LOCUS       gnlProkkaIMAEPNHC_33   12991 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IMAEPNHC_33.
ACCESSION   gnlProkkaIMAEPNHC_33
VERSION     gnlProkkaIMAEPNHC_33
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 14:16:47
            Original ID  :: gnl|Prokka|IMAEPNHC_33
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12991
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12991
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[3677:7991]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3678..7991
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..12991
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12991
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             44..2455
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 30.5;
                     E-value: 2.4e-09)"
                     /gene_kind="transport"
                     /locus_tag="ctg33_1"
                     /sec_met_domain="Poly_export (E-value: 1.6e-18, bitscore:
                     56.9, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIQRLFSILLFCLMLGSGSLMAQSMSDSQVLEYVKDGIRQGKEQ
                     KQLASELARKGVTKEQAMRVKQLYEQQNNVNTSKSTGTDINESRLREETKKNTSDMLED
                     HPTTQDLARGDQVFGRNIFNTRNLTFEPSVNLATPANYRLGPGDEVIIDIWGASQNTIR
                     QQISPEGTINIQKIGPVNLSGMTVSAANDYLKNALNKIYNGLNNTTDPTSDIRLTLGNI
                     RTIQINVMGEVVQPGTYALSSFSTVFHALYRAGGVSDIGSLRNVQLVRNGKNIATIDVY
                     EFIMKGNTQDDIRLQEGDVVIVPAYDVLVKISGKVKRPMRFEMKKDENLATLIKYAGGF
                     EADAYTRSLRVVRQNGEEYEVNTVKDMDYSIYTMRNGDVVTAEAILNRFTNKLEIRGAV
                     YRPGIYQLSGKLNTIRELVHEAQGLTGDAFLNRAVLYRQREDLTSEVVQIDIKSIMDGT
                     SPNLALMKNDILYIPSIHDLEDRGNVTVHGEVAHPDSYPYADNMTLEDLIIQAGGLKEA
                     ASTVRIDVSRRIKNPRSTADNDTIGQMYTFSLKDGFVIDGQPGFILQPYDEVYVRRSPG
                     YQAQQNVVIDGEILFGGNYAMTNREERLSDLVNKAGGPTNLAYLRGAKLTRVASAGEKK
                     RMGDVIRLMSRQLGEAMIDSLGIGVEDTFTVGIDLEKALTNPKGSADLVLREGDVVFIP
                     KNTNTVTINGAVMVPNTVSYMKGKNVDYYLNQAGGYSDNARKSKKFIVYMNGQVTKVKG
                     SGKKQIEPGCEIIVPGKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             2466..3614
                     /locus_tag="ctg33_2"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVNKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             3678..4397
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 54.5; E-value:
                     1.6e-16)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg33_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 2.4e-16, bitscore:
                     50.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             4418..5719
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg33_4"
                     /sec_met_domain="CTP_transf_like (E-value: 2.9e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 3e-121, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 3.4e-63, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             5736..6860
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg33_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.6e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.4e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             6870..7991
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg33_6_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg33_6"
                     /sec_met_domain="Aminotran_5 (E-value: 2.3e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        6960..7967
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg33_6_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg33_6_Aminotran_5.1"
                     /locus_tag="ctg33_6"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             7988..8131
                     /locus_tag="ctg33_7"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             8334..9818
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg33_8"
                     /sec_met_domain="Polysacc_synt (E-value: 2e-31, bitscore:
                     99.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLS
                     FLFKLDSFFCILTLIIKTKNIDENIKKDFSSNSKDN"
     CDS             9772..11031
                     /locus_tag="ctg33_9"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             11040..11789
                     /locus_tag="ctg33_10"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKNSK"
     CDS             11789..12829
                     /locus_tag="ctg33_11"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 tgcaggaact gtgtgaaatc aactgaaact tttttatttg tcaatgaaaa tacaacgact
       61 ttttagcatt ctactatttt gtttgatgct gggaagtggc tcgcttatgg ctcagtccat
      121 gagtgactca caggtactgg aatatgtaaa agacggcatc cgccaaggca aggaacagaa
      181 gcagcttgct tccgaactag cccgtaaggg tgtaaccaaa gaacaggcaa tgcgtgtgaa
      241 gcagctatac gagcagcaga acaatgtaaa tacctcgaaa tcaacgggca cggacatcaa
      301 cgaatcccgc ctgcgtgaag agactaagaa gaatacttcc gatatgctgg aggatcatcc
      361 gactactcag gaccttgccc gtggtgatca ggtcttcgga cgtaacatct tcaatacccg
      421 caacctgacg ttcgagccta gtgtcaacct tgccactcct gccaattacc gtcttggtcc
      481 cggtgatgaa gtcatcattg atatctgggg tgcgagccag aacacgatcc gccagcaaat
      541 ctctcctgaa ggtactatca acattcagaa gatcggccct gtcaacctta gcggtatgac
      601 agtctctgcc gccaatgact atctgaagaa cgccctgaat aaaatatata acggtctgaa
      661 taatactacc gatcctactt ccgacatccg tctgacgtta ggtaatatcc gtactattca
      721 gattaatgtg atgggagaag tcgtacagcc cggtacctac gccctttctt ccttctctac
      781 cgtcttccat gcgctttatc gtgcaggcgg tgtgagtgat atcggtagcc tccgaaacgt
      841 tcagttggta cgcaacggaa agaatatcgc caccatcgat gtttacgaat ttatcatgaa
      901 aggcaacacg caggatgaca tccgccttca ggaaggtgac gtggttatcg tccccgccta
      961 cgatgtcttg gtaaagatca gcggcaaggt aaaacgccct atgcgtttcg aaatgaagaa
     1021 agacgagaac cttgccactt taatcaaata tgccggcggc tttgaagctg atgcctacac
     1081 ccgttcatta cgtgttgtcc gtcagaatgg tgaggaatac gaagtcaaca cagtcaagga
     1141 tatggactac agtatctaca caatgcgtaa cggtgacgtt gtaacagccg aagccatcct
     1201 taaccgcttc acaaacaaac tggaaatccg tggcgctgtc tatcgtcccg gtatctacca
     1261 gctcagcggt aaactgaaca cgatccgcga acttgtccat gaagctcagg gtctgaccgg
     1321 tgacgctttc ctgaatcgtg ccgtcctcta tcgccagcgt gaagacctga ccagtgaagt
     1381 tgttcagata gacattaagt ctatcatgga cggcacttcc ccaaaccttg ccctaatgaa
     1441 gaatgacatc ctctacattc caagtatcca tgacctggaa gaccggggta atgtcacagt
     1501 tcacggtgag gttgcccacc ctgattccta tccttatgcg gataacatga cacttgagga
     1561 tctgatcatt caggccggtg gcttgaaaga agccgcctcc actgtccgca ttgatgtgtc
     1621 gagacgaatc aagaatcccc gtagtactgc ggataatgat acgatcggtc agatgtatac
     1681 cttctcttta aaggatggtt ttgtcatcga cggtcagccc ggttttattc ttcagcctta
     1741 tgacgaagtt tatgttcgtc gcagtccggg ttatcaggcg caacagaatg tagtcattga
     1801 tggtgaaata ttgtttggag gaaattatgc catgaccaac cgtgaggaac gtctttccga
     1861 tctggtgaat aaagcgggtg gtcctactaa ccttgcctat cttcgtggtg caaagctgac
     1921 ccgtgtggca agtgccggtg agaagaaacg tatgggtgat gtgattcgcc tgatgagcag
     1981 acaattggga gaggccatga ttgactcttt gggtattggt gttgaggata cctttacggt
     2041 aggcattgat ctggagaagg ctttgactaa tcctaagggt agtgccgacc ttgtcctacg
     2101 tgaaggtgat gtggtcttca tacctaagaa tactaatact gtaactatca atggtgctgt
     2161 catggttccg aatacggttt cttatatgaa gggcaagaat gtggattatt acctgaatca
     2221 ggccggtggt tattctgata atgcaaggaa gagtaagaaa ttcattgttt acatgaatgg
     2281 tcaggtgacg aaggttaagg gtagtggtaa gaaacagatt gagccgggat gtgagattat
     2341 tgtgcctggt aaggctaaga agaaagggaa catagctaat attttaggtt atgctacttc
     2401 cttcagttct ttgggaatga tgattgcttc tattgctaat ttgataaaga aataaatgac
     2461 ctattatgat tgaaaagcaa tcttatcaag aaccgttttc tgaagtgaat aaaaggaaag
     2521 atgatgaaat ggaaatagac ttgatggcta ttttttataa gattattact gttcgtggag
     2581 tactatgcaa agctgctgga gtgggagtaa taattgctat agtggtggca ttgagcattc
     2641 ccaagcaata tacagtaaag gttacccttt ctcctgaaat gggtaatgcg aagggaagta
     2701 atggtttagc cggacttgct gcctcgtttt tgggagatgg ggctctaata ggggaaagca
     2761 cagatgcctt gaacgcttct ctttcagcag atattgtttc ttcaactcct tttttattgg
     2821 aacttttaga aatggaagtc tccgtttcta aaaaggatga taaaatgact ttggggtctt
     2881 atctcgatga agagtcatct ccttggtggg attatcttat aggttttccg ggcatagtaa
     2941 taggaggagt taaatcatta ttcggagaag atacggttcc tgccagtgga gggcggcaag
     3001 gaactatcga attgacgaaa gaagtaaatg agaagattaa ttttcttaaa aagaagatta
     3061 gtgcatccat tgataagaaa accgccataa cgagcattac ggtcacctta caaaatccgc
     3121 agatcactgc ggttatagca gattctgtcg ttcataaatt acaggaatat attattgggt
     3181 atcgaacttc aaaagtaaaa gaagactgtg cgtatttgga acggttgttt aaagaacgtc
     3241 agcaggaata ttatgctgct caaagaaaat atgcggatta tgtagacgcc catgataatg
     3301 tggttcttca aagtgtacgt gctgagcagg agcgtttaca gaacgacatg agtttggctt
     3361 atcagatata tagtcaggtt gctaatcagt tgcaggtatc cagagccaaa gtacaggagg
     3421 aaaagccagt ctttgcagta gttgagcctg ccgttgtacc tttgaaacct tcaggtatgg
     3481 gactcaaaat ttatatttta ttatttgtgt tcctgtccgt atctggtact ctcgtgtggg
     3541 tgttttttgg caaaagtctg ctggctagct tgagaaaaga actgaaaaat aaggagatag
     3601 aacaggataa atgatgctaa aacgtcgttt acaacattct tacatcaatt aaattcactt
     3661 actatattat taaacgaatg atacgtacag ctatgataat ggctgcgggc atgggaaccc
     3721 gttttggcca atatacagaa ttgataccta aagggttcgt caaagtggga ggtattccaa
     3781 tgatagttcg ttctattgat actttgttat catgtgacat tgagcgaatt gtaatcggta
     3841 caggatataa acaagaagtt tatgaagaat tgaagacaga ctatcctatg cttgaaacct
     3901 gttttagtcc tcgttatgct gaaacaaata gtatgtatac tttatataat acgcgggaga
     3961 ttctgggcaa tgatgatttt ttattgttag agtcagattt gatttttgag aaacaagcaa
     4021 taatgagctt attggagtgt cctgcggcag atgcaatgct aataactcca gtgacaaagt
     4081 ttcaagatca gtattatgtg gaacatgatg ataattttcg cctttcttca tgttctgtca
     4141 ataagaataa actaaacgct aaaggcgaat tggtcggcat ccataaacta tccggttcct
     4201 tttacaaaat aatgtgtgct gattatgcga gtattgttga tgaacaaccc aatttgggat
     4261 atgagtatga attactacga atatcttgtt ctcaatctcc tgtttatgtg cataaagtag
     4321 aagggctgaa atggtatgaa atcgatgaca tatcagattt ggaatatgca gagaaatata
     4381 ttgttccgta ttgttaatta aaataatata tcaaattatg agtaagacag tttatattgg
     4441 gatgactgcg gatattatgc atccaggact tatccgcatt attaatgagg ctactaaata
     4501 cggtgatgtt ataattggtc ttcttacaga taaagctatt gcggagcata aacgccttcc
     4561 ttatctgacc tatgaacaac gaaaagaggt agttcagaat attaaaggcg tatgtaaagt
     4621 tgttcctcaa gaagaatgga gctatgttga gaatctcaaa cgcattaaac ctgactatat
     4681 aattcatggt gacgactgga aaaccgggcc tttacgtgaa gaacgtgtgc gcgtatttga
     4741 agtgatgaat gaacagggag gaaaggttat cgaaattcca tatactttgg gaattaattc
     4801 atcttctttg gataaagata ttaaggctat aggtacaacc cctgatgtac gtttaaaatc
     4861 acttcgtcgt ttgataaatg ccaaacccgt agttcgtatt ttggaagctc atgatggact
     4921 atgtggcttg ataattgaaa atcaggaaat attaaaaggg gataagaggg aagtatttga
     4981 cggaatgtgg tctagtagcc ttacggattc aaccagtaaa ggtaaacctg atattgaggc
     5041 ggttgattta actacccgat tgcaagattt gaataatatt ctggagtgta ctactaaacc
     5101 tattattttt gatggagata caggtggtaa aattgaacat ttcgtattta cagtacgcac
     5161 tttagaacgt catggaattt cagctataat aattgaagat aaagttggat taaaaaagaa
     5221 ttcattgttt ggtacagatg ttattcaaac tcaagataca atcgaaggtt tctgtaataa
     5281 gatcaaagca ggaaaggcat ctcagattac tgatgatttt atgattatcg ctcgtattga
     5341 gagccttata gcgggaaagc cggtaagtga tgctttagag agagcttttg catatgtcca
     5401 agcgggagcg gacggtatta tgatacatag caaaaataag tcgggtgaag atataaaaga
     5461 attttgtttg gcgtttcgaa aacagtatgc tcatgtacct atcgtggttg tgcctactac
     5521 atatgatcat atttatgagt ctgaattgtg tgattggggt gtgaatataa ttatttatgc
     5581 taatcatatg cttcgtgccg cttatcctgc tatgatgaat gtcgcaaaga taatattaga
     5641 gaatgaacgt gctttagagg tgcgcgaact gtgtatgccc ataaaagaaa tattggaact
     5701 gattccaggt actaaataaa aagaggaata tcattatgtt aagcgtagaa aaagtttatg
     5761 aaacgtttct gagtcatgac gttgattttt ttacaggagt tccagactca ttactaaaaa
     5821 atatttgtgc ctatatcaca gaccatactt cacgtgagaa acatatcata gctgctaatg
     5881 aaggtgcggc tgtaggaatt gcttcaggtt attatatggc atcaggtaag gttcctgtgg
     5941 tttatatgca aaattccggc ttgggtaata ctgttaatcc tctgctgtct cttgcagatg
     6001 aacaagtata cagttttcca atgcttttga tgattggctg gcgtggtgaa ccgggaacaa
     6061 aagatgaacc tcagcataaa aaacagggtg aggtaacttt agatttgttg aaagcaatgc
     6121 ggattcctta tataattctt gattcaaatg agaatgatgc atttattcag ctccatgata
     6181 tcatacaatc agcaaaaact aagaatattc ctcatgcaat aattattcgg aaagatgttt
     6241 ttggcaaata taaacttcaa aaagagttcg gatgtaatta tcctttatct cgtgaggatg
     6301 ctttgcaaat agttgtggat tatctgcctg aaaattcagt ggtcgtttct actactggca
     6361 agctttctcg tgagttattt gaatatcgag aaatgaaaga gcaaggtcat gaacatgatt
     6421 ttctcacggt aggctctatg ggacatagtt catcaatctc tttgggtatt gctatagcaa
     6481 agcaagatag acctgtttat tgcttggatg gtgatggagc atttattatg catttagggg
     6541 caattagtaa cattggcgat ttatctccta aaaactatta tcatattttg tttaacaatg
     6601 gtgctcacga gtctgtagga ggacagccta ctttaggatt tagtttagat attccggcta
     6661 ttgtccgggg gagcggatat aagcatactt atactgtttg tacaaaagtt gaaattgaag
     6721 aagcaatgaa gcagcttcca aagttatgtg gtcctgtttt gttggaaata aaggttaaaa
     6781 tagattctcg ggagaatttg ggacgtccca cgactactcc tatagagaat aaggagcatt
     6841 ttatggattt tttaaaataa atatattcga tgaaaataga aagaaaaata ttattaaatc
     6901 ctgggcctgc cactactact gacagtgtaa aaatggcaca agttgttccg gatatttgtc
     6961 ctcgcgagaa agaattcgca ggtatgatga aacaacttcg ggacgatttg gtcagagttg
     7021 ctcatgggaa tttggaaaaa cataccgctg tattattttg tggctcagga accatcaata
     7081 ttgatatatg tctaaattct cttcttcctg aagacaaaag ggtgcttata gtgaataatg
     7141 gggcatatag tacccgtgct gtagaagtgt gtcaatatta tggtttgcct catattaatt
     7201 tggaattttc cgtttacgaa cgtcctgatt tatcggtggt ggaaaatgtg ttgcaagaaa
     7261 atcctgatat agctatggtt tatactactc atcacgagac gggtacagga attctgaacc
     7321 ctattcgcga gatgggcgct atagctcata aatatcaggc taaatttgtc gtcgatacta
     7381 cttcttcttt gggcatgatt ccttttgata tagagaaaga taatgtggat ttttgtatgg
     7441 catctgctca aaaaggactt caagcgatga caggtctttc ttttattata ggcaatgagg
     7501 aacagattaa gttttcaaaa aaatatccca agcgttctta ctattgtaat ctttatttgc
     7561 agtatgagaa ttttgagaga acaggtgaaa tgcattttac tccaccggta caaactattt
     7621 acgccactcg tcaggcatta aatgaatatt ttgaagtggg tgaagaagct aagtttgccc
     7681 gtcacaaaag agtttttgag gctattcatt caggtataaa tgaaattggt cttaaaagtg
     7741 taataaagcg tgaatggcag tcaggactgg ttgtctcagt tcaataccca gaagatccca
     7801 actgggattt tgagaaaata catgattatt gttatgagcg tggatttacg atttatccag
     7861 gtaagatatc aactgaggat acttttagaa tctgtgcttt aggagagata gaagtagatg
     7921 atattgagaa cttctttaaa gtactaaaag ctgcattaaa tcattataac gtcacattac
     7981 cgatgtcatg attgcagaaa tattattgaa gattcgtcat ttttattttt cccttcgtgg
     8041 tatacacttc catccggaaa gtgttatttc tggagtgcct attcgtagct ttcgcttagt
     8101 aggcaaatat ggcaatatta atttgaggtg atgcattagg agttctttat tcttataaaa
     8161 aggcatcggt agttatagga gataatgttt gtgtagggta atttgctttt agtgggagag
     8221 accatattag aattgcggta aggggcgaag aagataataa ccaattagtg agaatattgg
     8281 aaaaatataa ttgatatcgg taaatgtagt tgtttttata ctgtatttaa gtaatggaaa
     8341 atctaaagca gaaaactgta tcaggaataa tgtggagcgc tatagaacgt ttctctttac
     8401 aaggagtaca gtttataatt caaataatat tagctcgttt gttactacca tcggattatg
     8461 gtatgatcgg gatgttagct atttttcttc aagtcgctca agtatttata gatagcggtt
     8521 ttacaaatgc tttaatccag aaaaaagata gaactgaaga ggattttgcc actgtctttt
     8581 attttaatat tcttgtcgca gtattattct atggtatatt gtttttttcg gcttctttga
     8641 ttgcagactt ttataatatg ccgactttag ttcttgtaat tcgttttata gcattgtcgt
     8701 tgataataaa tgctttatcg gctattcaca gaacgaaatt aattatttct gtaaacttta
     8761 aaactcaatc taaaatttca ttaggtgcag cttttatatc aggcgtgatt ggaatatgga
     8821 tggcttatgt cggttgcggg gtttgggctt tagtttggca aactctctta aatagtataa
     8881 ttttgacaat tttgttttac tgtttagttc attggaaacc tttacatact ttctccaaaa
     8941 gttcttttga aagattattc aatttcggat ctaaattatt gatctcaagt cttatcaata
     9001 cagtatatcg taatctgtat accattgtaa taggaaaaaa gttttctgtt gtagagcttg
     9061 gttactatac aagagcagaa caatttgcta tttttccttc caataattta aatgctttag
     9121 tttctagagt agcgtatcct attttaagtt ccattcaaga tgatgataaa tgtttaacaa
     9181 acgcatatcg aaattatatc agattatcct catatataat ttttccttta atggtaggtt
     9241 tacttgtttt ggctaatcct attattagtc tattgttaac agataaatgg tctggggttg
     9301 ttattctttt acagatatta tgtttggatt ggatgtttga tcatttgagc caaattaatt
     9361 tgaatttatt atgggttaaa ggaagatctg atctgtcgtt acgtcttgaa ataataaaaa
     9421 agacgattgc tatattcatt ctttttgtgt caattccatt tgggcttgag gtgatgtgtt
     9481 ggggtagagt tatttactct ctgatagcga catatttgaa tacatattat actaattctc
     9541 ttattgattt gaccttaaag ttgcaagtta aagatgtatt tccaagttta atactctctt
     9601 tcataatggg ggggatcgtt tttatatgta tttctttctt tgaaactgat atagtaaaaa
     9661 ttgtgattgg atgtattact gggatgtcct tctatatttt actttctttt ctttttaagc
     9721 tagattcttt tttttgtatt ttaacattga tcattaaaac taaaaacata gatgaaaata
     9781 ttaaaaaaga tttttcaagt aatagtaaag ataattaacc attgtgtgcc agttgatagt
     9841 agatcattgt attttattcc tcatcctaat tgtagaacag ataaatatga tattataaat
     9901 tattcgtcag ataatgttct cgttctgtta aattatttgc taaaaaaaga tagtgctgaa
     9961 tattataaaa tatatgttga aatttatgat tcttctcgta tttcagaata tcaagaatat
    10021 atttatggca taaatcctaa tattaggtgt acttttttat gtgcatgtgt tggacgtttt
    10081 ttctttaata aagtatcttt taaggatatg ttgtatgcct ttttttgttt ttgtagagca
    10141 agtaaatgtt ttacagctac tttttattat gatttttcat ttaaaaaacg ctctcaacag
    10201 attatttgtt tggggtatta tactccattc aaagatgatt atcatatggg agatcattct
    10261 tatgataaat ttcgtaatac aacatgtaac tcatttgatt actctattgc tacttcttgt
    10321 ttaagtgcta gaataatttc aatagattgt ggaatctcat atgataaatt caaagtctta
    10381 ggatttccca gaaatgattt gttgatatcg aaaaataatt gcaatgttat taaaagagaa
    10441 atttcgaaat ttgcgggata tgatgtaact aaatatatag tttatactcc aacttttcgt
    10501 gattatgaga ctgttactga aggtaatttg cgttcaatac tcggatatgt tgattgtgat
    10561 ttgttgaagt tatcgaaaat actattgaag tttaatgcgg ctttaattct taaattacat
    10621 cctttgcaga ataaaacagt cttaaaaaaa gatttaccca aaggtatact tgtttttgaa
    10681 caaacatata aatatggatt gtatgatctt ttgtcatttt cagatggaat gattactgat
    10741 tatacttcta cctattttga ttttttattg gtaaataagc cagtcatatt taatttctac
    10801 gatattgaag aatatcgtag agtaagaggt ttctcatttg agccaataga atttttttgt
    10861 gcaggtgata ttgtttacaa ttataatgaa ttgatagatg ctgtgatggg acttctggct
    10921 gggaaagata ttcatgctga acatcgacgt catatttctt tattgatgaa tcaatttcaa
    10981 gatgataatt caacaaagag aatatgtgac atatttttaa atgaaatata ataaataaaa
    11041 tgaattatgc atttgtggtg caggcacgtt taggttctac acgtttgcct ggaaaaatat
    11101 tgaaaccttt ctatggtaat caatcgattc ttgacttaat ggttcataag ctttctgcta
    11161 tatcgaatat tccagtaatt attgctacaa caaattctgt tatcaatgaa cctattgaaa
    11221 agaaggcact tgcattaggg gtaaagtgct tcagaggtga ggagaatgat gttttaaaac
    11281 gattcattga tgttgctgaa tattttgata tacagggtat attccgaata tgttctgata
    11341 atccattttt agatgtacat gcggcaaggc aattggtcga aatagcaatg aaatcttgta
    11401 acgattatat aagttttgat attgatggta ctccatcaat taaaactcat ttcggttttt
    11461 ggggagaatt tgtaacgctt gatgcgctga agcgagttat aggatttact gatgatttat
    11521 tgtatcgtga acatgttact aattatatat atagtcatcc tgaacttttt aatattcaat
    11581 ggatttcagg atctccagtc gtgtcaaaac atcataatat tcgactcacg attgatacgt
    11641 tagaagattt ttctgtagca cagagaatat atagggattt acaagaaaaa agagtggaaa
    11701 tatcgataga agtgattgta gactatgttc gaagacatgc agaatacatt caactgatga
    11761 aacaacaaat aaaaaaaaat tctaaataat gaagaatact tatattattg gtgaaatagg
    11821 gcagaatcat aatggttctg ttgacttggc taagttgatt attgaattaa tctcacgacc
    11881 tgtacatgag gatgtttttg gtatggattt catgccaatg aatgctgtta aaatgactaa
    11941 aagagattta tcagaagaat tggctgtttc tcaaatgaat caaatatatg acaatcctaa
    12001 ttcttttggg cgtacttatg gtgaacatcg tgcttttctt gagcttgatg atcaagcgca
    12061 ttttgagatt tataaatatg ctaagtcatt aggattagat tttatcgaga cgttatgtgc
    12121 caaaggatgt ctgtctttgc ttaaactgtt cacaccggat aggctaaaag ttgctagtcg
    12181 tgatttgact aacttaccat tgcttgaagc attagcagaa actcatattc ctattatatt
    12241 atcgacagga atggctggtc aaagagaact tgacaatgca ttagatgtga taacgagata
    12301 tcatagtaat atagctattc tacattgtgt atctcagtat ccaactcatc caaataattt
    12361 gaatctacgt acaataacat atttgaagaa gcattacaat aagtttgaga taggtttttc
    12421 tgatcataca ataggtattt ctgctgctac agctgctgta gcgatgggag cggaaattat
    12481 agaaaagcat gtaacaattg atcggcatat gaaaggaaca gaccagcttg gctctttagg
    12541 tccagatggg gttaatcgta tgattcgaga tattcgcata gcagagtgtt ggcttggtac
    12601 tgaagatctt tatatagaaa aaggggtgga gaagtctaag ataaaacttg aacgttctat
    12661 tgccactcga aaatatattc cagcaggtag tattattcaa gagtcggaca ttcatttact
    12721 gagtcctggt gatggttata aatggataga taaaaaaaat gtaattggtc attttgctaa
    12781 acaagatata tcagcgaatg aaataatata tcctgatttt attgaataga tatattccta
    12841 ctgcaacttg tattacggta tagagtactg cctgctataa gctaagtagt gattaataaa
    12901 taagggtaaa atactaaaaa aatgaaagag ataaagctta tacttacaga tattgatggc
    12961 gtttggactg atggcggaat gttttatgat c
//
