LOCUS       gnlProkkaLCAFPGLM_26   11718 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LCAFPGLM_26.
ACCESSION   gnlProkkaLCAFPGLM_26
VERSION     gnlProkkaLCAFPGLM_26
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 12:54:13
            Original ID  :: gnl|Prokka|LCAFPGLM_26
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11718
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11718
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[2453:6718]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2454..6718
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..11718
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11718
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             147..671
                     /locus_tag="ctg26_1"
                     /transl_table=11
                     /translation="MSEQQKYWFAARTRDKQEFAIRDSLEKLKTELDLNYYLPTQFVIR
                     QLKYRRKRVEVPVIKNLIFIQATKQDACDISNKYNIQLFYMKDLLTRAMLIVPDKQMQD
                     FIFVMDLDPNGVSFDNDHLSVGSRVQVVKGDFCGVEGELASEANKTYVVIRIAGVLSAS
                     VKVPKSYLRVI"
     CDS             675..1160
                     /locus_tag="ctg26_2"
                     /transl_table=11
                     /translation="MNTLTSQIEQLQSLAHELLYLGVDGAPIYTDHFRQLNKEVLEQSD
                     ALYPQRGATPEEEANICLALLMGYNATIYNQGDKEEKKQVVLNRCWDVLDQLPATLLKC
                     QLLTYCYGEVFEEELAKEAHTIIESWSNRELLKAEKEIAESLNNLEANPYPYSELHE"
     CDS             1157..2440
                     /locus_tag="ctg26_3"
                     /transl_table=11
                     /translation="MIRSFLSRSPLYVLALYASVLIFLVYTCAYAYRKPFTAAIYEGEI
                     LWGFDVKILYVLSEIIGYALSKFIGVRILPSMKAGHRIYYIIGLLTFSEVALLGFALLP
                     VPLKVCSIFLSGLPLGMIWGVIFSYIEGRRISEILNVGLSVALIVSSGLVKTLGQFVMD
                     NLHVSEYWMPFTTGLLVYPVMLLCSWLLNQIPAPNEQDIIQRTKRAPMDGKDRRKFLRQ
                     FFWGICMLVVFYGALTVFRELRDSFAADIWKELHIEGAMIFTQTEVPIAAFVLVLMFLI
                     VFVRNNRLALNIIYCIAVTGGSLMVFSTLLYVYGFLSPIWWMILSGLGLYMGYIPFTYL
                     IERLIASLRVVSTAVFIIYLADSFGYLGTTGVFMVKNFVSADISWTVMLMRTALFSGFV
                     SVLSIFAIYCYFKQQLNSLILIPSEIHD"
     CDS             2454..3152
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg26_4"
                     /sec_met_domain="NTP_transf_3 (E-value: 2.4e-13, bitscore:
                     44.4, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAGLGTRFGHYTELVPKGFVEVGGKPMIIRSIETLLSCGIERII
                     LGTGYKKEAYEALQADFPQIETCFSPRYADTNSMYTLYNTRDVIGDDSFLLLESDLVFE
                     RKAILSLLDDEFPDVMLVSSLTKFQDQYYVEYDRNHILTSCSVDKNALEAKGELVGIHK
                     LSNTFYRRMCADYATILESQPKLGYEYELLRMSRSVSPVRVLRVEGLKWYEIDDEADLS
                     YAEEHIIRYC"
     CDS             3172..4473
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 214.1;
                     E-value: 3.9e-65)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg26_5"
                     /sec_met_domain="CTP_transf_like (E-value: 2.6e-11,
                     bitscore: 37.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 1.9e-121, bitscore:
                     398.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 9.5e-64, bitscore:
                     208.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKIYVGMTADIMHPGLIHIIHEATKYGDVIVGLLTDKAIAEHK
                     RLPYLTYDQRKEVVENIKGVFEVVPQEDWSYVPNLEKLKPDYIIHGDDWKTGPLREVRE
                     QVFEVMNAQGGKVIEIPYTRGINSSSLDKDIKAIGTTPDVRLKSLRRLIQAKPVVRILE
                     AHDGLCGLIIENLEVQKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAVIIEDKVGLKKNSLFGTDAIQTQDS
                     IEGFCDKIRAGKNAQVTGDFMIIARIESLIAGKPMSDALERAYAYVQAGADGIMIHSKD
                     KSGEDIREFCRTFRKEYAHVPIVVVPTTYDHVHESELHEWGANVVIYANHLLRAAYPAM
                     MNVARTILENERAEEVRPLCMPIKEILELIPGTK"
     CDS             4485..5621
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 71.8;
                     E-value: 7.9e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg26_6"
                     /sec_met_domain="TPP_enzyme_N (E-value: 3.1e-21, bitscore:
                     69.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 8.3e-20, bitscore:
                     64.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSVEKIYDTFLHHGVDFFTGVPDSLLKNICAYITDHAPRGKHII
                     AANEGSAVGIACGYYMASGNVPLVYMQNSGLGNTVNPLLSLADEKVYSLPLLLLVGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMKIPFIILDTDEDEALAQIHDAVVSAKSRSIPHAIV
                     IRKDTFGKYKLRQEALNDYPLSREEALMQVVDHLGDNDIVVSTTGKLSRELFEYRESKG
                     QGHARDFLTVGSMGHSSSIALGVALEKPDRRVYCLDGDGAFIMHMGAVSNIGDLSPKNY
                     RHVLFNNGAHESVGGQPTLGFRLDIASIAKGCGYAHVLTASDKEGLSCALEKLSGLSGP
                     VLLEIKVRIDSRDDLGRPTTTPVENKEHFMAFLKNTHS"
     CDS             5618..6718
                     /NRPS_PKS="Domain: Aminotran_5 (30-293). E-value: 1.1e-33.
                     Score: 108.5. Matches aSDomain:
                     nrpspksdomains_ctg26_7_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 79.1; E-value:
                     5.2e-24)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg26_7"
                     /sec_met_domain="Aminotran_5 (E-value: 2.7e-30, bitscore:
                     99.2, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIERKILLNPGPATTTDTVKLAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGDLSKHTAVLFCGSGTINIDICLNSLLPADKKVLVVNNGAYSTRAVEVCEYY
                     GLPHIDLKFSVYELPDLSVIEKTLSDNPDIALVYTTHHETGTGILNPIREIGKIAHSHG
                     AVFVVDTTSSLGMIPFDIGKDNVDFCMASAQKGLQAMTGLSFIIGDESLIRASRDYPKR
                     SYYCNLYLQYDYFEKTGEMHFTPPVQTVYAARQALDEYFAVGEETKFARHKRVFEAIHK
                     GLQELGLQYAIKREWQSGLVVSVLYPDDPLWDFDKVHDYCYERGFTIYPGKISTTNTFR
                     LCALGEIDVEDIERFFEVMREAVLKY"
     aSDomain        5708..6496
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg26_7_Aminotran_5.1"
                     /evalue="1.10E-33"
                     /label="ctg26_7_Aminotran_5.1"
                     /locus_tag="ctg26_7"
                     /protein_end="293"
                     /protein_start="30"
                     /score="108.5"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGDLSKHTAVLFCGSGTINIDICL
                     NSLLPADKKVLVVNNGAYSTRAVEVCEYYGLPHIDLKFSVYELPDLSVIEKTLSDNPDI
                     ALVYTTHHETGTGILNPIREIGKIAHSHGAVFVVDTTSSLGMIPFDIGKDNVDFCMASA
                     QKGLQAMTGLSFIIGDESLIRASRDYPKRSYYCNLYLQYDYFEKTGEMHFTPPVQTVYA
                     ARQALDEYFAVGEETKFARHKRVFEAIHKGLQELGLQYAIK"
     CDS             6738..8231
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg26_8"
                     /sec_met_domain="Polysacc_synt (E-value: 6.6e-10, bitscore:
                     32.6, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDKKNVVKWNFVFYLLEFLYTILVGIILVPLYLKYIPKDLYGFW
                     LATGNILSILTLINPGFSDVIQQKVAYCYGLHDYKKIGLYTVSGICLTFVFSLIVLIIG
                     VVVNLLIGSIFTMQANYLYELKIAFGLMLVGTFLTINYYSFSSILYAFLNSKSIGLIVL
                     LGNSLGTLISIYLIIHGYGLIALGIASVVRGGVFLSCSVGYVIFKFRKKKIKIVFDLNN
                     VKEVFSFSIYNFLGKTGQTLLTNMNSFLTAKFVSPIDAANLRFTQTVPEFGKVLVLRFL
                     YSVAPIIPNLLAAKGLESIRIKLLNIVYFLISFIFLVCIGFYLLNEQFIYLWLGENNFS
                     GKIINFFIIILLFFSSINKVCFQFLFALGDIKKSNKILFYQSLLYLPIAVFTTKFCGII
                     GLLLSGILVELLALFIFFFPKMVDILNISKIDIRKKLFVELTKISFVTVITLLIGSCVK
                     FSNPSWLLFFVEIVFIVLTFFVLLFLCSKTFRNLLSICK"
     CDS             8235..9380
                     /locus_tag="ctg26_9"
                     /transl_table=11
                     /translation="MKILLVFIDMIRVDHLSLYNDNMEKTSLDLFFENLGGTILTNCYT
                     PAPDTPRSIACLQSGLLPYLNGCDSRVKWPRYFMKPNIETIFDIAVGLGYKVNLCATKS
                     DIETGLFKFKENENISIFTTIEDFTDTVHLSENTLSLIAIDDYHSAIDDYGGTSLGIKE
                     GQKVILYSLNNFLTPDIVNKYDYSFFFSDHGHALQSEIVMQKNKLELLSDGRTKLFMFY
                     HNINNKKIVKDSRLASILDLYASIVDLIGSGDFRQGFSFFRDSQRDILHIEDHADFRVS
                     PEQIVSQWRVISDEIDIRTNVFETLNKKGQIIDINVVKKYLDSFSPSFSYYMKQIEILK
                     MYEKMKQRKTHYFNGVKRANWWIRCYVRIINRLYILINRLK"
     CDS             9377..10246
                     /locus_tag="ctg26_10"
                     /transl_table=11
                     /translation="MIVSSLRGGLGNQMFIYAMVKAMALRNNVPFAFNLTTDFANDEVY
                     KRKLLLSYFALDLPENKKLTFDFSYGNYYRRLSRNLGCHILHPSYRYICEERPPHFESR
                     LISSKITNAFLEGYWQSEKYFLDYKQEIKEDFVIQKKLEYTSYLELEEIKLLDKNAIMI
                     GVRRYQESDVAPGGVLEDDYYKCAMDIMASKVTSPVFFCFSQDLEWVEKHLAGKYPVRL
                     ISKKEDDSGTIDDMFLMMHFRNYIISNSSFYWWGAWLSKYDDKLVIAPGNFINKDSVPE
                     SWFKLNVR"
     CDS             10254..11306
                     /NRPS_PKS="Domain: NAD_binding_4 (4-199). E-value: 8.1e-12.
                     Score: 36.6. Matches aSDomain:
                     nrpspksdomains_ctg26_11_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     300.7; E-value: 2.1e-91)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg26_11"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.3e-16, bitscore:
                     53.4, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 2.1e-13,
                     bitscore: 43.7, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVLVTGAAGFIGSHVCKRLLQRGDEVVGLDNINSYYDINLKYGR
                     LSSLGVSQSELSWYKFTRSNVYPRFSFVRMNLEDRQAMQMLFANGNFDVVINLAAQAGV
                     RYSIENPYAYVESNIDGFLNVLEGCRHSQVKHLVYASSSSVYGLNGQVPFSEKDGIAHP
                     VSLYAATKKSNELMAHTYSHLYNIPSTGLRFFTVYGPWGRPDMSPFLFADAILHGRPIK
                     VFNNGNMLRDFTYIDDIVEGVLRVADSIPEGNQCWDAEVADPSMSCAPYKIYNIGNSRP
                     VKLMDFIRAIEMSIGREADKIYLPMQPGDVYQTYADTSSLSREIGFQPNTSLEAGVKKT
                     ISWYKEFYNL"
     CDS_motif       10263..10325
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg26_11_0001"
                     /evalue="2.20E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg26_11"
                     /protein_end="24"
                     /protein_start="3"
                     /score="13.9"
                     /tool="antismash"
                     /translation="LVTGAAGFIGSHVCKRLLQRG"
     aSDomain        10266..10850
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg26_11_NAD_binding_4.1"
                     /evalue="8.10E-12"
                     /label="ctg26_11_NAD_binding_4.1"
                     /locus_tag="ctg26_11"
                     /protein_end="199"
                     /protein_start="4"
                     /score="36.6"
                     /tool="antismash"
                     /translation="VTGAAGFIGSHVCKRLLQRGDEVVGLDNINSYYDINLKYGRLSSL
                     GVSQSELSWYKFTRSNVYPRFSFVRMNLEDRQAMQMLFANGNFDVVINLAAQAGVRYSI
                     ENPYAYVESNIDGFLNVLEGCRHSQVKHLVYASSSSVYGLNGQVPFSEKDGIAHPVSLY
                     AATKKSNELMAHTYSHLYNIPSTGLRFFTVYG"
ORIGIN
        1 acgaacgttt tttgaaacac attcgttcgt tctcaacttc taaaaatgtt tcgtaaaatt
       61 tgacggtttg aaagagaaaa gatgtctcgt tcaaaccgcg aagcgcaccc gaaacaaagg
      121 aaaatttccc caagtataaa tcgtaaatgt ctgaacaaca gaagtattgg tttgccgccc
      181 gtacccgaga taaacaagag tttgctattc gtgactctct tgaaaaattg aagactgaac
      241 ttgatctcaa ttactatctt cccactcagt ttgtcatccg gcagttgaaa tatcgtcgaa
      301 aacgggtgga agtccctgtt attaagaatc ttatcttcat ccaagctacc aagcaagatg
      361 cttgtgatat ttctaataaa tacaatatcc agctttttta tatgaaagac ctgcttacca
      421 gggctatgct gatagttcct gataaacaga tgcaggactt catatttgtc atggatttag
      481 atccgaatgg cgtcagtttc gataatgacc atttatctgt cggtagcagg gttcaggtag
      541 ttaaaggtga tttctgtggt gtcgagggcg aacttgccag cgaggccaac aaaacttatg
      601 ttgttattcg tattgccggt gtattgagcg ccagcgtcaa agttcctaaa agttatttac
      661 gtgtcattta agttatgaat acactcactt ctcaaattga acaattacag agtctcgcgc
      721 acgagttact ctatttaggt gtggatggtg ctcctattta taccgatcat ttccgtcagt
      781 tgaacaaaga agttttagaa caatccgatg cgttgtatcc tcagcgtggt gctactcccg
      841 aagaggaagc aaacatctgt ctggcattat tgatgggtta caatgcaacc atctataatc
      901 agggtgacaa ggaggagaaa aagcaagttg ttctcaatcg ttgttgggac gtgcttgacc
      961 aacttcctgc tactttattg aaatgccagt tgttgactta ttgttatggt gaggtgtttg
     1021 aagaggagtt ggcgaaagag gcgcatacta tcatagaaag ttggagcaat cgagaacttt
     1081 taaaagctga aaaagaaata gctgaaagtt tgaataattt ggaagctaat ccatatccgt
     1141 acagcgaact acacgaatga ttcgttcctt tctttcccgt tctccccttt acgttttggc
     1201 tctctatgcc agcgttttga tttttctggt ttatacttgt gcctatgcct accgtaagcc
     1261 atttaccgca gccatttatg aaggtgagat tctttgggga ttcgatgtca aaatcctgta
     1321 tgtcctttct gagattatcg gctacgccct ttccaagttc atcggtgttc gtattctgcc
     1381 ttcgatgaaa gcgggtcacc gcatctatta tataataggg ctgcttactt tttccgaagt
     1441 tgctttgttg ggttttgcac ttcttccggt tcctttgaag gtgtgttcta tttttctgag
     1501 cggtcttccc ctgggtatga tctggggtgt catttttagc tatatcgaag gacgtcgtat
     1561 cagtgaaata ttgaatgtcg ggctgagcgt tgctttgata gtctcttccg gtttggtgaa
     1621 aaccttggga caattcgtga tggataattt gcatgtgtcg gaatattgga tgccttttac
     1681 caccggtttg ttggtatacc ctgttatgtt gctttgcagc tggcttctca atcagattcc
     1741 ggctcccaat gagcaagata tcatacagcg taccaaacgt gctccgatgg atggtaaaga
     1801 caggcgtaag tttttgaggc aattcttctg gggaatctgc atgctggttg ttttttacgg
     1861 tgccctgacc gtgttccgtg agcttcgtga ctctttcgct gccgatattt ggaaggagct
     1921 ccatattgag ggtgcaatga tctttactca gacagaggtt cccattgccg cttttgtcct
     1981 tgtactgatg ttcctgattg tgtttgttcg taataaccgt ttggctctta atatcattta
     2041 ttgcattgcc gtcacaggcg gttccttaat ggttttttcc acattgcttt atgtgtacgg
     2101 ttttctttct cctatttggt ggatgattct ttccggtctt ggtctgtata tggggtatat
     2161 tcctttcact tacctgatag aacgcctgat tgcttccctt agggtggtta gtacggctgt
     2221 ttttattatt tatttggccg attctttcgg ctatctgggc actacgggtg tgtttatggt
     2281 caagaacttc gtttctgctg acatttcctg gactgtcatg ctaatgcgta ctgccctttt
     2341 ttcaggattt gtttctgtcc tgtcgatttt tgcgatttac tgttatttca agcaacaatt
     2401 gaattcactt atattaattc cctctgaaat tcatgattaa aacagcaatg atcatggctg
     2461 ccggtcttgg tacccgcttc gggcattata ccgagcttgt gcccaaaggt tttgtggagg
     2521 ttggtggaaa acctatgatt atccgctcta tcgaaaccct tctttcctgc ggtatcgaac
     2581 gtatcatcct cggtacgggt tataaaaaag aggcttatga agcccttcag gcggatttcc
     2641 cccagataga gacctgtttc agtccccgtt atgccgatac taacagtatg tacactctgt
     2701 acaatacgcg tgacgtgata ggcgatgaca gtttcctgct gcttgaatcg gaccttgttt
     2761 ttgaacgcaa ggccattctc tcgctactgg atgacgaatt cccggatgtg atgcttgtct
     2821 cttctctgac caagttccag gatcagtatt atgtggaata tgaccgcaat cacatcctta
     2881 cttcctgttc ggtagacaag aacgcccttg aggcaaaagg cgagctggtc ggtatccata
     2941 aactttccaa tactttctac cgccggatgt gcgccgatta tgcgaccatc ctggagtccc
     3001 agcctaaact gggttacgag tacgaactgc tccgcatgtc ccgttccgtt tcccctgtcc
     3061 gtgtgctcag ggtggagggt cttaaatggt atgaaatcga tgatgaagcc gacctttcgt
     3121 atgccgagga gcacatcatc cgctattgtt aaaaacaaat cttttccata tatgaacaag
     3181 aaaatctatg tcggtatgac cgcggatatc atgcatccgg ggctgatcca tattattcat
     3241 gaagctacta aatacggtga tgtcatcgtc ggtctgctga cggacaaggc catcgccgaa
     3301 cacaaacgcc tcccttacct tacctatgat cagcgtaagg aggttgttga gaatatcaag
     3361 ggggtttttg aggttgttcc ccaggaggac tggagctatg ttccgaatct ggaaaaactc
     3421 aagcctgact atatcatcca cggcgacgac tggaaaacgg gcccgttgcg cgaggtgcgc
     3481 gaacaggttt ttgaggtgat gaacgcccag gggggcaagg taatcgagat cccttatacc
     3541 cggggcatca actcctcctc gctcgacaag gatatcaagg cgatcgggac tacccctgac
     3601 gtacgtctta agtccctccg ccgcctgatc caggccaagc ctgtggtccg tatcctggag
     3661 gctcacgacg gtctttgcgg tctgattatt gagaatcttg aagtccagaa gggtgataag
     3721 cgcgaggtct ttgacggcat gtggtccagc agcctgaccg actccacgag taagggtaaa
     3781 ccggatattg aagcggtcga ccttaccacc cgtttacagg acctgaacaa tatccttgaa
     3841 tgcaccacca agcctattat ttttgatgga gacacgggtg gcaagatcga acactttgtc
     3901 tttactgtgc gcactctgga acgtcacggc atttctgcgg taatcattga agataaagtc
     3961 ggtctgaaga agaattccct ttttggtact gacgctatcc agactcagga tagtatcgag
     4021 ggtttctgcg ataagatcag agcagggaag aatgcccagg tcaccggtga ctttatgatc
     4081 attgcgcgta tcgaaagcct tattgccggc aaacccatga gtgacgccct cgaacgtgct
     4141 tatgcctatg tacaggcggg tgcggacggc atcatgatcc acagcaagga taagtcgggt
     4201 gaggatatcc gtgagttctg ccggactttc cgcaaagaat acgcccatgt tcccattgtc
     4261 gttgttccga cgacttatga ccatgtgcac gaatccgaac ttcacgaatg gggtgccaac
     4321 gtagtcattt acgccaacca ccttctccgt gccgcttacc cggccatgat gaacgtggcc
     4381 aggaccatcc ttgaaaacga gcgcgccgag gaggtccgtc cgctttgtat gcctatcaag
     4441 gaaattctgg aattgattcc gggcactaaa taaatcagac ggttatggta agtgtagaaa
     4501 agatatacga tacgttcctt catcacggtg ttgacttctt tacgggtgtt cccgattccc
     4561 ttttgaagaa tatttgcgcc tatatcacgg atcatgctcc gcgtggtaag catatcatcg
     4621 ccgccaatga aggttccgcg gtgggcattg cctgcggtta ttatatggct tctggcaacg
     4681 ttcctttggt ttatatgcag aactccggtc tgggaaatac ggtgaatccc ctcttgtccc
     4741 ttgcggacga gaaagtgtac agccttcctc ttcttttgct ggtcggctgg cgcggtgagc
     4801 ccggcacgaa agacgaaccc cagcataaga agcagggcga ggttaccctt gatcttctga
     4861 aagccatgaa aattcctttt ataattctgg atacggatga agacgaggcc ctggcgcaga
     4921 tccatgacgc ggttgtctcg gcgaagagcc ggtcgattcc ccatgcgatt gtcatccgta
     4981 aagatacgtt tggaaaatat aaattgcgtc aggaagcctt gaatgactat cctctgtccc
     5041 gcgaggaggc gctaatgcag gttgtcgacc acctcgggga caatgacatt gtggtttcca
     5101 ccacgggcaa gctctcccgt gagcttttcg agtaccgtga atcgaaaggg caggggcacg
     5161 caagggattt cctaactgtg ggttccatgg ggcacagttc ttccattgcc ctgggggttg
     5221 cccttgagaa gcctgaccgc cgtgtctact gtcttgacgg tgacggtgcc tttatcatgc
     5281 acatgggtgc tgtcagcaat atcggcgatc tttctcccaa gaattacagg cacgtccttt
     5341 tcaacaacgg tgcccatgaa tctgtcggcg gtcaacccac gctcggtttc cgtctggata
     5401 tcgcctcgat agcgaaaggt tgcggttatg cgcatgtact gactgcctcc gacaaggaag
     5461 ggctttcgtg tgcgcttgag aagctgtccg gcctgtccgg cccggttctt cttgaaatta
     5521 aggtccggat cgattcacgt gatgatctgg gtcgccctac gactactccg gtagagaata
     5581 aagagcattt tatggcattt ttaaaaaata cgcattcatg aatatcgaaa gaaagatcct
     5641 tttgaatccg ggtcccgcca ccacgacgga tacggtgaag ctggcgcagg ttgttcccga
     5701 tatctgtccg cgtgagaaag agtttgcggg tatgatgaaa cagttacgtg acgacctggt
     5761 ccgcgttgcg catggagacc tctccaaaca tacggccgtc ctgttttgcg gctcgggtac
     5821 gatcaatatc gatatctgcc tgaactctct tcttcctgcg gataagaaag ttctggttgt
     5881 caataacggt gcctacagca cccgtgcggt ggaagtctgc gaatattacg gtcttcccca
     5941 tatcgatttg aagttttccg tttacgaact tcccgacctg tcggtaatcg aaaagacgct
     6001 ttccgacaat ccggacatcg ctttggtcta taccacgcac catgaaacgg gtacgggtat
     6061 cttgaacccc atccgtgaga tcggaaaaat agcccattcg cacggtgccg tttttgttgt
     6121 cgacaccact tcctccctgg gtatgattcc ttttgatatc gggaaggata atgttgactt
     6181 ttgtatggct tcggctcaga aaggccttca ggccatgacg gggctttcct ttatcatagg
     6241 tgatgaatcc ctgatacgtg cttcaaggga ttatccgaaa cgttcctact attgtaacct
     6301 ctatttacaa tacgattact ttgagaagac gggcgagatg cattttactc ctcctgttca
     6361 aaccgtttac gctgcccgtc aggctcttga tgaatatttt gcagtaggtg aagagactaa
     6421 attcgcccgt cacaagaggg tctttgaagc catccataaa ggtttgcaag agcttggtct
     6481 tcagtatgcg atcaaacgtg aatggcagtc gggtcttgtt gtttctgtat tgtatcctga
     6541 tgatcccctc tgggattttg ataaggttca tgattactgc tatgaacgtg gctttacgat
     6601 ctacccgggt aagatttcca caacgaatac attccggctt tgtgcgttgg gagagattga
     6661 tgtggaggat attgagaggt tctttgaggt gatgagagag gctgttttaa aatactagag
     6721 aaattgtcaa ttgggatatg aaagataaaa aaaatgtagt aaaatggaat tttgtatttt
     6781 atctcttgga atttttgtat acaattttag ttgggattat tttggttccg ttgtatttga
     6841 aatatattcc aaaggattta tatggtttct ggctagctac tggtaatata ttgtctattt
     6901 taactcttat caatcctggg ttttcagatg tgatacaaca aaaagttgca tattgttatg
     6961 gattacatga ttataaaaaa ataggattat ataccgtttc aggtatttgt cttacgtttg
     7021 ttttttcatt aattgttttg ataatcggag tagtagttaa ccttttaata ggtagtatat
     7081 ttacaatgca agctaattat ttatatgaat taaaaatagc ttttggctta atgcttgttg
     7141 gtacattttt aactattaat tattattcct tttcttctat attatatgct tttcttaata
     7201 gtaagtcaat cgggctaatt gtacttctag gcaatagttt aggtacttta atatctattt
     7261 atcttattat ccatggatat ggtctaatag ctttgggaat tgcatcagtt gttcgaggag
     7321 gtgttttttt gtcatgtagt gttggctatg taatatttaa atttcgaaaa aagaaaataa
     7381 aaattgtatt tgatttaaat aatgttaagg aggtcttttc tttttctata tataattttt
     7441 taggtaaaac aggacaaaca ttgttgacta atatgaattc tttcttgact gctaagtttg
     7501 tttctcctat tgacgctgca aatttgagat ttactcaaac tgtgccggaa tttggtaaag
     7561 ttttagtttt aagattttta tattctgttg ctcctattat tcctaatttg ttagcagcta
     7621 aggggttgga gtctattaga ataaagcttt tgaatattgt gtattttttg atttccttta
     7681 ttttcttagt atgtattggt ttttatctat tgaatgaaca atttatatat ttatggcttg
     7741 gtgagaacaa tttttcaggg aaaataatta atttttttat cattatttta ttgttttttt
     7801 cttctataaa caaggtctgt tttcagtttc tttttgcatt aggagatata aagaaaagca
     7861 ataagatttt attttaccaa tctttgttgt atttacctat tgctgttttt acaacgaaat
     7921 tttgtggaat aattggttta ttgttatctg gaatattagt agaattattg gcactattca
     7981 ttttcttctt tcctaaaatg gttgatattc ttaatatttc gaaaatagat attagaaaga
     8041 aactttttgt ggagttaacc aaaatatctt ttgttacggt tattacatta ttaataggtt
     8101 cttgtgtcaa gttctctaat cctagttggc tacttttctt tgtggaaatt gtttttattg
     8161 tattaacatt ttttgttttg ttgtttttat gttcaaagac ttttcgtaat ttattgtcta
     8221 tttgtaaata aaagatgaag atactactag tttttataga tatgatacgt gttgatcatt
     8281 tatcattata taatgataac atggagaaaa catcgttgga tttgtttttt gaaaatttag
     8341 gaggtacaat tctaactaac tgttatacac ctgcacctga tactccaaga agtatagctt
     8401 gtttgcaaag tggcctatta ccctatttga atggctgcga tagtcgtgtc aaatggccaa
     8461 gatattttat gaaacctaat atagaaacta tttttgatat tgcagtaggg ttaggatata
     8521 aagtaaattt gtgtgcgact aaatctgata ttgaaacagg gttgtttaag tttaaagaaa
     8581 atgaaaatat tagtatattt actactattg aagattttac tgatactgtt catttgtcag
     8641 aaaatacatt gtccttaatt gccattgatg attatcattc tgccattgat gattatggag
     8701 gaacctcatt gggaattaaa gaagggcaga aagtgatatt atattcttta aataattttc
     8761 taactccaga tatcgtaaat aaatacgact attcgttttt cttttcagac catgggcatg
     8821 ctttgcagag tgaaattgtc atgcaaaaaa ataaactaga actacttagt gatggaagaa
     8881 ctaaactttt tatgttctat cataatatta ataataagaa aatagtaaaa gattctaggc
     8941 ttgcttctat tttggatctt tatgcctcta ttgttgattt gattggtagt ggagatttta
     9001 ggcaaggttt ttcctttttt agagacagtc aaagagatat acttcatata gaggaccatg
     9061 ctgattttag ggtgtctcca gagcaaattg tgagtcaatg gcgagtaatt tcagatgaaa
     9121 tagatattag gactaatgta tttgaaactt taaataaaaa aggacaaata atcgatataa
     9181 atgtggtaaa aaaatattta gatagttttt ccccctcgtt ttcttattat atgaaacaga
     9241 tagagattct aaaaatgtat gagaaaatga aacaacggaa aacgcattat tttaatgggg
     9301 taaagcgagc taattggtgg atccgctgtt atgttagaat tataaatagg ttatatatac
     9361 taataaatag attgaaatga ttgtatcatc tttgcgagga ggattgggga atcaaatgtt
     9421 tatttacgct atggtgaagg ccatggcatt aagaaacaat gtaccattcg cttttaattt
     9481 gactactgat tttgcaaatg atgaagttta taaaaggaaa cttttattat catattttgc
     9541 attagacttg cctgaaaata aaaaattaac atttgatttt tcatatggga attattatag
     9601 aaggctaagt cgtaatttag gttgtcatat acttcatcca tcatatcgtt atatttgcga
     9661 agagcgccct ccccactttg aatcaaggtt aattagttct aagattacaa atgcttttct
     9721 ggaaggatat tggcagtcag aaaaatattt tcttgattat aaacaagaga taaaagagga
     9781 ctttgtaata caaaaaaaat tagaatacac atcgtatttg gaattggaag aaataaaatt
     9841 gctagataag aatgccataa tgattggggt tagacggtat caggaaagtg atgtagctcc
     9901 tggtggagtg ttagaagatg attactataa atgtgctatg gatattatgg catcaaaagt
     9961 tacttctcct gttttctttt gtttttcaca agatttagaa tgggttgaaa aacatctagc
    10021 gggaaaatat cctgttcgtt tgataagtaa aaaggaggat gatagtggta ctatagatga
    10081 tatgtttcta atgatgcatt ttcgtaatta tataatatcg aatagctctt tttactggtg
    10141 gggagcatgg ctttcgaaat atgatgataa gctggtgatt gctccaggta attttataaa
    10201 taaggattct gtaccagaat cttggtttaa attgaatgta agataaaatc ttaatgaatg
    10261 tattagtaac cggtgctgcc ggatttatag gttcgcatgt ttgtaagcgt cttttgcaac
    10321 gtggggatga agttgtgggc ttggataata ttaattcgta ttatgatatt aatttaaagt
    10381 atggacgcct ttcgagctta ggtgtttctc aatctgaact gtcatggtat aagttcacac
    10441 ggagtaatgt ttatcctcga tttagttttg tgcggatgaa cctcgaggat aggcaggcta
    10501 tgcaaatgct gtttgctaat ggaaattttg atgtagtaat caatttggcc gcacaagcgg
    10561 gagtgcgcta ctccattgag aatccatatg cttatgttga aagtaatata gacggttttc
    10621 tgaatgttct cgagggttgt cgtcacagtc aggtgaaaca tttggtttat gccagttcca
    10681 gtagtgtata tggtttgaat ggacaggttc ctttttcaga gaaagatggc atagcccatc
    10741 cggtgagtct gtatgccgca accaagaagt cgaatgaact tatggcacat acttatagcc
    10801 atttatataa tataccttct acgggtcttc gtttcttcac ggtatatggt ccctggggta
    10861 gaccggatat gtctcctttt ctatttgcgg atgctatctt gcatggtcgc cccatcaagg
    10921 tctttaacaa tggcaacatg cttcgtgatt ttacatatat agatgacatt gtggaaggtg
    10981 tcttgagagt ggctgattct attccggaag ggaatcagtg ctgggatgct gaggttgcgg
    11041 atccaagcat gtcctgtgct ccctataaga tttataatat tggtaattcc cgtcctgtaa
    11101 aattgatgga ttttatacgt gctatagaaa tgtcaatcgg gagggaagct gacaagatct
    11161 atcttccgat gcagcccggg gatgtgtatc agacctatgc ggatacttct tctctttcgc
    11221 gggaaattgg ttttcaaccc aatacgtcct tggaggcggg cgttaagaaa acaataagtt
    11281 ggtataaaga attttataat ctataattat gaagattgct atagttggta caggttacgt
    11341 cggtttggtt acaggtacct gtttctctga gatgggagta gacgtcacat gcgttgatgt
    11401 gattgaatct aaaattgata atcttaaaaa aggcataatt ccgatctatg agccgggact
    11461 tgaagacatg gtgcaccgca attacaatgc ggggcgtttg aagttcacta cttccttagc
    11521 ctcatgtttg aatgatgttg aggttgtgtt tagtgcagtt ggtactcctc ctgatgaaga
    11581 tggcagtgcg gatttaaagt atgtgcttga agttgcccgt acgattggta aaacgatgaa
    11641 ccattatgta ctggtggtaa cgaagagtac tgttcctgtc ggcacagcgc aacaggtgaa
    11701 agctacgatc cggggtga
//
