LOCUS       c00071_gnlPro..        13866 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IEDGJIHM_71.
ACCESSION   c00071_gnlPro..
VERSION     c00071_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 21:40:13
            Original ID  :: gnl|Prokka|IEDGJIHM_71
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13866
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13866
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1725:6184]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1726..6184
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..13866
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13866
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             3..137
                     /locus_tag="ctg71_1"
                     /transl_table=11
                     /translation="RKTFAEKPAEFDPRKYLGPARDNMEKLYKHKILNVLGSDNKLAE"
     CDS             complement(217..1551)
                     /locus_tag="ctg71_2"
                     /transl_table=11
                     /translation="MKRIILLAFLCTTTLVMAQRINHVQEAIANYDYEAALTLIAKEKP
                     TIPLLLQKGKAQRGLGMNTEALSTYQEIITNDTANTRAYIEAAECCRSLAKYQQALKYY
                     EQALDLNPENKYVRIQYIGLLLSLQKFQDALGESSLMTEKDSSAIALHLQAQSFEGMGE
                     LLPATGCYYNIQEKYPDDYLAAAKLAALNIAGSYFNEAIEATEKYRQIDTTNIAVNRQN
                     ALAYCLNKDYPTAIQRYEYLVSQGDSSFHTCYYLGISYYAEEKYYEAHDFLEAARKHDP
                     ENVNLLYYLGRACAKTSWKKLGVEYLEKALDLTIPKDSNMVRLYIGMTDCYKMAQMPKE
                     QIESIRERYRKYDKQNHKLLYDMAFIYFYSLKDKKNTERCLEAFLKTRPKEDKEEEAKL
                     NERGELVLGTKNYYNAAANWLKDIQSKQKIEDFFLGGNVPAQKPE"
     CDS             complement(1726..2886)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg71_3"
                     /sec_met_domain="OAD_beta (E-value: 1.4e-153, bitscore:
                     500.7, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFINFLGNNLADFWTYTGFANATGGHIAMIIIGLGFIYLAVAK
                     EFEPMLLIPIGFGILIGNIPFNMDAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALEMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKHERVIRMKPPRAVSHTEKVIFP
                     IIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDTITILLGLTVGAS
                     TQASEFLTLDSIKIFALGALSFIIATASGVIFVKIFNLFLKKGNKINPLIGNAGVSAVP
                     DSARISQVVGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             complement(2888..3322)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 66.7; E-value:
                     4e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg71_4"
                     /sec_met_domain="Biotin_lipoyl (E-value: 8.5e-22, bitscore:
                     66.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNSYKVTIGDIEDNIAHVEVNGTHYKVEMEKQPKTA
                     PKPAVVRPMPNSPAAPTTPVVKPAAPSTGKSGVKSPLPGVILDIKVNVGDTVKRGQTII
                     ILEAMKMENNINADKDGKVTAINVNKGDSVLEGNDLVIIE"
     CDS             complement(3347..4267)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg71_5"
                     /sec_met_domain="OAD_gamma (E-value: 7.2e-16, bitscore:
                     48.5, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLLLLIGLTSCGEQKSNNKLVLNEILIDNQSNFQD
                     DYGLHSAWIEIFNKSFGSADLAACLLKVSSQPGDTVTYFIPKGDILTLVKPRQHALFWA
                     DGEPNRGTFHTSFKLNPETANWIGLFDSGRKLLDQIVVPAGVLGPNQSYARVSDGAAEW
                     EVKGGSGDKYVTPSTNNKTLDSNAKMEKFEEHDADGVGMSISAMSVVFCGLILLFIAFK
                     IVGKVAVNLSKRNAMKSKGIDKHEAKELSQAPGEVYAAISMALHEMQDEVHDVEETVLT
                     ITRVKRSYSPWSSKIYTLRETPPRK"
     CDS             complement(4299..5654)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg71_6"
                     /sec_met_domain="CT_Btheta (E-value: 5.5e-267, bitscore:
                     875.7, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKKHYPGDGVVTGCGTIEGRLVYLFAQDFTVTAGSLSETMSLKI
                     CKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQISGIFGPC
                     AGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHSTKSGVTHF
                     TAKTEEEGLALIRTLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDSPNKPYDMYE
                     VISAIVDNGEFLEIQKDYAKNIIIGFARFNGQSVGIVANQPKFLAGVLDSNASRKGARF
                     VRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTITLRKSYG
                     GSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKDQENPAQFLAEKEAEYT
                     KLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLSNPAKKHGNIPL"
     CDS             complement(5621..5749)
                     /locus_tag="ctg71_7"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERXXXXKWTCSLSTDARTSAWRKSTIRVMV"
     CDS             complement(5780..6184)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg71_8"
                     /sec_met_domain="Glyoxalase_4 (E-value: 1.4e-24, bitscore:
                     76.4, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGETKIELLEPTCPESTIAKFIENKGAGVHHVAFAVEDGVANALAEAESKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             complement(6358..7356)
                     /locus_tag="ctg71_9"
                     /transl_table=11
                     /translation="MPLKLTTYYRGKDIPDLPGTNTFHSKELFQIYESTPGYTPLLIVA
                     TEEGRPVARLLAAIRKTKKWLPSSLVKQCVVYGAGEFLDTSLPASKEKEEEIFGEMLEH
                     LTQEASRTCILIEFRNLDNSMFGYRFFRKNDFFPVNWLRVRNSLHSTQKAEDRFSPSRI
                     RQIRKGLKNGAKVVEAHTVEEIKEFSRMLHKVYSSRIRRYFPANDFFRHMNSMLIRGKQ
                     AKIFIVKYKEKIIGGSVCIYSGENAFIWFSGGMRKTYALQSPGILAVWKALEDAHERGF
                     RHMEFMDVGLPFRKHGYRDFVLRFGGKQSSTRRWFRISWSWLNNLLVKFYV"
     CDS             7605..10799
                     /locus_tag="ctg71_10"
                     /transl_table=11
                     /translation="MRENAFVEAWKTQHRRVSMILGLTLLCAPSAISVYAENGVNDITV
                     QAVMQTKTVKGTVLDENGEPLIGVSIVVKGTSTGTITDFDGKFSINLPAGSKELVVSYI
                     GYKEQAIIVSGNAPLNIKMVPDTQALDEVVVIGYGTVKKRDLTGAVASVKSEDITMNPG
                     VNPMDALQGKIAGLDITNSSGQAGSSPTVQLRGTRSLQLDEDGNISSDAFKPTYIIDGM
                     PGDIATLNPNDIESIEVLKDASSTAIYGSSGANGVIIVTTKGSKSGKPVINFNAYAGTT
                     MGARVPKMRTGDSYINYIKDSYKPVGTTNEEEIFGERYDAIKNNQWVNWGDEVLHSGLK
                     QNYSISVAGGTEKTKAYFSLNYTDEKSMYENDDYKVYSTRVRIDQEINKWMNAGINVQA
                     SFSNKNSRNAVLERALFATPLGTPYNEDGSITEFPIPGSSSDPNPLADEQDGVYKNNTK
                     AGRAYVDAYLEWKPVKGLSVKSQLGGSYSQSRAGKFMGEGSYNVLKGSTVAYGEATNKT
                     GYNYKWENIVTYHNTFNKDHDLTVTGVTSWNYNQSEEYYVYGENPATNDMLWYALQNAD
                     NKKLNSKYLMSKGMGFIGRVNYSYKGKYLFSASSRYEADSRLSKDNRWNLFPAVSVGWR
                     ISDEAFMAGTKSWLDNLKLRVGYGVAGTTAGIAEYSSMASLENVTTSLGGMTVPSAKFT
                     EYITNRNLTWEKTHDLNIGIDASFLNNRIDLTVDLYRTKTTDVILSQALPTSIMGNYTG
                     STTYKMNKNAAETENRGIELALNTRNIVKKDFTWSSTVTFTANKEKIKSLIEGQDMMFN
                     AKKGDMVFKVGEGVGSFYRYKVLGIWQYSEKETAALFGCEPGDIKLDLPSVKKDGNGYY
                     YMNPEGERVDITAENPYGVRADYDRQVIGRNTPDWTLGFKNNFRYKDFDLSVFLYARWG
                     QMMNYGSVIGKYSPNPDYNIPTYFTYYDKTIEADQDVLFYAIDKSKDRSAYEGYDSMYY
                     VDGSFFKLKNVTLGYTLPGKLTKRFGISNLRVYATMTNLFTYSPNKYVKNYDPEMNGSI
                     NFPLSRDCIFGLNLTF"
     CDS             10811..12766
                     /locus_tag="ctg71_11"
                     /transl_table=11
                     /translation="MKKIYSLVLLVAGVFSWGSCSLDEVNPNNSGQFSDGSYTLETYKA
                     FTNSCYTALINNIYQSSDYLVCTEAGTDIWEEPKSGSSYQRYHSYNGMKTDDSYYYKVW
                     QYSYLCINSCNIVIDGAENVTGDETEINECVAQARCLRAYYYMNLVEQFGNVDLQLKAA
                     DSENISFDAHRSTVPEIYAAIIEDLKFAVENLPVSFSDYYSRVTKKSAMGLLARAYING
                     AGYDLKDTDGVSFLEKAYDTATTMINNKAIYEWYMHPAFADVFNENNNRNNEEALFIAA
                     GAERNSDAYTNGNYSQSEMFRHFLPSLGTYTDLGLVDKTSNFVYGRPNSNIFLPSKYLM
                     DCFAADMNDSRFRYSFISAYSSYSIPAWGATYEYGGSACAKEITSTLATKFGIPASNIG
                     KKVYPHFNLESNSTADANYCQLAIWNADGTAKTTQDKTDGNILHPAMPLDPAEAHQYAV
                     YCSLKTLTEEEKAQYPGLVLNVFDLYDENGTARATYDKPSAASALWLSIYPALSKFNMP
                     GNKFVGRDVQRKTVDVMIMRMAEVYLIAAEASVRLNKGDAAKYINVLRTRAGAGTVSES
                     QVDLNYIFDEYARELCGECARWYLLKRNAAFETRLAAYNKRAAEHFKKEFYLRPIPTKY
                     LDAINNPAEFGQNAGY"
     CDS             12953..13495
                     /locus_tag="ctg71_12"
                     /transl_table=11
                     /translation="MIEEMLAYNREFVKNEGYKEYITNKYPDKKIAILSCMDTRLTALL
                     PAALGIKNGDVKMIKNAGGVISHPFGSVIRSLLVAIFELGVEEIMVIAHSDCGACHMHS
                     EEMLEKMKARGINADYIHMMSFCGVDFHSWLDGFEDTEKSVRGTVDFIVHHPLIPSDVK
                     VHGFIIDSTTGELTRIV"
     CDS             complement(13609..13794)
                     /locus_tag="ctg71_13"
                     /transl_table=11
                     /translation="MKKRITQDDYIKANRKASREAEIKEHGHPVCYKRVHESKKVYNRR
                     KIKAADKKLPYFFHLG"
ORIGIN
        1 tccgtaagac tttcgctgaa aaaccagctg aattcgaccc acgtaagtat cttggtccgg
       61 ctcgtgacaa catggaaaaa ctgtacaagc acaaaatcct taacgtgctg ggttcagaca
      121 acaaattggc tgaataatca cagattatcc tattatatag aaaggctgca atcgtttgac
      181 ggttgcagcc ttttttacgt aatatccttt atctgcttat tccggtttct gagcgggcac
      241 atttcctccc aagaagaaat cttctatctt ttgcttactt tgaatgtctt tcagccagtt
      301 ggctgcagca ttataataat tcttagtgcc taaaacgagt tcgcctcgtt cgtttagttt
      361 cgcttcttct tccttatctt ctttcgggcg tgtttttaag aatgcttcca gacagcgttc
      421 ggtatttttc ttgtctttca gcgaatagaa ataaatgaaa gccatatcat agagcagttt
      481 atgattttgt ttatcgtatt tccggtagcg ttctctgatc gattcaatct gctctttagg
      541 catctgtgcc attttgtagc agtcggtcat gccaatatag agccgtacca tattactgtc
      601 tttgggaata gtcagatcaa gcgctttttc gagatactct acgcctaact tcttccatga
      661 agtcttggcg caggcacggc cgagataata aagcaggttt acgttttcag gatcatgttt
      721 tcgggcggct tccagaaagt catgtgcttc gtaatatttc tcttccgcat aatagctgat
      781 acccagataa taacaggtat gaaaagaact gtcgccctgg ctcaccaggt attcataacg
      841 ctggatagcg gtaggataat ccttattcag acaatatgcc agtgcattct gacggttgac
      901 agcgatattg gtggtatcaa tctgccgata tttctccgtg gcttcaattg cttcgttgaa
      961 ataagaaccg gctatgttca gtgcggcgag cttggcggcg gcaagatagt cgtcggggta
     1021 tttctcttgt atattatagt agcaccccgt ggcggggaga agctctccca taccttcgaa
     1081 actttgggcc tgcagatgca aggcgatggc ggaactgtct ttctctgtca tcagactact
     1141 ttctcctaaa gcatcctgaa acttctgtaa agagagcagt agtccgatgt attgaatacg
     1201 cacatatttg ttttccggat tcagatcaag tgcctgttca taatatttca gtgcctgttg
     1261 gtatttggcc aatgaacggc agcattcggc tgcttcgata tatgcacggg tattggcagt
     1321 gtcattggtt atgatttcct gataagtgga aagtgcttct gtattcatcc caagtccccg
     1381 ttgtgcttta cctttttgca agagtagggg aattgtcggc ttttctttgg caatgagagt
     1441 gagagctgcc tcgtaatcgt agtttgctat tgcttcctga acatgattga tgcgctgcgc
     1501 catcaccagg gtggtggtac aaaggaaggc gaggagaata atccgtttca taaatattta
     1561 ttttagtgtg tcgtaacaaa gacgcaagat gctaaaaaat atcgtattta cgaattattc
     1621 gtagcctttt tggaatagat taacggaatg ataagagaag ataacataat gataagtgcg
     1681 gatattgcat ctaaaacagc aatatccgca cctaatattt tgtccctaca ttaagaatcc
     1741 taacaggata ccggcagcaa cagccgaacc gattacacct gctacgttcg gacccatagc
     1801 gtgcatcagc aagtagttgg taggatcata ttccagaccg acaacttgtg agatacgtgc
     1861 agagtcggga acagcagata cacctgcatt accgatcaac ggattgatct tattgccctt
     1921 cttgaggaag aggttgaaga tcttaacgaa gatcacacct gatgcggtag caatgataaa
     1981 tgacagagca ccgagggcga agatcttgat ggagtcgagt gtcaggaact cagaagcctg
     2041 agtagaagca cctacggtca aacctaacag gatagtgatt gtgtcaatca gcggaccgct
     2101 ggctgtgtta gccagacgac gggttacacc actttctttc aacaggttac cgaagaacag
     2161 catacccaac agaggcagac cggaaggaac caggaagcag gtcagcaaca gaccgataat
     2221 cgggaaaatc actttctctg tatgagaaac ggcacgtggc ggtttcatac ggataacgcg
     2281 ttcgtgtttg gtggtgagca gacgcatgat aggcggctgt atcaccggaa ctaacgccat
     2341 ataggagtag gcggataccg caatggctcc cattaagtta ggtgccagct tggacgaaag
     2401 gaagatagcc gtcggaccat ctgctccacc gatgataccg atagcaccgg cctgcatcgg
     2461 gtcaaatccc atttccaatg cgatcatgta tgcaccgaag ataccaaact gggcagccgc
     2521 accgatcagc atcagcttcg gattggagat tagcgccgag aagtctgtca tggcaccgat
     2581 acctaagaag atgagcggtg gataccagcc ggacgttact ccctgataca atatgttcaa
     2641 tacagaacct tcttcatata taccgacttt tagtccggcg tccatattga aaggtatatt
     2701 accgatcaga ataccgaatc cgataggaat taacaacatc ggctcgaact ctttggctac
     2761 agctaagtaa ataaagccta aaccgataat gatcatagca atatgtccac ctgtcgcgtt
     2821 ggcaaatccc gtgtaggtcc agaaatcggc aaggttattt cctaaaaagt taataaaatc
     2881 tcccatatta ttcaataatt acgaggtcat taccttcaag aacagaatct cccttgttga
     2941 cattgatggc agtcacttta ccgtctttgt ctgcattgat attgttttcc atcttcatgg
     3001 cttccaatat aatgatagtc tgtcctcttt tcactgtatc acctacattt actttgatgt
     3061 caaggataac gcctggcagt ggggacttaa cgcctgattt gccggtagaa ggagcagccg
     3121 gttttactac cggtgtggta ggagcagccg gtgagttagg catagggcgt actactgccg
     3181 gtttgggagc agttttcggt tgtttctcca tttctacttt gtaatgcgta ccgttcactt
     3241 ctacatgagc gatattatct tcaatatctc cgatggttac tttatatgag ttaccgttga
     3301 ttttatattt atattctttc atcgttttaa ctttttaaaa ggtgacttac tttctgggag
     3361 gagtttcacg caaagtgtaa atcttcgaac tccatggtga gtaactgcgt tttacgcgag
     3421 tgatggtcag taccgtttct tctacgtcgt gcacttcatc ctgcatttcg tgcaatgcca
     3481 tagaaatcgc agcgtaaact tcgcccggag cctgtgacag ttccttagct tcatgcttgt
     3541 caatgccttt agatttcata gcattgcgct tgctcaaatt tacagctact tttcctacaa
     3601 tcttgaaggc aataaagaga agaatcaatc cgcagaatac tacactcatg gcagagatag
     3661 acatgccgac accgtcagca tcatgctctt cgaatttttc catcttggca ttgctgtcaa
     3721 gagttttgtt gttcgtactc ggggtcacgt atttgtcacc acttccacct tttacctccc
     3781 actccgctgc tccgtcgctg acacgagcgt atgactggtt gggaccaaga acacctgcgg
     3841 gcactacaat ctggtcgagc agctttctac cggagtcaaa cagaccgatc cagttggccg
     3901 tttccggatt cagcttgaag ctggtgtgga aagtaccgcg gttaggttcg ccatctgccc
     3961 agaatagtgc atgttgacgt ggcttcacta atgtaagtat atcacctttc gggataaagt
     4021 aagtaactgt atcgcccggt tggctgctta ctttcaacaa gcaagctgcc aggtcggcgc
     4081 taccgaatga tttattgaat atttcaatcc atgcgctgtg caatccgtaa tcgtcctgaa
     4141 aattactctg attgtctatc aggatttcgt ttagcaccag cttattgttc gacttttgct
     4201 ctccacaaga agtcagacca atcagcaaca gcaaagaaag gaatattccg attttggttt
     4261 tgttcataat cgttcttgtt ttaatgtgaa aagttggatt acaacggaat attaccatgt
     4321 ttcttcgccg gattagacag tttcttagtc tgcaactgct gcaaagcacg gatcacgcgg
     4381 aaacgtgtgt tacggggttc gatgacatca tcgatgtaac catacttagc tgcattataa
     4441 gggttggcaa acagttttgt atattctgct tctttttcgg caaggaactg agccggattt
     4501 tcctggtctt tggcttcacg cgcgtacaat acttctactg cacctgcacc acccattaca
     4561 gcgatttcag ctgttggcca agcatagttc atgtcaccac gaagttgttt acaactcatc
     4621 acgatgtgag aaccaccgta agatttacgc aatgtgattg ttactttagg tacagtagct
     4681 tcaccgtaag catacagcag tttggcacca tgaaggataa cgccattgta ttcctggcct
     4741 gttcccggaa ggaatcccgg tacgtctacc aacgacacga tagggatatt gaaagcatcg
     4801 cagaaacgaa cgaaacgtgc gcctttgcga gatgcgttgc tgtcgagtac accggcaagg
     4861 aatttaggct gattggctac aatacctaca gactgaccgt tgaaacgggc aaaaccgata
     4921 atgatattct tggcatagtc tttctggatt tccaggaatt cgccgttgtc tacgatagcg
     4981 ctgataacct cgtacatatc atacggtttg ttggggctgt cggggataat atcgttcagt
     5041 gaatcttcca gacggtcgat cggatctgtg caatccacgt atggagcttc ttcgaggttg
     5101 ttttgaggaa tatagctcag aagtgtgcgg atcaatgcca gaccttcttc ttctgttttg
     5161 gcagtgaaat gagtaacacc cgatttggta gagtgaacgc ttgctccgcc gaggttttcc
     5221 tggcttacgt cttcaccggt tacagttttc acaactttcg gacctgtaag gaacatataa
     5281 gaagtacctt ccatcatcag tgtgaagtct gtcagtgccg gagaataaac agcaccgccg
     5341 gcacaaggac cgaagatacc ggaaatctgc ggaatgacac ccgaagcgag gatattgcgc
     5401 tggaagattt ctgcgtaacc tgccaaagcg ttaatacctt cctggatacg tgcaccgccc
     5461 gagtcattga taccgataca aggagcaccc atcttcattg cctgatccat aatcttacag
     5521 atcttcagtg acattgtttc cgacagtgaa cctgcagtaa cggtaaagtc ctgtgcaaaa
     5581 agatatacga gacgaccttc gatagtaccg caaccggtta ctacaccatc acccggatag
     5641 tgctttttct ccatgccgaa gttcgtgcat ctgtgctcaa cgaacatgtc catttctnnn
     5701 nnnnnnngcg ttcaataagc tctttaattt tttcaagttg attactcatg agttcttgtt
     5761 gtttttttag agtttatgat tagtgttcgc agagttctgt cagcacaccc agtgttgatt
     5821 tcgggtgaag gaaagcgatg ttcagacctt cggcaccttt gcggggagcc ttgtcaatca
     5881 gacggatttc tttgctttct gcttctgcca aagcattagc tacgccatct tctacggcaa
     5941 atgctacgtg atgaacacct gcacctttgt tttcaataaa tttagcaatg gtgctttcgg
     6001 ggcaagtcgg ctccaacaat tcgatttttg tttcacctac ctttaaaaaa gcggttctta
     6061 ctttttgatc ttctactgtt tcgatgttgt aacatttcag acccaatacg ttttcgtagt
     6121 aaggaagggc ttcttcgatg ctttttacag caatgcccag atgctcaatg tgtgaaatct
     6181 tcataactat atttttttat atggtttaat tatgtgctta tatggcataa aacagcacaa
     6241 agaaagacat ttcttgtcta ataaagaaat atttctgcat ttaattattg gggaataaag
     6301 cataaaaaat gctccggatg ggtgacaaag acgggttttg taatcttgag attacattta
     6361 gacataaaac ttgaccagaa gattattcag ccatgaccag ctgatacgga accagcggcg
     6421 ggtactgctt tgtttgcctc cgaaacggag tacgaaatca cgataaccat gcttgcggaa
     6481 gggaagtcct acatccatga actccatgtg acggaatccc cgttcatggg catcttcaag
     6541 tgctttccat actgccagta tgccgggtga ctgcagtgca taggtctttc gcattcctcc
     6601 tgaaaaccag ataaaagcat tttcgccgga atagatgcag acggagccgc cgataatctt
     6661 ttccttgtat tttacgatga atatttttgc ctgttttcct ctgataagca tgctgttcat
     6721 gtggcggaaa aagtcattgg cagggaaata tctccgtatt cgtgaagaat aaactttgtg
     6781 cagcatccgc gagaattcct taatctcttc caccgtatgg gcttctacta ctttggctcc
     6841 gtttttgagc cctttccgga tctgacggat acgtgatggg ctgaaacggt cttccgcttt
     6901 ctgcgtacta tgcagagagt tacggacacg cagccagttg accggaaaaa agtcgttctt
     6961 tcggaagaaa cggtaaccga acatggaatt atccagattg cggaattcaa taagaatgca
     7021 ggtgcgtgat gcttcttgtg tgagatgctc cagcatttca ccgaaaattt cttcctcctt
     7081 ctctttactt gccggtagag aagtgtccag aaattcacct gcaccatata ccacacattg
     7141 tttgacaaga gaggagggaa gccacttttt ggtcttgcgt atggcggcaa gcaggcgtgc
     7201 tacaggtctg ccttcttctg ttgccactat cagtagcggg gtatatcccg gagtcgattc
     7261 atagatctga aacaactcct tggaatgaaa agtattggtt cccggtaaat caggaatgtc
     7321 ttttccgcga taatatgttg ttagtttaag tggcatccaa atacaaattt acacttttta
     7381 ttcttcattc aacaataaaa aagagaattt gttggcttag cctaaaattt gtctttttat
     7441 cctttgcata tatttgagga aaaaaaggct tggaaaagcg aatttttgta ttattgtcgt
     7501 cctttgtgag tacagaagta aaatggaaac gtctatataa aagattatgc taattgtatt
     7561 ttactaaaca aaggaaaatt aatattaact ttaaattaaa acgaatgaga gagaatgcat
     7621 ttgttgaagc gtggaagaca cagcatagac gcgtttccat gattttaggg ctgactttat
     7681 tgtgtgcccc ttctgccata tctgtttatg cagaaaatgg tgtgaatgat attactgtgc
     7741 aagccgtcat gcagacaaag acagtgaaag gaactgtttt agatgaaaat ggagaaccgt
     7801 tgatcggtgt ttctattgtg gtgaaaggta caagtacagg tacgataact gattttgacg
     7861 gtaagttctc cattaatctt ccggccggaa gtaaagaact ggttgtttct tatatcggat
     7921 ataaagaaca ggctatcatt gtgagcggaa atgccccgct gaatataaag atggttccgg
     7981 atacacaggc tttggatgag gtagtggtca tcggttacgg tacggtaaag aaacgtgatt
     8041 tgacaggtgc ggttgcttct gtgaaatcag aggatatcac catgaatccg ggcgtgaatc
     8101 cgatggatgc gctgcaaggt aaaattgcag gtctggatat cactaattct tcaggtcagg
     8161 caggttcgtc accgacagtt cagttgcgtg gtacccgctc tttacagttg gatgaggatg
     8221 gtaatatctc ttcagatgca tttaagccga cttatattat cgatggtatg ccgggtgata
     8281 ttgctacctt gaatcccaat gatattgaat ctatcgaagt actgaaagat gcatcttcta
     8341 cagctatcta cggttcaagt ggtgcgaatg gtgttattat cgtgactacg aaaggatcca
     8401 agagtggaaa accggtcatc aattttaatg cttatgccgg aacgactatg ggtgcccgag
     8461 ttcctaagat gcgtacgggt gactcataca ttaattatat aaaagattct tataagcctg
     8521 tcggtactac taatgaggag gaaattttcg gtgaaagata cgatgccatc aaaaacaacc
     8581 aatgggtaaa ctggggagat gaagtattac actcaggttt gaagcagaat tatagtattt
     8641 ccgttgccgg aggtactgag aagacgaaag cctatttctc gttgaactat actgatgaga
     8701 agagtatgta tgagaatgat gactataaag tgtactctac ccgtgtccgt atagatcagg
     8761 aaatcaataa atggatgaat gccggtatta atgttcaggc atctttctcc aacaagaatt
     8821 cacgtaatgc cgttttggaa agagcattgt ttgccacccc gttaggtact ccttataatg
     8881 aagacggctc tatcacggaa ttcccgattc caggttcatc atcagacccg aatccgttag
     8941 cagacgaaca ggatggagta tataagaata atactaaagc aggaagggct tatgttgacg
     9001 cttatcttga atggaaaccg gtaaaaggat tgtctgtcaa gtcacagctt ggaggcagtt
     9061 attctcaatc tcgtgccggt aaatttatgg gagaaggctc ctataatgtg ttgaaaggca
     9121 gtacggtggc atatggcgaa gctaccaata agacgggata taattacaaa tgggaaaaca
     9181 tagtaactta tcacaataca tttaataagg atcatgacct gacggttaca ggggttactt
     9241 cctggaatta caatcagagt gaagaatatt atgtctatgg tgaaaacccg gcgaccaatg
     9301 atatgttgtg gtatgcattg cagaatgctg ataataagaa actgaacagc aaatatctga
     9361 tgtcgaaagg gatgggcttt atcggtcgtg tcaactactc atacaaaggt aaatacctgt
     9421 tttctgcttc cagtcgttat gaagcggatt cccgtttgtc gaaagacaat agatggaatt
     9481 tattcccggc agtttctgta ggctggagaa tctcggatga agcatttatg gctggtacaa
     9541 aaagctggtt ggataacttg aaactgcgtg taggctatgg tgttgccgga actactgccg
     9601 gtattgctga atacagttct atggcatctt tggaaaatgt gacaacctct ttgggaggaa
     9661 tgactgttcc gtcagccaag tttacggagt atatcactaa ccgtaatctg acatgggaaa
     9721 agactcatga cttgaatatt ggtattgacg ccagcttcct caataatcgt attgatctga
     9781 cggtggattt gtatcggaca aaaacaacgg atgtaattct ttctcaggca ttgccgacat
     9841 ctattatggg taattacaca ggtagcacta cttataaaat gaacaagaat gctgctgaaa
     9901 cagaaaatcg cggtattgaa cttgctctta atactcgtaa tattgtgaag aaagatttta
     9961 cttggagctc aacagtgaca tttaccgcca acaaagaaaa aattaaatct ttgatcgaag
    10021 ggcaggatat gatgttcaat gcaaaaaagg gtgatatggt gttcaaagtc ggcgaaggag
    10081 tcggttcttt ctatagatat aaagtgttgg gtatctggca atatagcgaa aaggaaactg
    10141 ctgctttgtt cggatgcgaa ccgggcgata ttaagctgga tttacctagt gtgaagaagg
    10201 acggaaatgg ttattattat atgaatcctg aaggagagcg cgttgatatt acggcagaaa
    10261 atccttatgg tgtacgtgcg gattatgatc gtcaggtaat aggtcgtaat actccggact
    10321 ggacattggg ctttaagaat aatttcagat acaaagattt tgatttgtct gtcttccttt
    10381 atgcacgttg ggggcaaatg atgaactatg gtagtgtgat aggtaaatat tcgcctaatc
    10441 cggattacaa tattcctact tattttactt actatgacaa gacgatcgaa gcagatcagg
    10501 atgtcttgtt ctatgctatc gataaatcca aggatagaag tgcttatgaa ggatatgatt
    10561 cgatgtatta tgtggatgga tcattcttta aacttaaaaa cgtaacattg ggttatacgt
    10621 tacccggtaa acttacaaaa cgttttggta tcagtaatct gagagtttat gcgacaatga
    10681 ccaacctgtt tacttattcg ccaaacaaat atgtgaagaa ttacgatccg gaaatgaacg
    10741 gaagcatcaa cttcccattg tctcgtgatt gcatatttgg tcttaattta actttctaaa
    10801 aaatagcaat atgaaaaaga tatatagttt agttctactt gttgccggtg ttttttcttg
    10861 gggctcttgc agtcttgatg aagtgaaccc caacaactcg ggtcagttct ccgatggttc
    10921 ttatacattg gaaacttata aggcattcac caactcgtgc tatacagcct tgatcaacaa
    10981 catctatcag agtagtgact atctggtttg tacggaagcg ggtactgata tttgggaaga
    11041 acctaaatcg ggctccagct atcagcgtta tcatagttat aacggtatga aaaccgatga
    11101 tagctattat tataaagtgt ggcaatattc ttatctgtgt atcaacagct gtaatattgt
    11161 gattgacgga gctgagaatg tgacagggga tgagactgaa attaatgaat gtgtggcaca
    11221 ggccagatgt ctgcgtgctt actattatat gaatctggtg gagcagtttg gaaatgtcga
    11281 tttgcagttg aaggctgccg atagcgagaa tatttctttt gatgctcacc gttctaccgt
    11341 tcccgaaatt tatgctgcca ttatcgaaga cctgaagttt gccgtagaga atctgcctgt
    11401 aagtttcagt gattactata gccgcgttac aaagaaatcg gcgatgggat tattggcacg
    11461 tgcatatatt aatggtgccg gttatgatct gaaagatacc gatggtgtca gctttctgga
    11521 aaaagcctat gatacggcga caaccatgat taataataaa gcgatttatg agtggtatat
    11581 gcatcctgct tttgccgatg tattcaacga aaataataat cgtaacaatg aagaagctct
    11641 gttcattgct gcgggtgccg aaagaaattc ggacgcttac accaatggta actactcaca
    11701 aagtgaaatg ttccgtcact tcttaccttc gttgggaaca tatacggatc tgggtttggt
    11761 agacaagact tcaaacttcg tttacggtcg tccgaacagt aatatcttcc tgccatccaa
    11821 atatctgatg gactgttttg ctgctgatat gaacgactct cgttttcgtt attcatttat
    11881 ttcagcttac tcgtcttatt ctataccggc atggggggcg acttatgaat atggaggttc
    11941 agcgtgtgcc aaagaaatca caagcacact tgctactaaa tttggtattc ccgcatctaa
    12001 tataggtaag aaagtttatc ctcattttaa cttggaatcc aatagtacag ccgatgctaa
    12061 ttactgccag ctggctatct ggaatgcaga tggaacagcg aagactactc aggataaaac
    12121 agatggtaat attcttcatc ctgctatgcc tttagatccg gcagaagctc atcaatatgc
    12181 cgtttattgt tctttgaaga cgctgacaga agaggaaaaa gctcaatatc cggggttggt
    12241 tcttaatgtt ttcgatcttt acgatgagaa tggaacagcc agggctacct atgacaagcc
    12301 tagtgctgcc agtgctttgt ggttatctat ttatccggct ctttctaaat tcaatatgcc
    12361 gggtaataag tttgtcggca gagacgttca gagaaaaact gtggatgtga tgatcatgcg
    12421 tatggcggaa gtttacctga ttgctgctga agcatcggta cgcttgaaca agggagatgc
    12481 tgccaaatat attaatgtac tccgtacgcg tgccggtgcc ggtacggtca gtgagtcgca
    12541 agtggatctg aattatattt tcgatgaata tgcccgtgaa ctttgtggcg aatgtgcccg
    12601 ctggtatttg ctgaaacgta atgctgcttt tgagactcgt ttggctgctt ataataagcg
    12661 tgctgctgag cactttaaga aagaattcta tttgcgtcct attcctacga aatatctgga
    12721 tgcgatcaat aatccggcag aattcggaca aaacgccggt tattaatcag ttaattaata
    12781 atcaagcata attaatagga gccgggcagg agatttttct tgtccggctc tttgtttcca
    12841 tacctgtatc ctgcgtaaaa gtttaaaaag gatttccggt atattttcat tgtttcctga
    12901 tacagctttt tattattttc tttatttttg tgtgtccaaa caaaatagcg ctatgataga
    12961 agaaatgctt gcttataaca gagagttcgt taagaacgag ggatataaag aatatataac
    13021 gaataagtat cccgataaaa agattgctat cttatcctgt atggatacac gtctgacagc
    13081 tttactcccg gccgcactag gcattaagaa cggagacgtt aaaatgatca agaatgcagg
    13141 aggcgtcatt tcccatcctt tcggtagtgt gattcgcagt ctgcttgtcg ctatcttcga
    13201 gttaggtgtg gaggaaataa tggtgattgc ccattctgat tgtggagcct gccatatgca
    13261 cagtgaagaa atgcttgaga agatgaaggc acggggtatt aatgccgatt atattcatat
    13321 gatgagtttt tgtggagtcg attttcattc ttggctagat ggctttgaag atacggagaa
    13381 gtcggtaagg ggaacggtcg attttatagt tcatcatcct ttgattccgt cggacgtgaa
    13441 agtgcacggg tttatcatag actccactac tggagaactg acgcgaattg tataggaaat
    13501 cgccctttct gcctatcagg aactgcataa aacatggtgt cactatcgca acaggatagt
    13561 gtcactatca ctgtctcatg gtgtcactat gtcattggga taccgacact atcccaaatg
    13621 aaaaaaataa ggcagctttt tatcggctgc ctttatcttt ctgcggttat atactttctt
    13681 tgactcatgc actcgtttgt aacaaacggg gtgtccgtgc tctttgattt ctgcctcacg
    13741 gctggcttta cgattcgctt tgatgtaatc gtcttgtgta attcgttttt tcataatgaa
    13801 tatatttcaa aagcaaagtt actacaaaaa agtgaaatgc ggaaagatat agtgatagaa
    13861 ttgagt
//
