LOCUS       gnlProkkaEGIBHFOI_291  10606 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EGIBHFOI_291.
ACCESSION   gnlProkkaEGIBHFOI_291
VERSION     gnlProkkaEGIBHFOI_291
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 17:43:54
            Original ID  :: gnl|Prokka|EGIBHFOI_291
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10606
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10606
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1292:5606]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1293..5606
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..10606
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10606
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             81..1229
                     /locus_tag="ctg291_1"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             1293..2012
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 54.5; E-value:
                     1.6e-16)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg291_2"
                     /sec_met_domain="NTP_transf_3 (E-value: 2.3e-16, bitscore:
                     50.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             2033..3334
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg291_3"
                     /sec_met_domain="CTP_transf_like (E-value: 2.7e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 2.8e-121, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 3.2e-63, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             3351..4475
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg291_4"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.5e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.3e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             4485..5606
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg291_5_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg291_5"
                     /sec_met_domain="Aminotran_5 (E-value: 2.1e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        4575..5582
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg291_5_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg291_5_Aminotran_5.1"
                     /locus_tag="ctg291_5"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             5603..5746
                     /locus_tag="ctg291_6"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             5949..7433
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg291_7"
                     /sec_met_domain="Polysacc_synt (E-value: 1.9e-31, bitscore:
                     99.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLS
                     FLFKLDSFFCILTLIIKTKNIDENIKKDFSSNSKDN"
     CDS             7387..8646
                     /locus_tag="ctg291_8"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             8655..9404
                     /locus_tag="ctg291_9"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKNSK"
     CDS             9404..10444
                     /locus_tag="ctg291_10"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 aggttatgct acttccttca gttctttggg aatgatgatt gcttctattg ctaatttgat
       61 aaagaaataa atgacctatt atgattgaaa agcaatctta tcaagaaccg ttttctgaag
      121 tggataaaag gaaagatgat gaaatggaaa tagacttgat ggctattttt tataagatta
      181 ttactgttcg tggagtacta tgcaaagctg ctggagtggg agtaataatt gctatagtgg
      241 tggcattgag cattcccaag caatatacag taaaggttac cctttctcct gaaatgggta
      301 atgcgaaggg aagtaatggt ttagccggac ttgctgcctc gtttttggga gatggggctc
      361 taatagggga aagcacagat gccttgaacg cttctctttc agcagatatt gtttcttcaa
      421 ctcctttttt attggaactt ttagaaatgg aagtctccgt ttctaaaaag gatgataaaa
      481 tgactttggg gtcttatctc gatgaagagt catctccttg gtgggattat cttataggtt
      541 ttccgggcat agtaatagga ggagttaaat cattattcgg agaagatacg gttcctgcca
      601 gtggagggcg gcaaggaact atcgaattga cgaaagaagt aaatgagaag attaattttc
      661 ttaaaaagaa gattagtgca tccattgata agaaaaccgc cataacgagc attacggtca
      721 ccttacaaaa tccgcagatc actgcggtta tagcagattc tgtcgttcat aaattacagg
      781 aatatattat tgggtatcga acttcaaaag taaaagaaga ctgtgcgtat ttggaacggt
      841 tgtttaaaga acgtcagcag gaatattatg ctgctcaaag aaaatatgcg gattatgtag
      901 acgcccatga taatgtggtt cttcaaagtg tacgtgctga gcaggagcgt ttacagaacg
      961 acatgagttt ggcttatcag atatatagtc aggttgctaa tcagttgcag gtatccagag
     1021 ccaaagtaca ggaggaaaag ccagtctttg cagtagttga gcctgccgtt gtacctttga
     1081 aaccttcagg tatgggactc aaaatttata ttttattatt tgtgttcctg tccgtatctg
     1141 gtactctcgt gtgggtgttt tttggcaaaa gtctgctggc tagcttgaga aaagaactga
     1201 aaaataagga gatagaacag gataaatgat gctaaaacgt cgtttacaac attcttacat
     1261 caattaaatt cacttactat attattaaac gaatgatacg tacagctatg ataatggctg
     1321 cgggcatggg aacccgtttt ggccaatata cagaattgat acctaaaggg ttcgtcaaag
     1381 tgggaggtat tccaatgata gttcgttcta ttgatacttt gttatcatgt gacattgagc
     1441 gaattgtaat cggtacagga tataaacaag aagtttatga agaattgaag acagactatc
     1501 ctatgcttga aacctgtttt agtcctcgtt atgctgaaac aaatagtatg tatactttat
     1561 ataatacgcg ggagattctg ggcaatgatg attttttatt gttagagtca gatttgattt
     1621 ttgagaaaca agcaataatg agcttattgg agtgtcctgc ggcagatgca atgctaataa
     1681 ctccagtgac aaagtttcaa gatcagtatt atgtggaaca tgatgataat tttcgccttt
     1741 cttcatgttc tgtcaataag aataaactaa acgctaaagg cgaattggtc ggcatccata
     1801 aactatccgg ttccttttac aaaataatgt gtgctgatta tgcgagtatt gttgatgaac
     1861 aacccaattt gggatatgag tatgaattac tacgaatatc ttgttctcaa tctcctgttt
     1921 atgtgcataa agtagaaggg ctgaaatggt atgaaatcga tgacatatca gatttggaat
     1981 atgcagagaa atatattgtt ccgtattgtt aattaaaata atatatcaaa ttatgagtaa
     2041 gacagtttat attgggatga ctgcggatat tatgcatcca ggacttatcc gcattattaa
     2101 tgaggctact aaatacggtg atgttataat tggtcttctt acagataaag ctattgcgga
     2161 gcataaacgc cttccttatc tgacctatga acaacgaaaa gaggtagttc agaatattaa
     2221 aggcgtatgt aaagttgttc ctcaagaaga atggagctat gttgagaatc tcaaacgcat
     2281 taaacctgac tatataattc atggtgacga ctggaaaacc gggcctttac gtgaagaacg
     2341 tgtgcgcgta tttgaagtga tgaatgaaca gggaggaaag gttatcgaaa ttccatatac
     2401 tttgggaatt aattcatctt ctttggataa agatattaag gctataggta caacccctga
     2461 tgtacgttta aaatcacttc gtcgtttgat aaatgccaaa cccgtagttc gtattttgga
     2521 agctcatgat ggactatgtg gcttgataat tgaaaatcag gaaatattaa aaggggataa
     2581 gagggaagta tttgacggaa tgtggtctag tagccttacg gattcaacca gtaaaggtaa
     2641 acctgatatt gaggcggttg atttaactac ccgattgcaa gatttgaata atattctgga
     2701 gtgtactact aaacctatta tttttgatgg agatacaggt ggtaaaattg aacatttcgt
     2761 atttacagta cgcactttag aacgtcatgg aatttcagct ataataattg aagataaagt
     2821 tggattaaaa aagaattcat tgtttggtac agatgttatt caaactcaag atacaatcga
     2881 aggtttctgt aataagatca aagcaggaaa ggcatctcag attactgatg attttatgat
     2941 tatcgctcgt attgagagcc ttatagcggg aaagccggta agtgatgctt tagagagagc
     3001 ttttgcatat gtccaagcgg gagcggacgg tattatgata catagcaaaa ataagtcggg
     3061 tgaagatata aaagaatttt gtttggcgtt tcgaaaacag tatgctcatg tacctatcgt
     3121 ggttgtgcct actacatatg atcatattta tgagtctgaa ttgtgtgatt ggggtgtgaa
     3181 tataattatt tatgctaatc atatgcttcg tgccgcttat cctgctatga tgaatgtcgc
     3241 aaagataata ttagagaatg aacgtgcttt agaggtgcgc gaactgtgta tgcccataaa
     3301 agaaatattg gaactgattc caggtactaa ataaaaagag gaatatcatt atgttaagcg
     3361 tagaaaaagt ttatgaaacg tttctgagtc atgacgttga tttttttaca ggagttccag
     3421 actcattact aaaaaatatt tgtgcctata tcacagacca tacttcacgt gagaaacata
     3481 tcatagctgc taatgaaggt gcggctgtag gaattgcttc aggttattat atggcatcag
     3541 gtaaggttcc tgtggtttat atgcaaaatt ccggcttggg taatactgtt aatcctctgc
     3601 tgtctcttgc agatgaacaa gtatacagtt ttccaatgct tttgatgatt ggctggcgtg
     3661 gtgaaccggg aacaaaagat gaacctcagc ataaaaaaca gggtgaggta actttagatt
     3721 tgttgaaagc aatgcggatt ccttatataa ttcttgattc aaatgagaat gatgcattta
     3781 ttcagctcca tgatatcata caatcagcaa aaactaagaa tattcctcat gcaataatta
     3841 ttcggaaaga tgtttttggc aaatataaac ttcaaaaaga gttcggatgt aattatcctt
     3901 tatctcgtga ggatgctttg caaatagttg tggattatct gcctgaaaat tcagtggtcg
     3961 tttctactac tggcaagctt tctcgtgagt tatttgaata tcgagaaatg aaagagcaag
     4021 gtcatgaaca tgattttctc acggtaggct ctatgggaca tagttcatca atctctttgg
     4081 gtattgctat agcaaagcaa gatagacctg tttattgctt ggatggtgat ggagcattta
     4141 ttatgcattt aggggcaatt agtaacattg gcgatttatc tcctaaaaac tattatcata
     4201 ttttgtttaa caatggtgct cacgagtctg taggaggaca gcctacttta ggatttagtt
     4261 tagatattcc ggctattgtc cgggggagcg gatataagca tacttatact gtttgtacaa
     4321 aagttgaaat tgaagaagca atgaagcagc ttccaaagtt atgtggtcct gttttgttgg
     4381 aaataaaggt taaaatagat tctcgggaga atttgggacg tcccacgact actcctatag
     4441 agaataagga gcattttatg gattttttaa aataaatata ttcgatgaaa atagaaagaa
     4501 aaatattatt aaatcctggg cctgccacta ctactgacag tgtaaaaatg gcacaagttg
     4561 ttccggatat ttgtcctcgc gagaaagaat tcgcaggtat gatgaaacaa cttcgggacg
     4621 atttggtcag agttgctcat gggaatttgg aaaaacatac cgctgtatta ttttgtggct
     4681 caggaaccat caatattgat atatgtctaa attctcttct tcctgaagac aaaagggtgc
     4741 ttatagtgaa taatggggca tatagtaccc gtgctgtaga agtgtgtcaa tattatggtt
     4801 tgcctcatat taatttggaa ttttccgttt acgaacgtcc tgatttatcg gtggtggaaa
     4861 atgtgttgca agaaaatcct gatatagcta tggtttatac tactcatcac gagacgggta
     4921 caggaattct gaaccctatt cgcgagatgg gcgctatagc tcataaatat caggctaaat
     4981 ttgtcgtcga tactacttct tctttgggca tgattccttt tgatatagag aaagataatg
     5041 tggatttttg tatggcatct gctcaaaaag gacttcaagc gatgacaggt ctttctttta
     5101 ttataggcaa tgaggaacag attaagtttt caaaaaaata tcccaagcgt tcttactatt
     5161 gtaatcttta tttgcagtat gagaattttg agagaacagg tgaaatgcat tttactccac
     5221 cggtacaaac tatttacgcc actcgtcagg cattaaatga atattttgaa gtgggtgaag
     5281 aagctaagtt tgcccgtcac aaaagagttt ttgaggctat tcattcaggt ataaatgaaa
     5341 ttggtcttaa aagtgtaata aagcgtgaat ggcagtcagg actggttgtc tcagttcaat
     5401 acccagaaga tcccaactgg gattttgaga aaatacatga ttattgttat gagcgtggat
     5461 ttacgattta tccaggtaag atatcaactg aggatacttt tagaatctgt gctttaggag
     5521 agatagaagt agatgatatt gagaacttct ttaaagtact aaaagctgca ttaaatcatt
     5581 ataacgtcac attaccgatg tcatgattgc agaaatatta ttgaagattc gtcattttta
     5641 tttttccctt cgtggtatac acttccatcc ggaaagtgtt atttctggag tgcctattcg
     5701 tagctttcgc ttagtaggca aatatggcaa tattaatttg aggtgatgca ttaggagttc
     5761 tttattctta taaaaaggca tcggtagtta taggagataa tgtttgtgta gggtaatttg
     5821 cttttagtgg gagagaccat attagaattg cggtaagggg cgaagaagat aataaccaat
     5881 tagtgagaat attggaaaaa tataattgat atcggtaaat gtagttgttt ttatactgta
     5941 tttaagtaat ggaaaatcta aagcagaaaa ctgtatcagg aataatgtgg agcgctatag
     6001 aacgtttctc tttacaagga gtacagttta taattcaaat aatattagct cgtttgttac
     6061 taccatcgga ttatggtatg atcgggatgt tagctatttt tcttcaagtc gctcaagtat
     6121 ttatagatag cggttttaca aatgctttaa tccagaaaaa agatagaact gaagaggatt
     6181 ttgccactgt cttttatttt aatattcttg tcgcagtatt attctatggt atattgtttt
     6241 tttcggcttc tttgattgca gacttttata atatgccgac tttagttctt gtaattcgtt
     6301 ttatagcatt gtcgttgata ataaatgctt tatcggctat tcacagaacg aaattaatta
     6361 tttctgtaaa ctttaaaact caatctaaaa tttcattagg tgcagctttt atatcaggcg
     6421 tgattggaat atggatggct tatgtcggtt gcggggtttg ggctttagtt tggcaaactc
     6481 tcttaaatag tataattttg acaattttgt tttactgttt agttcattgg aaacctttac
     6541 atactttctc caaaagttct tttgaaagat tattcaattt cggatctaaa ttattgatct
     6601 caagtcttat caatacagta tatcgtaatc tgtataccat tgtaatagga aaaaagtttt
     6661 ctgttgtaga gcttggttac tatacaagag cagaacaatt tgctattttt ccttccaata
     6721 atttaaatgc tttagtttct agagtagcgt atcctatttt aagttccatt caagatgatg
     6781 ataaatgttt aacaaacgca tatcgaaatt atatcagatt atcctcatat ataatttttc
     6841 ctttaatggt aggtttactt gttttggcta atcctattat tagtctattg ttaacagata
     6901 aatggtctgg ggttgttatt cttttacaga tattatgttt ggattggatg tttgatcatt
     6961 tgagccaaat taatttgaat ttattatggg ttaaaggaag atctgatctg tcgttacgtc
     7021 ttgaaataat aaaaaagacg attgctatat tcattctttt tgtgtcaatt ccatttgggc
     7081 ttgaggtgat gtgttggggt agagttattt actctctgat agcgacatat ttgaatacat
     7141 attatactaa ttctcttatt gatttgacct taaagttgca agttaaagat gtatttccaa
     7201 gtttaatact ctctttcata atggggggga tcgtttttat atgtatttct ttctttgaaa
     7261 ctgatatagt aaaaattgtg attggatgta ttactgggat gtccttctat attttacttt
     7321 cttttctttt taagctagat tctttttttt gtattttaac attgatcatt aaaactaaaa
     7381 acatagatga aaatattaaa aaagattttt caagtaatag taaagataat taaccattgt
     7441 gtgccagttg atagtagatc attgtatttt attcctcatc ctaattgtag aacagataaa
     7501 tatgatatta taaattattc gtcagataat gttctcgttc tgttaaatta tttgctaaaa
     7561 aaagatagtg ctgaatatta taaaatatat gttgaaattt atgattcttc tcgtatttca
     7621 gaatatcaag aatatattta tggcataaat cctaatatta ggtgtacttt tttatgtgca
     7681 tgtgttggac gttttttctt taataaagta tcttttaagg atatgttgta tgcctttttt
     7741 tgtttttgta gagcaagtaa atgttttaca gctacttttt attatgattt ttcatttaaa
     7801 aaacgctctc aacagattat ttgtttgggg tattatactc cattcaaaga tgattatcat
     7861 atgggagatc attcttatga taaatttcgt aatacaacat gtaactcatt tgattactct
     7921 attgctactt cttgtttaag tgctagaata atttcaatag attgtggaat ctcatatgat
     7981 aaattcaaag tcttaggatt tcccagaaat gatttgttga tatcgaaaaa taattgcaat
     8041 gttattaaaa gagaaatttc gaaatttgcg ggatatgatg taactaaata tatagtttat
     8101 actccaactt ttcgtgatta tgagactgtt actgaaggta atttgcgttc aatactcgga
     8161 tatgttgatt gtgatttgtt gaagttatcg aaaatactat tgaagtttaa tgcggcttta
     8221 attcttaaat tacatccttt gcagaataaa acagtcttaa aaaaagattt acccaaaggt
     8281 atacttgttt ttgaacaaac atataaatat ggattgtatg atcttttgtc attttcagat
     8341 ggaatgatta ctgattatac ttctacctat tttgattttt tattggtaaa taagccagtc
     8401 atatttaatt tctacgatat tgaagaatat cgtagagtaa gaggtttctc atttgagcca
     8461 atagaatttt tttgtgcagg tgatattgtt tacaattata atgaattgat agatgctgtg
     8521 atgggacttc tggctgggaa agatattcat gctgaacatc gacgtcatat ttctttattg
     8581 atgaatcaat ttcaagatga taattcaaca aagagaatat gtgacatatt tttaaatgaa
     8641 atataataaa taaaatgaat tatgcatttg tggtgcaggc acgtttaggt tctacacgtt
     8701 tgcctggaaa aatattgaaa cctttctatg gtaatcaatc gattcttgac ttaatggttc
     8761 ataagctttc tgctatatcg aatattccag taattattgc tacaacaaat tctgttatca
     8821 atgaacctat tgaaaagaag gcacttgcat taggggtaaa gtgcttcaga ggtgaggaga
     8881 atgatgtttt aaaacgattc attgatgttg ctgaatattt tgatatacag ggtatattcc
     8941 gaatatgttc tgataatcca tttttagatg tacatgcggc aaggcaattg gtcgaaatag
     9001 caatgaaatc ttgtaacgat tatataagtt ttgatattga tggtactcca tcaattaaaa
     9061 ctcatttcgg tttttgggga gaatttgtaa cgcttgatgc gctgaagcga gttataggat
     9121 ttactgatga tttattgtat cgtgaacatg ttactaatta tatatatagt catcctgaac
     9181 tttttaatat tcaatggatt tcaggatctc cagtcgtgtc aaaacatcat aatattcgac
     9241 tcacgattga tacgttagaa gatttttctg tagcacagag aatatatagg gatttacaag
     9301 aaaaaagagt ggaaatatcg atagaagtga ttgtagacta tgttcgaaga catgcagaat
     9361 acattcaact gatgaaacaa caaataaaaa aaaattctaa ataatgaaga atacttatat
     9421 tattggtgaa atagggcaga atcataatgg ttctgttgac ttggctaagt tgattattga
     9481 attaatctca cgacctgtac atgaggatgt ttttggtatg gatttcatgc caatgaatgc
     9541 tgttaaaatg actaaaagag atttatcaga agaattggct gtttctcaaa tgaatcaaat
     9601 atatgacaat cctaattctt ttgggcgtac ttatggtgaa catcgtgctt ttcttgagct
     9661 tgatgatcaa gcgcattttg agatttataa atatgctaag tcattaggat tagattttat
     9721 cgagacgtta tgtgccaaag gatgtctgtc tttgcttaaa ctgttcacac cggataggct
     9781 aaaagttgct agtcgtgatt tgactaactt accattgctt gaagcattag cagaaactca
     9841 tattcctatt atattatcga caggaatggc tggtcaaaga gaacttgaca atgcattaga
     9901 tgtgataacg agatatcata gtaatatagc tattctacat tgtgtatctc agtatccaac
     9961 tcatccaaat aatttgaatc tacgtacaat aacatatttg aagaagcatt acaataagtt
    10021 tgagataggt ttttctgatc atacaatagg tatttctgct gctacagctg ctgtagcgat
    10081 gggagcggaa attatagaaa agcatgtaac aattgatcgg catatgaaag gaacagacca
    10141 gcttggctct ttaggtccag atggggttaa tcgtatgatt cgagatattc gcatagcaga
    10201 gtgttggctt ggtactgaag atctttatat agaaaaaggg gtggagaagt ctaagataaa
    10261 acttgaacgt tctattgcca ctcgaaaata tattccagca ggtagtatta ttcaagagtc
    10321 ggacattcat ttactgagtc ctggtgatgg ttataaatgg atagataaaa aaaatgtaat
    10381 tggtcatttt gctaaacaag atatatcagc gaatgaaata atatatcctg attttattga
    10441 atagatatat tcctactgca acttgtatta cggtatagag tactgcctgc tataagctaa
    10501 gtagtgatta ataaataagg gtaaaatact aaaaaaatga aagagataaa gcttatactt
    10561 acagatattg atggcgtttg gactgatggc ggaatgtttt atgatc
//
