LOCUS       c00054_gnlPro..        15599 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DKJOAIGO_54.
ACCESSION   c00054_gnlPro..
VERSION     c00054_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 23:14:55
            Original ID  :: gnl|Prokka|DKJOAIGO_54
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15599
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..759)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg54_1"
                     /sec_met_domain="IlvN (E-value: 2.9e-47, bitscore: 150.8,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 3.4e-17, bitscore: 53.6,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGTVENVVIRDEFPLEKAREVLKNETIAVIGYGVQGPGQ
                     ALNLRDNGFNVIVGQRQGKTYDKAVADGWVPGETLFGIEEACEKGTIIMCLLSDAAVMS
                     VWPTIKPYLTAGKALYFSHGFAITWSDRTGVVPPADIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAIYQDATGNAMDRTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLM"
     protocluster    1..15599
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[0:5599]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1..5599
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..15599
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15599
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(823..1566)
                     /locus_tag="ctg54_2"
                     /transl_table=11
                     /translation="MSEENKIGTYQFVAEPFHVDFNGRLTMGVLGNHLLNCAGFHASDR
                     GFGIATLNEDNYTWVLSRLAIELDEMPYQYEKFSVQTWVENVYRLFTDRNFAVIDKDGK
                     KIGYARSVWAMINLNTRKPADLLALHGGSIVDYICDEPCPIEKPSRIKVTSNQPVATLT
                     AKYSDIDINGHVNSIRYIEHILDLFPIELYQTKRIRRFEMAYVAESYFGNELSFFCDEV
                     SENEFHVEVKKNGSEVVCRSKVIFE"
     CDS             complement(1566..2129)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg54_3"
                     /sec_met_domain="ALS_ss_C (E-value: 1.2e-19, bitscore:
                     60.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDKTLYTIIVHSENIAGLLNQVTAVFTRRQINIESLNVSASSIK
                     GVHKYTITAWTDKDTIEKVVKQIEKKIDVIQAHYFTEDEIYFHEIALYKVSTPAFQETP
                     EASKVIRRYNARIVEVNPVFSIVEKNGMSEEITSLYEELRALKCVLQFVRSGRVAITTS
                     CFERVNEFLDGQEAKYKQSKKEQE"
     CDS             complement(2148..3623)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg54_4"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.2e-47, bitscore:
                     149.9, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LVTSGPGATNTITGIADAMIDSTPIVVIAGQVGTGFLGTDAFQEV
                     DLVGITQPIAKWSYQIRRAEDVAWAIARAFYIASSGRPGPVVLDFAKNAQVEKTKYEPT
                     QQEFIRSYVPVPDTDEESVKAAAKLINNAERPLVLVGQGVELGSAQEELRIFIEKADMP
                     AGCTLLGLSALPTDHPLNKGMLGMHGNLGPNINTNKCDVLIAVGMRFDDRVTGNLATYA
                     KQAKVIHFDIDPAEVNKNVKVDIAVLGDCKKTLAAVTGLLKKNRHTEWVDSFKEYEAVE
                     EEKVIRPELHPATDSLSMGEVVRAVSEATRHEAILVTDVGQNQMISARYFKYTRERSIV
                     TSGGLGTMGFGLPAAIGATFGRPDRTVCVFMGDGGLQMNIQELGTIMEQKAPVKIICLN
                     NNYLGNVRQWQAMFFNRRYSFTPMLNPDYMKIASAYDIPSKRVFSREELKAAIDEMLST
                     DGAFLLEACVVEEGNVLPMTPPGGSVNQMLLEC"
     CDS             complement(3893..5599)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg54_5"
                     /sec_met_domain="ILVD_EDD (E-value: 9e-218, bitscore:
                     714.4, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGKPIIAIVNSFTQFVPGHVHLHEIGQLVKAEIEKLGCFAAEFNT
                     IAIDDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHKADAVVCISNCDKITPGMLMAAMR
                     LNIPTVFVSGGPMEAGEWNGQHLDLIDAMIKSADDSVSDQEVANIEQNACPTCGCCSGM
                     FTANSMNCLNEAIGLALPGNGTIVATHENRTKLFEDAAKLIVENAMKYYEEGDESVLPR
                     SIATRQAFLNAMTLDIAMGGSTNTVLHLLAVAHEAGVDFKMDDIDMLSRKTPCLCKVAP
                     NTQKYHIQDVNRAGGIIAILAELAKGGLIDTSVLRVDGMSLAEAIDQYSITSPNVTEKA
                     MSKYSSAAGNRFNLVLGSQGAYYQELDKDRANGCIRDLEHAYSKDGGLAVLKGNIAQDG
                     CVVKTAGVDESIWKFTGPAKVFDSQEAACEGILGGRVVSGDVVVITHEGPKGGPGMQEM
                     LYPTSYIKSRHLGKECALITDGRFSGGTSGLSIGHVSPEAAAGGNIGKIVDGDIIEIDI
                     PARTINVRLTDEELAARPMTPVTRDRYVPKSLKAYASMVSSADKGAVRLID"
     CDS             6170..6754
                     /locus_tag="ctg54_6"
                     /transl_table=11
                     /translation="METVENKYITVAYKLYTVEDGEKELFEETNAEHPFQFISGLGTTL
                     ESFENQITALSKGDKFDFTIPADEAYGAYDEQHVFDLPKNIFEIDGKFDSERVTEGSIV
                     PLMTGDGQRVNASVVEIKPDVVVVDLNHPLAGADLIFEGEVIESRPATNEEIQELVKMM
                     SGEGCGCGCDSCGSDCGDCGDDCGCEGGHCH"
     CDS             complement(6893..8182)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SDH_alpha"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg54_7"
                     /sec_met_domain="SDH_alpha (E-value: 1.7e-62, bitscore:
                     201.8, seeds: 645, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIESERKQIIDLIKKEVIPAIGCTEPIAVALCVAKAAETLGMKPE
                     KIEVLLSANILKNAMGVGIPGTDMVGLPIAVALGALIGRSEYQLEVLRDCTPEAVEQGK
                     LFIAEKRICISLKEDITEKLYIEVICTAGSQKATAVIAGGHTTFVYIATDEKVLLDKQQ
                     TANEEEEDASLELNLRKVYDFALTSPLDEIRFILDTARLNKAAAEQAFKGNYGHSLGKM
                     LRGTYEHKVMGDSVFSHILSYTSAACDARMAGAMIPVMSNSGSGNQGISATLPVVVFAE
                     ENGKTEEELIRALMLSHLTVIYIKQSLGRLSALCGCVVAATGSSCGITWLMGGNYNQVA
                     FAVQNMIANLTGMICDGAKPSCALKVTTGVSTAVLSAMMAMEDRCVTSVEGIIDEDVDQ
                     SIRNLTRIGSQAMNETDKMVLDIMTHKGGC"
     CDS             8742..9401
                     /locus_tag="ctg54_8"
                     /transl_table=11
                     /translation="MEWASGNAGYAMTGVPKTADDYPTFQFANGKTGKCLSLVTRSTGF
                     FGSIMGMPIAAGNLFIGSFDVGNAMSNPLKATKFGLPFRHIPTYLAGYYKYKAGDQFTE
                     GGKPVSGKRDICDIYAIMYETSESVPTLDGTNAFTSPNLVSIARIDDAKETDEWTYFKL
                     PFHMLSGKYIDKEKLTAGKYNVAIVFTSSLEGDHFNGAIGSTLLIDEVELIYRSED"
     CDS             9492..10277
                     /locus_tag="ctg54_9"
                     /transl_table=11
                     /translation="MKIHSYIFSLLACLVIALPGYSQVDRNETLIRSALHGLEYEIKAG
                     FSIGGTAPLPLPVEIRSIDGYNPTLAISIGGEVTKWFAVQNKLGVIVGLRLENKAMTTE
                     ATVKNYNMEILGQGGERISGVWTGGVKTKVHTSGLTIPLMATYKLSNRWNIKAGPYFSY
                     LLSREFSGHVYEGYLREGDPVGPKVEFTDGKIATYDFSDDLRHFQWGLQIGAGWRAFKH
                     LNIYADLTWGLNDIFRNDFQTITFAMYPIYLNIGFGYAF"
     CDS             complement(10293..10856)
                     /locus_tag="ctg54_10"
                     /transl_table=11
                     /translation="MKKNLLYLWALICSVSLLTACSSDDDNTVNDETTPPEEEAVVTAP
                     DVVGTYWGNLDISMLPDGSDQEVVIADGLPKFITFSQVSDTEVKMELKEFELFINGNIL
                     KFGDIVIDKCAVKKETDASTFTGQQDLTFQGDAAALGTCATSIEGTVQSGNATMNIQVK
                     VPALKQTVKVAFSGVKQVEESGKD"
     CDS             11015..12091
                     /locus_tag="ctg54_11"
                     /transl_table=11
                     /translation="MFNSFGNIFRLTSFGESHGKGVGGVIDGFPSGITIDEEFVQQELN
                     RRRPGQSILTTPRKEADKVEFLSGIFEGKSTGCPIGFIVWNENQHSNDYNNLKEVYRPS
                     HADYTYKVKYGIRDHRGGGRSSARETISRVVAGALAKLALRQLGISITAYTSQVGAIKL
                     EGTYSDYDLDLIETNDVRCPDPEKAKEMADLIYKVKGEGDTIGGTLTCVIKGCPIGLGQ
                     PVFGKLHAALGNAMLSINAAKAFEYGEGFKGLKMKGSEQNDVFFNNNGRIETHTNHSGG
                     IQGGISNGQDIYFRVVFKPIATLLMEQETVNIDGVDTTLKARGRHDACVLPRAVPIVEA
                     MAAMTILDYYLLDKTTQL"
     CDS             12436..13557
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M20"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg54_12"
                     /sec_met_domain="Peptidase_M20 (E-value: 7.9e-39, bitscore:
                     123.9, seeds: 360, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LVYAHYDVMPAEPLELWKSQPFEPEVRDGYIWARGADDDKGQSFI
                     QVKAFEYLVKNELLKNNVKFIFEGEEEIGSPSLEAFCEEHKELLKADVILVSDTSMLGA
                     ELPSLTTGLRGLAYWEIEVTGPNRDLHSGHFGGAVANPINVLCEIISKVTDKDGRITVP
                     GFYDDVEEVPQAEREMIAHIPFDEKKYKEAIGVKELFGEKGYSTLERNSCRPSFDVCGI
                     WGGYTGEGSKTVLPSKAYAKVSCRLVAHQDHHKISQMFADYILQMAPDTVQVKVTPMHG
                     GQGYVCPISLPAYQAAEKGFEIAFGKKPLAVRRGGSIPIISTFEQVLGTKTVLMGFGLE
                     SDAIHSPNENFSLDIFRKGIEAVIEFHQEYAKR"
     CDS             complement(13683..14741)
                     /locus_tag="ctg54_13"
                     /transl_table=11
                     /translation="MKKKLTGVALVLAAVSLMGIQPAGACTRAVYLGPDRMVVTGRTMD
                     WKEDIMSNIYVFPRGMQRAGHNKEKTVNWTSKYGSVIATGYDIGTCDGMNEKGLVASLL
                     FLPESVYSLPGDTRPAMGISIWTQYVLDNFATVREAVDEMKKETFRIDAPRMPNGGPES
                     TLHMAITDETGNTAVIEYLDGKLSIHEGKEYQVMTNSPRYELQLAVNDYWKEVGGLQML
                     PGTNRSSDRFVRASFYIHAIPQTADAKIAVPSVLSVMRNVSVPFGINTPEKPHISSTRW
                     RSVSDQKNKVYYFESTLTPNLFWLDLKKIDFSPKAGVKKLSLTKGEIYAGDAVKDLKDS
                     QSFTFLFETPVM"
ORIGIN
        1 catcaatgac tgagtcagct cttctacagt ttcgttgaat gcttcggaag gagtgtgacc
       61 gttttcacgc aacacttcgt attgtgccag caacagaccc tggatagctc ccatcaatga
      121 accacgttcg cctgtcaggt cggaagtagc ttcgcggatg aaagttgttt cgaacaaata
      181 acctgaaccg ataccgatac ccaatgcgat tgttctgtcc atagcgttgc ctgttgcatc
      241 ctgatagata gcgtaagaag agttcaagcc gcgaccttca aggaacatag tacgcaagga
      301 tgtacccgaa cctttaggag caaccatgat tacgtcgata tctgcaggag gaactacacc
      361 tgtgcggtca ctccatgtaa tagcaaaacc atgagagaaa taaagagctt ttcctgcagt
      421 caggtaaggc ttgatagtag gccatacaga cattactgct gcatcagaca acaggcacat
      481 aatgatcgta cctttttcgc aagcttcttc aataccgaac aaagtttcac ccggaaccca
      541 tccgtcagca accgctttgt catatgtctt tccctggcgt tgaccaacga ttacattgaa
      601 accgttatca cgaaggttca gagcctgtcc gggaccttgt acgccataac cgattacagc
      661 gattgtttca tttttcaata cttcacgagc tttttccaat ggaaattcat cacggataac
      721 tacattttct acagttccgc caaaattcaa ctgtgccatt ttttttgttt ttttgttttg
      781 atgacttgcg ccatctgtta ttaattgatt ttatactcta tattattcaa atatcacttt
      841 ggaacggcat actacctcgc tgccgttttt cttcacctct acatgaaact cgttttcact
      901 cacctcatca cagaagaaag agagttcatt tccgaaataa ctttcagcca catacgccat
      961 ttcaaaccgg cggatacgtt tcgtctgata cagttctatc ggaaacaagt caagtatgtg
     1021 ctcgatataa cgaatactgt ttacgtgtcc gttaatatcg atatcactgt attttgccgt
     1081 cagcgtcgca acaggctgat tgcttgtcac cttgatacgc gaaggctttt ctatcgggca
     1141 gggttcatcg catatataat cgacgatgct tcctccatgc aatgccaaca gatcggcagg
     1201 cttacgagta ttcagattga tcatcgccca tacggaacgg gcatagccga tcttctttcc
     1261 atccttgtca atgacggcaa agttacggtc ggtaaagaga cgatagacat tctccaccca
     1321 tgtctgaacc gagaacttct cgtattggta aggcatctcg tccagctcga tcgccagacg
     1381 ggaaagcacc catgtgtaat tgtcctcgtt cagcgtagca ataccaaatc cacggtcgct
     1441 ggcatgaaaa cctgcgcaat tcagcagatg attccccagc acgcccatgg tcaggcggcc
     1501 gttaaaatct acgtgaaacg gctctgccac aaactgataa gtccctattt tattttcttc
     1561 actcattact cctgttcctt tttactttgc ttatacttcg cttcctgtcc gtccaggaac
     1621 tcattcacac gttcgaaaca gctggtagta atagccacac ggcccgaacg gacaaattgc
     1681 agcacacatt tcaaagcccg aagttcttcg taaagggaag taatctcttc actcatgccg
     1741 ttcttctcga cgatagagaa taccggattc acctctacaa tgcgggcatt atatctgcgg
     1801 atcactttag atgcttccgg agtctcctga aaagcaggag tagatacctt atataaggct
     1861 atctcatgga aataaatctc gtcttccgta aaatagtgcg cctgaatcac atcaatcttc
     1921 ttttcgatct gcttcaccac cttttcgata gtgtccttat cagtccacgc tgtaatcgta
     1981 tatttatgta ctcctttaat ggaagaagca gaaacgttca aactctcgat gtttatttgc
     2041 cgacgggtaa atacagcggt cacctgattc agcaatccgg ctatattttc agaatgaact
     2101 ataatcgtat ataatgtctt atcactcata actttctaaa ttaaggatta acattccagc
     2161 aacatctgat tgactgaacc gcccggaggg gtcatcggga ggacattgcc ttcttctacc
     2221 acacaggctt cgagcaggaa cgccccgtct gtcgagagca tttcgtcgat ggccgctttc
     2281 aattcttccc gtgaaaagac acgtttggaa ggaatatcgt aggcggaagc gattttcatg
     2341 taatccggat tcagcatcgg agtaaatgaa taacggcgat taaagaacat agcctgccat
     2401 tggcgcacgt tgccgagata attgttgttc aggcagataa tcttcaccgg agctttctgt
     2461 tccatgatcg tacccagttc ctgaatgttc atttgcagtc cgccgtcacc cataaataca
     2521 catacagtgc ggtcgggacg gccgaaagta gctccgatag ctgccggaag gccaaaaccc
     2581 atcgtgccaa gtccacccga agtaacgata ctacgttccc tggtatattt aaagtagcgg
     2641 gcagagatca tctgattctg acctacatct gtcaccaata tggcttcgtg acgggtcgct
     2701 tcgcttaccg cacgcaccac ttcgcccata ctcagtgaat ccgttgcagg atgaagttcg
     2761 ggacgaatga ctttttcttc ctctaccgct tcatattcct tgaaactatc gacccactcg
     2821 gtgtgccggt tctttttcaa tagtccggtc acagcagcca gcgtcttttt gcagtcgccc
     2881 aaaacggcaa tatctacctt tacattctta tttacttccg ccggatcaat gtcaaaatgg
     2941 atcactttcg cttgtttggc gtaagtagct agattaccgg tcacacggtc gtcgaaacgc
     3001 ataccgacag caatcagtac atcacatttg ttagtattga tattcggtcc cagatttccg
     3061 tgcataccca gcattccttt attcaacgga tggtcggtag gcaatgcgga aagtccgagc
     3121 aaggtacaac ctgcgggcat atccgccttt tcgataaaga tacgcagttc ttcctgagcg
     3181 cttcccagtt ccactccctg tcctaccaag acaagcgggc gttcggcgtt attgatcagt
     3241 ttggcggcag cctttaccga ttcttcgtct gtatcgggaa ccggaacata gctgcggata
     3301 aactcctgct gcgtcggctc gtattttgtt ttttcaacct gcgcattctt ggcaaagtcg
     3361 agtaccaccg gaccgggacg accactactg gcaatgtaga aagcacgtgc tatcgcccag
     3421 gctacgtctt cggcacggcg aatctgatag ctccatttag cgattggctg agtgatacct
     3481 acgagatcga cttcctgaaa agcgtctgtt ccaagaaagc ctgttcccac ctgtcctgca
     3541 atgacaacga taggcgtact gtctatcatc gcatctgcaa tacctgtgat cgtattggtt
     3601 gctccggggc cgcttgtcac caagcaaaca ccgactttac ccgatacacg ggcgtagcct
     3661 tgtgccgcat gggcagctcc ctgttcatgg cgaaccaaga tatggttcaa tgtattttga
     3721 tggtcgtaca gggcatcgaa cgtaggcatg atggaaccgc cgggataacc gaaaatggta
     3781 gtcactccct gatgttccag agagcgcatc attgcctctg cgcctgttat taagtcctta
     3841 ctcatagttc tttaatggat aatggatgat tcataatgga taatgaagtg gatcagtcta
     3901 ttaatctcac tgctccctta tcggcagagc ttaccatgct ggcgtatgct ttcaggctct
     3961 tcggcacgta acggtcacgg gtgacgggag tcatcgggcg ggcagccagt tcttcatctg
     4021 ttagtcgcac gttaatcgtt cgggcaggaa tgtcgatttc gatgatatct ccatctacta
     4081 tttttcctat attacctccg gcagcggctt cgggagaaac gtgtccgata ctcaatccgg
     4141 aagttccacc actgaaacgt ccgtcggtaa tcaaggcaca ttctttgccg aggtgacggg
     4201 atttgatata agaagtcggg taaagcattt cctgcatacc gggaccgccc ttcggacctt
     4261 cgtgcgtgat gacgacaacg tcgccgctga cgactcggcc tccgaggatg ccttcacagg
     4321 ctgcttcttg tgagtcgaat actttggcag gtccggtaaa cttccagatg ctttcgtcta
     4381 cacccgccgt ttttactacg caaccgtcct gagcgatatt tcctttcagt accgccaaac
     4441 ctccgtcctt gctataggcg tgctccagat cacggataca tccgttcgcg cgatctttat
     4501 ctaattcctg ataataagct ccctgagaac caagtacgag attgaatctg tttcctgccg
     4561 cacttgaata tttgctcatt gctttttccg taacgttcgg gctggtaatt gaatattgat
     4621 cgatcgcttc cgccagcgac atgccatcca cacggagaac ggaagtatca atcagaccgc
     4681 cttttgccaa ctctgccagg atagcaatga tgccacccgc acggttaacg tcctgaatat
     4741 gatatttttg agtattcgga gcgactttac acaggcaggg tgtcttgcgt gacagcatat
     4801 cgatgtcgtc catcttgaaa tcgactcctg cctcatgtgc cacggccaac aggtgaagca
     4861 ccgtattggt agaaccgccc atcgcaatat ccagcgtcat ggcattgagg aatgcctgac
     4921 gggtagctat actgcgggga agtacacttt cgtcaccttc ttcataatat ttcattgcat
     4981 tttccacaat cagtttggca gcatcttcaa acagtttcgt acgattttcg tgcgtagcca
     5041 cgattgtgcc gtttcccgga agagccaagc cgatagcttc attcagacag ttcatcgagt
     5101 ttgccgtaaa cattccggaa caacatccgc aggtaggaca ggcattctgt tcgatattcg
     5161 ctacttcctg atcgcttaca ctgtcgtccg ccgatttaat catggcatcg atcaagtcca
     5221 gatgctgacc gttccactct ccggcttcca tcggtccgcc ggatacaaat acggtaggga
     5281 tattcaggcg catggcagcc atcagcatcc ctggggtaat cttatcgcag ttgctgatac
     5341 ataccactgc atccgccttg tgcgcattga ccatatattc tacgctgtcc gctatgatat
     5401 cacgggaagg aagcgagtaa agcattccgt catgtcccat agcgataccg tcatcaatag
     5461 caatcgtatt aaattccgca gcgaagcatc ccagcttctc aatttccgcc ttcaccaact
     5521 gcccgatttc atgcaggtgc acgtgtcccg gaacaaattg tgtaaacgaa ttgacgatag
     5581 cgataatggg ttttcccatc tgatttttct tcatgccgtt ggctgcccat aatgcgcggg
     5641 ctcccgccat gcgacggcct tgtgtactaa acgaactgcg taattgcttt ttcatttcaa
     5701 tctatctttt aattaaagag cctccctcac atcagtgaga aaggctccaa attctatctt
     5761 ttatggtacg aatacataca caaaaccttt ctcacgctct tgatggcacc accacgacgc
     5821 gaataatatg cagaactgct aggttaatag atgtatgtaa tatattcata tcttcttttc
     5881 tttattttcg tgctgcaaag gtaagggctt ttttattatc tccaaacaaa tcgaagaaaa
     5941 aaatcactaa aaagcgaata atcgtaagaa aagaacggta ataaacctaa attttatcac
     6001 ttaaaggttg aatttgcaac tatcagttag tagagaatga ctgtccattt ctgacaaaag
     6061 cgcttaataa tctgaaattt actccgtatg cacccggtag caagcaaatt attcgtatct
     6121 ttgtccaccc taaataaggg atttattaat tagaaactat aaatatcaga tggaaacagt
     6181 agaaaacaag tacatcaccg ttgcatataa gctatataca gtggaagatg gtgaaaaaga
     6241 attgttcgaa gaaacaaatg cagaacatcc ttttcagttc atttcaggat taggcacaac
     6301 gctcgaaagc ttcgagaacc agataacagc tctttctaag ggtgataaat tcgattttac
     6361 cattccggca gatgaagctt acggagccta cgatgagcaa catgtatttg atcttcctaa
     6421 aaatatcttt gaaatagatg gcaagttcga cagcgaacgc gtaacagaag gcagcattgt
     6481 acctttgatg accggagacg gtcaacgcgt aaacgccagc gtcgtagaaa tcaaaccgga
     6541 tgtagtagta gttgacctta accacccatt ggcaggcgct gacctgatct ttgaaggtga
     6601 agtaatcgaa agccgtcctg ctaccaacga agaaattcag gaactggtga agatgatgag
     6661 cggtgaaggt tgcggttgcg gatgcgacag ctgcggcagc gactgtggcg actgtggcga
     6721 tgactgcggt tgcgaaggcg gacactgcca ctaattttaa gtaataggta ataagtatta
     6781 agtattaatt ccatgcggat ataggcggaa gttaatactt aatacttttt ttatgccgtt
     6841 attccggcta ttacttatta cttgttactt attacctgtt acttattacc tgttaacatc
     6901 ctcctttgtg cgtcatgata tcaagcacca tcttatccgt ttcgttcatg gcctgcgagc
     6961 cgattcttgt caagttacga atgctttgat cgacatcttc gtcaataatg ccttctacag
     7021 aagtcacaca acggtcctcc attgccatca tagcagataa tacggctgtt gagactccgg
     7081 ttgttacttt gagtgcgcag ctcggttttg caccgtcgca aatcattccc gtcaggttgg
     7141 caatcatgtt ttgaacggca aaggctacct gattatagtt tccacccatc agccaggtga
     7201 ttccgcaact ggaacccgtg gcagctacta cacagccaca caaggcagag agacgtccca
     7261 aactttgttt aatatagatt acagtgagat gactcagcat taaggcgcga atcagttcct
     7321 cttcggtttt accattttct tcggcaaata cgacaacggg aagtgtggcg gatatgccct
     7381 gattgccact gccggagtta ctcatgacgg gaatcattgc accagccatt ctggcgtcgc
     7441 aagcggcgga agtataagat agtatatgag agaatacgct gtcacccatc actttatgtt
     7501 catacgttcc acggagcatc ttacctaaag aatgcccata attgccttta aaggcttgct
     7561 cggcggctgc tttgttcaga cgtgccgtat cgagaataaa acggatttca tccagagggg
     7621 atgtcagggc aaaatcatag actttgcgca gattcagttc cagtgaagcg tcttcttcct
     7681 cttcattggc agtctgttgc ttgtcaagca gtactttttc atccgtagct atatagacaa
     7741 aggtagtatg tccgccggca atcacagccg tcgctttttg gctgccggct gtgcagatta
     7801 cttcgatgta cagtttttcc gtaatatctt ctttgagaga aatacagatt cgcttctctg
     7861 cgataaacag tttgccttgt tctactgcct ccggtgtgca gtctctcaac acttccaatt
     7921 gatattccga tcggccgatc aacgctccca aggctacagc tataggaagt ccgaccatat
     7981 ctgtgccggg gataccgact cccattgcat tctttaatat attggcactc aataacactt
     8041 caatcttttc cggtttcatt cctaatgttt cggcagcttt agctacacaa agcgctaccg
     8101 caatgggttc cgtacaccct atcgccggaa tcacctcttt tttgatcaag tctattatct
     8161 gttttctttc cgattcaatc ataccctata aggctttagt ttccacaaaa gtagaaaatt
     8221 cttttttatc aaacatccat tagtgaacaa ataaaattgc agattgttat aaaatcttcc
     8281 aagaaccgaa ctttaacagt tagaatagta gaaaaatgaa agcaaaacac ggtattcttt
     8341 atttgctgct agccattttc tcttcttctt gcattcgcga agaagctccc aatgcagagg
     8401 cagacatact cagttgcaga ttgccgggag tagtcatgac aacgagtccg attatcacta
     8461 ataattccat caatatattt gtaggaccgg gaacggacat ttcatccctt gcacccgaat
     8521 ttacattgac tccgggagcc actatcgatc ctcccagtgg gacggctaga gatttccatt
     8581 cgcctcagca atataccgtt acggctgccg atggcttttg gaagaagaag tacaccgtat
     8641 ccgttattga tacggaactt gctactattt acaattttga ggatacgctc ggcggacaga
     8701 aatactacat cttcgtagaa cgggaaggag aaaaagtggt gatggaatgg gccagcggaa
     8761 acgcaggtta tgcaatgacc ggagttccca agacagccga cgactatccg acttttcagt
     8821 ttgcaaacgg aaaaaccgga aaatgcctgt ccttagtaac ccgcagtacc ggattcttcg
     8881 gtagcattat gggaatgcct atcgcagccg ggaacctgtt tatcggctct tttgatgtag
     8941 gaaatgcaat gagcaatcca ctgaaagcga ccaaattcgg tctgcctttc cggcatatac
     9001 caacttatct ggcaggctat tacaagtata aagccggaga tcagtttaca gaaggcggca
     9061 aacccgtcag tggcaaacgg gatatatgcg atatttatgc catcatgtat gagaccagtg
     9121 aatctgtgcc gactcttgac ggaacgaatg ctttcaccag tcccaacctg gtttcaatag
     9181 cacgcattga cgacgccaaa gagacggacg agtggacata ctttaaactt cccttccata
     9241 tgttatccgg aaaatacata gataaagaga agctaacagc aggcaagtat aatgtagcta
     9301 tcgtattcac ttccagcctg gaaggagatc attttaacgg agctatcgga agtacattgt
     9361 tgattgatga agtcgaacta atctatcgct cggaagactg attccattcg accaacgatc
     9421 tgatagcagc tatggaaggc agaacagagc aactataatg aaataactaa tgatttaata
     9481 ataatgaaaa gatgaaaatc cattcctata tattcagttt actcgcctgt ctggtgatag
     9541 ccctccccgg ctattcacag gttgacagaa acgaaacact tattcgctcc gctcttcacg
     9601 gactggaata tgaaatcaaa gcagggttca gcatcggcgg tacagccccg ctcccgctgc
     9661 ctgtcgaaat ccgttcgatt gacggctaca acccaacgct ggctatcagc atcggaggag
     9721 aagtaaccaa atggtttgcc gttcaaaaca agctcggagt cattgtaggg ctgcggctgg
     9781 agaataaagc catgacaacg gaagccaccg tcaaaaacta taatatggaa atcctcggac
     9841 agggaggaga aagaatcagc ggtgtctgga caggaggagt caaaaccaaa gtccacactt
     9901 ccggactgac aattcctcta atggctactt acaagttgag caaccgttgg aatattaaag
     9961 ccggacctta tttttcgtat ctgctttcaa gagaattttc ggggcacgta tatgaaggat
    10021 acctgcgtga aggcgacccc gtaggcccca aagtcgaatt tacggatggt aaaatcgcta
    10081 cttatgactt ctcggacgac ctgagacatt ttcagtgggg cctgcaaata ggagccggat
    10141 ggagagcatt caaacatctc aatatatatg cagacctcac ctggggattg aatgatatct
    10201 tcagaaatga ctttcagacc attacttttg ctatgtatcc gatctacttg aatatcggat
    10261 tcggatatgc tttctagctg accaaagacg gattaatcct taccggattc ctccacctgc
    10321 ttcacaccgg agaaagcaac tttcacggtc tgcttcaatg caggtacttt tacctgaata
    10381 ttcattgtag catttccact ttgcaccgtt ccttctatac tggtggcaca ggtacccaaa
    10441 gcagcggcat ccccctgaaa agtaaggtct tgctgtccgg tgaaagtcga agcgtccgtt
    10501 tcctttttca ctgcacactt gtctattacg atatcgccga actttaatat gtttccgttt
    10561 ataaacagtt caaattcctt cagttccatc tttacttccg tatcactgac ctgagagaaa
    10621 gtaataaact tcggaagtcc gtcggcaatc acaacttcct ggtcggagcc atcgggcagc
    10681 attgaaatat cgagatttcc ccaatacgtt cccaccacat cgggagcagt caccacagcc
    10741 tcttcttccg gaggagtcgt ttcatcattg accgtattat catcatcact gctacaagcc
    10801 gtcaaaagag agacagagca tatcaatgcc cacaaataca atagattctt tttcataatt
    10861 ttcgggttta gttattaaat aatcgtcatt tataaactaa aaagaggaaa aaaggttcaa
    10921 tttgcttcct tttccgaaga tattttgaat tcacaacctt cttatcgaaa actttgttat
    10981 atttgcatag agtaatttta aaaaagccac aactatgttt aattcatttg gcaacatctt
    11041 tcggctcacc agcttcggcg agtctcatgg aaaaggagtt gggggagtaa ttgacggatt
    11101 tccttccgga atcacaatcg acgaagaatt tgtacaacaa gaactaaatc gacgccgtcc
    11161 gggacaatcc atcctcacca caccacgcaa ggaagcggat aaagtggagt ttctttcagg
    11221 catcttcgaa ggcaaatcaa ccggatgtcc tatcggattt atcgtttgga acgagaatca
    11281 acattccaat gactacaata acctgaaaga ggtataccgc ccttcacatg cggattacac
    11341 ctacaaagtg aagtacggca tccgtgatca tcgcggtggc ggacgttctt ctgcccgcga
    11401 gactatttca cgcgtagtag ccggcgcatt ggctaaatta gcccttcgcc agttaggaat
    11461 cagcatcaca gcttatacat cgcaagtcgg tgccatcaaa ttggaaggca cttattccga
    11521 ctatgatctc gacctgatcg aaacaaacga tgtacgttgt ccggaccctg aaaaggcgaa
    11581 ggaaatggca gaccttatat ataaggtaaa aggcgaaggc gataccatcg gaggtacgct
    11641 gacctgtgtc atcaaaggat gtcctatcgg attggggcaa cccgtgttcg gcaaactgca
    11701 cgccgccttg ggcaacgcca tgctcagtat caatgccgcc aaagccttcg aatatggaga
    11761 aggattcaag ggactgaaga tgaaaggctc cgagcagaac gacgtattct tcaacaacaa
    11821 cggacggatt gaaacgcata ccaaccactc cggaggtatt cagggaggaa tcagtaacgg
    11881 acaggatatt tacttccgtg tagtattcaa accgattgct accctgctga tggagcagga
    11941 aacggtgaac atcgacggcg tagatacgac actgaaagcc cgcggacgtc atgacgcctg
    12001 tgtactgcca cgtgccgtac ctatcgtaga agcaatggct gccatgacca tccttgatta
    12061 ttatctgttg gataagacaa cgcagcttta ataagtatca atatgtcaat ctacccatgt
    12121 gccaatacct gcactaaaaa tctgtcaggc tattggcaca taggctaaat aaccgccagt
    12181 aaactattca ttatgaacga aattcaaaaa tatatcgcag cgaacgaacc gaagattatg
    12241 gaggacctgt tcagcctcat ccgtattccc agtatcagcg ccctgccgga acatcacgac
    12301 gatatgctgg cttgcgccca acgctgggca caactactgc tcgaagccgg agtggatgaa
    12361 gcattggtga tgccttccaa gggtaacccg attgttttcg cacaaaagat cgttgacccg
    12421 aatgccaaaa cagtattggt ctacgcccac tacgacgtaa tgcctgccga accgctggaa
    12481 ctgtggaaaa gccagccctt cgaacccgaa gtacgggacg gatacatctg ggcacgcgga
    12541 gcggatgatg acaaaggaca atcctttatc caggtcaaag ccttcgaata tctcgtcaag
    12601 aacgaactgc tgaaaaataa cgtcaagttt atcttcgaag gagaagagga aatcggctct
    12661 cccagcctgg aagccttctg cgaagagcat aaagagctgt tgaaagcaga cgttatcctg
    12721 gtttcggata ccagcatgct gggtgccgaa cttccatccc tcaccaccgg tctgcgcgga
    12781 ctggcttact gggaaataga agtgaccgga ccgaaccgtg acctgcattc gggacacttc
    12841 ggaggtgcgg tagctaatcc gatcaatgtg ctttgcgaaa taatcagcaa agtaacagat
    12901 aaagacggaa gaatcaccgt ccccggattc tacgatgacg tagaagaagt accgcaagca
    12961 gaacgggaaa tgatcgccca tattccgttc gatgagaaga aatacaaaga agccatcgga
    13021 gtgaaagaac tcttcggaga aaagggatac agcacactgg aacgcaacag ttgccgcccg
    13081 tctttcgatg tatgcggcat ttggggagga tatacaggtg aaggctccaa gacagtcctt
    13141 ccctcgaaag cgtatgcgaa agtttcctgc cgactggttg cgcatcagga tcatcacaag
    13201 atttcgcaga tgtttgcaga ttatatctta caaatggctc ccgacaccgt acaggtaaaa
    13261 gtaaccccaa tgcacggagg acagggatat gtctgcccga tttcccttcc tgcctatcag
    13321 gctgcggaaa aaggttttga gatagctttc ggcaaaaaac cgctggcagt acgtcgtggc
    13381 ggaagtattc ctatcatttc gacattcgaa caggtattag gaaccaaaac cgtattgatg
    13441 ggcttcggac ttgaatcgga tgcgatccat tcacccaacg aaaacttctc gctggacata
    13501 ttccggaaag gaatagaggc agtgattgag ttccatcagg aatatgcgaa aagataaagg
    13561 ctgcctatag ccgcacgcag gacacgaaga taaaaggaga acggtagaca agcggataaa
    13621 tcctttgcct accgttcctt tttattcaaa aaaagacctc ttaccacata actaactatc
    13681 gactacatca ccggagtttc gaaaaggaaa gtaaatgatt gactatcctt caaatccttc
    13741 acggcatctc ctgcgtaaat ttctcctttg gtcaaggaca gtttcttcac cccagccttc
    13801 ggactaaaat caatcttctt caaatccagc caaaacaggt tcggagttaa agtagactca
    13861 aagtaataca ctttattctt ctgatcggaa acggaacgcc agcgagtaga agaaatgtga
    13921 ggcttctccg gtgtattgat accaaacgga acggagacat tgcgcatcac actcagcaca
    13981 ctggggacag ctatctttgc atcggcagtc tgcggaatgg cgtgaatgta gaaagaggca
    14041 cgcacaaaac ggtcgctcga acggttcgtt cccggcaaca tctgcaatcc acccacttct
    14101 ttccagtaat cattgacagc caactgcaat tcataacgcg gagaattggt catcacctga
    14161 tattctttcc cctcatggat actcagtttg ccatccagat attcgatcac tgccgtgttg
    14221 cctgtttcat cggtaatagc catgtgtaaa gtagattccg gtcccccgtt cggcatacgg
    14281 ggagcgtcaa tacggaaagt ctcttttttc atttcatcta ccgcctcacg caccgttgca
    14341 aaattgtcaa gcacatattg agtccagata ctgattccca ttgccggacg ggtatctccg
    14401 ggaagtgaat aaacagattc cggcaagaag agcaagcttg ccaccagtcc tttttcattc
    14461 attccgtcac aagtacctat atcatagcct gttgcaatta cgcttccata tttggaagtc
    14521 cagtttactg ttttttcttt attgtgtccc gcacgctgca ttccacgtgg aaacacatag
    14581 atatttgaca taatgtcttc tttccagtcc atcgtgcgac cagtgaccac cattcggtcc
    14641 ggccccagat atacggcacg cgtacatgct cccgccggct gtatgcccat caaagagacg
    14701 gcagctaaca ccaatgcaac acccgtaagt tttttcttca tattacttcc aaattaaata
    14761 gttgatactc ttatatctat aataacaaat atacaacgta tattgcttga gagagagaaa
    14821 aatttaaggg aaaaaaggga atttattcag aaaaaatctt atccgctctt atttgagtta
    14881 aaaaagcctg cggatggaag gaaacattac acattatttg cttttcaaat gggatttcat
    14941 tatttttgta cataacctat cataaaaact aaggagggca aatgcgtatg agacaaaaag
    15001 ttagcatatc acagcttcca attcgtttgg gaatctttct tttgctgtat tttgttccgc
    15061 aatcactctc tgcgcaagaa aacaacgaca gtacgcacat acttcgtaac ggtgcatcca
    15121 taacgccgga cgacgtacta aaacaggcca acattaactt gtttccagaa aagagcacta
    15181 catattcttt atattcaccc ggacagttgg agcatatacc ccgcttttca ctcaaaaggg
    15241 atatttccct accttatcag accaatcctt ccctactctt ccgaggtgat tacagtacgg
    15301 gcggggtatt gcatcaattc gatcgtggag cactgttcgg ttccggaagt cagacaagta
    15361 tggcaggcat cgggcgtttc aacagtgctt cactaggtta tcagcatatt ttcaatgagc
    15421 aattcgagtt acaagtccgt gccaatgcgc tgaaggtcaa catgtcccac atcaccggac
    15481 aggctttcag cacttcgggc gccttccttt accatccttc cgaccgtgtc accttgaaag
    15541 tcttcggatc atacgacatc agaaactctt acggaatgag cacccatagc tacggagct
//
