LOCUS       c00043_gnlPro..        16209 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BHONKEMM_43.
ACCESSION   c00043_gnlPro..
VERSION     c00043_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 17:16:43
            Original ID  :: gnl|Prokka|BHONKEMM_43
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16209
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16209
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2657:6209](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2658..6209
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16209
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16209
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(85..1299)
                     /locus_tag="ctg43_1"
                     /transl_table=11
                     /translation="LNSFKMTKKALYIFNPEHDLALASGETNYMAPASARQMASELALL
                     PMWYAEEGSVVLAPSAYNLDYVKKIQELLGLSVDLMTEPELASERNLDIRPWGWDIAIR
                     KRLLDLGVEESELPSIEQLDKLRFCSHRSCAVGLLPQLQLGACFCGESFYLTFPEEWKS
                     FVESHDTCLLKAPLSGSGKGLNWCKGVYTPSISGWCSRIGKQQGGVIGEPLYNKVEDFA
                     MEFRSSSNGRFGFAGYSQFRTGGSGAYEGNLLISDAAIERNLLEYIPVEEIYKLRDRLE
                     QELSLRFGTIYNGYLGVDMMICRFPESPVYRIHPCVEINLRMNMGVVARHIYDHYIYPT
                     STGAFQISYYPTEGTAWRAHKEMEEAYPLEIEQGRIKSGYLSLVPAHKKSSYRAWVFIS
                     KSVFL"
     CDS             1447..2625
                     /locus_tag="ctg43_2"
                     /transl_table=11
                     /translation="MESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGIKGTRGVGKT
                     TFLLQYAKEKFGNDRSCLFINMNNFYFSGHSIVDFANEFQKRGGKVLLIDQVFKHPEWS
                     KELRMCYDRFPNLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREYLNLQTGMKFR
                     AYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENLLKTMNMMVE
                     VDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDIQTSRATVMNYIKYLADAR
                     LINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFVNSLWKDHKVHKGD
                     KNVSFMVDEVMPFKICQEGAKIKNNPNVTYALHKAEIGRGNQIPLWMFGFLY"
     CDS             2658..6209
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_3"
                     /sec_met_domain="PFOR_II (E-value: 4.6e-18, bitscore: 57.9,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 5.3e-82, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 5.3e-31, bitscore: 100.4,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.1e-11, bitscore:
                     37.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 1.8e-11, bitscore: 37.3,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 2.9e-08, bitscore: 26.0,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.00015, bitscore: 14.8,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 9e-25, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMNPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKTIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQILSVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIALEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLAVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNPENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKVFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKTKQHLVDIKSNVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTTNENGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARIVKLFNEILAADNASPEAKEVLKAWIENMYDADKTKE
                     LAPQVKAVIEEGLSHGCPICKELKGLTQYLVKRSQWIIGGDGASYDIGYGGLDHVIASG
                     KDVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQI
                     AMGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLW
                     RYNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPTEAEELFKAAEENAK
                     WRYNSYKRLARENWGAE"
     CDS             complement(6362..7228)
                     /locus_tag="ctg43_4"
                     /transl_table=11
                     /translation="MRIYKIVGIVLSAMLLLASCTNSDLEKKKVKIAYANWLEGIAMSH
                     LAKVVLEEHGYEVELQNADLAPIFVSMSGKKSDVFLDAWLPITMKDYMDQYGDSIEFFG
                     EVYGEARVGLVVPQYVTIHSINELEANKDRFSSEIVGIDAGAGIMKTTDKAIAAYGLDG
                     YTLMTSSSSTMLASLKKAMDKGEWIVITGWTPHWMFDQFDLKFLDDPKKVYGDLEEIHA
                     IAWKGFSEKDPFAAEFFGNIKLTTEELSSFMTAMKDARMDEEEIARKWRDEHRLLVDSW
                     IPKSENK"
     CDS             complement(7249..8073)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 92.9; E-value: 6.9e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg43_5"
                     /sec_met_domain="BPD_transp_1 (E-value: 9.2e-29, bitscore:
                     92.9, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIEMAINWMMIHFSTFFDAVNAGIGSFIIGFQHILFGIP
                     FYITILVLAALAWMKAGRGTAIFTALGLLLIYGMGFWEATMQTLALVFSSTCLALIVGV
                     PLGVWTANSSRAEKILRPVLDLMQTMPAFVYLIPAVLFFGLGAVPGVFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATRWQLLYKVQLPLALPTILTGVNQTIMMSLSMVVIA
                     AMIAAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIILDRITQGMAGRKNKN"
     CDS             complement(8070..9296)
                     /locus_tag="ctg43_6"
                     /transl_table=11
                     /translation="MSKIEIKDLYLIFGNEKQKALKMLKKDKSKEEILKDTGCTVGVKD
                     ANLSINEGEFFVIMGLSGSGKSTLLRCINRLIRPTTGQVLVNGVDISKISEKELLQVRR
                     KELAMVFQNFGLLPHRSVLSNIAFGLELQGVKKEEREKKAMESMKLVGLKGYENQMVGE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLALQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEVVQVGTSEEILTEPANDYVARFVENVDRSKIITASSLMID
                     KPLVARLKKEGPEVLIRKMRAKNITVLPVIDADDKLVGEVRLNDLLKLRSKQEKSIETI
                     VRTEVHSVLEDTVLEDILPLMTKSNSPVWVIDETREFLGTIPLSSLIIEVTGKDKEEIN
                     EIIQNAIDL"
     CDS             complement(9596..9934)
                     /locus_tag="ctg43_7"
                     /transl_table=11
                     /translation="MKDYKVDKASLSASFCQEVYQVVREIPVGKVSTYGGIAALLGMSQ
                     CSRMVGRALKQIPDDLSAPCHRVVNASGRLVPGWTEQKQLLLEEGISFKQNGCVDLKKH
                     LWNYSVPE"
     CDS             10018..11313
                     /locus_tag="ctg43_8"
                     /transl_table=11
                     /translation="MQLYLLYLQIIPTFVPIKSNPIINKTSTAVMKKKTILFASCLLGA
                     LAFSSCEKNLYDESKQPEKEKKMTDLEVPADFDWKGSQNAKVKIASQSTATISVFLEEN
                     CNEEALMLRMDVDANTSKLELPIEIPAYIKNVYVKYGNGSEIQTVPVESNGTISIVVPA
                     NATALSRVTTRANKEVETNNIFNYPGYGNGTIMFEDMYPALGDYDFNDFVAWYNFQIDG
                     FYWSHNQCYAEYLMIGFQIRAIGGIYDYNPYIRLAEVQYNELDLEETQMYLERNNPEEA
                     ENIKILKGPKGELIISLKKPAIPNGYKYYNTEVNEKTKPKKMMAIYLVFNSPVNVKSLQ
                     DSKMDFYIAKTNKGQEIHLKGYSPVYYNSNESYVNEDNFIWGLKVPASLHHAREEVNFL
                     EAYPDFEQWVTSGGQENQRWWNKPKTNKLIMN"
     CDS             complement(11453..14293)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 63; E-value: 1e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg43_9"
                     /sec_met_domain="Peripla_BP_1 (E-value: 1.3e-19, bitscore:
                     63.0, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEAMKYTKWITVLFCLLGLAACRQDAPRFRIGVAQCSDDSWRHK
                     MNDEILREAMFYDGVSVEIRSAADDNRKQAEDVHYFIDKGVDLLIISANEAAPMTPIVE
                     EAYQKGIPVILVDRKILSDKYTAYIGADNYEIGRAVGNYIASSLKGKGNVVELTGLGGS
                     TPAMERHQGFMAAISNYPDIKLIDKADAAWEREPAEVEMDSMLRRHPKIDAVYAHNDRI
                     APGAYQAAKKAGREKVMIFVGIDALPGKGNGLELVLDNVLDATFIYPTNGDKVMQLAMN
                     ILEKKSYPRETVMNTAVVDRTNAHVMQLQTTHISELDQKIETLNGRIGGYLSRVATQQV
                     VMYGGLVILLLVAGLLLVVYKSLRSKNRLNKELSEQKKQVEQQRDKLEEQRDQLIQLSH
                     QLEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADSSLSEDQRRMLLLVQRNVNILL
                     RLVNQILDFRKYENGKMEYTPISLDILSSFEGWNESFMAVARKKHIHFSFDYMPDTDYR
                     TLADVEKLERIYFNLLSNAFKFTPENGKVTVRLSSLTKDDHCWIRFTVANTGSMISAEH
                     IRNIFDRFYKIDMHHAGSGIGLALVKAFVELHKGTITVESDEKQGTIFTVDLPVQTCET
                     VVSENSPAFSVSATSVTSTDATTSAVAGVPATPATSGYSGSSSLNDALTYEEEELEKSY
                     DSSKPCVLIIDDNADIRLYVHGLLHTDYTVIEAADGSEGIRKAMKYVPDLIISDVMMPG
                     MDGIECCRRLKSELQTCHIPVILLTACSLDEQRIQGYDGGADSYISKPFSSQLLLARVR
                     NLIDSHRRLKQFFGDGQTLAKEDVCDMDKDFVEKFKALIEAKMGDSNLNVEDLGKDMGL
                     SRVQLYRKIKSLTNYSPNELLRIARLKKAASLLASSDMTVAEIGYEVGFSSPSYFTKCY
                     REQFGESPTDLLKRKG"
ORIGIN
        1 gaattttaat aggtttgcac tatatttgcg catcttgaaa aaacactttg tttcaagcag
       61 tgaaaccata acttcgatat aatatcacaa aaacacgctt tttgagataa acacccacgc
      121 ccgataacta ctctttttat gagccggcac caatgacaaa tagcctgatt ttattcttcc
      181 ttgttctatt tccaaaggat aagcctcctc catttctttg tgtgctctcc aggctgttcc
      241 ttccgtaggg taatagctta tttgaaaagc tcctgttgaa gtaggataga tataatggtc
      301 ataaatatga cgcgctacta ctcccatatt catcctcaag ttgatttcca cgcaaggatg
      361 aatccgataa acaggagatt ctggaaagcg acagatcatc atatccactc ccaaataacc
      421 attataaatg gttccgaaac ggagggataa ttcttgttca aggcggtcgc gcaatttata
      481 aatttcttcg acagggatat attccaaaag attccgttcg atggctgcat ctgaaatcag
      541 cagattacct tcgtacgccc cacttccacc cgtacggaat tgagagtatc cggcaaagcc
      601 aaatcgacca ttactcgaag aacgaaattc catagcaaaa tcttccacct tattatatag
      661 aggttcgcca ataacacctc cttgctgttt gccaatgcgt gagcaccaac cggaaataga
      721 aggagtatat acacctttgc accagttcag ccctttcccg ctaccggata aaggagcttt
      781 cagtaaacaa gtatcatgtg attctacaaa tgacttccat tcttcgggaa acgtcaggta
      841 aaaagactct ccacaaaaac aggctcccag ttgtagctgt ggtaataatc ccacagcgca
      901 ggaacgatgg gaacagaaac gcagtttatc caattgctca atagaaggaa gctcgctttc
      961 ttccactccc aaatccaaca gtcgttttct tattgctata tcccagcccc aaggacgaat
     1021 atccaaattc cgctccgaag caagttcagg ttctgtcatc aaatcaaccg aaagtcctaa
     1081 taattcctgt atcttcttca catagtcgag attataagcg gaaggagcca atacaacact
     1141 tccctcttct gcataccaca tcggcaacaa agccaattcg gatgccatct gccgggcgga
     1201 agccggtgcc atatagtttg tttcaccgct ggctaacgcc aaatcatgtt ccggattgaa
     1261 tatataaaga gccttttttg tcattttaaa cgaattcaaa actttattct gcaaatatat
     1321 acaggaaata gtcaggaatg gctacaataa acagaaagtt ctaattaaac tcacaatttt
     1381 gccatctcta ctttgcaaat cctaaaaaaa gcagtatatt tgccacccga aaaacaaaga
     1441 actgaaatgg aatcattcta tcgcacacac gcctacctcg ttgagcacac caatgccccc
     1501 gttcgccgcg atcttatgga cgagatcgac tggagcgacc gcctgattgg tatcaaaggg
     1561 acacgtggcg taggaaaaac cactttcctt ctccaatacg ccaaagaaaa atttgggaac
     1621 gaccgctcct gcctgttcat caacatgaac aacttctact tctctggcca cagcattgta
     1681 gactttgcta acgaatttca gaaacgtggc ggaaaagtat tgttgatcga ccaggtgttc
     1741 aaacatccgg aatggagcaa agagttacgc atgtgttacg accgttttcc taacctgaaa
     1801 attgtcttca ccggctcgtc cgtgatgcga ctgaaagaag aaaatcttga attacgtgat
     1861 atcgccaaga gctataacct gcgcggattt tcttttcgcg aatacctgaa cttacagaca
     1921 ggcatgaaat tcagggcata cagcctcgaa gaaattctta gcactcacga acagattgcc
     1981 aaaggagtac tctctaaagt tcgtccgctg gattacttcc aggattacct gcatcatggg
     2041 ttctatccgt tcttcctcga gaagcgtaac ttctcggaga atttgctgaa aacgatgaac
     2101 atgatggtgg aagtagatat acttctcatc aaacaaattg aactgaaata tctttcaaag
     2161 ataaaaaaat tactatattt gctcgctgtc gacgggccga aagctccaaa tgtgagccaa
     2221 ctggcaagcg acatacagac atctcgcgcc acggtgatga actatatcaa gtatctggca
     2281 gatgcgcgac tcattaatct ggtttatccg aaaggggaag aattccctaa aaaaccttcg
     2341 aagataatga tgcacaactc caacctgatg tattccatct acccggtgaa agtggaggag
     2401 caggatgtgc tcgacacttt ctttgtgaat tctttatgga aagaccataa ggtacataaa
     2461 ggagataaaa acgtctcttt tatggtggac gaagtaatgc cgttcaaaat ttgccaggaa
     2521 ggagcaaaga tcaagaacaa tccgaatgtg acgtacgcgt tgcataaggc tgaaataggt
     2581 cggggcaacc agatacctct ctggatgttc ggctttttat attaaaagat ttatttactt
     2641 aaatatttaa tttagttatg actaaacaga agaaattcat cacttgtgat ggtaaccagg
     2701 ctgcagcgca tatctcgtat atgttctctg aagtagctgc tatctacccc atcactcctt
     2761 cttcgactat ggctgagtac gtagacgaat gggctgccgc aggacgtaag aacatcttcg
     2821 gcgaaacagt attggtacag gaaatgcaat ctgaaggtgg tgctgccggt gcagttcacg
     2881 gttctcttca ggctggtgcg ttgactacta cttacactgc ttctcagggt cttctcctga
     2941 tgatccctaa catgtacaaa attgccggtg agttcttgcc ttgcgtattc catgtatctg
     3001 ctcgtacatt ggcttctcac gcattgtgta tcttcggtga ccaccaagac gtaatgtcag
     3061 ctcgtcagac tggctttgcg atgttggctg aaggctctgt acaggaagtt atggatttgg
     3121 ctggtgttgc tcacttggct actatcaaat ctcgtgttcc gttcatgaac ttcttcgatg
     3181 gtttccgtac atctcacgaa atccagaaga ttgaaatgtt ggaaaatgat gatcttgctc
     3241 cgctgattga tcaggaagct ttggctgaat tccgtgcccg cgcactgaat ccgatgaatc
     3301 cggttgctcg tggtatggct gaaaatcctg accatttctt ccaacatcgt gaatcatgca
     3361 acaactacta tgaagcagtt cctgctatcg tagaagaata catgaatgaa atttctaaga
     3421 ttacaggtcg taaatacggt ttgttcgatt attatggtgc agaagatgca gaacgcgtaa
     3481 ttatcgctat gggttctgta acagaagctg cccgcgaagc tatcgaccac ttggtagcaa
     3541 atggcgaaaa agtgggtatg gttgccgtac acctgtatcg tccgttctct gctaaacact
     3601 tcctggctgc tgtacctaag actgccaaga ctatcgcagt tcttgaccgt actaaagaac
     3661 cgggcgctaa cggcgaacct ctttaccttg acgttaaaga ctgcttctac ggcgcagaaa
     3721 atgctccggt tatcgttggc ggtcgctacg gtttgggttc aaaagatact actcctgctc
     3781 aaattctttc agtattcgag aacttggcca tgccaatgcc gaagaatcac ttcactatcg
     3841 gtatcgtaga cgacgttact ttcacttctc ttcctcaaaa agaagaaatc gctttaggcg
     3901 gtgaaggaat gttcgaagct aaattctacg gtttgggtgc tgacggtaca gtaggtgcta
     3961 acaagaactc tgtaaagatt atcggtgaca acactgacaa acactgccag gcttacttct
     4021 cttatgactc taagaagtca ggtggtttca cttgttctca cttgcgtttc ggtgatactc
     4081 cgatccgttc cacttatttg gtaaatactc cgaacttcgt tgcttgtcac gttcaggctt
     4141 acctgcacat gtacgatgta actcgtggtt tgcgtaagaa cggttctttc ttgctgaaca
     4201 ctatctggga aggtgaagaa ctggctaaga acctgcctaa caaggttaag aaatattttg
     4261 cacagaacaa catttccgta tactatatca acgcaacaca gattgcattg gaaattggtt
     4321 tgggtaatcg taccaacact atccttcaat ctgcattctt ccgtatcaca ggtgttattc
     4381 ctgtagacca ggctgttgaa cagatgaaga aattcatcgt taagtcttac ggtaagaagg
     4441 gtgaagacgt tgttaacaag aactatgctg ccgttgaccg tggtggtgaa tacaagactt
     4501 tagctgttga tcctgcttgg gctaacctgc cggatgatgc aaaagctgaa aacaacgatc
     4561 ctgcattcat caacgaagta gttcgtccga tcaatgcaca agatggtgac ttgctgcctg
     4621 tatctgcatt caagggtatc gaagacggta cttggtatca aggtacttct aaatacgaaa
     4681 aacgtggtgt agccgcattc gttcctgaat ggaatccaga aaactgtatc cagtgtaaca
     4741 agtgtgcata cgtttgtcct cacgcttcta tccgtccgtt cgtactcgat gctgaagagc
     4801 agaagggtgc taagttcgaa caattgaaag cagtaggtaa agtattcgac ggtatgacat
     4861 tccgtatcca ggttgacgtt ctcgactgtc tgggttgcgg taactgtgct gacatctgtc
     4921 cgggtaatcc gaagaagggt ggcaaagcat tgacaatgaa acacctcgaa agccaattgg
     4981 ctgaagctga caactggact tactgtgctg aaaacgtgaa gactaaacaa catcttgttg
     5041 atatcaagtc taacgtgaag aactcacagt tcgctactcc gttgtttgag ttctctggtg
     5101 cttgctctgg ttgtggtgaa actccgtatg tgaaattgat ttctcaattg ttcggtgacc
     5161 gtgaaatggt tgctaacgct accggatgtt cttctatcta ctctggttca gttccttcta
     5221 ctccgtatac tacgaacgaa aacggtcacg gtcctgcttg ggctaactca ctgttcgaag
     5281 acttctgtga attcggtttg ggtatggaat tggctaacga aaagatgcgt gctcgtatcg
     5341 tgaagttatt caacgaaatc cttgctgccg acaacgcttc acctgaagca aaagaagtgc
     5401 tgaaagcatg gattgaaaac atgtacgatg ctgacaagac taaagaattg gctccccaag
     5461 tgaaagcagt gattgaagaa ggtctttctc acggatgtcc tatttgcaaa gaactgaaag
     5521 gactgactca atatcttgta aaacgcagcc aatggatcat tggtggtgac ggtgcttctt
     5581 acgatatcgg ttatggtggt cttgaccatg taatcgcttc cggtaaggac gttaacatcc
     5641 tcgttctgga tactgaagtt tactctaaca caggtggtca gtcttctaag gctactccgg
     5701 taggtgctat cgctaagttc gctgctgctg gtaagcgcgt acgtaagaaa gacctcggtc
     5761 tgatggctac tacttacggt tatgtatatg ttgcacagat cgctatgggt gctgaccaag
     5821 ctcaaactct gaaagctatc cgtgaagctg aagcatatcc gggaccatct ttgattatcg
     5881 cttacgctcc atgtatcaac cacggtctga aagcaggtat gggtaagagc caggaagaag
     5941 aagaaaaagc tgttaagtgc ggttactggc acttgtggcg ttacaaccca gctttggaag
     6001 aagaaggcaa gaacccattc caattggata gcaaagaacc gaactgggaa gatttccaag
     6061 gtttcttgaa gggtgaagtt cgttacgctt ctgtaatgaa acaatatcct actgaagctg
     6121 aagaactgtt taaagctgct gaagaaaacg ctaaatggcg ttacaacagc tacaaacgtt
     6181 tggctagaga aaactggggt gctgaataat agtaataccc tataaatata aagcggtaat
     6241 cttatcaaag attaccgctt ttttattgta tgaactctgt ccaacataaa cagtactccc
     6301 tttttcccac tagagttcat gtctatttta tatttaaaat taagaataac aatgctccaa
     6361 tctatttatt ctctgacttc ggaatccaac tatccaccaa cagccgatgc tcatccctcc
     6421 atttacgggc tatttcttct tcatccatcc tggcatcctt catagctgtc ataaaagagc
     6481 taagttcttc tgtcgttagt ttgatgttgc caaagaattc ggcagcaaac ggatctttct
     6541 cactgaatcc tttccatgca atagcatgta tttcttccaa gtctccatat actttcttcg
     6601 gatcatccaa gaatttcaag tcaaactggt cgaacatcca atgcggtgtc caccccgtaa
     6661 tgacaatcca ttctcctttg tccatcgctt ttttcaaaga agccagcatg gtggaactac
     6721 ttgaagtcat gagggtatac ccatcaagtc cgtaagcagc aatggcctta tcggtcgtct
     6781 tcattatccc tgctcccgca tcaattccta ctatttcaga ggaaaaacgg tctttattag
     6841 cttccagctc attaatagag tggatcgtaa catattgagg aacaaccagt ccgacgcgag
     6901 cttctccgta tacctcccca aaaaattcga tgctgtctcc atactgatcc atataatctt
     6961 tcatcgttat tggtaaccat gcatccagaa acacatctga tttctttcct gacatagata
     7021 caaaaatagg ggcaagatca gcattttgca attcaacctc atatccatgc tcttccaata
     7081 ccaccttagc caaatgactc atggcaatac cttccagcca attggcatag gctattttta
     7141 ctttcttttt ctctaagtct gaattagtac aggaagctag caaaagcata gctgacaata
     7201 ctattcctac tattttatat attctcatac gtattttatc ctttccgttt agttcttatt
     7261 ttttcgtcct gccattcctt gcgtgatacg gtctaagatg atagctaaaa taacaactgc
     7321 tataccacct tcaaacccaa gtccgatttt catttgggta atacctttca atacaatttc
     7381 tcccagacca ccggcagcaa tcatggcagc aattacaacc atagaaagcg acatcattat
     7441 tgtctggttg acaccagtca gaatggtggg caacgccaaa ggaagctgca ctttatacaa
     7501 taactgccaa cgggtagctc cgaacgaacg ggaagcttcc actacatttt taggaacttg
     7561 ccggattccc aatccggtaa ggcggaccac aggaggcata gcaaagataa tggtggcaaa
     7621 cactcctggc actgctccca atccgaaaaa caaaacagca ggaatcagat aaacaaaagc
     7681 aggcatcgtc tgcatcaagt cgagaacagg acggagtatt ttctctgcac gcgaactgtt
     7741 tgccgtccat actcctaaag gtacaccaac aatcagggcc agacaggtag atgaaaaaac
     7801 gagagctaga gtttgcatgg tagcctccca gaatcccatt ccatagatca gtaataatcc
     7861 caatgcggtg aaaattgccg taccgcgtcc tgctttcatc catgcgagtg cagcaagtac
     7921 caaaatggtt atataaaaag gtattccgaa aagtatgtgt tggaatccta taataaaact
     7981 accgatgccc gcattcacgg catcaaagaa agtggaaaaa tgtatcatca tccaattgat
     8041 ggccatctct atatattgtc ctatatttat cataaatcta ttgcgttttg aattatttcg
     8101 tttatttctt ctttatcttt cccggtcact tcgatgatta aggatgaaag cgggattgtt
     8161 cctaaaaact cgcgcgtctc atcaatcacc cataccggcg aattgctctt tgtcattaga
     8221 ggaagtatat cctccaacac cgtatcctcc aacacagaat gtacttctgt acgcacaatc
     8281 gtttcaatgg atttttcctg tttgctacgt aacttaagca agtcgttcag acgtacttct
     8341 ccgaccagtt tatcatcggc gtctatgaca ggtaatacgg tgatattctt cgcacgcatc
     8401 ttacgaatca atacttcggg accttctttc ttcagacggg ccaccaacgg tttgtcaatc
     8461 attaaagaag aggcggtaat aattttgctc ctatccacgt tttcaacaaa acgggctaca
     8521 taatcgttag ccggttcagt caggatttcc tccgaagtac ctacctgcac cacttctccg
     8581 tctttcatga tggcaatacg gtcacctagc ttaattgctt cactcaagtc gtgggtaata
     8641 aaaacaatcg tctttttcat ctttgattgc aaggccagta gttcatcctg catctgtacg
     8701 cgaatcagag gatcgagagc agagaaagcc tcatccatta aaagcacttc aggattatta
     8761 gccagagcgc gagccagtcc gacacgctgt tgcattccac cggaaagctc gcctaccatc
     8821 tgattttcat atcctttcaa tccgacaagc ttcatgcttt ccatcgcttt cttctcacgt
     8881 tcctctttct tcactccctg aagttcgagg ccgaacgcga tattgctcaa tacggaacgg
     8941 tgaggtaaca gaccgaaatt ctggaaaacc atcgccagct ctttccgacg aacctgcaat
     9001 aattcttttt cggaaatttt agatatatct actccgttta caagcacttg cccggtagta
     9061 ggacgtatca gacgattgat acaacgcagt aatgtcgatt ttccacttcc cgagagtccc
     9121 attatcacga aaaactctcc ttcattaatt gaaagattgg catctttcac tcctaccgta
     9181 caaccggtat ctttcagaat ttcctcttta ctcttatctt ttttcaacat cttgagggct
     9241 ttctgcttct cgttaccaaa gataaggtac aaatccttta tttctatttt actcatataa
     9301 tatattggtt tagattataa tatttgtttt gttttcaact gccgcattcc ttattctcac
     9361 ttacgataaa caagttgaat gttcgcatgg ttcagtcatg tcacatgata acatgacggt
     9421 ccgacgtttt ttaaatggtt aaaaaaaaac agacagagta gtttaaaagg aatagaattt
     9481 gataagatta tcctcttaat gaacagtaga aaacagtatt ttcataaata aataacagtc
     9541 tgttcttgca tattgttggc acaaaggtaa ggaaaataga ttaaatatgc aaatttcatt
     9601 caggtacgga gtaattccaa agatgctttt tcaagtctac gcatccattt tgtttgaaag
     9661 agatcccttc ttccaacaag agttgtttct gctctgtcca acccggaaca agccgtcccg
     9721 acgcattgac aacccgatga caaggcgcag ataaatcatc cggaatctgt ttcaaagcac
     9781 gccccaccat acgggaacat tgagacattc ccaataatgc ggcaattccc ccataggtag
     9841 aaactttacc taccggaatt tctcggacaa cctgatacac ctcttgacaa aaggatgcgg
     9901 aaaggctcgc cttatctact ttataatctt tcatcactca aacattactt tatttcagtt
     9961 ccaaaactag ataaaaagaa aagaatttgc aaataataaa agcatttcaa ataaaatatg
    10021 caactttatt tgctttattt acaaataatc ccgacctttg tacccattaa aagcaaccct
    10081 attattaaca aaacaagcac tgctgttatg aaaaagaaaa ctatcctgtt cgcttcttgt
    10141 ttattgggag cactggcttt cagctcctgt gagaagaacc tttatgatga aagtaaacaa
    10201 cccgagaaag aaaagaagat gactgacttg gaagtacctg ccgatttcga ctggaaaggt
    10261 tctcaaaatg ccaaagtgaa aattgccagt caatcaactg ctactatttc tgtatttcta
    10321 gaagaaaatt gcaatgaaga ggctttgatg cttcgaatgg atgtcgatgc caacacatca
    10381 aaattggaac tcccaattga aattcctgca tatataaaaa atgtgtatgt aaaatatggt
    10441 aatggctctg aaatacaaac tgttcctgtt gaaagtaatg gtactatttc tatagtagta
    10501 cctgctaacg ctacggcatt atccagagtt accacaagag ctaataaaga agttgaaacg
    10561 aacaacatct tcaattatcc gggatatggc aacggaacta ttatgttcga agatatgtat
    10621 ccagctttag gcgattatga ttttaatgat tttgttgcat ggtataattt ccaaattgac
    10681 ggtttttatt ggagtcacaa tcaatgttat gcagaatact taatgatagg attccaaatc
    10741 agagctatag gaggtatata tgactacaat ccttatatcc gcttggcaga agtacaatat
    10801 aatgaacttg atttagaaga aactcaaatg tatcttgagc gtaacaatcc tgaagaggct
    10861 gaaaatatca aaatcctaaa aggcccaaaa ggggaattga ttatttcact aaagaaaccg
    10921 gccattccta acggatacaa gtattataat acggaggtaa atgaaaaaac aaagcctaaa
    10981 aaaatgatgg ccatttactt ggtgttcaac tcacctgtta acgttaaaag cctacaagac
    11041 agtaaaatgg acttttatat tgcaaaaact aataaaggac aagaaatcca cttaaaaggt
    11101 tatagcccgg tttattataa cagcaacgaa agttatgtaa atgaagacaa ctttatatgg
    11161 ggattaaaag tacctgcatc tttacatcat gccagagaag aagtaaactt cttggaagca
    11221 tatccagact ttgaacaatg ggtaacatcg ggaggtcaag agaaccaaag atggtggaat
    11281 aagccaaaaa cgaataagtt gattatgaat taataaatat acagtaaatc atatactgaa
    11341 ttaaataaga ggtaaggtat gtcaatagat ttccttacct cttattttta tcatatgaat
    11401 tctagaagta taaacagata aatgctcacc accaaatttt gcagattcta tcctatcctt
    11461 tcctcttcaa caaatctgtc ggactctctc caaactgttc tctataacat ttagtaaaat
    11521 aagaaggaga actaaaacca acttcataac ctatctctgc cactgtcata tccgacgaag
    11581 caagcaggga agcagctttc ttcaaacgag ctatacgaag cagttcattc ggggaataat
    11641 tagttaggga tttgattttg cgatagagtt gcacacggct taatcccata tctttaccca
    11701 agtcttccac attcaaattt gaatctccca tctttgcctc aatcaaagct ttgaattttt
    11761 ccacaaagtc tttatccata tcacagacat cctctttcgc caacgtttgt ccgtcaccaa
    11821 aaaactgttt caggcggcgg tgtgaatcta tcagattacg aacgcgtgcc aatagtaatt
    11881 gcgaactgaa aggcttggag atataagaat ctgcaccacc atcataccct tgaattcgtt
    11941 gttcatccaa agaacaagct gtcaatagga taacaggaat atgacaggtt tgtaattcgc
    12001 ttttcaagcg acgacaacat tcaattccat ccattccggg catcattaca tcggagataa
    12061 tcaagtccgg gacatatttc atagctttac gaataccttc cgagccgtct gcagcttcta
    12121 taacagtata atcagtatga agcaatccat gcacatataa gcgaatatca gcgttatcat
    12181 caataatcag aacgcaaggt ttggaagagt cgtaactttt ttccaattcc tcttcttcgt
    12241 aagttaaagc atcattcaag ctcgaagaac cggaataacc ggaagttgca ggagttgccg
    12301 gaaccccagc aacggcagag gttgtagcat cggtggaggt tacagaagta gcagacacag
    12361 agaatgccgg agagttttca gaaacaacag tctcgcaagt ctgcacaggc aaatcaacgg
    12421 taaagatagt tccttgcttt tcatcacttt ccaccgtgat ggtaccttta tgcaattcca
    12481 caaaagcctt taccaatgcc agtccaatac ccgaaccggc atggtgcata tctatcttat
    12541 agaaacggtc gaaaatattc cggatatgct ccgcagaaat cattgaaccg gtattggcaa
    12601 cggtaaagcg aatccagcaa tgatcgtctt tagtcaggga agacaagcgt acagttactt
    12661 ttccgttttc cggagtaaat ttgaaagcgt tggaaaggag gttgaaatag atgcgttcca
    12721 acttttctac atctgccaat gtgcggtaat ccgtatccgg catataatcg aatgagaaat
    12781 gaatatgctt cttccgggct actgccatga aagattcgtt ccatccttca aaagaagaaa
    12841 gaatgtctaa cgaaatagga gtatattcca tttttccatt ctcgtattta cgaaaatcca
    12901 gaatctgatt gacaagacgc aaaaggatat tcacgtttcg ctgaactaac aataacattc
    12961 ggcgctgatc ttcactcaaa gacgaatcag ccagtaaatg ctctaccggg tcggcaacta
    13021 atgtcagtgg agtacgaaaa tcgtgagata tatttgtgaa gaaaaccagc ttggcatgag
    13081 tcgcttcttc cagttgatga gaaagctgga taagctgatc ccgttgctct tcgagtttat
    13141 cgcgctgttg ctctacttgt ttcttctgtt cggacaactc tttattcagg cgattcttgg
    13201 aacggaggga tttatagact accaacaaca atcccgctac taataaaaga ataaccaagc
    13261 cgccatacat cacgacctgc tgcgtagcta cacgcgacag atacccaccg atacgtccgt
    13321 tcaatgtttc aatcttctga tccagttccg agatatgggt agtctgaagt tgcataacgt
    13381 gcgcgttcgt gcggtctaca acggcagtat tcatgaccgt ttcgcgagga taagacttct
    13441 tctcaagaat attcatggcc agttgcatca ctttgtcccc attagtcgga taaataaaag
    13501 ttgcatccag cacattgtca agcaccaatt caagcccgtt tcctttgccg ggcagggcat
    13561 caatgccaac aaaaatcatt accttttcac gtccggcttt cttcgcagct tgataggctc
    13621 ccggagcgat acggtcgtta tgtgcatata ccgcatcaat cttcggatga cggcgaagca
    13681 tactatccat ttccacttct gccggttcac gttcccaggc agcatccgct ttatcaatca
    13741 gtttgatatc cggataattg ctgatagcag ccataaatcc ctgatggcgt tccatggcag
    13801 gggtggaacc acccagtccg gtaagctcca ctacattccc tttccctttc agacttgatg
    13861 cgatataatt tcctaccgca cgacctattt cataattatc ggcaccgata taggcagtat
    13921 atttatcaga aagtatcttc cggtctacaa gaatgacagg tattcctttc tgataggcct
    13981 cctccacaat tggagtcatg ggagccgctt cattggcgga aattatcagt aaatcaactc
    14041 ctttatctat aaaataatga acatcttccg cctgcttacg gttatcatcc gccgccgagc
    14101 ggatttcaac cgacactcca tcataaaaca tcgcttcgcg aagaatctca tcattcatct
    14161 tgtgcctcca agagtcatcg ctacattggg ccaccccaat acggaaacga ggcgcatcct
    14221 gccgacaggc cgccaagccc aaaagacaaa acaagactgt tatccacttc gtatatttca
    14281 tcgcttcaat cattcccttt ctttcgtata tcttttgtat ttctttctgt aatccaaatt
    14341 tctccccccg cattatttgc attcaccacc gggaaataca tcagttccac tttcacaggg
    14401 ttcagcgtat attttccagt aaagcgtgga agcaaaggaa ccgtaaactg ataagtacct
    14461 accggtaatt tttcgctaaa gataacagtt ttctctttaa aatactcacg atatacttca
    14521 gaacgggaga aattaacagg ttttgaggca taactacaac ctgccggaac aggaacttcg
    14581 agcatcacat attgcgcacc ctcctgtttc acctgcaagg taactgtcaa tgtaacaggt
    14641 acacccgcca ccaaagagtc tttttccaaa gtcacctcca ccttgaaagc atcactctga
    14701 cgagcattca tcacacgctt cattgaatag acactataca ataaaggctc ttttcccgtt
    14761 tttgaaataa gcagactgtc gcttgctgtc agccgggcat gataaggaaa ttccgtaatt
    14821 cgttgatgat ccttaccgct cacagacacc gacgttcctg acatccctcc ggaacctgcc
    14881 agcaaatcgg tcagaacagt tgccacagcc gaagaagcct gatacgtatt ccatccgcgc
    14941 tccttagtcc gcaaaatata caattgcata ttttctttca acttacacag ggaagggtca
    15001 tttttaataa tccggtaggc tatcaatgta tttatcatct gatttccctc ccaataataa
    15061 gtacgccgtc cgtcgtcaca gtaaacacct tccagcatat cctttttcag ataaggacgt
    15121 acgctatcat ccacattcac cgaatccacc tgttgcttga tttcccagag aagcagcttc
    15181 tctttcaagt atgaaagagg acgataatac ttgtttctat ttgccaacga gtcttctttc
    15241 tgttccaatt gccggacgaa aggttccaat aatctgactg ccgaagaata atccgcctct
    15301 actttccact catgcagagc atgaagtatt tctatatctt ccagtttcat tcctcgataa
    15361 ggacgcgtat gagcatactc cactttcaaa ccattcagat tcaactccac aggataacct
    15421 gcatcttgcg ccatcttcaa agcccgcaga atatgcgcag acatccagaa agaagtattt
    15481 tcagagttcc cccaccacga ccataactga tgtttgttct gatgattcgt cagtcgatgg
    15541 atgataggtc gaattgcttt atctactttc accttttcac ccttactctg catatactgt
    15601 tggtaagcca acaaaccgat taacttggat gccagctgct cattgcacaa atatttgtat
    15661 cctgtcaagt aattcactga ttctttatag atgtccaact gattgtcagt gatactcacc
    15721 atcacttctt catcctcgcc ggattgcact ttaaccgtct ttgcatcgga cagaataccc
    15781 aatgtgccct ccgccaattc agttccctgt gccagtatcg gaatcgtata ttcctctcca
    15841 tcctgatagc catcgtcgcg agtgaaaaga tagctgatgg tcacgctatc ggcatgaact
    15901 gcctgcatcg gcactgtttc atgaaatccc tccatgaaac tcacttcctg ccgtttcaac
    15961 gtatccgttc cgacgcagaa ctgtgtcttt ccggctatgt gctgcccatc cagataattg
    16021 cggatagtcc cgaccaccgt actctgatcc ccctccacca agaagcgggg agttttcaac
    16081 tccgccatca acggtttgta agagcggacg aaacgtcgga aagtacccgt ctgcaaacga
    16141 cggttcatgc cataaacgac agtttcccat ttcgtcacat tatcggggaa agttgtttca
    16201 aactgtacc
//
