LOCUS       c00049_gnlPro..        16415 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GIANEHGH_49.
ACCESSION   c00049_gnlPro..
VERSION     c00049_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 18:37:57
            Original ID  :: gnl|Prokka|GIANEHGH_49
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16415
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16415
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1651:6415]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1652..6415
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..16415
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16415
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             complement(374..871)
                     /locus_tag="ctg49_1"
                     /transl_table=11
                     /translation="MSVYKSKFQPVMERWSLVLKIVLLTTGLMFLLRTFMLQSLQDQIA
                     SLLFGAILVSIYIYMLIVIPSFICLEKDQLVIKRVFGKKCIPYSCIKNAFVYDGVQNDV
                     RYFGSNGFLGYIGVMGSTHYGKYYSYVKNPNQQIFILTEKKNYLLSCENRDMFIKDLLI
                     HL"
     CDS             complement(871..1662)
                     /locus_tag="ctg49_2"
                     /transl_table=11
                     /translation="MKSKILTLGVGAAIAATSFSSCDNSNDFPNLAIASEENFVDDETT
                     AISMKKLSQEEQVYIHDMSLLSHNILNDTNAAEAFLNAPLEYARSLGIKSSIDTDDGTV
                     RFLLAICKPEFREAVIKRDIRRFVELCEKYDIFKNANSSNIKLLNHTAITRSKNCVDVQ
                     MGFFWIGEWILLGVAYVGAGIDYAALGGPVVCASRTINSEMALQVWDVETQDGSVYELA
                     DEYKNHYVQDLVKLVKEKRPEVMERYTDKELIEIIQKTLAI"
     CDS             complement(1652..2698)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg49_3"
                     /sec_met_domain="Radical_SAM (E-value: 3.8e-10, bitscore:
                     32.6, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELLNFISPNTLSLLTTYYCTAACKNCCFECNQERRGRMSFKQME
                     TYISECVKAFPTIRLVVFSGGECFSLKDDLYQAIYYAHKKGLITRVVTNGYWAVSYEKA
                     LGILVLLKELGLNELNLSTGDDHQKWVPFDNIVNAIRAAAKVDLPCLVNIETNPSSQFS
                     EEDFKNHEELKEYIRDNKVIFSSGIWIPFDMEDKIKRDTNYNELIKHRYVQRPIISHGC
                     NSLFESIPIDPEGNVYACCGLACRKAKFLKIGNMNTAGINKIYTRQFDDFLKVWAYVDG
                     PKFILNKIAMETGKNIEVNADMHNCEACLLLLNDPSKIEYIKNNISRYISEVVLKYNIK
                     QKKANYEK"
     CDS             3108..3314
                     /locus_tag="ctg49_4"
                     /transl_table=11
                     /translation="MFIAERQGFEPRVPRSTTVFKTAAIDHSATSPELRLSSAFLLKRC
                     KGTNHFLTCKLFRKKILEKYIWK"
     CDS             3457..5685
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg49_5"
                     /sec_met_domain="Gly_radical (E-value: 2.6e-46, bitscore:
                     148.8, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate1 (E-value: 0.0, bitscore:
                     1164.8, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELNKTFKDGLWSKEINVRDFVSNNITPYEGDASFLQGPTERTKA
                     VWNHCLKALEEERNNNGIRALDYTTVSTITSHPAGYIDKENELIVGLQTDQVLKRAIKP
                     FGGINVVMKACRENGVEVDDRVKDIFTHYRKTHNDGVFDVYTEEIRSFRSLGFLTGLPD
                     NYARGRIIGDYRRLALYGLDRLIEAKKEDLHNLTGPMTEARIRLREEVAEQIKALKEIK
                     VLGEYYGLDLSRPAYTAQEAVQWVYMAYLAAVKEQDGAAMSLGNVSSFLDIYLEYELSQ
                     GTITETFAQELIDQFVIKLRMVRHLRMQSYNDIFAGDPTWVTESIGGRFNDGRTKVTKT
                     SFRFLQTLYNLGPSPEPNMTVLWSPELPEGFKAFCAQVSIDTSSVQYENDDLMREVRQS
                     DDYGIACCVSYQEIGKQIQFFGARANLAKALLLAINGGRCENTGTVMVKDIPVLTGETL
                     KFEEVMANYKKVLIQIARVYNEAMNIIHYMHDKYYYEKAQMAFVETDPRINLAYGVAGL
                     SIAIDSLSAIKYAHVKARRNDIGLTEGFDIEGAFPCFGNDDDRVDHLGVDLVYFFSEEL
                     KKLPVYKNARPTLSLLTITSNVMYGKKTGATPDGRAKGIAFAPGANPMHGRDKNGAIAS
                     LSSVAKLRYRDSQDGISNTFSIVPKSLGATQEDRIDNLVTMMDGYFTKGAHHLNVNVLN
                     REMLQDAMEHPEKYPQLTIRVSGYAVNFVKLSREHQLEVISRSFHERM"
     CDS             5690..6415
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 72.3;
                     E-value: 1.6e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg49_6"
                     /sec_met_domain="Radical_SAM (E-value: 3.5e-30, bitscore:
                     97.8, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINVHSYESMGTFDGPGLRLVVFLQGCNFRCLYCANPDTIEAKGG
                     TATDPEEIVRMAVSQKAFFGKKGGITFSGGEPTFQAKSLIPLFKRLKEAGIHICLDTNG
                     GLWNNDVEELLELTDLVLLDIKEFNPEHHQSLTGRSNEQTLKTAAWLETNHKPFWLRYV
                     LVPGYSDFEDDIRQLGEHLGTYQMIQRVEILPYHTLGVHKYEAMNKEYMLKGVKENTPE
                     QIEKAEKLFRQYFRTVQVN"
     CDS             complement(6648..7910)
                     /locus_tag="ctg49_7"
                     /transl_table=11
                     /translation="MMKEDEKWIKAFKDKLEDYSEPMPASGWERLERELMPVTEKRIYP
                     YRRWAVAAAAVVLVVTTAVSLYFLNSPVADEIRYATAPSLAVNPDVLPEPALPDVQVAV
                     SEPVKPVGTTSINPVSGYLAKNTDPVIVPEVSSLAEKQPEAVTEEKRAEPQQEATAAIE
                     KKESVTAQPPKRKEARRPSGKDKYQLPIGDSSAKRGGKWSMGVGIGNGGGLPTNGSENF
                     APRPMTNRVDLMTIMNGAVSIPADQEVIFEEGVPYLKSNTTAVVDYEHHQPVSFGLSVR
                     KSLPKGFSVETGLTYTLLSSDIKRQGDTKMQSQKLHYIGIPVRGNWNFLEKKYFTLYVS
                     AGGMVEKCVYGKLADDKVNVKPLQFSVAGVVGAQFNATDHVGLYVEPGVSYFFDDGSKV
                     QTIRKERPCNFNLQAGLRFTY"
     CDS             complement(7962..8510)
                     /locus_tag="ctg49_8"
                     /transl_table=11
                     /translation="MNELELSERCRQGDNRARKELYEQYAGRMLGVCLRYAGDRDMAQD
                     LVHDGFLKIFDSFDKFTWRGEGSLRAWMERVMVNTALQFLRKNDVMNQTTALDEVPETY
                     EEPDASAVEAIPQKVLMQFINELPAGYRTVFNLYTFEDKSHKEIAQMLGINEKSSASQL
                     FRAKSVLAKKVKEWLVTNG"
     CDS             8698..9450
                     /locus_tag="ctg49_9"
                     /transl_table=11
                     /translation="MKKFNLITFAVILMLLPILQSCLDDANNDEWVTCPPGGILAIGTM
                     KIPNADTPRDFFIALDNGDNVLPADTADIRNRKYTVAEGQRVFVGYLQMGEEKPGYENG
                     KIFTIEDILTKEIIPLTEATADSIGDDRINVTAHALTKDYLTIEYQYLGSMNENKKHML
                     NLVQNEITGPIKDDGYIYLEFRHNAFNDSPNQLGSSLVSFKLDSIAEQLATAKGIKLRV
                     NTIYDNIQYVTIDINEDKNLKIKSFHSQ"
     CDS             complement(9555..10553)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     -3.5; E-value: 38)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg49_10"
                     /sec_met_domain="LysR_substrate (E-value: 1.3e-46,
                     bitscore: 150.8, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 5.4e-18, bitscore: 57.0,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRVKLKISIFALIDSISLINQRTMTIQQLEYILAVDQFRHFAKA
                     AEYCRVTQPTLSAMIQKLEDELGVKLFDRSMTPVCPTAIGKKVLEQARKILSEVICVKE
                     IISEEQHSLSGTFRLAVLPTIAPYLLPRFFPQLMEKYPDLDIRVMEMKTPDIRKALLTG
                     EADAAIIASMLDDAALTEETLFYEQFLGYVSKKEPLFKHDVIRTSDVTGERLWLLDEGH
                     CFRDQLVRFCQMEAVKISQMAYRLGSMETFMHMVESGKGITFIPELAVMQLSEEQKELV
                     RPFAIPRPTRQIVLVTRKDFIRTSLLQVLKEEIQAAVPKEMLTLQAVQCLV"
     CDS             10623..11096
                     /locus_tag="ctg49_11"
                     /transl_table=11
                     /translation="MKTLNYTHLEEKGANTIVLSLQQLLADFQIHYANLRGFHWNIKGH
                     GFFVLHSKFEDLYNGAAEKVDEIAERILMLGGTPANKYSDYLKMAQIKEVDGVNKADDA
                     LNHILETYGHLIAEERKILSLASSHNDEVTVAMMSDYLKEQEKMVWMLTAYNG"
     CDS             complement(11200..12198)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_hydro_130"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg49_12"
                     /sec_met_domain="Glyco_hydro_130 (E-value: 1.6e-69,
                     bitscore: 226.4, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEIKIAGAALPAMPWEERPAGCKDVVWRCSANPIIPRDLLPTSN
                     SIFNSAVVPFKDGYAGVFRCDDTNRRMRLHVGFSKDAVHWDINEEPLKFQCDDAEVGTW
                     VYGYDPRVCFIEDRYYVTWCNGYHGPTIGVAYTYDFVTFHQLENAFIPFNRNGVLFPRK
                     INGRFAMLSRPSDNGHTPFGDIFYSESPDMEFWGRHRHVMSPAPFEDSAWQCTKIGAGP
                     IPIETSEGWLLIYHGVLASCNGFVYSFGSALLDIDQPWKVKFRSGPYLISPQKDYECMG
                     DVPNVCFPCAALHDSETGRIAIYYGCADTVTGLAFGYIPEIIEFTKRTSII"
     CDS             complement(12253..13521)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg49_13"
                     /sec_met_domain="MFS_1 (E-value: 4.5e-11, bitscore: 34.4,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKPISPVCWVPTVYFAMGLPFVALSMVSVLMFSDMEVSNAQIA
                     FWTSLIMLPWTLKPLWSPFLEMFKTKKYFVVATEIITGLAFALVALSLPLPDFFRYAIA
                     LMGIIALSGATHDIAGDGVYLTELTATQQAKYIGWQGAFYNLAKILANGGLVWLAGMLK
                     DEFGVVHAWMIVMLMCAGIMILIGLYHIRILPSGGGASGEVNTMSDALNMLWEVIRSFF
                     QKKHIAFYIVFIILYRFAEGYAIKIVPLFLKASVADGGLGLSTQDIGLVYGTFGAGAFI
                     LGSLLAGYYISAFGLRKTLFSLCCAFNIPFLVYFLLALYQPSDLWIIGMAIVSEYLGYG
                     FGFVGLMLFMMQQVAPGKHQMAHYAFATGIMNLGVMLPGMMSGYLSDWLGYRDFFIWVL
                     IATIPAFIVTWLVPFTYPDGKKK"
     CDS             complement(13771..14784)
                     /locus_tag="ctg49_14"
                     /transl_table=11
                     /translation="MNRHLNFVTLICLITGFVSLASCSNDDDEMDKYQKIYIRTGVAPG
                     AEMGAAVVVDCVSNSSTADRSDFEIQLCAVQPVTRDVTAALGVDTLKVDTYNSANKTKC
                     KLLPQDNYTIETSEVVLKTGQTVADSSFQVVLKNIEKLTNPDGYVLPVTLKGVTGMDEQ
                     AVSTSMKTVYIRIYTSVLYTSYTKPGNWSAVDRSAWSVSCSNVYADDDAKYGAHLAIDG
                     EINTTWFTWGVANAGECWWNTVLDRPVTLTGFSVTKQSAYGSGYNLRSAEIKVRKEGET
                     EWVTYPRVLTFRNFKGADPQYAAIEPPIPNVKEFRINCLTPDNYTGFAEINLYVKQ"
     CDS             complement(14807..15943)
                     /locus_tag="ctg49_15"
                     /transl_table=11
                     /translation="MKRITIKQCLFACFVLPMILAGCNDADYQVIDNAIYLNEASENGS
                     AKVTVDPENVTTTTLTVRVGQPVTENVTAVLTVDPSILKEYNEANETSYEVLPEQYFTY
                     DKEIKIAAGDVSAIPSEFRVKPYSNENGELYAIPVSLTEIQGPVSTIGLSSKFIILLDK
                     PLIQSVPFMNTTNAVKPAKDELWGVTTNEWSLEAWVQMDGFDINNQAIFNSGSSDHEVY
                     IRFGDAMIPYNSLQVKTLGSQVNTVTLFEKNKWYHLAFVYNSSGLLSIYINGVLDVTLQ
                     TKGGPVRFDKMNMVSSGSYFRNNCQMAQVRLWKSAISQTQIQSNMYFAVKPADPNLIGY
                     WKMDEGKGNAFADCTGHGYDLVAGGTLVWKEHVRFDKQ"
ORIGIN
        1 tttttatgct ttataagctg ctggaaagtg aacgggtatg ctccggaata tgtataacaa
       61 tgtcatcaac gatacaatat cccctttgta aattatacaa taaataatag ctaagcaacc
      121 aaagacagtg caaagcccaa caagtaataa aagaacaaag tattaaataa agcaaaaaca
      181 cccaatttta ctttttaggg tataaaattg ggtattactc ttgtaattca cagattttca
      241 acatttattg cagagataca gggtttaatt attaatgctc taaaaaacta acgggaagaa
      301 taaaaaacat attcttcccg tcaagtaata ctataactat attttccaac aggttatatt
      361 aatatccagc atattataag tgaatcaaca aatcttttat aaacatatct ctgttctcac
      421 agcttaagag gtaattcttt ttttctgtta atataaaaat ttgttgattg ggattcttta
      481 cataggaata atatttccca taatgggtac tccccattac acctatatac cccaaaaagc
      541 cattacttcc aaaataacgg acatcatttt gaacaccgtc ataaacaaaa gcgttcttaa
      601 tacaagaata cggaatacat ttcttaccaa acactctttt tataacgagt tgatcctttt
      661 ccaaacatat aaatgaagga atcactatca gcatgtatat gtatatagat acaagaatgg
      721 caccaaataa caggcttgcg atttgatcct gcaaagattg tagcataaaa gttcttaata
      781 gaaacataag gccagtagtt aataagacaa tctttaatac cagagaccaa cgctccatta
      841 ccggctgaaa ttttgattta tatacgctca ttatattgct aatgtcttct gtattatttc
      901 aataagttct ttatccgtat atcgttccat aacctcagga cgtttttctt ttactaactt
      961 aaccaaatct tgaacatagt gatttttgta ctcatctgct aactcatata cacttccgtc
     1021 ctgtgtttca acgtcccaaa cctgcaatgc catttcactg ttaattgttc tggaagcaca
     1081 tactacggga ccaccaagtg ctgcataatc aattcctgcc ccaacatatg caacacctaa
     1141 caaaatccat tcaccgatcc aaaagaatcc catttgcaca tctacacagt ttttacttct
     1201 tgttattgca gtatggttca ataatttaat attggaagaa ttggcatttt taaaaatatc
     1261 atacttttca cataattcta caaatcttct aatatctctc tttattacag cctctcgaaa
     1321 ttccggctta caaattgcta ataaaaaacg tacagtaccg tcatcagtat ctatagagct
     1381 ttttattccc aaagaccggg catattccaa aggggcattc aaaaaggctt ccgctgcatt
     1441 tgtatcattt aaaatattat gtgataataa actcatatcg tgaatataca cctgttcctc
     1501 ctgtgataac tttttcatag aaatagcagt agtttcatca tctacaaaat tttcttctga
     1561 cgcaatagct aaattaggaa aatcatttga attatcacat gaagaaaatg aagtagcagc
     1621 tattgctgcc ccaacaccta aagttagaat tttacttttc atagttcgct ttcttttgtt
     1681 taatattata ctttaataca acctcagata tatatctgga tatattgttt ttaatatact
     1741 ctattttaga gggatcattc aacagcaata gacaggcttc acaattatgc atatcagcat
     1801 taacctcaat atttttcccg gtttccattg ctattttatt taatataaat ttcggcccat
     1861 caacataagc ccatactttt aaaaaatcat caaattgtct tgtatatatt ttatttatac
     1921 cggcagtatt catatttcca atttttaaaa acttagcttt tctacaagcc agtccacaac
     1981 aagcatacac attcccttcc ggatcaatag gaatactctc aaatagactg ttgcacccat
     2041 gggatattat aggtctctgc acatatctat gttttattaa ttcattataa tttgtatcac
     2101 gtttaatttt atcctccata tcaaatggaa tccatatacc agaagaaaag ataactttat
     2161 tatcccgtat atactctttt aactcttcat gatttttgaa atcttcctca gaaaactgtg
     2221 aacttggatt cgtttctata ttcaccaaac aaggcaaatc cactttagct gctgctctta
     2281 tagcatttac gatattatca aagggcaccc atttttgatg atcatccccc gtgcttaaat
     2341 ttaattcatt taaccccaac tcctttagta acaccaaaat tccaagagcc ttttcataac
     2401 taacagccca atacccatta gtaacaaccc ttgttataag ccccttttta tgtgcataat
     2461 aaatagcttg atataaatca tcttttaagg aaaaacattc tccaccacta aagacaacca
     2521 gcctaatcgt agggaaagct tttacacatt ccgatatata ggtttccatt tgtttaaatg
     2581 acattctccc cctacgttct tggttacact caaaacaaca attcttacac gctgccgtac
     2641 aataataagt tgtcaacaat gataaggtat taggtgatat aaaattcagt aattccatgg
     2701 ctaattattc acttaagagt ttaaactctt tcaaaatatt acttatatgg caaatatact
     2761 ttatttttgt tacagccaaa cggttaaaca cgaaatttta atctaattat acaattttat
     2821 caatgtgaat aacaacttac aaaattataa ttttattaga ttagaaagga agtagcattc
     2881 atagccctca cattctacat ttgtagaaac agattcaatc aaaacaaaaa atatataatt
     2941 attagccctc tatagacaca ctgcataagc aggaaattta gaatagcctc cagttggaat
     3001 aattaaatac ggaacagcaa gaaacaaatc ttaaataata caaaacaccc aattttactt
     3061 ttcagggtgt aaaattgggt gttattcttg taaacaactg attatcaatg tttattgcgg
     3121 agagacaggg attcgaaccc cgggtacctc gcagtacaac ggttttcaag accgccgcaa
     3181 tcgaccactc tgccacctct ccagaactac ggttaagtag tgcttttctc ttaaagcgct
     3241 gcaaaggtac gaatcatttt ttaacttgca aattattccg caaaaaaata ttagaaaagt
     3301 atatttggaa gtaataactg ctatctagct tctccccata aataggtatt tttatgctat
     3361 tcaacataaa ataggaccct tttatatacc taaaccgaaa aaaggttgta aatttgcgcg
     3421 ctctaaagga taactaacca ctaactgatt aattttatgg aactgaataa gacctttaaa
     3481 gatggacttt ggagtaaaga aatcaatgta agggatttcg ttagtaacaa catcactcct
     3541 tatgaagggg atgcttcttt cctgcaagga cctaccgaac gcaccaaagc tgtctggaat
     3601 cactgtctca aagctctcga agaagagaga aacaataatg gtattcgtgc actcgactac
     3661 acaactgtat ctactataac ctctcaccct gccggctaca tcgataaaga gaacgaactg
     3721 atcgtcggac tacagaccga tcaggtgtta aaacgtgcca tcaaaccgtt tggcggaatc
     3781 aatgtggtta tgaaagcttg ccgtgaaaac ggagtggaag tagatgacag agttaaggat
     3841 atcttcactc actatcgcaa gactcacaat gatggggtat tcgatgtgta taccgaagaa
     3901 attcgttcgt tccgttcatt gggattcctt accggacttc ccgacaacta tgcacgcgga
     3961 cgtatcatcg gtgattatcg ccgcctggct ctctatggtc ttgaccgtct gatagaagct
     4021 aaaaaagaag atctgcataa tctgacaggt cctatgactg aagcccgcat tcgtcttcgc
     4081 gaagaagtag ccgagcaaat caaggccctg aaagagatta aagtattggg cgaatattat
     4141 ggtttggatc tgagccgacc ggcatatacc gcacaggaag ctgtacaatg ggtgtatatg
     4201 gcttatctgg ctgccgtaaa agagcaggat ggtgctgcca tgtcactggg taatgtatct
     4261 tcattcctcg acatctatct tgaatatgaa ttaagccagg gtacgataac cgaaacattc
     4321 gctcaggaac tgatcgacca attcgttatc aaactccgta tggtacgcca cttgcgtatg
     4381 cagtcgtaca acgatatttt tgcgggtgat cccacatggg tgaccgaatc tatcggtgga
     4441 cgtttcaatg atggacgtac caaagttact aaaacttctt tccgcttctt gcagacactt
     4501 tataacttag gcccgtcacc ggaacctaac atgactgtac tatggagccc tgagttgccc
     4561 gaaggtttca aagcattctg tgcacaagta tctatcgaca cttcttccgt acaatacgaa
     4621 aacgacgacc tgatgcgtga agtccgtcaa tcggatgact acggaatcgc ttgttgtgtt
     4681 tcatatcagg aaatcggaaa gcagattcag ttcttcggcg cacgtgccaa ccttgccaaa
     4741 gccctgctac tggctatcaa cggaggacgt tgcgaaaata caggtacagt tatggtaaaa
     4801 gacatccctg tattgaccgg tgaaacactg aagttcgaag aagtaatggc caactataag
     4861 aaagtattga tacaaattgc acgtgtatac aacgaagcaa tgaatatcat acattacatg
     4921 cacgataagt attactacga aaaggcacag atggctttcg tggaaactga tccccgcatt
     4981 aacctcgctt atggtgtagc cggactttca atcgccatcg attcactgtc cgccatcaaa
     5041 tatgcacatg tgaaagcccg tcgcaacgac atcggactga cggagggatt cgatatcgaa
     5101 ggtgctttcc cttgtttcgg taatgacgat gaccgtgtag accacctggg tgtagacctg
     5161 gtatatttct ttagcgaaga attaaagaaa ctccccgtat ataagaatgc ccgtcctacc
     5221 ctctcgctgc tgactatcac ttcgaacgta atgtatggca agaagaccgg tgccactcct
     5281 gacggacgcg ccaaaggcat tgcctttgct cccggtgcca accccatgca cggacgtgat
     5341 aaaaatggtg caatcgcctc actgagttct gtagccaagt tgcgttatcg cgactcacag
     5401 gatggtatca gcaatacatt ctcgatcgtt cccaaatcat tgggagcaac acaagaggac
     5461 cgtatcgaca atctggtgac catgatggac ggatatttta caaaaggcgc acaccacctg
     5521 aacgtaaacg tgctgaaccg ggaaatgttg caggatgcga tggaacatcc cgaaaagtat
     5581 ccgcaactga ctatccgtgt ctcaggatat gccgttaatt tcgtgaaatt gagccgcgaa
     5641 catcagttgg aagtaatcag ccgcagtttc cacgaaagaa tgtaattgaa tgataaacgt
     5701 acactcatac gagtcaatgg gaacattcga cgggccgggt ctccggctcg tcgttttcct
     5761 tcaagggtgt aacttccgtt gcctctattg tgccaatccg gacacaattg aagccaaagg
     5821 agggacagca accgatcctg aggaaatagt tcgcatggcc gtcagtcaga aagctttctt
     5881 cggtaaaaag ggaggtatca ccttttccgg cggagagcct acttttcaag caaaatcgct
     5941 tatcccactt tttaaaagac taaaggaagc aggaatccat atttgccttg ataccaatgg
     6001 cgggctatgg aacaatgatg tagaggaact attggaattg actgatctgg ttttattaga
     6061 tatcaaagaa tttaatccgg aacatcatca gtctttaacc ggaagaagca acgagcagac
     6121 cctgaaaacc gcagcctggc ttgaaaccaa tcataaacca ttctggttgc gatacgtatt
     6181 agtgcccggc tacagtgact tcgaagacga tatccggcag ctgggagagc atcttggaac
     6241 gtaccagatg attcagcgtg tagaaatatt gccttaccac accttgggcg ttcacaaata
     6301 tgaagcaatg aacaaagaat atatgctgaa aggagtgaaa gagaatactc cggagcagat
     6361 agaaaaggct gagaaactat tcaggcaata cttccggacc gtacaagtga attgacttat
     6421 ataagtgtcg aaattcgtat tcgccacaga ttacacgaat ttacacagat aaagattcat
     6481 tggcaatcaa cagattaagt tcattctgcg gtgaattatg acgactgcac ttatttataa
     6541 ttttgtaagt cacgatataa aagtctccct gttcttgcct taattcatta caatacaagg
     6601 caagaacagg gagataatgt aaccggcata ttttttgcca ccctacttta ataagtgaat
     6661 cgcaatcctg cctgcaagtt aaagttacaa ggcctttctt ttcggatggt ttgtactttg
     6721 gagccatcat caaagaaata cgaaactccc ggttccacat ataggccgac atgatctgtc
     6781 gcattgaatt gcgctcccac gacaccggct acagaaaatt gcaaaggctt cacattcacc
     6841 ttatcatccg ccaactttcc ataaacacac ttttcaacca ttcctccggc agatacatag
     6901 agtgtaaaat atttcttttc cagaaaattc cagtttccac gtacaggaat acctatataa
     6961 tgcaatttct gactctgcat cttggtatcc ccctgccgtt tgatgtcaga agacaacaac
     7021 gtataagtca atcccgtctc tacagagaaa cctttgggaa gagacttacg tacagacagt
     7081 ccgaagctaa ccggctgatg atgttcataa tccaccacgg cagttgtatt ggacttcagg
     7141 taagggactc cttcttcaaa tataacttcc tgatcggcag gaatactcac agctccattc
     7201 atgatcgtca tcaagtcgac cctgttagtc atcggacggg gcgcaaaatt ttcggaacca
     7261 tttgtcggaa gtccacctcc attaccgata cccactccca tcgaccattt accaccacgt
     7321 ttagcagaag agtctccgat aggcaactga tacttgtctt taccggacgg tcgccgcgct
     7381 tctttcctct ttggaggctg cgctgtcaca ctttcttttt tctcgattgc cgcagttgct
     7441 tcctgttgcg gctcagctct cttttcctcc gtcactgcct ccggttgctt ctctgccagg
     7501 gaggatacct ccggaacaat caccggatca gtattctttg ccaaatagcc cgaaacaggg
     7561 ttaatactcg tcgttcctac cggcttaacg ggttcggata cagctacctg tacatccggc
     7621 aaggcaggtt ccggcaatac atccgggttg acagccagtg aaggagccgt tgcataacgg
     7681 atttcatcag ctaccggact attcagaaaa tacaaactga cagcagtcgt taccaccaat
     7741 accacagctg ccgcagcaac cgcccaccgg cgatacggat atattcgttt ttcggttaca
     7801 ggcatcagtt ccctttccag tcgttcccaa ccggaagcag gcatcggctc cgaataatct
     7861 tcgagcttat ccttgaatgc tttaatccat ttttcgtctt ctttcatcat tctatttcat
     7921 ttttgaaatc caaggttcac ctcagtatct gtaaatacat gtcaaccatt ggtcaccaac
     7981 cattctttca ctttctttgc caatacactt tttgcgcgaa aaagctgtga ggcagaagat
     8041 ttttcattaa tccccaacat ctgtgcgatt tccttgtgcg acttatcttc aaaggtgtat
     8101 aaattgaata cggtacgata tccggcgggg agttcattaa taaattgcat cagcactttc
     8161 tgtggtattg cttcaacagc cgaagcatcc ggttcttcat acgtttcggg aacttcatcc
     8221 agtgccgtgg tctggttcat cacgtcgttc tttcttaaga actgtaaagc cgtattcacc
     8281 attacacgct ccatccatgc tctcagagag ccttcacccc gccaggtaaa cttgtcgaag
     8341 gagtcgaaaa tcttcaggaa accgtcgtgt accaagtctt gtgccatgtc cctgtctccg
     8401 gcataacgaa gacagacacc aagcatgcgc cctgcgtact gctcataaag ttctttgcgg
     8461 gcacgattat ctccctgcct gcaacgttcc gacagctcta attcattcat tctcctaaac
     8521 acgtgtttac cttataaatg cagcaaagat agaaatactg cacagagaga acaactcttt
     8581 tatcactttt gtttctttaa cattttagga tgcaatattt catcacttcc tgcattttct
     8641 caatacaata aagaataaat ctcaatggat aaataggata aaaccaacaa gaaacttatg
     8701 aagaaattta atttaataac ttttgccgtc atcctgatgt tattgcccat tttacagtca
     8761 tgtctggacg atgccaacaa cgacgagtgg gtcacttgtc ctccgggtgg aatattggcc
     8821 atcggcacaa tgaagattcc caatgcggac actccaaggg actttttcat tgcgttggac
     8881 aatggagaca atgtacttcc ggcagatacg gccgatatac gcaacaggaa atacactgtt
     8941 gcagaaggtc aaagagtctt cgttggctat ctgcagatgg gagaagagaa acccggatat
     9001 gagaacggta aaatattcac gatagaagat atattgacga aagagatcat cccactgacg
     9061 gaagctacag cagacagcat tggagacgac cgtatcaacg tcacagcgca tgcacttacg
     9121 aaagattatc tgaccatcga atatcaatat ctgggcagca tgaatgaaaa taaaaaacac
     9181 atgctgaact tggtacaaaa cgaaataaca ggtcccataa aagatgacgg atatatctat
     9241 ctggagttcc ggcataatgc ctttaatgac tcccccaatc aattgggttc gagccttgtt
     9301 tctttcaagc tggatagtat agccgagcaa ttggcgacag ccaaaggaat aaaactccgt
     9361 gtgaacacca tttatgacaa tatacagtat gtcacaatag atatcaacga agacaaaaac
     9421 ttaaaaataa aatcatttca ttctcaataa aacaacaaga aacacctaca caatcaggca
     9481 aaacgagtaa taattctgat acataaaaga aataaggcgg cgatgtttgt gaaaatatcg
     9541 ccgtcgtttt tatattatac cagacactga acggcctgca gggtaagcat ctccttggga
     9601 accgccgcct gaatctcctc tttcaaaacc tgcagcagac tggtgcggat gaagtctttc
     9661 cgggtcacca ggacaatctg acgggtaggc cgcgggatag caaacggacg gaccagttct
     9721 ttctgctctt cgctcaattg catcactgcc agttcgggaa taaacgtaat ccccttacca
     9781 ctctccacca tatgcataaa ggtttccata ctacccagcc gatacgccat ttggctgatc
     9841 ttaaccgctt ccatctgaca aaaacgaacc aactgatcgc ggaagcaatg cccttcgtca
     9901 agaagccaaa gccgttcccc tgtcacatcg gacgtacgaa tcacatcgtg cttgaacaac
     9961 ggttccttct ttgagacata gcccaggaat tgctcgtaga ataaggtctc ttccgttaat
    10021 gcggcatcat ccagcatgct ggcaatgata gcagcatccg cttcaccggt cagcagagcc
    10081 ttgcgaatgt cgggcgtctt catctccatc acccgtatat caagatccgg gtatttctcc
    10141 atcagttgcg gaaagaaacg gggcagaaga taaggtgcaa tcgtcggtaa cactgccaat
    10201 cggaatgtac ccgacaggga gtgctgttct tcgctgatga tctccttgac acagataact
    10261 tccgaaagaa tcttacgggc ctgttccagc actttcttac caatggcagt agggcaaacc
    10321 ggtgtcatgc tacggtcgaa cagtttcacc cccaattcgt cttccagctt ctggatcatt
    10381 gcactcaaag taggttgcgt cacccggcaa tactcggcag ctttagcaaa atgccggaac
    10441 tggtcgacag ccagaatata ttccaattgt tgtatagtca tcgttctctg atttattaaa
    10501 gatatagaat ctatcaatgc aaagatagaa attttcagtt tgacacgaat cattttgtgc
    10561 cgtatctttg ttccagataa aaagaagaaa tatagtatta actcaaaaaa aacaatatca
    10621 ttatgaagac tttaaattat acacatttgg aagaaaaagg agctaacacc atcgtactgt
    10681 cattacagca actgcttgcc gattttcaga ttcattatgc aaacctgaga ggatttcact
    10741 ggaacatcaa aggacacggt ttcttcgtac tgcacagcaa gtttgaagat ttatataacg
    10801 gagccgccga aaaggtggac gaaatagccg aacgtatact gatgctggga ggaactcccg
    10861 ccaataaata cagtgactat ctgaagatgg cgcagatcaa ggaagtggac ggagtgaata
    10921 aggccgacga cgctctgaat catattctcg aaacttacgg gcatctgatt gcggaagaac
    10981 gtaaaatcct gtctctcgcc tcttcacaca acgacgaagt aacagtggcc atgatgagcg
    11041 actacctgaa agaacaggaa aagatggttt ggatgctgac tgcatacaac ggataacagc
    11101 cgaaagggtg tagccatctg accgaaaagg tgtagccata caagcaaaag ggtgtagcca
    11161 tcccggcggg atagctacac cctttctgtt ttattcgatt cagatgatac ttgtacgttt
    11221 ggtaaattca ataatttccg gaatgtatcc gaatgcgagc ccggtcactg tatccgcaca
    11281 cccataatag atggcaatcc gtccggtctc cgaatcatga agcgctgcgc atgggaaaca
    11341 gacattaggc acatcaccca tacattcgta atccttctga ggtgaaatca gataaggccc
    11401 cgaacggaat tttactttcc agggctgatc gatgtcaagc agtgccgaac caaaactata
    11461 cacaaaaccg ttgcaggaag ccaatacacc atgatagatc agtaaccagc cttccgaggt
    11521 ttcaattggg ataggccctg caccgatctt ggtacactgc caggcactgt cttcgaacgg
    11581 agccggcgac ataacatgac gatgacgtcc ccagaactcc atatcgggag actcgctata
    11641 gaaaatatct ccaaaaggag tatgcccatt atcactcggg cggctcaaca tcgcaaaacg
    11701 accgtttatc ttacgaggga acaagactcc attccgattg aagggaataa aggcattctc
    11761 caactggtga aaagtaacaa aatcataggt gtaggccaca ccgatagtag gaccatgata
    11821 gccattacac caggtcacat agtagcggtc ttcgataaag caaacccgtg gatcatatcc
    11881 atagacccag gttccaacct cagcgtcatc acattgaaac tttaacggtt cttcgttgat
    11941 atcccaatga acagcatcct tgctgaatcc cacatgcaaa cgcatgcgac gattagtatc
    12001 atcacaacgg aacacccctg catagccatc cttaaacgga actacggcac tgttgaatat
    12061 actgtttgaa gtagggagca agtcgcgcgg aataatcgga ttggccgaac aacgccacac
    12121 tacatcttta catcctgccg gacgttcttc ccaaggcata gccggcaaag cagcacctgc
    12181 aattttaatt tcttccatga ttcgattaaa ttaatattat gtatatatct tgtttatatt
    12241 gaaaatctct ttttatttct tctttccgtc cggatatgtg aaaggtacca gccaagtcac
    12301 gataaaagcc ggtatggtag cgataagtac ccagataaag aaatcgcgat aacccagcca
    12361 atcgctcagg tatccgctca tcattccggg aagcatcacc cccagattca taataccggt
    12421 agcaaaagca taatgtgcca tctgatgttt gccgggagcc acttgctgca tcataaagag
    12481 catcaatccg acaaaaccaa acccgtaacc caagtattca gacacaatgg ccataccaat
    12541 aatccataga tcggaaggct ggtaaagggc taacaggaaa tataccaaga acggaatatt
    12601 aaaagcgcaa cataaagaaa acaaagtctt ccgaagtccg aaagccgaaa tgtaataacc
    12661 ggccaaaagc gaaccgagaa taaaagctcc cgctccgaac gtaccatata ccaagccgat
    12721 atcctgagtg ctgagtccca atccaccatc cgcaaccgac gctttcagga acaacggtac
    12781 aatcttgatg gcatatcctt cggcaaaccg gtacaaaatg ataaagacaa tgtagaaagc
    12841 aatatgtttt ttttggaaaa aagagcggat gacttcccaa agcatattca atgcgtcact
    12901 catcgtattc acttcaccgg aagcgcctcc tcccgaaggc aaaatccgga tgtggtaaag
    12961 accgatcaga atcataatac ccgcacacat caacatgaca atcatccagg catgtaccac
    13021 tccaaattca tccttcagca tacctgccag ccaaaccaag cctccgttgg caagtatctt
    13081 ggccagatta taaaaagctc cctgccaacc gatatacttg gcttgctggg tagcagtcag
    13141 ttcagtcagg tatactccgt cacccgcaat gtcatgagtc gcaccactga gagcaatgat
    13201 ccccatcaga gcgatggcat aacgaaaaaa gtcgggcagc ggcagcgaaa gtgctaccaa
    13261 tgcaaatgcc agtccggtaa tgatttccgt agcgacaaca aagtattttt tcgttttaaa
    13321 catttccaga aacggactcc ataaaggctt caatgtccag ggaagcataa taagagaagt
    13381 ccagaaagca atctgtgcat tcgacacttc catatcggaa aacataagga cagaaaccat
    13441 cgaaagggcc acaaacggca atcccatagc aaagtaaaca gtaggcaccc aacatacagg
    13501 gcttatcggc tttttattca tcagttagtt ttttataata attccatcgg ttaacaattc
    13561 cagtaagcaa agatagggga tattaaaaac ataacccaag attacgacaa gaagttgctt
    13621 tcattattta ataatacaac tcacccggga aaactactaa cctctatcac ccttttttta
    13681 ttaaacttta tcaatacaat acacgcaaag aagcaccgaa gactttcatc cccgatgcct
    13741 ctcgccccct tatctacaat ctaaacacct ctattgcttc acatataaat ttatctcagc
    13801 aaacccggta taattatccg gagtcagaca gtttattctg aattccttta cattcgggat
    13861 aggtggttcg atggccgcat attgcggatc agccccttta aaatttctga aagtcaagac
    13921 tctcgggtaa gtaacccact cggtttcacc ctctttccga accttaatct cagcacttct
    13981 caggttataa cccgatccgt aggcactctg tttagtgacc gaaaatccgg ttaaggtaac
    14041 aggccggtcc agtaccgtat tccaccaaca ctctccggca ttagccactc cccatgtaaa
    14101 ccaagtagta tttatctcac cgtcaatagc cagatgtgca ccatatttgg catcatcatc
    14161 ggcataaaca ttactgcaac ttacactcca cgcacttcga tctacagcgg accaattccc
    14221 gggtttcgta taactggtat aaagcacgct ggtataaatc cggatataaa ccgtcttcat
    14281 agatgtactg acagcctgtt cgtccatgcc cgtaactcct ttaagcgtca cgggaagcac
    14341 atatccgtca ggattagtca acttttctat attcttcaaa acgacctgaa aagatgaatc
    14401 ggccactgtc tgtcccgttt ttaagacaac ttcacttgtt tcaatggtat aattatcttg
    14461 gggcaacaac ttacatttcg tcttattggc agaattgtaa gtatccactt tcagcgtatc
    14521 tactcccaaa gcggcagtga catcccgcgt aaccggctgt acggcacaca attgtatttc
    14581 aaaatcagaa cggtcagcag tagaggaatt gctcacacaa tccaccacta ccgcagcacc
    14641 catttcggcc cccggtgcaa ctcccgttct gatatatatc ttttgatatt tgtccatttc
    14701 atcatcatcg ttgctgcacg aagccaacga tacaaagcct gttatcaggc agattaaggt
    14761 cacaaaattc aaatgtctat tcatatctta tcttcttttt acatagttat tgcttatcaa
    14821 aacgaacatg ctctttccag acaagagttc ctcctgccac caaatcgtat ccgtgtccgg
    14881 tacagtcggc aaaggcattt cccttacctt catccatttt ccaatagcct atcaggttcg
    14941 gatcggcggg tttcacggca aaatacatgt tggactgaat ttgcgtctgg ctgattgcgc
    15001 tcttccaaag acgcacctgg gccatctgac aattgttgcg gaagtaacta ccgctcgaaa
    15061 ccatgttcat cttgtcgaat cttaccgggc caccctttgt ctgcagagtc acgtcgagca
    15121 ctccgttgat ataaatcgac aataacccgg aagaattata aacgaaggcc agatgatacc
    15181 acttattctt ctcaaacaaa gtcaccgtat tgacctgact tccaagtgtc ttcacctgta
    15241 atgaattata agggatcata gcgtcaccga aacggatata aacctcgtgg tcgctgctgc
    15301 ccgaattaaa tatagcctga ttattaatat cgaatccgtc catctgtacc caagcctcga
    15361 gtgaccattc attggttgtc actccccaca attcgtcctt ggcgggcttc acggcattgg
    15421 tcgtattcat aaacggtaca gactgtatca gcggcttatc cagcaaaatg ataaacttcg
    15481 acgaaagccc gattgtagac accggtccct gaatttctgt gagagatacc ggaatagcat
    15541 acaattctcc gttctcgttt gaataaggtt tcactctaaa ctcactgggg attgcgctaa
    15601 catcgcctgc cgctatcttt atctctttgt cataagtaaa atactgctcg ggaaggactt
    15661 cgtacgaagt ttcattagct tcattgtact ctttaagaat agaaggatct accgtcagga
    15721 cagcagtcac attttcggtt acaggctgtc ccacacgtac ggtcagagta gttgttgtta
    15781 cattttcagg atcaacggta acctttgccg aaccattctc ggatgcttca ttcaaataaa
    15841 tcgcattgtc gataacctgg taatcggcat cgttgcatcc tgccaggatc atcggcagaa
    15901 cgaaacaggc aaacaaacat tgttttattg ttattctttt cataatcaaa ttctttaaag
    15961 tcattttaca gcaggattca ttattctgat tgcttcacgc aggtacttat attcgatgtc
    16021 gcccggatag tcatattcca tgtgataggt gcctactcca cccttccgta cctgttttcc
    16081 gtcaatagtc ggagtccagc gtgccatgcc ggcaagtgct ctcattttgt ttccgtaacg
    16141 atctacataa tcacctcctc ctgtcggagc ataagattcg aaattctccg taacgatgta
    16201 catattagcc actttctccg gaggaagtat tcctttaaag ttggcaatcg taccagccag
    16261 acgtctgtca agattagcgt cggaattacc cgcaaggtta gagtatgcct gcacaatgaa
    16321 atagtcaaag taaggcccgg tttccggatg aatactttga ggctcgccat caatcacaag
    16381 taaccgtccc gtacccgatt taggtccgat tcttt
//
