttgc ttatcgggag cggactccgc cttatgaagc gtaagcggca taccttgttt
     1261 gccctcggat tggtaggcga tctccagacg gccgatctca cgggtcttga actggtcgat
     1321 atcgaacaaa tccagcaggt gctcgatata cttcacgcta ttgaagtgac cgttgatatc
     1381 caagtcgctg tatttgatcg aatacgggat tccctccgcc ttattctccg ccggcatgat
     1441 cttgcccggc ttctcgatcg ggcacggacg ctcgtcgata tatttgccca atgcctctat
     1501 atccaataag gtaggacggc gggtctccac atcgatagcc gcccagatag aacgggcgaa
     1561 tccaaaggtt ttcccattct catccgccag ctcaaaacaa cgactggtga agaggcgtcc
     1621 gacctcatcg atccaagtgt ataaattaat cttatcgaag gcggtaggat attccttcat
     1681 ctcgatagcc agacgggaca acacccaagc cgtatgacgc tccgacatat cattgaaacc
     1741 gaacccacgc tctccggcat ggctggaagc ggcgtgaatc aaatagttac caatcatagg
     1801 gagcgttaca cgtcccctaa aatccatcaa atatggctcc gccacgaaat gaaataatcc
     1861 tactttctcc atatcttatt attgttgctt ttcctgtaac tttcgctcca tatcggccaa
     1921 catatcgctc aagcgctcca ccttgctctt cgtgatagcc acacgtccgg agcggatgaa
     1981 ttgcaggaca ccgatcgtct cgctcaactc attgaacaag gcctgtgtct cgtcatagtg
     2041 gccactcttc tccaatacca cgcaggtctc gttcatctcc aagatacggg cgttgtattt
     2101 acggatcaat ccctccacgg ttcccatctt gatgaaaagc tcggtactta gcttataaag
     2161 agcgatctct tgataaacca gatcctcatc cgtattataa taagccttca aaatatccac
     2221 acgtttatcg atctgtttca ccaccttatc gatcatatcc tcatcggcga atgtcgtgat
     2281 cgtaaactta tggatgccct tgatagcgga cggagagacg gacagagtct cgatgttcag
     2341 ctgtcggcgt gtaaagataa tcgttatctg gttcaaaaga cctacgatat tctctgaaaa
     2401 gataataacg gtatataatt tctttgttgt catagcttca tctcctcctt atttctcgtc
     2461 tcccataatc atgtttgtca cgcttccccc ggcaggaacc atcggatata ccattccgca
     2521 agtctccacg ttagcgacca acacgtaagc gccgtcgtgg tttagcatct cagcgatagc
     2581 gtcgtccaat tcctcccgct tttcaacggc acgaccggcg ataccatagg ctttagcgat
     2641 cgccacgaaa tccggattct ccatgatggt gtttgaataa cgctcgtgga agaacaattc
     2701 ttgccactga cgtaccatac ctaagaagtt attattaaga atgataatct tcacgttcag
     2761 tttctcctgc atgatagtgc ccaattcctg aatcgtcatc tgcatacccc catcaccggt
     2821 aaagaagcag accgtacggt ccggagcccc gaacttagcg cccatagcgg ccggcagacc
     2881 aaatcccatc gtacctaaac caccggaagt caccacgcta cgggtttgtt tatatttgaa
     2941 atagcggacg cccatcatct ggttctgccc aacgtcggtc accaatacag cgtcgttacc
     3001 ggtcgcctcg gaaaccttac ggactacctc gcccattttc agttggccct cggtcggata
     3061 caattccttc tcgattacct tatcgtattc ctctttctcg tcccgatcga actcggcatt
     3121 ccattccgga cgtttacgtt cttctaacaa cgccgtgatc atcggtatcg tgtgcttggc
     3181 attccccagc acctttacgt ccacggcaac attcttgccg atttccgagt tgtcgatatc
     3241 cagatggata atcttggctt gcttagcgta tgtctttaaa tcgccagtca cacggtcgtc
     3301 gaaacgcata ccgatagcga tcaatacatc acactcattc gttttccggt tcggccctac
     3361 gtttccatgc atgccgagca ttcccttgtt caatgggaaa tcggttggca acgcagataa
     3421 gcccaatacc gtagatccgg caggtatatc attcttttgg agaaacgctt tcaattcctc
     3481 ttccgcaccg cctaacaata ctccctgccc gaccagacag aagggtttct tcgcctcatt
     3541 gattaaatcg gcggcggcct tgatacgatc cttattgata tccggctccg gttgataact
     3601 acgtacgtaa tcgaccttct tatattcata ttccaccaac cctacttgcg catccttcgc
     3661 taaatccagc acaactggac ccggacggcc tgtagaagcg atataaaaag cacgagaaac
     3721 agcccatgcg atctcctccg gcttgcggat ttgataagcc catttcgtga tcggttgcgt
     3781 gatgccaatc acgtcgactt cctgaaaagc atcggttccc aacaacggcg agggtacttg
     3841 accggcgatt acgaccattg gcgtactatc catcagcgca tcagcgatac ccgtgatggt
     3901 attcgtagcg cccgggccgg aagtaaccaa cgtcactcct accttgccag atacacgggc
     3961 atatccttga gccgcatggg tagcgccttg ctcgtggcgc accaatacat gcctcaactg
     4021 gtccctataa tcatataaac tgtcgtaaat aggtatcgcc tgtccgccgg gataaccgaa
     4081 gatagtatct actccttcag caatcaacgc tttcagcaaa gcttccgaac cggttatctt
     4141 ttgtttctcc ataaaaaata acgtgtttaa tgtatattat tggctttaat cttcaacaat
     4201 ccttacacct cccttatcgg cggagctaac catcttcccg tacgctctca acgctttcga
     4261 gacctcacgc tgacgcgtcg gcggcgtaaa ggctttcttt ccacgtgcct cttccgcctt
     4321 acggcgctcg gccaactcct cgtcgctcaa ccgcacgttg atggaacgtt ccgggatatt
     4381 gatctcgatg atatccccgt ctctcaccag tccgatagcg ccaccggaag cggcctcggg
     4441 agagatatgc ccgatagaaa gaccggacgt accgccactg aaacgaccat ccgtgatcaa
     4501 ggcgcactcc ttacctaagt gacggctctt tatataagag gtaggatata acatctcttg
     4561 cattcccggc ccccctttcg gaccctcata cgtgatgacg accacatcgc ctgaaacgac
     4621 cttgcctcct aaaatgccct cgcaagcggc atcctgtgaa tcgaagactt tcgccgggcc
     4681 ggagaatttc caaatactct catccacacc ggcggttttt acgacacatc cgtccaaggc
     4741 gatattccct ctcaaaacag ccaagccgcc atccttggaa taagcgtgct ccacgtcacg
     4801 gatacaacct tcggcacgat ccgtatctaa ttctttataa taagattctt gggaacccat
     4861 ctggatactg aaccgatgag cgggagcgct cttgtattta cgaatcgcct cctccgttac
     4921 gttcggggaa gtgacggcgt atttatcaac agcctcggcc aaggtcaggc cgtccgcacg
     4981 tctcgtgctg ccatccacaa gcccggcttt catcaactcg ttcatgatac cgaggattcc
     5041 accggcacgg tttacgtctt gtacatgata agtgtgcgta ttcggggcta ccttacacag
     5101 gcaaggagtc ttgcgggata acatatcgat atcctccata tggaaatcgg cgccggcttc
     5161 ttgtgccacg gccaataagt gaagcaccgt attggtagac ccccccatgg cgatatccag
     5221 cgacatggcg ttcaagaaag cctgacgggt agcgatgttg cgaggtaaca cggaatcatc
     5281 cccgtcacga tagtatttgt aagcgttctc aacgatttgc ttagccgcgt cacggaaaag
     5341 ttggatacgg ttcttatggg tagccacgat cgtcccgtta cccggaagcg ccagaccgat
     5401 cgcctcgttc aagcagttca tagagttagc ggtaaacata ccggaacaac aaccgcaacc
     5461 cggacacgca tggcgttcca cctgctcgat acgctcatcg cttaccgatg tatcggcaga
     5521 ctcaatcatc gcgtcgatca aatcaagatg gcggccatcc agctcacctg cctccatcgg
     5581 gccaccggac acgaacaccg tcgggatatt taatcgcatg gaagccataa gcatacccgg
     5641 cgtgatctta tcgcaattgc tgatgcaaac catagcgtcc gccttatggg catttaccat
     5701 atattccacg ctgtccgcga taatgtcgcg tgaaggaagc gagtaaagca tcccatcgtg
     5761 ccccatagcg ataccgtcgt cgatagcgat cgtattaaat tcagcggcga aacaaccttg
     5821 tttctcgatc tcggccttga ccaattgccc gatctcatgc aaatgcgtat gccccggcac
     5881 gaactgggta aatgaattta cgatagcgat aataggcttg ccgaactgtt cctctttcat
     5941 cccgttggca cgccatagcg cacgggctcc ggccatccta cgaccttcgg tgctaaatga
     6001 gcttcttaac ggattcttca tctctttcct attttttgtt cgtagagcgc tttatccacg
     6061 cctctacctt gatttattta taataaaaaa gcctttccct atatggagaa aggcttaaga
     6121 aatatctcta cgacttcaca acttcttaca cacctttctc cttacctact aatgactaga
     6181 aggaccacca cgagaataat atgcaatacg ttgttcatca tcttttctta ttgtctttgt
     6241 ttgtttgacg ctgcaaatgt agaacaataa ttgatatgcg caaaggattt aaaagaaaat
     6301 tcttcatttt tctttcaatt ctcaagcaaa taccatttta ggattgcatt ttaacaggag
     6361 caagagtgta ttacttagga atcggaaggt atagaaggga aaaaacttcg atttccaaac
     6421 agaaacagta aaaagacaaa tgttatctaa aacagattcc agataacatt tttatcagat
     6481 aacacgactt acgataacac gtatctcata agaaaatcct attctagcga taaaaaagat
     6541 acatataaac tctaaatcac atatttatta acacttgtag actataaata gccttgaaaa
     6601 aattcataat agtgttctag aaaaaacata aggaagtttt ctgaagaaca taaggaagaa
     6661 atttcatcta gtatcggact aaattttgtt aacatttgaa tgaaaatcac ctaaaatcaa
     6721 gactaaatcc ggcataaccc acgctagaag cagctcaagc aaagacattt tcaaaatgac
     6781 tttcagacag agaaagcctt aaatactcaa ccgatagaca gctattcaaa catcaatcat
     6841 aaaaaagacc aacaacacct gcattcaaac atcattctga tttacacaac catcaaatgc
     6901 ttgcgctttt gccgtgcgac caagcccccg ccccataatt catcacccac agagagcaat
     6961 aataacactt tgacatttcg tcaacaaggt tcacatagaa aagtctatcc ccaccaaatt
     7021 tcataaaaaa gccccaatag cgaaacagga aatttatata gttccaagct agttcttaaa
     7081 taaaatttgc cctcctcaag aaaattagct aatatcgcga ctattcataa agttgttgat
     7141 ggattaatcc atgggagaga ggaacaagca tattgagaac cttagaaagg gtaatcgttc
     7201 atcttttgaa tatctttaca cggtttggag tggcaaatta tataattttg tcatgaaaat
     7261 ttctcatggg gattcctact tggcagagga aatggtacaa actgtatttc ttaaagtatg
     7321 gaaaaatcga gaacaattag acccaaaact gtcttttgga gcctatttat gtacgatagc
     7381 aaaaaactta ttaactaacc attaccaaca taaaatgatg gagattctct atatagaaca
     7441 acaaatcgac caccccggaa ctccttatgc cagaggtacg gacgagatcg tagaatatca
     7501 tctcctagaa gaattcgttg attctttaat acaacaaatg cccgaaggaa ggcaaagaat
     7561 ttataaacta agcagacaat cccacctatc caaccgggag atagcagacc aattgcagat
     7621 atcagagaat accgtggaat cccaactgac caaagccatc tcctttctac gcaaaaggtt
     7681 aaaagaccaa tacgacctag gacttttagc tttaagttgc ctccttaata gttaatgaat
     7741 actaaatcca caggatgcga taacggaaac ttccctgtca tttgtatact gaataaagac
     7801 agaggaaaat ggaaagaaac gattacatac atatatttaa caagttccta gagaataagg
     7861 caactccatc ggaaataaag ctattgatag aatggctaaa agaacgaaaa gcttttgaca
     7921 catgggctga tgatatatgg atgcaatccc cgatggaaat ggatccttca gtaaaacaac
     7981 atttactaga cgaactccgt aaacaaatct tttttaaaga aacagggaaa aggacattca
     8041 tgagtctttc tctcccttca cttttccatt atgcgctacg tatcacagca attatcctat
     8101 tgctcataac aacaagtatt gtcacctatc attatgcaat ggataaacag cgagaaccga
     8161 tggacatgat tgtcgctgtc gagaaaggac aaaaagcgaa tataacattg cctgatggtt
     8221 caaaaggatg gataaattca gattcaaagt tatcttatgg aagccgtttt aatgcagatg
     8281 aacgagttct gaatctagaa ggcgaagctt attttgaagt caagcccgat gctaaacgtc
     8341 cttttatcgt tcaatcggga aaagtatccg taaaagcttt aggaaccagt tttaacgtaa
     8401 agaactataa cacggaagag cacatatccg ttgtattaat gaccgggaaa gtagaagtaa
     8461 ccgcaaacga taaccatgta gacctgttgc ctaatgaaca agctattttc aataaacact
     8521 ctagcatact ggggaaaaac aaggttgaca atagtctaga ttactccagt tggatgtaca
     8581 atacattgaa ttttgagtca acaccattca gcgagattgc tcatacgctg gaacgttatt
     8641 acaataccca gatcgtattt aaatctgagg ccttaaagag ttatcgtttt acaggtaagc
     8701 ccgggaatac cagtctagcg agcatcttac atttattgtc tcttacctca ccattagcct
     8761 acgagataaa agacagtgtg gttattttgt atgagaacaa cgacaaaaaa gagttatata
     8821 acagagtatt aaaacagtaa atagcaattt catgaaaagc ccgtaaaaaa tcggggtaga
     8881 aatgctaggc atttcccccc gaaaaagaaa tcagttaacc gcgcttaggt atctcgcaaa
     8941 tagcaagcgc aagtactaat atccatagaa tacaaaagta tgaaaaaaaa acttgtccgt
     9001 gtatcacaat acataaaaat acggtcaatc aaaacagtcg gtctggcact attcagtagt
     9061 ttaatcttgg ctccttcact ttatgcccaa atttcactgg atgtacaaga ccaatccatc
     9121 cgtcacatat taaaagagat agaaaaggcg ggggaataca aattcttcta taacagtgat
     9181 ctaagtaacc tagatcacaa aacgtcaata tccgtacagg ataaaaacat tgatgaagtc
     9241 atgagcctat tattagccaa tacggaaata tcctataaaa aagaggccaa taatatgatt
     9301 gtattaacag ttaaatcatc ttcttcatcg caagctccga gaaagacaag aaaaataaca
     9361 ggaacagttg tagaccctga cggtttacca atcatcggag caaatgtaat cgagcagggt
     9421 acaacaaacg gttccattac ggatttggat ggaaaatttg aattaataat taccgaaaat
     9481 gccatcttaa atatctctta tatcggtttt tccgacaaac aaataacagt caaggaagaa
     9541 acctccttac aggttacaat gacggaagac acccagaagt tagatgagat agtagttgtt
     9601 ggatacggtg tacagaaaaa ggtaaacctt actggatctg tttctgccgt aaaaggcgaa
     9661 gaactcagcc aacgcccagt agctaacgca actcaaagtt tacaaggatt agtacccgga
     9721 ttaaccgtat ccaactccaa ctcaggtcgc ccgggagcta gtggagcatt gagtttacga
     9781 ggacaaggaa atttagcgaa cacagcgaat ccttatgtat tagttgacgg tgtagagatg
     9841 gatttggcag atgtaaaccc caatgatatt gaatcgattt ccgtcttaaa agatgccgct
     9901 tccgcagcta tttatggcgc ccgtgccgct tatggcgtaa ttttagttac gacgaaaaaa
     9961 ggtgaagaag gtaagatgcg catcagttat caaggtaccg taggatggag ttcccctact
    10021 gtaatgccgg aaatggctaa tgcttatgac tatgcgactt ttttcaatca agcttgtacc
    10081 aatgctaacg taatcaagca atataacccg gaaaaattac agcaacttca gcagtacatg
    10141 aaagatcctg ctagcgtaaa tccttgggca gagcttaatg gagaaaataa tctaataggg
    10201 gcattcgaaa acacaccaaa gggtttgggc aatgtggatt actttgattt acattataag
    10261 aactccgcat tcaaacaaaa ccataatttg agtctcagtg gaggtggcaa aaaagcgcaa
    10321 tattatatct ctaccggaat gtatacggaa gatggtattt taagatatgc ggacataaaa
    10381 tataaacgct taaatttcaa tgcaaatatc gcctctcaaa ttacggactg gctaaatttg
    10441 aaagttaata ctaaattcat gaactcggat aatgacacac cttttggtaa aggggcctta
    10501 tctgaaggct tttatcattc attagctcgc ttccgtccta ccataagccc aatcgatcct
    10561 aatggtcatt ttacggagct tacaatgatt ccctatttac aaagtggcac gtatacaaat
    10621 acacagaaaa ataatctgac actgactggt ggtctcgaag cacaaccaat caagaactgg
    10681 agaatattct tcgactatac gtaccggcaa aataatgaga attatgaggc gctcaacgta
    10741 gccccgatga tcccgggagc ggataacgag accttataca aagggacaag gcaagaatta
    10801 ggcgtgatgg agaatgggca attcacccgt tcatccgcct taagccaata tcaatcaatt
    10861 aatctatact caaactatat gttctctttg gccgataagc ataatttcac cgttatggct
    10921 ggttaccaag aagaaaatta cgcatatagc tatttatatg agtctgtaac cgacatgatc
    10981 tccaccaata atccaggcct caatcttggc acaggagaaa aatccacgac agatactcga
    11041 aacggatggg ctacccgagg atttttcgga cgtattaact atgattatga cggacgctat
    11101 ttattagaag tgaatggacg ctacgatggt tcttctcgtt ttgcctcaga tcatagatgg
    11161 ggatttttcc cttcggtctc tttaggatgg aatattacac gtgagtcttt catggaaaaa
    11221 tctttagagg tattatctaa tctaaagtta cgagcctctt ggggactatt agggaatcaa
    11281 agcggagccg gactttatac ttttacctca atcatgggaa tccagccgtt aggtaattgg
    11341 tattttcaag atggaagaga tatgtacata aacgcccctg gagttattga tccttttaca
    11401 acttgggaaa aagtggaaag taagaatctt ggccttgact tcgggttctt taacaacgct
    11461 ctcaccggca ccttcgatgt attccagcgg gatacaaaag atatgttagg accaagtgcc
    11521 gaccttgcag atttctttgg agcagaggct cccaatacga ataacgcaag gatgagaaac
    11581 cggggatggg aacttagcct gcaataccga ggaaaaatcg ggaaggatat tcattattca
    11641 ataggaggct ctttagctga cgcgacatcc gaagttacag cttatgaaaa tccgacaggg
    11701 accaatcctc aagataattg gtatgtaggg aagaaagtcg gtgagatttg gggatacaaa
    11761 gcctctgggc tactccagac ccaagaagaa gctgacacat ataataacac atacgattta
    11821 tctttcttat ccggtcaaaa atggatgccg ggagatgtta aatatatgga tttaaataac
    11881 gacaaaaaga tcaacaatgg aaataacaca ttggaagata tgggtgatat gtgtgttatc
    11941 gggaatacga ctcctcgata tcaatatacg cttaatggtt ccatttcatg gaaaggaatt
    12001 tcccttagca tgatgttcca aggcatagga aaacgtaatt ggtctccaga tctaggaacc
    12061 gtttactttt ggggatcggg agcttatgca caagtcacgg tattcaacga tcatctagat
    12121 tattggactc cagagaatcc agacgcctat tatcccaatc cttatacagg agcagcagga
    12181 agtatcaatc agtttcgaaa taagacctca caaaaaagtg acagatacat gcaaagtgcc
    12241 gcttattgcc gtttgaaaaa tctgacaatt agttatgatc tgcctaattc atggagccag
    12301 aaaattgggt tgagcaaagc acaagtgttt ttctctggag agaatcttct aacatttacc
    12361 aagcttcctt ccatgtttga cccggaagct atttttacag gaaatgacta taccagtgag
    12421 gccggaaaga attatccaat gaataaagtg ttatctatcg gagttattgt taatctataa
    12481 agcgtaattt atttatgaaa agaatatatc tatcaatggt ttccctatgt ctattagggc
    12541 taagtagctg tttcgacatg gataaatatc cggaaggaga attgtcttct gtcaattctt
    12601 tcaccagtac aacagaaatc accaagtatc tgaatcagtt ttatgaatca actcttaaaa
    12661 ttaatgacaa agatgtggca aactctgcca taaaggtaca atctaacagc attggaaatc
    12721 caacgggtat cgcctttgga gacttgaata gcgataatat gcagagtaat gtaatagaca
    12781 cacgtcttgc gggagaaacc acattaagtt ccgctgtcga attaacagag tataaacata
    12841 tcagaagtct aaacttctta atcaacaacc tcgataattg cgaggagatc ggtccggaaa
    12901 tggagcaatg catcggagaa gcttatttct tcagagcctg ctattattat aggttattcg
    12961 ttaattatgg agaagtcact tggttaacga aagtattaga tccgattcaa gaacagatgg
    13021 aacgtccccg aaacagtagg cttgaggtcg ctgatagtat attggcggat ttagatatag
    13081 cgatcgagca tctaaacact caaaccaata gctcgacaat gcgtgtacac aaagatgtag
    13141 caagagcgct taagagtgag gtcgctttat ttgaaggtac ttgggagaaa taccatcgtg
    13201 cgaaaaacac gccattctat gataaaaaag taactgatga gaaaatcagc tcttatctac
    13261 ggcaagccgc agatgccgct aaagatgtaa tagacgaagg ggtatggagc atctcaaaag
    13321 gggatcccaa taccgcttat cgagacttgt tcatcacttt ggatctctca cataatccag
    13381 aagttttatg gtggaagaaa tatgatgccg ccaataacat cggccattcc gtaacacgtt
    13441 atttaaataa aggaggtggc acttgtgggg catccgcttc tcttgttgat gattatttaa
    13501 caaaagaagg aaaacctttt gtcggttccg aacgagacaa agcaaaggta atgtacgggg
    13561 acgaattgag tccggactta cgagacccac gattatccca gaccatttgc atgccaggac
    13621 aagatttacg tccaaatgga gaattcgtat tcaaacttcc tcctttgaat gaggaaagcc
    13681 ggaatcaaaa tacgacaggt tattctatcc taaaatacgt agaatataat acgacttata
    13741 ttcctactat agatggggaa ggcaaaagcc aagcgccagc tatacaattc cgttacgccg
    13801 atattttatt aaactacgct gaggctctgg cagaattaga tggcgcggct aacgctagca
    13861 aaataaaaga agccttaagg ccacttcgag agcgtgtggg catgcccgag atggatttcg
    13921 acagagagtt caataccgat cccgattatc cgtttaataa attggataaa tatatacaag
    13981 cagtacgaag agaacgacgc atagaaaaag ctttagaggg aagccgactt caagatatct
    14041 tgcgctgggc cgccgcagac atcctcatta ttggaaaaac tccaacaggt gcattattca
    14101 aagggagctc tttggaaacc gcttatggag aaagcctgca agaaggtgaa aatcttttct
    14161 taacaggtac gccctccgac tccaaacgct atatcatacc gttcaataat aagcattatc
    14221 ctaacggatg gcaattcaat ccggaacgag attatttatt gcccatacaa cctcgtatgc
    14281 tatcgcttac aggtaaccaa tgggtccaaa accccggttg gtaatttact tgattacagg
    14341 atttagccta ataaaagaga aagtctttcc tcacaaattt taggctaaaa ccctgtaaca
    14401 aacaaattcc ttaatcacga acacaataaa agtctaaata atgaaaaaag aattattatt
    14461 cacattctct gctttaatag ctacgacttc ctgcaacatc aaaaaaacag attcagagca
    14521 gatagcagga aaaaagccga tgaatatcat ctatatcatg tctgacgatc attcttacca
    14581 gacaatcagt gcttatgata aacgcttcat acaaactccc aatatagacc gactggcaaa
    14641 cgagggagta cgtttcacca atagctttgt tgccaattcc atcagtggac ctagtcgagc
    14701 ctgtatatta accggtaaac atagtcatgc taatggtttc accgataaca gttccacatt
    14761 tgatggttcc cagcaaacat accccaaact tttacaaaaa gccggatatg aaacagcaat
    14821 aatcggaaag tggcatctaa cttccgctcc taccggattt gattattcgg aaattttaat
    14881 aggccaaggc atttattaca acgctccatt tatcaaaaac gggaaacagg tcccatcaaa
    14941 aggctatgtt accaacgtca tcacagaaaa agcaatcgac tggatggaga atatacatga
    15001 taaaaataag cctttctgct tgttactcca tcacaaagct cctcatcgta catggatgcc
    15061 cgatacttgt gatttacaac ttttcagcga tacgacattc gagttaccag ccaattttta
    15121 tgatgactac aacggtcgtc aagccgctca tgagcaaaag atgagtatca taaaagatat
    15181 ggatttagtc tatgatttaa aaatggctga taaagaaaat gaaatccata caactacagg
    15241 gttagagaat gccggacgca gcatgtataa cagtatgaca cccgaagaga aagcagcttg
    15301 ggatgctcat tatgatccaa tcattcagaa attcaagaaa gacaaacttt ctggtaagca
    15361 actatctgaa tggaaatatc aacaatatat gcgagactat ttacgtgtca tccattccat
    15421 agacagaaat attggagtat tattgaatta tttagaaaag acaggattat tagagaacac
    15481 aatgattgtc tacacttccg accaaggatt ctatatggga gaacacggat ggttcgataa
    15541 acgtttcatg tatgaggaat ctttccggac tcctttatta attcgtttgc cgggaggaaa
    15601 gaaaggagat atcgatgagt ttgtccaaaa cattgattac ggaccgacca tcctagattt
    15661 agcaggaatc caaatcccat ccgatatgca tggtatttcc tttttgcctt tgttacgtgg
    15721 agaaaaagtt gagaactggc gtaaatcact ctattaccac ttttatgagt accctgcgga
    15781 gcattctgtt aaacgtcatt atggcgtacg cacagaacgt tataaattaa ttcattttta
    15841 taacgatatc gataaatggg aattatttga tctacaagaa gatcctatgg agatgaacaa
    15901 cttgtatgga aaaacaggat atgagaatat cactcatcaa ctggaaaagg agcttatacg
    15961 tttacaaaaa caatatcaag acacgaatgc catgtcgttt aataaacaat taatccatga
    16021 a
//
