LOCUS       c00194_gnlPro..        10645 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AIGJNPKI_194.
ACCESSION   c00194_gnlPro..
VERSION     c00194_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 17:08:53
            Original ID  :: gnl|Prokka|AIGJNPKI_194
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10645
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10645
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2:4022](-)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      complement(3..4022)
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..10645
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..10645
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             complement(3..4022)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg194_1"
                     /sec_met_domain="HGD-D (E-value: 4.5e-29, bitscore: 91.0,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 7.9e-36, bitscore:
                     112.7, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKIGIDVGSTTAKLVAVDENDNLLFSKYERHNAKAKETILSFLK
                     ELLSEIGDKDISVRITGSIGMGISEKCSLPFVQEVVAAAKAIQKDYSHVTSMIDIGGED
                     AKVVFFKDAEATDLRMNGNCAGGTGAFIDQMAIILGVNIDELNQLAMNATQVYPIASRC
                     GVFCKTDIQNLIAKNVSRENIAASIFRAVAVQTVVTLAHGCDITTPVLFCGGPLTFIPA
                     LRKAFIDYLSLDEKEIILPANGTLLPALGAALFHLDKEDYCKLSHLIDKIDTTLNGNGN
                     LASTGLEPVFASNEEYEAWKERISRHKMISSGLKAGTQDVFIGIDSGSTTTKIVVLDED
                     SRLLYSYYNINGGNPIKAVEEGLNQLNDECLKQNAVLNIKGSCSTGYGEDLIRSAFQLH
                     SGIIETIAHYMAAHYLNKDVSFILDIGGQDMKVIFVNNGVIDRMEINEACSSGCGSFLE
                     TFAKSLGYSAQEFSLAACHSEAPCDLGTRCTVFMNSKVKQVLREGATINDIAAGLAYSV
                     VKNCLYKVLKLKDISVLGKDIVVQGGTMRNDAVVRAIELLSGAEVARCDTPELMGAFGC
                     ALYAMKHQGESVSLDEIINKAQYSARSLYCKSCDNRCLVIRYEFESGKSYYSGNRCEKV
                     FTNGESSNRKGLNVYRQKEELLFHRSAEIAAPEQIIGIPRCLNMYEEYPFWHTLFTSCG
                     IQVCLSDPSNFRKYEHNARMVMSDNICFPAKLVHSHVQDLIEKKVDRIFMPFVIFERKG
                     MEQNSYNCPIVTGYSEVIKSVQSEGISVDSPAITFKDRNLLFKQCREYLSGLSVDDRTI
                     QQAFQKAESEQHSFINTLVDYNKNILQQTGKGETLTVMLAGRPYHTDSLIQHKVSDMLS
                     DMGVNVITDDLVRQMDIPTGDAHFVAQWAYTNRILKAAKWCATQGKNIQFVEMTSFGCG
                     PDAFLVDEVRDLLMRHNKSLTLLKLDDINNIGSMKLRVRSMIESLKLANADGTEGDVKD
                     FTTVPVYDKSYRDRKILVPYFTPFISPLIPAIMKVAGYDAENLPLSDNDSSEWGLKYAN
                     NEVCYPATLIVGDIIKALKSGKYDISKIAVAITQTGGQCRASNYISLIKKALVDAGYTD
                     IPVISISVGSDIDNDQPAFKVNWMKVVPITFHAVLYSDCIAKFYYASVVREKEAGASAK
                     LRDKYLQLAPEVILRRNIKGLNSLLQSAITEFNEVCRAVDTPKVGIVGEIFLKFNPFAQ
                     KEIIDWLIGRKIEVVPPILADFFMQGFVNRKVNTDSYIKNRQLPEFIYDWIYKFVKKQI
                     DKINETASKFRYFAPFNDIFEEAEGAKSVISLNAQFGEGWLLPAEIVSYARQGVNN"
     CDS             complement(4142..5596)
                     /locus_tag="ctg194_2"
                     /transl_table=11
                     /translation="VELSGIEDRIVRLTPNSSDLGSAILSKDGENLYYFSAFEEGYDLW
                     KMNLREKGTKRLHKLNSGWSSLMLDKKGDIFLLGSRNMQKMDAKSDALKPISYQAEMKM
                     DLAAEREAMFDHVYKQHQKRFYNLNMHGVDWDAMTAAYRKFLPHIDNNYDFAELLSEWL
                     GELNVSHTGGRYSPRGNGDVTSNLGLLFDWNYLGKGMQIAEIVEKGPFDHSRTKVKAGC
                     IIEKINGEEITPDKDITDLLNNKAGKKTLVSLYNPQNKERWEEVVKPVTSGQLNGLLYK
                     RWVKQRAEDVEKWSGGRLGYVHIQSMGDGSFRTVYSDILGKYNNCDGIVIDTRFNGGGR
                     LHEDIEILFSGQKYFTQVVRGREACDMPSRRWNKPSIMLQCEANYSNAHGTPWVYKHQN
                     IGKLVGMPVPGTMTSVSWETLQDPSLVFGIPIIGYRLPDGSYLENTQLEPDIKVANSPE
                     TVVKGEDTQLKMAVDELLKEIDSRKK"
     CDS             complement(5577..7475)
                     /locus_tag="ctg194_3"
                     /transl_table=11
                     /translation="MKKIIISLALVLTALSSYAITPLWMRDARISPDGKEIVFCYKGDI
                     YKVPVQGGTATQLTTQASYEANPVWSPDGKQIAFASDRNGNFDLFIMSADGGTARRLTY
                     HSASEIPSAFTPDGKFVLFSASIQDPAESALFPTGAMTELYKVPVTGGRTEQVLATPAE
                     WVCFDKSGKNFLYQDRKGFEDEWRKHHTSSITRDVWLYDASTGKHTNLTNREGEDRNPV
                     YAPDGNSVYFLSERNGGSFNVYNFALNTPQEVKAITTFRTHPVRFLSISDKGTLCYTYD
                     GELYTQEPNARPKKVNVDLVRDDEKEIATLRFSQGATSASVSPDGKQVAFIVRGDVFVT
                     STDYATTKQITNTPAKESGVSFAPDNRTLVYASERTGNWQLYTAKIARKEEANFPNATL
                     IEEEVLLPSKTVERAYPQYSPDGKELAFIEDRNRLMVLNLKTKKVRQVTDGSTWYNTGG
                     GFDYEWSPDGKWFTLEFIGNRHDPYSDIGIVSAQGGTITNLTNSGYISGSPRWVLDGNA
                     ILFQTERYGMRAHASWGSQQDVMLVFLNQDAYDRYRLSKEDFELLKEFEKEQKKAKEKD
                     GDKKKDGSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQGRQERYCCGTQRY"
     CDS             complement(7543..8469)
                     /locus_tag="ctg194_4"
                     /transl_table=11
                     /translation="MNFKDCIDSYPFILMEGALGERLKREFDLDISGTVAMADLVYQQK
                     GRLALETLWNEYIDIAYRYQLPFLATTPTRRANKERIYMAGYNESIIADNVDFLRSIKE
                     AANVDMYIGGLMGCKGDAYTGEEALNLEEAIDFHSWQAGLFKSAKVDFLYAGIMPVLTE
                     AIGMAVAMSDTDIPYIISFTIQRDGKLIDGHTIDDAIHCIDNHVSNKPVCYMTNCVHPD
                     IVYEALSHKFNQTQTVKSRFWGIQANTSQLSYKELDGANHLHTSSATDLSEAILKLKSD
                     CHLKIFGGCCGTDSSHMEKIAKISEVT"
     CDS             complement(8512..9333)
                     /locus_tag="ctg194_5"
                     /transl_table=11
                     /translation="MNYKITTLVENCVYGRKLQAEHGLSLYIETPENRLLFDTGASDLF
                     IRNARLLNIDLQKVDYLVLSHGHSDHTGGLRHFLELNAEATVVCKREVFFPKFKDEREN
                     GMKYTRSLDLSRFRFIDELTELVPGVFLFPSVDIIDRKDTHFERFWIQKEDGSRVPDTF
                     PDELAMVLVEPEGLSILSACSHRGITNILRTVRTAFPELPCNLLLGGFHIHNAEESKYQ
                     VIADYLHEYLPQKIGVCHCTGVDKYAFFYKDFGDRIFYNHTGKLIQTDSLL"
     CDS             9547..10092
                     /locus_tag="ctg194_6"
                     /transl_table=11
                     /translation="MEKEAKGKVNTVQIQYYQSPCGKLILGSFENKLCMCDWVVSEERR
                     ATIDKRIQKALNAQYAIENSEVITQTISQLDEYFSRQRTTFDIPLLLVGTEFQKSVWNE
                     LLNIPYGTTISYAQLSQRLDNPKAIRAVASSNGANSISILIPCHRVIGSDHKLTGYAGG
                     LVAKKTLLELESNERRLL"
     CDS             complement(10288..10644)
                     /locus_tag="ctg194_7"
                     /transl_table=11
                     /translation="CPQKDDAAEIVEKMIAADVIVMATPVYFYTMCGQMKIMIDRCCAR
                     YTEITNKEFYFIIAAAENDKGMMERTIDGFRGFLDCLENPQEKGVIYGIGAWKVGEIKD
                     TPYMQEAYEMGKMV"
ORIGIN
        1 acattgttca ccccttgccg ggcgtaagac acgatttcag ccggcaacaa ccagccttca
       61 ccgaattggg cattcagcga aataacgctt ttagctcctt ccgcttcttc aaagatatca
      121 ttgaaggggg caaagtaacg gaacttactt gctgtctcat ttattttatc aatctgtttc
      181 tttacaaact tgtagatcca gtcgtaaata aactcaggca actgtctgtt ttttatgtaa
      241 gaatccgtat tgactttcct gttcacaaac ccctgcatga aaaagtcagc cagaatcggc
      301 ggaaccactt ctatcttgcg gcctatcagc caatcaatga tctctttttg tgcgaaagga
      361 ttgaatttca agaagatttc tcctacaatt ccgactttag gagtatctac agccctacac
      421 acctcattaa attcagtgat tgccgattgc aacaaagagt tcaacccctt tatgtttctt
      481 ctcagtatca cttcaggtgc cagttgcagg tatttatcac gcagctttgc cgatgcacct
      541 gcttctttct cacgtaccac agacgcataa taaaacttag caatgcaatc actatacaaa
      601 acggcatgaa aagttatcgg tactactttc atccagttga ccttgaacgc gggctggtca
      661 ttatctatgt cactgcccac agagatagag attaccggaa tatccgtata tccggcatcc
      721 accaacgcct tttttatcaa ggaaatatag ttgctggcac ggcattgtcc tcccgtttgg
      781 gtgatggcta cggctatttt tgaaatatca tatttcccgc ttttaagtgc ttttataata
      841 tcgccgacta tcagagtagc cggataacag acctcattat tcgcatactt cagcccccat
      901 tcacttgaat cattatcact gagaggaagg ttttccgcat cataaccggc tactttcata
      961 atagcaggaa tcaaaggtga aatgaacgga gtaaagtaag gaaccagtat cttacggtca
     1021 cggtaagact tgtcatagac aggaacggtc gtaaagtcct ttacatcgcc ttccgttcca
     1081 tccgcattcg caagtttgag gctttcaatc atggaacgta ctctcaactt cattgaaccg
     1141 atattattga tatcatccag tttcaataaa gtcagcgatt tgttatgacg catcagcaaa
     1201 tcccttactt catccaccag aaaagcatcc ggtccacatc cgaacgaagt catctctaca
     1261 aactgaatat tctttccttg tgtcgcacac catttcgcag ccttcaggat acggttcgta
     1321 tacgcccatt gagcaacaaa atgcgcatca cccgtcggta tatccatctg acgcaccaaa
     1381 tcatccgtta tcacattcac tcccatatcc gaaagcatat ccgagacttt gtgctgtatc
     1441 agagaatcgg tatgataagg acgtccggca agcatgacag tcagagtctc tccctttcca
     1501 gtctgctgca atatgttttt gttataatcg accaatgtat taataaaaga gtgctgttcg
     1561 ctttccgctt tttggaatgc ttgctgaatc gtccgatcgt ccacgctcaa accgctcaga
     1621 tattcacggc attgtttaaa caacagattc cggtctttga aagttattgc aggggaatca
     1681 accgatatac cttcggactg cacacttttg ataacctccg aataacctgt cacaatcgga
     1741 caattataac tgttttgttc catccctttt ctttcgaaaa taacaaaagg cataaaaatc
     1801 cggtcgacct tcttttctat caagtcctga acatgactat gtaccagctt agccggaaag
     1861 cagatattgt ccgacatcac catacgcgca ttgtgctcat actttctgaa attggacgga
     1921 tcagacaaac agacttgtat gccacaggaa gtgaaaagag tgtgccagaa tggatattcc
     1981 tcgtacatat tcagacatcg ggggattccg ataatctgct cgggtgctgc aatctctgcg
     2041 ctgcgatgaa acaaaagctc ttctttttgc cgatagacat tcagaccttt ccggttactg
     2101 ctctctccat tcgtgaaaac tttctcgcac ctgtttcccg aataataact tttgccgctt
     2161 tcgaactcgt aacgaatgac cagacaacga ttatcgcaac tcttgcaata taaagaacgt
     2221 gccgaatatt gagctttatt gataatctca tccaatgata cggactcccc ctgatgtttc
     2281 atcgcatata atgcacatcc gaatgctccc atcaattcgg gtgtatcaca ccttgccact
     2341 tccgctcccg agagaagttc aatggcacgg accaccgcat cattgcgcat ggtgcctccc
     2401 tgcacaacaa tatcttttcc caaaacagat atatctttca gtttcagcac cttatacagg
     2461 caattcttga caacggaata tgccagtccg gcggcaatat cattgatcgt tgccccctcc
     2521 ctgagtacct gtttcacttt tgagttcata aaaacggtgc accttgttcc caaatcacac
     2581 ggtgcttccg aatggcaggc tgccagagaa aactcttgtg ccgaataccc cagagattta
     2641 gcaaacgttt caagaaaaga accacatccg gaagagcatg cttcattaat ctccatccgg
     2701 tcaatcacgc cattattcac aaaaataacc ttcatatcct gtccgccgat atcgaggata
     2761 aaagacacat ccttgttcag ataatgcgct gccatataat gggcgatcgt ttcgataatc
     2821 cccgaatgaa gctgaaaggc agacctgata aggtcttccc catatccggt agaacagctt
     2881 ccttttatat tgagtacggc attctgcttc aaacattcat cgttcaactg attcagcccc
     2941 tcttccacag cttttatcgg attgccgcca ttaatattat aataagaata cagaagcctt
     3001 gaatcttcat ccagtacaac aatctttgtc gtagtagaac ctgaatcgat gccgataaag
     3061 acatcctgtg ttccggcttt caagccggaa gatatcatct tatgacggga tattctttct
     3121 ttccatgctt catattcttc attacttgca aaaacaggtt ccaaccctgt tgaagcaagg
     3181 ttaccgttac cgtttaaagt agtgtcaatc ttatcgatca aatgggacag tttacagtaa
     3241 tcctctttat caagatgaaa tagagcagca cctagtgcag ggagcaaagt gccgttggcc
     3301 ggcagtatga tctctttttc atcgagggac aaataatcaa tgaaggcttt ccgcagtgcc
     3361 ggaatgaagg ttaacggacc accgcaaaac aatacgggag ttgtaatatc gcaaccgtgc
     3421 gccagcgtca ctaccgtttg aactgctacc gcacgaaaga tggaagccgc aatattctca
     3481 cgacttacat ttttagctat cagattctga atatccgttt tacagaaaac gccacaacgg
     3541 gaggcaatag gatatacctg tgtcgcattc atggcaagtt gattcaattc atcaatattc
     3601 actcccagta taatcgccat ctggtcaata aaagcgcccg tccctcctgc gcaattgccg
     3661 ttcatacgca aatcggtcgc ttcggcatcc ttaaagaaga cgactttcgc atcttctcct
     3721 ccgatgtcta tcatagaagt cacatgagaa taatcctttt gtatcgcttt cgctgccgca
     3781 acaacctcct gtacaaacgg caacgaacat ttctctgaaa ttcccattcc gatagagcct
     3841 gttatcctca cggaaatatc tttatctccg atttcagata acagctcttt caagaatgat
     3901 agaattgtct cttttgcttt cgcattgtgt ctctcgtact ttgaaaataa tagattatca
     3961 ttttcatcga cggcaactaa cttcgccgtc gttgaaccta catcaattcc tattttaatc
     4021 atgttctaca ctatgttccc cttagtttga cactattgtc aaacacaaaa gtaagaataa
     4081 gttggacaca tcatttcaat aagctctttt tttcggttct tttaacacaa acaaacgatg
     4141 tctatttctt ccggctatct atttctttaa gcaattcatc tacagccatt ttgagttgcg
     4201 tgtcctctcc tttcactacc gtctccgggc tgttggcaac tttgatatca ggttccagct
     4261 gagtattttc cagataactg ccatccggta gacgataacc gatgatagga atcccaaata
     4321 ccaatgaagg atcctgcaaa gtttcccaag acacacttgt catagttccc ggaacaggca
     4381 tacctaccag ttttccaata ttctgatgct tgtacaccca cggggtacca tgcgcattcg
     4441 aataattggc ttcacactgc aacataatag aaggcttgtt ccagcgacga cttggcatat
     4501 cacaggcttc acgtccgcgt accacctgag tgaaatattt ctgaccactg aaaagaattt
     4561 caatatcttc atgcagacga ccgcctccgt taaaacgggt atcgatcaca attccgtcac
     4621 agttattgta ttttcccaga atatccgagt aaacagtacg gaaactgcca tctcccatag
     4681 attgaatatg aacgtatccc aaacgaccgc cggaccattt ctccacatcc tcagcacgtt
     4741 gtttcaccca acgtttatat aataagccat taagctgtcc gcttgtgaca ggttttacca
     4801 cttcttccca acgttcctta ttctgtgggt tgtacagcga aaccagtgtt tttttccctg
     4861 ccttattatt caaaagatca gtgatgtcct tatccggagt tatttcttcc ccgttgattt
     4921 tttctataat gcaccctgcc tttactttgg tacgggaatg atcgaacggg cctttctcta
     4981 cgatttcagc aatctgcata ccttttccca gataattcca gtcaaacaat aagcccagat
     5041 tagaggttac atccccattg cccctcggag aatagcgccc tccggtatgc gaaacattca
     5101 gttcacctaa ccattcgctc agtaattctg caaaatcata gttattatca atatgcggca
     5161 gaaatttacg ataggcagct gtcatggcat cccagtccac tccgtgcata ttaagattgt
     5221 agaaacgttt ttgatgttgt ttatatacat gatcgaacat tgcctcacgt tcggctgcca
     5281 aatccatttt catttcagcc tgataactga taggtttcag agcatccgac ttcgcgtcca
     5341 ttttctgcat atttctgctt cccagcaaga agatatctcc ttttttatcc agcatcagtg
     5401 atgaccagcc ggaattaagt ttatggagac gcttcgtgcc tttttcacga agattcattt
     5461 tccaaaggtc atacccctct tcgaaagctg aaaagtaata cagattttct ccatctttgg
     5521 aaagaatagc actacctaaa tcagaagagt taggagtcag gcgtacaata cggtcctcaa
     5581 taccgctgag ttccacaaca atatctttct tgtctgcctt gtcnnnnnnn nnnnnnnnnn
     5641 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5701 nnnnnnnnnn nnnnnnnnnn nnnacttccg tcctttttct tatcaccgtc tttctccttt
     5761 gctttcttct gctccttttc aaattctttg agcagttcga aatcctcttt actcaaacga
     5821 taacggtcgt aagcatcctg attcaagaat accagcatca catcctgttg tgatccccag
     5881 gaagcatgcg cacgcatacc ataacgttcg gtctgaaaca gaatggcatt cccatccagc
     5941 acccaacgtg gagagccgct aatataaccg ctgttagtca gattagtgat agtacctccc
     6001 tgtgcactga caataccgat atccgaatag ggatcatgac gattgccgat aaactcaagc
     6061 gtaaaccact tgccatcggg cgaccattcg tagtcgaatc cgcctcctgt attgtaccat
     6121 gtagaaccgt ctgtcacctg acgtactttt ttggttttca gattgagtac catcaaccgg
     6181 ttacggtctt cgataaaagc cagttcctta ccatccggag agtattgcgg gtaagcacgt
     6241 tctacggttt tggaggggag caatacttcc tcttcaataa gagtggcgtt agggaaattc
     6301 gcctcttctt tacgagctat cttagcggta taaagttgcc agttgccggt ccgctcgctg
     6361 gcataaacca gtgtacggtt gtcgggagca aaagatacac cggattcctt tgccggagta
     6421 tttgttattt gcttggttgt agcataatcg gttgaagtta caaaaacatc acctcgcaca
     6481 ataaaagcca cctgcttacc atccggagac acagaagcgg aagtcgcacc ctgagaaaat
     6541 ctgagagtgg caatctcttt ttcatcatca cgcacaagat caacatttac tttctttggg
     6601 cgggcattgg gctcttgtgt ataaagttct ccgtcatacg tatagcacaa agttccttta
     6661 tcgctgattg acaagaaacg caccggatgc gtgcggaaag tggtgatggc tttcacttcc
     6721 tgcggagtgt tcagggcaaa gttatataca ttaaatgaac cgccattgcg ctcacttaga
     6781 aaataaaccg aattaccatc cggtgcatat accggattac ggtcttctcc ttcccgattg
     6841 gtcagattgg tatgttttcc ggtcgaagca tcgtatagcc aaacgtctct tgttatagat
     6901 gaggtatggt gttttctcca ttcatcttca aaacctttac ggtcctgata aaggaagttt
     6961 tttcccgatt tatcaaagca tacccattcg gcaggagtag ccaacacttg ttcggtacgt
     7021 cctccggtaa ccggaacttt atataattcc gtcatggctc cggtaggaaa aagggcactt
     7081 tccgcagggt cctgaatgga ggcggagaaa agtacaaatt taccatccgg agtgaaagcc
     7141 gaaggaatct ccgaggcaga atgataagtc aaccgacgtg cagttcctcc atcggcagac
     7201 atgataaaga gatcgaagtt cccattccgg tcgctggcaa acgcgatttg tttaccatct
     7261 ggcgaccaaa caggattagc ctcataagaa gcttgtgttg ttaattgggt agcggttccc
     7321 ccttgaacgg ggactttgta aatgtcgcct ttataacaaa agacgatttc ctttccgtcc
     7381 ggtgagatac gtgcatcacg catccacaaa ggagtaatag catagctgga taatgcagtc
     7441 agtaccagcg ctaaagagat gattattttc ttcatattat tgtatgttta tatatttatt
     7501 ctatattcct tgtttcatga gaagaccgta tttctagtta gtttaagtca cttccgatat
     7561 tttagcgatt ttttccatgt gactgctgtc tgttccacaa cacccaccaa atattttaag
     7621 atgacaatca gatttcaact ttaaaatagc ttcactcaga tcggttgccg aagaagtatg
     7681 taaatgattt gctccatcca attctttata tgacaattgg gaagtatttg cttgtatacc
     7741 ccaaaagcga gattttaccg tttgtgtttg attgaactta tgagaaagtg cttcgtaaac
     7801 aatatcagga tgaacacaat ttgtcatata gcacacaggt ttgttagaca catgattatc
     7861 aatgcaatgt atggcatcat caatggtatg cccatctatc agttttccgt ctctttgaat
     7921 cgtaaagctg ataatataag gaatatccgt atcagacata gcgactgcca tcccgatagc
     7981 ttccgtcaat acaggcataa tacctgcata taaaaaatca actttggcag atttaaacaa
     8041 accggcctgc caactatgga agtctattgc ctcttccaga tttagagcct cttcgccagt
     8101 gtatgcatct cccttacatc ccatcaaacc accgatatac atatctacat ttgctgcttc
     8161 ttttatggaa cgaagaaaat ccacattatc tgcaataatg gattcattgt atccagccat
     8221 ataaatccgt tctttattgg cccttcttgt tggagttgtt gcaagaaatg gtagttgata
     8281 cctatatgca atatcaatat attcattcca tagcgtttct aatgccagtc tacctttctg
     8341 ctgatagact aagtcagcca ttgcaacagt accactgata tccaaatcaa actccctttt
     8401 tagtcgctcg cctaaagcac cttccattaa tataaaggga taagaatcta tgcagtcttt
     8461 aaaattcatc cagtttgttt ttatatattc ttgtttagtc gtctcagata attataacag
     8521 agaatccgtc tgaatcaatt tccctgtatg gttataaaat attctgtctc caaaatcctt
     8581 atagaagaaa gcatatttat ctactcccgt acaatggcag acacctatct tttgaggtaa
     8641 atattcgtgc aaataatcag caataacctg atatttggat tcttctgcat tatgaatatg
     8701 aaatccacct aaaagcaaat tacaggggag ttccggaaat gccgttctta cagtccgcaa
     8761 tatatttgta ataccccggt gggaacaggc acttaaaatg gaaagtcctt caggctcaac
     8821 cagtaccata gctaactcgt ccggaaaggt atcggggact ctagaaccat cttccttttg
     8881 aatccaaaat cgttcaaaat gtgtatcctt ccggtctata atatccacag agggaaaaag
     8941 aaatactccg ggaaccagtt cagtcaactc atcaataaaa cgaaaacgag aaagatcaag
     9001 cgagcgtgta tatttcattc cattctcacg ttcatccttg aatttaggaa aaaacacttc
     9061 gcgtttgcaa acaaccgttg cttcggcatt tagttcaaga aaatggcgta gtccacccgt
     9121 atggtcactg tgaccatgag ataatactaa ataatctact ttttgcaagt caatattcaa
     9181 taaccgggcg ttacggataa ataaatcaga agctcccgta tcaaaaagta atctgttttc
     9241 cggtgtctca atatagaggg aaagaccatg ttctgcctgc aatttacgtc catagacaca
     9301 attttcgaca agagtcgtta ttttatagtt catgtggttt ggttcttaat caaatactac
     9361 gaaataaaaa gttctgctac aaaattataa taattctacg gcagaacaag taatcaatca
     9421 atttaaatcg actgtaaggg taaaagattt tgtttcaggc ttctattgcc gaattattca
     9481 ttttgtagtt tgaatacaaa taattacttt tacatccata tcaaaccctt taaataaaga
     9541 atcaaaatgg agaaagaagc aaaaggtaaa gtaaatacag ttcagataca gtactatcaa
     9601 tctccatgcg ggaaattgat actcggttct ttcgagaaca agctctgtat gtgtgactgg
     9661 gtggtgagtg aagaacgcag agcaacaatc gataaacgaa tacaaaaagc gctaaatgct
     9721 cagtacgcaa tagaaaactc tgaagtgata acgcaaacga tcagtcagct agatgagtat
     9781 ttttcccgtc aaaggactac gtttgatatt cctctgcttc ttgtcgggac agagtttcaa
     9841 aagagtgtat ggaatgaatt attaaacatt ccctacggaa caacgatatc ttatgctcaa
     9901 ttatcacaga gactggataa tcctaaagct atccgcgcgg tagcctcttc gaatggagca
     9961 aattctattt caatacttat tccttgtcac agggtgatcg gcagtgatca taaactgacc
    10021 ggatatgccg gtggtcttgt agctaaaaag actttattgg aactggaatc gaacgaaaga
    10081 agattattgt aacagaatca ttaaactaaa cttctctcat taaatccaga caaaaatatg
    10141 gtgtcactat cccattacta tagtgtcact atcatactgc tttagtgtca ctatcctaca
    10201 ggtatagcgt cactatatac tcagcatagt gacaccatcc tgaaaggttg ttatataaga
    10261 cgggaaatgt ttacctaaag cgaacgttta caccattttt cccatctcat aggcttcctg
    10321 catgtaggga gtatctttta tttctcctac cttccaggca cctattccat aaatcactcc
    10381 tttttcctgc ggattttcca gacaatcaag gaagccacgg aaaccatcaa tcgtacgttc
    10441 catcatcccc ttatcattct ccgccgctgc aataatgaaa taaaattcct tattcgttat
    10501 ttccgtataa cgtgcacaac aacggtcaat cataatcttc atctgtccgc acatcgtata
    10561 gaaataaaca ggtgttgcca ttacgatgac atcagccgca atcattttct ctacaatttc
    10621 tgctgcatca tctttctgcg ggcag
//
