LOCUS       c00015_gnlPro..        13262 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JPMIPHLK_15.
ACCESSION   c00015_gnlPro..
VERSION     c00015_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 21:31:47
            Original ID  :: gnl|Prokka|JPMIPHLK_15
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13262
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13262
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[303:3262]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      304..3262
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..13262
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13262
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             complement(2..214)
                     /locus_tag="ctg15_1"
                     /transl_table=11
                     /translation="MLNSIKIPIYGERPEGGYYFQIYFSNIFLRNNLQVKKLFVPLQRF
                     KRKALLHRSSGEVAEWSIAAVLKTVV"
     CDS             304..2532
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_2"
                     /sec_met_domain="Gly_radical (E-value: 1.9e-46, bitscore:
                     148.8, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate1 (E-value: 0.0, bitscore:
                     1165.8, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELNKTFKDGLWSKEINVRDFVSNNITPYEGDASFLQGPTERTKA
                     VWNHCLKALEEERNNNGIRALDYTTVSTITSHPAGYIDKENELIVGLQTDQVLKRAIKP
                     FGGINVVMKACRENGVEVDDRVKDIFTHYRKTHNDGVFDVYTEEIRSFRSLGFLTGLPD
                     NYARGRIIGDYRRLALYGLDRLIEAKKEDLHNLTGPMTEARIRLREEIAEQIKALKEIK
                     VLGEYYGLDLSRPAYTAQEAVQWVYMAYLAAVKEQDGAAMSLGNVSSFLDIYLEYELSQ
                     GTITETFAQELIDQFVIKLRMVRHLRMQSYNDIFAGDPTWVTESIGGRFNDGRTKVTKT
                     SFRFLQTLYNLGPSPEPNMTVLWSPELPEGFKAFCAQVSIDTSSVQYENDDLMREVRQS
                     DDYGIACCVSYQEIGKQIQFFGARANLAKALLLAINGGRCENTGTVMVKDIPVLTGETL
                     KFEEVMANYKKVLIQIARVYNEAMNIIHYMHDKYYYEKAQMAFVDTDPRINLAYGVAGL
                     SIAIDSLSAIKYAHVKARRNDIGLTEGFDIEGAFPCFGNDDDRVDHLGVDLVYFFSEEL
                     KKLPVYKNARPTLSLLTITSNVMYGKKTGATPDGRAKGIAFAPGANPMHGRDKNGAIAS
                     LSSVAKLRYRDSQDGISNTFSIVPKSLGATQEDRIDNLVTMMDGYFTKGAHHLNVNVLN
                     REMLQDAMEHPEKYPQLTIRVSGYAVNFVKLSREHQLEVISRSFHERM"
     CDS             2537..3262
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 72.9;
                     E-value: 1e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_3"
                     /sec_met_domain="Radical_SAM (E-value: 2.7e-30, bitscore:
                     97.7, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINVHSYESMGTFDGPGLRLVVFLQGCNFRCLYCANPDTIEAKGG
                     TATDPEEIVRMAVSQKAFFGKKGGITFSGGEPTFQAKSLIPLFKRLKEKGIHICLDTNG
                     GLWNNDVEELLELTDLVLLDIKEFNPEHHQSLTGRSNEQTLKTAAWLETNHKPFWLRYV
                     LVPGYSDFEDDIRQLGEHLGTYQMIQRVEILPYHTLGVHKYEAMNKEYMLKGVKENTPE
                     QIEKAEKLFRQYFRTVQVN"
     CDS             complement(3495..4757)
                     /locus_tag="ctg15_4"
                     /transl_table=11
                     /translation="MMKEDEKWIKAFKDKLEDYSEPMPASGWERLERELMPVTEKRIYP
                     YRRWAVAAAAVVLVVTTAVSLYFLNSPVADEIRYATAPSLAVNPDVLPEPALPDVQVAV
                     SEPVKPVGTTSINPVSGYLAKNIDPVIVPEVSSLAEKRPEAVTEEKRAEPQQEATAAIE
                     KKESATAQPPKRKEARRPSGKDKYQLPIGDSSAKRGGKWSMGVGIGNGGGLPTNGSEIF
                     APRPMTNRVDLMTIMNGAVSIPADQEVIFEEGVPYLKSNTTAVVDYEHHQPVSFGLSVR
                     KSLPKGFSVETGLTYTLLSSDIKRQGDTKMQSQKLHYIGIPVRGNWNFLEKKYFTLYVS
                     AGGMVEKCVYGKLADDKVNVKPLQFSVAGAVGAQFNATDHVGLYVEPGVSYFFDDGSKV
                     QTIRKERPCNFNLQAGLRFTY"
     CDS             complement(4809..5357)
                     /locus_tag="ctg15_5"
                     /transl_table=11
                     /translation="MNELELSERCRQGDNRARKELYEQYAGRMLGVCLRYAGDRDMAQD
                     LVHDGFLKIFDSFDKFTWRGEGSLRAWMERVMVNTALQFLRKNDVMNQTTALDEVPETY
                     EEPDASAVEAIPQKVLMQFINELPAGYRTVFNLYTFEDKSHKEIAQMLGINEKSSASQL
                     FRAKSVLAKKVKEWLVTNG"
     CDS             5545..6297
                     /locus_tag="ctg15_6"
                     /transl_table=11
                     /translation="MKKFNLITFAVILMLLPILQSCLDDANNDEWVTCPPGGILAIGTM
                     KIPNADTPRDFFIALDNGDNVLPADTADIRNRKYTVAEGQRVFVGYLQMGEEKPGYENG
                     KIFTIEDILTKEIIPLTEATADSIGDDRINVTAHALTKDYLTIEYQYLGSMNENKKHML
                     NLVQNEITGPIKDDGYIYLEFRHNAFNDSPNQLGSSLVSFKLDSIAEQLATAKGIKLRV
                     NTIYDNIQYVTIDINEDKNLKIKSFHSQ"
     CDS             complement(6402..7400)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     -3.5; E-value: 38)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg15_7"
                     /sec_met_domain="LysR_substrate (E-value: 9.4e-47,
                     bitscore: 150.8, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 3.9e-18, bitscore: 57.0,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRVKLKISIFALIDSISLINQRTMTIQQLEYILAVDQFRHFAKA
                     AEYCRVTQPTLSAMIQKLEDELGVKLFDRSMTPVCPTAIGKKVLEQARKILSEVICVKE
                     IISEEQHSLSGTFRLAVLPTIAPYLLPRFFPQLMEKYPDLDIRVMEMKTPDIRKALLTG
                     EADAAIIASMLDDAALTEETLFYEQFLGYVSKKEPLFKHDVIRTSDVTGERLWLLDEGH
                     CFRDQLVRFCQMEAVKISQMAYRLGSMETFMHMVESGKGITFIPELAVMQLSEEQKELV
                     RPFAIPRPTRQIVLVTRKDFIRTSLLQVLKEEIQAAVPKEMLTLQAVQCLV"
     CDS             7470..7943
                     /locus_tag="ctg15_8"
                     /transl_table=11
                     /translation="MKTLNYTHLEEKGANTIVLSLQQLLADFQIHYANLRGFHWNIKGH
                     GFFVLHSKFEDLYNGAAEKVDEIAERILMLGGTPANKYSDYLKMAQIKEVDGVNKADDA
                     LNHILETYGHLIAEERKILSLASSHNDEVTVAMMSDYLKEQEKMVWMLTAYNG"
     CDS             complement(8003..9001)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_hydro_130"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg15_9"
                     /sec_met_domain="Glyco_hydro_130 (E-value: 1.2e-69,
                     bitscore: 226.4, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEIKIAGAALPAMPWEERPAGCKDVVWRCSANPIIPRDLLPTSN
                     SIFNSAVVPFKDGYAGVFRCDDTNRRMRLHVGFSKDAVHWDINEEPLKFQCDDAEVGTW
                     VYGYDPRVCFIEDRYYVTWCNGYHGPTIGVAYTYDFVTFHQLENAFIPFNRNGVLFPRK
                     INGRFAMLSRPSDNGHTPFGDIFYSESPDMEFWGRHRHVMSPAPFEDSAWQCTKIGAGP
                     IPIETSEGWLLIYHGVLASCNGFVYSFGSALLDIDQPWKVKFRSGPYLISPQKDYECMG
                     DVPNVCFPCAALHDSETGRIAIYYGCADTVTGLAFGYIPEIIEFTKRTSII"
     CDS             complement(9056..10324)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg15_10"
                     /sec_met_domain="MFS_1 (E-value: 3.3e-11, bitscore: 34.4,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKPISPVCWVPTVYFAMGLPFVALSMVSVLMFSDMEVSNAQIA
                     FWTSLIMLPWTLKPLWSPFLEMFKTKKYFVVATEIITGLAFALVALSLPLPDFFRYAIA
                     LMGIIALSGATHDIAGDGVYLTELTATQQAKYIGWQGAFYNLAKILANGGLVWLAGMLK
                     DEFGVVHAWMIVMLMCAGIMILIGLYHIRILPSGGGASGEVNTMSDALNMLWEVIRSFF
                     QKKHIAFYIVFIILYRFAEGYAIKIVPLFLKASVADGGLGLSTQDIGLVYGTFGAGAFI
                     LGSLLAGYYISAFGLRKTLFSLCCAFNIPFLVYFLLALYQPSDLWIIGMAIVSEYLGYG
                     FGFVGLMLFMMQQVAPGKHQMAHYAFATGIMNLGVMLPGMMSGYLSDWLGYRDFFIWVL
                     IATIPAFIVTWLVPFTYPDGKKK"
     CDS             complement(10574..11587)
                     /locus_tag="ctg15_11"
                     /transl_table=11
                     /translation="MNRHLNFVTLICLITGFVSLASCSNDDDEMDKYQKIYIRTGVAPG
                     AEMGAAVVVDCVSNSSIADRSDFEIQLCAVQPVTRDVTAALGVDTLKVDTYNSANKTKC
                     KLLPQDNYTIETSEVVLKTGQTVADSSFQVVLKNIEKLTNPDGYVLPVTLKGVTGMDEQ
                     AVSTSMKTVYIRIYTSVLYTSYTKPGNWSAVDRSAWSVSCSNVYADDDAKYGAHLAIDG
                     EINTTWFTWGVANAGECWWNTVLDRPVTLTGFSVTKQSAYGSGYNLRSAEIKVRKEGET
                     EWVTYPRVLTFRNFKGADPQYAAIEPPIPNVKEFRINCLTPDNYTGFAEINLYVKQ"
     CDS             complement(11610..12746)
                     /locus_tag="ctg15_12"
                     /transl_table=11
                     /translation="MKRITIKQCLLACFVLPMILAGCNDADYQVIDNAIYLNEASENGS
                     AKVTVDPENVTTTTLTVRVGQPVTENVTAVLTVDPSILKEYNEANETSYEVLPEQYFTY
                     DKEIKIAAGDVSAIPSEFRVKPYSNENGELYAIPVSLTEIQGPVSTIGLSSKFIILLDK
                     PLIQSVPFMNTTNAVKPAKDELWGVTTNEWSLEAWVQMDGFDINNQAIFNSGSSDHEVY
                     IRFGDAMIPYNSLQVKTLGSQVNTVTLFEKNKWYHLAFVYNSSGLLSIYINGVLDVTLQ
                     TKGGPVRFDKMNMVSSGSYFRNNCQMAQVRLWKSAISQTQIQSNMYFAVKPADPNLIGY
                     WKMDEGKGNAFADCTGHGYDLVAGGTLVWKEHVRFDKQ"
ORIGIN
        1 gtacaacggt tttcaagacc gccgcaatcg accactctgc cacctctcca gaactacggt
       61 gaagtagtgc ttttctctta aagcgctgca aaggtacgaa taatttttta acttgcaaat
      121 tattccgcaa aaaaatatta gaaaagtata tttggaagta ataaccgccc tctggcctct
      181 ccccataaat aggtattttt atgctattca acataaaata ggcccctttt atatacctaa
      241 accgaaaaaa ggttgtaaat ttgcgcgctc taaaggataa ctaaccacta actgattaat
      301 tttatggaac tgaataagac ctttaaagat ggactttgga gcaaagaaat caatgtaagg
      361 gatttcgtta gtaataacat cactccttat gaaggggatg cttctttcct gcaaggacct
      421 accgaacgca ccaaagctgt ctggaatcac tgtctcaaag ctctcgaaga agagagaaac
      481 aataatggta ttcgtgcact cgactacaca actgtatcta ctataacctc tcaccctgcc
      541 ggctacatcg ataaagagaa cgaactgatc gtcggactac agaccgatca ggtgttaaaa
      601 cgtgccatca aaccgtttgg cggaatcaat gtggttatga aagcttgccg tgaaaacgga
      661 gtggaagtag atgacagagt taaggatatc ttcactcact atcgcaagac tcacaatgat
      721 ggggtattcg atgtgtatac cgaagaaatt cgttcgttcc gttcattggg attccttacc
      781 ggacttcccg acaactatgc acgcggacgt atcatcggtg attatcgccg cctggctctc
      841 tatggtcttg accgcctgat agaagctaaa aaagaagatc tgcataatct gacaggtcct
      901 atgactgaag cccgcattcg tcttcgcgaa gaaatagccg agcaaatcaa ggccctgaaa
      961 gagattaaag tattgggcga atattatggt ttggatctga gccgaccggc atataccgca
     1021 caggaagctg tacaatgggt gtatatggct tatctggctg ccgtaaaaga gcaggatggt
     1081 gctgccatgt cactgggtaa tgtatcttca ttcctcgaca tctatcttga atatgaatta
     1141 agccagggta cgataaccga aacattcgct caggaactga tcgaccaatt cgttatcaaa
     1201 ctccgtatgg tacgccactt gcgtatgcag tcgtacaacg atatttttgc gggtgatccc
     1261 acatgggtga ccgaatctat cggtggacgt ttcaatgacg gacgtaccaa agttactaaa
     1321 acttctttcc gcttcttgca gacactttat aacttaggcc cgtcaccgga acctaacatg
     1381 actgtactat ggagccctga gttacccgaa ggtttcaaag cattctgtgc acaagtatct
     1441 atcgacactt cttccgtaca atacgaaaac gacgacctga tgcgtgaagt ccgtcaatcg
     1501 gatgactacg gaatcgcttg ttgtgtttca tatcaggaaa tcggaaagca gattcagttc
     1561 ttcggcgcac gtgccaacct tgccaaagcc ctgctactgg ctatcaacgg aggacgttgc
     1621 gaaaatacag gtacagttat ggtaaaagac atccctgtat tgaccggtga aacactgaag
     1681 ttcgaagaag taatggccaa ctataagaaa gtattgatac aaattgcacg tgtatacaac
     1741 gaagcaatga atatcataca ttacatgcac gataagtatt actacgaaaa ggcgcagatg
     1801 gctttcgtgg atactgatcc ccgcattaac ctcgcttatg gtgtagccgg actttcaatc
     1861 gccatcgatt cactgtccgc catcaaatat gcacatgtga aagcccgtcg caacgacatc
     1921 ggactgacgg agggattcga tatcgaaggt gctttccctt gtttcggtaa tgacgatgac
     1981 cgtgtagacc acctgggtgt ggacctggta tatttcttta gcgaagaatt aaagaaactc
     2041 cccgtatata agaatgcccg tcctaccctc tcgctgctga ctatcacttc gaacgtaatg
     2101 tatggcaaga agaccggtgc cactcctgac ggacgcgcca aaggcattgc ctttgctccc
     2161 ggtgccaacc ccatgcacgg acgtgataaa aatggtgcaa tcgcctcact gagttctgta
     2221 gccaagttgc gttatcgcga ctcacaggat ggtatcagca atacattctc aatcgttccc
     2281 aaatcattgg gagcaacaca agaagaccgt atcgacaatc tggtgaccat gatggacgga
     2341 tattttacaa aaggcgcaca ccacctgaac gtaaacgtgc tgaaccggga aatgttgcag
     2401 gatgcgatgg aacatcccga aaagtatccg caactgacta tccgtgtctc aggatatgcc
     2461 gttaatttcg tgaaattgag ccgcgaacat cagttggaag taatcagccg cagtttccac
     2521 gaaagaatgt aattgaatga taaacgtaca ctcatacgag tcaatgggaa cattcgacgg
     2581 gccgggtctc cggctcgtcg ttttccttca agggtgtaac ttccgttgcc tctattgtgc
     2641 caatccggac acaattgaag ccaaaggagg gacagcaacc gaccctgagg aaatagttcg
     2701 catggccgtc agtcagaaag ctttcttcgg taaaaaggga ggtatcacct tttccggcgg
     2761 agagcctact tttcaagcta aatcgcttat cccacttttt aaaagactaa aggaaaaagg
     2821 aatccatatt tgccttgata ccaatggcgg gctatggaac aatgatgtag aggaactatt
     2881 ggaattgact gatctggttt tattagatat caaagaattt aatccggaac atcatcagtc
     2941 tttaaccgga agaagcaacg agcagaccct gaaaactgca gcctggcttg aaaccaatca
     3001 taaaccattc tggttgcgat acgtattagt gcccggctac agtgacttcg aagacgatat
     3061 ccggcagctg ggagagcatc ttggaacgta ccagatgatt cagcgtgtag aaatattgcc
     3121 ttaccacacc ttgggtgttc acaaatatga agcaatgaac aaagaatata tgctgaaagg
     3181 agtgaaagag aatactccgg agcagataga aaaggctgag aaactattca ggcaatactt
     3241 ccggaccgta caagtgaatt gacttatata agtgtcgaaa ttcgtattcg ccacagatta
     3301 cacgaattta cacagataaa gattcattgg caatcaacag attaagttca ctctgcggtg
     3361 aattatgacg attgcgctta tttataattt tgtaagtcac gacataaaaa tctccctgtt
     3421 cttgcctcaa ttcattacaa tacaaggcaa gaacagggag ataatgtaac cggcatattt
     3481 tttgccaccc tactttaata agtgaatcgc aatcctgcct gcaagttaaa gttacaaggc
     3541 ctttcttttc ggatggtttg tactttggag ccatcatcaa agaaatacga aactcccggt
     3601 tccacatata ggccgacatg atctgtcgca ttgaattgcg ctcccacggc accggctaca
     3661 gaaaattgca aaggcttcac attcacctta tcatccgcca actttccata aacacacttt
     3721 tcaaccattc ctccggcaga tacatagagt gtaaaatatt tcttttccag aaaattccag
     3781 tttccacgta caggaatacc tatataatgc aatttctgac tctgcatctt ggtatccccc
     3841 tgccgtttga tgtcagaaga caacaacgta taagtcaatc ccgtctctac agagaaacct
     3901 ttgggaagag acttacgtac agacagtccg aagctaaccg gctgatgatg ttcataatcc
     3961 accacggcag ttgtattgga cttcaggtaa gggacccctt cttcaaatat aacttcctga
     4021 tcggcaggaa tactcacagc tccattcatg atcgtcatca agtcgaccct gttagtcatc
     4081 ggacggggcg caaaaatttc ggaaccattt gtcggaagtc cacctccatt accgataccc
     4141 actcccatcg accatttacc accacgttta gcagaagagt ctccgatagg caactgatac
     4201 ttgtctttac cggacggtcg ccgcgcttct ttcctctttg gaggctgcgc cgtcgcactt
     4261 tcttttttct cgattgcagc agttgcttcc tgttgcggct cagctctctt ttcctccgtc
     4321 actgcctccg gtcgcttctc tgccagggag gatacctccg gaacaatcac cggatcaata
     4381 ttttttgcca aatagcccga aacagggttg atactcgtcg ttcctaccgg cttaacgggt
     4441 tcggatacag ctacctgtac atccggcaag gcaggttccg gcaatacatc cgggttgaca
     4501 gccagtgaag gagccgttgc ataacggatt tcatcagcta ccggactatt cagaaaatac
     4561 aaactgacag cagtcgttac caccaatacc acagctgccg cagcaaccgc ccaccggcga
     4621 tacggatata ttcgtttttc ggttacaggc atcagttccc tttccagtcg ttcccaaccg
     4681 gaagcaggca tcggctccga ataatcttcg agcttatcct tgaatgcttt aatccatttt
     4741 tcgtcttctt tcatcattct atttcatttt tgaaatccaa ggttcacctc agtatctgta
     4801 aatacatgtc aaccattggt caccaaccat tctttcactt tctttgccaa tacacttttt
     4861 gcgcgaaaaa gctgtgaggc agaagatttt tcattaatcc ccaacatctg tgcgatttcc
     4921 ttgtgcgact tatcttcaaa ggtgtataaa ttgaatacgg tacgatatcc ggcggggagt
     4981 tcattaataa attgcatcag cactttctgt ggtattgctt caacagccga agcatccggt
     5041 tcttcatacg tttcgggaac ttcatccagt gccgtggtct ggttcatcac gtcgttcttt
     5101 cttaagaact gtaaagccgt attcaccatt acacgctcca tccatgctct cagagagcct
     5161 tcaccccgcc aggtaaactt gtcgaaggag tcgaaaatct tcaggaaacc gtcgtgtacc
     5221 aagtcttgtg ccatgtccct gtctccggca taacgaagac agacaccaag catgcgccct
     5281 gcgtactgct cataaagttc tttgcgggca cgattatctc cctgcctgca acgttccgac
     5341 agctctaatt cattcattct cctaaacacg tgtttacctt ataaatgcag caaagataga
     5401 aatactgcac agagagaaca actcttttat cacttttgtt tctttaacat tttaggatgc
     5461 aatatttcat cacttcctgc attttctcaa tacaataaag aataaatctc aatggataaa
     5521 taggataaaa ccaacaagaa acttatgaag aaatttaatt taataacttt tgccgtcatc
     5581 ctgatgttat tacccatttt acagtcatgt ctggacgatg ccaacaacga cgagtgggtc
     5641 acttgtcctc cgggtggaat attagccatc ggcacaatga agattcccaa tgcggacact
     5701 ccaagggact ttttcattgc gttggacaat ggagacaatg tacttccggc agatacggcc
     5761 gatatacgca acaggaaata cactgttgca gaaggtcaaa gagtcttcgt tggctatctg
     5821 cagatgggag aagaaaagcc cggatatgaa aacggtaaaa tattcacgat agaagatata
     5881 ttgacgaaag agatcattcc actgacggaa gctacagcag acagcattgg agacgaccgt
     5941 atcaacgtca cagcgcatgc acttacgaaa gattatctga ccatcgaata tcaatatctg
     6001 ggcagcatga atgaaaataa aaaacacatg ctgaacttgg tacaaaacga aataacaggt
     6061 cccataaaag atgacggata tatctatctg gagttccggc ataatgcctt taatgactcc
     6121 cccaatcaat tgggttcgag ccttgtttct ttcaagctgg atagtatagc cgagcaattg
     6181 gcgacagcca aaggaataaa actccgtgtg aacaccattt atgacaatat acagtatgtc
     6241 acaatagata tcaacgaaga caaaaactta aaaataaaat catttcattc tcaataaaac
     6301 aacaagaaac acctacacaa tcaggcaaaa cgagtaataa ttctgataca taaaagaaat
     6361 aaggcggcga tgtttgtgaa aatatcgccg tcgtttttat attataccag acactgaacg
     6421 gcctgcaggg taagcatctc cttgggaacc gccgcctgaa tctcctcttt caaaacctgc
     6481 agcagactgg tgcggatgaa gtctttccgg gtcaccagga caatctgacg ggtaggccgc
     6541 gggatagcaa acggacggac cagttctttc tgctcttcgc tcaattgcat cactgccagt
     6601 tcgggaataa acgtaatccc cttaccactc tccaccatat gcataaaggt ttccatacta
     6661 cccagccgat acgccatttg gctgatctta accgcttcca tctgacaaaa acgaaccaac
     6721 tgatcgcgga agcaatgccc ttcgtcaaga agccaaagcc gttcccctgt cacatcggac
     6781 gtacgaatca catcgtgctt gaacaacggt tccttctttg agacatagcc caggaattgc
     6841 tcgtagaata aggtctcttc cgttaatgcg gcatcatcca gcatgctggc aatgatagca
     6901 gcatccgctt caccggtcag cagagccttg cgaatgtcgg gcgtcttcat ctccatcacc
     6961 cgtatatcaa gatccgggta tttctccatc agttgcggaa agaaacgggg cagaagataa
     7021 ggtgcaatcg tcggtaacac tgccaatcgg aatgtacccg acagggagtg ctgttcttcg
     7081 ctgatgatct ccttgacaca gataacttcc gaaagaatct tacgggcctg ttccagcact
     7141 ttcttaccaa tggcagtagg gcaaaccggt gtcatgctac ggtcgaacag tttcaccccc
     7201 aattcgtctt ccagcttctg gatcattgca ctcaaagtag gttgcgtcac ccggcaatac
     7261 tcggcagctt tagcaaaatg ccggaactgg tcgacagcca gaatatattc caattgttgt
     7321 atagtcatcg ttctctgatt tattaaagat atagaatcta tcaatgcaaa gatagaaatt
     7381 ttcagtttga cacgaatcat tttgtgccgt atctttgttc cagataaaaa gaagaaatat
     7441 agtattaact caaaaaaaac aatatcatta tgaagacttt aaattataca catttggaag
     7501 aaaaaggagc taacaccatc gtactgtcat tacagcaact gcttgccgat tttcagattc
     7561 attatgcaaa cctgagagga tttcactgga acatcaaagg acacggtttc ttcgtactgc
     7621 acagcaagtt tgaagattta tataacggag ccgccgaaaa ggtggacgaa atagccgaac
     7681 gtatactgat gctgggagga actcccgcca ataaatacag tgactatctg aagatggcgc
     7741 agatcaagga agtggacgga gtgaataagg ccgacgacgc tctgaatcat attctcgaaa
     7801 cttacgggca tctgattgcg gaagaacgta aaatcctgtc tctcgcctct tcacacaacg
     7861 acgaagtaac agtggccatg atgagcgact acctgaaaga acaggaaaag atggtttgga
     7921 tgctgactgc atacaacgga taacagccga aagggtgtag ccatcccggc gggatagcta
     7981 cacccttcct gttttattcg attcagatga tacttgtacg tttggtaaat tcaataatct
     8041 ccggaatgta tccgaatgcg agcccggtca ctgtatccgc acacccataa tagatggcaa
     8101 tccgtccggt ctccgaatca tgaagcgccg cgcatgggaa acagacatta ggcacatcac
     8161 ccatacattc gtaatccttc tgaggtgaaa tcagataagg ccccgaacgg aattttactt
     8221 tccagggctg atcgatgtca agcagtgccg aaccaaaact atacacaaaa ccgttgcagg
     8281 aagccaatac accatgatag atcagtaacc agccttccga ggtttcaatc gggataggcc
     8341 ctgcaccgat cttggtacac tgccaggcac tgtcttcgaa cggagccggc gacataacat
     8401 gacgatgacg tccccagaac tccatatcgg gagactcgct atagaaaata tctccaaaag
     8461 gagtatgccc attatcactc gggcggctca acatcgcaaa acgaccgttt atcttacgag
     8521 ggaacaagac tccattccga ttgaagggaa taaaggcatt ctccaactgg tgaaaagtaa
     8581 caaaatcata ggtgtaggcc acaccgatag taggaccgtg atagccatta caccaggtca
     8641 catagtagcg gtcttcgata aagcaaaccc gtgggtcata tccatagacc caggttccaa
     8701 cctcagcgtc atcacattga aactttaacg gttcttcgtt gatatcccaa tgaacagcat
     8761 ccttgctgaa tcccacatgc aaacgcatgc gacgattagt atcatcacaa cggaacaccc
     8821 ctgcatagcc atccttaaac ggaactacgg cactgttgaa tatactgttt gaagtaggga
     8881 gcaagtcgcg cggaataatc ggattggccg aacaacgcca cactacatct ttacatcctg
     8941 ccggacgttc ttcccaaggc atagccggca aagcagcacc tgcaatttta atttcttcca
     9001 tgattcgatt aaattaatat tatgtatata tcttgtttat attgaaaatc tctttttatt
     9061 tcttctttcc gtccggatat gtgaaaggta ccagccaagt cacgataaaa gccggtatgg
     9121 tagcgataag tacccagata aagaaatcgc gataacccag ccaatcgctc aggtatccgc
     9181 tcatcattcc gggaagcatc acccccagat tcataatacc ggtagcaaaa gcataatgtg
     9241 ccatctgatg tttgccggga gccacttgct gcatcataaa gagcatcaat ccgacaaaac
     9301 caaacccgta acccaagtat tcagacacaa tggccatacc aataatccat agatcggaag
     9361 gctggtaaag ggctaacagg aaatatacca agaacggaat attaaaagcg caacataaag
     9421 aaaacaaagt cttccgaagt ccgaaagccg aaatgtaata accggccaaa agcgaaccga
     9481 gaataaaagc tcccgctccg aacgtaccat ataccagtcc gatatcctga gtgctgagtc
     9541 ccaatccacc atccgcaacc gacgctttca ggaacaacgg tacaatcttg atggcatatc
     9601 cttcggcaaa ccggtacaaa atgataaaga caatgtagaa agcaatatgt tttttttgga
     9661 aaaaagagcg gatgacttcc caaagcatat tcaatgcgtc actcatcgta ttcacttcac
     9721 cggaagcgcc tcctcccgaa ggcaaaatcc ggatgtggta aagaccgatc agaatcataa
     9781 tacccgcaca catcaacatg acaatcatcc aggcatgtac cactccaaat tcatccttca
     9841 gcatacctgc cagccaaacc aagcctccgt tggcaagtat cttggccaga ttataaaaag
     9901 ctccctgcca accgatatac ttggcttgct gggtagcagt cagttcagtc aggtatactc
     9961 cgtcacccgc aatgtcatga gtcgcaccac tgagagcaat gatccccatc agagcgatgg
    10021 cataacgaaa aaagtcgggc agcggcagcg aaagtgctac caatgcaaat gccagtccgg
    10081 taatgatttc cgtagcgaca acaaagtact ttttcgtttt aaacatttcc agaaacggac
    10141 tccataaagg cttcaatgtc cagggaagca taatgagaga agtccagaaa gcaatctgtg
    10201 cattcgacac ttccatatcg gaaaacataa ggacagaaac catcgaaagg gccacaaacg
    10261 gcaatcccat agcaaagtaa acagtaggca cccaacatac agggcttatc ggctttttat
    10321 tcatcagtta gttttttata ataattccat cggttaacaa ttccagtaag caaagatagg
    10381 ggatattaaa aacataaccc aagattacga caagaagttg ctttcattat ttaataatac
    10441 aactcacccg ggaaaactac taacctctat cacccttttt ttattaaact ttatcaatac
    10501 aatacacgca aagaagcacc gaagactttc atccccgatg cctctcgccc ccttatctac
    10561 aatctaaaca cctctattgc ttcacatata aatttatctc agcaaacccg gtataattat
    10621 ccggagtcag acagtttatt ctgaattcct ttacattcgg gataggtggt tcgatggccg
    10681 catattgcgg atcagcccct ttaaaatttc tgaaagtcaa gactctcggg taagtaaccc
    10741 actcggtttc accctctttc cgaaccttaa tctcagcact tctcaggtta taacccgatc
    10801 cgtaggcact ctgtttagtg accgaaaatc cggttaaggt aacaggccgg tccagtaccg
    10861 tattccacca acactctccg gcattagcca ctccccatgt aaaccaagta gtatttatct
    10921 caccgtcaat agccagatgt gcaccatatt tagcatcatc atcggcataa acattgctgc
    10981 aacttacact ccacgcactt cgatctacag cggaccaatt cccgggtttc gtataactgg
    11041 tataaagcac gctggtataa atccggatat aaaccgtctt catagatgta ctgacagcct
    11101 gttcgtccat gcccgtaact cctttaagcg tcacgggaag cacatatccg tcaggattag
    11161 tcaacttttc tatattcttc aaaacgacct gaaaagatga atcggccact gtctgtcccg
    11221 tttttaagac aacttcactt gtttcaatgg tataattatc ttggggcaac aacttacatt
    11281 tcgtcttatt ggcagaattg taagtatcca ctttcagcgt atctactccc aaagcggcag
    11341 tgacatcccg cgtaaccggc tgtacggcac acaattgtat ttcaaaatca gaacggtcgg
    11401 caatagagga attgctcaca caatccacca ctaccgcagc acccatttcg gcccccggtg
    11461 caactcccgt tctgatatat atcttttgat atttgtccat ttcatcatca tcgttgctgc
    11521 acgaagccaa cgatacaaag cctgttatca ggcagattaa ggtcacaaaa ttcaaatgtc
    11581 tattcatatc ttatcttctt tttacatagt tattgcttat caaaacgaac atgctctttc
    11641 cagacaagag ttcctcctgc caccaaatcg tatccgtgtc cggtacagtc ggcaaaggca
    11701 tttcctttac cttcatccat tttccaatag cctatcaggt tcggatcggc gggtttcacg
    11761 gcaaaataca tgttggactg aatttgcgtc tggctgattg cgctcttcca aagacgcacc
    11821 tgggccatct gacaattgtt gcggaagtag ctaccgctcg aaaccatgtt catcttgtcg
    11881 aatcttaccg ggccaccctt tgtctgcaga gtcacgtcga gcactccgtt gatataaatc
    11941 gacaataacc cggaagaatt ataaacgaag gccagatgat accacttatt cttctcaaac
    12001 aaagtcaccg tattgacctg acttccaagt gtcttcacct gtaatgaatt ataagggatc
    12061 atagcgtcac cgaaacggat ataaacctcg tggtcgctgc tgcccgaatt aaatatagcc
    12121 tgattattaa tatcgaatcc gtccatctgt acccaagcct cgagtgacca ttcattggtt
    12181 gtcactcccc acaattcgtc cttggcgggc ttcacggcat tggtcgtatt cataaacggt
    12241 acagactgta tcagcggctt atccagcaaa atgataaact tcgacgaaag cccgattgtg
    12301 gacaccggtc cctgaatttc tgtgagagat accggaatag catacaattc tccgttttcg
    12361 tttgaataag gtttcactct aaactcactg gggattgcgc taacatcgcc tgccgctatc
    12421 tttatctctt tgtcataagt aaaatactgc tcgggaagga cttcgtacga agtttcatta
    12481 gcttcattgt actctttaag aatagaagga tctaccgtca ggacagcagt cacattttcg
    12541 gttacaggct gtcccacacg tacggtcaga gtagttgttg ttacattttc aggatcaacg
    12601 gtaacctttg ccgaaccatt ctcggatgct tcattcaaat aaatcgcatt gtcgataacc
    12661 tggtaatcgg catcgttgca tcctgccaag atcatcggca gaacgaaaca ggcaagcaaa
    12721 cattgtttta ttgttattct tttcataatc aaattcttta aagtcatttt acagcaggat
    12781 tcattattct gattgcttca cgcaggtact tatattcgat gtcgcccgga tagtcatatt
    12841 ccatgtgata ggtgcctact ccacccttcc gtacctgttt tccgtcaata gtcggagtcc
    12901 agcgtgccat gccggcaagt gctctcattt tgtttccgta acgatctaca taatcacctc
    12961 ctcctgtcgg agcataagat tcgaaattct ccgtaacgat gtacatatta gccactttct
    13021 ccggaggaag tattccttta aagttggcaa tcgtaccagc cagacgtctg tcaagattag
    13081 cgtcggaatt acccgcaagg ttagagtatg cctgcacaat gaaatagtca aagtaaggcc
    13141 cggtttccgg atgaatactt tgaggctcgc catcaatcac aagtaaccgt cccgtacccg
    13201 atttaggtcc gattctttct cccagtgctt tcacgaaagt gagcatattc tcgggataac
    13261 tc
//
