LOCUS       gnlProkkaGDCDGBIC_66   10631 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GDCDGBIC_66.
ACCESSION   gnlProkkaGDCDGBIC_66
VERSION     gnlProkkaGDCDGBIC_66
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 13:18:55
            Original ID  :: gnl|Prokka|GDCDGBIC_66
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10631
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10631
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1317:5631]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1318..5631
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..10631
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10631
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             3..95
                     /locus_tag="ctg66_1"
                     /transl_table=11
                     /translation="MGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             106..1254
                     /locus_tag="ctg66_2"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             1318..2037
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 54.5; E-value:
                     1.6e-16)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg66_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 4.3e-16, bitscore:
                     50.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             2058..3359
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg66_4"
                     /sec_met_domain="CTP_transf_like (E-value: 5.2e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 5.4e-121, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 6.1e-63, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             3376..4500
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg66_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 2.8e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.5e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             4510..5631
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg66_6_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg66_6"
                     /sec_met_domain="Aminotran_5 (E-value: 4.1e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        4600..5607
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg66_6_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg66_6_Aminotran_5.1"
                     /locus_tag="ctg66_6"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             5628..5771
                     /locus_tag="ctg66_7"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             6010..7458
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg66_8"
                     /sec_met_domain="Polysacc_synt (E-value: 4.1e-31, bitscore:
                     99.6, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWSAIERFSLQGVQFIIQIILARLLLPSDYGMIGMLAIFLQVAQV
                     FIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIADFYNMPTLVLVI
                     RFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWMAYVGCGVWALVW
                     QTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLINTVYRNLYTIVIG
                     KKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCLTNAYRNYIRLSS
                     YIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQINLNLLWVKGRS
                     DLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYYTNSLIDLTLKLQ
                     VKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLSFLFKLDSFFCIL
                     TLIIKTKNIDENIKKDFSSNSKDN"
     CDS             7412..8671
                     /locus_tag="ctg66_9"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             8680..9429
                     /locus_tag="ctg66_10"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKNSK"
     CDS             9429..10469
                     /locus_tag="ctg66_11"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 agaaagggaa catagctaat attttaggtt atgctacttc cttcagttct ttgggaatga
       61 tgattgcttc tattgctaat ttgataaaga aataaatgac ctattatgat tgaaaagcaa
      121 tcttatcaag aaccgttttc tgaagtggat aaaaggaaag atgatgaaat ggaaatagac
      181 ttgatggcta ttttttataa gattattact gttcgtggag tactatgcaa agctgctgga
      241 gtgggagtaa taattgctat agtggtggca ttgagcattc ccaagcaata tacagtaaag
      301 gttacccttt ctcctgaaat gggtaatgcg aagggaagta atggtttagc cggacttgct
      361 gcctcgtttt tgggagatgg ggctctaata ggggaaagca cagatgcctt gaacgcttct
      421 ctttcagcag atattgtttc ttcaactcct tttttattgg aacttttaga aatggaagtc
      481 tccgtttcta aaaaggatga taaaatgact ttggggtctt atctcgatga agagtcatct
      541 ccttggtggg attatcttat aggttttccg ggcatagtaa taggaggagt taaatcatta
      601 ttcggagaag atacggttcc tgccagtgga gggcggcaag gaactatcga attgacgaaa
      661 gaagtaaatg agaagattaa ttttcttaaa aagaagatta gtgcatccat tgataagaaa
      721 accgccataa cgagcattac ggtcacctta caaaatccgc agatcactgc ggttatagca
      781 gattctgtcg ttcataaatt acaggaatat attattgggt atcgaacttc aaaagtaaaa
      841 gaagactgtg cgtatttgga acggttgttt aaagaacgtc agcaggaata ttatgctgct
      901 caaagaaaat atgcggatta tgtagacgcc catgataatg tggttcttca aagtgtacgt
      961 gctgagcagg agcgtttaca gaacgacatg agtttggctt atcagatata tagtcaggtt
     1021 gctaatcagt tgcaggtatc cagagccaaa gtacaggagg aaaagccagt ctttgcagta
     1081 gttgagcctg ccgttgtacc tttgaaacct tcaggtatgg gactcaaaat ttatatttta
     1141 ttatttgtgt tcctgtccgt atctggtact ctcgtgtggg tgttttttgg caaaagtctg
     1201 ctggctagct tgagaaaaga actgaaaaat aaggagatag aacaggataa atgatgctaa
     1261 aacgtcgttt acaacattct tacatcaatt aaattcactt actatattat taaacgaatg
     1321 atacgtacag ctatgataat ggctgcgggc atgggaaccc gttttggcca atatacagaa
     1381 ttgataccta aagggttcgt caaagtggga ggtattccaa tgatagttcg ttctattgat
     1441 actttgttat catgtgacat tgagcgaatt gtaatcggta caggatataa acaagaagtt
     1501 tatgaagaat tgaagacaga ctatcctatg cttgaaacct gttttagtcc tcgttatgct
     1561 gaaacaaata gtatgtatac tttatataat acgcgggaga ttctgggcaa tgatgatttt
     1621 ttattgttag agtcagattt gatttttgag aaacaagcaa taatgagctt attggagtgt
     1681 cctgcggcag atgcaatgct aataactcca gtgacaaagt ttcaagatca gtattatgtg
     1741 gaacatgatg ataattttcg cctttcttca tgttctgtca ataagaataa actaaacgct
     1801 aaaggcgaat tggtcggcat ccataaacta tccggttcct tttacaaaat aatgtgtgct
     1861 gattatgcga gtattgttga tgaacaaccc aatttgggat atgagtatga attactacga
     1921 atatcttgtt ctcaatctcc tgtttatgtg cataaagtag aagggctgaa atggtatgaa
     1981 atcgatgaca tatcagattt ggaatatgca gagaaatata ttgttccgta ttgttaatta
     2041 aaataatata tcaaattatg agtaagacag tttatattgg gatgactgcg gatattatgc
     2101 atccaggact tatccgcatt attaatgagg ctactaaata cggtgatgtt ataattggtc
     2161 ttcttacaga taaagctatt gcggagcata aacgccttcc ttatctgacc tatgaacaac
     2221 gaaaagaggt agttcagaat attaaaggcg tatgtaaagt tgttcctcaa gaagaatgga
     2281 gctatgttga gaatctcaaa cgcattaaac ctgactatat aattcatggt gacgactgga
     2341 aaaccgggcc tttacgtgaa gaacgtgtgc gcgtatttga agtgatgaat gaacagggag
     2401 gaaaggttat cgaaattcca tatactttgg gaattaattc atcttctttg gataaagata
     2461 ttaaggctat aggtacaacc cctgatgtac gtttaaaatc acttcgtcgt ttgataaatg
     2521 ccaaacccgt agttcgtatt ttggaagctc atgatggact atgtggcttg ataattgaaa
     2581 atcaggaaat attaaaaggg gataagaggg aagtatttga cggaatgtgg tctagtagcc
     2641 ttacggattc aaccagtaaa ggtaaacctg atattgaggc ggttgattta actacccgat
     2701 tgcaagattt gaataatatt ctggagtgta ctactaaacc tattattttt gatggagata
     2761 caggtggtaa aattgaacat ttcgtattta cagtacgcac tttagaacgt catggaattt
     2821 cagctataat aattgaagat aaagttggat taaaaaagaa ttcattgttt ggtacagatg
     2881 ttattcaaac tcaagataca atcgaaggtt tctgtaataa gatcaaagca ggaaaggcat
     2941 ctcagattac tgatgatttt atgattatcg ctcgtattga gagccttata gcgggaaagc
     3001 cggtaagtga tgctttagag agagcttttg catatgtcca agcgggagcg gacggtatta
     3061 tgatacatag caaaaataag tcgggtgaag atataaaaga attttgtttg gcgtttcgaa
     3121 aacagtatgc tcatgtacct atcgtggttg tgcctactac atatgatcat atttatgagt
     3181 ctgaattgtg tgattggggt gtgaatataa ttatttatgc taatcatatg cttcgtgccg
     3241 cttatcctgc tatgatgaat gtcgcaaaga taatattaga gaatgaacgt gctttagagg
     3301 tgcgcgaact gtgtatgccc ataaaagaaa tattggaact gattccaggt actaaataaa
     3361 aagaggaata tcattatgtt aagcgtagaa aaagtttatg aaacgtttct gagtcatgac
     3421 gttgattttt ttacaggagt tccagactca ttactaaaaa atatttgtgc ctatatcaca
     3481 gaccatactt cacgtgagaa acatatcata gctgctaatg aaggtgcggc tgtaggaatt
     3541 gcttcaggtt attatatggc atcaggtaag gttcctgtgg tttatatgca aaattccggc
     3601 ttgggtaata ctgttaatcc tctgctgtct cttgcagatg aacaagtata cagttttcca
     3661 atgcttttga tgattggctg gcgtggtgaa ccgggaacaa aagatgaacc tcagcataaa
     3721 aaacagggtg aggtaacttt agatttgttg aaagcaatgc ggattcctta tataattctt
     3781 gattcaaatg agaatgatgc atttattcag ctccatgata tcatacaatc agcaaaaact
     3841 aagaatattc ctcatgcaat aattattcgg aaagatgttt ttggcaaata taaacttcaa
     3901 aaagagttcg gatgtaatta tcctttatct cgtgaggatg ctttgcaaat agttgtggat
     3961 tatctgcctg aaaattcagt ggtcgtttct actactggca agctttctcg tgagttattt
     4021 gaatatcgag aaatgaaaga gcaaggtcat gaacatgatt ttctcacggt aggctctatg
     4081 ggacatagtt catcaatctc tttgggtatt gctatagcaa agcaagatag acctgtttat
     4141 tgcttggatg gtgatggagc atttattatg catttagggg caattagtaa cattggcgat
     4201 ttatctccta aaaactatta tcatattttg tttaacaatg gtgctcacga gtctgtagga
     4261 ggacagccta ctttaggatt tagtttagat attccggcta ttgtccgggg gagcggatat
     4321 aagcatactt atactgtttg tacaaaagtt gaaattgaag aagcaatgaa gcagcttcca
     4381 aagttatgtg gtcctgtttt gttggaaata aaggttaaaa tagattctcg ggagaatttg
     4441 ggacgtccca cgactactcc tatagagaat aaggagcatt ttatggattt tttaaaataa
     4501 atatattcga tgaaaataga aagaaaaata ttattaaatc ctgggcctgc cactactact
     4561 gacagtgtaa aaatggcaca agttgttccg gatatttgtc ctcgcgagaa agaattcgca
     4621 ggtatgatga aacaacttcg ggacgatttg gtcagagttg ctcatgggaa tttggaaaaa
     4681 cataccgctg tattattttg tggctcagga accatcaata ttgatatatg tctaaattct
     4741 cttcttcctg aagacaaaag ggtgcttata gtgaataatg gggcatatag tacccgtgct
     4801 gtagaagtgt gtcaatatta tggtttgcct catattaatt tggaattttc cgtttacgaa
     4861 cgtcctgatt tatcggtggt ggaaaatgtg ttgcaagaaa atcctgatat agctatggtt
     4921 tatactactc atcacgagac gggtacagga attctgaacc ctattcgcga gatgggcgct
     4981 atagctcata aatatcaggc taaatttgtc gtcgatacta cttcttcttt gggcatgatt
     5041 ccttttgata tagagaaaga taatgtggat ttttgtatgg catctgctca aaaaggactt
     5101 caagcgatga caggtctttc ttttattata ggcaatgagg aacagattaa gttttcaaaa
     5161 aaatatccca agcgttctta ctattgtaat ctttatttgc agtatgagaa ttttgagaga
     5221 acaggtgaaa tgcattttac tccaccggta caaactattt acgccactcg tcaggcatta
     5281 aatgaatatt ttgaagtggg tgaagaagct aagtttgccc gtcacaaaag agtttttgag
     5341 gctattcatt caggtataaa tgaaattggt cttaaaagtg taataaagcg tgaatggcag
     5401 tcaggactgg ttgtctcagt tcaataccca gaagatccca actgggattt tgagaaaata
     5461 catgattatt gttatgagcg tggatttacg atttatccag gtaagatatc aactgaggat
     5521 acttttagaa tctgtgcttt aggagagata gaagtagatg atattgagaa cttctttaaa
     5581 gtactaaaag ctgcattaaa tcattataac gtcacattac cgatgtcatg attgcagaaa
     5641 tattattgaa gattcgtcat ttttattttt cccttcgtgg tatacacttc catccggaaa
     5701 gtgttatttc tggagtgcct attcgtagct ttcgcttagt aggcaaatat ggcaatatta
     5761 atttgaggtg atgcattagg agttctttat tcttataaaa aggcatcggt agttatagga
     5821 gataatgttt gtgtagggta atttgctttt agtgggagag accatattag aattgcggta
     5881 aggggcgaag aagataataa ccaattagtg agaatattgg aaaaatataa ttgatatcgg
     5941 taaatgtagt tgtttttata ctgtatttaa gtaatggaaa atctaaagca gaaaactgta
     6001 tcaggaataa tgtggagcgc tatagaacgt ttctctttac aaggagtaca gtttataatt
     6061 caaataatat tagctcgttt gttactacca tcggattatg gtatgatcgg gatgttagct
     6121 atttttcttc aagtcgctca agtatttata gatagcggtt ttacaaatgc tttaatccag
     6181 aaaaaagata gaactgaaga ggattttgcc actgtctttt attttaatat tcttgtcgca
     6241 gtattattct atggtatatt gtttttttcg gcttctttga ttgcagactt ttataatatg
     6301 ccgactttag ttcttgtaat tcgttttata gcattgtcgt tgataataaa tgctttatcg
     6361 gctattcaca gaacgaaatt aattatttct gtaaacttta aaactcaatc taaaatttca
     6421 ttaggtgcag cttttatatc aggcgtgatt ggaatatgga tggcttatgt cggttgcggg
     6481 gtttgggctt tagtttggca aactctctta aatagtataa ttttgacaat tttgttttac
     6541 tgtttagttc attggaaacc tttacatact ttctccaaaa gttcttttga aagattattc
     6601 aatttcggat ctaaattatt gatctcaagt cttatcaata cagtatatcg taatctgtat
     6661 accattgtaa taggaaaaaa gttttctgtt gtagagcttg gttactatac aagagcagaa
     6721 caatttgcta tttttccttc caataattta aatgctttag tttctagagt agcgtatcct
     6781 attttaagtt ccattcaaga tgatgataaa tgtttaacaa acgcatatcg aaattatatc
     6841 agattatcct catatataat ttttccttta atggtaggtt tacttgtttt ggctaatcct
     6901 attattagtc tattgttaac agataaatgg tctggggttg ttattctttt acagatatta
     6961 tgtttggatt ggatgtttga tcatttgagc caaattaatt tgaatttatt atgggttaaa
     7021 ggaagatctg atctgtcgtt acgtcttgaa ataataaaaa agacgattgc tatattcatt
     7081 ctttttgtgt caattccatt tgggcttgag gtgatgtgtt ggggtagagt tatttactct
     7141 ctgatagcga catatttgaa tacatattat actaattctc ttattgattt gaccttaaag
     7201 ttgcaagtta aagatgtatt tccaagttta atactctctt tcataatggg ggggatcgtt
     7261 tttatatgta tttctttctt tgaaactgat atagtaaaaa ttgtgattgg atgtattact
     7321 gggatgtcct tctatatttt actttctttt ctttttaagc tagattcttt tttttgtatt
     7381 ttaacattga tcattaaaac taaaaacata gatgaaaata ttaaaaaaga tttttcaagt
     7441 aatagtaaag ataattaacc attgtgtgcc agttgatagt agatcattgt attttattcc
     7501 tcatcctaat tgtagaacag ataaatatga tattataaat tattcgtcag ataatgttct
     7561 cgttctgtta aattatttgc taaaaaaaga tagtgctgaa tattataaaa tatatgttga
     7621 aatttatgat tcttctcgta tttcagaata tcaagaatat atttatggca taaatcctaa
     7681 tattaggtgt acttttttat gtgcatgtgt tggacgtttt ttctttaata aagtatcttt
     7741 taaggatatg ttgtatgcct ttttttgttt ttgtagagca agtaaatgtt ttacagctac
     7801 tttttattat gatttttcat ttaaaaaacg ctctcaacag attatttgtt tggggtatta
     7861 tactccattc aaagatgatt atcatatggg agatcattct tatgataaat ttcgtaatac
     7921 aacatgtaac tcatttgatt actctattgc tacttcttgt ttaagtgcta gaataatttc
     7981 aatagattgt ggaatctcat atgataaatt caaagtctta ggatttccca gaaatgattt
     8041 gttgatatcg aaaaataatt gcaatgttat taaaagagaa atttcgaaat ttgcgggata
     8101 tgatgtaact aaatatatag tttatactcc aacttttcgt gattatgaga ctgttactga
     8161 aggtaatttg cgttcaatac tcggatatgt tgattgtgat ttgttgaagt tatcgaaaat
     8221 actattgaag tttaatgcgg ctttaattct taaattacat cctttgcaga ataaaacagt
     8281 cttaaaaaaa gatttaccca aaggtatact tgtttttgaa caaacatata aatatggatt
     8341 gtatgatctt ttgtcatttt cagatggaat gattactgat tatacttcta cctattttga
     8401 ttttttattg gtaaataagc cagtcatatt taatttctac gatattgaag aatatcgtag
     8461 agtaagaggt ttctcatttg agccaataga atttttttgt gcaggtgata ttgtttacaa
     8521 ttataatgaa ttgatagatg ctgtgatggg acttctggct gggaaagata ttcatgctga
     8581 acatcgacgt catatttctt tattgatgaa tcaatttcaa gatgataatt caacaaagag
     8641 aatatgtgac atatttttaa atgaaatata ataaataaaa tgaattatgc atttgtggtg
     8701 caggcacgtt taggttctac acgtttgcct ggaaaaatat tgaaaccttt ctatggtaat
     8761 caatcgattc ttgacttaat ggttcataag ctttctgcta tatcgaatat tccagtaatt
     8821 attgctacaa caaattctgt tatcaatgaa cctattgaaa agaaggcact tgcattaggg
     8881 gtaaagtgct tcagaggtga ggagaatgat gttttaaaac gattcattga tgttgctgaa
     8941 tattttgata tacagggtat attccgaata tgttctgata atccattttt agatgtacat
     9001 gcggcaaggc aattggtcga aatagcaatg aaatcttgta acgattatat aagttttgat
     9061 attgatggta ctccatcaat taaaactcat ttcggttttt ggggagaatt tgtaacgctt
     9121 gatgcgctga agcgagttat aggatttact gatgatttat tgtatcgtga acatgttact
     9181 aattatatat atagtcatcc tgaacttttt aatattcaat ggatttcagg atctccagtc
     9241 gtgtcaaaac atcataatat tcgactcacg attgatacgt tagaagattt ttctgtagca
     9301 cagagaatat atagggattt acaagaaaaa agagtggaaa tatcgataga agtgattgta
     9361 gactatgttc gaagacatgc agaatacatt caactgatga aacaacaaat aaaaaaaaat
     9421 tctaaataat gaagaatact tatattattg gtgaaatagg gcagaatcat aatggttctg
     9481 ttgacttggc taagttgatt attgaattaa tctcacgacc tgtacatgag gatgtttttg
     9541 gtatggattt catgccaatg aatgctgtta aaatgactaa aagagattta tcagaagaat
     9601 tggctgtttc tcaaatgaat caaatatatg acaatcctaa ttcttttggg cgtacttatg
     9661 gtgaacatcg tgcttttctt gagcttgatg atcaagcgca ttttgagatt tataaatatg
     9721 ctaagtcatt aggattagat tttatcgaga cgttatgtgc caaaggatgt ctgtctttgc
     9781 ttaaactgtt cacaccggat aggctaaaag ttgctagtcg tgatttgact aacttaccat
     9841 tgcttgaagc attagcagaa actcatattc ctattatatt atcgacagga atggctggtc
     9901 aaagagaact tgacaatgca ttagatgtga taacgagata tcatagtaat atagctattc
     9961 tacattgtgt atctcagtat ccaactcatc caaataattt gaatctacgt acaataacat
    10021 atttgaagaa gcattacaat aagtttgaga taggtttttc tgatcataca ataggtattt
    10081 ctgctgctac agctgctgta gcgatgggag cggaaattat agaaaagcat gtaacaattg
    10141 atcggcatat gaaaggaaca gaccagcttg gctctttagg tccagatggg gttaatcgta
    10201 tgattcgaga tattcgcata gcagagtgtt ggcttggtac tgaagatctt tatatagaaa
    10261 aaggggtgga gaagtctaag ataaaacttg aacgttctat tgccactcga aaatatattc
    10321 cagcaggtag tattattcaa gagtcggaca ttcatttact gagtcctggt gatggttata
    10381 aatggataga taaaaaaaat gtaattggtc attttgctaa acaagatata tcagcgaatg
    10441 aaataatata tcctgatttt attgaataga tatattccta ctgcaacttg tattacggta
    10501 tagagtactg cctgctataa gctaagtagt gattaataaa taagggtaaa atactaaaaa
    10561 aatgaaagag ataaagctta tacttacaga tattgatggc gtttggactg atggcggaat
    10621 gttttatgat c
//
