LOCUS       gnlProkkaCGIMHHCM_362  12090 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CGIMHHCM_362.
ACCESSION   gnlProkkaCGIMHHCM_362
VERSION     gnlProkkaCGIMHHCM_362
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 13:53:36
            Original ID  :: gnl|Prokka|CGIMHHCM_362
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12090
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..306
                     /locus_tag="ctg362_1"
                     /transl_table=11
                     /translation="MTAKVHIILKGAYSAIITPEGKCYFNQTGNPGMATGGSGDVLTGV
                     ILALLAQGYPAEDAAKIGTYIHGLAGDIAQKKQGMIGLIASDIVTCLPTAWRLVSE"
     protocluster    1..12090
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[1742:2090]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1743..2090
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..12090
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12090
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             380..1444
                     /locus_tag="ctg362_2"
                     /transl_table=11
                     /translation="MKKLIIATGLLMATSAYAQTEVLTGVTRGKDYGVVYALPKTQIEI
                     EIKANKVNYKPGEFSKYADRYLRLTNVSAEPEEYWELNSVKVKPVGVPNSEATYFVKLK
                     DKTVAPLMELTEEGLIKSINVPYSSNNAKNAANNAVAPQRKANPRDFLTEEILMASSTA
                     KMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNLQEEAMTEMFSGVRNK
                     EEKTFTVRLTPDKEFDNEVAFRFSKKLGIVANNDLAGTPFYISLKDLKTVKIPQEDGKK
                     KKEMEGIAYNVPGQAMVTLTDGKKKLYEGEIPVTQFGIIEYLAPVLFNKNSTIKVYFDP
                     VTGGLLKVDREESK"
     CDS             1466..1753
                     /locus_tag="ctg362_3"
                     /transl_table=11
                     /translation="MGGEGHMLDMIRRLKDGKEASRLRRERRNDKLGRLRRNNDPYLLP
                     DTTPEEMERIIKDSEKKKEKDNSYFVWGTLIIMGVLIGCAVLLWAIFFNG"
     CDS             complement(1743..2090)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg362_4"
                     /sec_met_domain="PF05402 (E-value: 2.8e-17, bitscore: 53.8,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PqqD_RRE (E-value: 1e-09, bitscore: 29.0,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATKEKINLLEVIPCRNEHIKAEQEGETIVLSFPRFKRSWMSRYL
                     LPKGMSKDIHVRLEEHGTAVWNLIDGQRTVREIIEKLADHFQYEAGYESRVSTYLSQLQ
                     KDGFIKWIIIH"
     CDS             complement(2135..3523)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 90.5; E-value: 1.4e-27)"
                     /gene_kind="transport"
                     /locus_tag="ctg362_5"
                     /transl_table=11
                     /translation="MTEQLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AITTTFPEGAMLFGFKMQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGVFHTNIPAPILFCLVMLCVGTIAFFIYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMVIGSVMLIFVHTMFAL
                     PILNIWWFATVIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNSYCKGPVVDGAQTYDYTLPMAIFAMFGVLALIVALMLKVENKKKGYGLEEA
                     NIQK"
     CDS             complement(3814..4209)
                     /locus_tag="ctg362_6"
                     /transl_table=11
                     /translation="MYLLFIILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSVATAYVVPSSSAAKDVLLEQAQKEQQTNPYNMPTGTAAP
                     QTDATAPAESAPATEAPATETPAPVAE"
     CDS             complement(4216..4989)
                     /locus_tag="ctg362_7"
                     /transl_table=11
                     /translation="MTSVNLQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSYLLEETPATEQPAEETPKLKGYELIDDFIEK
                     SESDSPLCKKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             complement(4994..5521)
                     /locus_tag="ctg362_8"
                     /transl_table=11
                     /translation="MNWIKKIARPLILVVLPAVIIACSVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPNQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSSQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             complement(5508..6749)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 388.8; E-value:
                     6.1e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg362_9"
                     /transl_table=11
                     /translation="MTKAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPLPTQARLLRVLESGEFIKVGSSKVQKTDVRIVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFAADFAEKYRMPAIQLTEDAKKI
                     LLAYPWPGNVRQLKNITEQISIIETNREITAAILQTYLPAQNTQRLPALFGTRESKSFE
                     SEREILYSVLFDMRQEVAELKKMVHNMMAERAGQVGQMGQVVATPVVTTTHQPSVPAII
                     HAVQQPSVCPKEDDDDIQDTEEYVEETLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             complement(6873..7967)
                     /locus_tag="ctg362_10"
                     /transl_table=11
                     /translation="MEENKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDVQANFSIVNTASEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGHGNKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEIIIPAMKEMEEKGIICYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGLASEDSFRQAIYVAIDVFRNRQREKAARVN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             complement(7972..9009)
                     /locus_tag="ctg362_11"
                     /transl_table=11
                     /translation="MKKYFFYLSMALVAFVVASCGLKGNHTSSGRPYELLVVVDAGVWD
                     RAAGRALHDVLDSDMPGLPQSEPSFRIMYTSPKDYDSTLKLIRNIVIVDIKDIYTKGTF
                     KYAKDVYASPQMILTIQAPNEEVFEKFVEENKQTIIDFFTRAEMNRQITLLEEKHNNFI
                     SNKVDSLFDCDIWIPSELNNSKTGEDFFWASTNTGSADRNFVMYSYPYTDKDTFTKEYF
                     VHKRDSVMKANIPGYKEGVYMSTDSLLTDVRPINVHNDYTMEARGLWRMKGDFMGGPFV
                     SHTRLDQKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPQEGQQSQIPLGVTREA
                     EPTNK"
     CDS             complement(9027..10064)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg362_12"
                     /sec_met_domain="PF04055 (E-value: 2.3e-17, bitscore: 54.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMSKYPLLGMTLIELQSLVKRLGMPGFAAKQIASWLYDKKVTSID
                     EMTNLSLKYRELLKQNYEVGAEAPVEEMRSVDGTVKYLYPVGENHFVESVYIPDDERAT
                     LCISSQVGCKMNCKFCMTGKQGYSANLTAHQIINQIHSLPERDKLTNVVMMGMGEPLDN
                     LEEVLKALDILTGSYGYAWSPKRITVSTVGLRKGLRRFIEESDCHLAISLHSPVTAQRA
                     ELMPAEKAFSITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCR
                     INLIRFHSIPGVALEGADMDMMTRFRDYLTTHGLFTTIRASRGEDIFAACGMLSTAKQE
                     ENNKS"
ORIGIN
        1 cacactgcca aagtacatat cattctgaag ggagcttatt ccgccattat cacccccgaa
       61 ggcaaatgtt acttcaacca gaccggtaat cccggtatgg caacaggagg cagcggagat
      121 gtactgacag gagtaatcct tgcactcctt gcgcaaggct atcccgccga agacgccgca
      181 aagatcggta cttacattca cggattggcc ggagacatcg cccagaaaaa acagggcatg
      241 atcggattaa tcgcaagtga tatcgtgact tgtctgccga cggcatggcg acttgtaagc
      301 gaataaaagt taagaactta cggtttattc aataacttca ttaactttgt ttttcaaaat
      361 cagctaaaaa gaaccgaata tgaaaaagtt aatcatagca acaggactac taatggcaac
      421 ttccgcctat gcgcagaccg aagtgctgac aggagtgacg cgaggaaaag actacggagt
      481 agtgtacgcc ctccccaaaa cccagataga aatagaaata aaagcaaaca aagtcaacta
      541 taagccgggt gaattcagca aatacgccga ccgctacctg agactgacca acgtctctgc
      601 cgaacccgaa gaatactggg aactgaacag tgtcaaagtg aaacctgtag gtgtaccaaa
      661 cagcgaagct acttatttcg tcaaactgaa agacaaaacc gtagctcctc ttatggaact
      721 gactgaagag ggtcttatca aatcaatcaa tgtcccctac agcagtaaca atgcaaagaa
      781 tgcagcaaac aatgccgttg ctccccaacg aaaagccaat ccccgcgact ttctcacaga
      841 agaaattctg atggcaagtt caaccgccaa gatggccgaa ctggtagcaa aggaaatcta
      901 taatatccgc gaaagtaaaa acgcattatt gcgcggacaa gcagataata tgccttcgga
      961 cggcgcacag ctcaaaatca tgctcgacaa cctgaatctt caggaagaag ccatgaccga
     1021 gatgttttcg ggagtccgca ataaagaaga aaagacattt actgtccgcc tcactccgga
     1081 taaggaattc gacaatgagg tagctttccg cttttcaaag aagctgggta tagttgccaa
     1141 caacgatttg gcaggcactc cattctacat cagtctgaaa gacctgaaaa cggtgaagat
     1201 tccgcaagag gacgggaaaa agaagaaaga gatggaaggc attgcttata acgtaccggg
     1261 acaggcaatg gtgacgctga cggacggcaa aaagaaattg tatgaaggag aaatacctgt
     1321 tactcagttc ggtatcatag aataccttgc tccggtatta ttcaacaaga actcgaccat
     1381 caaagtttac tttgatccgg tgaccggtgg actactgaaa gtagatagag aagaaagcaa
     1441 ataaaacctc taaaaaaaca aaacgatggg tggcgaagga catatgctcg acatgatacg
     1501 tcggctgaaa gacggcaaag aagcctcccg cttacgccgt gaacggagaa atgacaagtt
     1561 agggcgactt agaagaaaca acgaccctta tcttctgccg gatacgactc cggaagagat
     1621 ggaacgcatc atcaaggatt cggaaaagaa aaaagaaaaa gataacagct atttcgtatg
     1681 gggaacgctt atcattatgg gcgtactgat aggatgtgct gtcctcctgt gggcaatctt
     1741 ttttaatgga taattatcca tttaataaat ccgtctttct gtaattggga aagataggta
     1801 gatacacgag actcgtagcc tgcttcatat tgaaagtggt ctgcgagttt ttctataatc
     1861 tcacgaaccg tccgctgccc gtctatcagg ttccatacgg ccgtaccgtg ttcttccaga
     1921 cgcacatgaa tatctttgga cattcctttc ggcaataaat aacgactcat ccacgaacgt
     1981 ttaaaacgag ggaaggagag cacaatagtc tccccttcct gttcagcttt aatatgttcg
     2041 ttacgacaag gtatcacctc caggaggttt attttctctt tcgtagccat atcttttctc
     2101 ttttatatct tttcagatag aatatatact gtgattattt ctgaatattt gcttcttcca
     2161 gtccgtagcc tttcttcttg ttttccactt tcagcatcaa ggcaacaatc agggcaagta
     2221 caccgaacat agcaaaaata gccatcggca aggtataatc ataagtctgt gcaccatcta
     2281 caaccggacc tttgcaataa gagttcaaca cccatccgat cagcaaaggc acgcccatca
     2341 atccccagtt ctgtacccaa aagatcaacg cataagccgt tcccaactgt ttctccggaa
     2401 taatcttcgg aaccgaaggc cacattgccg aaggaaccaa tgagaaagca aatcccagaa
     2461 taatcatgat caccgttgca aaccaccata tattcagaat aggaagagcg aacatcgtgt
     2521 gtacgaaaat cagcatcacc gacccgatca ccatcagcgt ggctccctta ccgatacggt
     2581 catataatga accgaacaat ggtgtcagga tgatcgcgcc aatcggcagc aatccgggaa
     2641 tcgttcccgc aagtttcgga tcaacattgt acttctgtac catcaaatcg gccgcatact
     2701 tgatgaaggg gaatacagcc gaatagaaca atacgcacag taatgcgatc agccagaatc
     2761 ctttgttggt aatgatatag acaatgtctt tcatgcggaa aggttcttcc ggttccagtc
     2821 cttccgcatc cagtgaagca tccagtttct tatcgtagaa agtatagatg aagaatgcga
     2881 tggtacctac gcacaacatg acgagacaga acagaatcgg agcgggaata ttggtatgga
     2941 atacgccgct ctcatccgta gacccgaaga agtctgccaa aggaacggta agcaccatgg
     3001 ccaaagttgt tccaatacgc gcggtcgcca tttccagtcc catagcgaga gccatctctt
     3061 tgcctttaaa ccacttcacg ataatcttcg aaacggtgat acccgcaatt tcgactccta
     3121 caccgaaaat agcataaccc aatgcagcca atgtgacttg catcttgaat ccgaaaagca
     3181 tcgcaccttc cgggaaagta gtagtaatag cataatattt caatccacaa ccgaacacca
     3241 tcaataaaca ggcacccatt ccggtgaagc gtactcccat cttatccaga atgataccac
     3301 caaagatgag catcagcagg aatacattaa accagccata agcactggtg aaaaaaccgt
     3361 aatctaaact gtcccagaga agttcttttt caagcatggg tttcagagga gacataacgt
     3421 ctgtgaggaa gtagccgcac aacatggtaa aagcgactaa tgctagaaca ctccaacgca
     3481 gcactgcgga gtcattcagc ttttgtttca attgttctgt cattgtaata tttaaaagga
     3541 gttaataatc tcgtaacggg caacaaagtt aactaattat catttgtttt actaaaaaag
     3601 gagaacattt tataagaaaa aggacatctg accggatatt cctgtatgaa gaagagcaga
     3661 ccgggcccaa taataaagac agacgcgaac tacacgtatt acacgattct attagaatct
     3721 cttgtaattc gcgtaattcg cgcctataat gaagagaacg ggtcaaaaag cccgttcact
     3781 caataagttt aaaccgaata tcctgtcact gaattattct gctacaggag caggagtttc
     3841 agtagccgga gcttccgttg ctggtgcaga ctctgcagga gcagtagcat ctgtctgagg
     3901 agcagcagta ccggtaggca tattatacgg gttggtttgt tgttctttct gtgcttgttc
     3961 caacaataca tctttagctg cagaagaaga aggaacaacg taagcagtag caacgctcat
     4021 cacaaccatg aagatagcca gaccccaagt tgctttttcc agaaaatctg tagtcttgcg
     4081 cacgcccatg atagcgtttg atgaagaaaa accagaagca agtccgcctc cttttgaatt
     4141 ctgaatcagc acgatgaagc acatcagcaa ggctgcaatc accattaaga taatgaataa
     4201 taagtacatt tttagttatt ttgaattagc gttaataatc aatttctcca aaaatctgat
     4261 ttggtctgca aagtaagcat ttttttttgg atatttcaag cttaattttt taattatttc
     4321 aagagctttt gaatatcgtt gctgtttaac atagattttt gccaaagttt ccgtaaaaca
     4381 gctgtcatct tcctcttctt ccttcatcgt ttcttcttcg gtaagttcgt ccgaagaggt
     4441 tggcgaagat ggcatttctt ctcttaaagg tttcttgcag aggggagagt cgctctcgct
     4501 cttttctata aagtcgtcaa tcagttcgta gcctttgagt ttgggcgttt cttcggccgg
     4561 ctgttccgtg gccggagtct cctccaaaag ataagaggtg taatccatcg aatagtcgaa
     4621 gctggtgcgg gcagtcacct cttcgggtac tgtggacaag aaagcgtcga tcaatgctaa
     4681 tgtgcggtct acggacggtt cgtctttcag cacctccgtg agaggtactc cctttttccg
     4741 tgcctgcaca tcatagcggt caccttcaat caaccggaac aactgccgtc tgtctgcaat
     4801 gtaaagaact gctttccgca gttctccacc aaaactaata tcatggagaa tatacagatt
     4861 cttcagatac agcagacgaa gtgactgaaa atacggatac ctcgcaagaa gattgcgcag
     4921 ttcgtacaaa gtatccctat tcagcgtctc gggatgctga atccattgtt gcaagttaac
     4981 agaagtcatt aaattaccag tttgctacag ttgcattaaa tatttggtcg gttatctctt
     5041 tactcatttc cgctattaat ccatcctgta cggctgtcag cagctggctg gaatcatagg
     5101 tacggaaagc tgagaattgt tgttcgaagt cttcggcgtg atttgtgttg ttgacaaagc
     5161 gtacattgac cgtgatggtc agcttcgttt ccgaagagta accatcggca gacactgcct
     5221 ggttatactg gttgtagccc gtaatttcac cgtcaatctg cagatccgca ttctggttcg
     5281 gtttcagcag ttgcagacgg gtctgtctga tgaagatatc tttcaggtct tcattgaact
     5341 tggtagccag cggagcatac acatactccg acttaatcgg gaaatcagca atcgaaatag
     5401 tcttcacctt atcgtaattg atagaggagc cattaaactt ataggacaca ctacaggcga
     5461 tgatgactgc cggtaaaaca accaatatca gcggtcgtgc tattttctta atccaattca
     5521 tattctttta tttttctgta aagggtacgc tcggagatat tcagatcctt cgccgcactt
     5581 ttccgcttac catgatgcct ctcaagcgct ttacgtatca tttctttttc cacttcatcg
     5641 agcgaaaggg tttcttccac atactcttcc gtgtcctgaa tatcgtcatc gtcttctttg
     5701 ggacaaacag acggttgctg cacagcatgg attatggccg gcacggaagg ttggtgcgtc
     5761 gttgtcacta ccggagtagc tactacctgt cccatctgtc cgacttgtcc cgcacgttcg
     5821 gccatcatat tgtgcaccat cttcttcagt tccgccactt cctgacgcat atcgaacaag
     5881 acagaatata gtatttcgcg ttcgctctca aagctcttgc tctcgcgtgt gccgaacagt
     5941 gccggaaggc gttgggtatt ctgtgccgga agataggtct gcagaatcgc agccgttatc
     6001 tcacggtttg tttctataat cgaaatctgc tctgtgatgt tcttcaactg ccggacgttt
     6061 cccggccacg gataagcaag caatatcttc ttggcatctt ccgtcagctg gatagccggc
     6121 atccggtact tttcggcaaa gtctgcggca aacttacgga acaacaacag cacatcatct
     6181 ccacgctcac gcaaaggtgg tatctgaata ggcaccgtgt tcaaccgata atacaaatct
     6241 tcccggaagc gtccttcggc aatggcttgt gtcaggttca cgttggtcgc tgccacaata
     6301 cgtacatccg tcttttgcac tttggatgaa cctaccttga taaattcacc gctttcaagt
     6361 acacggagca gacgcgcctg tgtaggcaac ggcaactctc ccacttcatc aaggaagata
     6421 gttccaccgt cagcttctcc aaaatatcct ttccgctcac caatagcacc ggtaaatgct
     6481 cctttctcgt gtccgaacag ttcggaatcg atcgtacctt ccggtatggc accacagttg
     6541 acagcaatat actgcccatg ctttctccgg ctatattgat gaatgatctg tggaaaactt
     6601 tcttttccga caccactttc tccggtaatc agcacagaca aatcggtagg cgctacctga
     6661 atggcaacat ctatggcacg tgataaagcc tcggtattgc caataatacc gaaacgctgt
     6721 ttcacttgtt gtatctccgc tttggtcatc tatcttaata ttaagtaata ggtaataagt
     6781 attaagtaat aagtattaag tattaccatc attatcatct cgcttccatc cgcatggcta
     6841 atacttaata cttattactt aatacctatt acttaatctt cgtctactgt atccagtttt
     6901 agtttatcac tatcgtcccg cttctcgtaa tactgcttcc gcaacgggtt tacccgtgcc
     6961 gctttctcgc gctggcggtt gcggaataca tcaatcgcta cataaatagc ctggcggaaa
     7021 gagtcttcgc tggccagtcc tttaccggcg atgtcatagg ctgttccatg agccggagag
     7081 gtacgtacaa ccggcagtcc ggcggtatag ttcacaccgt cttccatagc cagggctttg
     7141 aacggagcca gtccctgatc atgatacata gcaaggattc cgtcaaagtg agtataattg
     7201 cccgaaccca taaaaccgtc cgcagcataa ggaccgtaac agatgatccc tttctcttcc
     7261 atttctttca tggcagggat aatgatttcc tgttcttcca tacctagcag tccgccgtct
     7321 cctgcatgag gattcagtga aagcactgca atacggggcg caccgatacc gaaatcctgt
     7381 ttcagacaac gatggaaaat catcagcttt tcctgaatca gttccttggt gattgttgta
     7441 gcaatctccc ttaccggaat atgcgtcgtt actaaagcca cacgaaaatc gtttttcatc
     7501 aagatcatca gtgacttgtt tccatggccc agacgttctt caatatactc cgtatgcccg
     7561 gggaaagaga actcttccga ctgaatggta tgtttgttga tcggagctgt cacaatgacg
     7621 tcgatcagcc cctcacgata ctcttctatg gcacgctcca aagcacccaa tgcagcctta
     7681 cctgcttcgg gatcgggttt ggagaattcc actttcactt cgtcatctgt acagttcact
     7741 acactcagac ggttgtatcc ggcttcggaa gctgtgttga caatgctgaa attagcctgt
     7801 acatccagtg ctttacgatg gtaagccgct actttaggtg aaccgtagat aatcggagta
     7861 catagctcaa gcatggtagg gtctgagaat gtcttcaaga tcacttcata acctaccccg
     7921 ttgatatctc cttgggtaat gccgattctt attttgtttt cttccatgtt tttatttatt
     7981 agttggttcc gcttctctgg ttacccccag tggaatctga ctctgctgac cttcttgcgg
     8041 aagtttcagc gtataaagag atgcttccat ctggcgaacc agattgcgtt tcattttatc
     8101 gggtgaatat acaaatattt ctgctgtaat aatacgttgg ttcttctgat ccagacgagt
     8161 atgggaaacg aacgggccac ccatgaagtc acccttcatg cgccacaatc cacgagcttc
     8221 catcgtgtag tcattgtgca cgttgatcgg acgaacatcg gtcagtaacg agtctgtcga
     8281 catatatacg ccttctttat atccggggat attggctttc atcacagaat cgcgcttatg
     8341 aacaaagtat tctttggtga atgtatcctt gtcagtataa ggataagaat acatcacgaa
     8401 attgcgatcc gcgctgcctg tattggtaga tgcccaaaag aagtcctctc ctgtcttgga
     8461 gttattcagt tcggaaggta tccagatatc gcagtcaaac agactatcta ccttatttga
     8521 gataaagttg ttgtgctttt cctccagcaa agtaatctga cggttcattt cagcgcgagt
     8581 gaagaagtcg ataatcgtct gcttgttttc ttcgacaaac ttctcaaaca cttcttcgtt
     8641 cggagcctga atggtcagta tcatctgtgg agaagcataa acgtctttcg catacttgaa
     8701 agtacctttg gtataaatat cttttatatc tactatcaca atattacgga tcaacttcag
     8761 cgtagaatca tagtccttcg gtgaagtata cataatccgg aaagaaggtt ccgactgggg
     8821 cagtcccggc atgtcagaat caagcacatc atgcaaggcc cttccggcgg cacggtccca
     8881 cactcccgca tctactacaa ccaacagttc atacggacga ccgctagagg tatgattccc
     8941 ctttaatcca caagaagcaa ctacgaaggc taccaaagcc atgcttaaat aaaaaaagta
     9001 ctttttcatg atgttcgatt tttatattaa cttttattat tttcctcctg tttcgcagtc
     9061 gacagcatac cgcatgccgc aaaaatatcc tctccccgcg aagcacgaat ggtagtgaaa
     9121 agcccgtgcg tagtcagata gtcacggaaa cgggtcatca tatccatatc ggctccttca
     9181 agggctactc ccggaataga atggaaacgg atcaggttaa tccggcaatc cagtccgcga
     9241 agcagtttga gtaactcctt ggcataaact tgcgaatcat taagcccctt aaaaacaata
     9301 tattcaaacg aaagtcgacg ctgtttgcta aaatcatagt tttttaacag ttccaccatt
     9361 tccgtgatag aaaaggcttt ctccgccggc atcagttccg cacgctgggc ggtcaccgga
     9421 gaatgcaggc tgatggcaag gtgacagtcg ctttcttcga taaagcgccg caatcctttc
     9481 cgcaatccga cagttgaaac ggtaatccgc ttcgggctcc atgcataacc ataggaccct
     9541 gtcagtatgt ccaatgcctt caacacctct tccagattat cgagcggttc gcccattccc
     9601 atcatgacga cattcgtcag tttgtcccgt tccggcaagg agtgaatctg attgataatc
     9661 tgatgggcag tcaggttggc agagtagcct tgtttcccgg tcatacagaa cttgcagttc
     9721 attttgcagc ctacctgtga agaaatgcat aaagtcgccc gttcatcatc cggaatatac
     9781 accgactcca caaaatgatt ctcgcccaca gggtacaggt atttcaccgt accgtctaca
     9841 gagcgcattt cctccaccgg agcttcagct cctacctcat agttctgctt cagtaactcc
     9901 cggtatttca acgacaagtt agtcatttca tcaatcgaag tcaccttctt atcataaagc
     9961 caggatgcaa tctgtttggc tgcaaagccc ggcattccca gacgtttcac cagtgactgc
    10021 agctctataa gcgtcattcc taagagggga tatttagaca tcattctttc tgttcatggt
    10081 ttatatttgc aaatgtaagg aaataaagtc gatttccgta tagcaaggat gtaaaagtta
    10141 gcaaaaaagg tcgttccaaa gcatggaacg accttttgca gttatcgttt ttacgactaa
    10201 tcttagaaga acaggtaacg tgtatccttc acttttcctt tcagatacag atcgttcatc
    10261 agacggcttg cgaagcgtgc gtgcatatta gccaatgtag cttcttcatc tttagcgtta
    10321 aaagtatcgc tcagtttgtc tttgccatac atctgaagca caaatacacc ggcattacct
    10381 ttgattggag cactcagttt gttcatttca gccacagaag cataagcacc taccagcggt
    10441 tcgctgctgc gcaattcaga gacataagcg ggagcggcaa atgtaaccag cttcaaagaa
    10501 tcgctgactg cgccgggcat agccttgtac tggtcgagag aagttgcatt ggcagctttc
    10561 atatcagcca tgatcttttc ggctttctta tctttaacga tttcagctct caactgatcc
    10621 tgtacagctt tcagcggacg atatccttcc ggagtaacac caaccagagc tactgcaacc
    10681 atatggtcgc tttcgccaca ttcatacaaa ccggaaacat cacccggttt agcggcaaat
    10741 gcccatctca atgcttcttt agtacctctt acaccaccga tagtgtgttc tgagctatac
    10801 aagtctcttc tgtcaagcag tttgtatccg gcttcttcag cgttagcgat catcttttca
    10861 gcagtaggat tggcagcgat gaactggctg aagtcattgt aagcacggtt ataagtttct
    10921 ttactgaatt caacttcacg tttcacaaca gctactttat atttatcctt cacagctttc
    10981 ttgttagtca cctgcaggat tacattagct tgtcccaacg gcaggtttac tacttcgttc
    11041 acgcctgtat tattgatagc agagataaac ttcaggttgt caccatcgat ctgtgcgcct
    11101 tcatactgtg cagagctcat ccagttagtc tcacccgtct gaccgtattt cttagccaga
    11161 tctgcgaagt tagcaccgcc tttgatagca gtatagatac tgtccgccaa ggcttttgtc
    11221 ttcaaagcgt cttctgcaaa cacctgaatc tgacggaact cgattgagtc ggcagcagct
    11281 gtttttgcaa ccactttgaa tgaattaata gtattgtcgg caccattata gtacggacca
    11341 taaacagaac caacggatgc agagtccaga cgggcaacta catctgacgg gaaagctgtt
    11401 ttattataga acaagtctac ataaggagct tccgaaccta cagaacggat gaaagaagta
    11461 taatcatctg ttgtagtagc cagctgtgca gtagcttcgt ctacttcctg ctggatagca
    11521 gctctgtctt ccgcacttgc agtcacctga acatcaatgt acttgatatc acggctttcc
    11581 tgatattgct tgaactgttc tttcttcttg ttataaaggt ctttcagttc cgattctttc
    11641 actacgattg tagagtctac tacagaagaa taaggaacgg cagccatcaa caagtcatat
    11701 tgattcactc ttgcgtcgaa agcgtcctgt gcttctaccg ggttagagag aagcgctttt
    11761 gctaccaatg cctgatattt ttctgccagg cggctctgaa ccaatgtctt ctggatgaat
    11821 gaccagtatt tgtacatgtt gttgtactgt tctgcatact gagccggcat ctgagattcg
    11881 ttcattttag cgtaatctac cagaaactta ttcagcatat ccttatcgaa agcaccggtc
    11941 tgcgggttgc ggaaaggagt ctgttgcaac aacggatgca cgcctgcttt caggatatcc
    12001 tgaatttcag cagcagagac tgtcagtccc aatgcttttg cttctttctc aaccagtttg
    12061 ttattaacgt aggaacgcca tacttcgtcg
//
