LOCUS       c00027_gnlPro..        16301 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EHAKMBNL_27.
ACCESSION   c00027_gnlPro..
VERSION     c00027_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 17:38:53
            Original ID  :: gnl|Prokka|EHAKMBNL_27
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16301
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16301
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2749:6301](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2750..6301
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16301
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16301
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(177..1304)
                     /locus_tag="ctg27_1"
                     /transl_table=11
                     /translation="MAPASARQMASELALLPMWYAEEGSVVLAPSAYNLDYVKKIQELL
                     GLSVDLMTEPELASERNLDIRPWGWDIAIRKRLLDLGVEESELPSIEQLDKLRFCSHRS
                     CAVGLLPQLQLGACFCGESFYLTFPEEWKSFVESHDTCLLKAPLSGSGKGLNWCKGVYT
                     PSISGWCSRIGKQQGGVIGEPLYNKVEDFAMEFRSSSNGRFGFAGYSQFRTGGSGAYEG
                     NLLISDAAIERNLLEYIPVEEIYKLRDRLEQELSLRFGTIYNGYLGVDMMICRFPESPV
                     YRIHPCVEINLRMNMGVVARHIYDHYIYPTSTGAFQISYYPTEGTAWRAHKEMEEAYPL
                     EIEQGRIKSGYLSLVPAHKKSSYRAWVFISKSVFL"
     CDS             1539..2717
                     /locus_tag="ctg27_2"
                     /transl_table=11
                     /translation="MESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGIKGTRGVGKT
                     TFLLQYAKEKFGNDRSCLFINMNNFYFSGHSIVDFANEFQKRGGKVLLIDQVFKHPEWS
                     KELRMCYDRFPNLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREYLNLQTGMKFR
                     AYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENLLKTMNMMVE
                     VDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDIQTSRATVMNYIKYLADAR
                     LINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFVNSLWKDHKVHKGD
                     KNVSFMVDEVMPFKICQEGAKIKNNPNVTYALHKAEIGRGNQIPLWMFGFLY"
     CDS             2750..6301
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg27_3"
                     /sec_met_domain="PFOR_II (E-value: 1.4e-18, bitscore: 57.9,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 1.6e-82, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 1.6e-31, bitscore: 100.4,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.3e-12, bitscore:
                     37.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 5.5e-12, bitscore: 37.3,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 8.9e-09, bitscore: 26.0,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 4.4e-05, bitscore: 14.8,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 2.7e-25, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMNPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKTIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQILSVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIALEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLAVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNPENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKVFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKTKQHLVDIKSNVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTTNENGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARIVKLFNEILAADNASPEAKEVLKAWIENMYDADKTKE
                     LAPQVKAVIEEGLSHGCPICKELKGLTQYLVKRSQWIIGGDGASYDIGYGGLDHVIASG
                     KDVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQI
                     AMGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLW
                     RYNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPTEAEELFKAAEENAK
                     WRYNSYKRLARENWGAE"
     CDS             complement(6454..7320)
                     /locus_tag="ctg27_4"
                     /transl_table=11
                     /translation="MRIYKIVGIVLSAMLLLASCTNSDLEKKKVKIAYANWLEGIAMSH
                     LAKVVLEEHGYEVELQNADLAPIFVSMSGKKSDVFLDAWLPITMKDYMDQYGDSIEFFG
                     EVYGEARVGLVVPQYVTIHSINELEANKDRFSSEIVGIDAGAGIMKTTDKAIAAYGLDG
                     YTLMTSSSSTMLASLKKAMDKGEWIVITGWTPHWMFDQFDLKFLDDPKKVYGDLEEIHA
                     IAWKGFSEKDPFAAEFFGNIKLTTEELSSFMTAMKDARMDEEEIARKWRDEHRLLVDSW
                     IPKSENK"
     CDS             complement(7341..8165)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 92.9; E-value: 6.9e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg27_5"
                     /sec_met_domain="BPD_transp_1 (E-value: 2.8e-29, bitscore:
                     92.9, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIEMAINWMMIHFSTFFDAVNAGIGSFIIGFQHILFGIP
                     FYITILVLAALAWMKAGRGTAIFTALGLLLIYGMGFWEATMQTLALVFSSTCLALIVGV
                     PLGVWTANSSRAEKILRPVLDLMQTMPAFVYLIPAVLFFGLGAVPGVFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATRWQLLYKVQLPLALPTILTGVNQTIMMSLSMVVIA
                     AMIAAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIILDRITQGMAGRKNKN"
     CDS             complement(8162..9388)
                     /locus_tag="ctg27_6"
                     /transl_table=11
                     /translation="MSKIEIKDLYLIFGNEKQKALKMLKKDKSKEEILKDTGCTVGVKD
                     ANLSINEGEFFVIMGLSGSGKSTLLRCINRLIRPTTGQVLVNGVDISKISEKELLQVRR
                     KELAMVFQNFGLLPHRSVLSNIAFGLELQGVKKEEREKKAMESMKLVGLKGYENQMVGE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLALQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEVVQVGTSEEILTEPANDYVARFVENVDRSKIITASSLMID
                     KPLVARLKKEGPEVLIRKMRAKNITVLPVIDADDKLVGEVRLNDLLKLRSKQEKSIETI
                     VRTEVHSVLEDTVLEDILPLMTKSNSPVWVIDETREFLGTIPLSSLIIEVTGKDKEEIN
                     EIIQNAIDL"
     CDS             complement(9687..10025)
                     /locus_tag="ctg27_7"
                     /transl_table=11
                     /translation="MKDYKVDKASLSASFCQEVYQVVREIPVGKVSTYGGIAALLGMSQ
                     CSRMVGRALKQIPDDLSAPCHRVVNASGRLVPGWTEQKQLLLEEGISFKQNGCVDLKKH
                     LWNYSVPE"
     CDS             10109..11404
                     /locus_tag="ctg27_8"
                     /transl_table=11
                     /translation="MQLYLLYLQIIPTFVPIKSNPIINKTSTAVMKKKTILFASCLLGA
                     LAFSSCEKNLYDESKQPEKEKKMTDLEVPADFDWKGSQNAKVKIASQSTATISVFLEEN
                     CNEEALMLRMDVDANTSKLELPIEIPAYIKNVYVKYGNGSEIQTVPVESNGTISIVVPA
                     NATALSRVTTRANKEVETNNIFNYPGYGNGTIMFEDMYPALGDYDFNDFVAWYNFQIDG
                     FYWSHNQCYAEYLMIGFQIRAIGGIYDYNPYIRLAEVQYNELDLEETQMYLERNNPEEA
                     ENIKILKGPKGELIISLKKPAIPNGYKYYNTEVNEKTKPKKMMAIYLVFNSPVNVKSLQ
                     DSKMDFYIAKTNKGQEIHLKGYSPVYYNSNESYVNEDNFIWGLKVPASLHHAREEVNFL
                     EAYPDFEQWVTSGGQENQRWWNKPKTNKLIMN"
     CDS             complement(11546..14428)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 62; E-value: 2.1e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg27_9"
                     /sec_met_domain="Peripla_BP_1 (E-value: 8.4e-20, bitscore:
                     62.0, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEAMKYMKWITVLFCLLGLAACRQDAPRFRIGVAQCSDDSWRHK
                     MNDEILREAMFYDGVSVEIRSAADDNRKQAEDVHYFIDKGVDLLIISANEAAPMTPIVE
                     EAYQKGIPVILVDRKILSDKYTAYIGADNYEIGRAVGNYIASSLKGKGNVVELTGLGGS
                     TPAMERHQGFMAAISNYPDIKLIDKADAAWEREPAEVEMDSMLHRHPKIDAVYAHNDRI
                     APGAYQAAKKAGREKEMIFVGIDALPGKGNGLELVLDNVLDATFIYPTNGDKVMQLAMN
                     ILEKKSYPRETVMNTAVVDRTNAHVMQLQTTHISELDQKIETLNGRIGGYLSRVATQQV
                     VMYGGLVILLLVAGLLLVVYKSLRSKNRLNKELSEQKKQVEQQRDKLEEQRDILEEQRD
                     KLEEQRDQLIQLSHQLEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADSSLSEDQR
                     RMLLLVQRNVNILLRLVNQILDFRKYENGKMEYTPISLDILSSFEGWNESFMAAARKKH
                     IHFSFDYMPDTDYRTLADVEKLERIYFNLLSNAFKFTPENGKVTVRLSSLTKDDHCWIR
                     FTVANTGSMISAEHIRNIFDRFYKIDMHHAGSGIGLALVKAFVELHKGTITVESDEKQG
                     TIFTVDLPVQTCETVVSENSPAFSVPATSVTSTDAATSAVAGAPVTPATSGYSGSSSLN
                     DALTYEEEELEKSYDSSKPCVLIIDDNADIRLYVHGLLHTDYTVIEAAYGSEGIRKAMK
                     YVPDLIISDVMMPGMDGIECCRRLKSELQTCHIPVILLTACSLDEQRIQGYDGGADSYI
                     SKPFSSQLLLARVRNLIDSHRRLKQFFGDGQTLAKEDVCDMDKDFVEKFKALIEAKMGD
                     SNLNVEDLGKDMGLSRVQLYRKIKSLTNYSPNELLRIARLKKAASLLASSDMTVAEIGY
                     EVGFSSPSYFTKCYREQFGESPTDLLKRKG"
ORIGIN
        1 gtaaactaac ttaggtataa caagcgaagt tgtcaactaa atccagtaca gtacacacat
       61 ggcatgtgat tacttgtttc atgcaatgaa actttttgtt tctcggtgtg gaaccaatgg
      121 tttcactaca tgaaactatc agtttcacac cgagaaacca taacttcgat ataatatcac
      181 aaaaacacgc tttttgagat aaacacccac gcccgataac tactcttttt atgagccggc
      241 accaatgaca aatagcctga ttttattctt ccttgttcta tttccaaagg ataagcctcc
      301 tccatttctt tgtgtgctct ccaggctgtt ccttccgtag ggtaatagct tatttgaaaa
      361 gctcctgttg aagtaggata gatataatgg tcataaatat gacgcgctac tactcccata
      421 ttcatcctca agttgatttc cacgcaagga tgaatccgat aaacaggaga ttctggaaag
      481 cgacagatca tcatatccac tcccaaataa ccattataaa tggttccgaa acggagggat
      541 aattcttgtt caaggcggtc gcgcaattta taaatttctt cgacagggat atattccaaa
      601 agattccgtt cgatggctgc atctgaaatc agcagattac cttcgtacgc cccacttcca
      661 cccgtacgga attgagagta tccggcaaag ccaaatcgac cattactcga agaacgaaat
      721 tccatagcaa aatcttccac cttattatat agaggttcgc caataacacc tccttgctgt
      781 ttgccaatgc gtgagcacca accggaaata gaaggagtat atacaccttt gcaccagttc
      841 agccctttcc cgctaccgga taaaggagct ttcagtaaac aagtatcatg tgattctaca
      901 aatgacttcc attcttcggg aaacgtcagg taaaaagact ctccacaaaa acaggctccc
      961 agttgtagct gtggtaataa tcccacagcg caggaacgat gggaacagaa acgcagttta
     1021 tccaattgct caatagaagg aagctcgctt tcttccactc ccaaatccaa cagtcgtttt
     1081 cttattgcta tatcccagcc ccaaggacga atatccaaat tccgctccga agcaagttca
     1141 ggttctgtca tcaaatcaac cgaaagtcct aataattcct gtatcttctt cacatagtcg
     1201 agattataag cggaaggagc caatacaaca cttccctctt ctgcatacca catcggcaac
     1261 aaagccaatt cggatgccat ctgccgggcg gaagccggtg ccatatagtt tgtttcaccg
     1321 ctggctaacg ccaaatcatg ttccggattg aatatataaa gagccttttt tgtcatttta
     1381 aacgaattca aaactttatt ctgcaaatat atacaggaaa tagtcaggaa tggctacaat
     1441 aaacagaaag ttctaattaa actcacaatt ttgccatctc tactttgcaa atcctaaaaa
     1501 aagcagtata tttgccaccc gaaaaacaaa gaactgaaat ggaatcattc tatcgcacac
     1561 acgcctacct cgttgagcac accaatgccc ccgttcgccg cgatcttatg gacgagatcg
     1621 actggagcga ccgcctgatt ggtatcaaag ggacacgtgg cgtaggaaaa accactttcc
     1681 ttctccaata cgccaaagaa aaatttggga acgaccgctc ctgcctgttc atcaacatga
     1741 acaacttcta cttctctggc cacagcattg tagactttgc taacgaattt cagaaacgtg
     1801 gcggaaaagt attgttgatc gaccaggtgt tcaaacatcc ggaatggagc aaagagttac
     1861 gcatgtgtta cgaccgtttt cctaacctga aaattgtctt caccggctcg tccgtgatgc
     1921 gactgaaaga agaaaatctt gaattacgtg atatcgccaa gagctataac ctgcgcggat
     1981 tttcttttcg cgaatacctg aacttacaga caggcatgaa attcagggca tacagcctcg
     2041 aagaaattct tagcactcac gaacagattg ccaaaggagt actctctaaa gttcgtccgc
     2101 tggattactt ccaggattac ctgcatcatg ggttctatcc gttcttcctc gagaagcgta
     2161 acttctcgga gaatttgctg aaaacgatga acatgatggt ggaagtagat atacttctca
     2221 tcaaacaaat tgaactgaaa tatctttcaa agataaaaaa attactatat ttgctcgctg
     2281 tcgacgggcc gaaagctcca aatgtgagcc aactggcaag cgacatacag acatctcgcg
     2341 ccacggtgat gaactatatc aagtatctgg cagatgcgcg actcattaat ctggtttatc
     2401 cgaaagggga agaattccct aaaaaacctt cgaagataat gatgcacaac tccaacctga
     2461 tgtattccat ctacccggtg aaagtggagg agcaggatgt gctcgacact ttctttgtga
     2521 attctttatg gaaagaccat aaggtacata aaggagataa aaacgtctct tttatggtgg
     2581 acgaagtaat gccgttcaaa atttgccagg aaggagcaaa gatcaagaac aatccgaatg
     2641 tgacgtacgc gttgcataag gctgaaatag gtcggggcaa ccagatacct ctctggatgt
     2701 tcggcttttt atattaaaag atttatttac ttaaatattt aatttagtta tgactaaaca
     2761 gaagaaattc atcacttgtg atggtaacca ggctgcagcg catatctcgt atatgttctc
     2821 tgaagtagct gctatctacc ccatcactcc ttcttcgact atggctgagt acgtagacga
     2881 atgggctgcc gcaggacgta agaacatctt cggcgaaaca gtattggtac aggaaatgca
     2941 atctgaaggt ggtgctgccg gtgcagttca cggttctctt caggctggtg cgttgactac
     3001 tacttacact gcttctcagg gtcttctcct gatgatccct aacatgtaca aaattgccgg
     3061 tgagttcttg ccttgcgtat tccatgtatc tgctcgtaca ttggcttctc acgcattgtg
     3121 tatcttcggt gaccaccaag acgtaatgtc agctcgtcag actggctttg cgatgttggc
     3181 tgaaggctct gtacaggaag ttatggattt ggctggtgtt gctcacttgg ctactatcaa
     3241 atctcgtgtt ccgttcatga acttcttcga tggtttccgt acatctcacg aaatccagaa
     3301 gattgaaatg ttggaaaatg atgatcttgc tccgctgatt gatcaggaag ctttggctga
     3361 attccgtgcc cgcgcactga atccgatgaa tccggttgct cgtggtatgg ctgaaaatcc
     3421 tgaccatttc ttccaacatc gtgaatcatg caacaactac tatgaagcag ttcctgctat
     3481 cgtagaagaa tacatgaatg aaatttctaa gattacaggt cgtaaatacg gtttgttcga
     3541 ttattatggt gcagaagatg cagaacgcgt aattatcgct atgggttctg taacagaagc
     3601 tgcccgcgaa gctatcgacc acttggtagc aaatggcgaa aaagtgggta tggttgccgt
     3661 acacctgtat cgtccgttct ctgctaaaca cttcctggct gctgtaccta agactgccaa
     3721 gactatcgca gttcttgacc gtactaaaga accgggcgct aacggcgaac ctctttacct
     3781 tgacgttaaa gactgcttct acggcgcaga aaatgctccg gttatcgttg gcggtcgcta
     3841 cggtttgggt tcaaaagata ctactcctgc tcaaattctt tcagtattcg agaacttggc
     3901 catgccaatg ccgaagaatc acttcactat cggtatcgta gacgacgtta ctttcacttc
     3961 tcttcctcaa aaagaagaaa tcgctttagg cggtgaagga atgttcgaag ctaaattcta
     4021 cggtttgggt gctgacggta cagtaggtgc taacaagaac tctgtaaaga ttatcggtga
     4081 caacactgac aaacactgcc aggcttactt ctcttatgac tctaagaagt caggtggttt
     4141 cacttgttct cacttgcgtt tcggtgatac tccgatccgt tccacttatt tggtaaatac
     4201 tccgaacttc gttgcttgtc acgttcaggc ttacctgcac atgtacgatg taactcgtgg
     4261 tttgcgtaag aacggttctt tcttgctgaa cactatctgg gaaggtgaag aactggctaa
     4321 gaacctgcct aacaaggtta agaaatattt tgcacagaac aacatttccg tatactatat
     4381 caacgcaaca cagattgcat tggaaattgg tttgggtaat cgtaccaaca ctatccttca
     4441 atctgcattc ttccgtatca caggtgttat tcctgtagac caggctgttg aacagatgaa
     4501 gaaattcatc gttaagtctt acggtaagaa gggtgaagac gttgttaaca agaactatgc
     4561 tgccgttgac cgtggtggtg aatacaagac tttagctgtt gatcctgctt gggctaacct
     4621 gccggatgat gcaaaagctg aaaacaacga tcctgcattc atcaacgaag tagttcgtcc
     4681 gatcaatgca caagatggtg acttgctgcc tgtatctgca ttcaagggta tcgaagacgg
     4741 tacttggtat caaggtactt ctaaatacga aaaacgtggt gtagccgcat tcgttcctga
     4801 atggaatcca gaaaactgta tccagtgtaa caagtgtgca tacgtttgtc ctcacgcttc
     4861 tatccgtccg ttcgtactcg atgctgaaga gcagaagggt gctaagttcg aacaattgaa
     4921 agcagtaggt aaagtattcg acggtatgac attccgtatc caggttgacg ttctcgactg
     4981 tctgggttgc ggtaactgtg ctgacatctg tccgggtaat ccgaagaagg gtggcaaagc
     5041 attgacaatg aaacacctcg aaagccaatt ggctgaagct gacaactgga cttactgtgc
     5101 tgaaaacgtg aagactaaac aacatcttgt tgatatcaag tctaacgtga agaactcaca
     5161 gttcgctact ccgttgtttg agttctctgg tgcttgctct ggttgtggtg aaactccgta
     5221 tgtgaaattg atttctcaat tgttcggtga ccgtgaaatg gttgctaacg ctaccggatg
     5281 ttcttctatc tactctggtt cagttccttc tactccgtat actacgaacg aaaacggtca
     5341 cggtcctgct tgggctaact cactgttcga agacttctgt gaattcggtt tgggtatgga
     5401 attggctaac gaaaagatgc gtgctcgtat cgtgaagtta ttcaacgaaa tccttgctgc
     5461 cgacaacgct tcacctgaag caaaagaagt gctgaaagca tggattgaaa acatgtacga
     5521 tgctgacaag actaaagaat tggctcccca agtgaaagca gtgattgaag aaggtctttc
     5581 tcacggatgt cctatttgca aagaactgaa aggactgact caatatcttg taaaacgcag
     5641 ccaatggatc attggtggtg acggtgcttc ttacgatatc ggttatggtg gtcttgacca
     5701 tgtaatcgct tccggtaagg acgttaacat cctcgttctg gatactgaag tttactctaa
     5761 cacaggtggt cagtcttcta aggctactcc ggtaggtgct atcgctaagt tcgctgctgc
     5821 tggtaagcgc gtacgtaaga aagacctcgg tctgatggct actacttacg gttatgtata
     5881 tgttgcacag atcgctatgg gtgctgacca agctcaaact ctgaaagcta tccgtgaagc
     5941 tgaagcatat ccgggaccat ctttgattat cgcttacgct ccatgtatca accacggtct
     6001 gaaagcaggt atgggtaaga gccaggaaga agaagaaaaa gctgttaagt gcggttactg
     6061 gcacttgtgg cgttacaacc cagctttgga agaagaaggc aagaacccat tccaattgga
     6121 tagcaaagaa ccgaactggg aagatttcca aggtttcttg aagggtgaag ttcgttacgc
     6181 ttctgtaatg aaacaatatc ctactgaagc tgaagaactg tttaaagctg ctgaagaaaa
     6241 cgctaaatgg cgttacaaca gctacaaacg tttggctaga gaaaactggg gtgctgaata
     6301 atagtaatac cctataaata taaagcggta atcttatcaa agattaccgc ttttttattg
     6361 tatgaactct gtccaacata aacagtactc cctttttccc actagagttc atgtctattt
     6421 tatatttaaa attaagaata acaatgctcc aatctattta ttctctgact tcggaatcca
     6481 actatccacc aacagccgat gctcatccct ccatttacgg gctatttctt cttcatccat
     6541 cctggcatcc ttcatagctg tcataaaaga gctaagttct tctgtcgtta gtttgatgtt
     6601 gccaaagaat tcggcagcaa acggatcttt ctcactgaat cctttccatg caatagcatg
     6661 tatttcttcc aagtctccat atactttctt cggatcatcc aagaatttca agtcaaactg
     6721 gtcgaacatc caatgcggtg tccaccccgt aatgacaatc cattctcctt tgtccatcgc
     6781 ttttttcaaa gaagccagca tggtggaact acttgaagtc atgagggtat acccatcaag
     6841 tccgtaagca gcaatggcct tatcggtcgt cttcattatc cctgctcccg catcaattcc
     6901 tactatttca gaggaaaaac ggtctttatt agcttccagc tcattaatag agtggatcgt
     6961 aacatattga ggaacaacca gtccgacgcg agcttctccg tatacctccc caaaaaattc
     7021 gatgctgtct ccatactgat ccatataatc tttcatcgtt attggtaacc atgcatccag
     7081 aaacacatct gatttctttc ctgacataga tacaaaaata ggggcaagat cagcattttg
     7141 caattcaacc tcatatccat gctcttccaa taccacctta gccaaatgac tcatggcaat
     7201 accttccagc caattggcat aggctatttt tactttcttt ttctctaagt ctgaattagt
     7261 acaggaagct agcaaaagca tagctgacaa tactattcct actattttat atattctcat
     7321 acgtatttta tcctttccgt ttagttctta ttttttcgtc ctgccattcc ttgcgtgata
     7381 cggtctaaga tgatagctaa aataacaact gctataccac cttcaaaccc aagtccgatt
     7441 ttcatttggg taataccttt caatacaatt tctcccagac caccggcagc aatcatggca
     7501 gcaattacaa ccatagaaag cgacatcatt attgtctggt tgacaccagt cagaatggtg
     7561 ggcaacgcca aaggaagctg cactttatac aataactgcc aacgggtagc tccgaacgaa
     7621 cgggaagctt ccactacatt tttaggaact tgccggattc ccaatccggt aaggcggacc
     7681 acaggaggca tagcaaagat aatggtggca aacactcctg gcactgctcc caatccgaaa
     7741 aacaaaacag caggaatcag ataaacaaaa gcaggcatcg tctgcatcaa gtcgagaaca
     7801 ggacggagta ttttctctgc acgcgaactg tttgccgtcc atactcctaa aggtacacca
     7861 acaatcaggg ccagacaggt agatgaaaaa acgagagcta gagtttgcat ggtagcctcc
     7921 cagaatccca ttccatagat cagtaataat cccaatgcgg tgaaaattgc cgtaccgcgt
     7981 cctgctttca tccatgcgag tgcagcaagt accaaaatgg ttatataaaa aggtattccg
     8041 aaaagtatgt gttggaatcc tataataaaa ctaccgatgc ccgcattcac ggcatcaaag
     8101 aaagtggaaa aatgtatcat catccaattg atggccatct ctatatattg tcctatattt
     8161 atcataaatc tattgcgttt tgaattattt cgtttatttc ttctttatct ttcccggtca
     8221 cttcgatgat taaggatgaa agcgggattg ttcctaaaaa ctcgcgcgtc tcatcaatca
     8281 cccataccgg cgaattgctc tttgtcatta gaggaagtat atcctccaac accgtatcct
     8341 ccaacacaga atgtacttct gtacgcacaa tcgtttcaat ggatttttcc tgtttgctac
     8401 gtaacttaag caagtcgttc agacgtactt ctccgaccag tttatcatcg gcgtctatga
     8461 caggtaatac ggtgatattc ttcgcacgca tcttacgaat caatacttcg ggaccttctt
     8521 tcttcagacg ggccaccaac ggtttgtcaa tcattaaaga agaggcggta ataattttgc
     8581 tcctatccac gttttcaaca aaacgggcta cataatcgtt agccggttca gtcaggattt
     8641 cctccgaagt acctacctgc accacttctc cgtctttcat gatggcaata cggtcaccta
     8701 gcttaattgc ttcactcaag tcgtgggtaa taaaaacaat cgtctttttc atctttgatt
     8761 gcaaggccag tagttcatcc tgcatctgta cgcgaatcag aggatcgaga gcagagaaag
     8821 cctcatccat taaaagcact tcaggattat tagccagagc gcgagccagt ccgacacgct
     8881 gttgcattcc accggaaagc tcgcctacca tctgattttc atatcctttc aatccgacaa
     8941 gcttcatgct ttccatcgct ttcttctcac gttcctcttt cttcactccc tgaagttcga
     9001 ggccgaacgc gatattgctc aatacggaac ggtgaggtaa cagaccgaaa ttctggaaaa
     9061 ccatcgccag ctctttccga cgaacctgca ataattcttt ttcggaaatt ttagatatat
     9121 ctactccgtt tacaagcact tgcccggtag taggacgtat cagacgattg atacaacgca
     9181 gtaatgtcga ttttccactt cccgagagtc ccattatcac gaaaaactct ccttcattaa
     9241 ttgaaagatt ggcatctttc actcctaccg tacaaccggt atctttcaga atttcctctt
     9301 tactcttatc ttttttcaac atcttgaggg ctttctgctt ctcgttacca aagataaggt
     9361 acaaatcctt tatttctatt ttactcatat aatatattgg tttagattat aatatttgtt
     9421 ttgttttcaa ctgccgcatt ccttattctc acttacgata aacaagttga atgttcgcat
     9481 ggttcagtca tgtcacatga taacatgacg gtccgacgtt ttttaaatgg ttaaaaaaaa
     9541 cagacagagt agtttaaaag gaatagaatt tgataagatt atcctcttaa tgaacagtag
     9601 aaaacagtat tttcataaat aaataacagt ctgttcttgc atattgttgg cacaaaggta
     9661 aggaaaatag attaaatatg caaatttcat tcaggtacgg agtaattcca aagatgcttt
     9721 ttcaagtcta cgcatccatt ttgtttgaaa gagatccctt cttccaacaa gagttgtttc
     9781 tgctctgtcc aacccggaac aagccgtccc gacgcattga caacccgatg acaaggcgca
     9841 gataaatcat ccggaatctg tttcaaagca cgccccacca tacgggaaca ttgagacatt
     9901 cccaataatg cggcaattcc cccataggta gaaactttac ctaccggaat ttctcggaca
     9961 acctgataca cctcttgaca aaaggatgcg gaaaggctcg ccttatctac tttataatct
    10021 ttcatcactc aaacattact ttatttcagt tccaaaacta gataaaaaga aaagaatttg
    10081 caaataataa aagcatttca aataaaatat gcaactttat ttgctttatt tacaaataat
    10141 cccgaccttt gtacccatta aaagcaaccc tattattaac aaaacaagca ctgctgttat
    10201 gaaaaagaaa actatcctgt tcgcttcttg tttattggga gcactggctt tcagctcctg
    10261 tgagaagaac ctttatgatg aaagtaaaca acccgagaaa gaaaagaaga tgactgactt
    10321 ggaagtacct gccgatttcg actggaaagg ttctcaaaat gccaaagtga aaattgccag
    10381 tcaatcaact gctactattt ctgtatttct agaagaaaat tgcaatgaag aggctttgat
    10441 gcttcgaatg gatgtcgatg ccaacacatc aaaattggaa ctcccaattg aaattcctgc
    10501 atatataaaa aatgtgtatg taaaatatgg taatggctct gaaatacaaa ctgttcctgt
    10561 tgaaagtaat ggtactattt ctatagtagt acctgctaac gctacggcat tatccagagt
    10621 taccacaaga gctaataaag aagttgaaac gaacaacatc ttcaattatc cgggatatgg
    10681 caacggaact attatgttcg aagatatgta tccagcttta ggcgattatg attttaatga
    10741 ttttgttgca tggtataatt tccaaattga cggtttttat tggagtcaca atcaatgtta
    10801 tgcagaatac ttaatgatag gattccaaat cagagctata ggaggtatat atgactacaa
    10861 tccttatatc cgcttggcag aagtacaata taatgaactt gatttagaag aaactcaaat
    10921 gtatcttgag cgtaacaatc ctgaagaggc tgaaaatatc aaaatcctaa aaggcccaaa
    10981 aggggaattg attatttcac taaagaaacc ggccattcct aacggataca agtattataa
    11041 tacggaggta aatgaaaaaa caaagcctaa aaaaatgatg gccatttact tggtgttcaa
    11101 ctcacctgtt aacgttaaaa gcctacaaga cagtaaaatg gacttttata ttgcaaaaac
    11161 taataaagga caagaaatcc acttaaaagg ttatagcccg gtttattata acagcaacga
    11221 aagttatgta aatgaagaca actttatatg gggattaaaa gtacctgcat ctttacatca
    11281 tgccagagaa gaagtaaact tcttggaagc atatccagac tttgaacaat gggtaacatc
    11341 gggaggtcaa gagaaccaaa gatggtggaa taagccaaaa acgaataagt tgattatgaa
    11401 ttaataaata tacagtaaat catatactga attaaataag aggtaaggta tgtcaataga
    11461 tttccttacc tcttattttt atcatatgaa ttccatagaa gtataaacag ataaatgctc
    11521 accaccaaat tttgcagatt ctatcctatc ctttcctctt caacaaatct gtcggactct
    11581 ctccaaactg ttctctataa catttagtaa aataagaagg agaactaaaa ccaacttcat
    11641 aaccgatctc tgccactgtc atatccgacg aggcaagcag agaggcagct ttcttcaaac
    11701 gagctatacg aagcagttca ttcggagaat aattagtcag agatttaatc ttgcggtaaa
    11761 gttgcacacg acttaatccc atatccttac ccaaatcttc tacattcaaa tttgaatctc
    11821 ccatctttgc ctcaatcaga gctttgaatt tttccacaaa gtctttatcc atatcacaga
    11881 catcctcttt cgccaacgtt tgtccgtcac caaaaaactg tttcaggcgg cggtgtgaat
    11941 ctatcagatt acgaacgcgt gccaatagta attgcgaact gaaaggcttg gagatataag
    12001 aatctgcacc accatcatac ccttgaattc gttgttcatc caaagaacaa gctgtcaata
    12061 ggataacagg aatatgacag gtttgtaatt cgcttttcaa gcgacgacaa cattcaattc
    12121 catccattcc gggcatcatt acatcggaga taatcaagtc cgggacatat ttcatagctt
    12181 tacgaatacc ttccgagccg tatgcagctt ctataacagt ataatcagtg tgaagcaatc
    12241 catgcacata taagcgaata tcagcgttat catcaataat cagaacgcaa ggtttggaag
    12301 agtcgtaact tttttccaat tcctcttctt cgtaagttaa agcatcattc aagctcgaag
    12361 aaccggaata accagaagtt gcaggagtta cgggagcccc agcaacggca gaggttgcag
    12421 catcggtaga ggttacagaa gtagcaggca cagagaatgc cggagagttt tctgaaacaa
    12481 cagtctcgca agtctgtaca ggcaaatcaa cggtaaagat agttccttgc ttttcatcac
    12541 tttccaccgt gatggtacct ttatgcaatt ccacaaaagc ctttaccaat gccagtccaa
    12601 tacccgaacc ggcatggtgc atatctatct tatagaaacg gtcgaaaata ttccggatat
    12661 gctccgcaga aatcattgag ccggtattgg caacagtaaa gcgaatccaa caatgatcgt
    12721 ctttagtcag ggaagataag cgtacagtta cttttccatt ctctggagta aatttgaaag
    12781 cgttggaaag gaggttgaaa tagatgcgtt ccaacttttc tacatctgcc aatgtgcggt
    12841 aatccgtatc cggcatataa tcgaatgaga aatgaatatg tttcttccgg gctgctgcca
    12901 tgaaagactc gttccatccc tcaaaagaag aaagaatgtc taacgaaata ggagtatatt
    12961 ccatttttcc attctcgtat ttacgaaaat ccagaatctg attgacaaga cgcaagagga
    13021 tattcacgtt tcgctgaact aacaataaca ttcggcgctg atcttcactc aaagacgaat
    13081 cagccagtaa atgctctacc gggtcggcaa ctaatgtcag tggagtacga aaatcgtgag
    13141 atatatttgt gaagaaaacc agcttggcat gagtcgcttc ttccagttga tgagaaagct
    13201 ggataagctg atcccgctgt tcttcgagtt tgtcacgctg ttcttcaaga atatcccgtt
    13261 gctcttcgag tttatcgcgc tgttgctcta cttgtttctt ctgttcggac aactctttat
    13321 tcaggcgatt cttggaacgg agggatttat agactaccaa caacaatccc gctactaata
    13381 aaagaataac caagccgcca tacatcacga cctgctgcgt agctacacgc gacagatacc
    13441 caccgatacg tccgttcaat gtttcaatct tctgatccag ttccgagata tgggtagtct
    13501 gaagttgcat aacgtgcgcg ttcgtgcggt ctacaacggc agtattcatg accgtttcgc
    13561 gaggataaga cttcttctca agaatattca tggccagttg catcactttg tccccattag
    13621 tcggataaat aaaagttgca tccagcacat tgtcaagcac caattcaagt ccgtttcctt
    13681 tgccgggcag ggcatcaatg ccaacaaaaa tcatttcctt ttcacgtccg gctttcttcg
    13741 cagcctgata ggctcccgga gcgatacggt cgttatgtgc atacaccgca tcaatcttcg
    13801 gatgacggtg aagcatacta tccatttcca cttctgccgg ttcacgttcc caggcagcat
    13861 ccgctttatc aatcagtttg atatccggat aattgctgat agcggccata aatccctgat
    13921 ggcgctccat agcaggggtg gaaccaccca gtccggtaag ctccactaca ttccctttcc
    13981 ctttcagact tgatgcgata taatttccta ccgcacgacc tatttcataa ttatcggcac
    14041 caatataggc agtatattta tcagaaagta tcttccggtc tacaagaatg acgggtattc
    14101 ctttctgata ggcctcctcc acaattggag tcatgggagc cgcttcattg gcggaaatta
    14161 tcagtaaatc aactccttta tctataaaat aatgaacatc ttccgcctgc ttacggttat
    14221 catccgccgc cgaacggatt tcaaccgaca ctccatcata aaacatcgct tcgcgaagaa
    14281 tctcatcatt catcttgtgc cgccaagagt catcactaca ttgggccacc ccaatacgga
    14341 aacgaggcgc atcctgacga caggccgcca agcccaaaag acaaaacaag actgttatcc
    14401 acttcatata tttcatcgct tcaatcattc cctttctttc gtatatcttt tgtatttctt
    14461 tctgtaatcc aaatttctct ccccgcatta tttgcattca ccaccgggaa atacatcagt
    14521 tccactttca cagggttcag cgtgtatttt ccagtaaagc gtgaaagcaa aggaaccgta
    14581 aactgataag tacctaccgg taatttttcg ctaaagataa cagttttctc tttaaaatac
    14641 tcacgataca cttcagaacg ggagaaatta acaggttttg aggcataact acaacctgcc
    14701 ggaacaggaa cttcgagcat cacatattgc gcaccctcct gtttcacctg caaggtaact
    14761 gtcaatgtaa caggtacacc cgccaccaaa gagtcttttt ccaaagtcgc ctccaccttg
    14821 aaagcatcac tctgacgagc attcatcaca cgcttcattg aatagacact atacaataaa
    14881 ggctcttttc ccgtttttga aataagcaga ctgtcgcctg ctgtcagccg ggcatgataa
    14941 ggaaattccg taattcgttg atgatcctta ccgctcacaa acaccgacgt tcctgacatc
    15001 cctccggaac ctgccagcaa atcggtcaga acagttgcca cagccgaaga agcctgatac
    15061 gtattccatc cgcgctcctt agtccgcaaa atatacaatt gcatattttc tttcaactta
    15121 cacagggaag ggtcattttt aataatccgg taggctatca atgtatttat catctgattt
    15181 ccctcccaat aataagtacg ccgtccgtcg tcacagtaaa caccttccag catatccttt
    15241 ttcagataag gacgtacgct atcacccaca ttcaccgaat ccacctgttg cttgatttcc
    15301 cagagaagca gcttctcttt caagtatgaa agaggacgat aatacttgtt tctatttgcc
    15361 aacgagtctt ctttctgttc caattgccgg acgaaaggtt ccaataatct gactgccgaa
    15421 gaataatccg cctctacttt ccactcatgc agagcatgaa gtatttctat atcttccagt
    15481 ttcattcctc gataaggacg cgtatgagca tactccactt tcaaaccatt cagattcaac
    15541 tccacaggat aacctgcatc ttgcgccatc ttcaaagccc gcagaatatg cgcagacatc
    15601 cagaaagaag tattttcaga gttcccccac cacgaccata actgatgttt gttctgatga
    15661 ttcgtcagtc gatggatgat aggtcgaatt gctttatcta ctttcacctt ttcaccctta
    15721 ctctgcatat actgttggta agccaacaaa ccgattaact tggatgccag ctgctcattg
    15781 cacaaatatt tgtatcctgt caagtaattc actgattctt tatagatgtc caactgattg
    15841 tcagtgatac tcaccatcac ttcttcatcc tcgccggatt gcactttaac cgtctttgca
    15901 tcggacagaa tacccaatgt gccctccgcc aattcagttc cctgtgccag tatcggaatc
    15961 gtatattcct ctccatcctg atagccatcg tcgcgagtga aaagatagct gatggtcacg
    16021 ctatcggcat gaactgcctg catcggcact gtttcatgaa atccctccat gaaactcact
    16081 tcctgccgtt tcaacgtatc cgttccgacg cagaactgtg tctttccggc tatgtgctgc
    16141 ccatccagat aattgcggat agtcccgacc accgtactct gatccccctc caccaagaag
    16201 cggggagttt tcaactccgc catcaacggt ttgtaagagc ggacgaaacg tcggaaagta
    16261 cccgtttgca aacgacggtt catgccataa acgacagttt c
//
