LOCUS       gnlProkkaFAEELCLN_41   12848 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FAEELCLN_41.
ACCESSION   gnlProkkaFAEELCLN_41
VERSION     gnlProkkaFAEELCLN_41
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 16:54:07
            Original ID  :: gnl|Prokka|FAEELCLN_41
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12848
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12848
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[3534:7848]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3535..7848
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..12848
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12848
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             3..2312
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 32.1;
                     E-value: 7.9e-10)"
                     /gene_kind="transport"
                     /locus_tag="ctg41_1"
                     /sec_met_domain="Poly_export (E-value: 1.5e-18, bitscore:
                     57.0, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDGIRQGKEQKQLASELARKGVTKEQAMRVKQLYEQQNNVNTSK
                     STGTDINESRLREETKKNTSDMLEDHPTTQDLARGDQVFGRNIFNTRNLTFEPSVNLAT
                     PANYRLGPGDEVIIDIWGASQNTIRQQISPEGTINIQKIGPVNLSGMTVSAANDYLKNA
                     LNKIYNGLNNTTDPTSDIRLTLGNIRTIQINVMGEVVQPGTYALSSFSTVFHALYRAGG
                     VSDIGSLRNVQLVRNGKNIATIDVYEFIMKGNTQDDIRLQEGDVVIVPAYDVLVKISGK
                     VKRPMRFEMKKDENLATLIKYAGGFEADAYTRSLRVVRQNGEEYEVNTVKDMDYSIYTM
                     RNGDVVTAEAILNRFTNKLEIRGAVYRPGIYQLSGKLNTIRELVHEAQGLTGDAFLNRA
                     VLYRQREDLTSEVVQIDIKSIMDGTSPNLALMKNDILYIPSIHDLEDRGNVTVHGEVAH
                     PDSYPYADNMTLEDLIIQAGGLKEAASTVRIDVSRRIKNPRSTADNDTIGQMYTFSLKD
                     GFVIDGQPGFILEPYDQVYVRRSPGYQAQQNVAIEGEILFGGNYAMTSREERLSDLVNK
                     AGGPTNYAYLRGAKLTRVANASEKKRMGDVIRLMSRQLGEAMIDSLGIRVEDTFTVGID
                     LEKALSNPKSNADLVLREGDVISIPKNTNTVTINGAVMVPNTVSYMKGKNVDYYLNQAG
                     GYSDNARKSKKFIVYMNGQVTKVKGSGKKQIEPGCEIIVPGKAKKKGNIANILGYATSF
                     SSLGMMIASIANLIKK"
     CDS             2323..3471
                     /locus_tag="ctg41_2"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             3535..4254
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 54.5; E-value:
                     1.6e-16)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 2.4e-16, bitscore:
                     50.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             4275..5576
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_4"
                     /sec_met_domain="CTP_transf_like (E-value: 2.9e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 3e-121, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 3.4e-63, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             5593..6717
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.6e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.4e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             6727..7848
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg41_6_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_6"
                     /sec_met_domain="Aminotran_5 (E-value: 2.3e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        6817..7824
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg41_6_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg41_6_Aminotran_5.1"
                     /locus_tag="ctg41_6"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             7845..7988
                     /locus_tag="ctg41_7"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             8191..9675
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg41_8"
                     /sec_met_domain="Polysacc_synt (E-value: 2e-31, bitscore:
                     99.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLS
                     FLFKLDSFFCILTLIIKTKNIDENIKKDFSSNSKDN"
     CDS             9629..10888
                     /locus_tag="ctg41_9"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             10897..11646
                     /locus_tag="ctg41_10"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKNSK"
     CDS             11646..12686
                     /locus_tag="ctg41_11"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 atgtaaagga cggtatccgg caaggcaagg aacagaagca gcttgcttcc gaactagccc
       61 gtaagggtgt aaccaaagaa caggcaatgc gtgtgaagca gctatacgag cagcagaaca
      121 atgtaaatac ctcgaaatca acgggcacgg acatcaacga atcccgcctg cgtgaagaga
      181 ctaagaagaa tacttccgat atgctggagg atcatccgac tactcaggac cttgcccgtg
      241 gtgatcaggt cttcggacgt aacatcttca atacccgcaa cctgacgttc gagcctagtg
      301 tcaaccttgc cactcctgcc aattaccgtc ttggtcccgg tgatgaagtc atcattgata
      361 tctggggtgc gagccagaac acgatccgcc agcaaatctc tcctgaaggt actatcaaca
      421 ttcagaagat cgggcctgtc aaccttagcg gtatgacagt ctctgccgcc aatgactatc
      481 tgaagaacgc cctgaataaa atatataacg gtctgaataa tactaccgat cctacttccg
      541 acatccgtct gacgttaggt aatatccgta ctattcagat taatgtgatg ggagaagtcg
      601 tacagcccgg tacctacgcc ctttcttcct tctctaccgt cttccatgcg ctttatcgtg
      661 caggcggtgt gagtgatatc ggtagcctcc gaaacgttca gttggtacgc aacggaaaga
      721 atattgccac catcgacgtc tacgaattca ttatgaaagg caacacacag gatgacatcc
      781 gcctacagga aggtgacgtt gtgattgttc ctgcctatga tgtattggta aagattagcg
      841 gcaaggtaaa acgtcctatg cgttttgaaa tgaagaaaga cgagaacctt gctactctca
      901 ttaaatatgc cggcggcttt gaagctgatg cctacacccg ttcattacgt gttgtccgtc
      961 agaatggtga ggaatacgaa gtcaacacag tcaaggatat ggactacagt atctacacaa
     1021 tgcgtaacgg tgacgttgta acagccgaag ccatccttaa ccgcttcaca aacaaactgg
     1081 aaatccgtgg cgctgtctat cgtcccggta tctaccagct cagcggtaaa ctgaacacga
     1141 tccgcgaact tgtccatgaa gctcagggtc tgaccggtga cgctttcctg aatcgtgccg
     1201 tcctctatcg ccagcgtgaa gacctgacca gtgaagttgt tcagatagac attaagtcta
     1261 tcatggacgg cacttcccca aaccttgccc taatgaagaa tgacatcctc tacattccaa
     1321 gtatccatga cctggaagac cggggtaatg tcacagttca cggtgaggtt gcccaccctg
     1381 attcctatcc ttatgcggat aacatgacac ttgaggatct gatcattcag gccggtggct
     1441 tgaaagaagc cgcctccact gtccgcattg atgtgtcgag acgaatcaag aatccccgta
     1501 gtaccgcgga taatgatact atcggtcaga tgtatacctt ctctttaaag gatggttttg
     1561 taatagatgg tcagcccggt tttatccttg agccttatga tcaggtttat gtccgtcgca
     1621 gtccgggcta tcaggcacaa cagaatgtag ccattgaagg tgaaatcctt ttcggaggaa
     1681 attacgccat gaccagccgt gaggaacgtc tttccgattt agtgaataaa gccggcggtc
     1741 cgaccaatta tgcctatctg cgtggtgcga aactgacccg tgtggctaac gctagtgaaa
     1801 agaaacgtat gggtgatgta attcgcctta tgagcaggca attgggcgaa gccatgattg
     1861 actctttggg tattcgtgtt gaagatactt ttacggttgg aatagatttg gaaaaagcct
     1921 tgagcaatcc taaaagtaat gccgatcttg tcttacgtga aggtgatgtg atctccatac
     1981 ctaagaatac taatactgta actatcaatg gtgctgtcat ggttccgaat acggtttctt
     2041 atatgaaggg caagaatgtg gattattacc tgaatcaggc cggtggttat tctgataatg
     2101 caaggaagag taagaaattc attgtttaca tgaatggtca ggtgacgaag gttaagggta
     2161 gtggtaagaa acagattgag ccgggatgtg agattattgt gcctggtaag gctaagaaga
     2221 aagggaacat agctaatatt ttaggttatg ctacttcctt cagttctttg ggaatgatga
     2281 ttgcttctat tgctaatttg ataaagaaat aaatgaccta ttatgattga aaagcaatct
     2341 tatcaagaac cgttttctga agtggataaa aggaaagatg atgaaatgga aatagacttg
     2401 atggctattt tttataagat tattactgtt cgtggagtac tatgcaaagc tgctggagtg
     2461 ggagtaataa ttgctatagt ggtggcattg agcattccca agcaatatac agtaaaggtt
     2521 accctttctc ctgaaatggg taatgcgaag ggaagtaatg gtttagccgg acttgctgcc
     2581 tcgtttttgg gagatggggc tctaataggg gaaagcacag atgccttgaa cgcttctctt
     2641 tcagcagata ttgtttcttc aactcctttt ttattggaac ttttagaaat ggaagtctcc
     2701 gtttctaaaa aggatgataa aatgactttg gggtcttatc tcgatgaaga gtcatctcct
     2761 tggtgggatt atcttatagg ttttccgggc atagtaatag gaggagttaa atcattattc
     2821 ggagaagata cggttcctgc cagtggaggg cggcaaggaa ctatcgaatt gacgaaagaa
     2881 gtaaatgaga agattaattt tcttaaaaag aagattagtg catccattga taagaaaacc
     2941 gccataacga gcattacggt caccttacaa aatccgcaga tcactgcggt tatagcagat
     3001 tctgtcgttc ataaattaca ggaatatatt attgggtatc gaacttcaaa agtaaaagaa
     3061 gactgtgcgt atttggaacg gttgtttaaa gaacgtcagc aggaatatta tgctgctcaa
     3121 agaaaatatg cggattatgt agacgcccat gataatgtgg ttcttcaaag tgtacgtgct
     3181 gagcaggagc gtttacagaa cgacatgagt ttggcttatc agatatatag tcaggttgct
     3241 aatcagttgc aggtatccag agccaaagta caggaggaaa agccagtctt tgcagtagtt
     3301 gagcctgccg ttgtaccttt gaaaccttca ggtatgggac tcaaaattta tattttatta
     3361 tttgtgttcc tgtccgtatc tggtactctc gtgtgggtgt tttttggcaa aagtctgctg
     3421 gctagcttga gaaaagaact gaaaaataag gagatagaac aggataaatg atgctaaaac
     3481 gtcgtttaca acattcttac atcaattaaa ttcacttact atattattaa acgaatgata
     3541 cgtacagcta tgataatggc tgcgggcatg ggaacccgtt ttggccaata tacagaattg
     3601 atacctaaag ggttcgtcaa agtgggaggt attccaatga tagttcgttc tattgatact
     3661 ttgttatcat gtgacattga gcgaattgta atcggtacag gatataaaca agaagtttat
     3721 gaagaattga agacagacta tcctatgctt gaaacctgtt ttagtcctcg ttatgctgaa
     3781 acaaatagta tgtatacttt atataatacg cgggagattc tgggcaatga tgatttttta
     3841 ttgttagagt cagatttgat ttttgagaaa caagcaataa tgagcttatt ggagtgtcct
     3901 gcggcagatg caatgctaat aactccagtg acaaagtttc aagatcagta ttatgtggaa
     3961 catgatgata attttcgcct ttcttcatgt tctgtcaata agaataaact aaacgctaaa
     4021 ggcgaattgg tcggcatcca taaactatcc ggttcctttt acaaaataat gtgtgctgat
     4081 tatgcgagta ttgttgatga acaacccaat ttgggatatg agtatgaatt actacgaata
     4141 tcttgttctc aatctcctgt ttatgtgcat aaagtagaag ggctgaaatg gtatgaaatc
     4201 gatgacatat cagatttgga atatgcagag aaatatattg ttccgtattg ttaattaaaa
     4261 taatatatca aattatgagt aagacagttt atattgggat gactgcggat attatgcatc
     4321 caggacttat ccgcattatt aatgaggcta ctaaatacgg tgatgttata attggtcttc
     4381 ttacagataa agctattgcg gagcataaac gccttcctta tctgacctat gaacaacgaa
     4441 aagaggtagt tcagaatatt aaaggcgtat gtaaagttgt tcctcaagaa gaatggagct
     4501 atgttgagaa tctcaaacgc attaaacctg actatataat tcatggtgac gactggaaaa
     4561 ccgggccttt acgtgaagaa cgtgtgcgcg tatttgaagt gatgaatgaa cagggaggaa
     4621 aggttatcga aattccatat actttgggaa ttaattcatc ttctttggat aaagatatta
     4681 aggctatagg tacaacccct gatgtacgtt taaaatcact tcgtcgtttg ataaatgcca
     4741 aacccgtagt tcgtattttg gaagctcatg atggactatg tggcttgata attgaaaatc
     4801 aggaaatatt aaaaggggat aagagggaag tatttgacgg aatgtggtct agtagcctta
     4861 cggattcaac cagtaaaggt aaacctgata ttgaggcggt tgatttaact acccgattgc
     4921 aagatttgaa taatattctg gagtgtacta ctaaacctat tatttttgat ggagatacag
     4981 gtggtaaaat tgaacatttc gtatttacag tacgcacttt agaacgtcat ggaatttcag
     5041 ctataataat tgaagataaa gttggattaa aaaagaattc attgtttggt acagatgtta
     5101 ttcaaactca agatacaatc gaaggtttct gtaataagat caaagcagga aaggcatctc
     5161 agattactga tgattttatg attatcgctc gtattgagag ccttatagcg ggaaagccgg
     5221 taagtgatgc tttagagaga gcttttgcat atgtccaagc gggagcggac ggtattatga
     5281 tacatagcaa aaataagtcg ggtgaagata taaaagaatt ttgtttggcg tttcgaaaac
     5341 agtatgctca tgtacctatc gtggttgtgc ctactacata tgatcatatt tatgagtctg
     5401 aattgtgtga ttggggtgtg aatataatta tttatgctaa tcatatgctt cgtgccgctt
     5461 atcctgctat gatgaatgtc gcaaagataa tattagagaa tgaacgtgct ttagaggtgc
     5521 gcgaactgtg tatgcccata aaagaaatat tggaactgat tccaggtact aaataaaaag
     5581 aggaatatca ttatgttaag cgtagaaaaa gtttatgaaa cgtttctgag tcatgacgtt
     5641 gattttttta caggagttcc agactcatta ctaaaaaata tttgtgccta tatcacagac
     5701 catacttcac gtgagaaaca tatcatagct gctaatgaag gtgcggctgt aggaattgct
     5761 tcaggttatt atatggcatc aggtaaggtt cctgtggttt atatgcaaaa ttccggcttg
     5821 ggtaatactg ttaatcctct gctgtctctt gcagatgaac aagtatacag ttttccaatg
     5881 cttttgatga ttggctggcg tggtgaaccg ggaacaaaag atgaacctca gcataaaaaa
     5941 cagggtgagg taactttaga tttgttgaaa gcaatgcgga ttccttatat aattcttgat
     6001 tcaaatgaga atgatgcatt tattcagctc catgatatca tacaatcagc aaaaactaag
     6061 aatattcctc atgcaataat tattcggaaa gatgtttttg gcaaatataa acttcaaaaa
     6121 gagttcggat gtaattatcc tttatctcgt gaggatgctt tgcaaatagt tgtggattat
     6181 ctgcctgaaa attcagtggt cgtttctact actggcaagc tttctcgtga gttatttgaa
     6241 tatcgagaaa tgaaagagca aggtcatgaa catgattttc tcacggtagg ctctatggga
     6301 catagttcat caatctcttt gggtattgct atagcaaagc aagatagacc tgtttattgc
     6361 ttggatggtg atggagcatt tattatgcat ttaggggcaa ttagtaacat tggcgattta
     6421 tctcctaaaa actattatca tattttgttt aacaatggtg ctcacgagtc tgtaggagga
     6481 cagcctactt taggatttag tttagatatt ccggctattg tccgggggag cggatataag
     6541 catacttata ctgtttgtac aaaagttgaa attgaagaag caatgaagca gcttccaaag
     6601 ttatgtggtc ctgttttgtt ggaaataaag gttaaaatag attctcggga gaatttggga
     6661 cgtcccacga ctactcctat agagaataag gagcatttta tggatttttt aaaataaata
     6721 tattcgatga aaatagaaag aaaaatatta ttaaatcctg ggcctgccac tactactgac
     6781 agtgtaaaaa tggcacaagt tgttccggat atttgtcctc gcgagaaaga attcgcaggt
     6841 atgatgaaac aacttcggga cgatttggtc agagttgctc atgggaattt ggaaaaacat
     6901 accgctgtat tattttgtgg ctcaggaacc atcaatattg atatatgtct aaattctctt
     6961 cttcctgaag acaaaagggt gcttatagtg aataatgggg catatagtac ccgtgctgta
     7021 gaagtgtgtc aatattatgg tttgcctcat attaatttgg aattttccgt ttacgaacgt
     7081 cctgatttat cggtggtgga aaatgtgttg caagaaaatc ctgatatagc tatggtttat
     7141 actactcatc acgagacggg tacaggaatt ctgaacccta ttcgcgagat gggcgctata
     7201 gctcataaat atcaggctaa atttgtcgtc gatactactt cttctttggg catgattcct
     7261 tttgatatag agaaagataa tgtggatttt tgtatggcat ctgctcaaaa aggacttcaa
     7321 gcgatgacag gtctttcttt tattataggc aatgaggaac agattaagtt ttcaaaaaaa
     7381 tatcccaagc gttcttacta ttgtaatctt tatttgcagt atgagaattt tgagagaaca
     7441 ggtgaaatgc attttactcc accggtacaa actatttacg ccactcgtca ggcattaaat
     7501 gaatattttg aagtgggtga agaagctaag tttgcccgtc acaaaagagt ttttgaggct
     7561 attcattcag gtataaatga aattggtctt aaaagtgtaa taaagcgtga atggcagtca
     7621 ggactggttg tctcagttca atacccagaa gatcccaact gggattttga gaaaatacat
     7681 gattattgtt atgagcgtgg atttacgatt tatccaggta agatatcaac tgaggatact
     7741 tttagaatct gtgctttagg agagatagaa gtagatgata ttgagaactt ctttaaagta
     7801 ctaaaagctg cattaaatca ttataacgtc acattaccga tgtcatgatt gcagaaatat
     7861 tattgaagat tcgtcatttt tatttttccc ttcgtggtat acacttccat ccggaaagtg
     7921 ttatttctgg agtgcctatt cgtagctttc gcttagtagg caaatatggc aatattaatt
     7981 tgaggtgatg cattaggagt tctttattct tataaaaagg catcggtagt tataggagat
     8041 aatgtttgtg tagggtaatt tgcttttagt gggagagacc atattagaat tgcggtaagg
     8101 ggcgaagaag ataataacca attagtgaga atattggaaa aatataattg atatcggtaa
     8161 atgtagttgt ttttatactg tatttaagta atggaaaatc taaagcagaa aactgtatca
     8221 ggaataatgt ggagcgctat agaacgtttc tctttacaag gagtacagtt tataattcaa
     8281 ataatattag ctcgtttgtt actaccatcg gattatggta tgatcgggat gttagctatt
     8341 tttcttcaag tcgctcaagt atttatagat agcggtttta caaatgcttt aatccagaaa
     8401 aaagatagaa ctgaagagga ttttgccact gtcttttatt ttaatattct tgtcgcagta
     8461 ttattctatg gtatattgtt tttttcggct tctttgattg cagactttta taatatgccg
     8521 actttagttc ttgtaattcg ttttatagca ttgtcgttga taataaatgc tttatcggct
     8581 attcacagaa cgaaattaat tatttctgta aactttaaaa ctcaatctaa aatttcatta
     8641 ggtgcagctt ttatatcagg cgtgattgga atatggatgg cttatgtcgg ttgcggggtt
     8701 tgggctttag tttggcaaac tctcttaaat agtataattt tgacaatttt gttttactgt
     8761 ttagttcatt ggaaaccttt acatactttc tccaaaagtt cttttgaaag attattcaat
     8821 ttcggatcta aattattgat ctcaagtctt atcaatacag tatatcgtaa tctgtatacc
     8881 attgtaatag gaaaaaagtt ttctgttgta gagcttggtt actatacaag agcagaacaa
     8941 tttgctattt ttccttccaa taatttaaat gctttagttt ctagagtagc gtatcctatt
     9001 ttaagttcca ttcaagatga tgataaatgt ttaacaaacg catatcgaaa ttatatcaga
     9061 ttatcctcat atataatttt tcctttaatg gtaggtttac ttgttttggc taatcctatt
     9121 attagtctat tgttaacaga taaatggtct ggggttgtta ttcttttaca gatattatgt
     9181 ttggattgga tgtttgatca tttgagccaa attaatttga atttattatg ggttaaagga
     9241 agatctgatc tgtcgttacg tcttgaaata ataaaaaaga cgattgctat attcattctt
     9301 tttgtgtcaa ttccatttgg gcttgaggtg atgtgttggg gtagagttat ttactctctg
     9361 atagcgacat atttgaatac atattatact aattctctta ttgatttgac cttaaagttg
     9421 caagttaaag atgtatttcc aagtttaata ctctctttca taatgggggg gatcgttttt
     9481 atatgtattt ctttctttga aactgatata gtaaaaattg tgattggatg tattactggg
     9541 atgtccttct atattttact ttcttttctt tttaagctag attctttttt ttgtatttta
     9601 acattgatca ttaaaactaa aaacatagat gaaaatatta aaaaagattt ttcaagtaat
     9661 agtaaagata attaaccatt gtgtgccagt tgatagtaga tcattgtatt ttattcctca
     9721 tcctaattgt agaacagata aatatgatat tataaattat tcgtcagata atgttctcgt
     9781 tctgttaaat tatttgctaa aaaaagatag tgctgaatat tataaaatat atgttgaaat
     9841 ttatgattct tctcgtattt cagaatatca agaatatatt tatggcataa atcctaatat
     9901 taggtgtact tttttatgtg catgtgttgg acgttttttc tttaataaag tatcttttaa
     9961 ggatatgttg tatgcctttt tttgtttttg tagagcaagt aaatgtttta cagctacttt
    10021 ttattatgat ttttcattta aaaaacgctc tcaacagatt atttgtttgg ggtattatac
    10081 tccattcaaa gatgattatc atatgggaga tcattcttat gataaatttc gtaatacaac
    10141 atgtaactca tttgattact ctattgctac ttcttgttta agtgctagaa taatttcaat
    10201 agattgtgga atctcatatg ataaattcaa agtcttagga tttcccagaa atgatttgtt
    10261 gatatcgaaa aataattgca atgttattaa aagagaaatt tcgaaatttg cgggatatga
    10321 tgtaactaaa tatatagttt atactccaac ttttcgtgat tatgagactg ttactgaagg
    10381 taatttgcgt tcaatactcg gatatgttga ttgtgatttg ttgaagttat cgaaaatact
    10441 attgaagttt aatgcggctt taattcttaa attacatcct ttgcagaata aaacagtctt
    10501 aaaaaaagat ttacccaaag gtatacttgt ttttgaacaa acatataaat atggattgta
    10561 tgatcttttg tcattttcag atggaatgat tactgattat acttctacct attttgattt
    10621 tttattggta aataagccag tcatatttaa tttctacgat attgaagaat atcgtagagt
    10681 aagaggtttc tcatttgagc caatagaatt tttttgtgca ggtgatattg tttacaatta
    10741 taatgaattg atagatgctg tgatgggact tctggctggg aaagatattc atgctgaaca
    10801 tcgacgtcat atttctttat tgatgaatca atttcaagat gataattcaa caaagagaat
    10861 atgtgacata tttttaaatg aaatataata aataaaatga attatgcatt tgtggtgcag
    10921 gcacgtttag gttctacacg tttgcctgga aaaatattga aacctttcta tggtaatcaa
    10981 tcgattcttg acttaatggt tcataagctt tctgctatat cgaatattcc agtaattatt
    11041 gctacaacaa attctgttat caatgaacct attgaaaaga aggcacttgc attaggggta
    11101 aagtgcttca gaggtgagga gaatgatgtt ttaaaacgat tcattgatgt tgctgaatat
    11161 tttgatatac agggtatatt ccgaatatgt tctgataatc catttttaga tgtacatgcg
    11221 gcaaggcaat tggtcgaaat agcaatgaaa tcttgtaacg attatataag ttttgatatt
    11281 gatggtactc catcaattaa aactcatttc ggtttttggg gagaatttgt aacgcttgat
    11341 gcgctgaagc gagttatagg atttactgat gatttattgt atcgtgaaca tgttactaat
    11401 tatatatata gtcatcctga actttttaat attcaatgga tttcaggatc tccagtcgtg
    11461 tcaaaacatc ataatattcg actcacgatt gatacgttag aagatttttc tgtagcacag
    11521 agaatatata gggatttaca agaaaaaaga gtggaaatat cgatagaagt gattgtagac
    11581 tatgttcgaa gacatgcaga atacattcaa ctgatgaaac aacaaataaa aaaaaattct
    11641 aaataatgaa gaatacttat attattggtg aaatagggca gaatcataat ggttctgttg
    11701 acttggctaa gttgattatt gaattaatct cacgacctgt acatgaggat gtttttggta
    11761 tggatttcat gccaatgaat gctgttaaaa tgactaaaag agatttatca gaagaattgg
    11821 ctgtttctca aatgaatcaa atatatgaca atcctaattc ttttgggcgt acttatggtg
    11881 aacatcgtgc ttttcttgag cttgatgatc aagcgcattt tgagatttat aaatatgcta
    11941 agtcattagg attagatttt atcgagacgt tatgtgccaa aggatgtctg tctttgctta
    12001 aactgttcac accggatagg ctaaaagttg ctagtcgtga tttgactaac ttaccattgc
    12061 ttgaagcatt agcagaaact catattccta ttatattatc gacaggaatg gctggtcaaa
    12121 gagaacttga caatgcatta gatgtgataa cgagatatca tagtaatata gctattctac
    12181 attgtgtatc tcagtatcca actcatccaa ataatttgaa tctacgtaca ataacatatt
    12241 tgaagaagca ttacaataag tttgagatag gtttttctga tcatacaata ggtatttctg
    12301 ctgctacagc tgctgtagcg atgggagcgg aaattataga aaagcatgta acaattgatc
    12361 ggcatatgaa aggaacagac cagcttggct ctttaggtcc agatggggtt aatcgtatga
    12421 ttcgagatat tcgcatagca gagtgttggc ttggtactga agatctttat atagaaaaag
    12481 gggtggagaa gtctaagata aaacttgaac gttctattgc cactcgaaaa tatattccag
    12541 caggtagtat tattcaagag tcggacattc atttactgag tcctggtgat ggttataaat
    12601 ggatagataa aaaaaatgta attggtcatt ttgctaaaca agatatatca gcgaatgaaa
    12661 taatatatcc tgattttatt gaatagatat attcctactg caacttgtat tacggtatag
    12721 agtactgcct gctataagct aagtagtgat taataaataa gggtaaaata ctaaaaaaat
    12781 gaaagagata aagcttatac ttacagatat tgatggcgtt tggactgatg gcggaatgtt
    12841 ttatgatc
//
