LOCUS       c00015_gnlPro..        16569 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ECBEEEHA_15.
ACCESSION   c00015_gnlPro..
VERSION     c00015_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 17:14:22
            Original ID  :: gnl|Prokka|ECBEEEHA_15
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16569
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16569
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3011:6569](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3012..6569
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16569
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16569
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(439..1593)
                     /locus_tag="ctg15_1"
                     /transl_table=11
                     /translation="MALASGETNYMAPASARQMASDLALLPMWYAEAGSAVLAPSAYNA
                     DFLKTKSELLGMDVALLTEPEVADGKDWKFSPWGWDPALRKRLMTLGAGQTELPSADYM
                     NILREHSHRLQAVKLLPGLRLNEYFCGESFYLSTLAECSAFVEGREACLLKAPLSGSGK
                     GLNWCKGIFTTFISGWCARVAASQGGVVGEPIYNKVEDFAMEFYADGRGRVVFAGYSVF
                     HTGGSGMYAGNDLLSDEKILQKLSAYVPQEEFIRLRTRLEEELSALFGGFYHGYLGVDM
                     MICHFPDEAPVYRIHPCVEINLRMNMGVVAWLLTDRYLAADAEGVFRIDYYPLAGQALE
                     EHRQMSASFPLSVENNRVCAGYLPLVPVTPQSRYRAFLLLTLPQ"
     CDS             1800..2978
                     /locus_tag="ctg15_2"
                     /transl_table=11
                     /translation="MESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGIKGTRGVGKT
                     TFLLQYAKEKFGTDRSCLFINMNNFYFSGHSLVDFANEFQKRGGKVLLIDQVFKHPEWS
                     KELRMCYDRFPSLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREFLNLQTGMKFR
                     AYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENLLKTMNMMVE
                     VDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDVQTSRATVMNYIKYLADAR
                     LINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFVNTLWKDHKVHKGD
                     KNVSFMVDEVMPFKICAEGTKIKNNPDVTYALQKAEIGRGNQIPLWMFGFLY"
     CDS             3012..6569
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_3"
                     /sec_met_domain="PFOR_II (E-value: 3.3e-18, bitscore: 58.2,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 5.3e-82, bitscore: 267.2,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 5.2e-31, bitscore: 100.3,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 9.5e-12, bitscore:
                     37.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 1.7e-11, bitscore: 37.2,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 3e-07, bitscore: 22.4,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.00017, bitscore: 14.4,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 7.9e-25, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENEDLAPLIDQEALAEFRARALNPMNPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKSIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQIISVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIAMEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLTVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNAENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKAFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKSKQHLVDIKANVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTMNEKGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARLVKVMNEAIASDCCPAEYKEVFAEWINNMLDAEKTKE
                     LAEKIIPMVEAAKDKCNHCKQIADLQQYLVKRSQWIIGGDGASYDIGYGGLDHVIASGK
                     DVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQIA
                     MGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLWR
                     YNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPAEAEELFKAAEENAKW
                     RYNSYKRLARENWGADTAE"
     CDS             6694..6882
                     /locus_tag="ctg15_4"
                     /transl_table=11
                     /translation="MIGFVIWIIGLILTFRAAIEIWNINAAVEKRLIAIVLIVLTSWLG
                     LLFYYFYGKERMAGWLK"
     CDS             complement(6893..7753)
                     /locus_tag="ctg15_5"
                     /transl_table=11
                     /translation="MNKIKMIAAMFIAGILLTFVSCGDNGKSKKISIAYANWSEGIAMT
                     NLAKAIFEDQGYDVKLLNADLAPIFTSISRKKADVFMDVWMPVTMEDYMKQYGDKLEVI
                     GDIYDGARIGLVVPDYVTINSIEELNAEKERFSGQIVGIDAGAGIMKATDQAIKDYGLD
                     YKLMTSSGPAMTASLKKAIDKKDWIVVTGWTPHWMFDRFKLKVLQDPKLIYGNTESIHT
                     IAWKGFSEKDPFAAELLGNIRLTDAEISSLMTALEEAQTTERQAARQWMEEHQELVNSW
                     IPEKD"
     CDS             complement(7781..8611)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 91.7; E-value: 1.6e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg15_6"
                     /sec_met_domain="BPD_transp_1 (E-value: 1.9e-28, bitscore:
                     91.7, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIETAINWLTEHFASFFDALSMGIGGFIDGFQHVLFGIP
                     FYITIAVLAALAWFKSGKGTAVFTLLGLLLIYGMGFWEETMQTLALVLSSTCLALLLGV
                     PLGIWTANSDRCNKIMRPVLDFMQTMPAFVYLIPAVLFFGLGTVPGAFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATPWQLLYKVQLPLALPTILTGINQTIMMSLSMVVIA
                     AMISAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIVLDRITQGMADNRKSKKK"
     CDS             complement(8608..9834)
                     /locus_tag="ctg15_7"
                     /transl_table=11
                     /translation="MSKIEIKDLYLVFGNEKQKALKMLKEGKTKSEILKATGCTVAVKD
                     ANLSINEGEIFVIMGLSGSGKSTLLRCINRLIRPTSGEVIINGTDIAKVSDKELLQIRR
                     KELAMVFQNFGLLPHRSVLHNIAFGLELQGVKKGEREQKAMESMQLVGLKGYENQMVSE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLTLQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEIVQIGTSEEILTEPANAYVERFVENVDRSKIITASSVMVD
                     KPIVARLKKEGPEVLIRKMRERNLTVLPVVDSNNLLVGEVRLNDLLKLRKEQIRSIESV
                     VRHEVHSVLGDTVLEDILPLMTKTNSPIWVVNENREFEGVVPLSSLIIEVTGKDKEEIN
                     EIIQNAIEL"
     CDS             10307..11590
                     /locus_tag="ctg15_8"
                     /transl_table=11
                     /translation="MFNRAITIFLGKDNCHYTTKEKQTGTATDDKSQVQFLSKKNPKMP
                     FFYSRRNLYMIGFLLAFIVTLLEFIRGRHQNFMVFSDATQFFWQGISPYTTEFVEAHGR
                     YFLYSPVFTVLFAPFAYLPAWLGPFAWNLFNYSLFFMAIFTLPQQFTQQQKCRMFLFLL
                     LILGQSLLSFQYNITVAYLFLFAYTLLEKDRGFLAVLLIMISGCTKVYGIFELALLLCY
                     PHVWRNFGYAVTMGIVLLALPLIKIAPADLLPYYEEWCHSLAVHQSAGAYDSFFYARPI
                     AAWTLPHFRALQIGMLGLLTLLFLGNFRKWSSFAFRAQALGILMGWVVLLSDSAEKHTY
                     IIALAGFMLWYWSRPTRTTTDKILFWCCFVLLCIVPIDIFVPVPIRDFITRTLWLHVWV
                     FFIVWIRMIWLTFLASFIHPRATNVLSD"
     CDS             complement(11553..11885)
                     /locus_tag="ctg15_9"
                     /transl_table=11
                     /translation="MKDYKVDKESFSESFRKEVYEVVSQIPVGKVSTYGGIALLLGAPQ
                     CSRMVGRALKEVPDELSIPCHRVVNSTGRLVPGWVEQKQLLLAEEVSFKANGCVNLKEH
                     LWHVDE"
     CDS             complement(11913..14666)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 63.7; E-value: 6.2e-20)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg15_10"
                     /sec_met_domain="Peripla_BP_1 (E-value: 7.3e-20, bitscore:
                     63.7, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTMRYLKWMLVLFGLIGMTACRQDTPRFRIGVAQCSDDSWRHKM
                     NDEILREAMFYNGVSVEIRSAGDDNSKQAEDVHYFMDEGVDLLIISANEAAPMTPIVEE
                     AYQKGIPVILVDRKILSDKYTAYIGADNYEIGRSVGNYIASSLKGKGNIVELTGLSGST
                     PAMERHQGFMAAISKFPDIKLIDKADAAWERGPAEIEMDSMLRKHPKIDAVYAHNDRIA
                     PGAYQAAKMAGREKEMIFVGIDALPGKGNGLELVLDSVLDATFIYPTNGDKVLQLAMDI
                     LEKKPYPKETVMNTAVVDRTNAHVMQLQTTHISELDKKIETLNGRIGGYLSQVATQQVV
                     LYGSLIILLLVAGLLLVVYKSLRSKNRLNKELFKQKQQLEEQRDKLEEQRDQLIQLSHQ
                     LEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADKTLSGDQHRMLMLIQRNVNILLR
                     LVNQILDFRKYENGKMEYTPVTVDVLSSFEGWNESFQAAARKKHIHFSFDSMPDTDYHT
                     LADMEKLERIYFNLLSNAFKFTPENGKIAVRLSSLSKEDKRWIRFTVANTGSMISAEHI
                     RNVFDRFYKIDMHHTGSGIGLALVKAFVEMHGGMISVESDEKQGTVFTVELPVQSCEAV
                     AAEPDTTLVSADSRTTDVLLAEEEELEKGYDSSKPSVLIIDDNEDIRSYVHTLLHTDYT
                     VIEAADGSEGIRKAMKYVPDLIISDVMMPGIDGIECCRRLKSELQTCHIPVILLTACSL
                     DEQRIQGYDGGADSYISKPFSSQLLLARVRNLIDSHRRLKQFFGDGQTLAKEDVCDMDK
                     DFVERFKSLIEEKMGDSGLNVEDLGKDMGLSRVQLYRKIKSLTNYSPNELLRIARLKKA
                     ASLLASSDMTVAEIGYEVGFSSPSYFTKCYKEQFGESPTDFLKRKG"
     CDS             complement(14999..16225)
                     /locus_tag="ctg15_11"
                     /transl_table=11
                     /translation="MFFFLIVPLFLALFYKPIAYLCGRFLNNKSKRENYFMKHISNFLR
                     SKNWNVFLFLYLALPLFAQKEYKIDQVSVVNVGDGRLLFQELKTEKALNGEHRIIDGYH
                     SAYVLASFKDGFYDGGYKEYVDNILITEGSYKEGRKDGLFKINSKFDGKLKEEKSYKEG
                     KLDGTSKSYFTTGKVESERNFRMGKEHGKQLSYESDGTLRKEHNYKDGKQVGKQYTFLK
                     GTYDLYETVYFNEEGLQDGEYSSVFTFGSPRILGSYKNGKKNGRWTTFAESGDTLMIET
                     YLDGKEDGLHVSFANGSGVRQKEYYMKNDRKDGLYREYNLENGELRYEATYQAGRLHGK
                     ERRLIVSNRFDYWETSTYVNGRQNGPFEARYVKNDQLRECGEYKNGRRVGRWKRYTIDG
                     KLEKEWDEN"
ORIGIN
        1 tatttcatct ttattttcga tttttgaagt gtcaacttat tcagtacact acaaaactat
       61 ctgaaactac tgttgatttg attgacttaa ccgcatgttc caatcacatt gaacgcatca
      121 gctacttcaa tagtactgct ctctctgaaa acattaaatc atatatcagt caataataca
      181 taaattatca gtccttaata cttgatttct caattattaa tatctgagaa atcaaacgtt
      241 aacagttgag atatcagata ttaacatcct gtaaatcaaa gaataacaca gtaaaaacgg
      301 tatttatcag gacgatgcag agtgagagca agtccttgct ctcactctgc taccactgga
      361 tctctaacag ctaaaacatc gatgaataaa gggatacaga cgaactgtta gagcatgaga
      421 gcaaaagcac tatctttttc actgggggag agtaagcaaa agaaacgcac gataccggct
      481 ttgaggcgtc accggtacta acggcaaata tccggcacac acccgattat tctctacgga
      541 caaagggaac gaagccgaca tctgccgatg ttcctccaaa gcctgaccgg ctaaaggata
      601 ataatcaatc cgaaaaactc cttccgcatc cgcagccaaa taacgatccg tcaagagcca
      661 tgccaccacc cccatattca ttcgcagatt aatttcgaca caaggatgaa tccggtaaac
      721 aggcgcttca tccggaaaat gacaaatcat catatccact cccaagtatc catgataaaa
      781 gccaccgaac aaagctgaca attcttcttc caaacgagtc cgcagcctga taaattcttc
      841 ttgtggcaca taagccgata gtttctgcag aatcttctcg tcagacagca agtcattccc
      901 tgcatacatc ccactcccac ccgtgtggaa gaccgaatat ccggcaaaaa caacccttcc
      961 tctcccgtca gcataaaact ccatagcgaa atcttccacc ttattatata taggttcgcc
     1021 taccacccca ccctgagaag cagcgacacg ggcacaccaa ccggaaataa aagtagtaaa
     1081 tatgccttta caccaattca atcctttccc gcttccggaa agcggagctt ttaacaagca
     1141 cgcttcccgc ccttcgacga acgcactgca ctccgccaaa gtactcaaat aaaaagattc
     1201 tccacagaag tattcattca accgcaaccc aggcaacaac tttaccgcct gcagacgatg
     1261 cgaatgctct ctcagaatat tcatataatc cgcagaaggc agctccgtct gacctgcccc
     1321 caatgtcatc aaacgcttcc gcaaagcagg gtcccaaccc cacggagaga acttccagtc
     1381 tttaccgtca gccacttccg gttccgtcaa caaggccaca tccatgccca aaagttcact
     1441 ctttgttttc aggaagtccg cattataagc agacggtgca agcaccgcac ttcccgcttc
     1501 ggcataccac ataggaagca acgccaggtc actcgccatc tgtcgggcgg aagccggcgc
     1561 catatagttc gtctcaccgc ttgccaacgc catatcatgc tccggattga atatataaac
     1621 aggtcttttc gtcatgtcaa agatggattc aacacattat tctgcaaata tatacaggaa
     1681 ataatcagga acttacacaa taaagagaaa cttataaatt aaagcacatt tttgctatct
     1741 ctactttgca aatcctaaaa aaagcactat atttgccagc cgaaaaacaa agaaacgaaa
     1801 tggaatcatt ctatcgcaca cacgcctacc tcgttgagca caccaatgcc cccgttcgcc
     1861 gcgatcttat ggacgagatc gactggagtg accgtctgat tggtatcaaa gggacacgtg
     1921 gcgtaggaaa aaccactttc ctcctgcagt acgccaaaga gaaattcggc accgaccgtt
     1981 cctgtctgtt catcaatatg aacaactttt atttctccgg tcacagcctt gttgacttcg
     2041 ccaacgagtt tcagaaacgt ggcggaaaag tactgctgat cgaccaggtg ttcaaacatc
     2101 ccgaatggag caaagagcta cgaatgtgct atgaccgttt ccccagcctg aagattgtct
     2161 tcaccggttc ttccgtcatg cgactcaaag aggaaaacct cgaattgcgt gacattgcga
     2221 aaagttataa cctgcgcgga ttctctttcc gtgaatttct gaacctgcag acaggaatga
     2281 aattccgggc atacagcctc gaagaaatcc tcagtacaca tgaacagata gccaaaggag
     2341 tactttccaa agtacgaccg ctggattatt ttcaggatta cctgcatcat ggtttctacc
     2401 ctttcttcct tgaaaaacgt aatttctcgg agaatctgct gaaaacaatg aacatgatgg
     2461 tagaagtgga tatcttgctg atcaaacaaa ttgagctgaa atatctttca aagataaaaa
     2521 aattactata tttgttggct gtggacggac cgaaagctcc gaacgtgagc caactggcaa
     2581 gtgacgtaca gacatcccgc gctacggtaa tgaactatat caagtatctg gcagacgcgc
     2641 gtctgattaa tctggtttac ccgaaaggag aagaattccc aaagaaaccg tcaaagatta
     2701 tgatgcacaa ctctaacctg atgtactcca tttatccggt gaaagtggaa gaacaggatg
     2761 tactcgacac gttcttcgtt aacactttat ggaaagacca taaggtacat aaaggagata
     2821 aaaacgtctc tttcatggta gacgaagtga tgccgttcaa aatttgtgcg gaaggtacaa
     2881 aaataaagaa taacccggac gtgacgtatg cgttgcaaaa ggctgagata ggccgcggca
     2941 accaaatacc tctttggatg ttcggattct tatactaaaa agatttattt acttaaatat
     3001 ttaatttagt tatgactaaa cagaagaaat tcatcacatg tgatggtaac caagctgcag
     3061 cacatatctc gtatatgttc tctgaagtag cagctatcta ccccatcact ccttcttcga
     3121 ctatggctga gtacgtagac gaatgggctg ccgcaggacg taagaacatc ttcggcgaaa
     3181 cagtattggt acaggaaatg caatctgaag gtggtgctgc cggtgcagtt cacggttctc
     3241 ttcaggctgg tgcattgact actacttaca ctgcttctca gggtcttctt ttgatgatcc
     3301 ctaacatgta caagattgcc ggtgaattct tgccttgtgt attccacgtt tctgctcgta
     3361 cactggcttc tcacgcattg tgtatcttcg gtgaccatca ggacgtaatg tcagctcgtc
     3421 aaaccggctt cgctatgttg gcagaaggtt ctgtacagga agttatggat ttggcaggtg
     3481 ttgctcatct ggctactatc aaatcacgcg ttccgttcat gaacttcttc gatggtttcc
     3541 gtacttctca cgaaatccag aagatcgaaa tgttggaaaa cgaagatctt gctccgctga
     3601 ttgatcagga agctttggct gaattccgtg cccgcgcact gaatccgatg aatccggtag
     3661 cccgtggtat ggctgaaaac cccgaccact tcttccaaca tcgtgaatca tgcaataact
     3721 actatgaagc agttcctgct atcgtagaag aatacatgaa cgaaatttcc aagatcacag
     3781 gccgcaaata cggtttgttc gattactacg gtgcagaaga tgcagaacgc gtaattatcg
     3841 caatgggttc tgtaactgaa gctgcccgcg aagctatcga ccacttggta gcaaacggcg
     3901 aaaaagtagg tatggttgcc gtacacttgt atcgtccgtt ctctgctaaa cacttcctgg
     3961 ctgctgtacc caagactgca aagagcatcg cagtgcttga ccgtacaaaa gaaccgggtg
     4021 ctaacggcga acctctttac cttgacgtta aagactgctt ctatggcgca gaaaatgctc
     4081 ctgttatcgt tggcggtcgc tacggtctgg gttcaaaaga taccactccg gcacagatca
     4141 tctctgtatt cgaaaacttg gctatgccaa tgccgaagaa ccacttcact atcggtatcg
     4201 tagacgacgt tacgttcact tctcttcctc agaaagaaga aatcgctctg ggcggtgaag
     4261 gtatgttcga agctaaattc tacggtctgg gtgctgacgg tactgtaggt gccaacaaga
     4321 actctgttaa gattatcggt gacaacaccg acaaacactg tcaggcttac ttctcttacg
     4381 actccaagaa gtcgggtggt ttcacttgtt ctcacttgcg tttcggtgat actccgatcc
     4441 gttctactta cttggtaaat actccgaact tcgttgcttg tcacgttcag gcttacctgc
     4501 acatgtacga cgtaacacgt ggtttgcgta agaacggttc tttcttgctg aataccatct
     4561 gggaaggcga agaactggct aagaacctgc ctaacaaggt gaagaaatac tttgcacaga
     4621 acaacatctc tgtatactat atcaacgcaa ctcagattgc aatggaaatt ggtttgggca
     4681 accgtaccaa tacaatcctt cagtctgcat tcttccgtat cacaggcgta atccctgtag
     4741 atcaagctgt tgaacagatg aagaaattca tcgttaagtc ttacggcaag aagggtgaag
     4801 acgttgttaa caagaactac gctgctgtag accgcggtgg tgaatacaag actctgactg
     4861 tcgatcctgc ttgggctaac ctgccggatg atgcaaaagc agaaaacaat gatcctgctt
     4921 tcatcaacga agtagttcgt ccgatcaatg cacaggacgg tgacttgctg ccggtatctg
     4981 cattcaaggg tatcgaagac ggtacttggt atcaaggtac ttccaaatac gaaaaacgtg
     5041 gtgtagctgc attcgttccc gaatggaatg ctgaaaactg tattcagtgt aacaagtgtg
     5101 cttacgtttg tcctcacgct tctatccgtc cgttcgtact cgatgctgaa gagcagaagg
     5161 gtgctaagtt cgagcaactg aaagctgtag gtaaagcatt cgatggtatg acattccgta
     5221 ttcaggtaga cgttctcgat tgtctgggtt gcggtaactg tgccgacatc tgtccgggta
     5281 atccgaagaa gggtggcaag gcattgacca tgaaacacct tgaaagccag ttggccgaag
     5341 ctgataactg gacttactgc gctgaaaacg tgaagagcaa acaacacctg gtagacatca
     5401 aggctaacgt gaagaactct cagttcgcaa ctccgttgtt tgagttctca ggcgcttgct
     5461 ccggttgtgg tgaaactccg tacgtgaaac tgatttctca gttgttcggt gaccgtgaaa
     5521 tggttgctaa cgctacagga tgttcttcta tctactccgg ttcagttcct tctactccgt
     5581 acactatgaa cgaaaagggt cacggtcctg catgggctaa ctccttgttc gaagacttct
     5641 gtgaatttgg tctgggtatg gaactggcta acgaaaagat gcgtgcccgt ctggtgaaag
     5701 taatgaacga agctatcgct tctgattgct gcccggctga atacaaagaa gtatttgctg
     5761 aatggatcaa caatatgctg gatgcagaaa agactaagga actggccgaa aagatcattc
     5821 cgatggtaga agctgctaaa gataaatgca accactgcaa gcaaatcgct gatctgcaac
     5881 aatatcttgt taaacgcagc caatggatca tcggtggtga cggtgcttct tatgatatcg
     5941 gttacggtgg tcttgaccat gtaatcgctt ccggtaagga cgttaacatc cttgtattgg
     6001 atactgaggt ttactctaac acaggtggtc agtcttctaa agctactccg gtaggcgcta
     6061 tcgctaagtt tgctgctgca ggtaagcgtg tacgtaagaa agacctcggt ctgatggcta
     6121 ctacttacgg ttatgtatat gttgctcaga ttgctatggg tgctgaccag gctcagactc
     6181 tgaaagctat ccgtgaagct gaagcatatc cgggaccatc actgatcatc gcttacgctc
     6241 catgtatcaa ccacggtctg aaagccggta tgggtaagag ccaggaagaa gaagaaaagg
     6301 ctgttaagtg cggttactgg cacttgtggc gttacaaccc tgctttggaa gaagaaggca
     6361 agaatccgtt ccaactggat agcaaagaac ctaactggga agacttccaa ggtttcttga
     6421 agggtgaagt tcgttacgct tctgtaatga aacaatatcc tgctgaagct gaagaactgt
     6481 ttaaagctgc tgaagaaaac gctaaatggc gttacaacag ctacaaacgt cttgccagag
     6541 aaaactgggg agctgataca gctgaataat aagtagaaat actttgtaca taataaaagg
     6601 caggaatcct ggaaacagat tcctgccttt tttgtttata tcttagaagt aacgattact
     6661 tctcacgaag atattcatta aaactctaaa gatatgatcg gatttgttat ttggattatc
     6721 ggtttgatac tgactttcag agctgccata gagatttgga atataaatgc ggctgtagag
     6781 aaaagactta tagcgattgt attaatcgtt cttaccagct ggctgggact acttttctac
     6841 tacttctatg gtaaagaaag aatggcggga tggttgaagt agtgtttgca tatcaatctt
     6901 tctcaggaat ccaactgttc accagttcct gatgttcttc catccattga cgggcagcct
     6961 gtctttccgt tgtctgcgcc tcttccagag cagtcattaa ggagctgatt tccgcatctg
     7021 tcagacgaat gttgcccaaa agttcggcag caaaagggtc tttctcgcta aaacctttcc
     7081 atgctatggt atgaatggat tccgtatttc catatatcag cttcgggtcc tgaagaactt
     7141 tcagcttgaa acggtcgaac atccagtgag gcgtccatcc cgtcacgaca atccagtctt
     7201 tcttatcaat cgctttcttt agggaagcag tcatggcagg tccgctcgaa gtcatcagtt
     7261 tataatccaa tccatagtct ttgatggcct gatcggtagc tttcataata ccggctccgg
     7321 catcaatacc gacaatctga ccggagaaac gttccttttc cgcgttcagt tcttcgattg
     7381 agttgatcgt aacgtaatcc ggaaccacca gcccgatacg ggcaccatca taaatatccc
     7441 cgataacttc gagtttatcc ccgtattgtt tcatataatc ttccatagtg acaggcatcc
     7501 agacatccat aaatacgtct gctttcttac gggagataga ggtaaatata ggtgcaaggt
     7561 cggcattcag caactttaca tcgtacccct gatcttcaaa aatcgctttg gcaaggtttg
     7621 tcattgcaat accttccgac cagttggcat aagcgatact tatcttctta ctctttccgt
     7681 tgtctccgca ggaaacgaag gttaagagta tgccggcaat aaacattgcc gcaatcattt
     7741 ttatcttatt cattgattat tcctttcttt ggtgtgattc ttatttcttt ttactttttc
     7801 tgttatctgc cataccctga gtgatgcggt ccagcacgat cgccaatatc acgactgcga
     7861 taccgccttc aaatccgagt ccgattttca tttgggtgat acctttcagc acgatttctc
     7921 ccaatcctcc cgcagaaatc atggcggcaa tcactaccat cgaaagtgac atcatgatcg
     7981 tctgattgat tcccgtcaga attgtaggca atgccaaagg caattgcacc ttataaagaa
     8041 gctgccaagg agtagctcca aaagaacggg aggcttctac tacgttttta ggaacctgac
     8101 gaatgcccag accggtcaga cgaaccacag gaggcattgc aaagatgatg gtggcaaaag
     8161 ctcccggcac agttcccaat ccgaagaata ggacagcagg aatcagatag acaaaggcag
     8221 gcattgtctg cataaagtcg aggacagggc gcattatctt gttacaacga tcactgttgg
     8281 cagtccagat tcccaacgga acgcctaaaa gcaatgccag acaagtggaa gaaagtacca
     8341 atgccaatgt ctgcatcgtt tcttcccaaa agcccatgcc gtaaataagc aataaaccca
     8401 agagggtaaa tacggctgtc cccttacccg acttaaacca ggcgagcgca gccagcactg
     8461 caattgtgat ataaaaaggt attccaaaca gtacgtgctg aaaaccgtct atgaatcctc
     8521 cgatccccat gctgagagca tcaaaaaagg aagcaaaatg ttctgtgagc caattaatgg
     8581 cagtctctat atattgtccg atatttatca taattctatt gcgttttgaa tgatttcatt
     8641 aatttcttct ttatcttttc ccgttacttc gatgatcaat gaggaaagtg gcactacgcc
     8701 ttcaaactcc cgattctcat ttacgaccca gattggcgag ttcgtttttg tcatcaacgg
     8761 aagaatatct tccagcaccg tatcacccag cactgaatga acttcatgcc ttactacgga
     8821 ctcgatggag cggatttgct cttttcgtag tttcagcaag tcattcaacc gcacctctcc
     8881 tactaacaga ttattggaat cgactaccgg aagaacggtc agattccgtt cgcgcatctt
     8941 acggatcagc acctccgggc cttctttctt caaacgtgcc actatgggtt tatctaccat
     9001 aacagaggaa gctgttataa tcttgcttcg atctacattc tccacaaatc gttctacata
     9061 agcgttggca ggttcggtca ggatttcttc cgatgtaccg atttgtacaa tttctccatc
     9121 cttcatgata gcaatccggt cacccaattt aatcgcttca ctcaggtcgt gagtaataaa
     9181 gacaatcgtt tttttcatct tcgactgcaa agtcagcagt tcatcctgca tctgcacacg
     9241 gatcaaagga tcgagtgccg agaaggcctc atccatcaac aggacttcgg gattattggc
     9301 caaagcccgc gccagcccga cacgctgctg catcccaccc gacagttcac ttaccatctg
     9361 attctcgtag cctttcagcc ccaccagttg catgctttcc atcgctttct gctcccgttc
     9421 tccctttttt actccctgta gttcgagccc gaaagctata ttatgcaaga cagaacggtg
     9481 aggaagcaga ccgaagttct gaaagaccat agccagttct ttccggcgaa tctgcaacag
     9541 ttccttatcc gacactttgg ctatgtctgt tccattgata atcacttctc cggaagtagg
     9601 gcgtatcaaa cggttgatgc agcggagtaa agtggacttt ccactaccgg acagccccat
     9661 aatgacgaat atttcgcctt cattaatgga aagattcgca tctttcaccg caactgtaca
     9721 tccggtcgct ttcaatattt cactttttgt tttaccttct ttcaacatct tcaaagcctt
     9781 ctgcttctca ttgccaaaaa ccagatagag atctttaatt tctattttac tcatacaata
     9841 aaatggttta ggttattaaa ataatataca cagcaagaca agaacaaacg ataacaggaa
     9901 tctttcttta tatcgtataa agttctgatt taaatacggg acaaataaca atgaatcccg
     9961 aaataattaa taaaatgatt attgacagac tgagtaatta aaaaaggaat agaatttgat
    10021 aagataatcc tttcaacgaa tagcaaaaaa tagcattttt atgtataaaa acagcctgtt
    10081 ccagtatctt gctggcacaa agatacaaaa aacggattaa acatacaaat tatattcaaa
    10141 atccggggca tacagagggc tttatttgta atgatatgga aagtttccgg gtaatattcc
    10201 cctatcactc agcaaaatag aacaaaccgg cagataaata taaaataagt ttgaatattt
    10261 cacttaaaca ccgtatattt ggcgtcaata actaaactag atttatatgt tcaacagggc
    10321 tattacaatt ttcctgggga aggataattg tcattacaca acaaaagaaa aacaaacagg
    10381 tactgccaca gacgacaaaa gccaagtaca gttccttagt aaaaagaacc ccaaaatgcc
    10441 gtttttctat agccggcgga atctctacat gataggtttc ctgctcgctt ttatagtgac
    10501 tctgctcgaa tttatacgag gacggcatca aaactttatg gtcttctcgg acgctactca
    10561 attcttctgg caaggcatca gcccatacac aactgaattt gtagaagctc acggacgcta
    10621 cttcctttat tctccagttt tcacggtatt gttcgctccg tttgcgtatc tgcctgcatg
    10681 gctgggacct ttcgcgtgga atctattcaa ttattcgctg ttctttatgg cgatcttcac
    10741 gctgccccaa caattcaccc agcagcagaa atgccgtatg ttcctttttc tgttactgat
    10801 tttaggacaa agtttacttt catttcagta taacataacg gtagcctatt tattcttatt
    10861 cgcctatacg ttattggaaa aagaccgtgg atttctggct gttctgttaa tcatgatttc
    10921 gggatgtacc aaagtatatg gaattttcga actggcattg ttgctgtgct atcctcacgt
    10981 atggcgtaac tttggctatg ccgttacaat gggcattgta ttgcttgcat taccgttaat
    11041 caaaatagct cctgcagatt tgctccccta ttatgaagaa tggtgccata gtcttgctgt
    11101 tcatcagtcc gccggagctt atgattcatt tttctatgcc cgccccattg cagcatggac
    11161 attaccacac ttccgtgcac ttcagatagg aatgctcggc ttgctgactc tgctcttttt
    11221 ggggaatttc cgcaaatggt cgtcttttgc cttccgtgcc caggctttgg gcattctcat
    11281 gggctgggta gtattactga gtgactccgc cgaaaaacat acctatatta tcgcattggc
    11341 aggtttcatg ctctggtatt ggagcaggcc aacacgtacc acaacagaca agattctatt
    11401 ttggtgctgt tttgtgctgt tatgtatcgt tcctatcgac atattcgtcc ctgtacccat
    11461 cagagatttc attaccagga ccttatggct tcatgtatgg gttttcttta ttgtatggat
    11521 acggatgata tggcttacct tccttgcatc cttcattcat ccacgtgcca caaatgttct
    11581 ttcagattaa cgcatccgtt agctttgaaa gaaacttctt ctgccagcaa gagttgtttt
    11641 tgttccaccc aaccgggcac cagccttccg gtggaattta caactctatg gcagggaatg
    11701 gataattcat ccggcacttc tttcaatgca cgccccacca tccgcgagca ttggggtgcc
    11761 cccaagagca aagcaatacc tccataggta gatacttttc ccacaggtat ctgggatacg
    11821 acttcgtaca cttccttccg aaaggattcg gaaaaactct ctttatctac tttataatct
    11881 ttcatatatc cctctttacg atatcaatga aatcatcctt tccttttcag gaagtctgtc
    11941 gggctctctc cgaactgctc tttatagcac ttggtgaaat aagaaggtga actgaaaccg
    12001 acttcataac caatctccgc tacggtcatg tccgaagaag caagcaaaga agctgccttc
    12061 ttcaaacggg cgatacggag caattcattc ggagagtagt tagtcaatga tttaatcttg
    12121 cggtaaagct gcacacggct tagtcccatg tctttgccca agtcctccac attcaaaccg
    12181 gagtctccca ttttctcttc aatcaatgac ttgaatcttt ctacaaaatc cttgtccata
    12241 tcgcagacat cttcttttgc caatgtctgc ccgtcaccaa agaactgttt cagacgacgg
    12301 tgagaatcaa tcagattgcg gacacgtgcc agcaacagct gtgaactgaa cggctttgaa
    12361 atataagaat ccgcaccacc gtcatatccc tgaatacgct gttcgtccag tgaacacgct
    12421 gtcagcagaa taaccggaat atgacaggtc tgtaactcac ttttcagccg gcggcaacat
    12481 tcaatgccat caatgcccgg catcatcaca tcagaaatga tcaggtccgg aacatacttc
    12541 atagccttac ggattccttc ggagccgtct gccgcttcaa tcaccgtata gtctgtatgc
    12601 aacagcgtat ggacatacga acggatatcc tcattatcat caataatcag tacggacggt
    12661 ttggaagagt catatccttt ttccagttct tcctcttccg ccaatagaac atctgttgta
    12721 cgggaatccg cagaaacaag ggtggtatcc ggttcggcag caacagcctc acaagactgt
    12781 acaggcagtt caacggtaaa gaccgtgccc tgtttctcat cgctctctac ggagatcata
    12841 ccaccgtgca tttctacgaa ggcttttacc aatgccagtc cgattcccga accggtatgg
    12901 tgcatatcga tcttatagaa acggtcgaat acattgcgaa tatgttcggc agaaatcata
    12961 gaaccggtat ttgccaccgt gaaacgtatc catcgcttgt cctctttact aagggaagac
    13021 agacggacgg ctattttccc gttttccggt gtaaacttaa aggcattgga cagaagattg
    13081 aaataaatac gttccagctt ctccatgtct gccagtgtat gataatccgt atccggcata
    13141 ctatcaaaag aaaaatggat atgcttctta cgggctgccg cctgaaaaga ctcattccat
    13201 ccttcgaaag aagaaaggac atccaccgta accggagtat attccatctt gccgttttca
    13261 tatttacgga aatccagaat ctgattgacc aggcgcaaaa ggatattcac atttcgctga
    13321 atcagcatga gcatccggtg ctgatctcca ctcaatgtct tgtccgccaa taaatgttct
    13381 accgggtcgg caaccaatgt caacggagta cggaagtcgt gagaaatatt ggtgaagaat
    13441 accagcttgg catgagtagc ttcttccagt tgatgagaaa gttgtatcaa ttggtcacgc
    13501 tgttcttcca gtttgtcacg ctgctcttcc aattgctgct tctgcttaaa aagctcttta
    13561 ttcaagcgat tcttagagcg gagtgattta taaacgacca ataataaacc ggctaccaat
    13621 aaaaggataa tcagactgcc gtataaaacg acctgttgtg tagctacctg agagagatag
    13681 ccaccgatac gtccgttgag cgtttcaatc tttttgtcga gttcggaaat gtgtgtggtc
    13741 tgcaactgca tgacgtgtgc gttggtacgg tccacaacag cggtattcat caccgtttct
    13801 ttgggatagg gtttcttctc cagaatgtcc atagccagtt gcagtacctt atcgccattg
    13861 gtcggataga taaaggtggc atccagcaca ctgtccagta ccagttccag tccgtttccc
    13921 ttacccggca aggcatctat gccgacaaaa atcatttcct tctcccgccc tgccatcttt
    13981 gctgcctgat aggcacccgg agcgatacgg tcattatggg catacacagc atcaatctta
    14041 ggatgcttcc gaagcatact atccatttct atctctgccg gaccacgttc ccacgcagca
    14101 tccgctttat caatcagctt tatatccggg aatttactga tggcagccat aaatccctga
    14161 tgccgttcca ttgcaggagt cgaaccgctc aatcctgtca gttctactat atttcccttc
    14221 ccttttagac tggaggcaat atagtttcct accgaacgac cgatttcata attatcggct
    14281 ccgatatagg cagtatattt atccgaaaga atcttccggt ctacaagaat aacggggatg
    14341 cctttctgat aagcttcttc tacaatcgga gtcataggag cagcttcgtt agcggaaata
    14401 atcagcagat cgactccttc gtccataaaa taatggacat cttccgcctg cttactgtta
    14461 tcatcccctg ccgaacggat ttccaccgaa acaccattat aaaacatcgc ttcccgaaga
    14521 atctcatcat tcatcttatg tcgccatgaa tcatcgctgc attgagccac cccaatacga
    14581 aaacggggtg tatcctgccg gcaagccgtc atcccgatta aaccaaacag caccagcatc
    14641 cacttcagat atctcatcgt cttcatccat ctcatcattt catagttctt tctgtaatcc
    14701 aattaagaac aaaaataaga aataatactg taaagttctc taacttcagc tatttattat
    14761 tctaaaaaga aggaaagcag tcctctttca gaccatcgga aagtatcaac aaaagtataa
    14821 agcgtaaaac aaacacttaa tcaatgttat aaaacatagc gttttacttg gataatttgc
    14881 agatttcaca gaagtccgta tctttgcact gtgtttttca tagtattaga tttaaggtta
    14941 acaaaggttg gagcaaggcg ttgctccttt ttttatgccc tgacctttca tctaccggtt
    15001 agttttcatc ccattccttt tccagtttac catcaatagt gtagcgtttc catcgtccta
    15061 cacggcgacc attcttatat tccccacatt cacgaagctg gtcattcttt acataacgag
    15121 cttcgaacgg tccgttctgc cttccgttca cataggtaga agtttcccaa taatcaaagc
    15181 ggttgctcac tatcagccgt cgttccttgc catgcaatct gccggcctga taggtagctt
    15241 catatctcaa ttcaccattt tccagattat attcacggta taaaccgtct ttacgatcgt
    15301 tcttcatata atattctttc tgccttaccc cacttccgtt ggcaaatgag acatggagtc
    15361 catcttcttt tccatccaga taggtttcaa tcatcagcgt atctccgctt tcagcaaaag
    15421 tagtccaccg accattcttc tttccattct tataactacc cagtatacgt ggcgagccaa
    15481 acgtaaacac ggacgaatat tcaccgtcct gcaaaccttc ttcattgaaa taaacggtct
    15541 catacaaatc atatgtacct ttcagaaaag tatactgttt gcctacctgc ttcccgtcct
    15601 tgtaattatg ctctttccgc aaagtaccgt cagattcgta cgacagttgc ttcccgtgct
    15661 ctttccccat ccggaagttt ctttcacttt ccacttttcc ggtagtaaag taacttttgc
    15721 tcgtaccatc cagcttacct tccttatagg acttttcttc tttcagctta ccgtcaaact
    15781 tggagttaat cttgaagagg ccatccttcc gcccttcttt ataacttcct tccgttatta
    15841 atatattgtc cacatattct ttgtatccgc catcataaaa accatcttta aaagatgcca
    15901 gcacataggc ggaatgataa ccatctatga tgcgatgttc gccattcaat gctttttccg
    15961 ttttcagttc ctgaaacaac agtctgccat cacctacatt aacaacagat acctgatcga
    16021 tcttatattc cttttgcgca aacaaaggaa gagcaagata taaaaacaaa aatacgttcc
    16081 agttttttga tctgaggaag ttcgaaatgt gtttcataaa gtagttttct ctttttgatt
    16141 tattatttaa aaacctgccg caaagatagg caatcggctt ataaaacaag gcaaggaaga
    16201 gggggacaat tagaaaaaag aacatctgtt attatcattc taataattaa cagattaagt
    16261 agtaaatcaa aacgcaggga agggggacat ttactgaaat aagaaacaga aaagaaggtg
    16321 tgtcaaaagc aactaaattc ccctccttcg ggaaggaggg gaatttagtt gcttttgaca
    16381 caccttcttt ttgaatttaa agagattcta caacaatctg tctttcagaa caaccggaag
    16441 ttcgggcatt gcaccgctct gcgtacaaac ataagcggaa acttcgacag ccagcttatg
    16501 agcttcggga acagacttgc cattcagaat ggaagcacag aaagcggcag taaaggaatc
    16561 ccccgctcc
//
