LOCUS       c00437_gnlPro..        15102 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AEPLFIFD_437.
ACCESSION   c00437_gnlPro..
VERSION     c00437_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 21:18:57
            Original ID  :: gnl|Prokka|AEPLFIFD_437
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15102
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15102
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[245:5102]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      246..5102
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..15102
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15102
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             complement(3..242)
                     /locus_tag="ctg437_1"
                     /transl_table=11
                     /translation="MDCKIDIIPRVLHFKQPAGTSRGTYTTRKVWYLHFTAPEFPNWVG
                     IGECAPLPNLSCDDLPDYEEVLAKICRQVENQGGK"
     CDS             complement(246..1070)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg437_2"
                     /sec_met_domain="ECH_1 (E-value: 2.4e-82, bitscore: 265.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTQREWTTIREYEDILFDYYNGIARITINRERYRNAFTPTTTAE
                     MSDALRICREEADIDVIVITGAGDKAFCSGGDQNVKGRGGYIGKDGVPRLSVLDVQKQI
                     RSIPKPVIAAVNGFAIGGGHVLHVVCDLSIASENAIFGQTGPRVGSFDAGFGASYLARV
                     VGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLEQLEDEYVQWAEEMMLLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATLLYYLTDEAQEGKNAFLEKRKPNFKKYPKFP"
     CDS             complement(1074..2741)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg437_3"
                     /sec_met_domain="TPP_enzyme_C (E-value: 6.8e-09, bitscore:
                     25.6, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSDKKNILQLVALLEAHGITKVVLCPGSRNAPIVHTLSTHPGFT
                     CYAMTDERSAGYFAIGLALNGGHPAAVCCTSGTALLNLHPAVAEAYYQNIPLVVISADR
                     PAAWIGQMAGQTLPQPGVFQTLVKKSVNLPEIQTEEDEWYCNRLVNEALLETNHHGKGP
                     VHINIPISEPLFQFTVESLPEVRVITRYQGLNVYDRDYNDLIERLNRYQKRMIIVGQMN
                     LIYLFEKRHTKLLYKHFVWLTEHIGNQTVPGIPVKNFDAALYAMPEEKTGQMTPELLIT
                     YGGHVVSKRLKKYLRQHPPKEHWHVSADGEVVDLYGSLTTVIEMDPFEFLEKIAPLLDN
                     RVPEYPRVWENYCKTIPEPEFGYSEMSAIGALIKALPESCALHLANSSVIRYAQLYQVP
                     STIEVCCNRGTSGIEGSLSTAVGYAAGSDKLNFIVIGDLSFFYDMNALWNINVRPNLRI
                     LLLNNGGGEIFHTLPGLDMSGTSHKYITAVHKTSAKGWAEERGFLYQRVENEEQLAEAM
                     KTFTQPEAMEQPVLMEVFSNKNKDARILKDYYHQLKQK"
     CDS             complement(2761..3873)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg437_4"
                     /sec_met_domain="Chorismate_bind (E-value: 3.7e-58,
                     bitscore: 186.9, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDENSNLTTIDALIQRKQPFAVYRVPGEKYPRLLTEDVGAVRLI
                     FDLKELNGQRGFVIAPFRIDKSCPIVLIQSDRTGQPLPMEIVAEEEQDLQSYPEESFHT
                     LCTGKYATCFHTFIEALRDATFDKLVLSRSLTIGKNPEFSPSAVFRAACQRYIHSYIYL
                     CYTPQTGVWLGSTPEIILSGEKNEWNTVALAGTQPLQNGKLPQVWDDKNRQEQDYVASY
                     IRRQLLSLGIRSTESGPYPAYAGALSHLKTDFHFSLKDNKNLGDLLKVLHPTPAVCGLP
                     KEEAYRFILENEGYDRKYYSGFIGWLDPEGRTDLYVNLRCMHIEDEQLTLYAGGGLLAS
                     SELNDEWQETEKKLQTMRRILVSAPIMMNH"
     CDS             complement(3870..5102)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg437_5"
                     /sec_met_domain="HBT (E-value: 2.5e-17, bitscore: 53.0,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKLLVLDVDGTLLNDAKEISKRTLAALLKVQQMGVRIVLASGR
                     PTYGLMPLAKSLELGNYGGYILSYNGCQIINAQNGEILFERRINPEMLPYLEKKARKNN
                     FALFTYHDDTIITDTPENEHIQNEARLNNLKVIKEEEFSVAIDFAPCKCMLVSDDEEAL
                     VSLEGHWKRRLNGALDVFRSEPYFLEVVPCAIDKANTLGALLEELDVKREEVIAIGDGV
                     CDVTMIQLAGLGVAMGHSQDSVKVCADYVTASNEEDGVALAVEKAIIAEVRAAEIPLDQ
                     LNAQARHALMGNLGIQYTYADEDRVEATMPVDHRTRQPFGILHGGATLALGETVAGLGS
                     MILCQPDEIVVGMQVSGNHISSAHEGDTVRAVATIVHKGRSSHVWNVDVFTSTNKLVSS
                     IRVVNSVMKKR"
     CDS             complement(5187..5549)
                     /locus_tag="ctg437_6"
                     /transl_table=11
                     /translation="MVQVRIKRVYEDFSETDGYRVLVDKLWPRGIKKEWLKYDYWAKDI
                     TPSAALRRWFHEDIPGHWNDFVVMYQKELEASQAVADFLTLIKPHPVITLLYASKEPVY
                     NHARILRDYLEMHLKE"
     CDS             complement(5620..7389)
                     /locus_tag="ctg437_7"
                     /transl_table=11
                     /translation="MKSIRSVICFCLFLFVFNQLLFADKTIENDSLYTSEYISRIYMAE
                     PERALSLLDGAESKKTIPLRIIHELRSRVYRNMYMTKLAFLYAKKSYLLDSVSQKDTKH
                     LLTMTVDLAELAVLMSDHKESMRYALDGIKLAQKEKDKGAESKLLFCIGENKWQLSFKE
                     EAYDYFDKAIKLLQGTSSKLEMAMLSYFYGMKMDYLLNDSRSKEALEVGLKREKLLKDI
                     AKLPEKTKGFLDLQYTYLYAKMSYICYLEGKYDQAEKYYQQYLSTENSQTPDGKTYAIP
                     YLLVSKQYQKVVDQCQDFKKLMQEQDTVNLQYISILQKEVKAYKGLKDFEKVAALRESI
                     ISIIDGINSKDKQNAALELNAIHKADEQEEYIAEQTLQLRIRNISLAFLGCVTCLILFV
                     LWRIWRHTIIVKYKNKMLAKFINEKLAGKVENKQLFIDGDAEDPIAVPLDLEPETGFSE
                     KDDLSPDEVVESREEEDENKKIFKELNRIVVQDQLYLSPELSREDLAQIVHLNNARFAR
                     MIKENTGTNFNGYINELRINYAIQLLKQHPNYTIRAIADEAGFNSTPILYSMFKKKTGM
                     TPYEFKKTQESLG"
     CDS             complement(7768..8535)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acetyltransf_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg437_8"
                     /sec_met_domain="Acetyltransf_1 (E-value: 4.1e-08,
                     bitscore: 23.4, seeds: 223, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEAKYITLTKENIEKEHICCAFSDKKCKDSYELKKTWLKNEFENG
                     YVFRRLDERAKVFIEYGPAEKAWVPVNAPNYLMINCFWVSGKYKGCGHGKALLQSAVED
                     AKAQGRDGLVTVVGTSKFHFMGDAKWLLRQGFETIEKLPYGFSLLALKINPAAPDPSFN
                     GTVSSGECEEKEGVVVYYTHRCPFAEFHVRNSLVSVTENKGIPLKIVRLETMAQAQNAP
                     TPATIFSLFYKGKFVTTDLSACMEQRFDKALGL"
     CDS             complement(8872..10122)
                     /locus_tag="ctg437_9"
                     /transl_table=11
                     /translation="MKKNIRYNIVLLLLMVEAVLIPTFAQMPEIKQGQSISFEEYLNRV
                     GKKNLSYLAEKLNVSIADAEVIARKIFPDPELEFEAGNETFSLGVSYSLEMGNKRGARI
                     KLARTQAELEKLFLQQGFQDLRAEAADLFLEAILQRELLEVQKSSYEYMYQLSQSDSLR
                     YVSGEITENDVRQSKLETVTLLNTVYSQEAAYHSALVLLNKHMGMSADTLHIPLGNWEE
                     LSRDFALSDLVKAGLDNRIDLLVAQKSTEVTTREYKLTRAERRPDIGVSVSYERNWNGF
                     LPPSRSATAGVSVPLTFSNINKGAVKAAKFRIAQSEIMERDMELQIQTEITQAWFNYEA
                     EKKKIAQYKAGVLEDSQKVLDGMVYKYKRGETSILDVLVAQRTYNEVQQEYLETMKGYA
                     ASLVALERACGIWDICF"
     CDS             complement(10100..13207)
                     /locus_tag="ctg437_10"
                     /transl_table=11
                     /translation="MKKELMLSIIQKRWVMLCLFVMMCIFGYYSWKQLSIEAYPDIADV
                     TSQVVTQVPGLAAEEVEQQITIPLERAINGLPGMHVMRSKSTFGLSMITIVFKDGTEDY
                     WSRQRVQERLNEVELPYGAVPGLDPLTSPVGEVYRYIIESDQHSLRELTDLQNWVIIPR
                     IKEVSGVADVTNFGGITTQFQVEVDPSKLEQYNLSLSQVVEAIENNNANVGGSVLNRGD
                     LGYVVRGIGLIGNLDDLGHIVVSTTSGVPVFLNDIGSLKYGNLERKGVLGYTDRTRNYS
                     ESLEGIVLLLKHENPSKVLEDIHVAVDELNNETLPEGVRIHTFLDRTNLVDTTLSTVSH
                     TLLMGMALVVLVLILFLGNWRGALLVSITIPVSLLIAFILMHLTDIPANLLSLGAIDFG
                     IIVDGAIVMLETILKKREDNPKQYLEEKSMAQRAKEVGRPILFSTIVIITAYLPLFAFE
                     RVERKLFTPMAFTMSYAMIGALLVALLLIPGLAYAIYRKPHKIYKNKWLDRLKDKYIRT
                     ITGFLEAPLKAIIPSGLILTAGIVLSVVVGKDFLPELDEGSIWLQVNLPPGISVEKSRE
                     LSDTLRARTMKYSEVTYIMVQAGRNDDGTDPFTPSHFEVSIGIKPYDEWPKGKTKKDLI
                     HELEEEYKLLPGFKVGFSQPMIDGVMDKIAGAHSELVVKVYGEDFRETRRIAEEITRAL
                     GTVRGAVDLDIDQEPPLPQLQISMNRDAIARYGLNVSDVADLIEVAVGGKAIAQLYQGD
                     RQYGITCKYKEEARNTPEKIAGLMLTSSTGAKIPLSQVADVRLSVGESTITREMNRRHL
                     TVKLNLRGRDLTSFLNEAQNTINEKVHYDKNKYTIKWGGAFENQKRAYTRLAVIIPLTL
                     TGMFILLYVTFGKFRQAGLVLAIVPLALFGGMLALNVRGMTLNVSSAVGFIAMFGLSIQ
                     NGIIMVSQVNGLRRGGMELRKSVIEGARQRFRPILMTSVTTILGLFPASLATGIGSDVQ
                     RPLATVIVYGLMFSTLISMFLLPAFYYLVENNVLNKKKNDEKEYTI"
     CDS             complement(13214..14323)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Biotin_lipoyl_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg437_11"
                     /sec_met_domain="Biotin_lipoyl_2 (E-value: 7.1e-10,
                     bitscore: 28.6, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMMKRELHTFIIGSVLFFTACGDKQESEQKSGYRIQGDTVYIADP
                     LLLEKIKVSVSELKPYSKKVITSGVVRPIPPRYAYVAPPFAGRVTKSYVRIGQSVRQGT
                     PLFEISSPDFTSAQKEYFQALSSRELAKKDLKRKEDLIRNGVSSQRELEEAQNALLIAD
                     KEFENASAALRVYQVDNPVEMILGQPMIVRSPIPGEVIKDNIVTGQYLKDDTEPIAIVA
                     DLSKVWIAAQVKEKDIRFINEGSSLDIEISALPGTVIKGNVYHVEEEVDEETRSIQVLS
                     VCDNLNGHLKLGMYTTVHFLSVPVGQIQIPEKALLQGEKDSYVFVQIAPLVFVRTSVTV
                     ETTENGIAVISEGLRPGDKIISEGGYYLK"
ORIGIN
        1 agcttacctc cctgattctc tacctgccgg cagattttag ccagcacttc ctcgtaatcg
       61 ggaagatcat cacagctaag atttggcaga ggagcgcact ccccgatccc tacccaattg
      121 ggaaattcgg gagcagtaaa atgaagatac cagacttttc gcgttgtgta tgtgcctcgt
      181 gaagttccgg ccggctgctt gaaatgaagc acccgcggaa taatgtctat tttgcaatcc
      241 attgtttaag ggaacttcgg atatttctta aagttaggtt tacgtttctc cagaaatgca
      301 ttctttcctt cctgagcctc atccgtcaga tagtaaagca aggtcgcatc ccctgccagc
      361 tcctgaatac ctgcctggcc gtccagttcg gcattcaatc cggctttaat catccgcaag
      421 gccaacggac tgagcagcat catttcttcc gcccattgca catactcatc ctccagttgc
      481 tccaatggaa ctactttatt caccaatccc atatccaacg cttcctgcgc attgtatttc
      541 cggcaaagga accatatctc acgtgccttc ttctgaccga cgacacgagc cagataagag
      601 gctccgaaac ctgcatcaaa gctacctacg cgaggaccgg tctgtccgaa gatcgcattc
      661 tccgaagcaa tcgataaatc gcaaactaca tgaagcacgt gtccgccacc aatggcaaat
      721 ccatttacgg cagcaattac cggtttcgga atgctgcgga tttgtttctg tacatccaga
      781 acactcagac ggggaacacc gtccttgccg atatagccgc cacgcccttt cacattctgg
      841 tcaccgcccg aacagaaagc cttgtcacca gctcccgtaa tcacgatcac atcaatatcc
      901 gcttcttccc ggcaaatgcg caatgcgtca ctcatttcag ccgttgtagt cggagtaaat
      961 gcatttcgat agcgttcacg gttaatggtg atgcgggcaa tcccattata gtaatcaaag
     1021 aggatatctt cgtattctct gatggttgtc cattctcttt gtgttgacat aatctatttt
     1081 tgttttagtt gatgataata atctttcagt atacgtgcat ctttattttt attgctgaat
     1141 acttccatca gaaccggttg ttccatggct tccggttgtg tgaaggtttt catcgcttcg
     1201 gcaagctgtt cttcattctc tacccgttga taaaggaatc cgcgttcttc cgcccatcct
     1261 ttggcagatg tcttgtgaac ggctgtaata tacttgtgcg atgtacccga catatccagt
     1321 ccgggtaatg tatggaaaat ctcccctcct ccgttattca gcaaaagaat gcgtagattg
     1381 ggacggacat tgatgttcca caaagcattc atatcataaa agaaactaag gtcacctata
     1441 actataaaat ttagtttatc cgaaccggcg gcatatccca ctgccgtgga caacgagcct
     1501 tcgatgccgc ttgtaccccg attacagcat acctcaatcg tagaaggaac ctggtataac
     1561 tgagcatagc ggataacaga actatttgcc agatgcaatg cacatgattc cggcaatgct
     1621 tttatcaaag caccgatagc cgacatttcc gaatatccga actccggttc gggaatggtc
     1681 ttgcaataat tctcccatac acggggatac tccggcacgc ggttatccag caatggagct
     1741 attttctcca gaaactcaaa cgggtccatt tcgatgacgg tagtcagaga accgtaaagg
     1801 tcaaccactt ctccatcagc agacacatgc caatgttctt taggcggatg ctgccgaaga
     1861 tattttttca accgcttgga aaccacatgt ccgccataag taatcaataa ctcgggagtc
     1921 atctggccgg ttttctcttc gggcatcgca taaagcgccg catcaaaatt cttcactgga
     1981 ataccgggta ctgtctgatt accgatatgc tcggtcagcc acacgaaatg tttatataac
     2041 aatttggtat gccgtttctc aaacaagtaa atcaagttca tctgtccgac aataatcatc
     2101 cgcttctgat atctgttcaa gcgttcgatc aggtcattgt aatcccggtc gtatacattc
     2161 agcccctgat agcgcgtaat gacacgtact tcgggaagcg actccaccgt aaactggaac
     2221 aaaggttcgg atataggaat attaatatgt accggacctt ttccatgatg gttggtttcc
     2281 agcaaggctt cattcaccaa gcggttacag taccattcat cctcttctgt ctgaatctcc
     2341 ggaaggttta ccgacttctt caccaatgtc tgaaaaacac cgggctgcgg caatgtctgt
     2401 cccgccatct gtccaatcca ggcagcaggc cgatcggcag agataacaac taaaggtata
     2461 ttctgataat acgcttctgc cacagcagga tgaagattga gcaacgctgt accggaagta
     2521 cagcaaacgg cagcaggatg cccgccattc agcgcaagac caatcgcaaa ataaccggca
     2581 ctccgttcat ccgtcatagc ataacaagta aaacccggat gagtagacag cgtatgcaca
     2641 ataggtgcat tacggctacc gggacataac actactttcg taattccatg cgcctcaagc
     2701 agcgcgacca actggagtat atttttcttg tccgaataca tattgatagt gattagcttg
     2761 ttagtgattc atcattattg gagcagacac aagaatacgc ctcatggtct gcaatttctt
     2821 ttccgtttcc tgccattcat cattcaactc tgaagaggct aacaatccgc caccggcata
     2881 cagtgtcaat tgctcgtctt caatgtgcat gcaacgcaga ttcacataca aatctgtgcg
     2941 tccctccgga tcgagccaac cgataaaacc ggaataatac ttacgatcgt acccttcatt
     3001 ttccaaaatg aaccggtagg cttcttcttt aggcagtccg cacacggcag gagtcggatg
     3061 caggactttc agaaggtctc ccagattttt attatctttc aaagagaaat ggaaatcagt
     3121 tttcagatgt gacaaggcac cggcataagc cggataaggt ccgctctctg tggagcgaat
     3181 gcccagcgaa agaagctgcc gacggatata ggacgccaca taatcctgct cctgacggtt
     3241 tttgtcatcc catacttgcg gaagtttacc attctgcaaa ggttgagttc ctgccagggc
     3301 aactgtgttc cattcatttt tttcgcccga caatataatt tcgggggtac ttcccagcca
     3361 cacgcccgtc tgaggagtat aacacagata gatataggaa tgaatataac gttgacaagc
     3421 tgcacgaaaa acagctgaag gggaaaactc cggattcttt ccaatagtga gactacggga
     3481 aagcaccagt ttatcaaagg tagcatcacg caaggcttca ataaatgtat gaaaacaggt
     3541 cgcatacttc ccagtacaaa gggtatgaaa agattcctcc ggataacttt gcaagtcctg
     3601 ctcttcctct gccacgattt ccataggcaa cggttgtcca gtcctgtcgg actgtatcaa
     3661 cacaatcgga catgacttat ctatacggaa cggagcaatc acaaatcctc tttgtccatt
     3721 cagttctttc aaatcgaaaa tcaagcggac agctccgaca tcttctgtca acagacgagg
     3781 atacttctcc ccgggaacac gataaacagc aaagggctgt ttccgctgaa taagtgcatc
     3841 aatagttgtc aagttactat tttcgtcaat catctttttt tcatcacact gttgaccacc
     3901 cgtatagagg acaccagttt attggttgaa gtaaaaacgt ccacattcca tacatgggag
     3961 gaacgtcctt tgtgtacaat cgtcgctact gcacgtactg tatcaccttc gtgcgcagaa
     4021 gatatatgat ttccgctgac ctgcattcct accacaattt catccggctg acagagaatc
     4081 atcgagccga gtccggcaac tgtttctccc aatgcaagcg tagctccacc gtgcaaaata
     4141 ccgaacggct gacgggtacg gtgatctacc ggcatcgtcg cctctacacg gtcttcgtcg
     4201 gcatatgtat attggatacc cagattaccc atcaatgcgt gacgcgcctg tgcattcaac
     4261 tggtccaaag gaatctctgc agcgcgaact tccgctatta tcgccttttc gacagccaga
     4321 gccactccgt cttcctcatt ggaagctgtc acataatccg cacagacctt taccgaatcc
     4381 tgcgaatgcc ccatcgccac tcccagtcct gccagctgaa tcatcgttac atcgcacaca
     4441 ccgtctccta tagcgatgac ttcttcacgc ttcacatcca gttcttccaa taaagctccc
     4501 aatgtgttgg ctttatcaat cgcacacggc actacttcca gaaaataagg ttcggaacgg
     4561 aaaacatcca aagctccgtt caaccgtctc ttccagtgtc cttccagact aaccaacgct
     4621 tcctcgtcat cgctgacaag catacactta cacggagcaa agtcaattgc tacagaaaat
     4681 tcctcttcct tgatcacttt caaattattc aagcgagctt cattctggat atgttcattc
     4741 tccggagtgt cagtaatgat cgtatcatca tggtaagtga acagtgcgaa attatttttt
     4801 cttgccttct tttccagata aggcaacatt tccggattaa tcctccgctc aaacagtatt
     4861 tctccgtttt gagcattaat tatctggcaa ccattataag aaaggatata acctccataa
     4921 tttccgagtt ctagggattt ggctaaaggc atcagaccgt aagtcggtcg gccggatgcc
     4981 aacacgatac gtactcccat ctgctgaact ttcagcaaag cagccaatgt acgtttacta
     5041 atttcttttg catcattgag aagcgttccg tctacatcaa gaactaataa tttatacttc
     5101 atggacacac gattttgatt tagattacaa aggtaggaaa ttgagtgaac gactgaaagc
     5161 ggaaagagat aaaaattact ttaatttcac tctttcagat gcatttccaa ataatcacga
     5221 aggattcggg catgattata aaccggttct ttggatgcat aaagcaaagt gatcaccgga
     5281 tgaggtttga taagagtcag aaaatcggca acagcttgag aagcttccag ttccttctga
     5341 tacattacga caaaatcatt ccagtgaccc ggaatatctt catgaaacca tctgcgcagt
     5401 gctgcggaag gcgttatatc ttttgcccag taatcatatt tcaaccattc ttttttgatt
     5461 ccacgtggcc agagtttatc taccagcacc cgatatccgt cggtctctga aaagtcttcg
     5521 tacactcgct ttatcctaac ttgcaccatt tccgtttata tttagttatc ataagaataa
     5581 accgataaaa cggaaaattg tttatcgaaa aagccaaaat caacctaagg attcctgcgt
     5641 ttttttaaat tcgtaaggag tcataccagt ctttttcttg aacatactgt acagaatagg
     5701 cgtactatta aatccggctt catcagctat cgcacgaatg gtataattgg gatgttgctt
     5761 caataactga atcgcatagt taatacgaag ttcattaata tacccgttga aattagttcc
     5821 ggtgttttcc ttgatcatcc gggcgaaacg cgcattattc aaatgtacaa tctgagccag
     5881 atcctctctc gacaattccg gagacagata taactgatcc tgaacaacaa tacgattcag
     5941 ttctttgaaa attttcttat tctcatcctc ttcctcccta ctctccacta cttcatccgg
     6001 agataaatcg tctttttcgg aaaagccagt ttccggttcc aagtccaatg gaacagctat
     6061 cggatcttcc gcatctccat ctatgaataa ttgtttgttc tctacttttc cagccagttt
     6121 ctcattgata aactttgcca gcattttgtt tttatattta acaataatcg tatgacgcca
     6181 aatccgccat agcacaaata aaatgagaca agtgacacat cccaaaaaag caagtgatat
     6241 gtttctgatt cttaactgta aagtctgttc ggcaatatat tcttcctgct cgtcagcttt
     6301 atgaatagca tttaattcca aagccgcatt ctgtttatcc ttgctgttaa taccatcaat
     6361 aatagaaata atagactcac gtaatgctgc tactttttca aaatccttca agcctttata
     6421 agctttcacc tctttctgaa ggatactaat atactgcaag ttgacagtat cctgctcttg
     6481 catcaatttc ttaaaatcct gacattgatc aacgactttc tgatattgtt tagacactag
     6541 cagataaggt atcgcatagg tttttccatc cggtgtctgt gaattctctg ttgacaaata
     6601 ttgttgataa tatttttccg cctgatcata ctttccttcc agatagcaga tatacgacat
     6661 ttttgcatac aagtaagtat attgcagatc aagaaagcct tttgtttttt ccggtaattt
     6721 agctatatct ttaagtagct tttcgcgctt caacccaacc tccaatgctt ctttactacg
     6781 ggaatcattg agcagataat ccattttcat cccataaaag tatgaaagca tagccatttc
     6841 caatttggaa cttgtacctt gaagcaattt gatagctttg tcaaaatagt catatgcctc
     6901 ctctttgaaa gacaattgcc atttattttc accaatgcaa aacaacagct tactttcagc
     6961 ccctttatcc ttttcttttt gtgctagctt gataccatca agagcatacc tcatactctc
     7021 tttatggtca ctcataagca ctgctaattc tgccaggtcg acagtcatgg tcaacaagtg
     7081 cttagtatct ttctgagaaa cggaatccag caaataagac tttttggcat acaaaaaagc
     7141 cagtttagtc atatacatat tacgataaac cctgctgcgt aattcatgta taatacgcag
     7201 agggatagtc ttcttacttt cagctccatc caacaaactt aaagcccgtt caggttctgc
     7261 catataaatt cgacttatat actcactggt atatagcgaa tcattctcta tagttttgtc
     7321 ggcgaaaagg agctggttaa acacaaacaa aaacaaacaa aaacaaataa ccgagcgaat
     7381 acttttcatt ataatcccaa tgattttact ccccaaaagt aaaacatagt ttcataaaat
     7441 gcaagaattg aacatatttg aatgaactaa aataagaaaa gttagtgatt ataaaagtca
     7501 ggagctatca agttttcccc accaaccaca tacaataaaa tactaaaaat caagcatatg
     7561 tcacatacat aaaacaaaac atctcaacat ataaataaac tgccgattct attaatgaat
     7621 ctgcataaga tcagagcagc acatgaaaaa tcgaaccgac cagtctaaat aaacaccaga
     7681 caattattaa cccgccacac tcatcagagc aaaacagcac aaaaacagaa aatcaaaaaa
     7741 gagaaacaca tactgtaata agaaagatta taatcccaac gctttatcaa accgttgctc
     7801 catacatgca ctcaaatccg tcgttacaaa ctttccttta tagaaaagag aaaagatagt
     7861 agcaggtgta ggtgcatttt gtgcttgtgc catcgtttcc aatctgacta tcttcaatgg
     7921 aatacctttg ttctcagtca cactcactaa agaattacgg acatgaaact ctgcaaacgg
     7981 acaacgatgt gtataataaa cgactacacc ttctttttcc tcacattctc cacttgatac
     8041 tgttccattg aatgacggat caggagctgc cggatttatc ttcaaagcca aaagactgaa
     8101 accatagggt agtttttcta tcgtctcaaa cccctgacgt aataaccatt tcgcatcacc
     8161 cataaaatga aatttagagg taccgaccac agtcaccaag ccatccctac cctgtgcttt
     8221 ggcatcctcg acagcagact gcaatagtgc tttgccatgc ccgcatcctt tatattttcc
     8281 tgaaacccaa aaacagttta tcattaaata gttaggtgca ttaaccggaa cccaagcttt
     8341 ttcggcaggt ccatattcta taaatacttt tgcacgttcg tcaagccgtc tgaaaacata
     8401 gccattctca aactcatttt tcagccatgt ctttttcaac tcatagctat ccttacattt
     8461 cttatcggag aaagcacagc aaatatgttc tttttcgata ttctctttag tcagagtgat
     8521 atacttcgct tccataatat tctgtttatt agtatataaa ttccggttgt ccatttcaac
     8581 tacagcaaag atacacaatc gaaagtaata aaacattgtc cagtctcgtc aaaatgacac
     8641 agtagtacgg attaaagttc ggaaaacaga taagtaaata aacctgagtg acaaacttat
     8701 caaagaactt attgaccact ctgtggaaga agtgatcaaa aaaactccct aagaaaaaac
     8761 aggaggaata tcgcacaatg atttaacata aagcgtgaaa ccgctgactg gtaaccatac
     8821 aaatatccgg ctttgctgca attcacaata gtaaagccgg atatttaact gtcaaaagca
     8881 tatatcccat ataccacaag ctctttccaa tgctactagt gaagcggcat atcctttcat
     8941 tgtttccaga tactcctgtt gcacttcatt ataagtacgc tgggcaacca gtacatcaag
     9001 aatactcgtt tctccccgtt tgtatttata taccattccg tcgagcacct tctgcgagtc
     9061 ttcaagtaca ccggctttat attgagctat ctttttcttt tcagcctcat agttgaacca
     9121 ggcctgggtt atctctgtct gtatctgcaa ttccatatct ctttccatta tctccgattg
     9181 ggcaatccga aactttgcag cttttacagc tcctttattt atattcgaga atgtcagagg
     9241 aacagataca ccggcagtag cagaacggga cggaggaaga aagccgttcc agtttctttc
     9301 ataagaaaca gatactccga tatcgggtct gcgttccgct ctcgtcagtt tatattcccg
     9361 ggtagtaact tcagtacttt tttgagcaac aagcaggtcg atgcgattat ccagtcccgc
     9421 tttgaccaaa tcagacagag caaagtccct gcttagctct tcccaatttc ccaaagggat
     9481 atgaagcgta tcagcactca tccccatgtg tttattcaac aaaaccaaag cggaatgata
     9541 agccgcctcc tgactgtaaa cagtattaag caaggtgaca gtttccagtt ttgactgccg
     9601 gacatcattc tccgtaatct ctcccgaaac ataacgtaaa ctatctgact gactcagctg
     9661 atacatatac tcataagaac ttttctgtac ttcaagtaat tcgcgctgaa gaattgcttc
     9721 tagaaaaagg tcggcagcct ccgccctcaa atcctgaaag ccctgttgca ggaacagttt
     9781 ctccaattct gcctgagtcc gcgccaactt aatacgtgct ccccttttat ttcccatttc
     9841 taatgaatag gaaactccca acgagaaagt ctcattacct gcttcaaatt ccaactccgg
     9901 atccggaaag attttccggg caattacttc cgcatcagca atactcacat tgagtttttc
     9961 ggctaaataa ctcaggttct ttttccctac ccgattcaga tattcttcga aagaaataga
    10021 ctgcccctgc tttatttcag gcatttgcgc aaaagtcgga atgagtacgg cttccaccat
    10081 taaaagcaag agcactatat tatatcgtat attctttttc atcgttcttc tttttattta
    10141 aaacattgtt ctcaaccaga taatagaaag ccggaagcag aaacatagag ataagggttg
    10201 aaaacatcaa tccatacaca atcactgttg ccagcggacg ctgtacgtca ctaccaattc
    10261 cggttgccaa cgaagccggg aaaagtccga gtatcgtagt gaccgaagtc atcagaatag
    10321 gtcggaaacg ctggcgtgcc ccttctatga ccgatttccg gagttccatt cctcccctgc
    10381 gcagcccatt gacctgcgat accatgataa ttccattttg tatggaaagc ccgaacatcg
    10441 ctataaatcc tacggcagaa gatacattca gcgtcatacc acgcacatta agagcaagca
    10501 tacctccgaa aagtgccaga ggaacaatag ccaataccag tcctgcctgc cggaacttcc
    10561 cgaacgtgac ataaagcagt ataaacatcc ctgtcagtgt cagcggtata atgacagcaa
    10621 gacgtgtata agcccgtttt tgattttcga aggcccctcc ccatttgatg gtatatttat
    10681 tcttgtcata atgtactttc tcattgatcg tattctgggc ttcattcaga aaagatgtca
    10741 ggtcacgacc gcgcaaattc agctttaccg tcaaatggcg tctgttcatt tccctggtaa
    10801 tcgtactttc gccgacactc aatctgacat cggcaacctg agaaagaggt atctttgcac
    10861 cggtggaaga agtcaacata agtccggcta ttttctccgg agtattccgc gcttcctctt
    10921 tatacttaca ggtgatgcca tactggcggt caccctgata aagttgtgcg atagctttac
    10981 ctccgacagc cacttcaatc agatccgcta catcggatac atttaatccg taacgagcta
    11041 tggcatcacg attcatactg atctgtaact gtggcaaggg tggttcctga tcaatatcca
    11101 gatcaacagc ccctcgcaca gttcctaatg ccctggttat ttcttcggca atacgacgtg
    11161 tttcacgaaa atcttcgcca tatactttca ccaccagttc actatgggcc ccggctatct
    11221 tatccatcac cccgtctatc ataggttggc taaatcctac tttaaaaccg ggaagtaact
    11281 tatattcttc ttccagttca tgaatcaaat cctttttagt ttttcctttc ggccattcat
    11341 cataaggctt aataccgatg gacacttcaa aatgtgaagg ggtgaacgga tcagttccgt
    11401 cgtcattcct tcccgcctgt accataatat aagttacttc ggaatacttc atcgtacggg
    11461 cacgcaaagt atcagataac tcccgtgact tttctacgga aattccgggt ggcagattaa
    11521 cctgtaacca tatcgaacct tcatccagct ccggaaggaa gtcttttcct acgacaacac
    11581 tcaacacgat ccccgctgtc agaatcagtc ctgatggaat gatggctttt aagggagctt
    11641 ccagaaatcc tgtaatggta cgaatgtatt tatcctttag tctgtccagc catttattct
    11701 tatatatttt atgtggttta cgatagattg cataggcaag tcccggaatc aataagagcg
    11761 caaccaacag tgctccaatc attgcatagc tcatcgtaaa tgccattgga gtaaaaagtt
    11821 tgcgttcaac acgttcaaag gcaaacagcg gaaggtatgc cgtaataatg acaatggttg
    11881 agaaaagaat aggccgaccc acttctttgg cgcgttgcgc catgcttttt tcttcgagat
    11941 attgtttggg attatcctca cgtttcttaa ggatcgtttc cagcataacg atagcgccgt
    12001 ccacaataat accgaaatca atagcaccaa gcgacagaag gttagccgga atatccgtca
    12061 gatgcataag aataaaagcg ataagcaatg acacaggaat cgttatagat accaataatg
    12121 caccacgcca gttgcctaga aacagaataa gcacaagaac caccaaagcc atacccatca
    12181 gcaaggtatg ggatacggta ctcaaagtag tatccaccaa gttggtacga tccagaaaag
    12241 tatgtatcct cactccttcc ggcaatgtct cattatttaa ctcatcaact gccacatgaa
    12301 tatcttccag tactttagac ggattctcat gtttcagaag gagtacaatt ccttccagac
    12361 tctcagagta gttgcgggta cggtccgtat atcccagcac tccctttctt tcaagatttc
    12421 catacttcaa agaacctata tcattcagaa agacaggaac tccggaagta gtactcacta
    12481 caatatgtcc caaatcgtcc aaatttccga ttaatccaat tccccgtacc acataaccca
    12541 agtcaccacg attcaacacg cttcccccca cattggcatt gttattctca atggcttcaa
    12601 caacctggct gagagataaa ttatattgtt ccagtttgga cggatctact tcaacctgga
    12661 actgagtagt gatcccaccg aaattggtta catcagccac tcccgacact tccttgatac
    12721 ggggaataat tacccagttc tgaaggtcgg ttaattcgcg taatgagtgc tggtcacttt
    12781 ctatgatata acggtacact tctcctacgg gagatgtcag cggatcaagt cccggaacag
    12841 ctccataagg cagttctact tcattcaatc tttcctgtac gcgctggcgg ctccagtagt
    12901 cctctgtccc gtccttaaag acaatggtaa tcattgacag cccgaatgta ctcttactcc
    12961 gcatgacgtg cataccgggc agcccattaa tagcgcgttc caaaggaatg gttatctgct
    13021 gttccacttc ctccgcagcc agtccgggaa cttgagtgac cacctgggaa gtgacatctg
    13081 caatatccgg atatgcttct atcgaaagct gtttccatga gtaatatcca aagatacaca
    13141 tcatcacaaa caggcaaagc attacccatc ttttttgtat aattgaaagc attaattcct
    13201 tcttcataat ttcttacttt aaataatatc ctccttcact gattatctta tctccgggac
    13261 gcaatccttc gctgatcacc gctattccgt tttctgttgt ctccactgtc accgacgtcc
    13321 gtacgaaaac caacggagca atctgcacaa atacatagct atccttttcg ccctgcagta
    13381 acgctttctc cgggatttga atttgtccga ccggaacact cagaaagtgg acagtagtgt
    13441 acatccccag cttcagatgt ccgttcaaat tatcacagac cgaaagtacc tgaatggacc
    13501 gggtttcctc gtctacctcc tcctctacat gatacacatt gcctttaata accgtaccgg
    13561 gcaatgccga aatttcaata tccagactac tgccttcatt tataaaccgg atatctttct
    13621 cctttacctg agccgcaatc cataccttag acaggtcggc aacaatagct atcggttcgg
    13681 tatcgtcttt cagatattgc cctgttacga tgttatcctt tatcacttcc ccgggaatag
    13741 gagaacgaac aatcatcggt tgccccaata tcatttccac cggattgtcc acctgatata
    13801 cccgcaatgc ggcagaggcg ttttcaaact ccttatctgc tatcaataaa gcattctggg
    13861 cttcttccag ttctctttgc gaactgacac cattccttat cagatcttct ttgcgtttca
    13921 aatctttttt agcaagttcc ctggacgaaa gtgcctgaaa gtattccttt tgtgcagaag
    13981 taaagtcggg ggaactgatt tcaaataaag gtgttccctg acgtaccgac tgtccgatac
    14041 gcacataaga ttttgtgact ctccctgcaa atggaggagc aacataagca taacggggag
    14101 gaatgggacg caccacaccg gacgttatca ccttcttgga atagggtttc agttcagaca
    14161 ctgatacttt gatcttttca agtaaaagag gatctgcaat atagaccgtg tcaccttgta
    14221 tacgatagcc acttttttgc tctgattcct gtttatcccc gcatgcggta aaaaacaaca
    14281 cactgccaat aataaatgtg tgtaactctc tcttcatcat cataattaaa cataagttaa
    14341 gttagtaacc ggatttccgg gcacaaagat agacggctcc cttcggagag cctgttagag
    14401 aatagttaga atcctattag aatcttatta gagtaaataa agatttcttc ttaaaacagc
    14461 agctttgttg ttagagagta cgcacaaata aggggttgac taaaaagcca acccctcaac
    14521 ggatgatatt ccggtatttt tatcgtaagc cgaaaagttc ttattctttc acacaacgta
    14581 tactttgagc aaaaccttga tatgacaatc tgaaattatg agaattatat gcagactcaa
    14641 gcgaccaggc tccataacgt attctcctgt cataaggtgg attctgcaat tctgatctca
    14701 tataaggagg acctacactt gccgaccaat agtatccggt actaccccta ctttccaaag
    14761 caccacttgt gttattcaga cgaccggctg acggaaaaaa gacagatgca ttcgttccgg
    14821 aatcgggatt aaaatacaat actccctgat aagcaacatt actatttcct aatgatacgc
    14881 catagtttcc attcgaagcc tcttttatcg gacgtctgtc gaaaaatccg tccgaataaa
    14941 atgtataagt tgttcctttt agttgtttcc gggcaagcat atctttgttt gctccgtaag
    15001 gatatgtccc aggacctgta ttaccagttc caccaaaagg agtagtaaaa gctgtagcgt
    15061 agtctgcact tgaagccgca tttcctgcaa aaggtacatt aa
//
