LOCUS       gnlProkkaDFLJLCLK_16   14265 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DFLJLCLK_16.
ACCESSION   gnlProkkaDFLJLCLK_16
VERSION     gnlProkkaDFLJLCLK_16
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 17:37:44
            Original ID  :: gnl|Prokka|DFLJLCLK_16
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 567861
            Orig. end    :: 582126
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14265
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:9265]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9265
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..14265
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14265
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(413..1465)
                     /NRPS_PKS="Domain: NAD_binding_4 (4-199). E-value: 8.1e-12.
                     Score: 36.6. Matches aSDomain:
                     nrpspksdomains_ctg16_525_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     301.5; E-value: 1.2e-91)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_525"
                     /sec_met_domain="RmlD_sub_bind (E-value: 7.3e-16, bitscore:
                     53.4, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 6.9e-13,
                     bitscore: 43.7, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVLVTGAAGFIGSHVCKRLLQRGDEVVGLDNINSYYDINLKYGR
                     LSSLGVSQSELSWYKFTRSNVYPRFSFVRMNLEDRQAMQMLFANGNFDVVINLAAQAGV
                     RYSIENPYAYVESNIDGFLNVLEGCRHSQVKHLVYASSSSVYGLNGQVPFSEKDGIAHP
                     VSLYAATKKSNELMAHTYSHLYNIPSTGLRFFTVYGPWGRPDMSPFLFADAILHGRPIK
                     VFNNGNMLRDFTYIDDIVEGVLRVADSIPEGNQCWDAEVADPSMSCAPYKIYNIGNSRP
                     VKLMDFIRAIEMSIGREADKIYLPMQPGDVYQTYADTSSLSREIGFQPNTSLEAGVKET
                     ISWYKEFYNL"
     aSDomain        complement(869..1453)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg16_525_NAD_binding_4.1"
                     /evalue="8.10E-12"
                     /label="ctg16_525_NAD_binding_4.1"
                     /locus_tag="ctg16_525"
                     /protein_end="199"
                     /protein_start="4"
                     /score="36.6"
                     /tool="antismash"
                     /translation="VTGAAGFIGSHVCKRLLQRGDEVVGLDNINSYYDINLKYGRLSSL
                     GVSQSELSWYKFTRSNVYPRFSFVRMNLEDRQAMQMLFANGNFDVVINLAAQAGVRYSI
                     ENPYAYVESNIDGFLNVLEGCRHSQVKHLVYASSSSVYGLNGQVPFSEKDGIAHPVSLY
                     AATKKSNELMAHTYSHLYNIPSTGLRFFTVYG"
     CDS_motif       complement(1394..1456)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg16_525_0001"
                     /evalue="2.20E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg16_525"
                     /protein_end="24"
                     /protein_start="3"
                     /score="13.9"
                     /tool="antismash"
                     /translation="LVTGAAGFIGSHVCKRLLQRG"
     CDS             complement(1473..2342)
                     /locus_tag="ctg16_526"
                     /transl_table=11
                     /translation="MIVSSLRGGLGNQMFIYAMVKAMALRNNVPFAFNLTTDFANDEVY
                     KRKLLLSYFALDLPENKKLTFDFSYGNYYRRLSRNLGCHILHPSYRYICEERPPHFESR
                     LISSKITNAFLEGYWQSEKYFLDYKQEIKEDFVIQKKLEYTSYLELEEIKLLDKNAIMI
                     GVRRYQESDVAPGGVLEDDYYKCAMDIMASKVTSPVFFCFSQDLEWVEKHLAGKYPVRL
                     ISKKEDDSGTIDDMFLMMHFRNYIISNSSFYWWGAWLSKYDDKLVIAPGNFINKDSVPE
                     SWFKLNVR"
     CDS             complement(2339..3484)
                     /locus_tag="ctg16_527"
                     /transl_table=11
                     /translation="MKILLVFIDMIRVDHLSLYNDNMEKTSLDLFFENLGGTILTNCYT
                     PAPDTPRSIACLQSGLLPYLNGCDSRVKWPRYFMKPNIETIFDIAVGLGYKVNLCATKS
                     DIETGLFKFKENENISIFTTIEDFTDTVHLSENTLSLIAIDDYHSAIDDYGGTSLGIKE
                     GQKVILYSLNNFLTPDIVNKYDYSFFFSDHGHALQSEIVMQKNKLELLSDGRTKLFMFY
                     HNINNKKIVKDSRLASILDLYASIVDLIGSGDFRQGFSFFRDSQRDILHIEDHADFRVS
                     PEQIVSQWRVISDEIDIRTNVFETLNKKGQIIDINVVKKYLDSFSPSFSYYMKQIEILK
                     MYEKMKQRKTHYFNGVKRANWWIRCYVRIINRLYILINRLK"
     CDS             complement(3488..4981)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_528"
                     /sec_met_domain="Polysacc_synt (E-value: 2.7e-09, bitscore:
                     32.2, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDKKNVVKWNFVFYLLEFLYTILVGIILVPLYLKYIPKDLYGFW
                     LATGNILSILTLINPGFSDVIQQKVAYCYGLHDYKKIGLYTVSGICLTFVFSLIVLIIG
                     VVVNLLIGSIFTMQANYLYELKIAFGLMLVGTFLTINYYSFSSILYAFLSSKSIGLIVL
                     LGNSLGTLISIYLIIHGYGLIALGIASVVRGGVFLSCSVGYVIFKFRKKKIKIVFDLNN
                     VKEIFSFSIYNFLGKTGQTLLTNMNSFLTAKFVSPIDAANLRFTQTVPEFGKVLVLRFL
                     YSVAPIIPNLLAAKGLESIRIKLLNIVYFLISFIFLVCIGFYLLNEQFIYLWLGENNFS
                     GKIINFFIIILLFFSSINKVCFQFLFALGDIKKSNKILFYQSLLYLPIAVFTTKFCGII
                     GLLLSGILVELLALFIFFFPKMVDILNISKIDIRKKLFVELTKISFVTVITLLIGSCVK
                     FSNPSWLLFFVEIVFIVLTFFVLLFLCSKTFRNLLSICK"
     CDS             complement(5001..6101)
                     /NRPS_PKS="Domain: Aminotran_5 (30-293). E-value: 6.2e-34.
                     Score: 109.3. Matches aSDomain:
                     nrpspksdomains_ctg16_529_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 80.5; E-value:
                     1.9e-24)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_529"
                     /sec_met_domain="Aminotran_5 (E-value: 5.2e-30, bitscore:
                     99.9, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIERKILLNPGPATTTDTVKLAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGDLSKHTAVLFCGSGTINIDICLNSLLPADKKVLVVNNGAYSTRAVEVCEYY
                     GLPHIDLKFSVYELPDLSVIEKTLSDNPDIALVYTTHHETGTGILNPIREIGKIAHSHG
                     AVFVVDTTSSLGMIPFDIGKDNVDFCMASAQKGLQAMTGLSFIIGDESLIRASRDYPKR
                     SYYCNLYLQYDYFEKTGEMHFTPPVQTVYAARQALDEYFAVGEEAKFARHKRVFEAIHK
                     GLQELGLQYAIKREWQSGLVVSVLYPDDPLWDFDKVHDYCYERGFTIYPGKISTTNTFR
                     LCALGEIDVEDIERFFEVMREAVLKY"
     aSDomain        complement(5223..6011)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg16_529_Aminotran_5.1"
                     /evalue="6.20E-34"
                     /label="ctg16_529_Aminotran_5.1"
                     /locus_tag="ctg16_529"
                     /protein_end="293"
                     /protein_start="30"
                     /score="109.3"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGDLSKHTAVLFCGSGTINIDICL
                     NSLLPADKKVLVVNNGAYSTRAVEVCEYYGLPHIDLKFSVYELPDLSVIEKTLSDNPDI
                     ALVYTTHHETGTGILNPIREIGKIAHSHGAVFVVDTTSSLGMIPFDIGKDNVDFCMASA
                     QKGLQAMTGLSFIIGDESLIRASRDYPKRSYYCNLYLQYDYFEKTGEMHFTPPVQTVYA
                     ARQALDEYFAVGEEAKFARHKRVFEAIHKGLQELGLQYAIK"
     CDS             complement(6098..7234)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 70.6;
                     E-value: 1.9e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_530"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1e-20, bitscore:
                     69.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.3e-19, bitscore:
                     64.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSVEKIYDTFLHHGVDFFTGVPDSLLKNICAYITDHAPRGKHII
                     AANEGSAVGIACGYYMASGNVPLVYMQNSGLGNTVNPLLSLADEKVYSLPLLLLVGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMKIPFIILDTDEDEALAQIHDAVVSAKSRSIPHAIV
                     IRKDTFGKYKLRQEALNDYPLSREEALMQVVDHLGDNDIVVSTTGKLSRELFEYRESKG
                     QGHARDFLTVGSMGHSSSIALGIALEKPDRRVYCLDGDGAFIMHMGAVSNIGDLSPKNY
                     RHVLFNNGAHESVGGQPTLGFRLDIASIAKGCGYAHVLTASDKEGLSCALEKLSGLSGP
                     VLLEIKVRIDSRDDLGRPTTTPVENKEHFMAFLKDTHS"
     CDS             complement(7246..8547)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 214.1;
                     E-value: 3.9e-65)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_531"
                     /sec_met_domain="CTP_transf_like (E-value: 8.5e-11,
                     bitscore: 37.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 6.2e-121, bitscore:
                     398.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 3.1e-63, bitscore:
                     208.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKIYVGMTADIMHPGLIHIIHEATKYGDVIVGLLTDKAIAEHK
                     RLPYLTYDQRKEVVENIKGVFEVVPQEDWSYVPNLEKLKPDYIIHGDDWKTGPLREVRE
                     QVFEVMNAQGGKVIEIPYTRGINSSSLDKDIKAIGTTPDVRLKSLRRLIQAKPVVRILE
                     AHDGLCGLIIENLEVQKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAVIIEDKVGLKKNSLFGTDAIQTQDS
                     IEGFCDKIRAGKNAQVTGDFMIIARIESLIAGKPMSDALERAYAYVQAGADGIMIHSKD
                     KSGEDIREFCRTFRKEYAHVPIVVVPTTYDHVHESELHEWGANVVIYANHLLRAAYPAM
                     MNVARTILENERAEEVRPLCMPIKEILELIPGTK"
     CDS             complement(8567..9265)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_532"
                     /sec_met_domain="NTP_transf_3 (E-value: 7.8e-13, bitscore:
                     44.4, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAGLGTRFGHYTELVPKGFVEVGGKPMIIRSIETLLSCGIERII
                     LGTGYKKEAYEALQADFPQIETCFSPRYADTNSMYTLYNTRDVIGDDSFLLLESDLVFE
                     RKAILSLLDDEFPDVMLVSSLTKFQDQYYVEYDRNHILTSCSVDKNALEAKGELVGIHK
                     LSNTFYRRMCADYATILESQPKLGYEYELLRMSRSVSPVRVLRVEGLKWYEIDDEADLS
                     YAEEHIIRYC"
     CDS             complement(9279..10562)
                     /locus_tag="ctg16_533"
                     /transl_table=11
                     /translation="MIRSFLSRSPLYVLALYASVLIFLVYTCAYAYRKPFTAAIYEGEI
                     LWGFDVKILYVLSEIIGYALSKFIGVRILPSMKAGHRIYYIIGLLTFSEVALLGFALLP
                     VPLKVCSIFLSGLPLGMIWGVIFSYIEGRRISEILNVGLSVALIVSSGLVKTLGQFVMD
                     NLHVSEYWMPFTTGLLVYPVMLLCSWLLNQIPAPNEQDIIQRTKRAPMDGKDRRKFLRQ
                     FFWGICMLVVFYGALTVFRELRDSFAADIWKELHIEGAMIFTQTEVPIAVFVLVLMFLI
                     VFVRNNRLALNIIYCIAVTGGSLMVFSTLLYVYGFLSPIWWMILSGLGLYMGYIPFTYL
                     IERLIASLRVVSTAVFIIYLADSFGYLGTTGVFMVKNFVSADISWTVMLMRTALFSGFV
                     SVLSIFAIYCYFKQQLNSLILIPSEIHD"
     CDS             complement(10559..11044)
                     /locus_tag="ctg16_534"
                     /transl_table=11
                     /translation="MNTLTSQIEQLQSLAHELLYLGVDGAPIYTDHFRQLNKEVLEQSD
                     ALYPQRGATPEEEANICLALLMGYNATIYNQGDKEEKKQVVLNRCWDVLDQLPATLLKC
                     QLLTYCYGEVFEEELAKEAHTIIESWSNRELLKAEKEIAESLNNLEANPYPYSELHE"
     CDS             complement(11048..11572)
                     /locus_tag="ctg16_535"
                     /transl_table=11
                     /translation="MSEQQKYWFAARTRDKQEFAIRDSLEKLKTELDLNYYLPTQFVIR
                     QLKYRRKRVEVPVIKNLIFIQATKQDACDISNKYNIQLFYMKDLLTRAMLIVPDKQMQD
                     FIFVMDLDPNGVSFDNDHLSVGSRVQVVKGDFCGVEGELASEANKTYVVIRIAGVLSAS
                     VKVPKSYLRVI"
     CDS             12094..12432
                     /locus_tag="ctg16_536"
                     /transl_table=11
                     /translation="MNDNLVTIEVNGKVIFAGKADLQFSLNQKVREPLRITKGKGKLME
                     ALTESFIKGGINSMENRPIEELQETIKEYLTFEYQRKGIATEPNKRSFLSELKKYARAF
                     RKKRDESE"
     CDS             12573..12920
                     /locus_tag="ctg16_537"
                     /transl_table=11
                     /translation="MKKNRKAVSKNEMMKGKWKRQIMLEKDYTEQCSEWMAERLEALIE
                     YMQYGHAAVAYMKQDGTFKLVKGTLVGYEKDFGKQYDPMEIKNTVVYRDVEQQRWMTFK
                     IENFMEWRAIV"
     CDS             12970..13773
                     /locus_tag="ctg16_538"
                     /transl_table=11
                     /translation="MATTYDGINYFPIAVNFMEENAMEVIEAKYGMKGLAIVLKLLCKI
                     YKEGYYIPWGEEQCLIFANKTGKEADAEEVQGIIEIMIEKGMIDRGSYAEHKVLTSEAI
                     QKVWIEATKRRKRNWTAMPYLLIKPKETCNEEKTVCTQNVEQDAGSDAKNACNTEQSKV
                     KQSREFPPSAPPRGKEEEVNATPVSMPGYAFNTMTHNYVGLMGNLERFGITDEKEIEAI
                     LRLSDYGRKGTPVWKLICSTNWSNIGAKGKYMIAALNRAKKRSGT"
ORIGIN
        1 tcaccccgga tcgtagcttt cacctgttgc gctgtgccga caggaacagt actcttcgtt
       61 accaccagta cataatggtt catcgtttta ccaatcgtac gggcaacttc aagcacatac
      121 tttaaatccg cactgccatc ttcatcagga ggagtaccaa ctgcactaaa cacaacctca
      181 acatcattca aacatgaggc taaggaagta gtgaacttca aacgccccgc attgtaattg
      241 cggtgcacca tgtcttcaag tcccggctca tagatcggaa ttatgccttt tttaagatta
      301 tcaattttag attcaatcac atcaacgcat gtgacgtcta ctcccatctc agagaaacag
      361 gtacctgtaa ccaaaccgac gtaacctgta ccaactatag caatcttcat aattatagat
      421 tataaaattc tttataccaa cttattgttt ccttaacgcc cgcctccaag gacgtattgg
      481 gttgaaaacc aatttcccgc gaaagagaag aagtatccgc ataggtctga tacacatccc
      541 cgggctgcat cggaagatag atcttgtcag cttccctccc gattgacatt tctatagcac
      601 gtataaaatc catcaatttt acaggacggg aattaccaat attataaatc ttatagggag
      661 cacaggacat gcttggatcc gcaacctcag catcccagca ctggttccct tccggaatag
      721 aatcagccac tctcaagaca ccttccacaa tatcatctat atatgtaaaa tcacgaagca
      781 tgttgccatt gttaaagacc ttgatggggc gaccatgcaa gatagcatcc gcaaatagaa
      841 aaggagacat atccggtcta ccccagggac catataccgt gaagaaacga agacccgtag
      901 aaggtatatt atataaatgg ctataagtat gtgccataag ttcattcgac ttcttggttg
      961 cggcatacag actcaccgga tgggctatgc catctttctc tgaaaaagga acctgtccat
     1021 tcaaaccata tacactactg gaactggcat aaaccaaatg tttcacttga ctgtgacgac
     1081 aaccctcgag aacattcaga aaaccgtcta tattactttc aacataagca tatggattct
     1141 caatggagta gcgcactccc gcttgtgcgg ccaaattgat tactacatca aaatttccat
     1201 tagcaaacag catttgcata gcctgcctat cctcgaggtt catccgcaca aaactaaatc
     1261 gaggataaac attactccgt gtgaacttat accatgacag ttcagattga gaaacaccta
     1321 agctcgaaag gcgtccatac tttaaattaa tatcataata cgaattgata ttatccaaac
     1381 ccacaacttc atccccacgt tgcaaaagac gcttacaaac atgcgaacct ataaatccgg
     1441 cagcaccggt tactaataca ttcattaaga ttttatctta cattcaattt aaaccaagat
     1501 tctggtacag aatccttatt tataaaatta cctggagcaa tcaccagctt atcatcatat
     1561 ttcgaaagcc atgctcccca ccagtaaaaa gagctattcg atattatata attacgaaaa
     1621 tgcatcatta gaaacatatc atctatagta ccactatcat cctccttttt acttatcaaa
     1681 cgaacaggat attttcccgc tagatgtttt tcaacccatt ctaaatcttg tgaaaaacaa
     1741 aagaaaacag gagaagtaac ttttgatgcc ataatatcca tagcacattt atagtaatca
     1801 tcttctaaca ctccaccagg agctacatca ctttcctgat accgtctaac cccaatcatt
     1861 atggcattct tatctagcaa ttttatttct tccaattcca aatacgatgt gtattctaat
     1921 tttttttgta ttacaaagtc ctcttttatc tcttgtttat aatcaagaaa atatttttct
     1981 gactgccaat atccttccag aaaagcattt gtaatcttag aactaattaa ccttgattca
     2041 aagtggggag ggcgctcttc gcaaatataa cgatatgatg gatgaagtat atgacaacct
     2101 aaattacgac ttagccttct ataataattc ccatatgaaa aatcaaatgt taatttttta
     2161 ttttcaggca agtctaatgc aaaatatgat aataaaagtt tccttttata aacttcatca
     2221 tttgcaaaat cagtagtcaa attaaaagcg aatggtacat tgtttcttaa tgccatggcc
     2281 ttcaccatag cgtaaataaa catttgattc cccaatcctc ctcgcaaaga tgatacaatc
     2341 atttcaatct atttattagt atatataacc tatttataat tctaacataa cagcggatcc
     2401 accaattagc tcgctttacc ccattaaaat aatgcgtttt ccgttgtttc attttctcat
     2461 acatttttag aatctctatc tgtttcatat aataagaaaa cgagggggaa aaactatcta
     2521 aatatttttt taccacattt atatcgatta tttgtccttt tttatttaaa gtttcaaata
     2581 cattagtcct aatatctatt tcatctgaaa ttactcgcca ttgactcaca atttgctctg
     2641 gagacaccct aaaatcagca tggtcctcta tatgaagtat atctctttga ctgtctctaa
     2701 aaaaggaaaa accttgccta aaatctccac taccaatcaa atcaacaata gaggcataaa
     2761 gatccaaaat agaagcaagc ctagaatctt ttactatttt cttattatta atattatgat
     2821 agaacataaa aagtttagtt cttccatcac taagtagttc tagtttattt ttttgcatga
     2881 caatttcact ctgcaaagca tgcccatggt ctgaaaagaa aaacgaatag tcgtatttat
     2941 ttacgatatc tggagttaga aaattattta aagaatataa tatcactttc tgcccttctt
     3001 taattcccaa tgaggttcct ccataatcat caatggcaga atgataatca tcaatggcaa
     3061 ttaaggacaa tgtattttct gacaaatgaa cagtatcagt aaaatcttca atagtagtaa
     3121 atatactaat attttcattt tctttaaact taaacaaccc tgtttcaata tcagatttag
     3181 tcgcacacaa atttacttta tatcctaacc ctactgcaat atcaaaaata gtttctatat
     3241 taggtttcat aaaatatctt ggccatttga cacgactatc gcagccattc aaatagggta
     3301 ataggccact ttgcaaacaa gctatacttc ttggagtatc aggtgcaggt gtataacagt
     3361 tagttagaat tgtacctcct aaattttcaa aaaacaaatc caacgatgtt ttctccatgt
     3421 tatcattata taatgataaa tgatcaacac gtatcatatc tataaaaact agtagtatct
     3481 tcatctttta tttacaaata gacaataaat tacgaaaagt ctttgaacat aaaaacaaca
     3541 aaacaaaaaa tgttaataca ataaaaacaa tttccacaaa gaaaagtagc caactaggat
     3601 tagagaactt gacacaagaa cctattaata atgtaataac cgtaacaaaa gatattttgg
     3661 ttaactccac aaaaagtttc tttctaatat ctattttcga aatattaaga atatcaacca
     3721 ttttaggaaa gaagaaaatg aatagtgcca ataattctac taatattcca gataacaata
     3781 aaccaattat tccacaaaat ttcgttgtaa aaacagcaat aggtaaatac aacaaagatt
     3841 ggtaaaataa aatcttattg cttttcttta tatctcctaa tgcaaaaaga aactgaaaac
     3901 agaccttgtt tatagaagaa aaaaacaata aaataatgat aaaaaaatta attattttcc
     3961 ctgaaaaatt gttctcacca agccataaat atataaattg ttcattcaat agataaaaac
     4021 caatacatac taagaaaata aaggaaatca aaaaatacac aatattcaaa agctttattc
     4081 taatagactc caacccctta gctgctaaca aattaggaat aataggagca acagaatata
     4141 aaaatcttaa aactaaaact ttaccaaatt ccggcacagt ttgagtaaat ctcaaatttg
     4201 cagcgtcaat aggagaaaca aacttagcag tcaagaaaga attcatatta gtcaacaatg
     4261 tttgtcctgt tttacctaaa aaattatata tagaaaaaga aaagatctcc ttaacattat
     4321 ttaaatcaaa tacaattttt attttctttt ttcgaaattt aaatattaca tagccaacac
     4381 tacatgacaa aaaaacacct cctcgaacaa ctgatgcaat tcccaaagct attagaccat
     4441 atccatggat aataagataa atagatatta aagtacctaa actattgcct agaagtacaa
     4501 ttagcccgat tgacttacta ctaagaaaag catataatat agaagaaaag gaataataat
     4561 taatagttaa aaatgtacca acaagcatta agccaaaagc tatttttaat tcatataaat
     4621 aattagcttg cattgtaaat atactaccta ttaaaaggtt aactactact ccgattatca
     4681 aaacaattaa tgaaaaaaca aacgtaagac aaatacctga aacggtatat aatcctattt
     4741 ttttataatc atgtaatcca taacaatatg caactttttg ttgtatcaca tctgaaaacc
     4801 caggattgat aagagttaaa atagacaata tattaccagt agctagccag aaaccatata
     4861 aatcctttgg aatatatttc aaatacaacg gaaccaaaat aatcccaact aaaattgtat
     4921 acaaaaattc caagagataa aatacaaaat tccattttac tacatttttt ttatctttca
     4981 tatcccaatt gacaatttct ctagtatttt aaaacagcct ccctcatcac ctcaaagaac
     5041 ctctcaatat cctccacatc aatctctccc aacgcacaaa gccggaatgt attcgttgtg
     5101 gaaatcttac ccgggtagat cgtaaagcca cgttcatagc agtaatcatg aaccttatca
     5161 aaatcccaga ggggatcatc aggatacaat acagaaacaa caagacccga ctgccattca
     5221 cgtttgatcg catactgaag accaagctct tgcaaacctt tatggatggc ttcaaagacc
     5281 ctcttgtgac gggcgaattt agcctcttca cctactgcaa aatattcatc aagagcctga
     5341 cgggcagcgt aaacggtttg aacaggagga gtaaaatgca tctcacccgt cttctcaaag
     5401 taatcgtatt gtaaatagag gttacaatag taggagcgtt tcggataatc ccttgaagca
     5461 cgtatcaggg attcatcacc tatgataaag gaaagacccg tcatggcctg aaggcctttc
     5521 tgagccgaag ccatacaaaa gtcaacatta tccttcccga tatcaaaagg aatcataccc
     5581 agggaggaag tggtgtcgac aacaaaaacg gcaccgtgcg aatgggctat ttttccgatc
     5641 tcacggatgg ggttcaagat acccgtaccc gtttcatggt gcgtggtata gaccaaagcg
     5701 atgtccggat tgtcggaaag cgtcttttcg attaccgaca ggtcgggaag ttcgtaaacg
     5761 gaaaacttca aatcgatatg gggaagaccg taatattcgc agacttccac cgcacgggtg
     5821 ctataggcac cgttattgac aaccagaact ttcttatccg caggaagaag agagttcagg
     5881 cagatatcga tattgatcgt acccgagccg caaaacagga cggccgtatg tttggagagg
     5941 tctccatgcg caacgcggac caggtcgtca cgtaactgtt tcatcatacc cgcaaactct
     6001 ttctcacgcg gacagatatc gggaacaacc tgcgccagct ttaccgtatc cgtcgtggtg
     6061 gcgggacccg gattcaaaag gatctttctt tcgatattca tgaatgcgta tcttttaaaa
     6121 atgccataaa atgctcttta ttctctaccg gagtagtcgt agggcgaccc agatcatcac
     6181 gtgaatcgat ccggacctta atttcaagaa gaaccgggcc ggacaggccg gacagcttct
     6241 caagcgcaca cgaaagccct tccttgtcgg aggcagtcag tacatgcgca taaccgcaac
     6301 ctttcgctat cgaggcgata tccagacgga aaccgagcgt gggttgaccg ccgacagatt
     6361 catgcgcacc gttgttgaaa aggacgtgcc tgtaattctt gggagaaaga tcgccgatat
     6421 tgctgacagc acccatgtgc atgataaagg caccgtcacc gtcaagacag tagacacggc
     6481 ggtcaggctt ctcaagggca atccccaggg caatggaaga actgtgaccc atggaaccca
     6541 cagttaggaa atcccttgcg tgcccctgcc ctttcgattc acggtactcg aaaagctcac
     6601 gggagagctt gcccgtggtg gaaaccacaa tgtcattgtc cccgaggtgg tcgacaacct
     6661 gcattagcgc ctcctcgcgg gacagaggat agtcattcaa ggcttcctga cgcaatttat
     6721 attttccaaa cgtatcttta cggatgacaa tcgcatgggg aatcgaccgg ctcttcgccg
     6781 agacaaccgc gtcatggatc tgcgccaggg cctcgtcttc atccgtatcc agaattataa
     6841 aaggaatttt catggctttc agaagatcaa gggtaacctc gccctgcttc ttatgctggg
     6901 gttcgtcttt tgtgccgggc tcaccgcgcc agccgaccag caaaagaaga ggaaggctgt
     6961 acactttctc gtccgcaagg gacaagaggg gattcaccgt atttcccaga ccggagttct
     7021 gcatataaac caaaggaacg ttgccagaag ccatataata accgcaggca atgcccaccg
     7081 cggaaccttc attggcggcg atgatatgct taccacgcgg agcatgatcc gtgatatagg
     7141 cgcaaatatt cttcaaaagg gaatcgggaa cacccgtaaa gaagtcaaca ccgtgatgaa
     7201 ggaacgtatc gtatatcttt tctacactta ccataaccgt ctgatttatt tagtgcccgg
     7261 aatcaattcc agaatttcct tgataggcat acaaagcgga cggacctcct cggcgcgctc
     7321 gttttcaagg atggtcctgg ccacgttcat catggccggg taagcggcac ggagaaggtg
     7381 gttggcgtaa atgactacgt tggcacccca ttcgtgaagt tcggattcgt gcacatggtc
     7441 ataagtcgtc ggaacaacga caatgggaac atgggcgtat tctttgcgga aagtccggca
     7501 gaactcacgg atatcctcac ccgacttatc cttgctgtgg atcatgatgc cgtccgcacc
     7561 cgcctgtaca taggcataag cacgttcgag ggcgtcactc atgggtttgc cggcaataag
     7621 gctttcgata cgcgcaatga tcataaagtc accggtgacc tgggcattct tccctgctct
     7681 gatcttatcg cagaaaccct cgatactatc ctgagtctgg atagcgtcag taccaaaaag
     7741 ggaattcttc ttcagaccga ctttatcttc aatgattact gcagaaatgc catgacgttc
     7801 cagagtgcgc acagtaaaga caaagtgttc gatcttgcca cccgtgtctc catcaaaaat
     7861 aataggcttg gtggtacatt caaggatatt gttcaggtcc tgtaaacggg tggtaaggtc
     7921 gaccgcttca atatccggtt tacccttact cgtggagtcg gtcaggctgc tggaccacat
     7981 gccgtcaaag acctcgcgct tatccccctt ctggacttca agattctcaa taatcagacc
     8041 gcaaagaccg tcgtgagcct ccaggatacg gaccacaggc ttggcctgga tcaggcggcg
     8101 gagggactta agacgtacgt caggggtagt cccgatcgcc ttgatatcct tgtcgagcga
     8161 ggaggagttg atgccccggg tataagggat ctcgattacc ttgcccccct gggcgttcat
     8221 cacctcaaaa acctgttcgc gcacctcgcg caacgggccc gttttccagt cgtcgccgtg
     8281 gatgatatag tcaggcttga gtttttccag attcggaaca tagctccagt cctcctgggg
     8341 aacaacctca aaaaccccct tgatattctc aacaacctcc ttacgctgat cataggtaag
     8401 gtaagggagg cgtttgtgtt cggcgatggc cttgtccgtc agcagaccga cgatgacatc
     8461 accgtattta gtagcttcat gaataatatg gatcagcccc ggatgcatga tatccgcggt
     8521 cataccgaca taaattttct tgttcatata tggaaaagat ttgtttttaa caatagcgga
     8581 tgatgtgctc ctcggcatac gaaaggtcgg cttcatcatc gatttcatac catttaagac
     8641 cctccaccct gagcacacgg acaggggaaa cggaacggga catgcggagc agttcgtatt
     8701 cgtaacccag tttaggctgg gactccagga tggtcgcata atcggcgcac atccggcggt
     8761 agaaagtatt ggaaagttta tggataccga ccagctcgcc ttttgcctca agggcgttct
     8821 tgtctaccga acaggaagta aggatgtgat tgcggtcata ttccacataa tactgatcct
     8881 ggaacttggt cagagaagag acaagcatca catccgggaa ttcgtcatcc agcagcgaaa
     8941 ggatggcctt gcgttcaaaa acaaggtccg attcaagcag caggaaactg tcatcgccta
     9001 tcacgtcacg cgtattgtac agagtgtaca tactgttagt atcggcataa cggggactga
     9061 aacaggtctc tatctggggg aaatccgcct gaagggcttc ataagcctct tttttataac
     9121 ccgtaccgag gatgatacgt tcgataccgc aggaaagaag ggtttcgata gagcggataa
     9181 tcataggttt tccaccaacc tccacaaaac ctttgggcac aagctcggta taatgcccga
     9241 agcgggtacc aagaccggca gccatgatca ttgctgtttt aatcatgaat ttcagaggga
     9301 attaatataa gtgaattcaa ttgttgcttg aaataacagt aaatcgcaaa aatcgacagg
     9361 acagaaacaa atcctgaaaa aagggcagta cgcattagca tgacagtcca ggaaatgtca
     9421 gcagaaacga agttcttgac cataaacaca cccgtagtgc ccagatagcc gaaagaatcg
     9481 gccaaataaa taataaaaac agccgtacta accaccctaa gggaagcaat cagacgttct
     9541 atcaggtaag tgaaaggaat ataccccata tacagaccaa gaccggaaag aatcatccac
     9601 caaataggag aaagaaaacc gtacacataa agcaatgtgg aaaaaaccat taaggaaccg
     9661 cctgtgacgg caatgcaata aatgatatta agagccaaac ggttattacg gacaaacaca
     9721 atcaggaaca tcagtacaag gacaaaaacg gcaatgggaa cctctgtctg agtaaagatc
     9781 attgcaccct caatatggag ctccttccaa atatcggcag cgaaagagtc acgaagctca
     9841 cggaacacgg tcagggcacc gtaaaaaaca accagcatgc agattcccca gaagaattgc
     9901 ctcaaaaatt tacgcctgtc tttaccatcc atcggagcac gtttggtacg ctgtatgata
     9961 tcttgctcat tgggagccgg aatctgattg agaagccagc tgcaaagcaa cataacaggg
    10021 tataccaaca aacctgtggt aaaaggcatc caatattccg acacatgcaa attatccatc
    10081 acgaattgtc ccaaggtttt caccaaaccg gaagagacta tcaaagcaac gctcagcccg
    10141 acattcaata tttcactgat acgacgccct tcgatatagc taaaaatgac accccagatc
    10201 atacccaggg gaagaccgct cagaaaaata gaacacacct tcaaaggaac cggaagaagt
    10261 gcaaaaccca acaaagcaac ttcggaaaaa gtaagcagcc ctattatata atagatgcgg
    10321 tgacccgctt tcatcgaagg caaaatacga acaccgatga acttggaaag ggcgtagccg
    10381 ataatctcag aaaggacata cagaattttg acatcgaatc cccaaagaat ctcaccttca
    10441 taaatggctg cggtaaatgg cttacggtag gcataggcac aagtataaac cagaaaaatc
    10501 aaaacgctgg catagagagc caaaacgtaa aggggagaac gggaaagaaa ggaacgaatc
    10561 attcgtgtag ttcgctgtac ggatatggat tagcttccaa attattcaaa ctttcagcta
    10621 tttctttttc agcttttaaa agttctcgat tgctccaact ttctatgata gtatgcgcct
    10681 ctttcgccaa ctcctcttca aacacctcac cataacaata agtcaataac tggcatttca
    10741 ataaagtagc aggaagttgg tcaagcacgt cccaacaacg attgagaaca acttgctttt
    10801 tctcctcctt gtcaccctga ttatagatgg ttgcattgta acccatcaat aatgccagac
    10861 agatgtttgc ttcctcttcg ggagtagcac cacgctgagg atacaacgca tcggattgtt
    10921 ctaaaacttc tttgttcaac tgacggaaat gatcggtata aataggagca ccatccacac
    10981 ctaaatagag taactcgtgc gcgagactct gtaattgttc aatttgagaa gtgagtgtat
    11041 tcataactta aatgacacgt aaataacttt taggaacttt gacgctggcg ctcaatacac
    11101 cggcaatacg aataacaaca taagttttgt tggcctcgct ggcaagttcg ccctcgacac
    11161 cacagaaatc acctttaact acctgaaccc tgctaccgac agataaatgg tcattatcga
    11221 aactgacgcc attcggatct aaatccatga caaatatgaa gtcctgcatc tgtttatcag
    11281 gaactatcag catagccctg gtaagcaggt ctttcatata aaaaagctgg atattgtatt
    11341 tattagaaat atcacaagca tcttgcttgg tagcttggat gaagataaga ttcttaataa
    11401 cagggacttc cacccgtttt cgacgatatt tcaactgccg gatgacaaac tgagtgggaa
    11461 gatagtaatt gagatcaagt tcagtcttca atttttcaag agagtcacga atagcaaact
    11521 cttgtttatc tcgggtacgg gcggcaaacc aatacttctg ttgttcagac atttacgatt
    11581 tatacttggg gaaattttcc tttgtttcgg gtgcgcttcg cggtttgaac gagacatctt
    11641 ttctctttca aaccgtcaaa ttttacgaaa catttttaga agttgagaac gaacgaatgt
    11701 gtttcaaaaa acgttcgtct tttgaaacag cattttttga gtttttttcg atgaaaaaat
    11761 gaatattgta aagttgctga gcagagaact ttttttgctc tatatgtgtt tgaaaatcaa
    11821 caatataaaa tctttgataa aattttatcc actaaatatt ttgtacatta aaacagactc
    11881 cttacctttg ttcaatcaaa cgaacgtttt ttgaaacaac acctatatct taagataaat
    11941 aactaataac aagatcctta cacttcaaga ttttcccttt aaactaaaaa aactccggta
    12001 ttcttttata tttatatttt tttatacaaa ctttgtcctt tcataaattc atttaataac
    12061 taacattatg gaagaaaaaa agtagttatc tcattgaatg ataacttagt aaccatcgaa
    12121 gtaaatggaa aagtaatctt tgcgggtaaa gccgacttgc aattcagcct caatcaaaag
    12181 gttagagaac cactacgcat cacaaaaggc aaaggaaagc taatggaggc acttaccgaa
    12241 agctttatca aaggcggaat caacagcatg gaaaacagac ccattgaaga actacaggaa
    12301 acaataaaag aatatctcac ctttgaatat cagcgcaaag gcattgctac agagcccaat
    12361 aaacgttctt ttctatcaga gctgaaaaaa tatgccagag cattccggaa aaagcgagat
    12421 gaaagcgaat aaccgattgt taaaatcctg taaaagcccc tttctaaagt acttttacag
    12481 gattagtcta ttcaaaactt attaccgtac tttgccatgg gtaaaaataa aagcccgaca
    12541 ataactcatt aataaactta aaaaaatcaa ttatgaaaaa gaacaggaaa gcagtatcga
    12601 aaaacgaaat gatgaaagga aaatggaaaa gacaaatcat gctcgaaaag gactacacag
    12661 aacagtgctc cgaatggatg gcagaacgac tggaagccct catagaatat atgcaatatg
    12721 gacatgcagc cgtagcttat atgaaacagg acggaacatt caaactggtg aaaggaacat
    12781 tggtgggata cgaaaaagat ttcggaaagc agtatgatcc gatggaaata aaaaacacag
    12841 tggtctaccg ggatgtggag caacaaaggt ggatgacctt caaaatagag aatttcatgg
    12901 aatggagagc gatcgtatag gagaatcttt cagtgaccaa ttaatcagta acataacaac
    12961 ttaacaatta tggcaacaac atacgatgga ataaattact ttccgatagc tgtgaatttt
    13021 atggaagaga acgcaatgga ggtaatagaa gcaaaatatg gcatgaaagg actcgcgatt
    13081 gtactgaaac tcctatgcaa aatatataaa gaaggatatt atattccgtg gggtgaggaa
    13141 caatgcctta ttttcgccaa caagacggga aaagaggcag acgcagaaga ggtgcagggg
    13201 attatcgaga taatgatcga gaaaggaatg atagacaggg gaagctatgc ggaacataaa
    13261 gtactgacct ctgaagcaat acaaaaagta tggatagagg caaccaagcg aagaaagagg
    13321 aactggacag ccatgcctta tctactgata aaaccgaaag agacatgtaa tgaagaaaag
    13381 accgtctgca cgcaaaatgt agagcaggat gcaggctctg atgcaaaaaa tgcatgcaat
    13441 accgaacaaa gtaaagtaaa gcaaagtaga gaatttcccc cctcagctcc cccaaggggg
    13501 aaggaagagg aagtcaatgc tacgccggtc agtatgcccg gatacgcatt taatacaatg
    13561 acacacaact acgtgggatt aatgggaaac ctggaacgat tcggaataac agacgaaaaa
    13621 gagatcgaag caatcctgcg actgtcagat tacgggagaa aaggaacccc tgtatggaaa
    13681 ctgatttgca gcacgaactg gagtaacatc ggagcaaaag gaaaatacat gatcgcagcg
    13741 ttgaaccggg caaagaaaag aagcggaacc taaaaaagaa tttttctgac aaacagtaca
    13801 ttttatattc tggaaaatgc tatttgcttg caatcaatta aagaacgcag ctgttttcct
    13861 ccggaaacgg gcactgattc tcaagggatt gaaaagcgat tcaaaaagca ctaatacgaa
    13921 gttaaaatcg tgacttcagg aagttaactt cccgaagata cgattttaac ttcgtaaaat
    13981 tatgatatta acttcgtaaa caacaagatg ttaacttcgt aaacggcatc atccggacat
    14041 caaagcaatc aaaaaagatt gtcagactat agtatttcag gcagttgcca gacttgtatg
    14101 tgacgaatcc cttctttgga gggcaatgtg gtatcgtcca tagaaacgac ccacttttca
    14161 taattgtctt gtatcatctc cagcgtgttg tacatttgct ccacttgaaa atcatcattg
    14221 agcagaggtg cacattgcaa atacacaatg cggtctttct tcctg
//
