LOCUS       c00014_gnlPro..        14976 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MHPCJGFC_14.
ACCESSION   c00014_gnlPro..
VERSION     c00014_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 17:30:50
            Original ID  :: gnl|Prokka|MHPCJGFC_14
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14976
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14976
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[119:4976]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      120..4976
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..14976
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14976
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             120..1352
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg14_1"
                     /sec_met_domain="HBT (E-value: 5.9e-16, bitscore: 53.0,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKLLVLDVDGTLLNDAKEISKRTLAALLKVQQMGVRIVLASGR
                     PTYGLMPLAKSLELGNYGGYILSYNGCQIINAQNGEILFERRINPEMLPYLEKKARKNN
                     FALFTYHDDTIITDTPENEHIQNEARLNNLKVIKEEEFSVAIDFAPCKCMLVSDDEEAL
                     VSLEGHWKRRLNGALDVFRSEPYFLEVVPCAIDKANTLGALLEELDVKREEVIAIGDGV
                     CDVTMIQLAGLGVAMGHSQDSVKVCADYVTASNEEDGVALAVEKAIIAEVRAAEIPLDQ
                     LNAQARHALMGNLGIQYTYADEDRVEATMPVDHRTRQPFGILHGGATLALGETVAGLGS
                     MILCQPDEIVVGMQVSGNHISSAHEGDTVRAVATIVHKGRSSHVWNVDVFTSTNKLVSS
                     IRVVNSVMKKR"
     CDS             1349..2461
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg14_2"
                     /sec_met_domain="Chorismate_bind (E-value: 8.7e-57,
                     bitscore: 186.9, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDEKSNLTTIDALIQRKQPFAVYRVPGEKYPRLLTEDVGAVRLI
                     FDLKELNGQRGFVIAPFRVDKSCPIVLIQSDRTGQPLPMEIVAEEEQGLQSYPEESFHT
                     LCTGKYATCFHTFIEALRDATFDKLVLSRSLTIGKNPEFSPSAVFRAACQRYIHSYIYL
                     CYTPQTGVWLGSTPEIILSGEKNEWNTVALAGTQPLQNGKLPQVWDDKNRQEQDYVASY
                     IRRQLLSLGIRSTESGPYPAYAGALSHLKTDFHFSLKDNKNLGDLLKVLHPTPAVCGLP
                     KEEAYRFILENEGYDRKYYSGFIGWLDPEGRTDLYVNLRCMHIEDEQLTLYAGGGLLAS
                     SELNDEWQETEKKLQTMRRILVSAPIMMNH"
     CDS             2481..4148
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg14_3"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.5e-07, bitscore:
                     23.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSDKKNILQLVALLEAHGITKVVLCPGSRNAPIVHTLSTHPGFT
                     CYAMTDERSAGYFAIGLALNGGHPAAVCCTSGTALLNLHPAVAEAYYQNIPLVVISADR
                     PAAWIGQMAGQTLPQPGVFQTLVKKSVNLPEIQTEEDEWYCNRLVNEALLETNHHGKGP
                     VHINIPISEPLFQFTVESLPEVRVITRYQGLNVYDRDYNDLIERLNRYQKRMIIVGQMN
                     LIYLFEKRHTKLLYKHFVWLTEHIGNQTVPGIPVKNFDAALYAMPEEKTGQMTPELLIT
                     YGGHVVSKRLKKYLRQHPPKEHWHVSADGEVVDLYGSLTTVIEMDPFEFLEKIAPLLDN
                     RVPEYPRVWENYCKTIPEPEFGYSEMSAIGALIKALPESCALHLANSSVIRYAQLYQVP
                     STIEVCCNRGTSGIEGSLSTAVGYAAGSDKLNFIAIGDLSFFYDMNALWNINVRPNLRI
                     LLLNNGGGEIFHTLPGLDMSGTSHKYITAVHKTSAKGWAEERGFLYQRVENEEQLAEAM
                     KTFTQPEAMEQPVLMEVFSNKNKDARILKDYYHQLKQK"
     CDS             4152..4976
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg14_4"
                     /sec_met_domain="ECH_1 (E-value: 5.7e-81, bitscore: 265.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTQREWTTIREYEDILFDYYNGIARITINRERYRNAFTPTTTAE
                     MSDALRICREEADIDVIVITGAGDKAFCSGGDQNVKGRGGYIGKDGVPRLSVLDVQKQI
                     RSIPKPVIAAVNGFAIGGGHVLHVVCDLSIASENAIFGQTGPRVGSFDAGFGASYLARV
                     VGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLEQLEDEYVQWAEEMMLLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATLLYYLTDEAQEGKNAFLEKRKPNFKKYPKFP"
     CDS             4980..6005
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg14_5"
                     /sec_met_domain="MR_MLE_C (E-value: 5e-28, bitscore: 92.5,
                     seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDCKIDIIPRVLHFKQPAGTSRGTYTTRKVWYLHFTAPEFPNWVG
                     IGECAPLPNLSCDDLPDYEEVLAKICRQVENQGGKLDMEALCKYPSILFGLETAIRHFF
                     EGSWALWDTPFSRGEAGIPINGLIWMGDFNRMLAQIEKKMEAGFRCIKLKIGAINFEEE
                     LALLQHIRSHYSFKEIELRVDANGAFSPTDAMEKLKRLSELDLHSIEQPIRAGQWEEMA
                     RLTSESPLPIALDEELIGYNTWEEKQRLLSAIRPQYIIIKPSLHGGLAGGEEWIAEAEK
                     LNIGWWITSALESNIGLNAIAQWCATFQNPLPQGLGTGLLFTDNVEMPLEIRKDCLWFC
                     K"
     CDS             6005..7108
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 52.9; E-value:
                     7.5e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg14_6"
                     /sec_met_domain="AMP-binding (E-value: 4e-16, bitscore:
                     52.9, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIFDRQKQRLLLEGKEYTPGDIHSLVAEGEGNHPSAIWDLYLFLN
                     EWFNDDPVITVHTSGSTGAPKELLVRKDQMIQSARLTCEFLDLKQGETALLCMNLRYIG
                     AMMVVVRSLIAGLNLIVRRASGHPLADVDTPLRFAAMVPLQVYNTFQIPEEKEKLKQTE
                     ILIIGGGAVDKALEEKIRNLSNAVYSTYGMTETLSHIALRRLNGAAASDRYYPFSSVEL
                     FLSSENTLMINAPLVCDDTLQTNDIARIYPDGSFTILGRKDNVINSGGIKVQAEEIERL
                     LQSSIPVPFVITSVPDRRLGQAVTLLIEGQMEISALGTKLESVLASYYRPKYIYTVNHI
                     PQTGNGKINRKECRVLAESLQLLGRQE"
     CDS             complement(7082..7651)
                     /locus_tag="ctg14_7"
                     /transl_table=11
                     /translation="MKISFSRQTKERAFKQLYEDYYAPFCLYAKRFVDDKEVREDIVSD
                     VFTSLWDKLDTDSFDLQSETALGYIKMCVKNSCLNFLKHQEYEWSYAENIQKKAPLYET
                     ETDSVYTLDELYRMLYETLNKLPENYRTVFMKSFFEGKTHAEIAEEMNLSVKSINRYKQ
                     KTMELLRNELKDYLPLFLLFLSPEQL"
     CDS             7864..8799
                     /locus_tag="ctg14_8"
                     /transl_table=11
                     /translation="LKENMENMNPESLLRKAQALGEDIKEMESIDVMGAYQQAQTQIKT
                     NRRRSMYNQLMRYAAFLTIPLLLSSLILGYLYWGATDTEEKYAEVMAATGSVIRYELPD
                     HSVVWLNSGSTLRYPTVFKKDNRNVELKGEAYFEVEADRKRPFYVNTPAGLSVYVYGTK
                     FNVNAYEDDNSIETVLEKGKVNVISPDGKTTVQLAPGERLLYNKVNQKLLKGKVDVYEK
                     VAWKDGKLIFRNAELGEIFKRLARHFNVDIQFNNISGKEYKYRATFRNETLPQILDYLA
                     KSAALKWRTEEAVQQADDTFTKKKIIVDLY"
     CDS             9049..12348
                     /locus_tag="ctg14_9"
                     /transl_table=11
                     /translation="MRISLALLFAVVLQLSAENGYAQRTHVAISMNNVSVEQVLNKIEE
                     ASDYVFLYNDKTIQKNRIVSVRNKSGKILDILDDIFKGTDITYTVVDKQIILSTNKMQL
                     VQQEGQIQIKGVVKDAGGDPLIGVNVKVKDSTVGTITDINGNFTLQTRKGDILEISYVG
                     YATKTVKVQNAQVLNIVLTEDTEVLNEVVVTALGIKKEAKSLSYNVQQVSNAEITRIAD
                     ANFVNNLNGKVAGVTINSSSAGVGGSSRVVMRGTKSLNGNNNALYVVDGIPMSDMSAAS
                     TQPTDSYEGAGQSGDPISGLNPEDIESISVLSGPSAAALYGSAAANGVVMITTKKGREG
                     RTSVSISNNTTFSAPLVLPEFQNTYGQTEVGSYYSWGSKLNTPSSYDPKDFFQTGVNVT
                     NAASLSTGTDKNQTYLSLGTTNAKGIIHNNDYERYNVTVRNVAKMLKDKLTLDLSFMLS
                     SVKEQNMTSQGLYYNPLVPLYLFPAGDDFSKVQAYQRYDSERNLLTQYWPYSTSLALQN
                     PYWITEHIKIPNHKNRYMATASAKYEFADWINVTARAKMDRNNERRERMYDAGTNTLFA
                     SKYGYYSKSNIENQQIYGELLLNINKYFVDNTLNVTANVGGNFENNDYQSDYFGGKLKS
                     VANLFTFGNVDTSEKNLANQYGYHLKKRAIFGSAQIGYKSMAYLDVTARNDWSSTFKGT
                     NTGSFFYPSIGLSGIITDIFRCSTDIMPYMKVRISYSEVGNSPDVFLAIPTYALVDGVP
                     VTQSRRPNPNLKPERTKSWEAGFNFVFFKNRLRLDGSIYQSRTYNQFFERTLSSTTGYK
                     SGVVNGGRVDNKGIELSLRFEDKWGNFGWSSYLTYSLNRNKVVELLRNYEDPYTHELTS
                     LDRIDMGGTSMYKMILTEGGSIGDIYVNTLRTDEHGAIYVHPSDQVVVTQPDEFVKAGN
                     SAPKYNLGWGNTFSYKGLSLGFLFTARVGGVVVSQTQATMDAYGSSKATAIARDNGGAI
                     VNGRPIGAEDYYTKIGGAGAQGGIGSMYTYSATNVRLAELSLGYDIPINKYVDWIKGLN
                     VSFIGKNLFFLYRKAPFDPELTASTGTYFQGIDMFMSPSLRNLGFSVKVNF"
     CDS             12373..13968
                     /locus_tag="ctg14_10"
                     /transl_table=11
                     /translation="MILNKILSWNKLSILGISLMLLNNISCIDYEDNVNPNEVTEEMME
                     VDNLKTGAFFSQMLRRVVIINDGDKLDSDYQIAQNLSHDLYSGYIAATLGSTNHNGQYN
                     FQEQWVNATFDYAYTGIMAPWQSIHKIATEQELPEVDALATIVKVEGMHRIADTFGPIP
                     YVNYGSSSLYDALDLVYNKFFEELDNAIEVLSNYVNGNVDAKLMSDYDCVYGGDVEKWV
                     KFANTLRLRLAICVSYANPTLAEAQAKKSMENMFGFIESKAERAELSHNSLEYHHPLHE
                     IAYNFNSGDCRPGATIVAYLNGLNDSRISSYFTAADDGEYHGVRIGITTSNMSNYQGNK
                     ISNLNINRASTPVVWMTAAESFFLRAEGALRGWDMGGTAKSFYEQGVRMSFEENNAAGV
                     DDYLADHTSTPGAFADNVGSDNYTFSSRVTPAWDDNAGFEAQLERIITQKWIANYPDGP
                     EGWSEYRRTGYPEVIPVVRNSSNGTIDTQLQVRRLPYTRDEKINNASGVASGISALGGK
                     DTGGAKLWWDKKSR"
     CDS             14011..14952
                     /locus_tag="ctg14_11"
                     /transl_table=11
                     /translation="MKTKITGLLTFLIGTFFFYSCDTDVEALEIQKLKTYDEQYFENLR
                     AFKKSDHEISYAYYEAWSPIEGVTGYKDPASWGERMVGLPDSIDIVNLWMGIPTAETHP
                     IAYADMQYCQRKLGTRFVMHADASHYRHQFTVDGVDYDLSQNKDDEAMAAYAKWIVNQV
                     LEPGLDGVDVDWEGWSGSDLVRLIKELGKYFGPEGEQPDKLLIVDYFSGTPPTDIIPYC
                     DYIVQQAYSDQVGFLTQPSNFPPEKMIYCESFGVFYADGGQLMNYARWEPSKGRKGGCG
                     VFYLGRNYYSSSGIPYNEFREAIQIMNPAVNE"
ORIGIN
        1 ttcgtgatta tttggaaatg catctgaaag agtgaaatta aagtaatttt tatctctttc
       61 cgctttcagt cgttcactca atttcctacc tttgtaatct aaatcaaaat cgtgtgtcca
      121 tgaagtataa attattagtt cttgatgtag acggaacgct tctcaatgat gcaaaagaaa
      181 ttagtaaacg tacattggct gctttgctga aagttcagca gatgggagta cgtatcgtgt
      241 tggcatccgg ccgaccgact tacggtctga tgcctttagc caaatcccta gaactcggaa
      301 attatggagg ttatatcctt tcttataatg gttgccagat aattaatgct caaaacggag
      361 aaatactgtt tgagcggagg attaatccgg aaatgttgcc ttatctggaa aagaaggcaa
      421 gaaaaaataa tttcgcactg ttcacttacc atgatgatac gatcattact gacactccgg
      481 agaatgaaca tatccagaat gaagctcgct tgaataattt gaaagtgatc aaggaagagg
      541 aattttctgt agcaattgac tttgctccgt gtaagtgtat gcttgtcagc gatgacgagg
      601 aagcgttggt tagtctggaa ggacactgga agagacggtt gaacggagct ttggatgttt
      661 tccgttccga accttatttt ctggaagtag tgccgtgtgc gattgataaa gccaacacat
      721 tgggagcttt attggaagaa ctggatgtga agcgtgaaga agtcatcgct ataggagacg
      781 gtgtgtgcga tgtaacgatg attcagctgg caggactggg agtggcgatg gggcattcgc
      841 aggattcggt aaaggtctgt gcggattatg tgacagcttc caatgaggaa gacggagtgg
      901 ctctggctgt cgaaaaggcg ataatagcgg aagttcgcgc tgcagagatt cctttggacc
      961 agttgaatgc acaggcgcgt cacgcattga tgggtaatct gggtatccaa tatacatatg
     1021 ccgacgaaga ccgtgtagag gcgacgatgc cggtagatca ccgtacccgt cagccgttcg
     1081 gtattttgca cggtggagct acgcttgcat tgggagaaac agttgccgga ctcggctcga
     1141 tgattctctg tcagccggat gaaattgtgg taggaatgca ggtcagcgga aatcatatat
     1201 cttctgcgca cgaaggtgat acagtacgtg cagtagcgac gattgtacac aaaggacgtt
     1261 cctcccatgt atggaatgtg gacgttttta cttcaaccaa taaactggtg tcctctatac
     1321 gggtggtcaa cagtgtgatg aaaaaaagat gattgacgaa aaaagtaact tgacaactat
     1381 tgatgcactt attcagcgga aacagccctt tgctgtttat cgtgttcccg gggagaagta
     1441 tcctcgtctg ttgacagaag atgtcggagc tgtccgcctg attttcgatt tgaaagaact
     1501 gaatggacaa agaggatttg tgattgctcc gttccgtgta gataagtcat gtccgattgt
     1561 gttgatacag tccgacagga ctggacaacc gttgcctatg gaaatcgtgg cagaggaaga
     1621 gcagggcttg caaagttatc cggaggaatc ttttcatacc ctttgtactg ggaagtatgc
     1681 gacctgtttt catacattta ttgaagcctt gcgtgatgct acctttgata aactggtgct
     1741 ttcccgtagt ctcactattg gaaagaatcc ggagttttcc ccttcagctg tttttcgtgc
     1801 agcttgtcaa cgttatattc attcctatat ctatctgtgt tatactcctc agacgggcgt
     1861 gtggctggga agtactcccg aaattatatt gtcgggcgaa aaaaatgaat ggaacacagt
     1921 tgccctggca ggaactcaac ctttgcagaa tggtaaactt ccgcaagtat gggatgacaa
     1981 aaaccgtcag gagcaggatt atgtggcgtc ctatatccgt cggcagcttc tttcgctggg
     2041 cattcgctcc acagagagcg gaccttatcc ggcttatgcc ggtgccttgt cacatctgaa
     2101 aactgatttc catttctctt tgaaagataa taaaaatctg ggagaccttc tgaaagtcct
     2161 gcatccgact cctgccgtgt gcggactgcc taaagaagaa gcctaccggt tcattttgga
     2221 aaatgaaggg tacgatcgta agtattattc cggttttatc ggttggctcg atccggaggg
     2281 acgcacagat ttgtatgtga atctgcgttg catgcacatt gaagacgagc aattgacact
     2341 gtatgccggt ggcggattgt tagcctcttc agagttgaat gatgaatggc aggaaacgga
     2401 aaagaaattg cagaccatga ggcgtattct tgtatctgct ccaataatga tgaatcacta
     2461 acaagctaat cactatcaat atgtattcgg acaagaaaaa tatactccag ttggtcgcgc
     2521 tgcttgaggc gcatggaatt acgaaagtag tgttatgtcc cggtagccgt aatgcaccta
     2581 ttgtgcatac gctgtctact catccgggtt ttacttgtta tgctatgacg gatgaacgga
     2641 gtgccggtta ttttgcgatt ggtcttgcgc tgaatggcgg gcatcctgct gccgtttgct
     2701 gtacttccgg tacagcgttg ctcaatcttc atcctgctgt ggcagaagcg tattatcaga
     2761 atataccttt agttgttatc tctgccgatc ggcctgctgc ctggattgga cagatggcgg
     2821 gacagacatt gccgcagccc ggtgtttttc agacattggt caagaagtcg gtaaaccttc
     2881 cggagattca gacagaagag gatgaatggt actgtaaccg cttggtgaat gaagccttgc
     2941 tggaaaccaa ccatcatgga aaaggtccgg tacatattaa tattcctata tccgaacctt
     3001 tgttccagtt tacggtggag tcgcttcccg aagtacgtgt catcacgcgc tatcaggggc
     3061 tgaatgtata cgaccgggat tacaatgacc tgatcgaacg cttgaacaga tatcagaagc
     3121 ggatgattat tgtcggacag atgaacttga tttacttgtt tgagaaacgg cataccaaat
     3181 tgttatataa acatttcgtg tggctgaccg agcatatcgg taatcagaca gtacccggta
     3241 ttccagtgaa gaattttgat gcggcgcttt atgcgatgcc cgaagagaaa accggccaga
     3301 tgactcccga gttattgatt acttatggcg gacatgtggt ttccaagcgg ttgaaaaaat
     3361 atcttcggca gcatccgcct aaagaacact ggcatgtgtc tgctgatgga gaagtggttg
     3421 acctttacgg ttctctgact accgtcatcg aaatggaccc gtttgagttt ctggagaaaa
     3481 tagctccatt gctggataac cgcgtgccgg agtatccccg tgtatgggag aattattgca
     3541 agaccattcc cgaaccggag ttcggatatt cggaaatgtc ggctatcggt gctttgataa
     3601 aagcattgcc ggaatcatgt gcattgcatc tggcaaatag ttctgttatc cgctatgctc
     3661 agttatacca ggttccttct acgattgagg tatgctgtaa tcggggtaca agcggcatcg
     3721 aaggctcgtt gtccacggca gtgggatatg ctgccggttc ggataaacta aattttatag
     3781 ctataggtga ccttagtttc ttttatgata tgaatgcttt gtggaatatc aatgtccgtc
     3841 ctaatctacg cattcttttg ctgaataacg gaggagggga gattttccat acattacccg
     3901 gactggatat gtcgggtaca tcgcacaagt atattacagc cgttcacaag acatctgcca
     3961 aaggatgggc ggaagaacgc ggattccttt atcaacgggt agagaatgaa gaacagcttg
     4021 ccgaagcgat gaaaaccttc acacaaccgg aagccatgga acaaccggtt ctgatggaag
     4081 tattcagcaa taaaaataaa gatgcacgta tactgaaaga ttattatcat caactaaaac
     4141 aaaaatagat tatgtcaaca caaagagaat ggacaaccat cagagaatac gaagatatcc
     4201 tctttgatta ctataatggg attgcccgca tcaccattaa ccgtgaacgc tatcgaaatg
     4261 catttactcc gactacaacg gctgaaatga gtgacgcatt gcgcatttgc cgggaagaag
     4321 cggatattga tgtgatcgtg attacgggag ctggtgacaa ggctttctgt tcgggcggtg
     4381 accagaatgt gaaagggcgt ggcggctata tcggcaagga cggtgttccc cgtctgagtg
     4441 ttctggatgt acagaaacaa atccgcagca ttccgaaacc ggtaattgct gccgtaaatg
     4501 gatttgccat tggtggcgga cacgtgcttc atgtagtttg cgatttatcg attgcttcgg
     4561 agaatgcgat cttcggacag accggtcctc gcgtaggtag ctttgatgca ggtttcggag
     4621 cctcttatct ggctcgtgtc gtcggtcaga agaaggcacg tgagatatgg ttcctttgcc
     4681 ggaaatacaa tgcgcaggaa gcgttggata tgggattggt gaataaagta gttccattgg
     4741 agcaactgga ggatgagtat gtgcaatggg cggaagaaat gatgctgctc agtccgttgg
     4801 ccttgcggat gattaaagcc ggattgaatg ccgaactgga cggccaggca ggtattcagg
     4861 agctggcagg ggatgcgacc ttgctttact atctgacgga tgaggctcag gaaggaaaga
     4921 atgcatttct ggagaaacgt aaacctaact ttaagaaata tccgaagttc ccttaaacaa
     4981 tggattgcaa aatagacatt attccgcggg tgcttcattt caagcagccg gccggaactt
     5041 cacgaggcac atacacaacg cgaaaagtct ggtatcttca ttttactgct cccgaatttc
     5101 ccaattgggt agggatcggg gagtgcgctc ctctgccaaa tcttagctgt gatgatcttc
     5161 ccgattacga ggaagtgctg gctaaaatct gccggcaggt agagaatcag ggaggtaagc
     5221 tggacatgga agctctatgc aagtaccctt ccatcctttt tggcttggag acagccattc
     5281 gtcacttttt tgaaggaagc tgggctttgt gggatacacc cttctcacgt ggggaagcag
     5341 gtattccgat aaacgggctt atctggatgg gtgacttcaa tagaatgctt gctcagatag
     5401 agaagaagat ggaggcggga ttccgctgta taaagttgaa gatcggtgcc atcaactttg
     5461 aagaagaact ggctttactc caacatatcc gctctcacta ttcttttaaa gaaatagaat
     5521 tgcgtgtaga tgccaacgga gcattctcgc caacagatgc gatggagaaa ttgaaacgct
     5581 tgtccgaact ggacttacat tcgatagaac agcccattcg tgccggacaa tgggaagaaa
     5641 tggcacgtct tacttccgaa tctcctttgc cgatagcttt ggatgaggaa ctgataggct
     5701 ataatacctg ggaagaaaag caaagattac tttcggctat ccgtccgcaa tatattatta
     5761 tcaaaccttc tcttcatggc ggattagccg gtggcgagga gtggattgca gaagcggaga
     5821 aactgaatat cggttggtgg ataacttctg ctctggagtc taatatcggt ctgaatgcta
     5881 tcgctcaatg gtgtgctact tttcagaatc cattgccgca agggttaggc accgggttac
     5941 tctttacaga taatgtagag atgcctcttg aaatcagaaa agattgtttg tggttttgta
     6001 aatgatgata ttcgaccgac aaaaacagcg tttgttgctg gagggaaagg aatatactcc
     6061 gggcgatata catagccttg tagcagaagg tgagggaaac cacccttctg ctatatggga
     6121 cttgtatctt tttctaaacg aatggtttaa tgatgatcct gtgatcactg tacatacttc
     6181 cggttctacg ggggcaccta aagaattgct tgttcgcaaa gatcagatga tacagagtgc
     6241 acgcctgact tgtgagtttc tggatttaaa gcagggtgaa acggcattat tgtgtatgaa
     6301 ccttcgctat atcggggcga tgatggtagt cgtccgttct ttgattgccg ggttgaatct
     6361 tatagtacgt cgggcttccg gtcatccatt ggcagatgtg gacactcctt taaggtttgc
     6421 ggctatggtg cctttgcagg tgtataatac atttcagata cccgaagaga aagagaaatt
     6481 aaagcaaacg gagattttaa ttataggagg cggagcagtt gacaaggctt tagaggaaaa
     6541 aatcagaaat ctgtccaatg ctgtttattc aacttacggg atgacggaaa ccctttctca
     6601 catcgctctt cgccgtctga atggcgcagc agcatccgat cgttattatc ctttttcatc
     6661 cgtagagttg tttttgtctt cagaaaatac tttgatgatt aatgctccgc ttgtttgcga
     6721 tgatactctg cagacaaatg atattgcccg catttatccg gacggtagtt ttacgattct
     6781 gggaagaaag gataatgtaa tcaatagcgg aggaattaaa gtgcaggcag aagagatcga
     6841 aaggttactt cagtcgtcta tccctgtacc gtttgtgatc acttccgttc cggatcggcg
     6901 tttggggcag gctgttactt tattgataga agggcagatg gagataagtg cgctagggac
     6961 taaattggaa tcagtcttag catcttatta tcgtcctaaa tatatttata cggtaaatca
     7021 tattcctcaa acgggaaatg ggaagattaa tcgtaaagag tgccgtgttt tagcagagag
     7081 cttacagttg ctcgggagac aggaataata aaaacagcgg gaggtaatct ttcaactcgt
     7141 tccgcaggag ttccattgtt ttttgtttat accgattaat ggattttacg ctgagattca
     7201 tttcttcggc aatttccgca tgtgttttgc cttcaaagaa acttttcata aatacggtgc
     7261 gatagttttc cggaagctta tttaatgttt cgtatagcat tcggtataac tcatcaagtg
     7321 tatatacact atctgtttct gtttcatata gaggagcttt cttttggata ttttcggcat
     7381 aactccattc atactcctga tgtttcagaa agttcaaaca gctgtttttt acacacattt
     7441 ttatatatcc caatgctgtc tctgattgca aatcgaaaga gtcggtatcc aacttgtccc
     7501 atagggaggt gaatacatcc gaaacaatgt cctcgcggac ttctttatca tctacaaatc
     7561 tttttgcata caggcagaaa ggggcataat aatcctcgta aagttgtttg aaagctcttt
     7621 ctttagtctg tctggaaaaa gatattttca ttattttgag attctgtagt ttttcatttt
     7681 actgcaaata tataataaga aaatcagcat ttcctaaaat tttctttctt tttttgtttt
     7741 tggtatgaag ctgtggaaaa taagatagct taaaaaataa aataaaaaaa agtatgttat
     7801 acctgtccct tttcgattac ctcagttgta ctattagtgt aattgcaatt aaaagataag
     7861 attttgaaag agaatatgga aaatatgaat ccggaatcat tgctccgaaa agcgcaggca
     7921 ttaggagagg atattaagga aatggagtct attgatgtaa tgggtgccta tcaacaagca
     7981 cagacccaaa taaagacaaa cagaagaagg agtatgtata atcagttgat gcgttatgct
     8041 gcattcttga ctataccttt attactttct tctttgattt tgggatattt atattgggga
     8101 gcaacggata ctgaagagaa gtatgcagaa gtcatggcgg ctacaggttc agtcattcgt
     8161 tacgaacttc ctgaccattc ggttgtctgg ttaaactccg gtagtacttt acgttatcct
     8221 accgttttta agaaagataa tcgtaatgtt gaattaaaag gtgaagccta ttttgaagta
     8281 gaagcggaca ggaaacggcc tttttacgtc aatactcctg ccgggttaag tgtctatgtg
     8341 tacggaacca aatttaatgt gaatgcttac gaagatgata atagtataga aacggtatta
     8401 gaaaagggta aagtaaacgt tatttcaccg gacggaaaaa caacagttca gttagctcca
     8461 ggagaacgat tgctttataa taaggtaaat cagaaattgt tgaagggaaa agtggatgtt
     8521 tatgaaaagg tggcatggaa agacggtaag ttgatattcc gcaatgccga gttgggtgaa
     8581 atattcaaac ggctggcacg gcattttaat gtagatattc agtttaataa tatatcggga
     8641 aaagaatata aatatcgtgc gaccttccgt aatgaaacac tgccacagat attggattat
     8701 ctggctaagt ctgctgcctt gaagtggaga actgaggagg cggtacaaca ggcagatgat
     8761 acattcacaa agaaaaagat aatagtagat ttatattagt aaccataaaa atgagaatag
     8821 cctatgagat aacacaaaga tcgtaaaaaa aggaagaaag ctgctaccaa cagctgtctt
     8881 cccccaattt ttcagattcg cggtaaggag tcttgcaaac gctaaccgga atcaaaccac
     8941 agttcattat agtaataaac tttagttaac cgcaaatgta tgaaaaaaaa tcattcattt
     9001 attgcattat atcctaaata tgctttaaat ctaaaactac ctttagttat gaggattagt
     9061 ctggcactac tttttgcagt cgttttacaa ctatctgcag agaatggcta tgctcaacgg
     9121 acgcatgttg ccatttctat gaacaatgta tctgtagaac aggtactgaa taaaatagaa
     9181 gaagcttccg attatgtttt cctttacaat gacaaaacga ttcagaagaa tcgtattgtt
     9241 tctgtgagaa ataaatcagg taagattctg gatattctag atgatatttt taaggggacc
     9301 gatattacgt ataccgtagt tgacaagcag attattttat cgactaataa aatgcaactt
     9361 gttcagcagg aaggacaaat ccaaataaaa ggagttgtga aagatgctgg cggagatccc
     9421 ttgatcggtg tgaatgtgaa agtgaaagat tctacggtcg gtactatcac cgatataaac
     9481 ggaaacttta cgctacagac caggaaagga gatattctgg aaatttctta tgtgggatat
     9541 gccacgaaaa cagtaaaggt acagaatgcc caagttctga atattgtgct gacagaagat
     9601 acagaagtac tgaatgaagt cgttgttact gcattgggta tcaagaagga agctaaatct
     9661 ttgtcataca atgtacagca agtaagcaat gccgagatta cacgcattgc agatgccaac
     9721 ttcgtcaata atctgaacgg taaagttgcg ggtgttacaa ttaactcatc ttcagctggt
     9781 gtcggtggct cttcacgtgt agtgatgcgt ggaaccaaat cattgaatgg taataacaat
     9841 gctctttatg tggttgatgg tatcccgatg agtgatatga gtgccgcttc tacacagcct
     9901 acggactcat acgaaggtgc cggtcagtcc ggtgatccta tttccggtct gaatcccgag
     9961 gatatagaga gtatctctgt tttgagtgga ccgtcagctg cagctcttta cggtagtgcc
    10021 gctgccaatg gtgttgtgat gattactact aaaaaaggta gggaaggacg tacttcagtc
    10081 agcatatcca ataatacgac tttctccgct cctcttgtct tgcccgaatt tcaaaatact
    10141 tatgggcaga cagaagtggg tagttactac agctggggca gtaaattgaa tacgccgagc
    10201 agctatgatc ctaaagactt ctttcagaca ggtgtgaatg taacaaatgc tgccagtctt
    10261 tctacaggta ctgacaagaa tcagacttac ttatctttag gtactaccaa tgccaaaggt
    10321 attatccata ataatgacta cgaacgttac aatgtcactg tccgtaatgt tgccaagatg
    10381 ctgaaagata agctgactct tgacctgagt tttatgctta gctctgtaaa agaacaaaat
    10441 atgacctctc agggacttta ttataacccg ttagtacctc tttatctatt tcctgcggga
    10501 gatgatttct ccaaagtaca ggcatatcag cggtatgatt cggaacgaaa tttactgact
    10561 cagtactggc cttacagcac aagtctggct ttacagaatc catactggat taccgagcat
    10621 attaaaatac ctaatcataa gaaccgttat atggcaactg catcggcaaa atatgaattt
    10681 gctgactgga ttaatgtaac agcccgtgcc aaaatggacc gcaacaacga acgccgtgag
    10741 cgcatgtatg atgccggaac aaatactttg tttgcttcta aatacggtta ttactccaag
    10801 agtaatatcg agaatcaaca gatatacggt gaattattgc tgaatattaa taagtacttt
    10861 gtcgataata ccctaaatgt aacagctaat gtgggtggga actttgaaaa caatgattat
    10921 cagtctgatt atttcggagg caaactgaag tcggtagcca acctctttac ttttggcaac
    10981 gtggatactt cagagaagaa tctggccaac caatatggct atcatttgaa aaaacgcgcc
    11041 atattcggta gtgctcagat cggttacaag tctatggctt atctggatgt gacggctcgt
    11101 aacgactggt catctacctt caaagggacg aataccggtt ctttcttcta tccgtctatc
    11161 ggtctttcgg ggattatcac agatatattc cgttgcagta cggatattat gccatacatg
    11221 aaagtacgta tttcttattc ggaagtaggt aattcaccgg atgtatttct ggctattccg
    11281 acttatgcgt tggttgatgg cgttcctgtt actcagtccc gacgtcctaa ccccaatctg
    11341 aagccggaac gtaccaaatc atgggaagcc ggatttaact ttgtcttctt caagaaccgt
    11401 ttgagattgg atggatctat ctatcagtca cgtacctaca atcagttctt tgaacgtacc
    11461 ctttcttcta ctaccggcta taaatcggga gtagtcaatg gcggtcgtgt agataataaa
    11521 ggtatcgaat tgtctttgcg ttttgaggac aaatggggaa attttggctg gagttcgtat
    11581 ctgacctatt cattgaaccg aaataaagtg gtggaattgc tgcgcaacta tgaagatcct
    11641 tatacgcacg aacttacttc tttggataga attgatatgg gcgggacaag tatgtataaa
    11701 atgatactga cagaaggcgg atctatcggc gatatttatg tgaatacgct tcgcacggac
    11761 gaacatggag ctatctatgt ccatccttcg gaccaggttg tagttactca gcctgatgaa
    11821 tttgtaaagg ctggtaatag tgctcctaag tataacctcg gttggggaaa cacattcagt
    11881 tacaaagggc tttcattggg attcctgttc acggcacgtg tcggtggtgt agttgtatca
    11941 cagacacagg cgacgatgga cgcatacggc tcttcaaagg ctacagctat tgcccgtgat
    12001 aatggcggag ccattgttaa cggtcgtcca atcggtgcgg aagattacta tacgaaaatt
    12061 ggaggtgcag gtgctcaggg tggtattggt tctatgtaca cctacagtgc gactaatgtc
    12121 cgtttggctg agttatcgtt aggctatgat attcctatca acaagtatgt ggactggatt
    12181 aaggggttga acgtatcttt catcggtaag aatctctttt tcctttatag aaaagctccg
    12241 ttcgatccgg aactgacagc aagtacaggc acttactttc aaggtatcga catgtttatg
    12301 tcgccaagtc tgcgtaattt gggattctct gtgaaagtta atttctaatc aaacttataa
    12361 attgtagaag atatgatatt aaataaaata ctatcatgga acaaactttc cattctcggg
    12421 atatctttga tgctattaaa taacatttcg tgtatcgact atgaggataa cgtaaatccg
    12481 aatgaagtca ccgaggaaat gatggaagta gacaacttga agacgggtgc tttcttttcg
    12541 caaatgctgc gtcgggttgt aatcataaat gatggcgaca agctcgactc tgactatcag
    12601 attgctcaga acttatcgca tgacctttat tcgggctata ttgccgctac cttaggatct
    12661 actaatcata acgggcagta taactttcag gaacaatggg tgaatgccac ttttgattat
    12721 gcctataccg gaattatggc accatggcaa agtattcaca aaatagccac tgaacaggaa
    12781 ctgccggaag ttgacgcatt ggctaccatc gtaaaggtag aaggcatgca ccgtattgct
    12841 gatacatttg gtcctattcc atatgtaaac tatggctctt ccagcttata tgacgcattg
    12901 gatttggttt ataataagtt ttttgaagaa ctggataatg ctatcgaagt attgagcaat
    12961 tatgtgaacg gaaatgtgga tgctaagctg atgagtgact atgactgtgt atatgggggg
    13021 gacgtagaga agtgggtgaa gttcgccaac acactgcgtt tgcgtcttgc tatatgtgtt
    13081 tcatatgcga atcccacact ggcagaagca caggcaaaga agtcgatgga aaacatgttc
    13141 ggctttatcg aaagtaaagc ggaacgtgcc gaactttcgc ataattcatt ggaatatcat
    13201 catccgttgc acgagattgc ctataacttc aattcgggtg actgtcgtcc gggtgctacc
    13261 atcgtagcct atttgaacgg actgaatgat tcgcgaatca gctcttattt tacagcagcc
    13321 gatgacggtg aatatcatgg cgtacgtatt ggtatcacaa caagcaatat gagcaattat
    13381 caaggcaata aaatctctaa tctgaatatt aaccgtgctt ctactccggt agtatggatg
    13441 acggctgccg aatcgttctt cctgcgtgcc gaaggtgcat tacgtggctg ggatatgggt
    13501 ggaacggcca aatcattcta tgagcaaggt gtacgcatgt cgtttgagga gaataatgcc
    13561 gccggtgtag acgattattt ggctgatcat acttcgactc cgggtgcttt tgcagacaat
    13621 gtgggtagtg ataattatac tttcagcagc agggttactc ctgcatggga tgataatgcc
    13681 ggatttgaag ctcagttgga acgcatcatt acacagaagt ggattgccaa ttatcccgac
    13741 ggtcccgaag gctggagtga atatcgtcgt acaggctatc cggaagttat tcctgtagta
    13801 agaaacagta gtaatggtac gattgatacc cagttacaag tccgccgtct gccttataca
    13861 cgcgacgaga agatcaacaa tgctagcggc gttgccagtg gtatatcggc tttgggtggt
    13921 aaggatacgg gtggagctaa actctggtgg gacaaaaaat cccgataaca ggagaatgga
    13981 cattgtttaa ttctaaaaac actaattacg atgaaaacaa aaataacagg tttactgact
    14041 ttccttatcg gaacattctt tttctatagt tgtgataccg atgtggaagc gttagaaatt
    14101 cagaagctga aaacatatga cgagcagtat tttgagaatc tgcgtgcttt caagaaaagc
    14161 gatcatgaga taagttatgc ttattacgaa gcgtggtcac cgattgaagg tgtgacaggc
    14221 tataaagatc ccgcgtcgtg gggtgaacgt atggtaggac tacctgacag tatagatatt
    14281 gtaaatcttt ggatgggaat accgacagca gagacacatc cgatagcata tgcggatatg
    14341 caatactgcc agcggaaatt gggtacacgt tttgtcatgc atgccgatgc ttctcattac
    14401 agacaccagt ttaccgttga tggggttgat tatgatctta gccagaataa ggacgatgaa
    14461 gcgatggctg catatgcaaa atggattgtg aatcaagtgt tggaaccggg acttgatgga
    14521 gtagacgttg actgggaagg ttggagtggt tccgatttgg tcagattgat aaaggaactt
    14581 ggcaagtatt ttggtcctga aggcgaacag ccggataagt tgcttatcgt tgactacttt
    14641 agtggaacac caccaacaga catcatacct tattgtgatt atatcgttca acaggcttat
    14701 agtgatcaag tggggttctt gactcaaccc agtaactttc cacccgagaa gatgatttac
    14761 tgcgaatcgt tcggagtatt ctatgccgat gggggacaac ttatgaacta tgcacgttgg
    14821 gaaccgtcga aaggccgtaa aggcggttgt ggagtattct acttaggaag aaattattat
    14881 tcttcatcgg gtatacctta taatgaattc cgggaggcta ttcagataat gaatcctgct
    14941 gtaaatgagt aaacaatgaa taaataagaa tcatga
//
