LOCUS       c00018_gnlPro..        24639 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DFLJLCLK_18.
ACCESSION   c00018_gnlPro..
VERSION     c00018_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 18:12:06
            Original ID  :: gnl|Prokka|DFLJLCLK_18
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 423167
            Orig. end    :: 447806
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..24639
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[433167:437806]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14639
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..24639
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..24639
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             238..1752
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 270.1; E-value:
                     8.9e-83)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_354"
                     /sec_met_domain="AMP-binding (E-value: 6.7e-82, bitscore:
                     270.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTSSQKDIINDILSAMQCYPENEAFIIDDKHYTYAQLGEITASI
                     THSLSEIKDEKIGIVAENRIETYAAILAVLAGGKTYVILHPAYPEERNLKIAALAGLRT
                     LLCTSDTDRSAFGTGHFRIIDTDRLPGKAQSEQQSHSSDEERNAYIIFTSGSTGEPKGV
                     PITRANLNAFYRAYSSLDWNLDEHDRMLQMFELTFDVSVVSLLYPLTLGAAVYTVGHQD
                     VKHFKVFELLEKYQLTFATVTPSLLQLLSPYFDEINLPSLKYLGVSAEASQTELLERFR
                     KSAPNATFINLYGPTEATIYCTCYRIPASDKCKHYNGMVAIGKPFPGIRAIIADEEGNE
                     LPQGETGELWVSGRQVMKGYLDDPEKSALVLIHRPDGQIYYRTGDLCILDGDGDIIYCG
                     RKDYQVKIQGFRIELSEIEYTAQSFFKTPCSVAAVPLLCDGICNELHLAVETTECTQSA
                     LIEYLKEKLPKYMLPKQIHCISQFPVTNSNKTDRKKIAELIKEKKL"
     CDS             1767..2009
                     /locus_tag="ctg18_355"
                     /transl_table=11
                     /translation="MNREEVLKQLQSIFRDILKKDNVCIDESSTSKDVDGWDSLTHMQI
                     IAQIEKHFGVRFNFREVIKFKNVGDLCSALLTKME"
     CDS             2013..3395
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MBOAT"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_356"
                     /sec_met_domain="MBOAT (E-value: 4.1e-21, bitscore: 70.5,
                     seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQFLSFSFLALFTLCFFLYYAVKGRARNLILLVTSCIFIGWYYLP
                     FLLTAVVVALFTFFWAQWMESRAKAGKKTKPVYIAGIIALIGGWLLLHGTVIDDIIFPL
                     GMSFYTFQAISYLTDVYWQEQRSERNWVDFLIYMLFFMKFLSGPIERGGDLLPQLKDPR
                     PFIYSNAVTGLKYILLGLIKKLLIANQISPQTDVMFHSIHDLSGVQLLMTCLLYPIELY
                     ADFSGYTDIAIGGAYMFGIKLSPNFNRPFAARSTADFWRRWHMSLSFWVRDYLYVPLTA
                     GTRNWGQWGIYFSLLITFLALGLWHGAGLTFAIYGLIQGVLICWEMKTAAFRNNLPQYI
                     GKYAADSLLIVRTYLLFALSLIFFRVQSLSDAWYFLRNISFEVHSSWKEMNIGIRDHNC
                     IVAGSALLLVLIYEYYASKYNLMETLERQPAWLRWSVYYLLVFALLMLGKFDTETFIYL
                     QF"
     CDS             3414..4454
                     /locus_tag="ctg18_357"
                     /transl_table=11
                     /translation="MLHHSSRISPKTRFCLKLLLLILPLIPIVVVYFMFDPYRVLHPYK
                     RFDDSPMLLNEAHVGWQNYLQNRDSIAYNSFILGNSCTMAFLTGEWEKYLDKNDHAVRF
                     YDNGESLGGVRQKLQLLDSVGAPLKNVLIVLDKKSLDKNAPLSGNNHLFSAEAAGISQL
                     GFQLRFLQEFLYPDRMIPYIDYLIRHKYAPYMKGVINPGDPVREPYTNNFINPREKEIA
                     QDGEIYWSRHEKEFKKRTNAGMEELPVIFASQIQVLRSIKKICDKHHTNLKFIIGPDYY
                     QKKTSREDIKILKAILGDSAVWDFTGINEYTADIHHYYEPGHYRPLLGARLLKAIYQDQ
                     DTCHRQ"
     CDS             4559..4951
                     /locus_tag="ctg18_358"
                     /transl_table=11
                     /translation="MKKILLLLSVCISFSSCCTLFSSSKQDITFTGMNGTKIYEASTKQ
                     KIAEIKEDNSVTVQIKKKREDKQLVAKKEGYQTTPFVLESTFNNACLWNILFWPGFLVD
                     LGTQKMNKWDNTIINIEMEKENTENK"
     CDS             complement(5144..5773)
                     /locus_tag="ctg18_359"
                     /transl_table=11
                     /translation="MLSDGDFQYIPYLFISMLANLDRYKIVLASNSPRRKELMTGLGVD
                     YVVKTLPDVDESYPDTLQGEEIPLFIAREKAAAYQSMIGPEELLITADTIVWHEGKALG
                     KPVGRQDAIEMLRSLSGKSHQVITGVCVTTREWQKCFAAVTDVRFAILDEDEIAYYVDH
                     YQPMDKAGSYGVQEWIGFVGVESISGSYFNVMGLPIQKLYRELKQL"
     CDS             complement(5757..6278)
                     /locus_tag="ctg18_360"
                     /transl_table=11
                     /translation="MSTINYDLTRIKALAFDVDGVLSANVIPLHPSGEPMRTVNVKDGY
                     AIQLAVKKGLRIAIITGGRSDVVRKRFIGLGVSDLYFGSAVKIHDYRGFRDKHGLTDEE
                     ILYMGDDVPDMEVMRECGLPCCPKDAVPEVKAIARYISYADGGYGCGRDVVEQVLKAQG
                     QWLSDDAFGW"
     CDS             complement(6299..7090)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_361"
                     /sec_met_domain="F420_oxidored (E-value: 7.5e-13, bitscore:
                     43.8, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRSIEDTPIVFIGAGNLATNLAKALYRKGFRIVQVYSRTEESAR
                     ELAQKVEAEYTTDLAEVNPYAKLYIVSLKDSAFAELLQGIVEGKREEALMVHTAGSIPM
                     NVWEGHVPHYGVFYPMQTFSKQREVDFKEIPFFIEASSAEDAAFLKAIASTLSNRVYDA
                     DSEQRKSLHLAAVFTCNFTNHMYALAAELLKKYNLPFDVMLPLIDETARKVHELEPKTA
                     QTGPAIRYDENVIGNHLRMLADDPAMQRLYELLSRSIHERQ"
     CDS             complement(7087..7419)
                     /locus_tag="ctg18_362"
                     /transl_table=11
                     /translation="VSAVKANNKDTYKATAVTLIVMGVLYLIDKLIHFSTLGIPWVMNK
                     DNLLLYTAVIFLFIKRDKSVGLVLLGLWLVLNIGLIVSLLGSMSGYLLPLALLIIGGIL
                     YLISTR"
     CDS             complement(7422..7919)
                     /locus_tag="ctg18_363"
                     /transl_table=11
                     /translation="MRKFTGEELSQEDVVALLKAALMAPTSKRSNSWQFIAVDDKKLLS
                     ELSHCKEQASAFIADAALAIVVTADPLASNVWIEDASIASIMIQLQAEDLGLGSCWVQV
                     RERYTATGMPSDEFVRGVLDIPLQLQVLSVIAIGHKGMERKPFNEDHLQWEKIHINKFG
                     GK"
     CDS             complement(8125..8667)
                     /locus_tag="ctg18_364"
                     /transl_table=11
                     /translation="MLEEILEFNKKFVENRGYEKYITNKYPDKKIAILSCMDTRLTELL
                     PAALGIHNGDVKIIKNAGAVISHPFGSVIRSLLVAIIELGVEEVMVIAHSDCGACHMNS
                     DEMIAHMKKRGIKSETIDMIRYCGVDFNSWLGGFDDPVKSVRGTVRSIENHPLIPKDVR
                     VHGFIIDSLTGELTRVE"
     CDS             8785..9768
                     /locus_tag="ctg18_365"
                     /transl_table=11
                     /translation="MPLKLTTYYQGSEIPDFPGTNTFHSKELFQIYEETPGYTPLLIMA
                     SEDGKPVARLLAAIRKSIRMFPPAFIKRCEIYGTGEYLIAEADKERIFGEMLEHLTTEA
                     LRNSFLIEFRNLENAMFGYKYFRSNRYFPVNWLRVRNSLHGIENAEQRFSPSRIRQIKK
                     GLKNGAKVDEARTVEEIREFSNMLRHLYSSRIRKHFPNIIFFQHMDTRLIHSRQAKIFI
                     VRYKDKIIGGSACIYSGNDAYLWFSGGMRKTYALQYPGILAVWKALQDAHQNGFRHMEF
                     MDAGLPFKKHGYRDFVLRFGGKQSSTRRWFRFRWQWLNDLLIKIYV"
     CDS             10001..10405
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_366"
                     /sec_met_domain="Glyoxalase_4 (E-value: 1e-22, bitscore:
                     75.4, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGDTKIELLEPTCPESTIAKFIENKGAGVHHVAFAIEDGVANALAEAESKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             10531..12084
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_367"
                     /sec_met_domain="CT_Btheta (E-value: 9.5e-290, bitscore:
                     955.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKVKELIELRAQARLGGGEKAIEKQHAKGKYTARERIAQL
                     LDEGSFEELDMFVQHRCTNFGQEKKHFLGDGVVTGYGTIEGRLVYVFAQDFTVFGGSLS
                     ETMAQKICKVMDMAMKMGAPVIGINDSGGARIQEGINALSGYAEIFQRNIMASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMTEGTSYMFLTGPAVVKTVTGEDVSQEDLGGASVHAS
                     KSGVTHFTAETGEEGLAIIRKLLSFIPQNNLEEAPLVNCTDPIDRMDDLLNEIIPDSPN
                     KPYDMYEVIGAIIDNGEFLEVQKDYAKNLIIGFARMNGQSVGVVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPLVTLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTV
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVAVLYAKEAKDQENPAQFLA
                     DKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLTNPAKKHGNIPL
                     "
     CDS             12105..13019
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_368"
                     /sec_met_domain="OAD_gamma (E-value: 5.9e-15, bitscore:
                     50.6, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKRIGIFIALLAMVCMGLRAQSATSLRINEVLVVNDQNYQDDY
                     GLHNAWIEIFNTSFASVNLEGCFLTNDKNNPTKYPIPKGDVLTLIKPRQHALFWADGMP
                     NRGTFHVNFTLDPNKENYIALYDSNGKTLIDEVTIPAGQLADRSYAREKDGSANWVVKG
                     EGEHSYVTPSTNNMTIDKNPKIENFKKHDSIGIGMAIIAMSVVFIGLVLLYLSFKAVGN
                     VAVRLGKKNAMKATGITDKTEAKEKNLGSHTGEETAAIAMALHEYLNDAHDVEDMILTI
                     NKVKRTYSPWSSKIYTLRQTPKR"
     CDS             13045..13476
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 69.7; E-value:
                     4.8e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_369"
                     /sec_met_domain="Biotin_lipoyl (E-value: 3.7e-21, bitscore:
                     69.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQYKYKINGNLYNVTVNDVEDNIANVEVNGTSYKVELDKPVKAA
                     PKPVTRPAAAPKTETGAPVVTKQPTASKKDGVKSPLPGVILDIKVKEGDTVKRGQTIII
                     LEAMKMENNINANKDGKVAEIKVNKGDSVLEGTDLVIIE"
     CDS             13479..14639
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_370"
                     /sec_met_domain="OAD_beta (E-value: 1.8e-152, bitscore:
                     502.1, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFVSFLGNNLVDFWGYTGFANATPGHLFMLLIGLFFIYLAVAK
                     EFEPMLLIPIGFGILIGNIPFNMEAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYIIALLIGFEPNQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRALTTKHERLIRMKPPRIVSHTEKVIFP
                     IVGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDVITILLGLTVGAS
                     TQASQFLTWDSILIFILGAFSFIIATASGVMFVKFFNLFLKKGNKINPLIGNAGVSAVP
                     DSARISQVIGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             14788..16119
                     /locus_tag="ctg18_371"
                     /transl_table=11
                     /translation="MRTRTMKPLFLIFCLCLSPLLMGQNQNKIQEAMANYDYETAVELI
                     NKEPPTIPLLMQKAKALKGIGSNTEALRSIRQVIAEDSTNQQAHIEAAECCKAMAKYND
                     ALDYYRKAISLNPKNKYARLQFINLLCNTKNYAEAFGESSMMSETDSSAVVLHLQAQSL
                     EGMQQILPAIGCYEVIQDKYPDDYLAAAKLGNLNIVAGYPEYAIQATERYRERDSTNLI
                     VNQQNALAYCHAEQYPTAIKRYEKLCQQGDSSTQTLYYLGVSYYADEYYYEAHACFSKL
                     QKEMEENPNLLYYLGRCCAKTSWKKEGIEHLEKAIELTIPKDSTMIRLYKGLVDCCKLA
                     QDTPKQIQALRELYKYDKTNHKLLYDIAWNYSYQLKDNKSAERYLQAFLKTRKANARKE
                     EPVSEKGELVLGLENYYNAAENWLKDLQKEKFFKEGIPLESQKQ"
     CDS             16134..17426
                     /locus_tag="ctg18_372"
                     /transl_table=11
                     /translation="MKHWILLLYLGFSVVLRAQNTASVQEAMANYDYKTVIRLIDEESA
                     SPQLLIQKAKALKSLGRTAEALSTLQHIIIELPENQQALVEAAECCRQLSKFNEALGYY
                     RKVMELNPEHIYAHLQYTRLLYNYQRYGDALRESIALARKDSSATVLRLMAESMEGAGM
                     PVESMFCYLSIIRKYPSDYLSVAKLGSIFNTMKDYEGAIALTEAYRRTDSTNVEVNRQN
                     ALAYCLRKEYPTAIKRYQDLTARGDSTLLTCYYLGVSYYATKEYYKARDWLLKAKSCQS
                     PGANLLYYLGRSCSKTLWKQEGIGYLNQAIALTIPADSIMERLYSGLADCYRQTKQTRD
                     QIKATKEQYKYAPDKHILLYNLAFLSDKIGDTKATEHYLQAFLRTKSKQNAVLQQPDDD
                     EEEPAPYIDYYKSATNKLESIRKEKFLKGEK"
     CDS             17930..19780
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_373"
                     /sec_met_domain="Alpha-amylase (E-value: 9.6e-62, bitscore:
                     204.3, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLLLLLGSFLLSLTTYAAMNISKIDPPFWFTGMNNPELQLMVY
                     GEGIGQASVSVNYPGVSLSSVVKLESNNYLLVYLHLDKEVKPGKMPITFTVGKKKLVKE
                     YELKARSKAGVDHKGFDASDALYLLMPDRFANGNPDNDRIEGMAEYKVDRNDPNARHGG
                     DLAGIEQNLDYFTDLGVTALWFTPVLENNMKGGSYHGYATTDYYKVDPRFGTNEEYRSL
                     IAKAHNRDIKVVMDMIFNHCGVEHPWIKDMPSKDWFNHADFKNNFVQTSYKLTPHVDPY
                     ASEYDFDQMNNGWFVEAMPDLNQKNPHVYKYLLQNSLWWIEYADIDGIRMDTYPYADYD
                     AMSNWMKELNEEYPNYNTVGETWVTEPAYTAWWQKDSKLSAPRNSHLKTVMDFSFFDKV
                     NTAKNEQTDTWFKGLDRVYNNFVYDYLYPNPASVLAFIENHDTDRFLGEGENLDMLKQA
                     STLLLTTRRIPQLYYGTEVMMNGVKSKSDGYVRKDFPGGWTDDKENALTPEGRTRLQNE
                     SYNFYRNLLNWRKGNDVIAKGSMKQFMVQHGVYAYARQYKGKTVFVLLNGTDKEVKLPL
                     KYYAEVLKDKTQGKDVISGKVTALNEELTMAPRQSMVIEL"
     CDS             19938..20378
                     /locus_tag="ctg18_374"
                     /transl_table=11
                     /translation="MTNNESERELVLQTLRTWMAFRQAVQRVLKRHNVDMTFEMLQVMN
                     CLWNKQGISQQSLAEKTAKDKACLTNLINNLEKKNWVIRKEGPSDRRNRLIFLTPQGEE
                     LALTVKPLINDIYAQTGTEMEASRITECIEDLKRLHEVLNEI"
     CDS             20391..21458
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Biotin_lipoyl_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_375"
                     /sec_met_domain="Biotin_lipoyl_2 (E-value: 1e-10, bitscore:
                     36.2, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTHQIKLKQLRRLKFRNIFLNTVCILLALAGISWTVNYFWKYAR
                     YEITNDAVVDQYIAPLNIRIPGYIKEVRFTEHQYVHAGDTLLILDDREYRIRLKDAEAA
                     LMDALGSKEVLNSGIRTSGVNVAVQEANIAETLARLSQQEAELNRYTRLLKKQAVSQQD
                     YELAKANFEATRARYNALLRQKEAAQSQYSETSKRSTGAEANILRKEADLEMARLNLSY
                     TVVTAPYDGYTGRRTLEPGQFVQGGQTLSYLVRGNDKWVTANYKETQIAHIYIGQKVRI
                     KVDAFSGRTFHGTVTAISEATGSKYSLVPTDNSAGNFVKVQQRIPVRIDLNDASPEEME
                     CLRAGMMVETEAVRP"
     CDS             21463..23058
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_376"
                     /sec_met_domain="MFS_1 (E-value: 3e-13, bitscore: 44.2,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKLNLPTRPWVPQWLGIVTMFIVIFPITLLNGAYTGSMVEVSNT
                     LGVLSEDITMAYYSASVGMAVAYPIVPKIRTIATPKTLLLTDLLLQIFFSLVCAQTGSM
                     DVIMVCSFCMGFLKAFVMLEFIILIRPLFSPKNVRSEFYAYFYPIVFSGGQLSMAITAQ
                     LAYHYQWQHMYYFVTILLLIAILFVICFFRYARRPMHIPFKEMDGRSMFIIATAFLLTL
                     YTFTYGKTLDWFASPKIRVYVFVIPLLIALFIHRQRTQGKPFVSLKPLFLHKSIIGYGF
                     MVLAMFLTATSSLVTNYMNSIIRVDSIHANSLSLWLLPGYVVGAVICFWWFRWQRWRFR
                     FLISGGMFCYVIYLAILYFGITPYGTYEMLYLPILFRGVGMMVIFIAFGVFVVEDLDPR
                     LTLSNAFFLISFRSVLAPVLSASFFNNMLYYLQAKGMNILSENMTLTNPLAEQKYNQAL
                     SNALAQGHEFGEAGQLAANSLYSTLQQQSLLLALKTLIGYVLILALVIAVIAAFIPFHK
                     TLKVAVVKTGDDMV"
     CDS             complement(23153..24157)
                     /locus_tag="ctg18_377"
                     /transl_table=11
                     /translation="MVNYKDLGLVNTRDMFAKAIKGGYAIPAFNFNNMEQMQAIIKAAV
                     ETKSPVILQVSKGARQYANATLLRYMAQGAVEYAKELGCKNPEIVLHLDHGDTFETCKS
                     CIDSGFSSVMIDGSHLPYDENVALTKKVVEYAHQFDVTVEGELGVLAGVEDEVSSDHHT
                     YTEPDEVVDFVTKTGCDSLAISIGTSHGAYKFTPEQCHIDPKTGRMVPPPLAFDVLDGV
                     MKELPGFPIVLHGSSSVPEEEVATINQFGGALKAAIGIPEEELRKAAKSAVCKINIDSD
                     SRLAMTAAIRKVFAEKPAEFDPRKYLGPARDNMEKLYKHKIINVLGSDNKLAE"
ORIGIN
        1 gtatcaataa agtatcgtgt tgtctatccc attcaaagtc gtcggctatg aagccaacgc
       61 tatttcccct tccgaaagag ggaaagcgag accgggcacg tgcgtaccac acaattaaca
      121 ttctttaatc gattgtgcgt agggagatca gaccatttca ctgtcatctt aataaacgat
      181 ctcaagaaga tatataaaga acccctaaac ccaaaacatg aataaaaact aatggatatg
      241 acaacatctt cccagaagga tattatcaat gatattcttt ccgccatgca atgttatccc
      301 gaaaacgaag cattcattat tgacgataaa cattatactt atgcccaact cggtgaaata
      361 acagcttcta tcacccattc gctatcagaa ataaaagatg aaaaaatcgg aatcgtagcg
      421 gaaaaccgga ttgaaaccta tgctgctatt ctggcagtac tagccggcgg aaagacctat
      481 gttatcctgc atcctgccta cccggaagag cgtaatctca aaatagccgc tctggccgga
      541 ctgcgtactt tgctctgtac aagtgacact gaccggtcag cattcggcac cggacacttc
      601 agaatcatcg atacggaccg gctaccggga aaagcacagt cagaacaaca gtctcattca
      661 tcggacgaag aaaggaacgc ttatatcatt tttacatcgg gaagcacagg cgagcccaaa
      721 ggagtgccca tcacacgggc taacttgaac gccttttacc gggcatacag ttcgctcgac
      781 tggaatctgg atgaacatga tcgcatgttg caaatgttcg aacttacatt cgatgtatcc
      841 gtagtatcct tactgtatcc tcttacttta ggtgctgccg tttatacggt aggccatcag
      901 gatgtaaagc acttcaaggt gtttgaactt ctggagaagt atcaactgac ctttgccact
      961 gtcactccct cactgctaca actcctttca ccctacttcg acgaaatcaa tctgccctct
     1021 ctgaaatatc tgggagtatc ggcagaagca tcgcaaaccg agctgttgga gcgattcaga
     1081 aaatcggcac ccaacgcaac gttcatcaac ctatacggac cgaccgaggc tacgatttac
     1141 tgcacctgtt accgtattcc ggcttcggac aaatgcaagc attacaacgg aatggtggct
     1201 atcggaaaac catttcccgg catccgcgcc atcattgccg acgaagaagg aaacgagcta
     1261 cctcaaggag agacgggaga actttgggta tccggccggc aggtaatgaa aggttatctg
     1321 gacgacccgg aaaaatcggc attggttctg atacaccgtc ccgacggaca aatctattac
     1381 cggaccggag acttgtgtat tctggatggc gacggggata ttatttattg cggacgtaaa
     1441 gactatcagg tgaaaataca gggtttcagg atagaactga gtgaaataga atatactgcc
     1501 cagtcgtttt tcaagactcc ctgcagcgtg gctgccgttc cgttgctctg cgacggaatc
     1561 tgtaacgaat tacatctggc cgtcgagaca actgaatgta cccaaagcgc attgatagaa
     1621 tatctgaaag aaaagctgcc caaatacatg ctgccgaagc agattcattg tatttcccaa
     1681 tttccggtga ccaatagtaa taaaacagac cgtaaaaaga ttgccgaact gataaaagag
     1741 aagaaactct aaaaacaata ataaatatga atcgagaaga agtattaaaa caactacaaa
     1801 gcattttccg tgatatctta aaaaaggaca acgtatgtat cgacgaatca tctacctcaa
     1861 aagatgtaga tggctgggac tcgctaaccc acatgcaaat tatagctcaa atcgagaaac
     1921 atttcggagt acgtttcaat ttcagggagg tcattaagtt caagaatgtc ggcgatttgt
     1981 gcagtgcctt attaaccaaa atggaataaa cgatgcagtt cctctctttt agtttcctgg
     2041 ccctgtttac cctctgtttc ttcctctact atgcagtcaa aggccgtgcc cgcaacctca
     2101 tactactggt aaccagttgt attttcatcg gatggtacta tctgcctttc ctgttgacgg
     2161 cagtagtggt agcactgttc accttctttt gggcacaatg gatggaaagc agggcaaaag
     2221 ccggaaaaaa gaccaaaccc gtctatatcg caggaatcat cgccctgatc ggcggatggc
     2281 tccttcttca tggcacggtc atagatgata tcatctttcc acttgggatg tcattttaca
     2341 catttcaagc catcagttat ctgacagacg tgtactggca agagcaacgc agcgaaagaa
     2401 actgggtgga tttcctgatc tatatgcttt tcttcatgaa gtttctctcc ggccctatcg
     2461 aacggggtgg agacctgttg ccacaattga aagatccccg cccgttcatc tactcaaacg
     2521 cggtgaccgg actgaaatat attttactcg gactgatcaa gaaactgctg atagccaatc
     2581 agatctcccc acaaacagat gtcatgtttc attcgattca tgacctctcg ggtgtacaac
     2641 tgctaatgac ttgcctactc taccctatcg aactgtatgc cgatttttcg ggttatacgg
     2701 atattgctat cggaggggcc tatatgttcg gcatcaagtt gtcgcccaac ttcaaccgcc
     2761 cgtttgcagc acgctcgact gccgacttct ggcgccgttg gcacatgtca ctctccttct
     2821 gggtacgcga ttatctctat gtaccgctaa ccgccggtac ccgtaactgg ggacagtggg
     2881 gaatctactt cagcctcctc atcacctttc tcgcattggg tttgtggcat ggggccggat
     2941 tgactttcgc catatacggc ctgattcagg gtgtccttat ctgctgggaa atgaaaacag
     3001 ctgctttccg caataatctg ccccaatata taggaaaata tgcggccgac agcttgctga
     3061 ttgtccggac ttatctattg ttcgcactct cgcttatatt ctttcgtgta caatcgctga
     3121 gcgatgcctg gtatttctta cggaacatct cgttcgaggt acattcttcc tggaaagaaa
     3181 tgaacatcgg catacgcgat cataattgca tcgtagcagg ttcggcccta ttactagtat
     3241 taatctacga atattatgca tctaagtaca acctgatgga aacacttgaa cgccaacccg
     3301 catggttacg gtggagtgtc tactatctgt tggtattcgc tctgctgatg ttaggcaaat
     3361 ttgacacgga aactttcatc tatttacaat tttaaccgaa accctttacg cgcatgctac
     3421 atcattcatc gagaatctcc cccaagacac gtttttgcct gaagttgctt ttactgatcc
     3481 tgccgctgat cccgatagtg gttgtctatt ttatgtttga tccttatagg gtattacacc
     3541 cctacaaacg attcgacgac tctcccatgc tactcaacga agcccatgtg ggatggcaga
     3601 attatctgca gaatcgcgat tcgatagcct ataactcctt tatactcggc aactcctgta
     3661 ccatggcatt cctgacagga gaatgggaaa aatacctgga taagaacgac catgccgtac
     3721 gcttctatga caacggagaa agcctgggcg gcgtccgtca aaagcttcag ctgctcgact
     3781 ctgtaggtgc acccctgaaa aatgtactga tcgttctgga taaaaaatca ctggacaaaa
     3841 acgctccttt atcgggcaac aatcatctgt tttcggccga agcagccggc atcagccaat
     3901 tgggattcca gttgagattc ctgcaggagt tcctttatcc ggacagaatg attccttaca
     3961 tagattatct gatccgacat aagtatgctc cttatatgaa aggggttata aatccgggag
     4021 atcccgtcag ggagccttac acgaacaatt ttatcaatcc cagagaaaaa gagatcgcgc
     4081 aagatggcga aatatactgg agccgtcatg aaaaagaatt caagaagcga acgaatgcgg
     4141 gtatggaaga acttcctgtt atatttgcca gccagattca ggtacttcgc tccatcaaaa
     4201 aaatctgcga taagcaccac acgaacctga agttcatcat cggtccggat tactatcaga
     4261 aaaagaccag ccgggaagac ataaaaatat tgaaggctat actgggtgat tccgctgtct
     4321 gggatttcac gggaatcaac gaatacacag ccgacataca tcattattac gaacccggtc
     4381 attatcgtcc gctgctggga gcacgcttac tgaaagccat ttatcaggat caagacacct
     4441 gccacaggca ataaaagttc ctcccataac agtagcacac acagaagaag agcatcctcg
     4501 atccgaaaga aataattaga tcaaagaaaa caattatatc acattaaaaa cttagattat
     4561 gaaaaagatt ttattattgc tatccgtctg tatttcattt tcatcatgct gtacattatt
     4621 cagcagttcc aaacaagata tcacctttac gggaatgaat ggaactaaaa tctacgaagc
     4681 atcgaccaaa cagaaaatag cggaaatcaa agaagacaat agtgtcactg tacaaatcaa
     4741 aaagaaaagg gaagacaaac aactagtagc caaaaaggaa gggtaccaaa cgactccctt
     4801 tgtcctggaa tctacattta acaatgcctg cctgtggaac attctatttt ggccgggctt
     4861 tctggtagat ttgggtacgc aaaagatgaa caaatgggat aacacaatta tcaatatcga
     4921 aatggagaaa gaaaatacag aaaacaaatg atcaaactat aatttcgcat ggcactcttc
     4981 tccttccacg gagggagtcg ccatacggaa tcatgcgacc tacaaggaag gcataattca
     5041 ccacaaggca acacagagtt ttttataaaa gttctttaga gaataaatct actctgtgag
     5101 actctgtgct actccgttgt atatacgagt ttcggcacac tctctatagt tgtttcaatt
     5161 ctctgtataa tttctgaatg ggaagtccca ttacattgaa gtagctgccg gatatggatt
     5221 ctactccgac aaaaccgatc cactcctgca caccatacga accggctttg tccatgggct
     5281 gatagtgatc gacataataa gcgatttcat cttcatcaag aatcgcaaaa cggacatccg
     5341 tcacggcagc gaaacatttt tgccattctc gggtagtgac acacacaccg gtaatcactt
     5401 ggtgcgattt accggagagg ctccgcaaca tctctatggc atcctgcctt ccgacaggtt
     5461 tgccgagcgc tttgccttca tgccagacaa tggtatcggc tgtgatcaaa agctcttccg
     5521 gtccgatcat cgactgatag gcggctgcct tctcacgggc tatgaaaaga ggaatctctt
     5581 caccttgcaa cgtatcggga taagattcgt ccacatccgg caaagttttt actacataat
     5641 cgacacccaa gcccgtcatc agctctttcc gacgcggaga attagaggcc aatacgattt
     5701 tataacgatc taagttagca agcatactga taaataaata aggtatatac tggaaatcac
     5761 catccgaaag catcatcgga caaccattgg ccttgtgctt taagcacctg ctccaccaca
     5821 tcgcgtccac agccgtatcc tccatcggca tacgaaatgt aacgggcaat cgctttcacc
     5881 tcgggaaccg catctttggg acagcagggc aatccgcact cacgcatcac ttccatatcg
     5941 ggaacgtcat cgcccatgta gagtatctcc tcgtccgtaa gtccgtgttt gtcacggaaa
     6001 ccacgataat cgtgtatctt caccgcagag ccgaagtaca gatcggatac ccccaaccct
     6061 ataaaacgtt tccgcacgac atcgctccgc ccacctgtaa taatagcgat acgaagccct
     6121 ttttttacgg ccaattggat ggcataaccg tcttttacat ttaccgtacg catcggttca
     6181 cccgacggat gcaaagggat gacattggcg ctcagcactc cgtctacatc gaaagcaagt
     6241 gcctttatcc gggtaaggtc gtaattgatt gtgctcattt ttatttaatg tttcgggatt
     6301 attgtctttc gtgaatgctt cggctaagca actcgtataa ccgctgcatg gcaggatcat
     6361 cggcaagcat ccgcaagtga ttgccgatca cattctcgtc ataacggatg gccggcccgg
     6421 tctgggccgt cttaggttcc agttcgtgca ccttacgggc ggtttcatca atcaacggca
     6481 acatcacgtc aaacggcaga ttgtatttct taagcaactc ggcagcaagg gcatacatgt
     6541 gattggtgaa gttacatgta aacacggcag ccagatggag acttttacgc tgctccgagt
     6601 cggcatcgta cacacggttg gacagtgtag aggcaatggc tttcagaaac gcggcatctt
     6661 ctgccgaaga agcctctatg aagaaaggaa tctccttaaa atctacctcc cgctgcttgc
     6721 tgaaagtctg catgggatag aacacaccgt aatgcgggac atgtccttcc cagacattca
     6781 tcgggatgct acctgccgta tgcaccatca atgcctcttc ccgcttacct tcgacaatgc
     6841 cctgaagaag ttcggcaaag gcggaatctt tcagtgaaac aatatacagc ttcgcatacg
     6901 ggttcacctc tgcgaggtct gtcgtatatt cggcttccac tttctgtgcc agttcgcggg
     6961 ccgactcttc cgtacggcta tacacctgta cgatacgaaa acctttccga tataaggctt
     7021 ttgccagatt agtggcaaga tttccggcac cgataaatac gatcggcgta tcttctatac
     7081 ttcttttcat cgtgttgaaa tcaaatacaa tatacctccg attatcaata aagccaaagg
     7141 cagcagataa ccggacatcg aaccaagcaa cgaaacaatc aggccgatgt tcagcaccaa
     7201 ccacaatccg agcaatacca agccgacgga tttatcccgc ttaataaaca ggaaaatcac
     7261 cgcagtgtaa agcaaaagat tatccttatt catcacccag ggtatcccca aagtggaaaa
     7321 gtgtatcagt ttgtcgatca gatagagcac ccccatcaca ataagggtga ctgctgtggc
     7381 tttgtaggta tctttattgt ttgcttttac cgcactcacc gttacttacc tccgaactta
     7441 ttaatatgga ttttttccca ttgcaaatgg tcttcattaa agggtttacg ttccatccct
     7501 ttatgcccga tcgctatgac ggacaacacc tgcaactgca aaggaatgtc gagcacaccg
     7561 cgcacaaatt catcggaagg catcccggtg gcagtatatc gctcacgcac ctgcacccag
     7621 caacttccca atcccaagtc ttcggcctga agctgaatca taatagaggc aatggaagcg
     7681 tcctcaatcc atacattgct cgccaaggga tcggcagtaa cgacaatggc caatgccgcg
     7741 tcggcaataa aggccgaagc ctgctctttg caatgtgaaa gttcactgag caacttttta
     7801 tcatcgactg caataaattg ccagctgtta ctgcgctttg aagtaggagc catcagggcc
     7861 gctttcagca aagcgactac atcttcctga gaaagttctt ctccggtaaa tttccgcatg
     7921 ctgcggcgat tttttattag ttcactgaaa ttttccatgt atctatactt tgcattattt
     7981 gaatataccg ccagtcacca tagaatgcac aaacacacgc gaaccaaggt accgcccggc
     8041 atgcccgtct atataaggta tgccctgcag gactttgcat gaatcggcgc gctccgtggc
     8101 gattcgagcg caaagatagg caatttattc cactctcgtc aactcgccgg tcagtgaatc
     8161 gatgataaaa ccatgcaccc ggacatcttt cggaataagc ggatggttct ctatggaacg
     8221 aaccgtgccc ctgacggact tcaccggatc gtcgaatccg cccagccacg aattaaaatc
     8281 gaccccgcag tagcgtatca tgtcgattgt ttcggacttg attccccgct ttttcatgtg
     8341 agctatcatt tcgtcgctgt tcatgtggca agcaccgcaa tcagaatggg caatgaccat
     8401 cacttcttct actcccaact cgatgatagc caccagcaga ctacggatga cactgccgaa
     8461 aggatgggaa atgacggcac cggcattctt tataatcttt acgtctccgt tgtgaatccc
     8521 caaagcggcg ggcaacagtt ctgtcaggcg ggtatccata caggaaagga tggcgatttt
     8581 cttatcagga tacttgttag tgatatactt ttcgtatccc ctgttctcaa cgaacttttt
     8641 gttgaattca agaatttctt ctaacataat caaaaacgga ttttattgta gtatctccac
     8701 aaagatagtc acaaaacgac agctcaacaa aataagccct gcaaatgttg taaagagaaa
     8761 taaaaaatgt aaatttgtcc cgatatgcca ttaaaactga ctacatatta ccaaggaagt
     8821 gagattccgg attttcccgg aaccaatacg tttcattcga aagagctatt tcagatctac
     8881 gaagaaactc cgggctacac cccactcctg attatggctt cggaagacgg aaaacccgtt
     8941 gcgcgactgc ttgctgccat ccgcaaaagc atccgcatgt ttcctcccgc tttcatcaaa
     9001 cgctgcgaaa tctatggcac gggcgaatat ctgatagcgg aagccgacaa ggaaaggata
     9061 ttcggcgaaa tgctggagca cctcaccacg gaggctttgc ggaactcgtt tctgatagaa
     9121 ttccgcaatc tggagaacgc catgttcggc tacaaatatt tccggtccaa cagatacttc
     9181 cctgtcaact ggctgcgggt acgaaactcg cttcacggca tcgaaaacgc cgaacagcgt
     9241 ttcagcccct cccgtatccg ccagatcaaa aaaggcctga aaaacggagc aaaagtagac
     9301 gaggcacgta cggtagaaga gatacgcgaa ttttcgaata tgctgaggca tctctattcg
     9361 tcccgcatcc gtaaacattt tcccaacatc atctttttcc aacacatgga cacccggctg
     9421 attcacagcc ggcaggcaaa gattttcatc gtccgctaca aagacaaaat tatcggaggc
     9481 tctgcctgta tctattcggg aaacgatgcc tatctctggt tttcgggagg tatgcgaaag
     9541 acctatgcct tgcaataccc gggtatactg gctgtatgga aagccctcca ggatgcccat
     9601 caaaacggat tccgccacat ggagttcatg gacgccggac tcccatttaa gaagcacggc
     9661 tatcgtgact tcgtgctccg cttcggtggc aagcaaagca gcacccggcg atggttccgt
     9721 ttccgctggc aatggctgaa cgacctgctg atcaaaatat acgtctgaac atccgcctgt
     9781 ctcagggatc agcgccaacc ctctccgcct tttaaaccac cccccttagg ttttaaacca
     9841 acgatacctg ccttttaaac ccatgcacct taggttttaa acctattttc accataatta
     9901 attgcagaaa aatttcttta ttaaacaaga attgattttc tttgtgctgt tttataccat
     9961 tccgaaaaga cgattaatac caaaattaaa aaatatagtt atgaagattt cacacattga
    10021 acatttgggc attgccgtaa aaagtatcga agaagccctt ccgtattatg aaaacgtttt
    10081 aggtttgaaa tgctacaaca tcgaaactgt agaagatcaa aaagtaagaa cagccttcct
    10141 gaaagtaggt gataccaaaa tcgaattact ggaacccaca tgtccggaaa gtaccatcgc
    10201 gaaattcatc gaaaacaaag gtgcaggtgt tcatcacgta gcattcgcca ttgaagacgg
    10261 cgtagccaat gccctggccg aagccgaaag caaagagatc cgcctgatcg acaaagctcc
    10321 gcgcaaaggt gccgaaggcc tgaacattgc tttccttcac ccgaaatcaa ctctgggcgt
    10381 actgacagaa ctctgcgaac actaaaaaga tgtacgattc ggacgatccg cgccacggat
    10441 aaacggaatt tttctttgca ttaaattccc catccgggtt gtcaatcgtc ctgttgtaaa
    10501 tattataacc ctttaaatta agaaaaactc atgagtaacc agcttgaaaa agtaaaagag
    10561 cttattgaac ttcgtgctca ggctcgttta ggtggtggcg aaaaggctat tgaaaaacaa
    10621 cacgccaaag gcaaatatac agcccgcgag cgtattgcac agttgcttga cgaaggtagt
    10681 ttcgaagaac tggatatgtt tgttcaacac agatgtacca atttcggaca agagaaaaaa
    10741 catttcctcg gcgacggtgt ggtaaccggt tatggaacga tagaaggtag attagtatat
    10801 gttttcgcac aagatttcac agtattcggt ggttcactgt cggaaaccat ggcacaaaag
    10861 atctgtaaag taatggatat ggccatgaag atgggtgccc ctgttatcgg tatcaacgac
    10921 tcgggtggcg cacgtattca ggaaggcatc aacgccctgt ccggttatgc tgaaatcttc
    10981 cagcgcaaca tcatggcttc gggtgtcatc ccacagattt caggtatttt cggtccgtgt
    11041 gccggcggtg cggtttactc tcccgccctg acggacttca cgctgatgac ggaaggtaca
    11101 tcttacatgt tcctcaccgg accggctgtt gtgaaaacag taacgggtga agacgtgtct
    11161 caggaagatc tgggtggtgc aagcgtacat gccagcaagt ccggtgtaac tcacttcact
    11221 gccgaaaccg gtgaagaagg tctggcgatt attcgcaagc ttctcagctt tattccgcaa
    11281 aacaacctgg aagaagctcc attggtgaac tgtaccgacc ccatcgaccg tatggacgac
    11341 ctgctgaacg agatcatccc cgacagcccg aacaaaccgt acgatatgta cgaagtgatc
    11401 ggcgccatca tcgataacgg agaattcctg gaagtacaga aagactatgc gaaaaatctt
    11461 attatcggtt ttgcccgtat gaacggacag tcggtaggtg tggttgccaa tcagcctaaa
    11521 tacctcgccg gagtactcga cagcaatgct tcacgcaaag gtgcacgctt cgttcgcttc
    11581 tgcgacgcat tcaacattcc gctggtgaca ttggtagacg ttccgggatt ccttccgggt
    11641 acgggtcagg aatataatgg tgtaatcctg cacggagcca agttgctgta cgcttatggt
    11701 gaagccactg tgcccaaggt aactgttacc ctgcgtaaat cttacggtgg ttcgcacatc
    11761 gtaatgagtt gcaagcaact ccgcggcgac atgaactatg catggccgac agccgaaatc
    11821 gccgtaatgg gcggtgccgg tgcagtagcg gtattgtatg ccaaagaagc caaagatcag
    11881 gaaaaccctg ctcaattcct ggcagacaag gaagccgagt acactaaact gttcgccaac
    11941 ccgtacaatg cagccaaata cggttacatt gacgacgtta tcgaaccgag aaacactcgt
    12001 ttccgcgtga tccgcgccct gcaacagctg cagaccaaaa aattaaccaa ccctgctaaa
    12061 aagcacggta atattccatt gtaacaaatt aaacatcgat tgttatgaat aagaaaagaa
    12121 tcgggatatt tatcgctctg ctggcaatgg tttgcatggg gctcagggcg caaagtgcca
    12181 ccagtctgag aatcaatgag gttttggtcg tcaacgacca gaactatcag gatgactacg
    12241 gactgcacaa tgcgtggata gagatattca acacctcttt cgcttctgta aatctggaag
    12301 gttgctttct gacgaacgat aaaaacaatc cgaccaaata tcctattccc aaaggcgacg
    12361 tgctgactct gatcaagccg cgccaacatg ctttgttctg ggcagacgga atgcctaacc
    12421 ggggtacgtt ccacgtgaac tttacgctcg acccgaacaa agagaattac attgctttgt
    12481 atgactctaa cggtaaaact ctgattgacg aagtaaccat acccgccggt cagcttgccg
    12541 accgttcata cgctcgcgaa aaagacggaa gtgccaactg ggtagtaaaa ggtgaaggag
    12601 aacacagcta tgtcactccg agcaccaaca atatgactat cgacaaaaac ccgaagatcg
    12661 agaacttcaa gaaacacgac tctatcggta tcggtatggc catcatcgcc atgtcggtcg
    12721 tattcatagg tttggtactc ttgtatcttt cattcaaggc ggtaggtaac gtagcggtca
    12781 gactgggtaa gaaaaacgcg atgaaagcca ccggtatcac cgacaagacg gaagcgaagg
    12841 aaaagaacct gggtagccac acaggtgaag aaaccgccgc aatcgccatg gctttgcatg
    12901 aatacctgaa tgacgctcac gacgttgaag acatgatttt gaccatcaac aaagtgaaac
    12961 gcacctactc accctggagt tcgaagatct acacactgcg tcagactccg aaaagataat
    13021 tactaaccct aataaaatga agcaatgaaa caatataaat ataaaatcaa cggcaacctt
    13081 tacaacgtta cagtgaacga tgtagaagat aacatagcca acgttgaagt gaacggaacc
    13141 tcttataaag tagagttgga caagcccgtc aaagccgctc caaaaccggt gacccgtccg
    13201 gcagccgctc cgaaaacgga aacaggtgct ccggtagtaa ccaaacaacc gacagcttcc
    13261 aaaaaagacg gtgtgaaatc tccgcttccg ggcgttatcc tcgacataaa agtgaaagaa
    13321 ggggataccg tgaagagagg ccagacgatc atcatccttg aggctatgaa gatggaaaac
    13381 aacatcaatg ccaataaaga cggaaaagta gcagaaatta aagttaataa aggagattct
    13441 gtacttgaag gtacagacct cgtaatcatt gaataattat gggagatttc gtatcattct
    13501 tagggaataa ccttgttgac ttctggggat acaccggttt tgcgaacgcg acacccggac
    13561 atcttttcat gttgctaatc ggtctcttct ttatctacct tgccgtagcc aaagaatttg
    13621 aaccgatgct gctgatcccc attggtttcg gtattctgat cggtaatatt ccattcaata
    13681 tggaagccgg attaaaagtg ggtatttacg aagaaggttc ggtactgaac atcctttatc
    13741 aaggagtaac ctccggctgg tatccgccgc tcattttcct gggtatcgga gccatgacgg
    13801 acttctcggc gctgatctcc aaccccaaat tgatgctgat cggagctgct gcgcaattcg
    13861 gtatcttcgg cgcgtatatc attgccctgc tcattgggtt cgaacccaac caggcgggtg
    13921 ctatcggtat cattggcggt gccgacggac cgacggccat cttcctttcg tccaaactgg
    13981 ctcccaacct gatgggtgcc atcgctgtgt cagcctattc ttacatggcg ctggtgccgg
    14041 tgatacagcc acctatcatg cgtgcgctaa ccaccaaaca cgagcgtctg atccgcatga
    14101 aaccaccgag aatagtatcg catacggaaa aagtaatctt ccccatcgtg ggtctgttgc
    14161 ttacatgctt cctggttcct tcgggtctgc ctttgctggg tatgctgttc ttcggtaatc
    14221 ttctgaaaga aagtggagta acccgtcgtt tggcaaatac ggccagtggt ccgttgatcg
    14281 atgtgatcac tatcctgttg ggactgactg tgggagcttc tacccaagct tcacaattcc
    14341 tcacctggga ttctatcttg atctttatcc tcggtgcatt ctctttcatc atcgcaacag
    14401 cgtcaggtgt catgtttgtc aaattcttca atctattctt gaagaaaggc aataagatca
    14461 atccgctgat tggtaatgca ggtgtatccg ccgtacccga ctcggcacgt atttcacagg
    14521 taatcggttt ggaatatgat ccgaccaact atctgctgat gcacgccatg ggtcctaacg
    14581 tagcgggggt tatcggttcg gctgtagctg ccggtatcct gctcggattc ctcatgtaaa
    14641 cgatattttt ttcattagta aggtagacgc ccttcttttc gcaaagaagg gcgtcttttt
    14701 tttgcgttaa tctatctaaa agacattacg aacctttcgt agaatggata tttttactaa
    14761 cttgcggaca ataaaacaat acgtcctatg agaacaagaa caatgaaacc actcttcctt
    14821 attttctgtc tttgcctcag tcccctactg atgggccaga atcaaaacaa aattcaggaa
    14881 gcaatggcaa actatgacta cgagactgcc gttgaactga taaacaagga acctcccacc
    14941 atcccactgt taatgcagaa agcaaaagcc ctgaaaggaa tcggcagcaa tacggaagct
    15001 ctacgttcca tccgccaagt gatagcggaa gactccacca accaacaggc acacatcgaa
    15061 gcagcggaat gctgtaaagc aatggccaag tacaacgatg cgctggacta ctaccggaaa
    15121 gccatcagcc tgaatcccaa aaacaagtat gcccgtttgc aattcatcaa cctgctttgc
    15181 aacaccaaaa actatgctga ggcttttgga gaaagttcaa tgatgtccga aacggacagt
    15241 tcggccgtag tgctccacct acaggctcaa agccttgaag ggatgcaaca gatactaccg
    15301 gctatcggtt gctatgaagt cattcaggat aaatatccgg acgattatct ggctgcggcc
    15361 aaactcggaa acctgaacat tgtggctgga tatcccgaat atgccatcca agctaccgaa
    15421 cgctataggg aacgggactc caccaacctg attgtcaacc agcaaaacgc tctcgcctac
    15481 tgccacgccg aacaatatcc gacagccatc aagcgctatg aaaagctgtg ccaacagggg
    15541 gacagcagta cacagacctt atactacctg ggagtcagct attacgcgga tgaatattat
    15601 tacgaagcgc acgcgtgttt cagcaaactg caaaaagaga tggaagaaaa tcccaatctg
    15661 ctctattatc tgggacgttg ctgcgccaag acttcctgga aaaaagaagg catcgaacac
    15721 ctggagaaag ctatcgaact gaccattccc aaagacagca ccatgatccg actttacaaa
    15781 ggcttggtgg attgttgtaa actggctcag gatactccaa agcaaatcca ggctctcaga
    15841 gaactgtaca aatatgacaa gacgaaccat aaacttcttt atgacatcgc ctggaactat
    15901 tcatatcaac tcaaagacaa caaatcggcc gaacgttatc tgcaggcttt cttaaaaacc
    15961 cgaaaggcga atgccaggaa agaagaaccg gtgagtgaga aaggggaact tgtactcgga
    16021 cttgaaaatt attacaacgc tgccgaaaat tggctgaaag acttacagaa agaaaagttc
    16081 ttcaaagaag gaataccgtt agaaagtcag aaacaataga atctgtcccc cccatgaaac
    16141 attggatact cctcctctat ctgggcttca gcgtagtgct gcgagctcag aacaccgcct
    16201 ccgttcaaga agcaatggca aactatgact ataaaacggt gatcagactg attgatgaag
    16261 aaagtgcatc accacagtta ctcatacaga aagccaaagc tttaaaaagt ttagggcgta
    16321 ccgccgaagc cctgtccact ttgcaacata tcattatcga gctgcccgaa aatcagcagg
    16381 cattggtaga ggctgcagaa tgttgcaggc aattgagcaa atttaacgag gccttggggt
    16441 attatcggaa ggtgatggaa ctcaatcccg aacatattta cgcacacttg caatacaccc
    16501 gcttgttata caactatcag cgatacggcg atgcattgcg tgagagtatc gcattggcca
    16561 ggaaagacag ttccgccacc gtattgcgac tgatggcgga aagcatggaa ggagccggca
    16621 tgccggtaga aagtatgttt tgctatcttt ccatcatcag gaaatatccc tccgactatc
    16681 tctcggtagc taagctgggc agtatcttca atacaatgaa agattacgaa ggggcaattg
    16741 ccctgacaga agcataccgc cggacggaca gcaccaatgt agaagtgaac cgtcaaaacg
    16801 cactggcgta ttgtctgcgc aaagaatatc ccaccgccat caaacgttat caggatctga
    16861 ccgcccgggg agacagcaca ctgctgacat gttattacct gggagtcagc tactacgcta
    16921 cgaaagaata ctataaagcg cgcgattggc tactcaaagc aaaatcatgc cagtcacccg
    16981 gcgccaacct actctactat ttgggacgtt cgtgctccaa gacattatgg aaacaagagg
    17041 gaataggata tctgaaccag gctatcgccc tgactatccc cgccgacagt atcatggagc
    17101 gcttatactc aggcttggca gactgctaca ggcaaaccaa gcaaacccgg gaccaaatca
    17161 aggctaccaa agaacaatac aaatatgccc ctgacaagca tattttactt tataacttgg
    17221 cgttcttatc ggacaaaata ggagatacta aagccacaga gcattacttg caggcttttc
    17281 tgcgaacaaa atccaaacaa aatgcagtac tacagcagcc ggatgatgac gaagaagaac
    17341 ccgcacccta catagattac tacaaaagtg ccaccaataa attggaaagc atccgaaaag
    17401 agaaattctt aaagggagaa aagtgaattg atcggataga tgcatcgttt cggacaattc
    17461 accactgagt gcagacagag tttcacagag ggagaataat ggaaaataaa tttgaagatg
    17521 tgcggtagaa ggcacagtgg cacgtaaccg aagtcacatc ggcacgcagc cgaaattacg
    17581 gtgctgtgta gctaaagtta cggtgctgcg tagccaaagt tacggtgctg cgtagccaaa
    17641 gttacggtgc tgcgtagccg aagttacggt gctgcgtaga taaagttacg gtgctgcgta
    17701 gccgaagtta cggtgctgcg tagccgaagc tatgacggca tctccttttc cggacatcac
    17761 gttcacctga ttgcatcgaa aagtgttcct catcggttga gccccatccc ggagaattct
    17821 ccaatgaaaa cgtttgcata aatagatggc acacagtaag aaagaaaacg gaaaacaatc
    17881 cgatgattta ccctatatta gcaacattaa ataataacga gctaatatca tgaaaaaatt
    17941 attgttactc ttaggttcat tcctactgtc attaaccact tatgcagcca tgaacatatc
    18001 caaaatcgat ccgcccttct ggttcaccgg tatgaacaat ccggaactcc agttaatggt
    18061 atacggtgaa ggcatcggcc aggcatccgt atcagtaaat tatcccggtg tatcgctcag
    18121 cagcgtcgtg aaactggaaa gcaacaatta cctgcttgtc tacctgcatc tcgataaaga
    18181 agtaaagccg ggcaagatgc ccatcacatt tacggtcgga aagaagaaat tggtgaaaga
    18241 gtacgaattg aaagcacgca gcaaagccgg agtcgatcac aaaggttttg acgcatcgga
    18301 tgcattatac ctgctgatgc cggaccgttt tgccaatggc aatccggata acgaccggat
    18361 agaaggcatg gccgaatata aagtggaccg caacgacccg aacgcacgtc acggaggcga
    18421 cctggccggt atcgaacaaa atctggacta ttttaccgac ttgggagtga ccgcactctg
    18481 gttcaccccg gtactcgaaa ataatatgaa aggcggctca tatcacggat atgcaacaac
    18541 cgattattac aaggtagacc cacgtttcgg cactaacgag gaatatcgct cactgatagc
    18601 gaaagcccac aaccgggaca ttaaggtcgt gatggacatg atcttcaatc attgcggagt
    18661 agaacatccc tggatcaagg acatgccttc aaaggactgg ttcaaccatg cggacttcaa
    18721 gaacaacttt gtgcaaactt cctacaagct gactccacat gtagatccgt atgcctcgga
    18781 gtacgatttc gaccagatga acaacggctg gttcgtggaa gccatgcctg acctcaacca
    18841 aaagaaccct cacgtataca aatacctctt gcagaacagc ctgtggtgga ttgagtacgc
    18901 cgatatcgac ggcatccgga tggacaccta cccgtatgcc gattacgatg ccatgagcaa
    18961 ctggatgaaa gaactgaacg aagaataccc caactacaac acggtgggcg aaacctgggt
    19021 taccgaaccg gcctatacag cctggtggca gaaagactcc aagctctccg ccccgcgcaa
    19081 cagtcacttg aaaacagtca tggatttcag cttcttcgac aaagtcaaca cggccaagaa
    19141 tgaacaaacg gacacttggt tcaaaggatt ggaccgtgtc tacaacaatt ttgtatacga
    19201 ttatctgtat cccaatccgg cttccgtact ggctttcatc gagaatcatg acaccgaccg
    19261 tttcctgggt gaaggcgaaa acctcgatat gctgaaacag gcctccaccc ttttattgac
    19321 cacccgacgc atcccgcaac tctattatgg aacggaggtg atgatgaacg gagtaaagag
    19381 taaaagcgac ggctatgtac gaaaggactt cccgggcgga tggacggacg ataaagagaa
    19441 tgccctgact cccgagggac gtacccgatt gcagaatgaa agctataact tctaccgcaa
    19501 cctgctgaac tggcgtaagg gcaacgatgt gatcgccaaa ggcagcatga aacagttcat
    19561 ggtgcagcac ggcgtatatg cttatgcacg ccaatataaa gggaaaacgg tattcgtcct
    19621 gttgaacggt acggataaag aggtgaaact tcccctgaaa tactatgccg aagtgctgaa
    19681 agacaagact caaggaaaag acgtcattag cggaaaagta acggcactca atgaagaact
    19741 gacaatggca ccccgccaat cgatggttat agagctttaa tctcacaccg gttataaccg
    19801 cataagcaaa gggcacaaag gatttcaccc gacatcctct gtgccctttg tgtagcctaa
    19861 tgcgaataat aatagtcaaa catttgacta ttatcgaaga atattcctac ctttgcagcg
    19921 actaaaagaa tacgacgatg acaaacaacg aatcggagcg cgagctcgtc ctacaaacct
    19981 tacgaacctg gatggcattc cgccaggccg ttcagcgggt actcaaacgt cacaacgtgg
    20041 atatgacctt cgagatgctg caagtaatga actgcctgtg gaacaaacaa ggcatcagcc
    20101 agcaatccct ggctgagaaa acagcaaagg acaaggcttg cctgaccaat ctgattaata
    20161 atctggaaaa gaaaaactgg gtgatacgga aagaaggccc ctccgaccgc cgaaaccgcc
    20221 tgattttcct gacgccccaa ggcgaagaac ttgccctcac cgtgaaaccc ctgatcaacg
    20281 atatctatgc ccaaaccgga acagagatgg aggcaagccg gataacggaa tgcatcgaag
    20341 atctgaagag actgcatgaa gtgctcaatg agatctaaaa gaaatccgcc atgtccaccc
    20401 atcagataaa gctaaaacaa ttgagaagac tgaagttcag gaacatcttt ctcaacacag
    20461 tatgcatcct actggcattg gcaggtattt catggacagt aaactacttc tggaaatacg
    20521 cccgctacga gataaccaat gatgccgtag tggatcaata catcgctccg ctaaacatcc
    20581 ggataccggg ctatatcaaa gaagtacgtt ttaccgaaca ccagtatgtt catgccggcg
    20641 acacgttact gatactggac gaccgggaat accggatccg gctgaaagac gcggaagcgg
    20701 ccttgatgga tgccttggga tcaaaggaag tgttaaactc cggcatccgg acttcaggag
    20761 taaatgtagc cgtacaagaa gccaacatag ccgaaacact ggcacgcctt tcacaacaag
    20821 aagcggaact gaaccgatat acccggctcc tgaaaaagca ggccgtcagc caacaggatt
    20881 atgaactggc caaagcgaac ttcgaagcga cccgggcaag atacaacgcc ctgttgcgac
    20941 aaaaagaagc ggcccaatcg cagtattccg aaaccagcaa acgcagtaca ggcgccgaag
    21001 ccaatatcct ccggaaggag gccgacctgg agatggcccg actaaacctg tcgtataccg
    21061 ttgtcaccgc accctatgac ggatacacgg gacgacgtac acttgaaccg ggacagttcg
    21121 tacaaggcgg acaaactctt tcctacctgg tacggggcaa tgacaagtgg gtgacagcca
    21181 attataaaga gactcaaata gcccatatct atatcgggca aaaagtccgc atcaaagtag
    21241 atgctttcag cggacgcact tttcacggga ccgtaaccgc catttccgaa gccaccggat
    21301 cgaaatactc cctggtaccg accgacaatt cggcagggaa cttcgtcaaa gtgcagcaac
    21361 gcattccggt ccgcatcgat ctcaatgacg cctcacccga agagatggaa tgtctccgtg
    21421 cagggatgat ggtagaaacg gaagcggtcc gcccttaggc ttatggtgaa gctcaatctg
    21481 cctacccgtc cctgggtgcc tcaatggttg ggcatcgtga ccatgtttat tgtcatcttt
    21541 cccatcaccc tgctcaacgg tgcctacaca ggaagtatgg tcgaagtatc gaacacgctg
    21601 ggagtattga gcgaagatat taccatggct tactattcag cttcggtagg gatggctgtt
    21661 gcctatccca tcgtaccgaa aatacgcacc atagccactc cgaaaacctt actgcttacc
    21721 gacctgctgc tacagatatt cttcagcctg gtatgcgccc aaaccggtag tatggatgtc
    21781 atcatggtat gcagtttctg tatgggattt ctcaaagcct tcgtcatgtt ggagttcatc
    21841 atcctgatcc gcccgctctt cagtccgaaa aacgtacgaa gtgaattcta tgcctacttc
    21901 taccccatcg ttttctccgg aggtcagcta tcgatggcta tcaccgctca actggcctat
    21961 cactaccaat ggcagcacat gtactatttt gtcaccatcc tcttgctgat cgccattctg
    22021 ttcgtcatct gtttcttccg ctatgcaagg cgtcccatgc acattccgtt caaagaaatg
    22081 gacggaagaa gcatgttcat catcgccacc gctttcctgc taacgctcta tacatttacc
    22141 tacgggaaaa cactcgattg gttcgcatcc ccgaagatca gagtatatgt attcgtcatc
    22201 ccgctcctga tagctctttt catccatcgg cagcgtacac aaggcaaacc ctttgtcagc
    22261 ctgaaaccac tctttctgca taaatccatc atcggatatg gcttcatggt actcgccatg
    22321 ttcctgacag ccaccagttc actggtaacc aactatatga acagcatcat ccgggtagac
    22381 agcatacacg ccaattcgct gagcctgtgg ctattgcccg gatatgtggt aggggccgtc
    22441 atttgcttct ggtggttccg atggcaacga tggcggtttc gcttcctcat ttcaggaggt
    22501 atgttctgct acgtcatcta tctggctatc ctctactttg gtatcacccc ttatggaact
    22561 tatgaaatgc tctacctccc catcctgttc cggggagtgg ggatgatggt catattcatt
    22621 gcgttcggtg tgtttgttgt cgaagattta gacccgcgcc tgacgttgtc caatgccttc
    22681 ttcctgattt cattccgctc agtattagct ccggtcctgt ccgcttcgtt ctttaacaac
    22741 atgctttact atctgcaggc aaaggggatg aacattcttt cggaaaacat gacgctgacc
    22801 aatccgctgg ccgaacaaaa atacaatcag gcattgagca atgccctggc gcaagggcac
    22861 gaattcggcg aggccggaca attggcagcc aacagtctgt actccacttt gcagcagcaa
    22921 tccctgttgc ttgccctgaa aaccctaatc ggctatgtac tgatactggc actggtgatt
    22981 gctgtcatcg cagcgttcat tcctttccat aaaacgctga aggtggctgt agtgaagacg
    23041 ggtgacgata tggtataatg agaagggata caaaaaagcc acccaattgc ttgagtggct
    23101 tcttaaaata taaattaaat caagtaaaac ttttaaatac tagatttgga atttattcag
    23161 ctaacttgtt gtcagaaccc agcacgttga taattttgtg cttgtagagt ttttccatat
    23221 tgtcgcgagc cggtcccaga tatttacgcg ggtcgaactc agccggtttt tctgcgaata
    23281 ccttacggat agcagcagtc atagccaggc gagagtctga gtcgatgttg attttgcaaa
    23341 cagcagactt agcggcttta cgcagttcct cttcaggaat accgatagca gctttcagtg
    23401 caccaccaaa ctggttgata gttgcaacct cttcttcagg aactgaagat gatccgtgaa
    23461 gaacgatagg gaatcccgga agttctttca ttacaccgtc caatacgtcg aatgccaacg
    23521 gaggaggaac catacggcct gtcttcggat cgatgtggca ctgttccgga gtaaatttgt
    23581 aagcaccgtg agaagtaccg atagagatag ccaatgaatc gcaacctgtc ttggtaacga
    23641 aatcaactac ttcgtccggt tcagtatatg tgtggtggtc agaagaaact tcgtcttcta
    23701 cacctgccaa tacgccaagt tcaccttcta cagttacatc gaactggtga gcgtattcaa
    23761 caactttctt agtcagagca acgttttcgt cgtaaggaag gtgagaaccg tcgatcatta
    23821 cagaagagaa gcctgagtcg atacagcttt tgcaagtttc gaaagtatct ccgtggtcga
    23881 ggtgcaaaac gatttcagga tttttgcagc cgagttcttt tgcatattct acagcaccct
    23941 gagccatgta acgcaacaat gtagcgttag catactgacg agcacctttt gatacctgca
    24001 aaataaccgg agacttagtt tctacagcag ccttgatgat agcctgcatc tgttccatat
    24061 tgttgaagtt gaatgcaggg attgcatatc cacccttgat agccttagca aacatatctc
    24121 tagtgtttac cagacctaaa tctttgtaat taaccatttt gtttaaaagt ttattgttag
    24181 tgaattaaaa attctatgca aaagtaagaa taatcctttg aatagagaaa ccctcgggcg
    24241 gaaatatccg tttgaggagc gtaattcaat tctatttcaa attatttccc atcctttaag
    24301 agctgtttgt aatgtctacg tagcaaataa aggtttttta ttgtttcctc atatatataa
    24361 tggtaggcaa atgatcgctg taaccatcca accacactct gccaccatat gtacgcaggg
    24421 gtgcaccctt atatttacca tcctgctgaa acaggtaatc gcgcatgaaa acttcattgt
    24481 gatcatattt caatcctttt gtggcttgaa gcagcgtggg cgaaaggatg atctgatcga
    24541 acagattcca tttgccgcga tagagcaaag tgcccactcc cttatcttcc agcgtcaccc
    24601 accaggggtt gtaaaggtca tcttcagtca tatcttcga
//
