LOCUS       gnlProkkaIEDGJIHM_182  11543 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IEDGJIHM_182.
ACCESSION   gnlProkkaIEDGJIHM_182
VERSION     gnlProkkaIEDGJIHM_182
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 13:03:57
            Original ID  :: gnl|Prokka|IEDGJIHM_182
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11543
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11543
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[2229:6543]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2230..6543
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..11543
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11543
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             3..1007
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 41.5;
                     E-value: 1.1e-12)"
                     /gene_kind="transport"
                     /locus_tag="ctg182_1"
                     /transl_table=11
                     /translation="MYIPSIHDLEDRGNVTVHGEVAHPDSYPYADNMTLEDLIIQAGGL
                     KEAASTVRIDVSRRIKNPRSIADNDTIGQMYTFSLKDGFVIDGQPGFILQPYDEVYVRR
                     SPGYQAQQNVAIEGEILFGGNYAMTSREERLSDLVNKAGGPTNYAYLRGAKLTRVANAS
                     EKKRMGDVIRLMSRQLGEAMIDSLGIRVEDTFTVGIDLEKALSNPKSNADLVLREGDVI
                     SIPKNTNTVTINGAVMVPNTVSYMKGKNVDYYLNQAGGCSDNARKSKKFIVYMNGQVTK
                     VKGSGKKQIEPGCEIIVPGKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             1018..2166
                     /locus_tag="ctg182_2"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             2230..2949
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 54.5; E-value:
                     1.6e-16)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg182_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 2.5e-16, bitscore:
                     50.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             2970..4271
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg182_4"
                     /sec_met_domain="CTP_transf_like (E-value: 3.1e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 3.2e-121, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 3.6e-63, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             4288..5412
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg182_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.7e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.4e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             5422..6543
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg182_6_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg182_6"
                     /sec_met_domain="Aminotran_5 (E-value: 2.4e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        5512..6519
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg182_6_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg182_6_Aminotran_5.1"
                     /locus_tag="ctg182_6"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             6540..6683
                     /locus_tag="ctg182_7"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             6886..8370
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg182_8"
                     /sec_met_domain="Polysacc_synt (E-value: 2.1e-31, bitscore:
                     99.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLS
                     FLFKLDSFFCILTLIIKTKNIDENIKKDFSSNSKDN"
     CDS             8324..9583
                     /locus_tag="ctg182_9"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             9592..10341
                     /locus_tag="ctg182_10"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKNSK"
     CDS             10341..11381
                     /locus_tag="ctg182_11"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 tcctttacat tccgagcatt cacgatctgg aagatcgtgg caatgtcaca gttcacggtg
       61 aagtcgcgca ccctgattcc tatccctatg ctgataacat gacacttgag gacctgatca
      121 tccaggccgg tggcttgaaa gaagctgctt ctactgtccg cattgatgtg tcgagacgaa
      181 tcaagaatcc ccgtagtatc gcggataatg atactatcgg tcagatgtat accttctctt
      241 taaaggatgg ttttgtcatc gacggtcagc ccggttttat ccttcagcct tatgacgaag
      301 tttatgtccg tcgcagtcct ggctatcagg cacaacagaa tgtagccatt gaaggtgaaa
      361 tccttttcgg aggaaattac gccatgacca gccgtgagga acgtctttcc gatttggtga
      421 ataaagccgg tggtccgacc aattatgcct atctgcgtgg tgcaaaactg acccgtgtgg
      481 ctaacgctag tgagaagaaa cgtatgggtg atgtaattcg ccttatgagc aggcaattgg
      541 gcgaggccat gattgactct ttgggtattc gtgtcgaaga tacctttacg gttggaattg
      601 atttggaaaa agccttgagc aatcctaaaa gtaatgccga tcttgtctta cgtgaaggtg
      661 atgtgatctc catacctaag aatactaata ctgtaactat caatggtgct gtcatggttc
      721 cgaatacggt ttcttatatg aagggaaaga atgtggatta ttacctgaat caggccggtg
      781 gctgttctga taatgcaagg aagagtaaga agttcattgt ttacatgaat ggtcaggtga
      841 cgaaggttaa gggtagcggt aagaaacaga ttgagccggg gtgtgagatt attgtgcctg
      901 gtaaggctaa gaagaaaggg aacatagcta atattttagg ttatgctact tccttcagtt
      961 ctttgggaat gatgattgct tctattgcta atttgataaa gaaataaatg acctattatg
     1021 attgaaaagc aatcttatca agaaccgttt tctgaagtgg ataaaaggaa agatgatgaa
     1081 atggaaatag acttgatggc tattttttat aagattatta ctgttcgtgg agtactatgc
     1141 aaagctgctg gagtgggagt aataattgct atagtggtgg cattgagcat tcccaagcaa
     1201 tatacagtaa aggttaccct ttctcctgaa atgggtaatg cgaagggaag taatggttta
     1261 gccggacttg ctgcctcgtt tttgggagat ggggctctaa taggggaaag cacagatgcc
     1321 ttgaacgctt ctctttcagc agatattgtt tcttcaactc cttttttatt ggaactttta
     1381 gaaatggaag tctccgtttc taaaaaggat gataaaatga ctttggggtc ttatctcgat
     1441 gaagagtcat ctccttggtg ggattatctt ataggttttc cgggcatagt aataggagga
     1501 gttaaatcat tattcggaga agatacggtt cctgccagtg gagggcggca aggaactatc
     1561 gaattgacga aagaagtaaa tgagaagatt aattttctta aaaagaagat tagtgcatcc
     1621 attgataaga aaaccgccat aacgagcatt acggtcacct tacaaaatcc gcagatcact
     1681 gcggttatag cagattctgt cgttcataaa ttacaggaat atattattgg gtatcgaact
     1741 tcaaaagtaa aagaagactg tgcgtatttg gaacggttgt ttaaagaacg tcagcaggaa
     1801 tattatgctg ctcaaagaaa atatgcggat tatgtagacg cccatgataa tgtggttctt
     1861 caaagtgtac gtgctgagca ggagcgttta cagaacgaca tgagtttggc ttatcagata
     1921 tatagtcagg ttgctaatca gttgcaggta tccagagcca aagtacagga ggaaaagcca
     1981 gtctttgcag tagttgagcc tgccgttgta cctttgaaac cttcaggtat gggactcaaa
     2041 atttatattt tattatttgt gttcctgtcc gtatctggta ctctcgtgtg ggtgtttttt
     2101 ggcaaaagtc tgctggctag cttgagaaaa gaactgaaaa ataaggagat agaacaggat
     2161 aaatgatgct aaaacgtcgt ttacaacatt cttacatcaa ttaaattcac ttactatatt
     2221 attaaacgaa tgatacgtac agctatgata atggctgcgg gcatgggaac ccgttttggc
     2281 caatatacag aattgatacc taaagggttc gtcaaagtgg gaggtattcc aatgatagtt
     2341 cgttctattg atactttgtt atcatgtgac attgagcgaa ttgtaatcgg tacaggatat
     2401 aaacaagaag tttatgaaga attgaagaca gactatccta tgcttgaaac ctgttttagt
     2461 cctcgttatg ctgaaacaaa tagtatgtat actttatata atacgcggga gattctgggc
     2521 aatgatgatt ttttattgtt agagtcagat ttgatttttg agaaacaagc aataatgagc
     2581 ttattggagt gtcctgcggc agatgcaatg ctaataactc cagtgacaaa gtttcaagat
     2641 cagtattatg tggaacatga tgataatttt cgcctttctt catgttctgt caataagaat
     2701 aaactaaacg ctaaaggcga attggtcggc atccataaac tatccggttc cttttacaaa
     2761 ataatgtgtg ctgattatgc gagtattgtt gatgaacaac ccaatttggg atatgagtat
     2821 gaattactac gaatatcttg ttctcaatct cctgtttatg tgcataaagt agaagggctg
     2881 aaatggtatg aaatcgatga catatcagat ttggaatatg cagagaaata tattgttccg
     2941 tattgttaat taaaataata tatcaaatta tgagtaagac agtttatatt gggatgactg
     3001 cggatattat gcatccagga cttatccgca ttattaatga ggctactaaa tacggtgatg
     3061 ttataattgg tcttcttaca gataaagcta ttgcggagca taaacgcctt ccttatctga
     3121 cctatgaaca acgaaaagag gtagttcaga atattaaagg cgtatgtaaa gttgttcctc
     3181 aagaagaatg gagctatgtt gagaatctca aacgcattaa acctgactat ataattcatg
     3241 gtgacgactg gaaaaccggg cctttacgtg aagaacgtgt gcgcgtattt gaagtgatga
     3301 atgaacaggg aggaaaggtt atcgaaattc catatacttt gggaattaat tcatcttctt
     3361 tggataaaga tattaaggct ataggtacaa cccctgatgt acgtttaaaa tcacttcgtc
     3421 gtttgataaa tgccaaaccc gtagttcgta ttttggaagc tcatgatgga ctatgtggct
     3481 tgataattga aaatcaggaa atattaaaag gggataagag ggaagtattt gacggaatgt
     3541 ggtctagtag ccttacggat tcaaccagta aaggtaaacc tgatattgag gcggttgatt
     3601 taactacccg attgcaagat ttgaataata ttctggagtg tactactaaa cctattattt
     3661 ttgatggaga tacaggtggt aaaattgaac atttcgtatt tacagtacgc actttagaac
     3721 gtcatggaat ttcagctata ataattgaag ataaagttgg attaaaaaag aattcattgt
     3781 ttggtacaga tgttattcaa actcaagata caatcgaagg tttctgtaat aagatcaaag
     3841 caggaaaggc atctcagatt actgatgatt ttatgattat cgctcgtatt gagagcctta
     3901 tagcgggaaa gccggtaagt gatgctttag agagagcttt tgcatatgtc caagcgggag
     3961 cggacggtat tatgatacat agcaaaaata agtcgggtga agatataaaa gaattttgtt
     4021 tggcgtttcg aaaacagtat gctcatgtac ctatcgtggt tgtgcctact acatatgatc
     4081 atatttatga gtctgaattg tgtgattggg gtgtgaatat aattatttat gctaatcata
     4141 tgcttcgtgc cgcttatcct gctatgatga atgtcgcaaa gataatatta gagaatgaac
     4201 gtgctttaga ggtgcgcgaa ctgtgtatgc ccataaaaga aatattggaa ctgattccag
     4261 gtactaaata aaaagaggaa tatcattatg ttaagcgtag aaaaagttta tgaaacgttt
     4321 ctgagtcatg acgttgattt ttttacagga gttccagact cattactaaa aaatatttgt
     4381 gcctatatca cagaccatac ttcacgtgag aaacatatca tagctgctaa tgaaggtgcg
     4441 gctgtaggaa ttgcttcagg ttattatatg gcatcaggta aggttcctgt ggtttatatg
     4501 caaaattccg gcttgggtaa tactgttaat cctctgctgt ctcttgcaga tgaacaagta
     4561 tacagttttc caatgctttt gatgattggc tggcgtggtg aaccgggaac aaaagatgaa
     4621 cctcagcata aaaaacaggg tgaggtaact ttagatttgt tgaaagcaat gcggattcct
     4681 tatataattc ttgattcaaa tgagaatgat gcatttattc agctccatga tatcatacaa
     4741 tcagcaaaaa ctaagaatat tcctcatgca ataattattc ggaaagatgt ttttggcaaa
     4801 tataaacttc aaaaagagtt cggatgtaat tatcctttat ctcgtgagga tgctttgcaa
     4861 atagttgtgg attatctgcc tgaaaattca gtggtcgttt ctactactgg caagctttct
     4921 cgtgagttat ttgaatatcg agaaatgaaa gagcaaggtc atgaacatga ttttctcacg
     4981 gtaggctcta tgggacatag ttcatcaatc tctttgggta ttgctatagc aaagcaagat
     5041 agacctgttt attgcttgga tggtgatgga gcatttatta tgcatttagg ggcaattagt
     5101 aacattggcg atttatctcc taaaaactat tatcatattt tgtttaacaa tggtgctcac
     5161 gagtctgtag gaggacagcc tactttagga tttagtttag atattccggc tattgtccgg
     5221 gggagcggat ataagcatac ttatactgtt tgtacaaaag ttgaaattga agaagcaatg
     5281 aagcagcttc caaagttatg tggtcctgtt ttgttggaaa taaaggttaa aatagattct
     5341 cgggagaatt tgggacgtcc cacgactact cctatagaga ataaggagca ttttatggat
     5401 tttttaaaat aaatatattc gatgaaaata gaaagaaaaa tattattaaa tcctgggcct
     5461 gccactacta ctgacagtgt aaaaatggca caagttgttc cggatatttg tcctcgcgag
     5521 aaagaattcg caggtatgat gaaacaactt cgggacgatt tggtcagagt tgctcatggg
     5581 aatttggaaa aacataccgc tgtattattt tgtggctcag gaaccatcaa tattgatata
     5641 tgtctaaatt ctcttcttcc tgaagacaaa agggtgctta tagtgaataa tggggcatat
     5701 agtacccgtg ctgtagaagt gtgtcaatat tatggtttgc ctcatattaa tttggaattt
     5761 tccgtttacg aacgtcctga tttatcggtg gtggaaaatg tgttgcaaga aaatcctgat
     5821 atagctatgg tttatactac tcatcacgag acgggtacag gaattctgaa ccctattcgc
     5881 gagatgggcg ctatagctca taaatatcag gctaaatttg tcgtcgatac tacttcttct
     5941 ttgggcatga ttccttttga tatagagaaa gataatgtgg atttttgtat ggcatctgct
     6001 caaaaaggac ttcaagcgat gacaggtctt tcttttatta taggcaatga ggaacagatt
     6061 aagttttcaa aaaaatatcc caagcgttct tactattgta atctttattt gcagtatgag
     6121 aattttgaga gaacaggtga aatgcatttt actccaccgg tacaaactat ttacgccact
     6181 cgtcaggcat taaatgaata ttttgaagtg ggtgaagaag ctaagtttgc ccgtcacaaa
     6241 agagtttttg aggctattca ttcaggtata aatgaaattg gtcttaaaag tgtaataaag
     6301 cgtgaatggc agtcaggact ggttgtctca gttcaatacc cagaagatcc caactgggat
     6361 tttgagaaaa tacatgatta ttgttatgag cgtggattta cgatttatcc aggtaagata
     6421 tcaactgagg atacttttag aatctgtgct ttaggagaga tagaagtaga tgatattgag
     6481 aacttcttta aagtactaaa agctgcatta aatcattata acgtcacatt accgatgtca
     6541 tgattgcaga aatattattg aagattcgtc atttttattt ttcccttcgt ggtatacact
     6601 tccatccgga aagtgttatt tctggagtgc ctattcgtag ctttcgctta gtaggcaaat
     6661 atggcaatat taatttgagg tgatgcatta ggagttcttt attcttataa aaaggcatcg
     6721 gtagttatag gagataatgt ttgtgtaggg taatttgctt ttagtgggag agaccatatt
     6781 agaattgcgg taaggggcga agaagataat aaccaattag tgagaatatt ggaaaaatat
     6841 aattgatatc ggtaaatgta gttgttttta tactgtattt aagtaatgga aaatctaaag
     6901 cagaaaactg tatcaggaat aatgtggagc gctatagaac gtttctcttt acaaggagta
     6961 cagtttataa ttcaaataat attagctcgt ttgttactac catcggatta tggtatgatc
     7021 gggatgttag ctatttttct tcaagtcgct caagtattta tagatagcgg ttttacaaat
     7081 gctttaatcc agaaaaaaga tagaactgaa gaggattttg ccactgtctt ttattttaat
     7141 attcttgtcg cagtattatt ctatggtata ttgttttttt cggcttcttt gattgcagac
     7201 ttttataata tgccgacttt agttcttgta attcgtttta tagcattgtc gttgataata
     7261 aatgctttat cggctattca cagaacgaaa ttaattattt ctgtaaactt taaaactcaa
     7321 tctaaaattt cattaggtgc agcttttata tcaggcgtga ttggaatatg gatggcttat
     7381 gtcggttgcg gggtttgggc tttagtttgg caaactctct taaatagtat aattttgaca
     7441 attttgtttt actgtttagt tcattggaaa cctttacata ctttctccaa aagttctttt
     7501 gaaagattat tcaatttcgg atctaaatta ttgatctcaa gtcttatcaa tacagtatat
     7561 cgtaatctgt ataccattgt aataggaaaa aagttttctg ttgtagagct tggttactat
     7621 acaagagcag aacaatttgc tatttttcct tccaataatt taaatgcttt agtttctaga
     7681 gtagcgtatc ctattttaag ttccattcaa gatgatgata aatgtttaac aaacgcatat
     7741 cgaaattata tcagattatc ctcatatata atttttcctt taatggtagg tttacttgtt
     7801 ttggctaatc ctattattag tctattgtta acagataaat ggtctggggt tgttattctt
     7861 ttacagatat tatgtttgga ttggatgttt gatcatttga gccaaattaa tttgaattta
     7921 ttatgggtta aaggaagatc tgatctgtcg ttacgtcttg aaataataaa aaagacgatt
     7981 gctatattca ttctttttgt gtcaattcca tttgggcttg aggtgatgtg ttggggtaga
     8041 gttatttact ctctgatagc gacatatttg aatacatatt atactaattc tcttattgat
     8101 ttgaccttaa agttgcaagt taaagatgta tttccaagtt taatactctc tttcataatg
     8161 ggggggatcg tttttatatg tatttctttc tttgaaactg atatagtaaa aattgtgatt
     8221 ggatgtatta ctgggatgtc cttctatatt ttactttctt ttctttttaa gctagattct
     8281 tttttttgta ttttaacatt gatcattaaa actaaaaaca tagatgaaaa tattaaaaaa
     8341 gatttttcaa gtaatagtaa agataattaa ccattgtgtg ccagttgata gtagatcatt
     8401 gtattttatt cctcatccta attgtagaac agataaatat gatattataa attattcgtc
     8461 agataatgtt ctcgttctgt taaattattt gctaaaaaaa gatagtgctg aatattataa
     8521 aatatatgtt gaaatttatg attcttctcg tatttcagaa tatcaagaat atatttatgg
     8581 cataaatcct aatattaggt gtactttttt atgtgcatgt gttggacgtt ttttctttaa
     8641 taaagtatct tttaaggata tgttgtatgc ctttttttgt ttttgtagag caagtaaatg
     8701 ttttacagct actttttatt atgatttttc atttaaaaaa cgctctcaac agattatttg
     8761 tttggggtat tatactccat tcaaagatga ttatcatatg ggagatcatt cttatgataa
     8821 atttcgtaat acaacatgta actcatttga ttactctatt gctacttctt gtttaagtgc
     8881 tagaataatt tcaatagatt gtggaatctc atatgataaa ttcaaagtct taggatttcc
     8941 cagaaatgat ttgttgatat cgaaaaataa ttgcaatgtt attaaaagag aaatttcgaa
     9001 atttgcggga tatgatgtaa ctaaatatat agtttatact ccaacttttc gtgattatga
     9061 gactgttact gaaggtaatt tgcgttcaat actcggatat gttgattgtg atttgttgaa
     9121 gttatcgaaa atactattga agtttaatgc ggctttaatt cttaaattac atcctttgca
     9181 gaataaaaca gtcttaaaaa aagatttacc caaaggtata cttgtttttg aacaaacata
     9241 taaatatgga ttgtatgatc ttttgtcatt ttcagatgga atgattactg attatacttc
     9301 tacctatttt gattttttat tggtaaataa gccagtcata tttaatttct acgatattga
     9361 agaatatcgt agagtaagag gtttctcatt tgagccaata gaattttttt gtgcaggtga
     9421 tattgtttac aattataatg aattgataga tgctgtgatg ggacttctgg ctgggaaaga
     9481 tattcatgct gaacatcgac gtcatatttc tttattgatg aatcaatttc aagatgataa
     9541 ttcaacaaag agaatatgtg acatattttt aaatgaaata taataaataa aatgaattat
     9601 gcatttgtgg tgcaggcacg tttaggttct acacgtttgc ctggaaaaat attgaaacct
     9661 ttctatggta atcaatcgat tcttgactta atggttcata agctttctgc tatatcgaat
     9721 attccagtaa ttattgctac aacaaattct gttatcaatg aacctattga aaagaaggca
     9781 cttgcattag gggtaaagtg cttcagaggt gaggagaatg atgttttaaa acgattcatt
     9841 gatgttgctg aatattttga tatacagggt atattccgaa tatgttctga taatccattt
     9901 ttagatgtac atgcggcaag gcaattggtc gaaatagcaa tgaaatcttg taacgattat
     9961 ataagttttg atattgatgg tactccatca attaaaactc atttcggttt ttggggagaa
    10021 tttgtaacgc ttgatgcgct gaagcgagtt ataggattta ctgatgattt attgtatcgt
    10081 gaacatgtta ctaattatat atatagtcat cctgaacttt ttaatattca atggatttca
    10141 ggatctccag tcgtgtcaaa acatcataat attcgactca cgattgatac gttagaagat
    10201 ttttctgtag cacagagaat atatagggat ttacaagaaa aaagagtgga aatatcgata
    10261 gaagtgattg tagactatgt tcgaagacat gcagaataca ttcaactgat gaaacaacaa
    10321 ataaaaaaaa attctaaata atgaagaata cttatattat tggtgaaata gggcagaatc
    10381 ataatggttc tgttgacttg gctaagttga ttattgaatt aatctcacga cctgtacatg
    10441 aggatgtttt tggtatggat ttcatgccaa tgaatgctgt taaaatgact aaaagagatt
    10501 tatcagaaga attggctgtt tctcaaatga atcaaatata tgacaatcct aattcttttg
    10561 ggcgtactta tggtgaacat cgtgcttttc ttgagcttga tgatcaagcg cattttgaga
    10621 tttataaata tgctaagtca ttaggattag attttatcga gacgttatgt gccaaaggat
    10681 gtctgtcttt gcttaaactg ttcacaccgg ataggctaaa agttgctagt cgtgatttga
    10741 ctaacttacc attgcttgaa gcattagcag aaactcatat tcctattata ttatcgacag
    10801 gaatggctgg tcaaagagaa cttgacaatg cattagatgt gataacgaga tatcatagta
    10861 atatagctat tctacattgt gtatctcagt atccaactca tccaaataat ttgaatctac
    10921 gtacaataac atatttgaag aagcattaca ataagtttga gataggtttt tctgatcata
    10981 caataggtat ttctgctgct acagctgctg tagcgatggg agcggaaatt atagaaaagc
    11041 atgtaacaat tgatcggcat atgaaaggaa cagaccagct tggctcttta ggtccagatg
    11101 gggttaatcg tatgattcga gatattcgca tagcagagtg ttggcttggt actgaagatc
    11161 tttatataga aaaaggggtg gagaagtcta agataaaact tgaacgttct attgccactc
    11221 gaaaatatat tccagcaggt agtattattc aagagtcgga cattcattta ctgagtcctg
    11281 gtgatggtta taaatggata gataaaaaaa atgtaattgg tcattttgct aaacaagata
    11341 tatcagcgaa tgaaataata tatcctgatt ttattgaata gatatattcc tactgcaact
    11401 tgtattacgg tatagagtac tgcctgctat aagctaagta gtgattaata aataagggta
    11461 aaatactaaa aaaatgaaag agataaagct tatacttaca gatattgatg gcgtttggac
    11521 tgatggcgga atgttttatg atc
//
