LOCUS       c00287_gnlPro..        10107 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GJDAMLMO_287.
ACCESSION   c00287_gnlPro..
VERSION     c00287_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 18:14:38
            Original ID  :: gnl|Prokka|GJDAMLMO_287
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10107
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10107
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[10:5816]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      11..5816
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..10107
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..10107
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             11..1813
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg287_1"
                     /sec_met_domain="ILVD_EDD (E-value: 2.6e-218, bitscore:
                     714.6, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKQLRSSFSTQGRRMAGARALWAANGMKKNQMGKPIIAIVNSFT
                     QFVPGHVHLHEIGQLVKAEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLID
                     AMIKSADDSVSDQEVANIEQNACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     ENRTKLFEDAAKLIVENAMKYYEEGDESVLPRSIATRQAFLNAMTLDIAMGGSTNTVLH
                     LLAVAHEAGVDFKMDDIDMLSRKTPCLCKVAPNTQKYHIQDVNRAGGIIAILAELAKGG
                     LIDTSVLRVDGMSLAEAIDQYSITSPNVTEKAMSKYSSAAGNRFNLVLGSQGAYYQELD
                     KDRANGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQEA
                     ACEGILGGRVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGG
                     TSGLSIGHVSPEAAAGGNIGKIVDGDIIEIDIPARTINVRLTDEELAARPMTPVTRDRY
                     VPKSLKAYASMVSSADKGAVRLID"
     CDS             1861..3558
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg287_2"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2e-47, bitscore:
                     149.7, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKDLITGAEAMMRSLEHQGVTTIFGYPGGSIMPTFDALYDHQNT
                     LNHILVRHEQGAAHAAQGYARVSGKVGVCLVTSGPGATNTITGIADAMIDSTPIVVIAG
                     QVGTGFLGTDAFQEVDLVGITQPIAKWSYQIRRAEDVAWAIARAFYIASSGRPGPVVLD
                     FAKNAQVEKTKYEPTQQEFIRSYVPVPDTDEESVKAAAELINNAERPLVLVGQGVELGS
                     AQEELRIFIEKADMPAGCTLLGLSALPTDHPLNKGMLGMHGNLGPNINTNKCDVLIAVG
                     MRFDDRVTGNLATYAKQAKVIHFDIDPAEVNKNVKVDIAVLGDCKKTLAAVTGLLKKNR
                     HTEWVDSFKEYEAVEEEKVIRPELHPATDSLSMGEVVRAVSEATRHEAILVTDVGQNQM
                     ISARYFKYTRERSIVTSGGLGTMGFGLPAAIGATFGRPDRTVCVFMGDGGLQMNIQELG
                     TIMEQKAPVKIICLNNNYLGNVRQWQAMFFNHRYSFTPMLNPDYMKIASAYDIPSKRVF
                     SREELKVAIDEMLSTDGPFLLEACVVEEGNVLPMTPPGGSVNQMLLEC"
     CDS             3577..4140
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg287_3"
                     /sec_met_domain="ALS_ss_C (E-value: 3.8e-20, bitscore:
                     60.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDKTLYTIIVHSENIAGLLNQVTAVFTRRQINIESLNVSASSIK
                     GVHKYTITAWTDKDTIEKVVKQIEKKIDVIQAHYFTEDEIYFHEIALYKVSTPAFQETP
                     EASKVIRRYNARIVEVNPVFSIVEKNGMSEEITSLYEELRALKCVLQFVRSGRVAITTS
                     CFERVNEFLDGQEAKYKQSKKEQE"
     CDS             4140..4883
                     /locus_tag="ctg287_4"
                     /transl_table=11
                     /translation="MSEENKIGTYQFVAEPFHVDFNGRLTMGVLGNHLLNCAGFHASDR
                     GFGIATLNEDNYTWVLSRLAIELDEMPYQYEKFSVQTWVENVYRLFTDRNFAVIDKDGK
                     KIGYARSVWAMINLNTRKPADLLALHGGSIVDYICDEPCPIEKPSRIKVTSNQPVATLT
                     AKYSDIDINGHVNSIRYIEHILDLFPIELYQTKRIRRFEMAYVAESYFGDELSFFCDEV
                     NENEFHVEVKKNGSEVVCRSKVIFE"
     CDS             4947..5816
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg287_5"
                     /sec_met_domain="IlvN (E-value: 1.4e-47, bitscore: 150.2,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 2.8e-29, bitscore: 91.2,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGTVENVVIRDEFPLEKAREVLKNETIAVIGYGVQGPGQ
                     ALNLRDNGFNVIVGQRQGKTYDKAVADGWVPGETLFGIEEACEKGTIIMCLLSDAAVMS
                     VWPTIKPYLTAGKALYFSHGFAITWSDRTGVVPPADIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAIYQDATGNAMDRTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMG
                     PFHDXXXX"
     CDS             complement(6522..8468)
                     /locus_tag="ctg287_6"
                     /transl_table=11
                     /translation="MKYIFVSGGRFTTFASIMNNHPKSPIIDLQQQQLLLRMEYEHEKE
                     EFKRQTETMGVARKVKRGLCWYPASPGRSYYNSLNQLVIDITRTENKEIEHSFEFGRPV
                     CFFRQSFDGKVNYMNFIATVSYADDERMVVVLPSAGALLELQTEEVLGVQLYFDETSYR
                     AMFEALEDTIRAKGNRLAELRDTLLGTQKPGFRELYPVRFPWLNSTQETAVNKVLCTRD
                     VAIVHGPPGTGKTTTLVEAIYETLHREPQVLVCAQSNTAVDWICEKLVDRGVPVLRIGN
                     PTRVNDKMLSFTYERRFENHSAYPELWGIRKSIREMGSRMRRGSYSEREGMRSRMSRLR
                     DRATELEILINADLFDSARVIASTLVSSNHRLLNGRRFPTLFIDEAAQALEAACWIAIR
                     KADRVILAGDHCQLPPTIKCIEAARGGLDHTLMEKVVQQKPSAVSLLKVQYRMHEAIMR
                     FPSEWFYNGELEAAPEVRNRGILDFDTPMNWIDTSEMDFHEEFVGESFGRINKQEANLL
                     LQELEAYISRIGKARILDESIDFGLISPYKAQVQYLRSKIRGSSFLRPFRSLITVNTVD
                     GFQGQERDVVFISLVRANEDGQIGFLNDLRRMNVAITRARMKLVILGDATTLTKHAFYR
                     KLIQYIRQEAVSS"
     CDS             8535..10106
                     /locus_tag="ctg287_7"
                     /transl_table=11
                     /translation="MVYDLTMLEAFYSAYKGKVEHVRAVLKRPLTLAEKILYAHLFNEG
                     DVKNYKRGEDYVNFRPDRVAMQDATAQMALLQFMNAGKEKVAVPSTVHCDHLIQAYKGA
                     KEDIATATKTNEEVYDFLRDVSSRYGIGFWKPGAGIIHQVVLENYAFPGGMMVGTDSHT
                     PNAGGLGMVAIGVGGADAVDVMTGMEWELKMPRIIGVRLTGKLSGWTSPKDVILKLAGI
                     LTVKGGTNSIIEYFGPGTASLSATGKATICNMGAEVGATTSLFPFDGRMATYLRATGRD
                     RIVELAEAVDCELRADQQVTDEPEKYYDRVIDIDLSTLEPYINGPFTPDAATPISEFAE
                     KVLLNGYPRKMEVGLIGSCTNSSYQDLSRAASLARQVKEKNLSVASPLIINPGSEQIRA
                     TAERDGMMDDFVQIGAVIMANACGPCIGQWKRHTDDSMRKNSIVTSFNRNFAKRADGNP
                     NTYAFVASPELTMALTIAGDLCFNPLKDRLMNHDGEKVKLAEPEGEELPLRGFTSGNEG
                     YIAPGGT"
ORIGIN
        1 atagattgaa atgaaaaagc aattacgcag ttcgtttagt acacaaggcc gtcgcatggc
       61 gggagcccgc gcattatggg cagccaacgg catgaagaaa aatcagatgg gaaaacccat
      121 tatcgctatc gtcaattcgt ttacacaatt tgttccggga cacgtgcacc tgcatgaaat
      181 cgggcagttg gtgaaggcgg aaattgagaa gctgggatgc ttcgctgcgg aatttaatac
      241 gattgctatt gatgacggta tcgctatggg acatgacgga atgctttact cgcttccttc
      301 ccgtgatatc atagcggaca gcgtagaata tatggtcaat gcgcacaagg cggatgcaat
      361 ggtatgtatc agcaactgcg ataagattac cccagggatg ctgatggctg ccatgcgcct
      421 gaatatccct accgtatttg tatccggcgg accgatggaa gccggagagt ggaacggtca
      481 gcatctggac ttgatcgatg ccatgattaa atcggcggac gacagtgtaa gcgatcagga
      541 agtagcgaat atcgaacaga atgcctgtcc tacctgcgga tgttgttccg gaatgtttac
      601 ggcaaactcg atgaactgtc tgaatgaagc tatcggcttg gctcttccgg gaaacggcac
      661 aatcgtggct acgcacgaaa atcgtacgaa actgtttgaa gatgctgcca aactgattgt
      721 ggaaaatgca atgaaatatt atgaagaagg agacgaaagt gtacttcccc gcagcatagc
      781 tacccgtcag gcattcctca atgccatgac gctggatatt gcgatgggcg gttctaccaa
      841 tacggtgctt cacctgttgg ccgtggcaca tgaggcagga gtcgatttca agatggacga
      901 catcgatatg ctgtcacgca agacaccctg cctgtgtaaa gtcgctccga atactcaaaa
      961 atatcatatt caggacgtta accgtgcggg tggcatcatt gctatcctgg cagagttggc
     1021 aaaaggcggt ctgattgata cttccgttct ccgtgtggat ggcatgtcgc tggcggaagc
     1081 gatcgatcaa tattcaatta ccagcccgaa cgttacggaa aaagcaatga gcaaatattc
     1141 aagtgcggca ggaaacagat tcaatctcgt acttggttct cagggagctt attatcagga
     1201 attagataaa gatcgcgcga acggatgtat ccgtgatctg gagcacgcct atagcaagga
     1261 cggaggcctg gcggtactga aaggaaatat cgctcaggac ggttgcgtag taaaaacggc
     1321 gggtgtagac gaaagcatct ggaagtttac cggacctgcc aaagtattcg actcacaaga
     1381 agcagcctgt gaaggcatcc tcggaggccg agtcgtcagc ggcgacgttg tcgtcatcac
     1441 gcacgaaggt ccgaagggcg gtcccggtat gcaggaaatg ctttacccga cttcttatat
     1501 caaatcccgt cacctcggca aagaatgtgc cttgattacc gacggacgtt tcagtggtgg
     1561 aacttccgga ttgagtatcg gacacgtttc tcccgaagcc gctgccggag gtaatatagg
     1621 aaaaatagta gatggagata tcatcgaaat cgacattccc gcccgaacga ttaacgtgcg
     1681 actaacagat gaagaactgg ctgcccgccc gatgactccc gtcacccgtg accgttacgt
     1741 gccgaagagc ctgaaagcat acgccagcat ggtaagctct gccgataagg gagcagtgag
     1801 attaatagac tgatccactt cattatccat tatgaatcat ccattatcca ttaaagaact
     1861 atgagtaagg acttaataac aggcgcagag gcaatgatgc gctctctgga acatcaggga
     1921 gtgactacca ttttcggtta tcccggcggt tccatcatgc ctacgttcga tgccctgtac
     1981 gaccatcaaa atacattgaa ccatatcttg gttcgccatg aacagggagc tgcccatgcg
     2041 gcacaaggct acgcccgtgt atcgggtaaa gtcggtgttt gcttggtgac aagcggcccc
     2101 ggagcaacca atacgatcac aggtattgca gatgcgatga tagacagtac gcctatcgtt
     2161 gtcattgcag gacaggtggg aacaggcttc cttggaacag acgcttttca ggaagtcgat
     2221 ctcgtaggta tcactcagcc aatcgctaaa tggagctatc agattcgccg tgccgaagac
     2281 gtagcctggg cgatagcacg tgctttctac attgccagta gtggtcgtcc tggtccggtg
     2341 gtactcgact ttgccaagaa tgcgcaggtt gaaaaaacaa aatacgagcc gacgcagcag
     2401 gagtttatcc gcagctatgt tccggttccc gatacagacg aagaatcggt aaaggctgcc
     2461 gccgaactga tcaataacgc cgaacgcccg cttgtcttgg taggacaggg agtggaactg
     2521 ggaagcgctc aggaagaact gcgtatcttt atcgaaaagg cggatatgcc cgcaggttgt
     2581 accttgctcg gactttccgc attgcctacc gaccatccgt tgaataaagg aatgctgggt
     2641 atgcacggaa atctgggacc gaatatcaat actaacaaat gtgatgtact gattgctgtc
     2701 ggtatgcgtt tcgacgaccg tgtgaccggt aatctggcta cttacgccaa acaagcgaaa
     2761 gtgatccatt ttgacattga tccggcggaa gtaaataaga atgtaaaggt agatattgcc
     2821 gttttgggcg actgcaaaaa gacgctggct gctgtgaccg gactgttgaa aaagaaccgg
     2881 cacaccgagt gggtcgatag tttcaaggaa tatgaagcgg tagaggaaga aaaagtcatt
     2941 cgtcctgaac ttcatcctgc aacggattca ctgagtatgg gcgaagtggt gcgtgcggta
     3001 agcgaagcga cccgtcacga agccatattg gtgacagatg taggtcagaa tcagatgatc
     3061 tctgcccgct actttaaata taccagggaa cgtagtatcg ttacttcggg tggactcggc
     3121 acgatgggtt ttggccttcc ggcagctatc ggagctactt tcggccgtcc cgaccgcact
     3181 gtatgtgtat ttatgggtga cggcggactg caaatgaaca ttcaggagct gggtacgatc
     3241 atggaacaga aagctccggt gaagattatc tgcctgaaca acaattatct cggcaacgtg
     3301 cgccaatggc aggctatgtt ctttaatcac cgttattcat ttactccgat gctgaatccg
     3361 gattacatga aaatcgcttc cgcctacgat attccttcca aacgtgtctt ttcacgggaa
     3421 gaattgaaag tggctatcga cgaaatgctc tcgacagacg ggccgttcct gctcgaagcc
     3481 tgtgtggtag aagaaggcaa tgtcctcccg atgacccctc cgggcggttc agtcaatcag
     3541 atgttgctgg aatgttaatc cttaatttag aaagttatga gtgataagac attatatacg
     3601 attatagttc attctgaaaa tatagccgga ttgctgaatc aggtgacggc tgtatttacc
     3661 cgtcggcaaa taaacatcga gagtttgaac gtttctgctt cttccattaa aggagtacat
     3721 aaatatacga tcacagcgtg gactgataag gacactattg aaaaggtggt gaagcagatc
     3781 gaaaagaaga ttgatgtgat tcaggcgcac tattttactg aagacgagat ttatttccat
     3841 gagatagcct tatataaggt atctactcct gcttttcagg agactccgga agcatctaaa
     3901 gtgatccgca gatataatgc ccgcattgta gaggtgaatc cggtattctc tatcgtcgag
     3961 aagaacggca tgagtgaaga gattacttcc ctttacgaag aacttcgggc tttgaaatgt
     4021 gtgctgcagt ttgtccgttc gggccgtgtg gctattacta ccagctgttt cgaacgtgtg
     4081 aatgagttcc tggacggaca ggaagcgaag tataagcaaa gtaaaaagga acaggagtaa
     4141 tgagtgaaga aaataaaata gggacttatc agtttgtggc agagccgttt cacgtagatt
     4201 ttaacggccg cctaaccatg ggcgtgctgg gaaatcatct gttgaattgc gcaggttttc
     4261 atgccagcga ccgtggattt ggtattgcta cgctgaacga ggacaattac acatgggtgc
     4321 tttcccgtct ggcgatcgag ctggacgaga tgccttacca atacgagaag ttctcggttc
     4381 agacatgggt ggagaatgtc tatcgtctct ttaccgaccg taactttgcc gtcattgaca
     4441 aggatggaaa gaagatcggc tatgcccgtt ccgtatgggc gatgatcaat ctgaatactc
     4501 gtaagcctgc cgatctgttg gcattgcatg gaggaagcat cgtcgattat atatgcgatg
     4561 aaccttgccc gatagaaaag ccttcgcgta tcaaggtgac aagcaatcag cctgttgcga
     4621 cgctgacggc aaaatacagt gatatcgata ttaacggaca cgtaaacagt attcgttata
     4681 tcgagcacat acttgacttg tttccgatag aactgtatca gacgaaacgt atccgccggt
     4741 ttgaaatggc gtatgtggct gaaagttatt tcggagatga actctctttc ttctgtgatg
     4801 aggtgaatga aaacgagttt catgtagagg tgaagaaaaa cggcagcgag gtagtatgcc
     4861 gttccaaagt gatatttgaa taatatagag tataaaatca attaataaca gatggcgcaa
     4921 gtcatcaaaa caaaaaaaca aaaaaaatgg cacagttgaa ttttggcgga actgtagaaa
     4981 atgtagttat ccgtgatgaa tttccattgg aaaaagctcg tgaagtattg aaaaatgaaa
     5041 caatcgctgt aatcggttat ggcgtacaag gtcccggaca ggctctgaac cttcgtgata
     5101 acggtttcaa tgtaatcgtt ggtcaacgcc agggaaagac atatgacaaa gcggttgctg
     5161 acggatgggt tccgggtgaa actttgttcg gtattgaaga agcttgcgaa aaaggtacga
     5221 tcattatgtg cctgttgtct gatgcagcag taatgtctgt atggcctact atcaagcctt
     5281 acctgactgc aggaaaagct ctttatttct ctcatggttt tgctattaca tggagtgacc
     5341 gcacaggtgt agttcctcct gcagatatcg acgtaatcat ggttgctcct aaaggttcgg
     5401 gtacatcctt gcgtactatg ttccttgaag gtcgcggctt gaactcttct tacgctatct
     5461 atcaggatgc aacaggcaac gctatggaca gaacaatcgc attgggtatc ggtatcggtt
     5521 caggttattt gttcgaaaca actttcatcc gcgaagctac ttccgacctg acaggcgaac
     5581 gtggttcatt gatgggagct atccagggtc tgttgctggc acaatacgaa gtgttacgtg
     5641 aaaacggtca cactccttcc gaagcattca acgaaactgt agaagagctg actcagtcat
     5701 tgatgccgtt gtttgcaaag aacggtatgg actggatgta tgctaactgc tctactactg
     5761 ctcaacgtgg tgccctcgac tggatggggc ccttccacga tnnnnnnnnn nggtagttga
     5821 aaagttgtat cacagtgtta agactggtaa cgaagcacag atttcaatcg actctaactc
     5881 caaaccggat tatcgtgaga aactggaaga agaactgaaa gcattgcgcg aaagcgaaat
     5941 gtggcagact gccgtgacag ttcgtaaact tcgtccggaa aataattaat cagacttata
     6001 ctatataagt ttttcaaaag gcgggaaaag cgtattttcc cgccttttct atgtagatac
     6061 cggtcttttg agtaatagaa aaaggatgaa agtagaaaaa aaaattaaaa gatactgata
     6121 atataggtga aaaagagcat ttatgattac ctttacggca acaaataaaa cagaataggc
     6181 aatgaagaaa ctttttactt acagaagatc gatacgtatg aagatgattt cttctttaat
     6241 aaatagtata tcagaatgtt acattaaaag atatttaagt tattctctac cgaatggtag
     6301 ctgtaatacc atttcaagtc ctttttatat ttcgtgttcc attagtgatt cgttgatatg
     6361 atgcagaatt ttattctgta gcaggaaaaa gtatgcgtta aattgaattt aagacagagc
     6421 ttttggaaca gaatttagtg ggaaaataac attgtttgtt ttgtttgtaa atgggagtcc
     6481 tctttcgtga gaaagggggc ttcttttttt atcccgatga ttcaggagga taccgcttcc
     6541 tgccggatat actgtatcag tttccggtag aacgcatgct tggtaagagt ggttgcatct
     6601 cccaaaatca caagtttcat ccgggcgcgg gtaatggcta cgttcattcg tcttaaatca
     6661 ttcagaaaac cgatctgtcc gtcctcgttc gcccggacga ggctgataaa gacgacatcc
     6721 cgttcctgtc cctgaaagcc gtctaccgtg ttgaccgtga tgaggctgcg gaaagggcgg
     6781 agaaaactgc ttcctctgat tttacttctc aggtattgca cttgcgcctt gtagggcgaa
     6841 atcagaccaa agtcgatgct ctcgtccagg atgcgtgctt tgccgatccg gctgatatag
     6901 gcttccagtt cttgcagtaa caagttggct tcctgcttgt tgatgcgccc gaagctctcg
     6961 cctacaaact cttcgtggaa gtccatttcc gaggtatcta tccagttcat gggagtgtcg
     7021 aagtcaagga taccccggtt gcgcacttcc ggtgcggctt ccagttctcc gttgtagaac
     7081 cattcggagg gaaagcgcat gattgcctcg tgcatccggt attgcacttt gagcagcgag
     7141 acggcagaag gtttttgctg cacgactttt tccattaaag tatggtccag tccgccacgg
     7201 gcggcttcga tacatttgat tgtaggaggg agctggcaat ggtcgccggc aagaatcaca
     7261 cggtcggcct ttcggatggc gatccaacag gcggcttcga gtgcctgggc ggcttcatcg
     7321 ataaataagg tggggaaacg ccgtccgttg agcaaacggt gattgctgct gaccagcgtg
     7381 gaagcaatca cacgggcact gtcgaaaaga tcggcgttga tcaggatttc cagttcggtg
     7441 gcacggtcgc ggaggcggct catccggctg cgcattcctt ccctttcgga gtaacttccc
     7501 cgacgcatcc ggctgcccat ttcacggatc gattttcgga ttccccaaag ttcggggtag
     7561 gccgaatgat tctcaaagcg gcgttcgtaa gtgaaagaaa gcattttgtc attaacacgt
     7621 gtagggttac caatgcggag gacaggcaca ccccggtcta ccagtttctc gcaaatccag
     7681 tccacagccg tattactttg ggcgcagacc agcacctgcg gttcgcggtg aagcgtttcg
     7741 taaatggctt ccacgagcgt ggtagtcttt ccggttcccg gagggccgtg aacgatggcg
     7801 acatcgcgtg tgcataacac tttgtttacg gctgtttcct gcgtgctgtt cagccacggg
     7861 aaacggacgg gatataattc gcggaatccc ggcttttgtg ttcccagcaa ggtgtcccgg
     7921 agttcggcaa ggcggttgcc cttagcgcgg attgtgtctt ccagcgcttc gaacatggca
     7981 cgataggacg tttcatcgaa ataaagttgt acacccagca cctcttccgt ttgcagttcc
     8041 agtaaggcgc ccgcactggg aagcacgacc accatccgtt cgtcgtccgc ataactcacc
     8101 gttgcaatga aattcatgta attcactttt ccgtcaaatg actgccggaa aaagcagacg
     8161 ggacgaccga attcgaagga atgctcgatt tctttatttt cggtgcgtgt aatatctatt
     8221 acaagttgat ttagagaatt atagtaactt cgaccgggag aggcgggata ccagcacaga
     8281 ccacgtttca ctttgcgggc gacacccatt gtttcagtct gccgcttgaa ttcctccttt
     8341 tcgtgttcat actccatgcg tagcaggagt tgctgttgct gaaggtcgat gattggactt
     8401 ttcggatgat tattcataat agatgcaaag gtagtaaatc ttcctcctga gacgaaaata
     8461 tatttcattt tgttaaacat tcctcgaacg ccgttcgtta tttttataga tagactaaaa
     8521 aaaataaaag caatatggtg tatgatttga ctatgttaga ggctttttat tctgcttata
     8581 aaggaaaagt ggaacacgtg cgggctgttt tgaaacgccc tttgacgtta gccgagaaga
     8641 ttctgtatgc ccacctgttc aatgagggcg atgtgaaaaa ctacaaacgg ggtgaagact
     8701 acgtaaattt ccgtcccgac cgcgtcgcta tgcaggacgc gactgcccag atggcattgc
     8761 ttcaattcat gaatgcagga aaagaaaaag tggctgttcc ctccaccgtg cactgtgacc
     8821 acttgataca agcgtacaaa ggagcaaagg aggacattgc tacggcaacc aaaacaaacg
     8881 aagaagttta cgactttttg cgcgatgtat cctctcgtta cggcatcggc ttctggaagc
     8941 cgggcgccgg aatcattcac caggtagtgc tcgaaaatta cgctttcccc ggtggaatga
     9001 tggtaggcac cgactctcac actccgaatg ccggaggatt gggcatggtg gccatcggtg
     9061 tcggcggtgc ggatgccgta gacgtgatga caggtatgga atgggaactg aaaatgccaa
     9121 ggattatcgg tgtccgcctg accggaaaat tgagcggctg gacttccccg aaagatgtca
     9181 tcctgaaact tgcagggatt ctgaccgtaa aaggaggaac gaactccatc atcgaatatt
     9241 tcggaccggg aacggcttcc ctgtcggcta ccggcaaagc gaccatttgc aatatgggtg
     9301 cggaagtagg agctaccact tcgcttttcc cgttcgacgg gcgcatggct acttatctga
     9361 gagccactgg cagagatcgt atcgtggaac tggcggaagc cgtggactgt gaactccgtg
     9421 cggaccaaca ggtgacggac gaaccggaaa agtactacga ccgtgtcatt gacattgact
     9481 tgtctacgct cgaaccttac atcaacggcc ctttcacacc ggatgccgct acccctatct
     9541 ctgaatttgc agaaaaagta ttactgaacg gctatccgcg taagatggaa gtcgggctga
     9601 tcggttcgtg taccaactct tcttaccaag atctcagccg tgccgcatcc cttgcaaggc
     9661 aggtgaagga aaagaatctg agtgtggctt ccccgctgat catcaatccg ggttccgaac
     9721 aaattcgcgc cactgccgaa agagacggaa tgatggatga cttcgtgcag atcggcgccg
     9781 tgatcatggc aaatgcctgc ggtccttgca tcggtcagtg gaaacgtcat acggacgact
     9841 cgatgcggaa gaactcgatc gtcacctcct tcaaccgcaa ctttgccaaa cgtgcggacg
     9901 gcaatccgaa cacatacgcc tttgttgctt ctcccgaact gacgatggca ctgaccattg
     9961 ccggtgatct ttgcttcaat ccgctgaaag acagactgat gaatcatgat ggcgaaaaag
    10021 tgaaactggc cgaaccggaa ggcgaagaac tccccttgag aggatttacc tccggtaatg
    10081 aaggctatat cgcccccggc gggacga
//
