LOCUS       c00001_gnlPro..        16542 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LFGCPKNM_1.
ACCESSION   c00001_gnlPro..
VERSION     c00001_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 17:33:25
            Original ID  :: gnl|Prokka|LFGCPKNM_1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16542
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16542
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3144:6702](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3145..6702
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16542
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16542
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(573..1727)
                     /locus_tag="ctg1_1"
                     /transl_table=11
                     /translation="MALASGETNYMAPASARQMASDLALLPMWYAEAGSAVLAPSAYNA
                     DFLKTKSELLGMDVALLTEPEVADGKDWKFSPWGWDPALRKRLMTLGAGQTELPSADYM
                     NILREHSHRLQAVKLLPGLRLNEYFCGESFYLSTLAECSAFVEGREACLLKAPLSGSGK
                     GLNWCKGIFTTFISGWCARVAASQGGVVGEPIYNKVEDFAMEFYADGRGRVVFAGYSVF
                     HTGGSGMYAGNDLLSDEKILQKLSAYVPQEEFIRLRTRLEEELSALFGGFYHGYLGVDM
                     MICHFPDEAPVYRIHPCVEINLRMNMGVVAWLLTDRYLAADAEGVFRIDYYPLAGQALE
                     EHRQMSASFPLSVENNRVCAGYLPLVPVTPQSRYRAFLLLTLPQ"
     CDS             1907..3112
                     /locus_tag="ctg1_2"
                     /transl_table=11
                     /translation="LPAEKQRNEMESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGI
                     KGTRGVGKTTFLLQYAKEKFGNDRSCLFINMNNFYFSGHSIVDFANEFQKRGGKVLLID
                     QVFKHPEWSKELRMCYDRFPNLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREFL
                     NLQTGMKFRAYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENL
                     LKTMNMMVEVDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDIQTSRATVMN
                     YIKYLADARLINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFANSLW
                     KDHKVHKGDKNVSFMVDEVMPFKICQEGAKIKNNPNVTYALHKAEIGRGNQIPLWMFGF
                     LY"
     CDS             3145..6702
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_3"
                     /sec_met_domain="PFOR_II (E-value: 6.1e-19, bitscore: 57.9,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 7.1e-83, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 7.8e-32, bitscore: 100.3,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.4e-12, bitscore:
                     37.3, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 2.4e-12, bitscore: 37.3,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 4.6e-08, bitscore: 22.4,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 2.5e-05, bitscore: 14.4,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 1.2e-25, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMKPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDYLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKTIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQILSVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIAMEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLTVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNAENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKVFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAQAENWTYCAENVKTKQHLVDIKANVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTTNENGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARLVKVMNEAIAADCTPAEVKELFAEWINNMLDADKTKE
                     LAAKIIPVVEANKDKCNHCKQIAELQQYLVKRSQWIIGGDGASYDIGYGGLDHVIASGK
                     DVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQIA
                     MGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLWR
                     YNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPAEAEELFKAAEENAKW
                     RYNSYKRLARENWGADTAE"
     CDS             6827..7015
                     /locus_tag="ctg1_4"
                     /transl_table=11
                     /translation="MIGFVIWIIGLILTFRAAIEIWNINAAVEKRLIAIVLIVLTSWLG
                     LLFYYFYGKERMAGWLK"
     CDS             complement(7026..7886)
                     /locus_tag="ctg1_5"
                     /transl_table=11
                     /translation="MNKIKMIAAMFIAGILLTFVSCGDNGKSKKISIAYANWSEGIAMT
                     NLAKAIFEDQGYDVKLLNADLAPIFTSISRKKADVFMDVWMPVTMEDYMKQYGDKLEVI
                     GDIYDGARIGLVIPDYVTINSIEELNAEKERFSGQIVGIDAGAGIMKATDQAIKDYGLD
                     YKLMTSSGPAMTASLKKAIDKKDWIVVTGWTPHWMFDRFKLKVLQDPKLIYGNTESIHT
                     IAWKGFSEKDPFAAELLGNIRLTDAEISSLMTALEEAQTTERQAARQWMEEHQELVNSW
                     IPEKD"
     CDS             complement(7914..8744)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 91.7; E-value: 1.6e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_6"
                     /sec_met_domain="BPD_transp_1 (E-value: 2.9e-29, bitscore:
                     91.7, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIETAINWLTEHFASFFDALSMGIGGFIDGFQHVLFGIP
                     FYITIAVLAALAWFKSGKGTAVFTLLGLLLIYGMGFWEETMQTLALVLSSTCLALLLGV
                     PLGIWTANSDRCNKIMRPVLDFMQTMPAFVYLIPAVLFFGLGTVPGAFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATPWQLLYKVQLPLALPTILTGINQTIMMSLSMVVIA
                     AMISAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIVLDRITQGMADNRKSKKK"
     CDS             complement(8741..9967)
                     /locus_tag="ctg1_7"
                     /transl_table=11
                     /translation="MSKIEIKDLYLVFGNEKQKALKMLKEGKTKSEILKATGCTVAVKD
                     ANLSINEGEIFVIMGLSGSGKSTLLRCINRLIRPTSGEVIINGTDIAKVSDKELLQIRR
                     KELAMVFQNFGLLPHRSVLHNIAFGLELQGVKKGEREQKAMESMQLVGLKGYENQMVSE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLTLQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEIVQIGTSEEILTEPANAYVERFVENVDRSKIITASSVMVD
                     KPIVARLKKEGPEVLIRKMRERNLTVLPVVDSNNLLVGEVRLNDLLKLRKEQIRSIESV
                     VRHEVHSVLGDTVLEDILPLMTKTNSPIWVVNENREFEGVVPLSSLIIEVTGKDKEEIN
                     EIIQNAIEL"
     CDS             10440..11726
                     /locus_tag="ctg1_8"
                     /transl_table=11
                     /translation="MFNRAITIFLGKDNCHYTTKEKQTGTATLDDKSQVQFLSKKNPKM
                     PFFYSRRNLYMIGFLLAFIVTLLEFIRGRHQNFMVFSDATQFFWQGISPYTTEFVEAHG
                     RYFLYSPVFTVLFAPFAYLPAWLGPFAWNLFNYSLFFMAIFTLPQQFTQQQKCRMFLFL
                     LLILGQSLLSFQYNITVAYLFLFAYTLLEKDRGFLAVLLIMISGCTKVYGIFELALLLC
                     YPHVWRNFGYAVTMGIVLLALPLIKIAPADLLPYYEEWCHSLAVHQSAGAYDSFFYARP
                     IAAWTLPHFRALQIGMLGLLTLLFLGNFRKWSSFAFRAQALGILMGWVVLLSDSAEKHT
                     YIIALAGFMLWYWSRPTRTATDKILFWCCFVLLCIVPIDIFVPIPIRDFITRTLWLHVW
                     VFFIVWIRMIWLTFLASFIHPRATNVLSD"
     CDS             complement(11689..12021)
                     /locus_tag="ctg1_9"
                     /transl_table=11
                     /translation="MKDYKVDKESFSESFRKEVYEVVSQIPVGKVSTYGGIALLLGAPQ
                     CSRMVGRALKEVPDELSIPCHRVVNSTGRLVPGWVEQKQLLLAEEVSFKANGCVNLKEH
                     LWHVDE"
     CDS             complement(12049..14802)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 64.3; E-value: 4.2e-20)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_10"
                     /sec_met_domain="Peripla_BP_1 (E-value: 7.4e-21, bitscore:
                     64.3, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTMRYLKWMLVLFGLIGMTACRQDTPRFRIGVAQCSDDSWRHKM
                     NDEILREAMFYNGVSVEIRSAGDDNSKQAEDVHYFMDEGVDLLIISANEAAPMTPIVEE
                     AYQKGIPVILVDRKILSDKYTAYIGADNYEIGRSVGNYIASSLKGKGNIVELTGLSGST
                     PAMERHQGFMAAISKFPDIKLIDKADAAWERGPAEIEMDSMLRRHPKIDAVYAHNDRIA
                     PGAYQAAKMAGREKEMIFVGIDALPGKGNGLELVLDSVLDATFIYPTNGDKVLQLAMDI
                     LEKKPYPKETVMNTAVVDRTNAHVMQLQTTHISELDKKIETLNGRIGGYLSQVATQQVV
                     LYGSLIILLLVAGLLLVVYKSLRSKNRLNKELFKQKQQLEEQRDKLEEQRDQLIQLSHQ
                     LEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADKTLSGDQHRMLMLIQRNVNILLR
                     LVNQILDFRKYENGKMEYTPVTVDVLSSFEGWNESFQAAARKKHIHFSFDSMPDTDYHT
                     LADMEKLERIYFNLLSNAFKFTPENGKIAVRLSSLSKEDKRWIRFTVANTGSMISAEHI
                     RNVFDRFYKIDMHHTGSGIGLALVKAFVEMHGGMISVESDEKQGTVFTVELPVQSCEAV
                     AAEPDTTLVSADSRTTDVLLAEEEELEKGYDSSKPSVLIIDDNEDIRSYVHTLLHTDYT
                     VIEAADGSEGIRKAMKYVPDLIISDVMMPGIDGIECCRRLKSELQTCHIPVILLTACSL
                     DEQRIQGYDGGADSYISKPFSSQLLLARVRNLIDSHRRLKQFFGDGQTLAKEDVCDMDK
                     DFVERFKSLIEEKMGDSGLNVEDLGKDMGLSRVQLYRKIKSLTNYSPNELLRIARLKKA
                     ASLLASSDMTVAEIGYEVGFSSPSYFAKCYKEQFGESPTDFLKRKG"
     CDS             complement(15135..16361)
                     /locus_tag="ctg1_11"
                     /transl_table=11
                     /translation="MFFFLIVPLFLALFYKPIAYLCGRFLNNKSKRENYFMKHISNFLR
                     SKSWNVFLFLYLALPLFAQKEYKIDQVSVVNVGDGRLLFQELKTEKALNGEHRIIDGYH
                     SAYVLASFKDGFYDGGYKEYVDNILITEGSYKEGRKDGLFKINSKFDGKLKEEKSYKEG
                     KLDGTSKSYFTTGKVESERNFRMGKEHGKQLSYESDGTLRKEHNYKDGKQVGKQYTFLK
                     GTYDLYETVYFNEEGFQDGEYSSVFTFGSPRILGSYKNGKKNGRWTTFAESGDTLMIET
                     YLDGKEDGLHVSFANGSGVRQKEYYMKNDRKDGLYREYNLENGELRYEATYQAGRLHGK
                     ERRLIVSNRFDYWETSTYVNGRQNGPFEARYVKNDQLRECGEYKNGHRVGRWKRYTIDG
                     KLEKEWDEN"
ORIGIN
        1 gtaaactaat tcagttataa caaacgaagt tgtcaactaa aaccagtaca catcaccaat
       61 tccaatttag cagtatcttc aaagagtttc cattgcttga aaccagagtt tcatcggtgt
      121 gaaactgtag tttcatcggt gagaaactag agtttcatac gcttgaaact ttagttccaa
      181 acgctcgaaa ctatctgaaa ctactgttga tttgattgac ttaaccgcat gttccaatca
      241 cattgaacgc atcagctact tcaatagtac tgctctctct gaaaacatta aatcatatat
      301 cagtcaataa tacataaatt atcagtcctt aatacttgat ttctcaatta ttaatatctg
      361 agaaatcaaa cgttaacagt tgagatatca gatattaaca tcctgtaaat caaagaataa
      421 cacagtaaaa acagtattta tcaggacgat gcagagtgag agcaagtcct tgctctcact
      481 ctgctaccac tggatctcta acagctaaaa catcgatgaa taaagggata cagacgaact
      541 gttagagcat gagagcaaaa gcactatctt tttcactggg ggagagtaag caaaagaaac
      601 gcacgatacc ggctttgagg cgtcaccggt actaacggca aatatccggc acacacccga
      661 ttattctcta cggacaaagg gaacgaagcc gacatctgcc gatgttcctc caaagcctga
      721 ccggctaaag gataataatc aatccgaaaa actccttccg catccgcagc caaataacga
      781 tccgtcaaga gccatgccac cacccccata ttcattcgca gattaatttc gacacaagga
      841 tgaatccggt aaacaggcgc ttcatccgga aaatgacaaa tcatcatatc cactcccaag
      901 tatccatgat aaaagccacc gaacaaagct gacaattctt cttccaaacg agtccgcagc
      961 ctgataaatt cttcttgtgg cacataagcc gatagtttct gcagaatctt ctcgtcagac
     1021 agcaagtcat tccctgcata catcccactc ccacccgtgt ggaagaccga atatccggca
     1081 aaaacaaccc ttcctctccc gtcagcataa aactccatag cgaaatcttc caccttatta
     1141 tatataggtt cgcctaccac cccaccctga gaagcagcga cacgggcaca ccaaccggaa
     1201 ataaaagtag taaatatgcc tttacaccaa ttcaatcctt tcccgcttcc ggaaagcgga
     1261 gcttttaaca agcacgcttc ccgcccttcg acgaacgcac tgcactccgc caaagtactc
     1321 aaataaaaag attctccaca gaagtattca ttcaaccgca acccaggcaa caactttacc
     1381 gcctgcagac gatgcgaatg ctctctcaga atattcatat aatccgcaga aggcagctcc
     1441 gtctgacctg cccccaatgt catcaaacgc ttccgcaaag cagggtccca accccacgga
     1501 gagaacttcc agtctttacc gtcagccact tccggttccg tcaacaaggc cacatccatg
     1561 cccaaaagtt cactctttgt tttcaggaag tccgcattat aagcagacgg tgcaagcacc
     1621 gcacttcccg cttcggcata ccacatagga agcaacgcca ggtcactcgc catctgtcgg
     1681 gcggaagccg gcgccatata gttcgtctca ccgcttgcca acgccatatc atgctccgga
     1741 ttgaatatat aaacaggtct tttcgtcatg tcaaagatgg attcaacaca ttattctgca
     1801 aatatataca ggaaataatc aggaacttac acaataaaga gaaacttata aattaaagca
     1861 catttttgct atctctactt tgcaaatcct aaaaaaagca ctatatttgc cagccgaaaa
     1921 acaaagaaac gaaatggaat cattctatcg cacacacgcc tacctcgttg agcacaccaa
     1981 tgcccccgtt cgccgcgatc ttatggacga gatcgactgg agcgaccgcc tgattggtat
     2041 caaagggaca cgtggcgtag gaaaaaccac tttccttctc caatacgcca aagagaaatt
     2101 cgggaacgac cgttcctgtc tgttcatcaa catgaacaac ttctatttct cgggccacag
     2161 cattgtagac ttcgccaacg aatttcagaa acgtggcgga aaagtattgt tgatcgacca
     2221 ggtgttcaaa catccggaat ggagcaaaga gttacgcatg tgttacgacc gttttcctaa
     2281 cctgaaaatt gtcttcaccg gctcgtccgt gatgcgactg aaagaagaaa atcttgaatt
     2341 acgtgatatc gccaagagct ataacctgcg tggattctct ttccgtgaat tcctaaactt
     2401 gcaaacaggc atgaaattca gggcatatag cctcgaagaa attcttagca ctcacgaaca
     2461 gattgccaaa ggagtactct ccaaagttcg tccgttggac tattttcagg attacctgca
     2521 ccacggattc tatccgttct tccttgaaaa acgtaacttt tcggagaatc tgctgaaaac
     2581 gatgaacatg atggtggaag tagatatact tctcatcaaa caaattgaac tgaaatatct
     2641 ttcaaagata aaaaaattgc tatatttgct cgctgtcgat gggccgaagg ctccaaatgt
     2701 gagccaactg gcaagcgaca tacagacatc tcgcgccacg gtgatgaact atatcaagta
     2761 tctggcagat gcgcgactca ttaatctggt ttatccgaaa ggggaagaat tccctaaaaa
     2821 accttcgaag ataatgatgc acaactccaa cctgatgtat tccatctatc cggtgaaagt
     2881 ggaagagcag gatgtgctcg acacattctt tgcaaattct ttatggaaag accataaggt
     2941 acataaagga gataaaaacg tctcttttat ggtagacgaa gtaatgccgt tcaaaatttg
     3001 ccaggaaggc gcaaagatca agaacaatcc gaatgtaacg tacgcgttgc ataaggctga
     3061 aataggtcgg ggcaaccaga tacctctctg gatgttcggc tttttatatt aaaagattta
     3121 tttacttaaa tatttaattt agttatgact aaacagaaga aattcatcac ttgtgatggt
     3181 aaccaggctg cagcgcatat ctcgtatatg ttctctgaag tagcagctat ctaccccatc
     3241 actccttctt cgactatggc tgagtacgta gacgaatggg ctgccgcagg acgtaagaac
     3301 atcttcggcg aaacagtatt ggtacaggaa atgcaatctg aaggtggtgc tgccggtgca
     3361 gttcacggtt ctcttcaggc tggtgcgttg actactactt acactgcttc ccagggtctt
     3421 ctcctgatga tccctaacat gtacaaaatt gccggtgagt tcttgccttg cgtattccat
     3481 gtatctgctc gtacattggc ttctcacgca ttgtgtatct tcggtgacca ccaagacgta
     3541 atgtcagctc gtcagactgg ctttgctatg ttggctgaag gctctgtaca ggaagttatg
     3601 gatttggctg gtgttgctca cttggctacc atcaaatctc gcgttccgtt catgaacttc
     3661 ttcgatggtt tccgtacatc tcacgaaatc caaaagattg aaatgttgga aaatgatgat
     3721 cttgctccgc tgatcgacca agaagctttg gctgaattcc gtgcccgcgc actgaacccg
     3781 atgaaaccgg tagctcgtgg tatggctgaa aatcctgacc atttcttcca acatcgtgaa
     3841 tcatgcaaca actactacga agcagttcct gctatcgtag aagaatacat gaatgaaatt
     3901 tctaagatca caggtcgtaa atacggtttg ttcgattact atggtgcaga agatgcagaa
     3961 cgcgtaatta tcgctatggg ttctgtaaca gaagctgccc gcgaagctat cgactacctg
     4021 gtagcaaacg gcgaaaaagt gggtatggtt gccgtacacc tgtatcgtcc gttctctgct
     4081 aaacacttcc tggctgctgt acctaagact gctaagacta tcgcagttct tgaccgtact
     4141 aaagaaccgg gtgctaacgg cgaacctctt taccttgacg ttaaagactg cttctacggt
     4201 gcagaaaatg ctccagttat cgttggcggt cgctacggtt tgggttcaaa agatactact
     4261 cctgctcaaa tcctttcagt attcgaaaac ttggctatgc caatgccgaa gaaccacttc
     4321 actatcggta tcgtagacga tgttactttc acttctcttc ctcaaaaaga agaaatcgct
     4381 ttaggcggcg aaggtatgtt cgaagctaaa ttctacggtt tgggtgctga cggtacagta
     4441 ggtgctaaca agaactctgt aaagattatc ggtgacaaca ctgacaaaca ctgccaggct
     4501 tacttctctt atgactctaa gaagtcgggt ggtttcactt gttctcactt gcgtttcggt
     4561 gatactccga tccgttctac ttatttggta aatactccga acttcgttgc ttgtcacgtt
     4621 caggcttacc tgcacatgta cgacgtaaca cgtggtttgc gtaagaacgg ttctttcttg
     4681 ctgaatacca tctgggaagg cgaagaactg gctaagaacc tgcctaacaa ggtgaagaaa
     4741 tactttgcac agaacaacat ctctgtatac tatatcaacg caactcagat tgcaatggaa
     4801 attggtttgg gcaaccgtac caatacaatc cttcagtctg cattcttccg tatcacaggc
     4861 gtaatccctg tagatcaagc tgttgaacag atgaagaaat tcatcgttaa gtcttacggc
     4921 aagaagggtg aagacgttgt taacaagaac tacgctgctg tagaccgcgg tggtgaatac
     4981 aagactctga ctgtcgatcc tgcttgggct aacctgccgg atgatgcaaa agcagaaaac
     5041 aatgatcctg ctttcatcaa cgaagtagtt cgtccgatca atgcacagga cggtgacttg
     5101 ctgccggtat ctgcattcaa gggtatcgaa gacggtactt ggtatcaagg tacttccaaa
     5161 tacgaaaaac gtggtgtagc tgcattcgtt cccgaatgga atgctgaaaa ctgtattcag
     5221 tgtaacaagt gtgcttacgt ttgtcctcac gcttctatcc gtccgttcgt actcgatgct
     5281 gaagagcaga agggtgctaa gttcgaacaa ctgaaagcag taggtaaagt attcgacggt
     5341 atgacattcc gtatccaggt tgacgttctc gactgtctgg gttgcggtaa ctgtgctgac
     5401 atctgtccgg gtaatccgaa gaagggtggc aaagcattga caatgaaaca cctcgaaagc
     5461 caattggctc aagctgaaaa ctggacttac tgtgctgaaa acgtgaagac taaacaacat
     5521 cttgttgata tcaaggctaa cgtgaagaac tcacagttcg ctactccgtt gtttgagttc
     5581 tccggcgctt gctctggttg tggtgaaact ccatacgtga aattgatttc tcaattgttc
     5641 ggtgaccgtg aaatggttgc taacgctacc ggatgttctt ctatctactc tggttctgtt
     5701 ccttctactc cgtatactac aaacgaaaac ggacacggtc ctgcttgggc taactcactg
     5761 ttcgaagact tctgtgaatt cggtttgggt atggaattgg ctaacgaaaa gatgcgtgct
     5821 cgtctcgtga aagtgatgaa cgaggctatt gctgctgatt gcactcctgc tgaagtgaaa
     5881 gaactgttcg ctgaatggat caacaatatg ctggatgcgg acaagactaa ggaattggct
     5941 gctaagatca ttccggttgt tgaagctaac aaggataaat gtaaccactg caaacaaatc
     6001 gctgaactgc aacaatatct tgtaaaacgc agccagtgga tcattggtgg tgacggtgct
     6061 tcttacgata tcggttacgg tggtcttgac catgtaatcg cttccggtaa ggacgttaac
     6121 atcctcgttc tggatactga agtttactct aacacaggtg gtcagtcttc taaagctact
     6181 ccggtaggtg ctatcgctaa gttcgcagct gctggtaagc gcgtacgtaa gaaagacctc
     6241 ggtctgatgg ctactactta cggttatgta tatgttgcac agatcgctat gggtgctgac
     6301 caagctcaaa ctctgaaagc tatccgtgaa gctgaagcat atccgggacc atctttgatt
     6361 atcgcttatg ctccgtgtat caaccacggt ctgaaagcag gtatgggtaa gagccaggaa
     6421 gaagaagaaa aggctgttaa gtgcggttac tggcacttgt ggcgttacaa cccggctttg
     6481 gaagaagaag gcaagaaccc attccaattg gatagcaaag aaccgaactg ggaagatttc
     6541 caaggtttct tgaagggtga agttcgttac gcttctgtaa tgaaacaata tcctgctgaa
     6601 gctgaagaac tgtttaaagc tgctgaagaa aacgctaaat ggcgttacaa cagctacaaa
     6661 cgtcttgcca gagaaaactg gggagctgat acagctgaat aataagtaga aatactttat
     6721 acataataaa aggcaggaat cctggaaaca gattcctgcc ttttttgttt atatcttaga
     6781 agtaacgatt acttctcacg aagatattca ttaaaactct aaagatatga tcggatttgt
     6841 tatttggatt atcggtttga tactgacttt cagagctgcc atagagattt ggaatataaa
     6901 tgcggctgta gagaaaagac ttatagcgat tgtattaatc gttcttacca gctggctggg
     6961 actacttttc tactacttct atggtaaaga aagaatggca ggatggttga agtagtgttt
     7021 gcatatcaat ctttctcagg aatccaactg tttaccagtt cctgatgttc ttccatccat
     7081 tgacgggcag cctgtctttc cgttgtctgc gcctcttcca gagcagtcat taaagagctg
     7141 atttccgcat ctgtcagacg aatgttgccc aaaagttcgg cagcaaaagg gtctttctcg
     7201 ctaaaacctt tccatgctat ggtatgaatg gattccgtat ttccatatat cagcttcggg
     7261 tcctgaagaa ctttcagctt gaaacggtcg aacatccagt gaggcgtcca tcccgtcacg
     7321 acaatccagt ctttcttatc aatcgctttc tttagggaag cagtcatggc aggtccgctc
     7381 gaagtcatca gtttataatc caatccatag tctttgatgg cctgatcggt agctttcata
     7441 ataccggctc cggcatcaat accgacaatc tgaccggaga aacgttcctt ttccgcgttc
     7501 agttcttcga ttgagttgat cgtaacgtaa tccggaatca ccagcccgat acgggcacca
     7561 tcataaatat ccccgataac ttcgagttta tccccgtatt gtttcatata atcttccata
     7621 gtgacaggca tccagacatc cataaatacg tctgctttct tacgggagat agaggtaaat
     7681 ataggtgcaa ggtcggcatt cagcaacttt acatcgtacc cctgatcttc aaaaatcgct
     7741 ttggcaaggt ttgtcattgc aataccttcc gaccagttgg cataagcgat acttatcttc
     7801 ttactctttc cgttgtctcc gcaggaaacg aaggttaaga gtatgccggc aataaacatt
     7861 gccgcaatca tttttatctt attcattgat tattcctttc tttggtgtga ttcttatttc
     7921 tttttacttt ttctgttatc tgccataccc tgagtgatgc ggtccagcac gatcgccaat
     7981 atcacgactg cgataccgcc ttcaaatccg agtccgattt tcatttgggt gatacctttc
     8041 agcacgattt ctcccaaccc tcccgcagaa atcatggcgg caatcactac catcgaaagt
     8101 gacatcatga tcgtctgatt gattcccgtc agaatagtag gcaatgccaa aggcaattgc
     8161 accttataaa gaagctgcca gggagtagct ccaaaagaac gggaggcttc tactacattt
     8221 ttaggaacct gacgaatgcc cagaccagtc agacgaacca caggaggcat tgcaaagatg
     8281 atggtggcaa aagctcccgg cacagttccc aatccgaaga atagaacggc aggaatcaga
     8341 tagacaaagg caggcattgt ctgcataaag tcgaggacag ggcgcattat cttgttacaa
     8401 cgatcactgt tggcagtcca gattcccaac ggaacgccta aaagcaatgc cagacaagtg
     8461 gaagaaagta ccaatgccaa tgtctgcatc gtttcttccc aaaagcccat gccgtaaata
     8521 agcaataaac ccaagagggt aaatacggct gtccccttac ccgacttaaa ccaggcgagc
     8581 gcagccagca ctgcaattgt gatataaaaa ggtattccaa acagtacgtg ctgaaaaccg
     8641 tctatgaatc ctccgatccc catgctgaga gcatcaaaaa aggaagcaaa atgttctgtg
     8701 agccaattaa tggcagtctc tatatattgt ccgatattta tcataattct attgcgtttt
     8761 gaatgatttc attaatttct tctttatctt ttcccgttac ttcgatgatc aatgaggaaa
     8821 gtggcactac gccttcaaac tcccgattct catttacgac ccagattggc gagttcgttt
     8881 ttgtcatcaa cggaagaata tcttccagca ccgtatcacc cagcactgaa tgaacttcat
     8941 gccttactac ggactcgatg gagcggattt gctcttttcg tagtttcagc aagtcattca
     9001 accgcacctc tcctactaac agattattgg aatcgactac cggaagaacg gtcagattcc
     9061 gttcgcgcat cttacggatc agcacctccg ggccttcttt cttcaaacgt gccactatgg
     9121 gtttatctac cataacagag gaagctgtta taatcttgct tcgatctaca ttctccacaa
     9181 atcgttctac ataagcgttg gcaggttcgg tcaggatttc ttccgatgta ccgatttgta
     9241 caatttctcc atccttcatg atagcaatcc ggtcacccaa tttaatcgct tcactcaggt
     9301 cgtgagtaat aaagacaatc gtttttttca tcttcgactg caaagtcagc agttcatcct
     9361 gcatctgcac acggatcaaa ggatcgagtg ccgagaaggc ctcatccatc aacaggactt
     9421 cgggattatt ggccaaagcc cgcgccagcc cgacacgctg ctgcatccca cccgacagtt
     9481 cacttaccat ctgattctcg tagcctttca gccccaccag ttgcatactt tccatcgctt
     9541 tctgctcccg ttctcccttt tttactccct gtagttcgag cccgaaagct atattatgca
     9601 agacagaacg gtgaggaagc agaccgaagt tctgaaagac catagccagt tctttccggc
     9661 gaatctgcaa cagttcctta tccgacactt tggctatgtc tgttccattg ataatcactt
     9721 ctccggaagt agggcgtatc aaacggttga tgcagcggag taaagtggac tttccactac
     9781 cggacagccc cataatgacg aatatttcgc cttcattaat ggaaagattc gcatctttca
     9841 ccgcaactgt acatccggtc gctttcaata tttcactttt tgttttacct tctttcaaca
     9901 tcttcaaagc cttctgcttc tcattgccaa aaaccagata gagatcttta atttctattt
     9961 tactcataca ataaaatggt ttaggttatt aaaataatat acacagcaag acaagaacaa
    10021 acgataacag gaatctttct ttatatcgta taaagttctg atttaaataa gggacaaata
    10081 acaatgaatc ccgaaataat taataaaatg attattgaca gactgagtaa ttaaaaaagg
    10141 aatagaattt gataagataa tcctttcaac gaatagcaaa aaatagcatt tttatgtata
    10201 aaaacagcct gttccagtat cttgctggca caaagataca aaaaacggat taaacataca
    10261 aattatattc aaaatccggg gcatacagag ggctttattt gtaatgatat ggaaagtttc
    10321 cgggtaatat tcccctatca ctcagcaaaa tagaacaaac cggcagataa atataaaata
    10381 agtttgaata tttcacttaa acaccgtata tttggcgtca ataactaaac tagatttata
    10441 tgttcaacag ggctattaca attttcctgg ggaaggataa ttgtcattac acaacaaaag
    10501 aaaaacaaac aggtactgcc acactagacg acaaaagcca agtacagttc cttagtaaaa
    10561 agaaccccaa aatgccgttt ttctatagcc ggcggaatct ctacatgata ggtttcctgc
    10621 tcgcttttat agtgactctg ctcgaattta tacgaggacg gcatcaaaac tttatggtct
    10681 tctcggacgc tactcaattc ttctggcaag gcatcagccc atacacaact gaatttgtag
    10741 aagctcacgg acgctacttc ctttattctc cagttttcac ggtattgttc gctccgtttg
    10801 cgtatctgcc tgcatggctg ggacctttcg cgtggaatct attcaattat tcgctgttct
    10861 ttatggcgat cttcacgctg ccccaacaat tcacccagca gcagaaatgc cgtatgttcc
    10921 tttttctgtt actgatttta ggacaaagtt tactttcatt tcagtataac ataacggtag
    10981 cctatttatt cttattcgcc tatacgttat tggaaaaaga ccgtggattt ctggctgttc
    11041 tgttaatcat gatttcggga tgtaccaaag tatatggaat tttcgaactg gcattgttgc
    11101 tgtgctatcc tcacgtatgg cgtaactttg gctatgccgt tacaatgggc attgtattgc
    11161 ttgcattacc gttaatcaaa atagctcctg cagatttgct cccctattat gaagaatggt
    11221 gccatagtct tgctgttcat cagtccgccg gagcttatga ttcatttttc tatgcccgcc
    11281 ccattgcagc atggacattg ccacacttcc gtgcacttca gataggaatg ctcggcttgc
    11341 tgactctgct ctttttgggg aatttccgca aatggtcgtc ttttgccttc cgtgcccagg
    11401 ctttgggcat tctcatgggc tgggtagtat tactgagtga ctccgccgag aagcatacct
    11461 atattatcgc attggcaggt ttcatgctct ggtattggag cagaccaaca cgtaccgcaa
    11521 cagacaagat tctattttgg tgctgttttg tgctgttatg tatcgttcct atcgacatat
    11581 tcgtccctat acccatcaga gatttcatta ccaggacctt atggcttcat gtatgggttt
    11641 tctttattgt atggatacgg atgatatggc ttaccttcct tgcatccttc attcatccac
    11701 gtgccacaaa tgttctttca gattaacgca tccgttagct ttgaaagaaa cttcttctgc
    11761 cagcaagagt tgtttttgtt ccacccaacc gggcaccagc cttccggtgg aatttacaac
    11821 tctatggcag ggaatggata attcatccgg cacttctttc aatgcacgtc ccaccatccg
    11881 cgagcattgg ggtgccccca acagcaaagc aatacctcca taagtagata cttttcccac
    11941 aggtatctgg gatacgactt cgtacacttc cttccgaaag gattcggaaa agctctcttt
    12001 atctacttta taatctttca tatatccctc tttacgatat caatgaaatc atcctttcct
    12061 tttcaggaaa tctgtcgggc tctctccaaa ctgctcttta tagcacttgg cgaaataaga
    12121 aggtgaactg aaaccgactt cataaccaat ctccgctacg gtcatgtccg aagaagcaag
    12181 caaagaagct gccttcttca aacgggcgat acggagcaat tcattcggag agtagttagt
    12241 caatgattta atcttgcgat aaagctgcac acggcttagt cccatgtctt tgcccaagtc
    12301 ctccacattc aaaccggagt ctcccatttt ctcttcaatc aatgacttga atctttctac
    12361 aaaatccttg tccatatcgc agacatcttc ttttgccaat gtctgcccgt caccaaagaa
    12421 ctgtttcaga cgacggtgag aatcgatcag attgcggaca cgtgccagca acagctgtga
    12481 actgaacggc tttgaaatat aagaatccgc accaccgtca tatccctgaa tacgctgttc
    12541 gtccagtgaa cacgctgtca gcagaataac cggaatatga caggtctgta actcactttt
    12601 cagccggcgg caacattcaa tgccatcaat gcccggcatc atcacatcag aaatgatcag
    12661 gtccggaaca tacttcatag ccttacggat tccttcggag ccgtctgccg cttcaatcac
    12721 cgtatagtct gtatgcaaca acgtatggac atacgaacgg atatcctcat tatcatcaat
    12781 aatcagtacg gacggtttgg aagagtcata tcctttttcc agttcttcct cttccgccaa
    12841 tagaacatct gttgtacggg aatccgcaga aacaagggtg gtatccggtt cggcagcaac
    12901 agcctcacaa gactgtacag gcagttcaac ggtaaagacc gtgccctgtt tctcatcgct
    12961 ctctacggag atcataccac cgtgcatttc tacgaaggct tttaccaatg ccagtccgat
    13021 tcccgaaccg gtatggtgca tatcgatctt atagaaacgg tcgaatacat tgcgaatatg
    13081 ttcggcagaa atcatagaac cggtatttgc caccgtgaaa cgtatccatc gcttgtcctc
    13141 tttactaagg gaagacagac ggacggctat tttcccgttt tccggtgtaa acttaaaggc
    13201 attggacaga agattgaaat aaatacgttc cagcttctcc atgtctgcca gtgtatgata
    13261 atccgtatcc ggcatactat caaaagaaaa atggatatgc ttcttacggg ctgccgcctg
    13321 aaaagactca ttccatcctt cgaaagaaga aaggacatcc accgtaaccg gagtatattc
    13381 catcttgccg ttttcatatt tacggaaatc cagaatctga ttgaccagac gcagaagaat
    13441 gttcacattc cgctgaatca gcatgagcat ccggtgctga tctccgctca gtgtcttgtc
    13501 cgccaacaaa tgttctaccg ggtcggcaac caatgtcaac ggagtacgga agtcgtgaga
    13561 aatattggtg aaaaagacca gcttggcatg ggtagcttct tccagttgat gagagagctg
    13621 tatcaattgg tcacgctgtt cttccagttt gtcacgctgc tcttccaatt gctgcttctg
    13681 cttaaaaagc tctttattca agcgattctt agagcggagt gatttataaa cgaccaataa
    13741 taagccggct accaataaaa ggataatcag actgccgtat aaaacgacct gttgtgtagc
    13801 tacctgagag agatagccac cgatacgtcc gttgagcgtt tcaatctttt tgtcgagttc
    13861 ggaaatgtgt gtggtctgca actgcatgac gtgtgcgttg gtacggtcca caacagcggt
    13921 attcatcacc gtttctttgg gatagggttt cttctccaga atgtccatag ccagttgcag
    13981 taccttatcg ccattggtcg gatagataaa ggtggcatcc agcacactgt ccagtaccag
    14041 ttccagtccg tttcccttac ccggcaaggc atctatgccg acaaaaatca tttccttctc
    14101 ccgccctgcc atctttgctg cctgataggc acccggagcg atacggtcat tatgggcata
    14161 cacagcatca atcttaggat gcctccgaag catactatcc atttctatct ctgccggacc
    14221 acgttcccac gcagcatccg ctttatcaat cagctttata tccgggaatt tactgatggc
    14281 agccataaat ccctgatgcc gttccattgc aggagtcgaa ccgctcaatc ctgtcagttc
    14341 tactatattt cccttccctt tcagactgga ggcaatatag tttcctaccg aacgaccgat
    14401 ttcataatta tcggctccga tataggcagt atatttatcc gaaagaatct tccggtctac
    14461 aagaataacg gggatgcctt tctgataagc ttcttctaca atcggagtca taggagcagc
    14521 ttcgttagcg gaaataatca gcagatcgac tccttcgtcc ataaaataat ggacatcttc
    14581 cgcctgctta ctgttatcat cccctgccga acggatttcc accgaaacac cattataaaa
    14641 catcgcttcc cgaagaatct catcattcat cttatgtcgc catgaatcat cgctgcattg
    14701 agccacccca atacgaaaac ggggtgtatc ctgccggcaa gccgtcatcc cgattaaacc
    14761 aaacagcacc agcatccact tcagatatct catcgtcttc atccatctca tcatttcata
    14821 gttctttctg taatccaatt aagaacaaaa ataagaaata atactgtaaa gttctctaac
    14881 ttcagctatt tattattcta aaaagaagga aagcagtcct ctttcagacc atcggaaagt
    14941 attaacaaaa gtataaagcg taaaacaaac acttaatcaa tgttataaaa catagcgttt
    15001 tacttggata atttgcagat ttcacagaag tccgtatctt tgcactgtgt ttttcatagt
    15061 attagattta aggttaacaa aggttggagc aaggcgttgc tccttttttt atgctctgac
    15121 ctttcatcta ccggttagtt ttcatcccat tccttttcca gtttaccatc aatagtgtag
    15181 cgtttccatc gtcctacacg gtgaccattc ttatattccc cacattcacg aagctggtca
    15241 ttctttacat aacgagcttc gaacggtccg ttctgccttc cgttcacata ggtagaagtt
    15301 tcccaataat caaagcggtt gctcactatc agccgtcgtt ccttgccatg caatctgccg
    15361 gcctgatagg tagcttcata tctcaattca ccattttcca aattatattc acggtataaa
    15421 ccgtctttac gatcgttctt catataatat tctttctgcc ttaccccact tccgttggca
    15481 aatgagacat ggagtccatc ttcttttcca tccagatagg tttcaatcat cagcgtatct
    15541 ccgctttcag caaaagtagt ccaacgacca ttcttctttc cattcttata actacccagt
    15601 atacgtggcg agccaaacgt aaacacggac gaatattcac cgtcctgaaa accttcttca
    15661 ttgaaataaa cggtctcata caaatcatat gtacctttca gaaaagtata ctgtttgcct
    15721 acctgcttcc cgtccttgta attatgctct ttccgcaaag taccgtcaga ttcgtacgac
    15781 agttgcttcc cgtgctcttt ccccatccgg aagtttcttt cactttccac ttttccggta
    15841 gtaaagtaac ttttgctcgt accgtccagc ttaccttcct tataggactt ttcttctttc
    15901 agcttaccgt caaacttgga gttaatcttg aagaggccat ccttccgccc ttctttataa
    15961 cttccttccg ttattaatat attgtccaca tattctttgt atccgccatc ataaaaacca
    16021 tctttaaaag atgccagcac ataggcggaa tgataaccat ctatgatgcg atgttcgcca
    16081 ttcaatgctt tttccgtttt cagttcctga aacaacagtc tgccatcgcc tacattaaca
    16141 acagatacct gatcgatctt atattccttt tgcgcaaaca aaggaagagc aagatataaa
    16201 aacaaaaata cgttccagct ttttgatctg aggaagttcg aaatgtgttt cataaagtag
    16261 ttttctcttt ttgatttatt atttaaaaac ctgccgcaaa gataggcaat cggcttataa
    16321 aacaaggcaa gaaagagggg gacaattaga aaaaagaaca tctgttatta tcattctaat
    16381 aattaacaga ttaagtagta aatcaaaaca cagggaaggg ggacatttac tgaaataaga
    16441 aacagaaaag aagatgtgtc aaaagcaact aaattcccct ccttcaggaa ggaggagagt
    16501 ttagttgctt ttgacacatt tacatttgca gtattaaata tc
//
