LOCUS       gnlProkkaLDLOKCNF_22   12350 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LDLOKCNF_22.
ACCESSION   gnlProkkaLDLOKCNF_22
VERSION     gnlProkkaLDLOKCNF_22
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 17:01:05
            Original ID  :: gnl|Prokka|LDLOKCNF_22
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12350
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12350
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[3036:7350]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3037..7350
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..12350
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12350
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             3..1814
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 72;
                     E-value: 6.1e-22)"
                     /gene_kind="transport"
                     /locus_tag="ctg22_1"
                     /transl_table=11
                     /translation="MYNGLNNTTDPTSDIRLTLGNIRTIQINVMGEVVQPGTYALSSFS
                     TVFHALYRAGGVSDIGSLRNVQLVRNGKNIATIDVYEFIMKGNTQDDIRLQEGDVVIVP
                     AYDVLVKISGKVKRPMRFEMKKEENLATLIKYAGGFEADAYTRSLRVVRQNGEEYEVNT
                     VKDIDYSIYKMRNGDVVTAEAILNRFTNKLEIRGAVYRPGIYQLSGKLNTIRELVHEAQ
                     GLTGDAFLNRAVLYRQREDLTSEVVQIDIKSIMDGTSPNLALMKNDILYIPSIHDLEDR
                     GNVTVHGEVAHPDSYPYADNMTLEDLIIQAGGLKEAASTVRIDISRRIKNPRSTADNDT
                     IGQMYTFSLKDGFVIDGQPGFILEPYDQVYVRRSPGYQAQQNVAIEGEILFGGNYAMTS
                     REERLSDLVNKAGGPTNYAYLRGAKLTRVANASEKKRMGDVIRLMSRQLGEAMIDSLGI
                     RVEDTFTVGIDLEKALSNPKSNADLVLREGDVISIPKNTNTVTINGAVMVPNTVSYMKG
                     KNVDYYLNQAGGYSDNARKSKKFIVYMNGQVTKVKGSGKKQIEPGCEIIVPGKAKKKGN
                     IANILGYATSFSSLGMMIASIANLIKK"
     CDS             1825..2973
                     /locus_tag="ctg22_2"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             3037..3756
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 54.5; E-value:
                     1.6e-16)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 9.2e-16, bitscore:
                     50.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             3777..5078
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_4"
                     /sec_met_domain="CTP_transf_like (E-value: 1.1e-12,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 1.2e-120, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.3e-62, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             5095..6219
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 6.1e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.3e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             6229..7350
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg22_6_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_6"
                     /sec_met_domain="Aminotran_5 (E-value: 8.7e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        6319..7326
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg22_6_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg22_6_Aminotran_5.1"
                     /locus_tag="ctg22_6"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             7347..7490
                     /locus_tag="ctg22_7"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             7693..9177
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_8"
                     /sec_met_domain="Polysacc_synt (E-value: 7.7e-31, bitscore:
                     99.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLS
                     FLFKLDSFFCILTLIIKTKNIDENIKKDFSSNSKDN"
     CDS             9131..10390
                     /locus_tag="ctg22_9"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             10399..11148
                     /locus_tag="ctg22_10"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKNSK"
     CDS             11148..12188
                     /locus_tag="ctg22_11"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 aaatatataa cggtctgaac aacacgaccg atccaacttc cgacatccgt ctgacgttag
       61 gtaatatccg tactattcag attaatgtga tgggagaagt cgtacagccc ggtacctacg
      121 ccctttcttc cttctctacc gtcttccatg cgctttatcg tgcaggcggt gtgagtgata
      181 tcggtagcct ccgaaacgtt cagttggtac gcaacggaaa gaatattgcc accatcgacg
      241 tctacgaatt tatcatgaaa ggcaacacac aggatgacat ccgccttcag gaaggtgacg
      301 tcgtgattgt tcccgcttat gatgtattgg taaagatcag cggcaaggta aaacgtccta
      361 tgcgttttga aatgaagaaa gaagagaacc ttgccacttt aatcaaatat gccggcggct
      421 ttgaagccga tgcctacacc cgttcattac gtgttgtccg tcagaatggt gaggaatacg
      481 aagtcaacac agtcaaagat atagattaca gcatttataa aatgcgtaac ggcgatgttg
      541 taacagccga agccatcctt aaccgcttca caaacaaact ggaaatccgt ggcgctgtct
      601 atcgtcccgg tatctaccag ctcagcggta aactgaacac gatccgcgaa cttgtccatg
      661 aagctcaggg tctgaccggt gacgctttcc tgaatcgtgc cgtcctctat cgccagcgtg
      721 aagacctgac cagtgaagtt gttcagatag acattaagtc tatcatggac ggcacttccc
      781 caaaccttgc cctaatgaag aatgacatcc tctacattcc aagtatccat gacctggaag
      841 accggggtaa tgtcacagtt cacggtgagg ttgcccaccc tgattcctat ccttatgcgg
      901 ataacatgac acttgaggat ctgatcattc aggccggtgg cttgaaagaa gccgcctcta
      961 ctgtccgtat tgatatatcg agacgaatca agaatcctcg tagtactgcg gataatgata
     1021 cgattggtca gatgtatacc ttctctttaa aggatggttt tgtaatagat ggtcagcccg
     1081 gttttatcct tgagccttat gatcaggttt atgtccgtcg cagtccgggc tatcaggcac
     1141 aacagaatgt agccattgaa ggtgaaatcc ttttcggagg aaattacgcc atgaccagcc
     1201 gtgaggaacg tctttccgat ttggtgaata aagccggtgg tccgaccaat tatgcctatc
     1261 tgcgtggtgc aaaactgacc cgtgtggcta acgctagtga gaagaaacgt atgggtgatg
     1321 taattcgcct tatgagcagg caattgggcg aggccatgat tgactctttg ggtattcgtg
     1381 tcgaagatac ctttacggtt ggaattgatt tggaaaaagc cttgagcaat cctaaaagta
     1441 atgccgatct tgtcttacgt gaaggtgatg tgatctccat acctaagaat actaatactg
     1501 taactatcaa tggtgctgtc atggttccga atacggtttc ttatatgaag ggaaagaatg
     1561 tggattatta cctgaatcag gccggtggtt attctgataa tgcaaggaag agtaagaagt
     1621 tcattgttta catgaatggt caggtgacga aggttaaggg tagtggtaag aaacagattg
     1681 agccggggtg tgagattatt gtgcctggta aggctaagaa gaaagggaac atagctaata
     1741 ttttaggtta tgctacttcc ttcagttctt tgggaatgat gattgcttct attgctaatt
     1801 tgataaagaa ataaatgacc tattatgatt gaaaagcaat cttatcaaga accgttttct
     1861 gaagtggata aaaggaaaga tgatgaaatg gaaatagact tgatggctat tttttataag
     1921 attattactg ttcgtggagt actatgcaaa gctgctggag tgggagtaat aattgctata
     1981 gtggtggcat tgagcattcc caagcaatat acagtaaagg ttaccctttc tcctgaaatg
     2041 ggtaatgcga agggaagtaa tggtttagcc ggacttgctg cctcgttttt gggagatggg
     2101 gctctaatag gggaaagcac agatgccttg aacgcttctc tttcagcaga tattgtttct
     2161 tcaactcctt ttttattgga acttttagaa atggaagtct ccgtttctaa aaaggatgat
     2221 aaaatgactt tggggtctta tctcgatgaa gagtcatctc cttggtggga ttatcttata
     2281 ggttttccgg gcatagtaat aggaggagtt aaatcattat tcggagaaga tacggttcct
     2341 gccagtggag ggcggcaagg aactatcgaa ttgacgaaag aagtaaatga gaagattaat
     2401 tttcttaaaa agaagattag tgcatccatt gataagaaaa ccgccataac gagcattacg
     2461 gtcaccttac aaaatccgca gatcactgcg gttatagcag attctgtcgt tcataaatta
     2521 caggaatata ttattgggta tcgaacttca aaagtaaaag aagactgtgc gtatttggaa
     2581 cggttgttta aagaacgtca gcaggaatat tatgctgctc aaagaaaata tgcggattat
     2641 gtagacgccc atgataatgt ggttcttcaa agtgtacgtg ctgagcagga gcgtttacag
     2701 aacgacatga gtttggctta tcagatatat agtcaggttg ctaatcagtt gcaggtatcc
     2761 agagccaaag tacaggagga aaagccagtc tttgcagtag ttgagcctgc cgttgtacct
     2821 ttgaaacctt caggtatggg actcaaaatt tatattttat tatttgtgtt cctgtccgta
     2881 tctggtactc tcgtgtgggt gttttttggc aaaagtctgc tggctagctt gagaaaagaa
     2941 ctgaaaaata aggagataga acaggataaa tgatgctaaa acgtcgttta caacattctt
     3001 acatcaatta aattcactta ctatattatt aaacgaatga tacgtacagc tatgataatg
     3061 gctgcgggca tgggaacccg ttttggccaa tatacagaat tgatacctaa agggttcgtc
     3121 aaagtgggag gtattccaat gatagttcgt tctattgata ctttgttatc atgtgacatt
     3181 gagcgaattg taatcggtac aggatataaa caagaagttt atgaagaatt gaagacagac
     3241 tatcctatgc ttgaaacctg ttttagtcct cgttatgctg aaacaaatag tatgtatact
     3301 ttatataata cgcgggagat tctgggcaat gatgattttt tattgttaga gtcagatttg
     3361 atttttgaga aacaagcaat aatgagctta ttggagtgtc ctgcggcaga tgcaatgcta
     3421 ataactccag tgacaaagtt tcaagatcag tattatgtgg aacatgatga taattttcgc
     3481 ctttcttcat gttctgtcaa taagaataaa ctaaacgcta aaggcgaatt ggtcggcatc
     3541 cataaactat ccggttcctt ttacaaaata atgtgtgctg attatgcgag tattgttgat
     3601 gaacaaccca atttgggata tgagtatgaa ttactacgaa tatcttgttc tcaatctcct
     3661 gtttatgtgc ataaagtaga agggctgaaa tggtatgaaa tcgatgacat atcagatttg
     3721 gaatatgcag agaaatatat tgttccgtat tgttaattaa aataatatat caaattatga
     3781 gtaagacagt ttatattggg atgactgcgg atattatgca tccaggactt atccgcatta
     3841 ttaatgaggc tactaaatac ggtgatgtta taattggtct tcttacagat aaagctattg
     3901 cggagcataa acgccttcct tatctgacct atgaacaacg aaaagaggta gttcagaata
     3961 ttaaaggcgt atgtaaagtt gttcctcaag aagaatggag ctatgttgag aatctcaaac
     4021 gcattaaacc tgactatata attcatggtg acgactggaa aaccgggcct ttacgtgaag
     4081 aacgtgtgcg cgtatttgaa gtgatgaatg aacagggagg aaaggttatc gaaattccat
     4141 atactttggg aattaattca tcttctttgg ataaagatat taaggctata ggtacaaccc
     4201 ctgatgtacg tttaaaatca cttcgtcgtt tgataaatgc caaacccgta gttcgtattt
     4261 tggaagctca tgatggacta tgtggcttga taattgaaaa tcaggaaata ttaaaagggg
     4321 ataagaggga agtatttgac ggaatgtggt ctagtagcct tacggattca accagtaaag
     4381 gtaaacctga tattgaggcg gttgatttaa ctacccgatt gcaagatttg aataatattc
     4441 tggagtgtac tactaaacct attatttttg atggagatac aggtggtaaa attgaacatt
     4501 tcgtatttac agtacgcact ttagaacgtc atggaatttc agctataata attgaagata
     4561 aagttggatt aaaaaagaat tcattgtttg gtacagatgt tattcaaact caagatacaa
     4621 tcgaaggttt ctgtaataag atcaaagcag gaaaggcatc tcagattact gatgatttta
     4681 tgattatcgc tcgtattgag agccttatag cgggaaagcc ggtaagtgat gctttagaga
     4741 gagcttttgc atatgtccaa gcgggagcgg acggtattat gatacatagc aaaaataagt
     4801 cgggtgaaga tataaaagaa ttttgtttgg cgtttcgaaa acagtatgct catgtaccta
     4861 tcgtggttgt gcctactaca tatgatcata tttatgagtc tgaattgtgt gattggggtg
     4921 tgaatataat tatttatgct aatcatatgc ttcgtgccgc ttatcctgct atgatgaatg
     4981 tcgcaaagat aatattagag aatgaacgtg ctttagaggt gcgcgaactg tgtatgccca
     5041 taaaagaaat attggaactg attccaggta ctaaataaaa agaggaatat cattatgtta
     5101 agcgtagaaa aagtttatga aacgtttctg agtcatgacg ttgatttttt tacaggagtt
     5161 ccagactcat tactaaaaaa tatttgtgcc tatatcacag accatacttc acgtgagaaa
     5221 catatcatag ctgctaatga aggtgcggct gtaggaattg cttcaggtta ttatatggca
     5281 tcaggtaagg ttcctgtggt ttatatgcaa aattccggct tgggtaatac tgttaatcct
     5341 ctgctgtctc ttgcagatga acaagtatac agttttccaa tgcttttgat gattggctgg
     5401 cgtggtgaac cgggaacaaa agatgaacct cagcataaaa aacagggtga ggtaacttta
     5461 gatttgttga aagcaatgcg gattccttat ataattcttg attcaaatga gaatgatgca
     5521 tttattcagc tccatgatat catacaatca gcaaaaacta agaatattcc tcatgcaata
     5581 attattcgga aagatgtttt tggcaaatat aaacttcaaa aagagttcgg atgtaattat
     5641 cctttatctc gtgaggatgc tttgcaaata gttgtggatt atctgcctga aaattcagtg
     5701 gtcgtttcta ctactggcaa gctttctcgt gagttatttg aatatcgaga aatgaaagag
     5761 caaggtcatg aacatgattt tctcacggta ggctctatgg gacatagttc atcaatctct
     5821 ttgggtattg ctatagcaaa gcaagataga cctgtttatt gcttggatgg tgatggagca
     5881 tttattatgc atttaggggc aattagtaac attggcgatt tatctcctaa aaactattat
     5941 catattttgt ttaacaatgg tgctcacgag tctgtaggag gacagcctac tttaggattt
     6001 agtttagata ttccggctat tgtccggggg agcggatata agcatactta tactgtttgt
     6061 acaaaagttg aaattgaaga agcaatgaag cagcttccaa agttatgtgg tcctgttttg
     6121 ttggaaataa aggttaaaat agattctcgg gagaatttgg gacgtcccac gactactcct
     6181 atagagaata aggagcattt tatggatttt ttaaaataaa tatattcgat gaaaatagaa
     6241 agaaaaatat tattaaatcc tgggcctgcc actactactg acagtgtaaa aatggcacaa
     6301 gttgttccgg atatttgtcc tcgcgagaaa gaattcgcag gtatgatgaa acaacttcgg
     6361 gacgatttgg tcagagttgc tcatgggaat ttggaaaaac ataccgctgt attattttgt
     6421 ggctcaggaa ccatcaatat tgatatatgt ctaaattctc ttcttcctga agacaaaagg
     6481 gtgcttatag tgaataatgg ggcatatagt acccgtgctg tagaagtgtg tcaatattat
     6541 ggtttgcctc atattaattt ggaattttcc gtttacgaac gtcctgattt atcggtggtg
     6601 gaaaatgtgt tgcaagaaaa tcctgatata gctatggttt atactactca tcacgagacg
     6661 ggtacaggaa ttctgaaccc tattcgcgag atgggcgcta tagctcataa atatcaggct
     6721 aaatttgtcg tcgatactac ttcttctttg ggcatgattc cttttgatat agagaaagat
     6781 aatgtggatt tttgtatggc atctgctcaa aaaggacttc aagcgatgac aggtctttct
     6841 tttattatag gcaatgagga acagattaag ttttcaaaaa aatatcccaa gcgttcttac
     6901 tattgtaatc tttatttgca gtatgagaat tttgagagaa caggtgaaat gcattttact
     6961 ccaccggtac aaactattta cgccactcgt caggcattaa atgaatattt tgaagtgggt
     7021 gaagaagcta agtttgcccg tcacaaaaga gtttttgagg ctattcattc aggtataaat
     7081 gaaattggtc ttaaaagtgt aataaagcgt gaatggcagt caggactggt tgtctcagtt
     7141 caatacccag aagatcccaa ctgggatttt gagaaaatac atgattattg ttatgagcgt
     7201 ggatttacga tttatccagg taagatatca actgaggata cttttagaat ctgtgcttta
     7261 ggagagatag aagtagatga tattgagaac ttctttaaag tactaaaagc tgcattaaat
     7321 cattataacg tcacattacc gatgtcatga ttgcagaaat attattgaag attcgtcatt
     7381 tttatttttc ccttcgtggt atacacttcc atccggaaag tgttatttct ggagtgccta
     7441 ttcgtagctt tcgcttagta ggcaaatatg gcaatattaa tttgaggtga tgcattagga
     7501 gttctttatt cttataaaaa ggcatcggta gttataggag ataatgtttg tgtagggtaa
     7561 tttgctttta gtgggagaga ccatattaga attgcggtaa ggggcgaaga agataataac
     7621 caattagtga gaatattgga aaaatataat tgatatcggt aaatgtagtt gtttttatac
     7681 tgtatttaag taatggaaaa tctaaagcag aaaactgtat caggaataat gtggagcgct
     7741 atagaacgtt tctctttaca aggagtacag tttataattc aaataatatt agctcgtttg
     7801 ttactaccat cggattatgg tatgatcggg atgttagcta tttttcttca agtcgctcaa
     7861 gtatttatag atagcggttt tacaaatgct ttaatccaga aaaaagatag aactgaagag
     7921 gattttgcca ctgtctttta ttttaatatt cttgtcgcag tattattcta tggtatattg
     7981 tttttttcgg cttctttgat tgcagacttt tataatatgc cgactttagt tcttgtaatt
     8041 cgttttatag cattgtcgtt gataataaat gctttatcgg ctattcacag aacgaaatta
     8101 attatttctg taaactttaa aactcaatct aaaatttcat taggtgcagc ttttatatca
     8161 ggcgtgattg gaatatggat ggcttatgtc ggttgcgggg tttgggcttt agtttggcaa
     8221 actctcttaa atagtataat tttgacaatt ttgttttact gtttagttca ttggaaacct
     8281 ttacatactt tctccaaaag ttcttttgaa agattattca atttcggatc taaattattg
     8341 atctcaagtc ttatcaatac agtatatcgt aatctgtata ccattgtaat aggaaaaaag
     8401 ttttctgttg tagagcttgg ttactataca agagcagaac aatttgctat ttttccttcc
     8461 aataatttaa atgctttagt ttctagagta gcgtatccta ttttaagttc cattcaagat
     8521 gatgataaat gtttaacaaa cgcatatcga aattatatca gattatcctc atatataatt
     8581 tttcctttaa tggtaggttt acttgttttg gctaatccta ttattagtct attgttaaca
     8641 gataaatggt ctggggttgt tattctttta cagatattat gtttggattg gatgtttgat
     8701 catttgagcc aaattaattt gaatttatta tgggttaaag gaagatctga tctgtcgtta
     8761 cgtcttgaaa taataaaaaa gacgattgct atattcattc tttttgtgtc aattccattt
     8821 gggcttgagg tgatgtgttg gggtagagtt atttactctc tgatagcgac atatttgaat
     8881 acatattata ctaattctct tattgatttg accttaaagt tgcaagttaa agatgtattt
     8941 ccaagtttaa tactctcttt cataatgggg gggatcgttt ttatatgtat ttctttcttt
     9001 gaaactgata tagtaaaaat tgtgattgga tgtattactg ggatgtcctt ctatatttta
     9061 ctttcttttc tttttaagct agattctttt ttttgtattt taacattgat cattaaaact
     9121 aaaaacatag atgaaaatat taaaaaagat ttttcaagta atagtaaaga taattaacca
     9181 ttgtgtgcca gttgatagta gatcattgta ttttattcct catcctaatt gtagaacaga
     9241 taaatatgat attataaatt attcgtcaga taatgttctc gttctgttaa attatttgct
     9301 aaaaaaagat agtgctgaat attataaaat atatgttgaa atttatgatt cttctcgtat
     9361 ttcagaatat caagaatata tttatggcat aaatcctaat attaggtgta cttttttatg
     9421 tgcatgtgtt ggacgttttt tctttaataa agtatctttt aaggatatgt tgtatgcctt
     9481 tttttgtttt tgtagagcaa gtaaatgttt tacagctact ttttattatg atttttcatt
     9541 taaaaaacgc tctcaacaga ttatttgttt ggggtattat actccattca aagatgatta
     9601 tcatatggga gatcattctt atgataaatt tcgtaataca acatgtaact catttgatta
     9661 ctctattgct acttcttgtt taagtgctag aataatttca atagattgtg gaatctcata
     9721 tgataaattc aaagtcttag gatttcccag aaatgatttg ttgatatcga aaaataattg
     9781 caatgttatt aaaagagaaa tttcgaaatt tgcgggatat gatgtaacta aatatatagt
     9841 ttatactcca acttttcgtg attatgagac tgttactgaa ggtaatttgc gttcaatact
     9901 cggatatgtt gattgtgatt tgttgaagtt atcgaaaata ctattgaagt ttaatgcggc
     9961 tttaattctt aaattacatc ctttgcagaa taaaacagtc ttaaaaaaag atttacccaa
    10021 aggtatactt gtttttgaac aaacatataa atatggattg tatgatcttt tgtcattttc
    10081 agatggaatg attactgatt atacttctac ctattttgat tttttattgg taaataagcc
    10141 agtcatattt aatttctacg atattgaaga atatcgtaga gtaagaggtt tctcatttga
    10201 gccaatagaa tttttttgtg caggtgatat tgtttacaat tataatgaat tgatagatgc
    10261 tgtgatggga cttctggctg ggaaagatat tcatgctgaa catcgacgtc atatttcttt
    10321 attgatgaat caatttcaag atgataattc aacaaagaga atatgtgaca tatttttaaa
    10381 tgaaatataa taaataaaat gaattatgca tttgtggtgc aggcacgttt aggttctaca
    10441 cgtttgcctg gaaaaatatt gaaacctttc tatggtaatc aatcgattct tgacttaatg
    10501 gttcataagc tttctgctat atcgaatatt ccagtaatta ttgctacaac aaattctgtt
    10561 atcaatgaac ctattgaaaa gaaggcactt gcattagggg taaagtgctt cagaggtgag
    10621 gagaatgatg ttttaaaacg attcattgat gttgctgaat attttgatat acagggtata
    10681 ttccgaatat gttctgataa tccattttta gatgtacatg cggcaaggca attggtcgaa
    10741 atagcaatga aatcttgtaa cgattatata agttttgata ttgatggtac tccatcaatt
    10801 aaaactcatt tcggtttttg gggagaattt gtaacgcttg atgcgctgaa gcgagttata
    10861 ggatttactg atgatttatt gtatcgtgaa catgttacta attatatata tagtcatcct
    10921 gaacttttta atattcaatg gatttcagga tctccagtcg tgtcaaaaca tcataatatt
    10981 cgactcacga ttgatacgtt agaagatttt tctgtagcac agagaatata tagggattta
    11041 caagaaaaaa gagtggaaat atcgatagaa gtgattgtag actatgttcg aagacatgca
    11101 gaatacattc aactgatgaa acaacaaata aaaaaaaatt ctaaataatg aagaatactt
    11161 atattattgg tgaaataggg cagaatcata atggttctgt tgacttggct aagttgatta
    11221 ttgaattaat ctcacgacct gtacatgagg atgtttttgg tatggatttc atgccaatga
    11281 atgctgttaa aatgactaaa agagatttat cagaagaatt ggctgtttct caaatgaatc
    11341 aaatatatga caatcctaat tcttttgggc gtacttatgg tgaacatcgt gcttttcttg
    11401 agcttgatga tcaagcgcat tttgagattt ataaatatgc taagtcatta ggattagatt
    11461 ttatcgagac gttatgtgcc aaaggatgtc tgtctttgct taaactgttc acaccggata
    11521 ggctaaaagt tgctagtcgt gatttgacta acttaccatt gcttgaagca ttagcagaaa
    11581 ctcatattcc tattatatta tcgacaggaa tggctggtca aagagaactt gacaatgcat
    11641 tagatgtgat aacgagatat catagtaata tagctattct acattgtgta tctcagtatc
    11701 caactcatcc aaataatttg aatctacgta caataacata tttgaagaag cattacaata
    11761 agtttgagat aggtttttct gatcatacaa taggtatttc tgctgctaca gctgctgtag
    11821 cgatgggagc ggaaattata gaaaagcatg taacaattga tcggcatatg aaaggaacag
    11881 accagcttgg ctctttaggt ccagatgggg ttaatcgtat gattcgagat attcgcatag
    11941 cagagtgttg gcttggtact gaagatcttt atatagaaaa aggggtggag aagtctaaga
    12001 taaaacttga acgttctatt gccactcgaa aatatattcc agcaggtagt attattcaag
    12061 agtcggacat tcatttactg agtcctggtg atggttataa atggatagat aaaaaaaatg
    12121 taattggtca ttttgctaaa caagatatat cagcgaatga aataatatat cctgatttta
    12181 ttgaatagat atattcctac tgcaacttgt attacggtat agagtactgc ctgctataag
    12241 ctaagtagtg attaataaat aagggtaaaa tactaaaaaa atgaaagaga taaagcttat
    12301 acttacagat attgatggcg tttggactga tggcggaatg ttttatgatc
//
