LOCUS       c00052_gnlPro..        15519 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GHKMMELP_52.
ACCESSION   c00052_gnlPro..
VERSION     c00052_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 22:21:54
            Original ID  :: gnl|Prokka|GHKMMELP_52
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 100185
            Orig. end    :: 115704
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15519
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[110185:113144]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..12959
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..15519
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15519
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="2"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             451..1587
                     /locus_tag="ctg52_82"
                     /transl_table=11
                     /translation="MKRITIKQCLLACFVLPMILAGCNDADYQVIDNAIYLNEASENGS
                     AKVTVDPENVTTTTLTVRVGQPVTENVTAVLTVDPSILKEYNEANETSYEVLPEQYFTY
                     DKEIKIAAGDVSAIPSEFRVKPYSNENGELYAIPVSLTEIQGPVSTIGLSSKFIILLDK
                     PLIQSVPFMNTTNAVKPAKDELWGVTTNEWSLEAWVQMDGFDINNQAIFNSGSSDHEVY
                     IRFGDAMIPYNSLQVKTLGSQVNTVTLFEKNKWYHLAFVYNSSGLLSIYINGVLDVTLQ
                     TKGGPVRFDKMNMVSSGSYFRNNCQMAQVRLWKSAISQTQIQSNMYFAVKPADPNLIGY
                     WKMDEGKGNAFADCTGHGYDLVAGGTLVWKEHVRFDKQ"
     CDS             1610..2623
                     /locus_tag="ctg52_83"
                     /transl_table=11
                     /translation="MNRHLNFVTLICLITGFVSLASCSNDDDEMDKYQKIYIRTGVAPG
                     AEMGAAVVVDCVSNSSTADRSDFEIQLCAVQPVTRDVTAALGVDTLKVDTYNSANKTKC
                     KLLPQDNYTIETSEVVLKTGQTVADSSFQVVLKNIEKLTNPDGYVLPVALKGVTGMDEQ
                     AVSTSMKTVYIRIYTSVLYTSYTKPGNWSAVDRSAWSVSCSNVYADDDAKYGAHLAIDG
                     EINTTWFTWGVANAGECWWNTLLDRPVTLTGFSVTKQSAYGSGYNLRSAEIKVRKEGET
                     EWVTYPRVLTFRNFKGADPQYAAIEPPIPNVKEFRINCLTPDNYTGFAEINLYVKQ"
     CDS             2873..4141
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg52_84"
                     /sec_met_domain="MFS_1 (E-value: 6e-11, bitscore: 34.4,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKPISPVCWVPTVYFAMGLPFVALSMVSVLMFSDMEVSNAQIA
                     FWTSLIMLPWTLKPLWSPFLEMFKTKKYFVVATEIITGLAFALVALSLPLPDFFRYAIA
                     LMGIIALSGATHDIAGDGVYLTELTATQQAKYIGWQGAFYNLAKILANGGLVWLAGMLK
                     DEFGVVHAWMIVMLMCAGIMILIGLYHIRILPSGGGASGEVNTMSDALNMLWEVIRSFF
                     QKKHIAFYIVFIILYRFAEGYAIKIVPLFLKASVADGGLGLSTQDIGLVYGTFGAGAFI
                     LGSLLAGYYISAFGLRKTLFSLCCAFNIPFLVYFLLALYQPSDLWIIGMAIVSEYLGYG
                     FGFVGLMLFMMQQVAPGKHQMAHYAFATGIMNLGVMLPGMMSGYLSDWLGYRDFFIWVL
                     IATIPAFIVTWLVPFTYPDGKKK"
     CDS             4196..5194
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_hydro_130"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg52_85"
                     /sec_met_domain="Glyco_hydro_130 (E-value: 2.1e-69,
                     bitscore: 226.4, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEIKIAGAALPAMPWEERPAGCKDVVWRCSANPIIPRDLLPTSN
                     SIFNSAVVPFKDGYAGVFRCDDTNRRMRLHVGFSKDAVHWDINEEPLKFQCDDAEVGTW
                     VYGYDPRVCFIEDRYYVTWCNGYHGPTIGVAYTYDFVTFHQLENAFIPFNRNGVLFPRK
                     INGRFAMLSRPSDNGHTPFGDIFYSESPDMEFWGRHRHVMSPAPFEDSAWQCTKIGAGP
                     IPIETSEGWLLIYHGVLASCNGFVYSFGSALLDIDQPWKVKFRSGPYLISPQKDYECMG
                     DVPNVCFPCAALHDSETGRIAIYYGCADTVTGLAFGYIPEIIEFTKRTSII"
     CDS             complement(5320..5793)
                     /locus_tag="ctg52_86"
                     /transl_table=11
                     /translation="MKTLNYTHLEEKGANTIVLSLQQLLADFQIHYANLRGFHWNIKGH
                     GFFVLHSKFEDLYNGAAEKVDEIAERILMLGGTPANKYSDYLKMAQIKEVDGVNKADDA
                     LNHILETYGHLIAEERKILSLASSHNDEVTVAMMSDYLKEQEKMVWMLTAYNG"
     CDS             5863..6861
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     -3.5; E-value: 38)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg52_87"
                     /sec_met_domain="LysR_substrate (E-value: 1.7e-46,
                     bitscore: 150.8, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 7.1e-18, bitscore: 57.0,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRVKLKISIFALIDSISLINQRTMTIQQLEYILAVDQFRHFAKA
                     AEYCRVTQPTLSAMIQKLEDELGVKLFDRSMTPVCPTAIGKKVLEQARKILSEVICVKE
                     IISEEQHSLSGTFRLAVLPTIAPYLLPRFFPQLMEKYPDLDIRVMEMKTPDIRKALLTG
                     EADAAIIASMLDDAALTEETLFYEQFLGYVSKKEPLFKHDVIRTSDVTGERLWLLDEGH
                     CFRDQLVRFCQMEAVKISQMAYRLGSMETFMHMVESGKGITFIPELAVMQLSEEQKELV
                     RPFAIPRPTRQIVLVTRKDFIRTSLLQVLKEEIQAAVPKEMLTLQAVQCLV"
     CDS             complement(6966..7718)
                     /locus_tag="ctg52_88"
                     /transl_table=11
                     /translation="MKKFNLITFAVILMLLPILQSCLDDANNDEWVTCPPGGILAIGTM
                     KIPNADTPRDFFIALDNGDNVLPADTADIRNRKYTVAEGQRVFVGYLQMGKEKPGYENG
                     KIFTIEDILTKEIIPLTEATADSIGDDRINVTAHALTKDYLTIEYQYLGSMNENKKHML
                     NLVQNEITGPIKDDGYIYLEFRHNAFNDSPNQLGSSLVSFKLDSIAEQLATAKGIKLRV
                     NTIYDNIQYVTIDINEDKNLKIKSFHSQ"
     CDS             7906..8454
                     /locus_tag="ctg52_89"
                     /transl_table=11
                     /translation="MNELELSERCRQGDNRARKELYEQYAGRMLGVCLRYAGDRDMAQD
                     LVHDGFLKIFDSFDKFTWRGEGSLRAWMERVMVNTVLQFLRKNDVMNQTTALDEVPETY
                     EEPDASAVEAIPQKVLMQFINELPAGYRTVFNLYTFEDKSHKEIAQMLGINEKSSASQL
                     FRAKSVLAKKVKEWLVTNG"
     CDS             8506..9768
                     /locus_tag="ctg52_90"
                     /transl_table=11
                     /translation="MMKEDEKWIKAFKDKLEDYSEPMPASGWERLERELMPVTEKRIYP
                     YRRWAVVAAAVVLVVTTAVSLYFLNSPVADEIRYATAPSLAVNPDVLPEPALPDVQVAV
                     SEPVKPVGTTSINPVSGYLAKNTDPVIVPEVSSLAEKRPEAVTEEKRAEPQQEATAAIE
                     KKESATAQPPKRKEARRPSGKDKYQLPIGDSSAKRGGRWSMGVGIGNGGGLPTNGSENF
                     APRPMTNRVDLMTIMNGAVSIPADQEVIFEEGVPYLKSNTTAVVDYEHHQPVSFGLSVR
                     KSLPKGFSVETGLTYTLLSSDIKRQGDTKMQSQKLHYIGIPVRGNWNFLEKKYFTLYVS
                     AGGMVEKCVYGKLADDKVNVKPLQFSVAGAVGAQFNATDHVGLYVEPGVSYFFDDGSKV
                     QTIRKERPCNFNLQAGLRFTY"
     CDS             complement(10001..10726)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 72.3;
                     E-value: 1.6e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_91"
                     /sec_met_domain="Radical_SAM (E-value: 4.6e-30, bitscore:
                     97.8, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINVHSYESMGTFDGPGLRLVVFLQGCNFRCLYCANPDTIEAKGG
                     TATDPEEIVRMAVSQKAFFGKKGGITFSGGEPTFQAKSLIPLFKRLKEAGIHICLDTNG
                     GLWNNDVEELLELTDLVLLDIKEFNPEHHQSLTGRSNEQTLKTAAWLETNHKPFWLRYV
                     LVPGYSDFEDDIRQLGEHLGTYQMIQRVEILPYHTLGVHKYEAMNKEYMLKGVKENTPE
                     QIEKAEKLFRQYFRTVQVN"
     CDS             complement(10731..12959)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_92"
                     /sec_met_domain="Gly_radical (E-value: 3.4e-46, bitscore:
                     148.8, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate1 (E-value: 0.0, bitscore:
                     1166.2, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELNKTFKDGLWSKEINVRDFVSNNITPYEGDASFLQGPTERTKA
                     VWNHCLKALEEERNNNGIRALDYTTVSTITSHPAGYIDKENELIVGLQTDQVLKRAIKP
                     FGGINVVMKACRENGVEVDDRVKDIFTHYRKTHNDGVFDVYTDEIRSFRSLGFLTGLPD
                     NYARGRIIGDYRRLALYGLDRLIEAKKEDLHNLTGPMTEACIRLREEVAEQIKALKEIK
                     VLGEYYGLDLSRPAYTAQEAVQWVYMAYLAAVKEQDGAAMSLGNVSSFLDIYLEYELSQ
                     GTITETFAQELIDQFVIKLRMVRHLRMQSYNDIFAGDPTWVTESIGGRFNDGRTKVTKT
                     SFRFLQTLYNLGPSPEPNMTVLWSPELPEGFKAFCAQVSIDTSSVQYENDDLMREVRQS
                     DDYGIACCVSYQEIGKQIQFFGARANLAKALLLAINGGRCENTGTVMVKDIPVLTGETL
                     KFEEVMANYKKVLIQIARVYNEAMNIIHYMHDKYYYEKAQMAFVDTDPRINLAYGVAGL
                     SIAIDSLSAIKYAHVKARRNDIGLTEGFDIEGAFPCFGNDDDRVDHLGVDLVYFFSEEL
                     KKLPVYKNARPTLSLLTITSNVMYGKKTGATPDGRAKGIAFAPGANPMHGRDKNGAIAS
                     LSSVAKLRYRDSQDGISNTFSIVPKSLGATQEDRIDNLVTMMDGYFTKGAHHLNVNVLN
                     REMLQDAMEHPEKYPQLTIRVSGYAVNFVKLSREHQLEVISRSFHERM"
     CDS             13572..14801
                     /locus_tag="ctg52_93"
                     /transl_table=11
                     /translation="MKSTFKVLFYLKKGSEKKNGEVMIMARITIDGKLCQFSTKQSIQP
                     DNWSIAAGKAKGRDAGRINALLDDIRSSLNTIYHEMQRRDNYVTAEKVKNEFLGHSESH
                     ETILSLFQKHNDDVKQLVGISKTIATYRKYEVTRRHLAEFIQSKYNVSDISIKEISPMF
                     ITDFELYLRTACKCGYNTTAKFMQFFKRIIIIARNNGILVGDPFASYKIRLEKVDRGYL
                     TEDEIKIILKKKMVSERLEHVRDLFVFSCFCGLAYSDVANLRQENIQKSFDGNLWIITK
                     RVKTNTDVNVPLLDIPKMILKKYKGKLPDGKILPVISNQKLNAYLKEIADICGIKKNLT
                     FHLARHTFATTTTLSKGVPIETVSKMLGHTNIETTQIYARITNSKIGSDMQGLDKKFVG
                     IEKIYKEVAM"
     CDS             14886..15416
                     /locus_tag="ctg52_94"
                     /transl_table=11
                     /translation="MDLQIIQNKIFEVRGCRVMLDYHLAELYQVETRALKQAVKRNIER
                     FPGDFMFVLTQEEANLLLSIGVSQNVIPPAYNFGVAMPMAFTEQGVAMLSSVLRSKVAI
                     EVNISIMRTFVLMRQMAIGYEELSRRIEELEVSTDAQFNELYQALTQLLSQSKQQKERR
                     PVGFVTYNRDKNE"
     CDS             complement(15388..15519)
                     /locus_tag="ctg52_95"
                     /transl_table=11
                     /translation="DIKNAGSRWTARKVEECTSLGYSLLGGISLPKSLPIRFCHGYR"
ORIGIN
        1 tacgggacgg ttacttgtga ttgatggcga gcctcaaagt attcatccgg aaaccgggcc
       61 ttactttgac tatttcattg tgcaggcata ctctaacctt gcgggtaatt ccgacgctaa
      121 tcttgacaga cgtctggctg gtacgattgc caactttaaa ggaatacttc ctccggagaa
      181 agtggctaat atgtacatcg ttacggagaa tttcgaatct tatgctccga caggaggagg
      241 tgattatgta gatcgttacg gaaacaaaat gagagcactt gccggcatgg cacgctggac
      301 tccgactatt gacggaaaac aggtacggaa gggtggagta ggcacctatc acatggaata
      361 tgactatccg ggcgacatcg aatataagta cctgcgtgaa gcaatcagaa taatgaatcc
      421 tgctgtaaaa tgactttaaa gaatttgatt atgaaaagaa taacaataaa acaatgtttg
      481 cttgcctgtt tcgttctgcc gatgatcctg gcaggatgca acgatgccga ttaccaggtt
      541 atcgacaatg cgatttattt gaatgaagca tccgagaatg gttcggcaaa ggttaccgtt
      601 gatcctgaaa atgtaacaac aactactctg accgtacgtg tgggacagcc tgtaaccgaa
      661 aatgtgactg ctgtcctgac ggtagatcct tctattctta aagagtacaa tgaagctaat
      721 gaaacttcgt acgaagtcct tcccgagcag tattttactt atgacaaaga gataaagata
      781 gcggcaggcg atgttagcgc aatccccagt gagtttagag tgaaacctta ttcaaacgaa
      841 aacggagaat tgtatgctat tccggtatct ctcacagaaa ttcagggacc ggtgtccaca
      901 atcgggcttt cgtcgaagtt tatcattttg ctggataagc cgctgataca gtctgtaccg
      961 tttatgaata cgaccaatgc cgtgaagccc gccaaggacg aattgtgggg agtgacaacc
     1021 aatgaatggt cactcgaggc ttgggtacag atggacggat tcgatattaa taatcaggct
     1081 atatttaatt cgggcagcag cgaccacgag gtttatatcc gtttcggtga cgctatgatc
     1141 ccttataatt cattacaggt gaagacactt ggaagtcagg tcaatacggt gactttgttt
     1201 gagaagaata agtggtatca tctggccttc gtttataatt cttccgggtt attgtcgatt
     1261 tatatcaacg gagtgctcga cgtgactctg cagacaaagg gtggcccggt aagattcgac
     1321 aagatgaaca tggtttcgag cggtagctac ttccgcaaca attgtcagat ggcccaggtg
     1381 cgtctttgga agagcgcaat cagccagacg caaattcagt ccaacatgta ttttgccgtg
     1441 aaacccgccg atccgaacct gataggctat tggaaaatgg atgaaggtaa aggaaatgcc
     1501 tttgccgact gtaccggaca cggatacgat ttggtggcag gaggaactct tgtctggaaa
     1561 gagcatgttc gttttgataa gcaataacta tgtaaaaaga agataagata tgaatagaca
     1621 tttgaatttt gtgaccttaa tctgcctgat aacaggcttt gtatcgttgg cttcgtgcag
     1681 caacgatgat gatgaaatgg acaaatatca aaagatatat atcagaacgg gagttgcacc
     1741 gggggccgaa atgggtgctg cggtagtggt ggattgtgtg agcaattcct ctactgccga
     1801 ccgttctgat tttgaaatac aattgtgtgc cgtacagccg gttacgcggg atgtcactgc
     1861 cgctttggga gtagatacgc tgaaagtgga tacttacaat tctgccaata agacgaaatg
     1921 taagttgttg ccccaagata attataccat tgaaacaagt gaagttgtct taaaaacggg
     1981 acagacagtg gccgattcat cttttcaggt cgttttgaag aatatagaaa agttgactaa
     2041 tcctgacgga tatgtgcttc ccgtggcgct taaaggagtt acgggcatgg acgaacaggc
     2101 tgtcagtaca tctatgaaga cggtttatat ccggatttat accagcgtgc tttataccag
     2161 ttatacgaaa cccgggaatt ggtccgctgt agatcgaagt gcgtggagtg taagttgcag
     2221 caatgtttat gccgatgatg atgccaaata tggtgcacat ctggctattg acggtgagat
     2281 aaatactact tggtttacat ggggagtggc taatgccgga gagtgttggt ggaatacgct
     2341 actggaccga cctgttacct taaccggatt ttcggtcact aaacagagtg cctacggttc
     2401 gggttataat ctgagaagtg ctgagattaa ggttcggaaa gagggtgaaa ccgagtgggt
     2461 tacttacccg agagtcttga ctttcagaaa ttttaaaggg gctgatccgc aatatgcggc
     2521 catcgaacca cctatcccga atgtaaagga attcagaata aactgtctga ctccggataa
     2581 ttataccggg tttgctgaga taaatttata tgtgaagcaa tagaggtgtt tagattgtag
     2641 ataagggggc gagaggcatc ggggatgaaa gtcttcggtg cttctttgcg tgtattgtat
     2701 tgataaagtt taataaaaaa agggtgatag aggttagtag ttttcccggg tgagttgtat
     2761 tattaaataa tgaaagcaac ttcttgtcgt aatcttgggt tatgttttta atatccccta
     2821 tctttgctta ctggaattgt taaccgatgg aattattata aaaaactaac tgatgaataa
     2881 aaagccgata agccctgtat gttgggtgcc tactgtttac tttgctatgg gattgccgtt
     2941 tgtggccctt tcgatggttt ctgtccttat gttttccgat atggaagtgt cgaatgcaca
     3001 gattgctttc tggacttctc tcattatgct tccctggaca ttgaagcctt tatggagtcc
     3061 gtttctggaa atgtttaaaa cgaaaaaata ctttgttgtc gctacggaaa tcattaccgg
     3121 actggcattt gcattggtag cactttcgct gccgctgccc gacttttttc gttatgccat
     3181 cgctctgatg gggatcattg ctctcagtgg tgcgactcat gacattgcgg gtgacggagt
     3241 atacctgact gaactgactg ctacccagca agccaagtat atcggttggc agggagcttt
     3301 ttataatctg gccaagatac ttgccaacgg aggcttggtt tggttggcag gtatgctgaa
     3361 ggatgaattt ggagtggtac atgcctggat gattgtcatg ttgatgtgtg cgggtattat
     3421 gattctgatc ggtctttacc acatccggat tttgccttcg ggaggaggcg cttccggtga
     3481 agtgaatacg atgagtgacg cattgaatat gctttgggaa gtcatccgct cttttttcca
     3541 aaaaaaacat attgctttct acattgtctt tatcattttg taccggtttg ccgaaggata
     3601 tgccatcaag attgtaccgt tgttcctgaa agcgtcggtt gcggatggtg gattgggact
     3661 cagcactcag gatatcggac tggtatatgg tacgttcgga gcgggagctt ttattctcgg
     3721 ttcgcttttg gccggttatt acatttcggc tttcggactt cggaagactt tgttttcttt
     3781 atgttgcgct tttaatattc cgttcttggt atatttcctg ttagcccttt accagccttc
     3841 cgatctatgg attattggta tggccattgt gtctgaatac ttgggttacg ggtttggttt
     3901 tgtcggattg atgctcttta tgatgcagca agtggctccc ggcaaacatc agatggcaca
     3961 ttatgctttt gctaccggta ttatgaatct gggggtgatg cttcccggaa tgatgagcgg
     4021 atacctgagc gattggctgg gttatcgcga tttctttatc tgggtactta tcgctaccat
     4081 accggctttt atcgtgactt ggctggtacc tttcacatat ccggacggaa agaagaaata
     4141 aaaagagatt ttcaatataa acaagatata tacataatat taatttaatc gaatcatgga
     4201 agaaattaaa attgcaggtg ctgctttgcc ggctatgcct tgggaagaac gtccggcagg
     4261 atgtaaagat gtagtgtggc gttgttcggc caatccgatt attccgcgcg acttgctccc
     4321 tacttcaaac agtatattca acagtgccgt agttccgttt aaggatggct atgcaggggt
     4381 gttccgttgt gatgatacta atcgtcgcat gcgtttgcat gtgggattca gcaaggatgc
     4441 tgttcattgg gatatcaacg aagaaccgtt aaagtttcaa tgtgatgatg ctgaggttgg
     4501 aacctgggtc tatggatatg acccacgggt ttgctttatc gaagaccgct actatgtgac
     4561 ctggtgtaat ggctatcatg gtcctactat cggtgtggcc tacacctatg attttgttac
     4621 ttttcaccag ttggagaatg cctttattcc tttcaatcgg aatggagtct tgttccctcg
     4681 taagataaac ggtcgttttg cgatgttgag ccgcccgagt gataatgggc atactccttt
     4741 tggagatatt ttctatagcg agtctcccga tatggagttc tggggacgtc atcgtcatgt
     4801 tatgtcgccg gctccgttcg aagacagtgc ctggcagtgt accaagatcg gtgcagggcc
     4861 tatcccgatt gaaacctcgg aaggctggtt actgatctat catggtgtat tggcttcctg
     4921 caacggtttt gtgtatagtt ttggttcggc actgcttgac atcgatcagc cctggaaagt
     4981 aaaattccgt tcggggcctt atctgatttc acctcagaag gattacgaat gtatgggtga
     5041 tgtgcctaat gtctgtttcc catgcgcagc gcttcatgat tcggagaccg gacggattgc
     5101 catctattat gggtgtgcgg atacagtgac cgggctcgca ttcggataca ttccggaaat
     5161 tattgaattt accaaacgta caagtatcat ctgaatcgaa taaaacagaa agggtgtagc
     5221 tatcccgccg ggatggctac acccttttgc ttgtatggct acaccctttt gcttgtatgg
     5281 ctacaccttt tcggtcagat ggctacaccc tttcggctgt tatccgttgt atgcagtcag
     5341 catccaaacc atcttttcct gttctttcag gtagtcgctc atcatggcca ctgttacttc
     5401 gtcgttgtgt gaagaggcga gagacaggat tttacgttct tccgcaatca gatgcccgta
     5461 agtttcgaga atatgattca gagcgtcgtc ggccttattc actccgtcca cttccttgat
     5521 ctgcgccatc ttcagatagt cactgtattt attggcggga gttcctccca gcatcagtat
     5581 acgttcggct atttcgtcta ccttttcggc ggctccatta tataaatctt caaacttgct
     5641 gtgcagtacg aagaaaccgt gtcctttgat gttccagtga aatcctctca ggtttgcata
     5701 atgaatctga aaatcggcaa gcagttgctg taatgacagt acgatggtgt tagctccttt
     5761 ttcttccaaa tgtgtataat ttaaagtctt cataatgata ttgttttttt tgagttaata
     5821 ctatatttct tctttttatc tggaacaaag atacggcaca aaatgattcg tgtcaaactg
     5881 aaaatttcta tctttgcatt gatagattct atatctttaa taaatcagag aacgatgact
     5941 atacaacaat tggaatatat tctggctgtg gaccagttcc ggcattttgc taaagctgcc
     6001 gagtattgcc gggtgacgca acctactttg agtgcaatga tccaaaagct ggaagacgaa
     6061 ttgggggtga aactgttcga ccgtagcatg acaccggttt gccctactgc cattggtaag
     6121 aaagtgctgg aacaggcccg taagattctt tcggaagtta tctgtgtcaa ggagatcatc
     6181 agcgaagaac agcactccct gtcgggtaca ttccgattgg cagtgttacc gacgattgca
     6241 ccttatcttc tgccccgttt ctttccgcaa ctgatggaga aatacccgga tcttgatata
     6301 cgggtgatgg agatgaagac gcccgacatt cgcaaggctc tgctgaccgg tgaagcggat
     6361 gctgctatca ttgccagcat gctggatgat gccgcattaa cggaagagac cttattctac
     6421 gagcaattct tgggctatgt ctcaaagaag gaaccgttgt tcaagcacga tgtgattcgt
     6481 acgtccgatg tgacagggga acggctttgg cttcttgacg aagggcattg cttccgcgat
     6541 cagttggttc gtttttgtca gatggaagcg gttaagatca gccaaatggc gtatcggctg
     6601 ggtagtatgg aaacctttat gcatatggtg gagagtggta aggggattac gtttattccc
     6661 gaactggcag tgatgcaatt gagcgaagag cagaaagaac tggtccgtcc gtttgctatc
     6721 ccgcggccta cccgtcagat tgtcctggtg acccggaaag acttcatccg caccagtctg
     6781 ctgcaggttt tgaaagagga gattcaggcg gcggttccca aggagatgct taccctgcag
     6841 gccgttcagt gtctggtata atataaaaac gacggcgata ttttcacaaa catcgccgcc
     6901 ttatttcttt tatgtatcag aattattact cgttttgcct gattgtgtag gtgtttcttg
     6961 ttgttttatt gagaatgaaa tgattttatt tttaagtttt tgtcttcgtt gatatctatt
     7021 gtgacatact gtatattgtc ataaatggtg ttcacacgga gttttattcc tttggctgtc
     7081 gccaattgct cggctatact atccagcttg aaagaaacaa ggctcgaacc caattgattg
     7141 ggggagtcat taaaggcatt atgccggaac tccagataga tatatccgtc atcttttatg
     7201 ggacctgtta tttcgttttg taccaagttc agcatgtgtt ttttattttc attcatgctg
     7261 cccagatatt gatattcgat ggtcagataa tctttcgtaa gtgcatgcgc tgtgacgttg
     7321 atacggtcgt ctccaatgct gtctgctgta gcttccgtca gtggaatgat ctctttcgtc
     7381 aatatatctt ctatcgtgaa tattttaccg ttctcatatc cgggcttctc ttttcccatc
     7441 tgcagatagc caacgaagac tctttgacct tctgcaacag tgtatttcct gttgcgtata
     7501 tcggccgtat ctgccggaag tacattgtct ccattgtcca atgcaatgaa aaagtccctt
     7561 ggagtgtccg cattgggaat cttcattgtg ccgatggcca atattccacc cggaggacaa
     7621 gtgacccact cgtcgttgtt ggcatcgtcc agacatgact gtaaaatggg caataacatc
     7681 aggatgacgg caaaagttat taaattaaat ttcttcataa gtttcttgtt ggttttatcc
     7741 tatttatcca ttgagattta ttctttattg tattgagaaa atgcaggaag tgatgaaata
     7801 ttgcatccta aaatgttaaa gaaacaaaag tgataaaaga gttgttctct ctgtgcagta
     7861 tttctatctt tgctgcattt ataaggtaaa cacgtgttta ggagaatgaa tgaattagag
     7921 ctgtcggaac gttgcaggca gggagataat cgtgcccgca aagaacttta tgagcagtac
     7981 gcagggcgca tgcttggtgt ctgtcttcgt tatgccggag acagggacat ggcacaagac
     8041 ttggtacacg acggtttcct gaagattttc gactccttcg acaagtttac ctggcggggt
     8101 gaaggctctc tgagagcatg gatggagcgt gtaatggtga atacggtttt acagttctta
     8161 agaaagaacg acgtgatgaa ccagaccacg gcactggatg aagttcccga aacgtatgaa
     8221 gaaccggatg cttcggctgt tgaagcaata ccacagaaag tgctgatgca atttattaat
     8281 gaactccccg ccggatatcg taccgtattc aatttataca cctttgaaga taagtcgcac
     8341 aaggaaatcg cacagatgtt ggggattaat gaaaaatctt ctgcctcaca gctttttcgc
     8401 gcaaaaagtg tattggcaaa gaaagtgaaa gaatggttgg tgaccaatgg ttgacatgta
     8461 tttacagata ctgaggtgaa ccttggattt caaaaatgaa atagaatgat gaaagaagac
     8521 gaaaaatgga ttaaagcatt caaggataag ctcgaagatt attcggagcc gatgcctgct
     8581 tccggttggg aacgactgga aagggaactg atgcctgtaa ccgaaaaacg aatatatccg
     8641 tatcgccggt gggcggttgt tgcggcagct gtggtattgg tggtaacgac tgctgtcagt
     8701 ttgtattttc tgaatagtcc ggtagctgat gaaatccgtt atgcaacggc tccttcactg
     8761 gctgtcaacc cggatgtatt gccggaacct gccttgccgg atgtacaggt agctgtatcc
     8821 gaacccgtta agccggtagg aacgacgagt atcaaccctg tttcgggcta tttggcaaag
     8881 aatactgatc cggtgattgt tccggaggta tcctccctgg cagagaagcg accggaggca
     8941 gtgacggagg aaaagagagc tgagccgcaa caggaagcaa ctgctgcaat cgagaaaaaa
     9001 gaaagtgcga cagcgcagcc tccaaagagg aaagaagcgc ggcgaccgtc cggtaaagac
     9061 aagtatcagt tgcctatcgg agactcttct gctaaacgtg gtggtagatg gtcgatggga
     9121 gtgggtatcg gtaatggagg tggacttccg acaaatggtt ccgaaaattt tgcgccccgt
     9181 ccgatgacta acagggtcga cttgatgacg atcatgaatg gagctgtgag tattcctgcc
     9241 gatcaggaag ttatatttga ggaaggggtt ccttacctga agtccaatac aactgccgtg
     9301 gtggattatg aacatcatca gccggttagc ttcggactgt ctgtacgtaa gtctcttccc
     9361 aaaggttttt ctgtagagac gggattgact tatacgttgt tgtcttctga catcaaacgg
     9421 cagggggata ccaagatgca gagtcagaaa ttgcattata taggtattcc tgtacgtgga
     9481 aactggaatt ttctggaaaa gaaatatttt acactctatg tatctgccgg aggaatggtt
     9541 gaaaagtgtg tttatggaaa gttggcggat gataaggtga atgtgaagcc tttgcaattt
     9601 tctgtagccg gtgccgtggg agcgcaattc aatgcgacag atcatgtcgg cctatatgtg
     9661 gaaccgggag tttcgtattt ctttgatgat ggctccaaag tacaaaccat ccgaaaagaa
     9721 aggccttgta actttaactt gcaggcagga ttgcgattca cttattaaag taggatggca
     9781 aaaaatatgc cggttacatt atctccctgt tcttgccttg tattgtaatg aattaaggca
     9841 agaacaggga gacttttata tcgtgactta caaaattata aataagtgca gtcgtcataa
     9901 ttcaccgcag aatgaactta atctgttgat tgccaatgaa tctttatctg tgtaaattcg
     9961 tgtaatctgt ggcgaatacg aatttcgaca cttatataag tcaattcact tgtacggtcc
    10021 ggaagtattg cctgaatagt ttttcagcct tttctatctg ctccggagta ttctctttca
    10081 ctcctttcag catatattct ttgttcattg cttcatattt gtgaacaccc aaggtgtggt
    10141 aaggcaatat ttctacacgc tgaatcatct ggtacgttcc aagatgctct cccagctgcc
    10201 ggatatcgtc ttcgaagtca ctgtagccgg gcactaatac gtatcgcaac cagaatggtt
    10261 tatgattggt ttcaagccag gctgcggttt tcagggtctg ctcgttgctt cttccggtta
    10321 aagactgatg atgttccgga ttaaattctt tgatatctaa taaaaccaga tcagtcaatt
    10381 ccaatagttc ctctacatca ttgttccata gcccgccatt ggtatcaagg caaatatgga
    10441 ttcctgcttc ctttagtctt ttaaaaagtg ggataagcga ttttgcttga aaagtaggct
    10501 ctccaccgga aaaggtgata cctccctttt taccgaagaa agctttctga ctgacggcca
    10561 tgcgaactat ttcctcaggg tcggttgctg tccctccttt ggcttcaatt gtgtccggat
    10621 tggcacaata gaggcaacgg aagttacacc cttgaaggaa aacgacgagc cggagacccg
    10681 gcccgtcgaa tgttcccatt gactcgtatg agtgtacgtt tatcattcaa ttacattctt
    10741 tcgtggaaac tgcggctgat tacttccaac tgatgttcgc ggctcaattt cacgaaatta
    10801 acggcatatc ctgagacacg gatagtcagt tgcggatact tttcgggatg ttccatcgca
    10861 tcctgcaaca tttcccggtt cagcacgttt acgttcaggt ggtgtgcgcc ttttgtaaaa
    10921 tatccgtcca tcatggtcac cagattgtca atacggtcct cttgtgttgc tcccaatgat
    10981 ttgggaacga tcgagaatgt attgctgata ccatcctgtg agtcgcgata acgcaacttg
    11041 gctacagaac tcagtgaggc gattgcacca tttttatcac gtccgtgcat ggggttggca
    11101 ccgggagcaa aggcaatgcc tttggcgcgt ccgtcaggag tggcaccggt cttcttgcca
    11161 tacattacgt tcgaagtgat agtcagcagc gagagggtag gacgggcatt cttatatacg
    11221 gggagtttct ttaattcttc gctaaagaaa tataccaggt ctacacccag gtggtctaca
    11281 cggtcatcgt cattaccgaa acaagggaaa gcaccttcga tatcgaatcc ctccgtcagt
    11341 ccgatgtcgt tgcgacgggc tttcacatgt gcatatttga tggcggacag tgaatcgatg
    11401 gcgattgaaa gtccggctac accataagcg aggttaatgc ggggatcagt atccacgaaa
    11461 gccatctgcg ccttttcgta gtaatactta tcgtgcatgt aatgtatgat attcattgct
    11521 tcgttgtata cacgtgcaat ttgtatcaat actttcttat agttggccat tacttcttcg
    11581 aacttcagtg tttcaccggt caatacaggg atgtctttta ccataactgt acctgtattt
    11641 tcgcaacgtc ctccgttgat agccagtagc agggctttgg caaggttggc acgtgcgccg
    11701 aagaactgaa tctgctttcc gatttcctga tatgaaacac aacaagcgat tccgtagtca
    11761 tccgattgac ggacttcacg cattaggtcg tcgttttcgt attgtacgga agaagtgtcg
    11821 atagatactt gtgcacagaa tgctttgaaa ccttcgggta actcagggct ccatagtaca
    11881 gtcatgttag gttccggtga cgggcctaag ttataaagtg tctgcaagaa gcggaaagaa
    11941 gttttagtaa ctttggtacg tccgtcattg aaacgtccac cgatagattc ggtcacccat
    12001 gtgggatcac ccgcaaaaat atcgttgtac gactgcatac gcaagtggcg taccatacgg
    12061 agtttgataa cgaattggtc gatcagttcc tgagcgaatg tttcggttat cgtaccctgg
    12121 cttaattcat attcaagata gatgtcgagg aatgaagata cattacccag tgacatggca
    12181 gcaccatcct gctcttttac ggcagccaga taagccatat acacccattg tacagcttcc
    12241 tgtgcggtat atgccggtcg gctcagatcc aaaccataat attcgcccaa tactttaatc
    12301 tctttcaggg ccttgatttg ctcggctact tcttcacgaa gacgaatgca ggcttcagtc
    12361 ataggacctg tcagattatg cagatcttct tttttagctt ctatcagacg gtcaagacca
    12421 tagagagcca ggcggcgata atcaccgatg atacgtccgc gtgcatagtt gtcgggaagt
    12481 ccggtaagga atcccaatga acggaacgaa cgaatttcat cggtatacac atcgaatacc
    12541 ccatcattat gagtcttgcg atagtgagtg aagatatcct taactctgtc atctacttcc
    12601 actccgtttt cacggcaagc tttcataacc acattgattc cgccaaacgg tttgatggca
    12661 cgttttaaca cctgatcggt ctgtagtccg acgatcagtt cgttctcttt atcgatgtag
    12721 ccggcagggt gagaggttat agtagataca gttgtgtagt cgagtgcacg aataccatta
    12781 ttgtttctct cttcttcgag agctttgaga cagtgattcc agacagcttt ggtgcgttcg
    12841 gtaggtcctt gcaggaaaga agcatcccct tcataaggag tgatgttgtt actaacgaaa
    12901 tcccttacat tgatttcttt gctccaaagt ccatctttaa aggtcttatt cagttccata
    12961 aaattaatca gttagtggtt agttatcctt tagagcgcgc aaatttacaa ccttttttcg
    13021 gtttaggtat ataaaagggt cctattttat gttgaatagc ataaaaatac ctatttatgg
    13081 ggagaagcca gagggcggtt attacttcca aatatacttt tctaatattt ttttatggaa
    13141 taatttgcaa gttaaaaaat gattcgtacc tttgcagcgc tttaagagaa aagcactact
    13201 taaccgtagt tctggagagg tggcagagtg gtcgattgcg gcggtcttga aaaccgttgt
    13261 actgcgaggt acccggggtt cgaatccctg tctctccgct gaacgtgctg gacagaaatg
    13321 gtcagcaaac ggacaaaaag ctacaaatca atgatttgtg gcttttttta ttgcccgaaa
    13381 gtcctgcttc caagacttca aaagtacggt aaaagacaaa gtttcgttac taaatcgtta
    13441 cctattccct gccggacaaa aacggtaacg aattgtccat aaatgacctg ataatgacta
    13501 tattagtcca tagtctgcat aactcgaaaa cgagaggtaa aaactaattt tgcaactaaa
    13561 aattttgagt tatgaaatcg acattcaagg ttctttttta tttgaagaaa ggttctgaaa
    13621 agaaaaacgg cgaggttatg attatggcac gcatcaccat agacggcaaa ctttgccagt
    13681 tcagtacgaa acagagcatc cagcccgaca actggagcat tgctgcgggc aaagccaaag
    13741 gcagggatgc cgggaggata aacgcccttt tggacgacat acgttcttcc ctgaatacca
    13801 tttaccacga aatgcagcgg cgtgacaact acgtgaccgc cgagaaagtg aaaaacgagt
    13861 ttttaggtca tagcgagagc cacgaaacaa tcctttcatt gttccaaaag cacaatgacg
    13921 atgtgaagca gcttgtgggc atatccaaga cgatagcgac ctaccgcaag tatgaagtga
    13981 cccgccgcca cctcgctgaa tttatccaaa gcaagtacaa cgtatcggac atatccataa
    14041 aggagataag cccgatgttc attaccgatt ttgagttgta tttgcgtacc gcctgcaagt
    14101 gcggctacaa caccaccgcc aagttcatgc agttcttcaa gcgtatcatc atcattgccc
    14161 gcaacaacgg catactggtg ggcgacccgt tcgccagcta taaaatccgg ctggagaaag
    14221 tggacagggg ttatctgaca gaggacgaga taaaaatcat ccttaaaaag aaaatggttt
    14281 ccgaacggct ggaacacgtc agggacttgt tcgtcttttc ctgtttctgc ggtttggcat
    14341 acagcgatgt cgccaacttg cggcaggaga atatccaaaa gtcctttgac ggcaaccttt
    14401 ggataatcac caagcgggta aagaccaaca cggacgtgaa tgtccccctg ctggatattc
    14461 ccaagatgat tttgaagaag tacaagggca agttgccgga cgggaagata cttcccgtaa
    14521 tcagcaatca gaagctaaac gcctacctga aagagattgc cgatatatgc ggtattaaaa
    14581 agaacctgac gttccacctt gcccggcaca cgttcgccac gaccaccacg ctgtcaaagg
    14641 gcgtacccat tgaaacggtg tccaagatgc tgggacacac aaacatagaa actacgcaaa
    14701 tctacgcccg catcaccaac agcaagatag gcagcgatat gcaggggctt gacaagaagt
    14761 ttgtcggcat cgagaagatt tacaaggaag tcgccatgta atcttgatta ttgggaactg
    14821 gtcacaattt gtgaccagtc cttactatta ttccaacatt gctaaatctc ctaaaatata
    14881 cgattatgga tttgcagatt atccaaaaca agatttttga ggtcagaggt tgccgggtga
    14941 tgctcgatta tcatttggca gaactctacc aagtggaaac acgagccttg aagcaggcgg
    15001 tcaagcgcaa tatcgagcgt tttccgggtg attttatgtt tgtactcacc caagaggaag
    15061 ctaacttgct gttatccata ggggtatcac aaaatgtgat accccctgct tacaacttcg
    15121 gcgttgctat gcctatggct ttcaccgagc agggcgtagc catgctttct tcggttctcc
    15181 gctccaaagt agccatagaa gtaaacattt caatcatgcg gactttcgtc ctcatgcgcc
    15241 aaatggcaat cggttacgag gaactgtcaa ggcgcatcga ggaactggag gtaagcaccg
    15301 atgcgcagtt caacgaactg taccaagccc ttacccagct tttgagccag tcgaaacaac
    15361 agaaagaacg ccgtccggta ggtttcgtta cctataaccg tgacaaaaac gaataggtaa
    15421 cgatttcggt aacgaaattc cgcctaacaa actatatccc aatgaagtac attcttccac
    15481 cttgcgggca gtccaccgac tacccgcatt ttttatatc
//
