LOCUS       c00045_gnlPro..        13757 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LODLMCHJ_45.
ACCESSION   c00045_gnlPro..
VERSION     c00045_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 16:41:00
            Original ID  :: gnl|Prokka|LODLMCHJ_45
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 4929
            Orig. end    :: 18686
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13757
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[14929:18685]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13756
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..13757
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13757
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(113..634)
                     /locus_tag="ctg45_6"
                     /transl_table=11
                     /translation="MSTINYDLSRIKALAFDVDGVLSSTTVPLHPSGEPMRTVNIKDGY
                     AIQLAVKKGLHIAIITGGRTEAVRIRFAALGVKDLYMGSAVKIHDYRDFRDKYGLSDDE
                     ILYMGDDVPDIEVMRECGLPCCPKDAVPEVKSVAKYISYADGGRGCGRDVVEQVLKAHG
                     KWMAEDAFGW"
     CDS             complement(615..1409)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg45_7"
                     /sec_met_domain="F420_oxidored (E-value: 6.9e-14, bitscore:
                     42.7, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRSIEDTPVVFLGAGNLATNLAKALYRKGFRIMQVYSRTEESAR
                     TLANEVEAEYITDLKDVSNEARLYIISLKDAAFVELLPQITDGKQHALLVHTAGSIPMN
                     IWEGHVERYGVFYPMQTFSKQREVDFREVPFFIEAKRPEDTELLKAVAGTLSDKVYEAD
                     SEQRRSLHLAAVFTCNFTNHMYALAAELLEKYHLPFDVMLPLIDETARKVHELAPRDAQ
                     TGPAVRYDENVMNKHLSMLADSQALQEIYKLMSKSIHEHHQL"
     CDS             complement(1417..1752)
                     /locus_tag="ctg45_8"
                     /transl_table=11
                     /translation="MGAVKANNNKDTYKATAVAFIVIGTLFLINKLLPFASIGLPWVMN
                     KDNLLLYASISFLIFKRDKSVGFVLLGLWLVMNIGLVMSLLGSLSGYLLPLALLIIGII
                     LFWVSKR"
     CDS             complement(1755..2291)
                     /locus_tag="ctg45_9"
                     /transl_table=11
                     /translation="MENFSELIKNRRSMRKFTDEELTQDEVVALMKAALMSPSSKRSNS
                     WQFVVVDDKEKLKELSHCKEQASSFIADAALAIVVMADPLASDVWIEDASIASIMIQLQ
                     AEDLGLGSCWVQVRERFTATGMPSDEFVHGILDIPLQLQILSVIAIGHKGMERKPFNEE
                     HLQWEKIHINKFGGK"
     CDS             2391..2576
                     /locus_tag="ctg45_10"
                     /transl_table=11
                     /translation="MKKRITQDDYIKANRKASREAEIKEHGHPVCYKRVHESKKVYNRR
                     KIKAADKKLPYFFHLG"
     CDS             complement(2690..3232)
                     /locus_tag="ctg45_11"
                     /transl_table=11
                     /translation="MIEEMLAYNREFVKNEGYKEYITNKYPDKKIAILSCMDTRLTALL
                     PAALGIKNGDVKMIKNAGGVISHPFGSVIRSLLVAIFELGVEEIMVIAHSDCGACHMHS
                     EEMLEKMKARGINADYIHMMSFCGVDFHSWLDGFEDTEKSVRGTVDFIVHHPLIPSDVK
                     VHGFIIDSTTGELTRIV"
     CDS             complement(3419..5374)
                     /locus_tag="ctg45_12"
                     /transl_table=11
                     /translation="MKKIYSLVLLVAGVFSWGSCSLDEVNPNNSGQFSDGSYTLETYKA
                     FTNSCYTALINNIYQSSDYLVCTEAGTDIWEEPKSGSSYQRYHSYNGMKTDDSYYYKVW
                     QYSYLCINSCNIVIDGAENVTGDETEINECVAQARCLRAYYYMNLVEQFGNVDLQLKAA
                     DSENISFDAHRSTVPEIYAAIIEDLKFAVENLPVSFSDYYSRVTKKSAMGLLARAYING
                     AGYDLKDTDGVSFLEKAYDTATTMINNKAIYEWYMHPAFADVFNENNNRNNEEALFIAA
                     GAERNSDAYTNGNYSQSEMFRHFLPSLGTYTDLGLVDKTSNFVYGRPNSNIFLPSKYLM
                     DCFAADMNDSRFRYSFISAYSSYSIPAWGATYEYGGSACAKEITSTLATKFGIPASNIG
                     KKVYPHFNLESNSTADANYCQLAIWNADGTAKTTQDKTDGNILHPAMPLDPAEAHQYAV
                     YCSLKTLTEEEKAQYPGLVLNVFDLYDENGTARATYDKPSAASALWLSIYPALSKFNMP
                     GNKFVGRDVQRKTVDVMIMRMAEVYLIAAEASVRLNKGDAAKYINVLRTRAGAGTVSES
                     QVDLNYVFDEYARELCGECGRWYLLKRNAAFETRLAAYNKRAAEHFKKEFYLRPIPTKY
                     LDAINNPAEFGQNAGY"
     CDS             complement(5386..8580)
                     /locus_tag="ctg45_13"
                     /transl_table=11
                     /translation="MRENAFVEAWKTQHRRVSMILGLTLLCAPSAISVYAENGVNDITV
                     QAVMQTKTVKGTVLDENGEPLIGVSIVVKGTSTGTITDFDGKFSINLPAGSKELVVSYI
                     GYKEQAIIVSGNAPLNIKMVPDTQALDEVVVIGYGTVKKRDLTGAVASVKSEDITMNPG
                     VNPMDALQGKIAGLDITNSSGQAGSSPTVQLRGTRSLQLDEDGNISSDAFKPTYIIDGM
                     PGDIATLNPNDIESIEVLKDASSTAIYGSSGANGVIIVTTKGSKSGKPVINFNAYAGTT
                     LGAKVPKMRTGDSYINYIKDSYKPVGTTNEEEIFGERYDAIKNSQWVNWGDEVLHSGLK
                     QNYSISVAGGTEKTKAYFSLNYTDEKSMYENDDYKVYSTRVRIDQEINKWMNAGINVQA
                     SFSNKNSRNAVLERALFATPLGTPYNEDGSITEFPIPGSSSDPNPLADEQDGVYKNNTK
                     AGRAYVDAYLEWKPVKGLSVKSQLGGSYSQSRAGKFMGEGSYNVLKGSTVAYGEATNKT
                     GYNYKWENIVTYHNTFNKDHDLTVTGVTSWNYNQSEEYYVYGENPATNDMLWYALQNAD
                     NKKLNSKYLMSKGMGFIGRVNYSYKGKYLFSASSRYEADSRLSKDNRWNLFPAVSVGWR
                     ISDEAFMAGTKSWLDNLKLRVGYGVAGTTAGIAEYSSMASLENVTTSLGGMTVPSAKFT
                     EYITNRNLTWEKTHDLNIGIDASFLNNRIDLTVDLYRTKTTDVILSQALPTSIMGNYTG
                     STTYKMNKNAAETENRGIELALNTRNIVKKDFTWSSTVTFTANKEKIKSLIEGQDMMFN
                     AKKGDMVFKVGEGVGSFYRYKVLGIWQYSEKETAALFGCEPGDIKLDLPSVKKDGNGYY
                     YMNPEGERVDITAENPYGVRADYDRQVIGRNTPDWTLGFKNNFRYKDFDLSVFLYARWG
                     QMMNYGSVIGKYSPNPDYNIPTYFTYYDKTIEADQDVLFYAIDKSKDRSAYEGYDSMYY
                     VDGSFFKLKNVTLGYTLPGKLTKRFGISNLRVYATMTNLFTYSPNKYVKNYDPEMNGSI
                     NFPLSRDCIFGLNLTF"
     CDS             8829..9827
                     /locus_tag="ctg45_14"
                     /transl_table=11
                     /translation="MPLKLTTYYRGKDIPDLPGTNTFHSKELFQIYESTPGYTPLLIVA
                     TEEGRPVARLLAAIRKTKKWLPSSLVKQCVVYGAGEFLDTSLPASKEKEEEIFGEMLEH
                     LTQEASRTCILIEFRNLDNSMFGYRFFRKNDFFPVNWLRVRNSLHSTQKAEDRFSPSRI
                     RQIRKGLKNGAKVVEAHTVEEIKEFSRMLHKVYSSRIRRYFPANDFFRHMNSMLIRGKQ
                     AKIFIVKYKEKIIGGSVCIYSGENAFIWFSGGMRKTYALQSPGILAVWKALEDAHERGF
                     RHMEFMDVGLPFRKHGYRDFVLRFGGKQSSTRRWFRISWPWLNNLLVKFYV"
     CDS             10001..10405
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_15"
                     /sec_met_domain="Glyoxalase_4 (E-value: 2e-24, bitscore:
                     76.4, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGETKIELLEPTCPESTIAKFIENKGAGVHHVAFAVEDGVANALAEAESKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             10497..11885
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_16"
                     /sec_met_domain="CT_Btheta (E-value: 1.5e-273, bitscore:
                     897.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYLFAQDFTVTA
                     GSLSETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGV
                     IPQISGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGAS
                     VHSTKSGVTHFTAKTEEEGLALIRTLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIP
                     DSPNKPYDMYEVISAIVDNGEFLEIQKDYAKNIIIGFARFNGQSVGIVANQPKFLAGVL
                     DSNASRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVP
                     KVTITLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKDQENPA
                     QFLAEKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLSNPAKKHG
                     NIPL"
     CDS             11917..12837
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_17"
                     /sec_met_domain="OAD_gamma (E-value: 5.3e-15, bitscore:
                     46.2, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLLLLIGLTSCGEQKSNNKLLLNEVLIDNQNNFQD
                     DYGLHSAWIEIFNKSYGSADLAACLLKVSSQPGDTVTYFIPKGDILTLVKPRQHALFWA
                     DGEPNRGTFHTSFKLNPETANWVGLFDSGRKLLDQVVIPAGTLGPNQSYARISDGAADW
                     EVKGGSKDKYVTPSTNNKTLDSNAKMEKFEEHDSVGIGMSISAMSVVFCGLILLFIAFK
                     VVGKVAVNLSKRNAMKAKGIDKVEAKELSQAPGEVYAAISMALHEMQDEVHDVEETVLT
                     ITRVKRSYSPWSSKIYTLRENPNRK"
     CDS             12862..13296
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 66.7; E-value:
                     4e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_18"
                     /sec_met_domain="Biotin_lipoyl (E-value: 1.2e-21, bitscore:
                     66.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNSYKVTIGDIEDNIAHVEVNGTHYKVEMEKQPKTA
                     PKPVVVRPMPNSPAAPTTPVVKPAAPSTGKSGVKSPLPGVILDIKVNVGDTVKRGQTII
                     ILEAMKMENNINADKDGKVTAINVNKGDSVLEGNDLVIIE"
     CDS             13298..13756
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_19"
                     /sec_met_domain="OAD_beta (E-value: 6.3e-45, bitscore:
                     143.9, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFINFLGNNLADFWTYTGFANATVGHIVMILVGLFFIYLAVAK
                     EFEPMLLIPIGFGILIGNIPFNMDAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALEMGFDPMQAGAIGIIG"
ORIGIN
        1 ctcccaagcc tgacatcagt tctttccggc ggggagaatt ggaggctaat ataatctgat
       61 atttatctaa atttccaagc atagttttat ttatcattta gtgatttaca actcaccagc
      121 cgaaagcatc ttccgccatc cacttgccat gagctttcaa tacttgttcc accacatcac
      181 gtccacagcc acgaccgcca tcggcataag atatatactt cgcaaccgac ttaacttccg
      241 gaactgcatc tttgggacaa caaggcaacc cgcactcacg catcacttct atatcaggca
      301 catcatcgcc catatacaga atttcgtcat cagacagacc gtatttatcg cggaaatcac
      361 ggtaatcatg aattttcact gcagacccca tatacagatc cttcacaccc aatgctgcaa
      421 accggatacg taccgcttct gtccgtccac cggtaatgat agcaatatga agtcctttct
      481 ttaccgccag ctgaatggca taaccgtctt tgatattcac tgtacgcatc ggttctccgg
      541 aaggatgcaa cgggactgtt gtcgaactca atactccgtc aacatcaaaa gccagtgctt
      601 tgatgcggga tagatcataa ttgatggtgc tcatggatac ttttactcat taatttataa
      661 atttcctgca atgcctgact gtctgccagc atagaaagat gcttattcat cacattctcg
      721 tcatagcgta cagccggtcc ggtctgcgca tcacgaggag cgagttcatg cactttgcgt
      781 gccgtttcgt caatcagggg aagcatgaca tcaaatggca aatgatattt ttccagcaat
      841 tcggcggcaa gagcatacat atggttggta aagttacagg taaagacagc tgccagatga
      901 agacttctgc gttgctccga atcggcttcg tacaccttat cagagagtgt accggcaacc
      961 gctttcagca gctcggtatc ttccggtctt tttgcttcaa taaagaaagg tacttcccga
     1021 aaatcaactt cacgttgttt gctgaacgtc tgcatcggat aaaatactcc gtagcgttcc
     1081 acatgacctt cccaaatatt catcgggatg ctgcctgccg tatgcaccaa cagcgcatgc
     1141 tgcttcccat cagtgatctg aggcaacagt tcgacgaaag cggcatcttt caatgaaata
     1201 atatataatc tcgcttcatt cgatacgtct tttaaatcag tgatatattc cgcttccact
     1261 tcattggcta acgtacgagc cgattcttcc gttcggctgt acacctgcat gatacggaat
     1321 cctttccggt aaagcgcttt cgccagatta gttgccagat ttccggcacc gagaaacaca
     1381 acgggcgtat cttcaatact tcttttcatt gtttctttaa cgttttgaaa cccaaaataa
     1441 aataattccg atgatcaaca gtgccaatgg caacagataa ccggacaagg aaccgagcaa
     1501 tgacattacc agaccgatat tcattaccag ccacagtccc aacagcacaa agccgaccga
     1561 cttgtcacgc ttgaaaataa gaaaactgat agaggcatac aacaacaaat tgtccttatt
     1621 catcacccaa ggcaaaccta tagaagcaaa ggggagcagt ttatttatca ggaaaagagt
     1681 tccgatgaca ataaaagcga cggcagtagc cttataagta tctttattat tatttgcttt
     1741 gacagctccc atcgttattt tcctccgaac ttattaatat gaattttctc ccactgaagg
     1801 tgttcttcgt tgaaaggctt acgttccatt cccttatgtc cgatggcaat cacggaaaga
     1861 atctgcagtt gcaaaggaat atccaaaatt ccatgaacaa actcgtcaga cggcattccg
     1921 gttgcagtga aacgttcgcg aacctgtacc caacagcttc ccagccccaa atcttccgcc
     1981 tgcaactgta tcatgatgga agcaatagaa gcatcttcaa tccacacatc gcttgccaac
     2041 ggatcggcca tcacaacaat cgccaaagca gcgtctgcaa tgaaagaaga agcctgttct
     2101 ttgcagtgag acagttcttt caacttttct ttatcatcga ctaccacaaa ctgccagcta
     2161 ttactacgtt tggaactggg agacattaag gcagctttca tcagtgccac aacctcatcc
     2221 tgtgttaact cctcatccgt aaatttgcgc atactgcggc gattctttat cagttcactg
     2281 aaattttcca tattatttcc gttttcattt gatttatgta tgcaaagata gcgcaaaccg
     2341 atcgtaataa gaaatgaaat tgtatctttg cactgagaaa tatattcatt atgaaaaaac
     2401 gaattacaca agacgattac atcaaagcga atcgtaaagc cagccgtgag gcagaaatca
     2461 aagagcacgg acaccccgtt tgttacaaac gagtgcatga gtcaaagaaa gtatataacc
     2521 gtagaaagat aaaggcagcc gataaaaagc tgccttattt ttttcatttg ggatagtgtc
     2581 ggtatcccaa tgacatagtg acaccatgag acagtgatag tgacactatc ctgttgcgat
     2641 agtgacacca tgttttatgc agttcctgat aggcagaaag ggcgatttcc tatacaattc
     2701 gcgtcagttc tccagtagtg gagtctatga taaacccgtg cactttcacg tccgacggaa
     2761 tcaaaggatg atgaactata aaatcgaccg ttccccttac cgacttctcc gtatcttcaa
     2821 agccatctag ccaagaatga aaatcgactc cacaaaaact catcatatga atataatcgg
     2881 cattaatacc ccgtgccttc atcttctcaa gcatttcttc actgtgcata tggcaggctc
     2941 cacaatcaga atgggcaatc accattattt cctccacacc taactcgaag atagcgacaa
     3001 gcagactgcg aatcacacta ccgaaaggat gggaaatgac gcctcctgca ttcttgatca
     3061 ttttaacgtc tccgttctta atgcctagtg cggccgggag taaagctgtc aggcgtgtat
     3121 ccatacagga taagatagca atctttttat cgggatattt attcgttata tattctttat
     3181 atccctcgtt cttaacgaac tctctgttat aagcaagcat ttcttctatc atagcactat
     3241 tttgtttgga cacacaaaaa taaagaaaat aataaaaggc tgtatcagga aacaatgaaa
     3301 atataccgga aatccttttt aaacttttac gcaggataca ggtctggaaa caaagagccg
     3361 gacaagagaa atctcctgcc cggctcctat taattatgct tgattattaa ttaactgatt
     3421 aataaccggc gttttgtccg aattctgccg gattattgat cgcatccaga tatttcgtag
     3481 gaataggacg caaatagaat tctttcttaa agtgctcggc agcacgctta ttataagcag
     3541 ccaaacgagt ctcaaaagca gcattacgtt tcagcaaata ccagcggcca cattcgccac
     3601 aaagttcacg ggcatattca tcgaaaacat aattcagatc cacttgcgac tcactgaccg
     3661 taccggcacc ggcacgcgta cggagtacat taatatattt ggcagcatct cccttgttca
     3721 agcgtaccga tgcttcagca gcaatcaggt aaacttctgc catacgcatg atcatcacat
     3781 ccacagtttt tctctgaacg tctctgccga caaacttatt acccggcata ttgaatttag
     3841 aaagagccgg ataaatagat aaccacaaag cactggcagc actaggcttg tcataggtag
     3901 ccctggctgt tccattctca tcgtaaagat cgaaaacatt aagaaccaac cccggatatt
     3961 gagctttttc ctcttctgtc agcgtcttca aagaacaata aacggcatat tgatgagctt
     4021 ctgccggatc taaaggcata gcaggatgaa gaatattacc atctgtttta tcctgagtag
     4081 tcttcgctgt tccatctgca ttccagatag ccagctggca gtaattagca tcggctgtac
     4141 tattggattc caagttaaaa tgaggataaa ctttcttacc tatattagat gcgggaatac
     4201 caaatttagt agcaagtgtg cttgtgattt ctttggcaca cgctgaacct ccatattcat
     4261 aagtcgcccc ccatgccggt attgaataag acgagtaagc tgagataaat gaataacgaa
     4321 aacgagagtc gttcatatca gcagcaaaac agtccatcag atatttggat ggcaggaaga
     4381 tattactgtt cggacgaccg tatacgaagt ttgaagtctt gtcgaccaaa cccaggtccg
     4441 tatatgttcc caacgaaggt aagaagtgac ggaacatttc actttgtgag tagttaccat
     4501 tggtgtaagc gtccgaattt ctttcggcac ccgcagctat gaacagagct tcttcattgt
     4561 tacgattatt attttcgttg aatacatcgg caaaagcggg atgcatatac cactcataaa
     4621 tcgctttatt attaatcatg gttgtcgccg tatcataggc tttttccagg aagctgacac
     4681 catcggtatc tttcagatca taaccggcac cattaatata tgcacgtgcc aataatccca
     4741 tcgccgattt ctttgtaacg cggctatagt aatcactgaa acttacaggc agattctcta
     4801 cggcaaactt caggtcttcg ataatggcag cataaatttc gggaacggta gaacggtgag
     4861 catcaaaaga aatattctcg ctatcggcag ccttcaactg caaatcgaca tttccaaact
     4921 gctccaccag attcatataa tagtaagcac gcagacatct ggcctgtgcc acacattcat
     4981 taatttcagt ctcatcccct gtcacattct cagctccgtc aatcacaata ttacagctgt
     5041 tgatacacag ataagaatat tgccacactt tataataata gctatcatcg gttttcatac
     5101 cgttataact atgataacgc tgatagctgg aacccgattt aggttcttcc caaatatcag
     5161 tacccgcttc cgtacaaacc agatagtcac tactctgata gatgttgttg atcaaagctg
     5221 tatagcacga gttggtgaat gccttataag tttccaatgt ataagaacca tcggagaact
     5281 gacccgagtt gttggggttc acttcatcaa gactgcaaga gccccaagaa aaaacaccgg
     5341 caacaagtag aactaaacta tatatctttt tcatattgct attttttaga aagttaaatt
     5401 aagaccaaat atgcaatcac gagacaatgg gaagttgatg cttccgttca tttccggatc
     5461 gtaattcttc acatatttgt ttggcgaata agtaaacagg ttggtcattg tcgcataaac
     5521 tctcagatta ctgataccaa aacgttttgt aagtttaccg ggtaacgtat aacccaatgt
     5581 tacgttttta agtttaaaga atgatccatc cacataatac atcgaatcat atccttcata
     5641 agcacttcta tccttggatt tatcgatagc atagaacaag acatcctgat ctgcttcgat
     5701 cgtcttgtca tagtaagtaa aataagtagg aatattgtaa tccgggttag gcgaatattt
     5761 acctatcaca ctaccatagt tcatcatttg cccccaacgt gcataaagga agacagacaa
     5821 atcaaaatct ttgtatctga aattattctt aaagcccaat gtccagtccg gagtattacg
     5881 acctattacc tgacgatcat aatccgcacg tacaccataa ggattttctg ccgtaatatc
     5941 aacgcgctct ccttcaggat tcatataata ataaccattt ccgtccttct tcacactagg
     6001 taaatccagc ttaatatcgc ccggttcgca tccgaacaaa gcagcagttt ccttttcgct
     6061 atattgccag atacccaaca ctttatatct atagaaagaa ccgactcctt cgccgacttt
     6121 gaacaccata tcaccctttt ttgcattgaa catcatatcc tgcccttcga tcaaagattt
     6181 aattttttct ttgttggcgg taaatgtcac tgttgagctc caagtaaaat ctttcttcac
     6241 aatattacgg gtattaagag caagttcaat accgcgattt tctgtttcag cagcattctt
     6301 gttcatttta taagtagtgc tacctgtgta attacccata atagatgtcg gcaatgcctg
     6361 cgaaagaatt acatccgttg tttttgtccg atacaaatcc accgtcagat caatacgatt
     6421 attgaggaag ctggcatcaa taccaatatt caagtcatga gtcttttccc atgtcagatt
     6481 acggttagtg atatactccg taaacttggc tgacggaaca gtcattcctc ccaaagaagt
     6541 tgtcacattt tccaaagatg ccatagaact gtattcagca ataccggcag tagttccggc
     6601 aacaccatag cctacacgca gtttcaagtt atccaaccag ctttttgtac cagccataaa
     6661 tgcttcatcc gagattctcc agcctacaga aactgccggg aataaattcc atctattgtc
     6721 tttcgacaaa cgggaatccg cttcataacg actggaagca gagaacaggt atttaccttt
     6781 gtatgagtag ttgacacgac cgataaagcc catccccttc gacatcagat atttgctgtt
     6841 cagtttctta ttatcagcat tctgcaatgc ataccacaac atatcattgg tcgccgggtt
     6901 ttcaccatag acataatatt cttcactctg attgtaattc caggaagtaa cccctgtaac
     6961 cgtcaggtca tgatccttat taaatgtatt gtgataagtt actatgtttt cccatttgta
     7021 attatatccc gtcttattgg tagcttcgcc atatgccacc gtactgcctt tcaacacatt
     7081 ataagagcct tctcccataa atttaccggc acgagattga gaataactgc ctccaagctg
     7141 tgacttgaca gacaatcctt ttaccggttt ccattccaga taagcgtcaa cataagccct
     7201 tcctgcttta gtattattct tatatactcc atcctgttcg tctgctaacg gattcgggtc
     7261 tgatgatgaa cctggaatcg ggaattccgt gatagagccg tcttcattat aaggagtacc
     7321 taacggggtg gcaaacaatg ctctttccaa aacggcatta cgtgaattct tgttggagaa
     7381 agatgcctga acattaatac cggcattcat ccatttattg atttcctgat ctatacggac
     7441 acgggtagag tacactttat agtcatcatt ctcatacata ctcttctcat cagtatagtt
     7501 caacgagaaa taggctttcg tcttctcagt acctccggca acggaaatac tataattctg
     7561 cttcaaacct gagtgtaata cttcatctcc ccagtttacc cattggctgt ttttgatggc
     7621 atcgtatctt tcaccgaaaa tttcctcctc attagtagta ccgacaggct tataagaatc
     7681 ttttatataa ttaatgtatg agtcacccgt acgcatctta ggaactttag ctcctaaagt
     7741 cgttccggca taagcattga aattgatgac cggttttcca ctcttggatc ctttcgtagt
     7801 cacgataata acaccattcg caccacttga accgtagata gccgtagaag atgcatcttt
     7861 cagtacttcg atagattcaa tatcattggg attcaaggta gcaatatcac ccggcatacc
     7921 atcgataata taagtcggct taaatgcatc ggaagaaata ttaccatcct catccaactg
     7981 caaagagcgg gtaccacgca actgaactgt cggtgacgaa cctgcctgac ctgaagaatt
     8041 agtgatatcc agacctgcaa ttttaccttg cagcgcatcc atcggattca cgcccggatt
     8101 catggtgata tcctctgatt tcacagaagc aaccgcacct gtcaaatcac gtttctttac
     8161 cgtaccgtaa ccgatgacca ctacctcatc caaagcctgt gtatccggaa ccatctttat
     8221 attcagcggg gcatttccgc tcacaataat agcctgttct ttatatccga tataagaaac
     8281 aaccagttct ttacttccgg ccggaagatt aatggagaac ttaccgtcaa aatcagttat
     8341 cgtacctgta cttgtacctt tcaccacaat agagacaccg atcaacggtt ctccattttc
     8401 atctaaaaca gttcctttca ctgtctttgt ctgcatgacg gcttgcacag taatatcatt
     8461 cacaccattt tctgcataaa cagatatggc agaaggggca cacaataaag tcagccctaa
     8521 aatcatggaa acgcgtctat gctgtgtctt ccacgcttca acaaatgcat tctctctcat
     8581 tcgttttaat ttaaagttaa tattaatttt cctttgttta gtaaaataca attagcataa
     8641 tcttttacat agacgtttcc attttacttc tgtactcaca aaggacgaca ataatacaaa
     8701 aattcgcttt tccaagcctt tttttcctca aatatatgca aaggataaaa agacaaattt
     8761 taggctaagc caacaaattc tcttttttat tgttgaatga agaataaaaa gtgtaaattt
     8821 gtatttggat gccacttaaa ctaacaacat attatcgcgg aaaagacatt cctgatttac
     8881 cgggaaccaa tacttttcat tccaaggagt tgtttcagat ctatgaatcg actccgggat
     8941 ataccccgct actgatagtg gcaacagaag aaggcagacc tgtagcacgc ctgcttgccg
     9001 ccatacgcaa gaccaaaaag tggcttccct cctctcttgt caaacaatgt gtggtatatg
     9061 gtgcaggtga atttctggac acttctctac cggcaagtaa agagaaggag gaagaaattt
     9121 tcggtgaaat gctggagcat ctcacacaag aagcatcacg cacctgcatt cttattgaat
     9181 tccgcaatct ggataattcc atgttcggtt accgtttctt ccgaaagaac gacttttttc
     9241 cggtcaactg gctgcgtgtc cgtaactctc tgcatagtac gcagaaagcg gaagaccgtt
     9301 tcagcccgtc acgtatccgt cagatccgga aaggactcaa aaacggagcc aaagtagtag
     9361 aagcccatac ggtggaagag attaaggaat tctcgcggat gctgcacaaa gtttattctt
     9421 cacgaatacg gagatatttc cctgccaatg actttttccg ccacatgaac agcatgctta
     9481 tcagaggaaa acaggcaaaa atattcatcg taaaatacaa ggaaaagatt atcggcggct
     9541 ccgtctgcat ctattccggc gaaaatgctt ttatctggtt ttcaggagga atgcgaaaga
     9601 cgtatgcact gcagtcaccc ggcatactgg cagtatggaa agcacttgaa gatgcccatg
     9661 aacggggatt ccgtcacatg gagttcatgg atgtaggact tcccttccgc aaacatggtt
     9721 atcgtgattt cgtactccgt ttcggaggca aacaaagcag tacccgccgc tggttccgta
     9781 tcagctggcc atggctgaat aatcttctgg tcaagtttta tgtctaaatg taatctcaag
     9841 attacaaaac ccgtctttgt cacccatccg gagcattttt tatgctttat tccccaataa
     9901 ttaaatgcag aaatatttct ttattagaca agaaatgtct ttctttgtgc tgttttatgc
     9961 catataagca cataattaaa ccatataaaa aaatatagtt atgaagattt cacacattga
    10021 gcatctgggc attgctgtaa aaagcatcga agaagccctt ccttactacg aaaacgtatt
    10081 gggtctgaaa tgttacaaca tcgaaacagt agaagatcaa aaagtaagaa ccgctttttt
    10141 aaaggtaggt gaaacaaaaa tcgaattgtt ggagccgact tgccccgaaa gcaccattgc
    10201 taaatttatt gaaaacaaag gtgcaggtgt tcatcacgta gcatttgccg tagaagatgg
    10261 cgtagctaat gctttggcag aagcagaaag caaagaaatc cgtctgattg acaaggctcc
    10321 ccgcaaaggt gccgaaggtc tgaacatcgc tttccttcac ccgaaatcaa cactgggtgt
    10381 gctgacagaa ctctgcgaac actaatcata aactctaaaa aacaacaaga actcatgagt
    10441 aatcaacttg aaaaaattaa agagcttatt gaacgcnnnn nnnnnnagaa atggacatgt
    10501 tcgttgagca cagatgcacg aacttcggca tggagaaaaa gcactatccg ggtgatggtg
    10561 tagtaaccgg ttgcggtact atcgaaggtc gtctcgtata tctttttgca caggacttta
    10621 ccgttactgc aggttcactg tcggaaacaa tgtcactgaa gatctgtaag attatggatc
    10681 aggcaatgaa gatgggtgct ccttgtatcg gtatcaatga ctcgggtggt gcacgtatcc
    10741 aagaaggtat taacgctttg gcaggttacg cagaaatctt ccagcgcaat atcctcgctt
    10801 cgggtgtcat tccgcagatt tccggtatct tcgggccttg tgccggcggt gctgtttatt
    10861 ctccggcact gacagacttc acactgatga tggaaggtac ttcttatatg ttccttacag
    10921 gtccgaaagt agtgaaaact gtaaccggtg aagacgtaag ccaggaaaac ctcggcggag
    10981 caagcgttca ctctaccaaa tcgggtgtta ctcatttcac tgccaaaaca gaagaagaag
    11041 gtctggcatt gatccgcaca cttctgagct atattcctca aaacaacctc gaagaagctc
    11101 catacgtgga ttgcacagat ccgatcgacc gtctggaaga ttctctgaac gatattatcc
    11161 ccgacagccc caacaaaccg tatgatatgt acgaggttat cagcgctatc gtggacaacg
    11221 gcgaattcct ggaaatccag aaagactatg ccaagaatat cattatcggt tttgcccgtt
    11281 tcaacggtca gtctgtaggt attgtagcca atcagcctaa attccttgcc ggtgtactcg
    11341 acagcaacgc atctcgcaaa ggcgcacgtt tcgttcgttt ctgcgatgct ttcaatatcc
    11401 ctatcgtgtc gttggtagac gtaccgggat tccttccggg aacaggccag gaatacaatg
    11461 gcgttatcct tcatggtgcc aaactgctgt atgcttacgg tgaagctacc gtacctaaag
    11521 taacaatcac attgcgtaaa tcttacggtg gttctcacat cgtgatgagc tgtaagcaac
    11581 ttcgcggtga tatgaactat gcttggccta cagctgaaat cgctgtaatg ggtggtgccg
    11641 gcgcagtaga agtattgtac gcgcgtgaag ccaaagacca ggaaaatccg gctcagttcc
    11701 ttgccgaaaa agaagcagaa tatacaaaac tgtttgccaa tccttataat gcagctaagt
    11761 atggttacat cgatgatgtc atcgaacccc gtaacacacg tttccgcgtg atccgtgctt
    11821 tgcagcagtt gcagactaag aaactgtcta acccggcgaa gaaacatggt aatattccgt
    11881 tgtaatccaa cttttcacat taaaacaaga acgattatga acaaaaccaa aatcggaata
    11941 ttcctttctc tgctgttgct gattggattg acttcctgcg gagagcaaaa gtcgaacaat
    12001 aagctattgc tgaatgaagt cttgatagac aatcaaaaca actttcagga tgactacggc
    12061 ttgcacagtg catggattga aatattcaac aaatcatacg gtagcgcaga cttagcagct
    12121 tgtttattga aagtaagcag ccagccgggc gatacagtaa cctattttat cccgaaaggt
    12181 gacatactta cattagtaaa gccacgccaa catgcgttat tttgggcaga cggcgaacct
    12241 aatcgtggta ccttccatac cagcttcaaa ctgaaccctg aaacagccaa ttgggtcggt
    12301 ctttttgatt caggcagaaa gctacttgat caagttgtca taccagcagg aactttaggt
    12361 cccaaccagt cttatgcacg cataagcgac ggagcagcag actgggaagt aaaaggcgga
    12421 agcaaagaca aatacgtaac cccgagcacg aacaacaaaa cccttgacag taatgccaag
    12481 atggaaaagt tcgaagaaca tgactcagtc ggtatcggta tgtctatttc agccatgagc
    12541 gtagtattct gcggattgat tcttctcttc attgccttca aggtggtagg taaagttgct
    12601 gtcaacctga gcaaacgcaa tgcgatgaag gctaaaggca tcgataaagt cgaagcgaaa
    12661 gagctttcac aggctccggg tgaagtttat gctgctattt caatggcatt acacgaaatg
    12721 caggatgagg tacatgacgt agaagaaacg gtgctgacca tcactcgtgt gaaacgcagt
    12781 tattcaccgt ggagttcgaa gatttacacc ttgcgtgaaa atcctaacag aaagtaaatc
    12841 attccctaaa aagataaaac gatgaaagaa tataaatata aaatcaacgg taactcatac
    12901 aaagtaacca tcggagatat tgaagataat atcgctcatg tagaagtgaa cggtacgcac
    12961 tacaaagtag aaatggagaa acaaccgaaa actgctccca aaccggtagt agtacgtcct
    13021 atgcctaact caccggctgc tcctaccaca ccggtagtaa aaccggctgc tccttctaca
    13081 ggcaaatcag gcgttaagtc cccgctacca ggcgttatcc ttgacatcaa agtaaatgta
    13141 ggtgatacag tgaaaagagg acagactatc attatattgg aagccatgaa gatggaaaac
    13201 aatatcaatg cagacaaaga cggtaaagtg actgctatca atgtcaacaa gggagattct
    13261 gttcttgaag gtaatgacct cgtaattatt gaataatatg ggagatttta ttaacttttt
    13321 aggaaataac cttgccgact tctggaccta cacgggattt gccaacgcga cagttggtca
    13381 tatcgtgatg atcctcgttg gcttgttctt catctatttg gctgtagcca aagagttcga
    13441 gccgatgttg ttaattccta tcggattcgg tatcctgatc ggtaatatac ccttcaatat
    13501 ggacgccgga ctaaaagtcg gtatatatga agaaggttct gtattgaaca tattgtatca
    13561 gggagtaacg tccggctggt atccaccgct catcttctta ggtatcggtg ccatgacaga
    13621 cttctcggcg ctgatctcca atccgaagct gatgctgatt ggtgcagctg cccagtttgg
    13681 tatcttcggt gcatacatga tcgcattgga aatgggattt gacccgatgc aggccggtgc
    13741 tatcggtatc atcggtg
//
