LOCUS       c00100_gnlPro..        14860 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CJMDCIDA_100.
ACCESSION   c00100_gnlPro..
VERSION     c00100_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 17:27:33
            Original ID  :: gnl|Prokka|CJMDCIDA_100
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14860
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14860
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2:14420]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3..14420
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14860
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14860
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             3..1145
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg100_1"
                     /sec_met_domain="CT_Btheta (E-value: 2.1e-223, bitscore:
                     731.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="EGINALAGYAEIFQRNILASGVIPQISGIFGPCAGGAVYSPALTD
                     FTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHSTKSGVTHFTAKTEEEGLALI
                     RTLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDSPNKPYDMYEVISAIVDNGEFL
                     EIQKDYAKNIIIGFARFNGQSVGIVANQPKFLAGVLDSNASRKGARFVRFCDAFNIPIV
                     SLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTITLRKSYGGSHIVMSCKQLR
                     GDMNYAWPTAEIAVMGGAGAVEVLYAREAKDQENPAQFLAEKEAEYTKLFANPYNAAKY
                     GYIDDVIEPRNTRFRVIRALQQLQTKKLSNPAKKHGNIPL"
     CDS             1177..2097
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg100_2"
                     /sec_met_domain="OAD_gamma (E-value: 3.3e-15, bitscore:
                     46.2, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLLLLIGLTSCGEQKSNNKLLLNEVLIDNQNNFQD
                     DYGLHSAWIEIFNKSYGSADLAACLLKVSSQPGDTVTYFIPKGDILTLVKPRQHALFWA
                     DGEPNRGTFHTSFKLNPETANWVGLFDSGRKLLDQVVIPAGTLGPNQSYARISDGAADW
                     EVKGGSKDKYVTPSTNNKTLDSNAKMEKFEEHDSVGIGMSISAMSVVFCGLILLFIAFK
                     VVGKVAVNLSKRNAMKAKGIDKVEAKELSQAPGEVYAAISMALHEMQDEVHDVEETVLT
                     ITRVKRSYSPWSSKIYTLRENPNRK"
     CDS             2122..2556
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 66.7; E-value:
                     4e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg100_3"
                     /sec_met_domain="Biotin_lipoyl (E-value: 7.8e-22, bitscore:
                     66.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNSYKVTIGDIEDNIAHVEVNGTHYKVEMEKQPKTA
                     PKPVVVRPMPNSPAAPTTPVVKPAAPSTGKSGVKSPLPGVILDIKVNVGDTVKRGQTII
                     ILEAMKMENNINADKDGKVTAINVNKGDSVLEGNDLVIIE"
     CDS             2558..3718
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg100_4"
                     /sec_met_domain="OAD_beta (E-value: 1.8e-154, bitscore:
                     503.5, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFINFLGNNLADFWTYTGFANATVGHIVMILVGLFFIYLAVAK
                     EFEPMLLIPIGFGILIGNIPFNMDAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALEMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKHERVIRMKPPRAVSHTEKVIFP
                     IIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDVITILLGLTVGAS
                     TQASEFLTLDSIKIFALGALSFIIATASGVIFVKIFNLFLKKGNKINPLIGNAGVSAVP
                     DSARISQVVGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             3932..5266
                     /locus_tag="ctg100_5"
                     /transl_table=11
                     /translation="MKRIILLAFLCTTTLVMAQRINHVQEAIANYDYEAALTLIAKEKP
                     TIPLLLQKGKAQRGLGMNTEALSTYQEIITNDTANTRAYIEAAECCRSLAKYQQALKYY
                     EQALDLNPENKYVRIQYIGLLLSLQKFQDALGESSLMTEKDSSAIALHLQAQSFEGMGE
                     LLPATGCYYNIQEKYPDDYLAAAKLAALNIAGSYFNEAIEATEKYRQIDTTNIAVNRQN
                     ALAYCLNKDYPTAIQRYEYLVSQGDSSFHTCYYLGISYYAEEKYYEAHDFLEAARKHDP
                     ENVNLLYYLGRACAKTSWKKLGVEYLEKALDLTIPKDSNMVRLYIGMTDCYKMAQMPKE
                     QIESIRERYRKYDKQNHKLLYDMAFIYFYSLKDKKNTERCLEAFLKTRPKEDKEEEAKL
                     NERGELVLGTKNYYNAAANWLKDIQSKQKIEDFFLGGNVPAQKPE"
     CDS             complement(5346..6350)
                     /locus_tag="ctg100_6"
                     /transl_table=11
                     /translation="MVNYKDLGLVNTRDMFAKAIKGGYAIPAFNFNNMEQMQAIIKAAV
                     ETKSPVILQVSKGARQYANATLLRYMAQGAVEYAKELGCAHPEIVLHLDHGDTFETCKS
                     CIDSGFSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELGVLAGVEDEVSSDHHT
                     YTDPEEVIDFATRTGCDSLAISIGTSHGAYKFTPEQCHIDPATGRMVPPPLAFEVLDAV
                     MEKLPGFPIVLHGSSSVPEEEVETINKYGGALKAAIGIPEEELRKAAKSAVCKINIDSD
                     SRLAMTAAIRKTFAEKPAEFDPRKYLGPARDNMEKLYKHKILNVLGSDNKLAE"
     CDS             6773..7027
                     /locus_tag="ctg100_7"
                     /transl_table=11
                     /translation="MKKGLHPESYRPVVFKDMSNGDMFLSRSTVATKETIEFEGETYPL
                     LKIEISNTSHPFYTGKSTLVDTAGRVDKFMSRYGDRKKK"
     CDS             7673..8725
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Biotin_lipoyl_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg100_8"
                     /sec_met_domain="Biotin_lipoyl_2 (E-value: 1.4e-12,
                     bitscore: 37.1, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNIYVIALAAILFQGCGQKKEMTAPATRPVKTTIVESRSVIRKD
                     FSGIVEAVEYVKLAFRVSGQIISLPVIEGEKVKKGQLIAAIDPRDIALQYAATKSAYET
                     ASAQVERNKRLLSRQAISVQEYEISLSNYQKAKSEYELSSNNMRDTKLTAPFDGSIEKR
                     LVENYQRVNSGEGIVQLVNTQNLRIKFTIPDAYLYLLRAKDPRFLVEFDTFKGHVFKAR
                     LEEYLDISTEGTGIPVSITIDDPSFDRDLYAVKPGFTCSIRFTADVGPLVQDSWTIIPL
                     SAVFGESDGNNMYVWVVEDNKVHKRKIVVNAPTGEAQVLVSEGLKPGEQIVIAGVYQLV
                     EGESIKSIDK"
     CDS             8722..11760
                     /locus_tag="ctg100_9"
                     /transl_table=11
                     /translation="MNLAKYSLDNTKIIYFFLAVLLIGGITSFGKLGKKEDAPFVIKSA
                     VIMTRYPGAEPAEVERLITEPISREIQSMSGVYKIKSESMYGLSKITFELQPSLSASSI
                     PQKWDELRRKVLNIQPQLPSGASTPTVSDDFGDVFGIYYGLTADDGFTYEEMRNWAERI
                     KTQVVTADGVMKVALFGVQTEVVNIFVSTNKLVGMGIDPKQLANLLQSQNQIINTGEIR
                     AGVQQLRVTANGMYANIDDIRNQVITTKAGQVKLGDIAVIEKGYLDPPSNIMHVNGKRA
                     IGIGVSTDPQRDVVQTGENVKVKLNELLPLMPVGLELQSLYLENEIANEANNGFIINLI
                     ESILIVIVIIMLVMGLRAGLLIGSSLIFSIGGTLLIMSFFGVGLNRTSLAGFIIAMGML
                     VDNAIVVTDNAQIAIARGVNRRKALIDGATGPQWGLLGATFIAICSFLPLYLAPSSVAE
                     IVKPLFVVLAISLGLSWVLALTQTTVFGNFILKAKTGDSTKDPYDKPFYHKFASVLGVL
                     IRKKAVTLVSMVILFIISLIIMGTMPQNFFPSLDKPYFRADVFYPDGYSINDVVKEMKS
                     VEEHLAKQPEVKKVSITFGSTPLRYYLASTSVGPKPNFANVLVELTDSKYTKEYEENFD
                     GYMKANYPSAITRTSLFKLSPAVDAAIEIGFIGPNVDTLVSLTNQAIAIMHQNPDLINI
                     RNSWGNKIPVWKPVYSPERAQPLGVSRQGMAQSIQIGTTGMTLGEYRQGDQVLPILLKN
                     NQLDSFRINDLRTLPVFGTGNETTSLEQVVSEFDFQYRFSNVKDYNRQMVMMAQCDPRR
                     GANAISAFNQVWSQVQQEIKIPEGYTMKYFGEQESQVESNEALAKNLPLTFFLMFVTLL
                     FLFKTYRKPTVILLMLPLIFIGIVLGLLVLGKSFDFFSILGLLGLIGMNIKNAIVLVDQ
                     IDLETAAGKKPLDAVISATTSRIIPVAMASGTTILGMLPLLFDAMFGGMAATIMGGLLV
                     ASALTLFVLPVAYCAIHRIKGEQ"
     CDS             11774..13069
                     /locus_tag="ctg100_10"
                     /transl_table=11
                     /translation="MKRLSMKEMKTQLILFSLLLLGSTAWAQQPCLSQEAYREKVEAYS
                     QILKQQKLKTLASSEARKIAHTGFLPKIDVNADGTLNMSDLSAWNEPVGEYRNHTYQGV
                     FVVSQPLYTGGALNAQHQIAKADEKLNQLNEELTLDQIHYQSDAVYWNASASKAMLQAA
                     DKYQSIVKQQYDIIQDRFDDGMISRTDLLMISTRLKEAELQYIKARQNYTLALQQLNIL
                     MGEAPNTPVDSLYNIGMISAPVRILPLEDVLQRRADYASTEVNIMKSQAQRKAALSQFN
                     PQLNMYFSGGWATATPNLGYDVSFNPIVGVNLNIPIFRWGARFKTNRQQKAYIGIQKLQ
                     QSYMTDNINEELSAALTKLTETESQVKTAKENMSLANENLDLATFSYNEGKASMVDVLS
                     AQLSWTQAHTNLINAYLAEKMAVAEYKKVTSE"
     CDS             complement(13185..14420)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg100_11"
                     /sec_met_domain="OAD_beta (E-value: 1.6e-143, bitscore:
                     467.5, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNEIFENLYDMTAFSNIIAEPQFLIMYAIAFVLLYLGIKKQYEPL
                     LLVPIAFGVLLANFPGGDMGVIQADENGMVMINGVMKNIWEMPLHDIAHELGIMNFIYY
                     MLIKTGFLPPIIFMGVGALTDFGPMLRNLHLSIFGAAAQLGIFTVLLVAILMGFTPQEA
                     ASLGIIGGADGPTAIFTTIKLAPHLLGPIAIAAYSYMALVPVIIPLVVKLFCTKKELSI
                     NMKEQEKKYPSKTEIKNLRVLKIIFPIVVTTVVALFVPSAVPLIGMLMFGNLVKEIGSN
                     TFRLFDAASNSIMNAATIFLGLSVGATMTAEAFLNWTTIGIVIGGFLAFALSITGGIFF
                     VKLVNLFSKKKINPLIGATGLSAVPMASRVANEIALKYDPKNHVLQYCMASNISGVIGS
                     AVAAGVLISFLA"
     CDS             complement(14420..14860)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 63.5; E-value:
                     4.2e-20)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg100_12"
                     /sec_met_domain="Biotin_lipoyl (E-value: 8.2e-21, bitscore:
                     63.5, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="QYEAYKSGKAKEDFLADVAKRRAEKDKSPEEDAKPKTLTVQVDGQ
                     AYRVTVAYGDAELPAAPAAAAPAGEGKDVLSPLEGKFFLVKNAQESALKVGDAVKEGDV
                     LCYVEAMKTYNAIRAEFSGTITAICANPGDTVSEDDVLMKIG"
ORIGIN
        1 aggaaggtat taacgctttg gcaggttacg cagaaatctt ccagcgcaat atcctcgctt
       61 cgggtgtcat tccgcagatt tccggtatct tcgggccttg tgccggcggt gctgtttatt
      121 ctccggcact gacagacttc acactgatga tggaaggtac ttcttatatg ttccttacag
      181 gtccgaaagt agtgaaaact gtaaccggtg aagacgtaag ccaggaaaac ctcggcggag
      241 caagcgttca ctctaccaaa tcgggtgtta ctcatttcac tgccaaaaca gaagaagaag
      301 gtctggcatt gatccgcaca cttctgagct atattcctca aaacaacctc gaagaagctc
      361 catacgtgga ttgcacagat ccgatcgacc gtctggaaga ttctctgaac gatattatcc
      421 ccgacagccc caacaaaccg tatgatatgt acgaggttat cagcgctatc gtagacaacg
      481 gcgaattcct ggaaatccag aaagactatg ccaagaatat cattatcggt tttgcccgtt
      541 tcaacggtca gtctgtaggt attgtagcca atcagcctaa attccttgcc ggtgtactcg
      601 acagcaacgc atctcgcaaa ggcgcacgtt tcgttcgttt ctgcgatgct ttcaatatcc
      661 ctatcgtgtc gttggtagac gtaccgggat tccttccggg aacaggtcag gaatacaatg
      721 gcgtcatcct tcatggtgcc aaactgctgt atgcttacgg tgaagctacc gtacctaaag
      781 taacaatcac attgcgtaaa tcttacggtg gttctcacat cgtgatgagt tgtaaacaac
      841 ttcgtggtga catgaactat gcttggccaa cagctgaaat cgctgtaatg ggtggtgcag
      901 gtgcagtaga agtattgtac gcgcgtgaag ccaaagacca ggaaaatccg gctcagttcc
      961 ttgccgaaaa agaagcagaa tatacaaaac tgtttgccaa tccttataat gcagctaagt
     1021 atggttacat cgatgatgtc atcgaacccc gtaacacacg tttccgcgtg atccgtgctt
     1081 tgcagcagtt gcagactaag aaactgtcta acccggcgaa gaaacatggt aatattccgt
     1141 tgtaatccaa cttttcacat taaaacaaga acgattatga acaaaaccaa aatcggaata
     1201 ttcctttctc tgctgttgct gattggattg acttcctgcg gagagcaaaa gtcgaacaat
     1261 aagctattgc tgaatgaagt cctgatagac aatcaaaaca actttcagga tgactacggc
     1321 ttgcacagtg catggattga aatattcaac aaatcatacg gtagcgcaga cttagcagct
     1381 tgtttattga aagtaagcag ccagccgggc gatacagtaa cctattttat cccgaaaggt
     1441 gacatactta cattagtaaa gccacgccaa catgcgttat tttgggcaga tggcgaacct
     1501 aatcgtggaa ccttccatac cagcttcaaa ctgaaccccg aaacagccaa ttgggtcggt
     1561 ctttttgatt caggcagaaa gctactggat caagttgtca taccagcagg aactttaggt
     1621 cccaaccagt cttatgcacg cataagtgac ggagcagcag actgggaagt aaaaggcgga
     1681 agcaaagaca aatacgtaac cccgagcacg aacaacaaaa cccttgacag taatgccaag
     1741 atggaaaagt tcgaagaaca tgactcagtc ggtatcggta tgtctatttc agccatgagc
     1801 gtagtattct gcggattgat tcttctcttc attgccttca aggtggtagg taaagttgct
     1861 gtcaacctga gcaaacgcaa tgcgatgaag gctaaaggca tcgataaagt cgaagcgaaa
     1921 gagctttcac aggctccggg tgaagtttat gctgctattt caatggcatt acacgaaatg
     1981 caggatgagg tacacgacgt agaagaaacg gtgctgacca tcactcgtgt gaaacgcagt
     2041 tattcaccgt ggagttcgaa gatttacacc ttgcgtgaaa atcctaacag aaagtaaatc
     2101 attccctaaa aagataaaac gatgaaagaa tataaatata aaatcaacgg taactcatat
     2161 aaagtaacca tcggagatat tgaagataat atcgctcatg tagaagtgaa cggtacgcac
     2221 tacaaagtag aaatggagaa acaaccgaaa actgctccca aaccggtagt agtacgtcct
     2281 atgcctaact caccggctgc tcctaccaca ccggtagtaa aaccggctgc tccttctaca
     2341 ggcaaatcag gcgttaagtc cccgctacca ggcgttatcc ttgacatcaa agtaaatgta
     2401 ggtgatacag tgaaaagagg acagactatc attatattgg aagccatgaa gatggaaaac
     2461 aatatcaatg cagacaaaga cggcaaagtg actgctatca atgtcaacaa gggagattct
     2521 gttcttgaag gtaatgacct cgtaattatt gaataatatg ggagatttta ttaacttttt
     2581 aggaaataac cttgccgact tctggaccta cacgggattt gccaacgcga cagttggtca
     2641 tatcgtgatg atcctcgttg gcttgttctt catctatttg gctgtagcca aagagttcga
     2701 gccgatgttg ttaattccta tcggattcgg tatcctgatc ggtaatatac ccttcaatat
     2761 ggacgccgga ctaaaagtcg gtatatatga agaaggttct gtattgaaca tattgtatca
     2821 gggagtaacg tccggctggt atccaccgct catcttctta ggtatcggtg ccatgacaga
     2881 cttctcggcg ctgatctcca atccgaagct gatgctgatc ggtgcagctg cccagtttgg
     2941 tatcttcggt gcatacatga tcgcattgga aatgggattt gacccgatgc aggccggtgc
     3001 tatcggtatc atcggtggag cagatggtcc gacggctatc ttcctttcgt ccaagctggc
     3061 acctaactta atgggagcca ttgcggtatc cgcctactct tatatggcgt tagttccggt
     3121 gatacagccg cctatcatgc gtctgctcac caccaagcac gaacgcgtta tccgtatgaa
     3181 accgccacgt gccgtttctc atacagagaa agtgattttc ccgattatcg gtctgttgct
     3241 gacctgcttc ctggttcctt ccggtctgcc tctgctgggt atgctgttct tcggtaacct
     3301 gttgaaagaa agtggtgtaa cccgtcgtct ggctaacaca gccagcggtc cgctgattga
     3361 cgttatcact atcctgttag gtttgaccgt aggtgcctct actcaggctt ccgagttcct
     3421 gacactcgac tccatcaaga tcttcgccct cggtgcactg tcatttatca ttgctaccgc
     3481 atcaggtgtg atcttcgtta agatcttcaa cctcttcctc aagaagggca ataagatcaa
     3541 tccgttgatc ggtaatgcag gtgtatctgc cgttcccgac tctgcacgta tctcacaagt
     3601 ggttggtctg gaatatgatc ctaccaacta cttgctgatg cacgctatgg gtccgaacgt
     3661 agcaggtgta atcggttcgg ctgttgctgc cggtatcctg ttaggattct taatgtaggg
     3721 acaaggtgcc cctgtcaggt ttccattcgg aatgccggga caaaatatta ggtgcggata
     3781 ttgctgtttt agatgcaata tccgcactta tcattatgtt atcttctctt atcattccgt
     3841 taatctattc caaaaaggct acgaataatt cgtaaatacg atatttttta gcatcttgcg
     3901 tctttgttac gacacactaa aataaatatt tatgaaacgg attattctcc tcgccttcct
     3961 ttgtaccacc accctggtga tggcgcagcg catcaatcat gttcaggaag caatagcaaa
     4021 ctacgattac gaggcagctc tcactctcat tgccaaagaa aagccgacaa ttcccctact
     4081 cttgcaaaaa ggtaaagcac aacggggact tgggatgaat acagaagcac tttccactta
     4141 tcaggaaatc ataaccaatg acactgccaa tacccgtgca tatatcgaag cagccgaatg
     4201 ctgccgttca ttggctaaat accaacaggc actgaaatat tatgaacagg cacttgatct
     4261 gaatccggaa aacaaatatg tgcgtattca atacatcgga ctactgctct ctttacagaa
     4321 gtttcaggat gctttaggag aaagtagtct gatgacagag aaagacagtt ccgccatcgc
     4381 cttgcatctg caggcccaaa gtttcgaagg tatgggagag cttctccccg ccacggggtg
     4441 ctactataat atacaggaga aataccccga cgactatctt gccgccgcca agctcgccgc
     4501 actgaacata gccggttctt atttcaacga agcaattgaa gccacggaga aatatcggca
     4561 gattgatacc accaatatcg ctgtcaaccg ccagaatgca ctggcatatt gtctgaataa
     4621 ggattatcct accgctatcc agcgttatga atacctggtg agccagggcg acagttcttt
     4681 tcatacctgt tattatctgg gtatcagcta ttatgcggaa gagaaatatt acgaagcaca
     4741 tgactttctg gaagccgccc gaaaacatga tcctgaaaac gtaaacctgc tttattatct
     4801 cggccgtgcc tgcgccaaga cttcatggaa gaagttaggc gtagagtatc tcgaaaaagc
     4861 gcttgatctg actattccca aagacagtaa tatggtacgg ctctatattg gcatgaccga
     4921 ctgctacaaa atggcacaga tgcctaaaga gcagattgaa tcgatcagag aacgctaccg
     4981 gaaatacgat aaacaaaatc ataagctgct ctatgatatg gctttcattt atttctattc
     5041 gctgaaagac aagaaaaaca ccgaacgctg tctggaagca ttcttaaaaa cacgcccgaa
     5101 agaagataag gaagaagaag cgaaactaaa cgaacgaggc gaactcgttt taggcactaa
     5161 gaattattat aatgctgcag ccaactggct gaaagacatt caaagtaagc aaaagataga
     5221 agatttcttc ttgggaggaa atgtgcccgc tcagaaaccg gaataagcag ataaaggata
     5281 ttacgtaaaa aaggctgcaa ccgtcaaacg attgcagcct ttctatataa taggataatc
     5341 tgtgattatt cagccaattt gttgtctgaa cccagcacat taaggatttt gtgcttgtac
     5401 agtttttcca tgttatcacg agccggacca agatacttac gtgggtcgaa ttcagctggt
     5461 ttttcagcga aagtcttacg gatagcagca gtcatagcca gacgagagtc tgagtcgatg
     5521 ttgattttgc aaacagcaga cttagcagct ttacgcaatt cttcttcagg aataccaata
     5581 gcagctttca aagcaccacc atatttgttg atcgtttcca cttcttcttc aggaactgaa
     5641 gatgatccgt gaagtacgat agggaatccc ggaagttttt ccattacagc atccaatact
     5701 tcgaaagcca atggaggagg aaccatacga ccggtagccg gatcgatgtg gcactgttcc
     5761 ggagtaaact tgtaagcacc gtgagaagta ccgatagaga tagccaatga gtcacaacct
     5821 gtacgagtag cgaaatcgat tacttcttca gggtcagtgt atgtgtggtg gtcagaagaa
     5881 acttcatctt ctacacctgc caatacacca agttcacctt ccactgttac gtcgaactga
     5941 tgagcgtatt caacaacctt cttagtcaaa gcaacgtttt cttcataagg aagatgagaa
     6001 ccgtcgatca taactgaaga gaaacctgaa tcgatgcaag atttgcaagt ttcaaaagta
     6061 tctccgtggt caaggtgaag aacgatttca ggatgtgcgc aacctaattc ttttgcgtat
     6121 tctacagcac cctgagccat gtaacgcaac aaagtagcgt tagcatactg acgagcacct
     6181 ttagaaacct gaagaatcac aggagattta gtttcaacag cagccttgat gatagcctgc
     6241 atctgttcca tattgttgaa gttgaatgct gggatagcgt atccaccttt aatagcctta
     6301 gcaaacatgt ctcttgtgtt taccaatcct aagtctttgt aatttaccat tttgtttaaa
     6361 gtttattgtt agtgaataaa aattctacgc aaaagtaagc attatccatc gaataacgaa
     6421 catcggaaag aaaaatatag tagaaaaagg tttaaatcag actgcaaaat ttagcaggaa
     6481 tacgagtgtg acattagatt gtaatgtcca ccttgcaaac tttgggattt atgatttctg
     6541 aattctgatt gatgccttcg gatttatatc tccttattta tacctcattt ttcattcatt
     6601 taatcaccaa aatctgcata gccaatcaga aatcataaat tagaaatcag aaattttaga
     6661 aaaccttttt ctatttcaca gaaaagcatt atctttgcgc tctgaaaatg accattacac
     6721 tatttcttac caaaatagta acagaatata aattaaaaaa acagatactg aaatgaaaaa
     6781 aggccttcat ccagaatcat accgtccggt agtatttaaa gatatgtcaa atggtgacat
     6841 gtttttgtct agatcaactg tagcaactaa agaaaccatc gaattcgaag gtgaaactta
     6901 tccgttgctg aagattgaaa tctcaaacac ttctcacccg ttctatacag gtaaatctac
     6961 attggtagat actgcaggtc gtgttgataa gttcatgagc cgttacggtg accgtaagaa
     7021 gaaataattc aatctttcgt taagatgaaa aaagaggaga tttccggttg gaaatttcct
     7081 ctttttcgtt tcatagataa actaaaggac cgcaccattc ttcacagagt agtgcggtcc
     7141 gtatattaac tggctaaggg gaactattac caggtaatat aaaaatggta tagttaaggg
     7201 aatataccat accattatat tgtctgatct cctgaaaaat gatggtttat taaatagtac
     7261 tattcaggag aaatacttcc tattatatat aataatattc agcaggcaaa aaagacggtc
     7321 ctgctgaccc gttgcactac atattacagt ccacgaggga tgagatacag tgggcgcatt
     7381 aacgctccac acgggggaca gaaccgtata tctaaggaag ccacgagcat attcccacat
     7441 gctcgtagct taaattcgag aattaaattc tcatatcgca ttccgcgact gtaatactag
     7501 tgcggtgcaa aagtgggaat aatctctgat aaaatcaaca gaaaaggcat tttttatcta
     7561 taaacaatca ttttccttta atgttgatac taatttcaca tttctaatat acccgtctct
     7621 actgaacata gtcaagtatc aaattgttta cttcccaaac aatgaacgac ttatgaaaaa
     7681 tatctatgtg attgcactcg cagccatcct atttcaaggc tgcgggcaaa aaaaagagat
     7741 gacggcaccc gccacccgac ctgttaagac aactattgtc gaatcaaggt cagtaatcag
     7801 aaaagacttc tccggcattg tagaagcagt ggagtatgtc aaactggcat tccgcgtcag
     7861 cggacagatc atcagcctgc ctgttatcga aggagagaaa gtgaaaaaag ggcaactgat
     7921 tgcagctatc gatcccagag atatcgcatt gcagtatgct gccaccaagt ctgcctacga
     7981 aacggcttcc gcacaagtgg aacgcaacaa gcgcctgctc tcccggcaag cgatctccgt
     8041 gcaggagtat gaaatcagcc tttccaatta tcagaaagca aaatcggagt acgaactgtc
     8101 cagcaacaac atgcgtgaca ccaaactgac ggcccctttc gacggttcta tcgagaagcg
     8161 gctggtggag aactaccagc gtgtcaattc aggagaaggg atcgtacaac tggtcaacac
     8221 acagaacctg cgtatcaagt tcaccatacc ggatgcatat ctttatctcc tccgtgccaa
     8281 agatccccgt ttccttgtag agtttgatac cttcaagggc catgtgttca aggcgagact
     8341 ggaggaatat ctggacatat ccaccgaagg aacgggtatt ccggtcagca tcactatcga
     8401 cgacccttca ttcgaccggg acttatatgc cgtgaagccc ggcttcactt gcagcatccg
     8461 tttcacagcc gatgtaggcc cattggtgca ggatagctgg acaatcatcc cgctcagtgc
     8521 tgttttcggc gaaagtgacg gaaacaacat gtatgtctgg gtagtcgagg acaacaaggt
     8581 acacaaacgc aaaatcgtcg tcaatgcccc cacaggagag gcgcaagtac tcgtgtccga
     8641 aggactgaaa cccggagaac aaatcgtcat agcaggagta taccagttgg tagaaggaga
     8701 aagtattaaa tcaatagaca aatgaattta gcaaaatatt cactggataa cacgaagatc
     8761 atctatttct tccttgccgt actgctgatt ggaggtatta cctccttcgg aaagctgggt
     8821 aagaaagaag atgccccctt cgttatcaaa tcagcggtca tcatgacacg ctatccggga
     8881 gccgaaccgg cagaagtaga acggctgatc acagagccta tctcccgtga gatacaaagt
     8941 atgagcggcg tgtacaagat aaaatcagag tccatgtacg ggctctccaa aatcacgttc
     9001 gaactgcaac cttcactttc cgccagttcc atccctcaga aatgggacga actgcgacgc
     9061 aaagtgctca atattcagcc gcagctgccc agcggtgctt ccaccccgac cgtctccgat
     9121 gatttcggcg acgtattcgg catttattat ggactgacgg cagatgacgg cttcacctat
     9181 gaggaaatgc gcaactgggc ggaacggatc aagacgcagg ttgtcacagc agacggcgtg
     9241 atgaaagtag cgctgtttgg cgtacagacg gaagtagtca acatcttcgt ttctaccaac
     9301 aaactggtgg gaatggggat cgatcccaaa cagctggcca acctgctgca atcgcagaac
     9361 cagattatca acaccggaga aatccgtgca ggcgtacagc agttacgggt gacagccaac
     9421 ggaatgtatg ccaacataga cgatatccgc aaccaggtaa tcaccaccaa agccggacag
     9481 gtgaaactgg gcgacatagc cgtgatcgag aaaggttatc tcgaccctcc atccaacatc
     9541 atgcatgtga acgggaaacg ggctatcggc atcggtgttt ccaccgaccc gcaaagagat
     9601 gtagtgcaga cgggtgagaa cgtaaaagta aaactgaacg agctcctccc cctcatgcct
     9661 gtgggactgg aactgcaaag cctctacctc gaaaacgaga tcgccaacga agccaacaac
     9721 ggatttatca tcaacctgat cgaatccatc ctgatcgtga ttgtcatcat catgctggtg
     9781 atgggactcc gtgccggtct gctcatcggc tcttcgctga ttttctctat cggaggtaca
     9841 ctgctcatca tgtctttctt cggcgtcgga ctcaaccgaa cgtccctggc aggatttatc
     9901 atcgccatgg gtatgctggt ggacaacgcc atcgtagtga cggacaacgc ccaaatagcc
     9961 attgcccgtg gtgtaaaccg acggaaagcc ctgatagacg gagcgaccgg accacaatgg
    10021 ggcttgctcg gagcaacttt cattgccatc tgctccttcc tgccgcttta ccttgccccc
    10081 tcttccgtag cggaaatcgt aaagccgctg tttgtggtac ttgccatttc attaggactg
    10141 agctgggtac ttgccctgac acagactacc gtattcggaa atttcattct gaaagccaaa
    10201 acaggcgaca gcacgaaaga tccatacgac aagccgttct atcataagtt cgcttccgtt
    10261 ctcggagtat tgatccgcaa gaaagcagtg acactggtat ccatggtgat cctcttcatc
    10321 atctcgctca ttattatggg aacgatgccg caaaacttct tcccgtcgct cgataagcct
    10381 tatttccggg cggatgtatt ctatccggac ggatacagca tcaatgacgt agtgaaagag
    10441 atgaaatcgg tagaagagca cctggcgaag cagccggaag tgaaaaaggt atccatcaca
    10501 ttcggcagca ccccgctaag gtattacctt gcctccactt ccgtaggtcc gaaaccgaat
    10561 tttgccaatg tactcgtcga actgacagac agtaaatata cgaaagaata cgaagagaat
    10621 tttgacggat acatgaaagc caattatccg agtgcaatca cacggaccag cttgttcaaa
    10681 ctgtctcccg cagtggatgc ggctatcgaa atcggcttta tcggtccgaa tgtggatacg
    10741 cttgtatcac ttaccaatca ggcaatagcc attatgcacc agaatccgga tttaattaat
    10801 atccgcaatt cgtggggaaa caagataccc gtctggaaac cggtttacag cccggaacgg
    10861 gcacaaccgc tgggtgtatc ccgacaggga atggcacaga gcattcagat cggtaccacg
    10921 ggaatgactt tgggagaata ccggcaggga gatcaggtac ttcctatcct attgaaaaat
    10981 aaccagctgg attcattccg gatcaatgat ctgcgcacac tgcccgtatt cgggacaggc
    11041 aacgaaacga ccagcctgga acaggtagta tctgaatttg acttccagta ccggttctcg
    11101 aacgtgaaag actataaccg acagatggtg atgatggcac aatgcgaccc gcgtcgcggg
    11161 gccaatgcga tttccgcctt caaccaggta tggtctcagg tacagcaaga gataaaaata
    11221 ccggaaggat ataccatgaa gtatttcggc gaacaggaaa gtcaggtgga atcgaatgaa
    11281 gcgctggcca aaaacttacc gctgacattc ttcctgatgt ttgtgacgct gctcttcttg
    11341 ttcaagacgt atcgcaagcc gaccgtcatc ctgttaatgc tgccgctgat cttcatcggt
    11401 atcgtgctgg gactgctcgt actcggcaag tcgttcgact tcttctccat attgggtctg
    11461 ctaggtctga ttggtatgaa catcaagaac gctatcgtac tggtagacca aatcgatttg
    11521 gaaactgcag caggcaagaa accgctggac gcagtcatca gtgccacgac cagccgcatc
    11581 attccggtag cgatggcctc cggaacaacg attctgggca tgttaccgct actgttcgac
    11641 gccatgttcg gcggaatggc cgccaccatc atgggcgggc tgttagtagc ctcggcattg
    11701 acactattcg tccttcccgt agcctattgc gccatccacc ggatcaaagg agaacaataa
    11761 ttatccatta tccatgaaaa gattatccat gaaagaaatg aaaactcaac tcatactatt
    11821 ttcactgttg ctccttggct ccacagcctg ggcgcaacag ccctgcctga gtcaggaagc
    11881 ctaccgcgaa aaagtggagg cttacagcca gatattgaaa caacaaaaac taaagacatt
    11941 ggccagttcg gaggcgcgaa agatagccca tacaggtttc ctgccgaaaa tcgacgtaaa
    12001 tgcagacggt accctgaaca tgagcgacct tagcgcatgg aacgaaccgg tgggcgaata
    12061 ccgcaaccat acctaccagg gagtatttgt cgtatcacag ccactctaca caggcggtgc
    12121 gctcaatgcc caacatcaga tagcgaaggc agacgaaaag ctgaaccagc tgaacgagga
    12181 actcacgtta gaccagattc actatcaaag cgatgctgtc tactggaatg cctccgcttc
    12241 aaaagccatg ctacaagcgg ccgacaaata ccagagcatt gtcaaacagc aatatgacat
    12301 tattcaggac cgtttcgatg acggaatgat cagccgtaca gatcttctga tgatttccac
    12361 ccggctgaaa gaagcggaac tgcagtatat caaagcccgc cagaattata cattagcgct
    12421 gcaacagctg aatattctga tgggagaagc accgaatact cctgtagaca gcctgtacaa
    12481 catcggaatg atctccgctc ctgtccggat actgcctctg gaagatgttt tgcaacgacg
    12541 tgccgattat gccagtacgg aagtaaacat catgaagagc caggcacaac gtaaagcggc
    12601 tctcagccag ttcaatcccc aattaaacat gtatttcagc ggtggctggg caacggccac
    12661 acccaacttg ggatatgacg tatctttcaa tcccatcgta ggagtcaatc tgaatattcc
    12721 cattttccgc tggggagccc gtttcaagac gaaccggcag cagaaggcat atatcggaat
    12781 acaaaagctg caacagagtt atatgacgga caatatcaac gaagaactgt cggcagctct
    12841 cactaaactg acggaaacag aatctcaggt gaaaacagcg aaagaaaaca tgagtctggc
    12901 aaatgagaat ctggatctgg ccactttctc ctacaatgaa ggaaaagcga gcatggtaga
    12961 tgtactttcc gcccagttgt catggacgca agcacacacc aatctgatca atgcttatct
    13021 ggcagagaag atggctgtgg ctgaatacaa gaaggtgacc agcgaataga taaaaacaaa
    13081 attaggcacg gatgacacgg atttcacggt tttaagagtt gagtaactaa aaaccgtgtt
    13141 tatccgcgca atccgtgcct aatttttatt ggttgttctt tttattatgc aaggaaggag
    13201 atcagtacac ccgcagctac tgccgagccg attacccctg agatgttact tgccatacaa
    13261 tactgcaata catgattctt cggatcgtat ttcaacgcaa tctcattcgc cacacggctt
    13321 gccatcggaa cggcactcag tccggtagct ccgatcagcg gattaatctt cttcttggag
    13381 aatagattca ctaacttcac aaagaagata ccaccggtaa tagaaagagc aaatgcaagg
    13441 aaaccaccga tgacaatacc gattgtcgtc cagttcaaga aggcttcagc cgtcatggtt
    13501 gcacctaccg aaagtccgag gaagatggta gcggcattca tgatactgtt agaagcagca
    13561 tcgaacagac ggaaagtatt gcttccgatt tctttcacca gattaccgaa catcagcata
    13621 ccgatcaaag gtactgcact tgggacgaag agagctacaa ccgtagtcac tacaatcggg
    13681 aaaataatct tcagtacacg cagattctta atttccgtct tcgaaggata tttcttttct
    13741 tgttccttca tgttgatgct cagctctttc ttagtacaga acaacttcac taccagcgga
    13801 atgatcacag gcaccagtgc catataagaa taagcggcaa tagcgatcgg acccagcaaa
    13861 tgcggagcca gcttaatcgt tgtaaagatg gctgtcggtc cgtccgcacc accgataata
    13921 cccaatgaag cagcctcttg cggagtaaat cccatcagga tggctaccaa cagaacagta
    13981 aagataccca actgtgcggc agctccaaag atggaaagat gcagattacg caacatcggt
    14041 ccgaagtccg tcaacgcacc gacccccata aagatgatcg gaggcaggaa accggtcttg
    14101 atcagcatat aatagatgaa gttcataatt cccagttcat gcgcaatgtc atgcaaaggc
    14161 atttcccaga tattcttcat cacaccgttt atcatcacca taccattctc gtctgcctgt
    14221 atcactccca tatctcctcc ggggaagttg gcaagcaaca caccgaaagc aatcggaaca
    14281 agcagcagcg gttcgtactg tttcttgata cccagataaa gcaggacgaa cgcgatggca
    14341 tacattatca ggaactgcgg ttcggcaatg atattgctga acgcagtcat gtcatataag
    14401 ttctcaaata tctcgttcat tatcctatct tcattaatac atcatcttct gaaacagtgt
    14461 ctcccggatt ggcgcagata gcagttatcg taccgctaaa ttcggcacgg atagcgttgt
    14521 aagtcttcat tgcttccaca taacaaagca catcgccctc tttcaccgca tcaccaactt
    14581 tcaaggcaga ttcctgcgca ttcttcacca ggaagaattt accttccagc ggagaaagaa
    14641 catctttgcc ctctcctgcc ggagccgcag ctgcaggcgc agcaggcagt tcggcatctc
    14701 cgtatgctac cgtcacacga taagcctgtc cgtccacctg tacagtcagt gtctttggtt
    14761 ttgcatcttc ttccggcgat ttatctttct cggcacggcg ttttgccacg tctgccagga
    14821 agtcttcctt cgcttttcca ctcttgtaag cctcatactg
//
