LOCUS       c00042_gnlPro..        14688 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PLOPOAKI_42.
ACCESSION   c00042_gnlPro..
VERSION     c00042_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 23:29:03
            Original ID  :: gnl|Prokka|PLOPOAKI_42
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14688
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14688
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2455:7017]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2456..7017
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14688
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14688
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             2..829
                     /locus_tag="ctg42_1"
                     /transl_table=11
                     /translation="RQYANATLLRYMAQGAVEYAKELGCAHPEIVLHLDHGDTFETCKS
                     CIDSGFSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELGVLAGVEDEVSSDHHT
                     YTDPEEVIDFATRTGCDSLAISIGTSHGAYKFTPEQCHIDPATGRMVPPPLAFEVLDAV
                     MEKLPGFPIVLHGSSSVPEEEVETINKFGGALKAAIGIPEEELRKAAKSAVCKINIDSD
                     SRLAMTAAIRKTFAEKPAEFDPRKYLGPARDNMEKLYKHKILNVLGSDNKLAE"
     CDS             complement(908..2242)
                     /locus_tag="ctg42_2"
                     /transl_table=11
                     /translation="MKRIILLAFLCTTTLVMAQRINHVQEAIANYDYEAALTLIAKEKP
                     TIPLLLQKGKAQRGLGMNTEALSTYQEIITNDTANTRAYIEAAECCRSLAKYQQALKYY
                     EQALDLNPENKYVRIQYIGLLLSLQKFQDALGESSLMTEKDSSAIALHLQAQSFEGMGE
                     LLPATGCYYNIQEKYPDDYLAAAKLAALNIAGSYFNEAIEATEKYRQIDTTNIAVNRQN
                     ALAYCLNKDYPTAIQRYEYLVSQGDSSFHTCYYLGISYYAEEKYYEAHDFLEAARKHDP
                     ENVNLLYYLGRACAKTSWKKLGVEYLEKALDLTIPKDSNMVRLYIGMTDCYKMAQMPKE
                     QIESIRERYRKYDKQNHKLLYDMAFIYFYSLKDKKNTERCLEAFLKTRPKEDKEEEAKL
                     NERGELVLGTKNYYNAAANWLKDIQSKQKIEDFFLGGNVPAQKPE"
     CDS             complement(2456..3616)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg42_3"
                     /sec_met_domain="OAD_beta (E-value: 1.8e-154, bitscore:
                     503.5, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFINFLGNNLADFWTYTGFANATVGHIVMILVGLFFIYLAVAK
                     EFEPMLLIPIGFGILIGNIPFNMDAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALEMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKHERVIRMKPPRAVSHTEKVIFP
                     IIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDTITILLGLTVGAS
                     TQASEFLTLDSIKIFALGALSFIIATASGVIFVKIFNLFLKKGNKINPLIGNAGVSAVP
                     DSARISQVVGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             complement(3618..4052)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 66.7; E-value:
                     4e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg42_4"
                     /sec_met_domain="Biotin_lipoyl (E-value: 7.8e-22, bitscore:
                     66.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNSYKVTIGDIEDNIAHVEVNGTHYKVEMEKQPKTA
                     PKPVVVRPMPNSPAAPTTPVVKPAAPSTGKSGVKSPLPGVILDIKVNVGDTVKRGQTII
                     ILEAMKMENNINADKDGKVTAINVNKGDSVLEGNDLVIIE"
     CDS             complement(4077..4997)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg42_5"
                     /sec_met_domain="OAD_gamma (E-value: 3.3e-15, bitscore:
                     46.2, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLLLLIGLTSCGEQKSNNKLLLNEVLIDNQNNFQD
                     DYGLHSAWIEIFNKSYGSADLAACLLKVSSQPSDTVTYFIPKGDILTLVKPRQHALFWA
                     DGEPNRGTFHTSFKLNPETANWVGLFDSGRKLLDQVVIPAGTLGPNQSYARISDGAADW
                     EVKGGSKDKYVTPSTNNKTLDSNAKMEKFEEHDSVGIGMSISAMSVVFCGLILLFIAFK
                     VVGKVAVNLSKRNAMKAKGIDKVEAKELSQAPGEVYAAISMALHEMQDEVHDVEETVLT
                     ITRVKRSYSPWSSKIYTLRENPNRK"
     CDS             complement(5029..6582)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg42_6"
                     /sec_met_domain="CT_Btheta (E-value: 1.9e-290, bitscore:
                     952.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERRAVARIGGGEKAIAKQHEKGKYTARERLAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYVFAQDFTVSAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAKTEEEGFELIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDSPT
                     KPYDMYEVIGAIVDNGEFLEIQKDYAKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKDQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLSNPAKKHGNIPL
                     "
     CDS             complement(6613..7017)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg42_7"
                     /sec_met_domain="Glyoxalase_4 (E-value: 1.3e-24, bitscore:
                     76.4, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGETKIELLEPTCPESTIAKFIENKGAGVHHVAFAVEDGVANALAEAESKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             complement(7191..8189)
                     /locus_tag="ctg42_8"
                     /transl_table=11
                     /translation="MPLKLTTYYRGKDIPDLPGTNTFHSKELFQIYESTPGYTPLLIVA
                     TEEGRPVARLLAAIRKTKKWLPSSLVKQCVVYGAGEFLDTSLPASKEKEEEIFGEMLEH
                     LTQEASRTCILIEFRNLDNSMFGYRFFRKNDFFPVNWLRVRNSLHSTQKAEDRFSPSRI
                     RQIRKGLKNGAKVVEAHTVEEIKEFSRMLHKVYSSRIRRYFPANDFFRHMNSMLIRGKQ
                     AKIFIVKYKEKIIGGSVCIYSGENAFIWFSGGMRKTYALQSPGILAVWKALEDAHERGF
                     RHMEFMDVGLPFRKHGYRDFVLRFGGKQSSTRRWFRISWPWLNNLLVKFYV"
     CDS             8438..11632
                     /locus_tag="ctg42_9"
                     /transl_table=11
                     /translation="MRENAFVEVWKTQHRRVSMILGLTLLCAPSAISVYAENGVNDITV
                     QAVMQTKTVKGTVLDENGEPLIGVSIVVKGTSTGTITDFDGKFSINLPAGSKELVVSYI
                     GYKEQAIIVSGNAPLNIKMVPDTQALDEVVVIGYGTVKKRDLTGAVASVKSEDITMNPG
                     VNPMDALQGKIAGLDITNSSGQAGSSPTVQLRGTRSLQLDEDGNISSDAFKPTYIIDGM
                     PGDIATLNPNDIESIEVLKDASSTAIYGSSGANGVIIVTTKGSKSGKPVINFNAYAGTT
                     LGAKVPKMRTGDSYINYIKDSYKPVGTTNEEEIFGERYDAIKNNQWVNWGDEVLHSGLK
                     QNYSISVAGGTEKTKAYFSLNYTDEKSMYENDDYKVYSTRVRIDQEINKWMNAGINVQA
                     SFSNKNSRNAVLERALFATPLGTPYNEDGSITEFPIPGSSSDPNPLADEQDGVYKNNTK
                     AGRAYVDAYLEWKPVKGLSVKSQLGGSYSQSRAGKFMGEGSYNVLKGSTVAYGEATNKT
                     GYNYKWENIVTYHNTFNKDHDLTVTGVTSWNYNQSEEYYVYGENPATNDMLWYALQNAD
                     NKKLNSKYLMSKGMGFIGRVNYSYKGKYLFSASSRYEADSRLSKDNRWNLFPAVSVGWR
                     ISDEAFMAGTKSWLDNLKLRVGYGVAGTTAGIAEYSSMASLENVTTSLGGMTVPSAKFT
                     EYITNRNLTWEKTHDLNIGIDASFLNNRIDLTVDLYRTKTTDVILSQALPTSIMGNYTG
                     STTYKMNKNAAETENRGIELALNTRNIVKKDFTWSSTVTFTANKEKIKSLIEGQDMMFN
                     AKKGDMVFKVGEGVGSFYRYKVLGIWQYSEKETAALFGCEPGDIKLDLPSVKKDGNGYY
                     YMNPEGERVDITAENPYGVRADYDRQVIGRNTPDWTLGFKNNFRYKDFDLSVFLYARWG
                     QMMNYGSVIGKYSPNPDYNVPTYFTYYDKTIEADQDVLFYAIDKSKDRSAYEGYDSMYY
                     VDGSFFKLKNVTLGYTLPGKLTKRFGISNLRVYATMTNLFTYSPNKYVKNYDPEMNGSI
                     NFPLSRDCIFGLNLTF"
     CDS             11644..13599
                     /locus_tag="ctg42_10"
                     /transl_table=11
                     /translation="MKKIYSLVLLVAGVFSWGSCSLDEVNPNNSGQFSDGSYTLETYKA
                     FTNSCYTALINNIYQSSDYLVCTEAGTDIWEEPKSGSSYQRYHSYNGMKTDDSYYYKVW
                     QYSYLCINSCNIVIDGAENVTGDENEINECVAQARCLRAYYYMNLVEQFGNVDLQLKAA
                     DSENISFDAHRSTVPEIYAAIIEDLKFAVENLPVSFSDYYSRVTKKSAMGLLARAYING
                     AGYDLKDTDGVSFLEKAYDTATTMINNKAIYEWYMHPAFADVFNENNNRNNEEALFIAA
                     GAERNSDAYTNGNYSQSEMFRHFLPSLGTYTDLGLVDKTSNFVYGRPNSNIFLPSKYLM
                     DCFAADMNDSRFRYSFISAYSSYSIPAWGATYEYGGSACAKEITSTLATKFGIPASNIG
                     KKVYPHFNLESNSTADANYCQLAIWNADGTAKTTQDKTDGNILHPAMPLDPAEAHQYAV
                     YCSLKTLTEEEKAQYPGLVLNVFDLYDENGTARATYDKPSAASALWLSIYPALSKFNMP
                     GNKFVGRDVQRKTVDVMIMRMAEVYLIAAEASVRLNKGDAAKYINVLRTRAGAGTVSES
                     QVDLNYVFDEYARELCGECGRWYLLKRNAAFETRLAAYNKRAAEHFKKEFYLRPIPTKY
                     LDAINNPAEFGQNAGY"
     CDS             13788..14330
                     /locus_tag="ctg42_11"
                     /transl_table=11
                     /translation="MIEEMLAYNREFVKNEGYKEYITNKYPDKKIAILSCMDTRLTALL
                     PAALGIKNGDVKMIKNAGGVISHPFGSVIRSLLVAIFELGVEEIMVIAHSDCGACHMHS
                     EEMLEKMKARGINADYIHMMSFCGVDFHSWLDGFEDTEKSVRGTVDFIVHHPLIPSDVK
                     VHGFIIDSTTGELTRIV"
     CDS             complement(14444..14686)
                     /locus_tag="ctg42_12"
                     /transl_table=11
                     /translation="IAYYPHPKSCIYKLNSRFIMKKRITQDDYIKANRKASREAEIKEH
                     GHPVCYKRVHESKKVYNRRKIKAADKKLPYFFHLG"
ORIGIN
        1 tcgtcagtat gctaacgcta ctttgttgcg ttacatggct cagggtgctg tagagtacgc
       61 aaaagaatta ggttgcgcac atcctgaaat cgttcttcac cttgaccacg gagatacttt
      121 tgaaacttgc aaatcttgca tcgattcagg tttctcttca gttatgatcg acggttctca
      181 tcttccttac gaagaaaacg ttgctttgac taagaaggtg gttgaatacg ctcatcagtt
      241 cgacgtaaca gttgaaggtg aacttggtgt attggcaggt gtagaagatg aagtttcttc
      301 tgaccaccac acatacactg accctgaaga agtaatcgat ttcgctactc gtacaggttg
      361 tgactcattg gctatctcta tcggtacttc tcacggtgct tacaagttta ctccggaaca
      421 gtgccacatc gatccggcta ccggtcgtat ggttcctcct ccattggctt tcgaagtatt
      481 ggatgctgta atggaaaaac ttccgggatt ccctatcgta cttcacggat catcttcagt
      541 tcctgaagaa gaagttgaaa caatcaacaa gtttggtggt gctctgaaag ctgctatcgg
      601 tattcctgaa gaagaattgc gtaaagctgc caagtctgct gtttgcaaaa tcaacatcga
      661 ctcagactct cgtctggcta tgactgctgc tatccgtaag actttcgctg aaaaacctgc
      721 tgaattcgac ccacgtaagt atcttggtcc ggctcgtgac aacatggaaa aactgtacaa
      781 gcacaaaatc cttaacgtgc tgggttcaga caacaaattg gctgaataat cacagattat
      841 cctattatat agaaaggctg caatcgtttg acggttgcag cctttttacg taatattctc
      901 tatctgctta ttccggtttc tgagcgggca catttcctcc caagaagaaa tcttctatct
      961 tttgcttact ttgaatgtct ttcagccagt tagctgcagc attataataa ttcttagtgc
     1021 ctaaaacgag ttcgcctcgt tcgtttagtt tcgcttcttc ttccttatct tctttcgggc
     1081 gtgtttttaa gaatgcttcc agacagcgtt cggtattttt cttgtctttc agcgaataga
     1141 aataaatgaa agccatatca tagagcagct tatgattttg tttatcgtat ttccggtagc
     1201 gttctctgat cgattcaatc tgctctttag gcatctgtgc cattttgtag cagtcggtca
     1261 tgccaatata gagccgtacc atattactgt ctttgggaat agtcagatca agcgcttttt
     1321 cgagatactc tacgcctaac ttcttccatg aagtcttggc gcaggcacgg ccgagataat
     1381 aaagcaggtt tacgttttca ggatcatgtt ttcgggcggc ttccagaaag tcatgtgctt
     1441 cgtaatattt ctcttccgca taatagctga tacccagata ataacaggta tgaaaagaac
     1501 tgtcgccctg gctcaccagg tattcataac gctggatagc ggtaggataa tccttattca
     1561 gacaatatgc cagtgcattc tgacggttga cagcgatatt ggtggtatca atctgccgat
     1621 atttctccgt ggcttcaatt gcttcgttga aataagaacc ggctatgttc agtgcggcga
     1681 gcttggcggc ggcaagatag tcgtcggggt atttctcctg tatattatag tagcaccccg
     1741 tggcggggag aagctctccc ataccttcga aactttgggc ctgcagatgc aaggcgatgg
     1801 cggaactgtc tttctctgtc atcagactac tttctcctaa agcatcctga aacttctgta
     1861 aagagagcag tagtccgatg tattgaatac gcacatattt gttttccgga ttcagatcaa
     1921 gtgcctgttc ataatatttc agtgcctgtt ggtatttggc caatgaacgg cagcattcgg
     1981 ctgcttcgat atatgcacgg gtattggcag tgtcattggt tatgatttcc tgataagtgg
     2041 aaagtgcttc tgtattcatc ccaagtcccc gttgtgcttt acctttttgc aagagtaggg
     2101 gaattgtcgg cttttctttg gcaatgagag tgagagctgc ctcgtaatcg tagtttgcta
     2161 ttgcttcctg aacatgattg atgcgctgcg ccatcaccag ggtggtggta caaaggaagg
     2221 cgaggagaat aatccgtttc ataaatattt attttagtgt gtcgtaacaa agacgcaaga
     2281 tgctaaaaaa tatcgtattt acgaattatt cgtagccttt ttggaataga ttaacggaat
     2341 gataagagaa gataacataa tgataagtgc ggatattgca tctaaaacag caatatccgc
     2401 acctaatatt ttgtcccggc attccgaatg gaaacctgac aggggcacct tgtccctaca
     2461 ttaagaatcc taacaggata ccggcagcaa cagccgaacc aattacacct gctacgttcg
     2521 gacccatagc gtgcatcagc aagtagttgg taggatcata ttccagacct acaacttgtg
     2581 agatacgtgc agagtcggga acggcagata cacctgcatt accgatcaac ggattgatct
     2641 tattgccctt cttgaggaag aggttgaaga tcttaacgaa gatcacacct gatgcggtag
     2701 caataataaa tgacagtgca ccgagggcga agatcttgat ggagtcgagt gtcaggaact
     2761 cagaagcctg agtagaagca cctacggtca aacctaacag gatagtgatt gtgtcaatca
     2821 gcggaccgct ggctgtgtta gccagacgac gggttacacc actttctttc aacaggttac
     2881 cgaagaacag catacccaac agaggcagac cggaaggaac caggaagcag gtcagcaaca
     2941 gaccgataat cgggaaaatc actttctctg tatgagaaac ggcacgtggc ggtttcatac
     3001 ggataacgcg ttcgtgtttg gtggtgagca gacgcatgat aggcggctgt atcaccggaa
     3061 ctaacgccat ataggagtag gcggataccg caatggctcc cattaagtta ggtgccagct
     3121 tggacgaaag gaagatagcc gtcggaccat ctgctccacc gatgataccg atagcaccgg
     3181 cctgcatcgg gtcaaatccc atttccaatg cgatcatgta tgcaccgaag ataccaaact
     3241 gggcagctgc accaatcagc atcagcttcg gattggagat cagcgccgag aagtctgtca
     3301 tggcaccgat acctaagaag atgagcggtg gataccagcc ggacgttact ccctgataca
     3361 atatgttcaa tacagaacct tcttcatata taccgacttt tagtccggcg tccatattga
     3421 agggtatatt accgatcagg ataccgaatc cgataggaat taacaacatc ggctcgaact
     3481 ctttggctac agccaaatag atgaagaaca agccaacgag gatcatcacg atatgaccaa
     3541 ctgtcgcgtt ggcaaatccc gtgtaggtcc agaagtcggc aaggttattt cctaaaaagt
     3601 taataaaatc tcccatatta ttcaataatt acgaggtcat taccttcaag aacagaatct
     3661 cccttgttga cattgatagc agtcacttta ccgtctttgt ctgcattgat attgttttcc
     3721 atcttcatgg cttccaatat aatgatagtc tgtcctcttt tcactgtatc acctacattt
     3781 actttgatgt caaggataac gcctggtagc ggggacttaa cgcctgattt gcctgtagaa
     3841 ggagcagccg gttttactac cggtgtggta ggagcagccg gtgagttagg cataggacgt
     3901 actactaccg gtttgggagc agttttcggt tgtttctcca tttctacttt gtagtgcgta
     3961 ccgttcactt ctacatgagc gatattatct tcaatatctc cgatggttac tttgtatgag
     4021 ttaccgttga ttttatattt atattctttc atcgttttat ctttttaggg aatgatttac
     4081 tttctgttag gattttcacg caaggtgtaa atcttcgaac tccacggtga ataactgcgt
     4141 ttcacacgag tgatggtcag caccgtttct tctacgtcat gtacctcatc ctgcatttcg
     4201 tgtaatgcca ttgaaatagc agcataaact tcacccggag cctgtgaaag ctctttcgct
     4261 tcgactttat cgatgccttt agccttcatc gcattgcgtt tgctcaggtt gacagcaact
     4321 ttacctacca ccttgaaggc aatgaagaga agaatcaatc cgcagaatac tacgctcatg
     4381 gctgaaatag acataccgat accgactgag tcatgttctt cgaacttttc catcttggca
     4441 ttactgtcaa gggttttgtt gttcgtgctc ggggttacgt atttgtcttt gcttccgcct
     4501 tttacttccc agtctgctgc tccgtcgctt atgcgtgcat aagactggtt gggacctaaa
     4561 gttcctgctg gtatgacaac ttgatcaagt agctttctgc ctgaatcaaa aagaccgacc
     4621 caattggctg tttcagggtt cagtttgaag ctggtatgga aggtaccacg attaggttcg
     4681 ccgtctgccc aaaataacgc atgttggcgt ggctttacta atgtaagtat gtcacctttt
     4741 gggataaaat aggttactgt atcgctcggc tggctgctta ctttcaataa acaagctgct
     4801 aagtctgcgc taccgtatga tttgttgaat atttcaatcc atgcactgtg caagccgtag
     4861 tcatcctgaa agttgttttg attgtctatc aggacttcat tcagcaatag cttattgttc
     4921 gacttttgct ctccgcagga agtcaatcca atcagcaaca gcagagaaag gaatattccg
     4981 attttggttt tgttcataat cgttcttgtt ttaatgtgaa aagtaggatt acaacggaat
     5041 attaccatgc ttcttagccg gattgctcaa tttcttagtc tgcaactgct gcaaagcacg
     5101 gatcacacgg aaacgtgtgt tgcgcggttc aatcacatcg tcgatgtagc catatttagc
     5161 tgcattgtaa ggattggcga acaatttcgt gtattctgct tctttctctg caaggaattg
     5221 agcagggttt tcctgatctt tggcttcgcg tgcgtacaat acttctactg ctcctgctcc
     5281 acccattact gcgatttcag cagtcggcca tgcgtagttc atgtcaccgc gaagttgctt
     5341 acagctcatt acgatgtgag aaccaccgta ggatttacgc aatgtaatcg taaccttagg
     5401 cacagtagct tcaccgtaag catacaacag tttagcacca tgaaggataa cgccattgta
     5461 ttcctgacct gttcccggaa ggaatcccgg tacgtctacc aacgatacga taggaatatt
     5521 gaatgcatcg cagaaacgaa cgaaacgtgc acccttacga gatgcgttgc tatcgagcac
     5581 accagccaga tacttaggct gattagcaac gatacctacc gattgtccgt tgaaacgggc
     5641 gaaaccgatg atgatattct ttgcataatc tttctggatt tcaaggaatt caccgttgtc
     5701 cacaatagcg ccgatcactt cgtacatgtc atacggttta gtagggctgt cggggataat
     5761 atcgttcaaa gaatcttcca gacggtcgat tgggtctgtg caatctacat aaggagcttc
     5821 ttcgaggttg ttttgaggaa tataactcaa cagtttacga atcagctcga aaccttcttc
     5881 ttctgtttta gcggtgaaat gagtcacacc tgatttagtg gagtgaacgc ttgcgccacc
     5941 gaggttttcc tggctaacgt cttcacctgt tacggtcttc acaacttttg gtccggtaag
     6001 gaacatataa gaagtacctt ccatcattag cgtgaagtcg gtcagagccg gagaataaac
     6061 agcaccgccg gcacaaggac cgaagatacc tgaaatctgt gggataacac cggaagcaag
     6121 gatattgcgt tggaagattt ctgcataacc tgccaaagcg ttgatacctt cctgaatacg
     6181 tgcaccaccc gagtcgttga taccgataca gggagcgccc atcttcatgg cttgatccat
     6241 gattttacaa attttcaatg acatcgtttc tgacagtgaa ccggcagaaa cagtgaagtc
     6301 ttgtgcgaac acatatacca gacgtccttc gatcgtaccg cagccggtta ctacaccgtc
     6361 tcccgggtaa tgttttttct ccatgccgaa gttcgtgcat ctgtgctcaa cgaacatgtc
     6421 catttcttcg aagctaccct cgtcaagcag catagccaga cgctcgcgtg ctgtgtattt
     6481 ccctttttcg tgttgcttcg caattgcttt ttcaccgcct ccgatgcgtg ctacggcacg
     6541 gcgttcaata agctctttaa ttttttcaag ttgattactc atgagttctt gttgtttttt
     6601 tagagtttat gattagtgtt cgcagagttc tgtcagcaca cccagtgttg atttcgggtg
     6661 aaggaaagcg atgttcagac cttcggcacc tttgcgggga gccttgtcaa tcagacggat
     6721 ttctttgctt tctgcttctg ccaaagcatt agctacgcca tcttctacgg caaatgctac
     6781 gtgatgaaca cctgcacctt tgttttcaat aaatttagca atggtgcttt cggggcaagt
     6841 cggctccaac aattcgattt ttgtttcacc tacctttaaa aaagcggttc ttactttttg
     6901 atcttctact gtttcgatgt tgtaacattt cagacccaat acgttttcgt agtaaggaag
     6961 ggcttcttcg atgcttttta cagcaatgcc cagatgctca atgtgtgaaa tcttcataac
     7021 tatatttttt tatatggttt aattatgtgc ttatatggca taaaacagca caaagaaaga
     7081 catttcttgt ctaataaaga aatatttctg catttaatta ttggggaata aagcataaaa
     7141 aatgctccgg atgggtgaca aagacgggtt ttgtaatctt gagattacat ttagacataa
     7201 aacttgacca gaagattatt cagccatggc cagctgatac ggaaccaacg gcgggtactg
     7261 ctttgtttgc ctccgaaacg gagtacgaaa tcacgataac catgcttgcg gaagggaagt
     7321 cctacatcca tgaactccat gtgacggaat ccccgttcat gggcatcttc aagtgctttc
     7381 catactgcca gtatgccggg tgactgcagt gcatacgtct ttcgcattcc tcctgaaaac
     7441 cagataaaag cattttcgcc ggaatagatg cagacggagc cgccgataat cttttccttg
     7501 tattttacga tgaatatttt tgcctgtttt cctctgataa gcatgctgtt catgtggcgg
     7561 aaaaagtcat tggcagggaa atatctccgt attcgtgaag aataaacttt gtgcagcatc
     7621 cgcgagaatt ccttaatctc ttccaccgta tgggcttcta ctactttggc tccgtttttg
     7681 agtcctttcc ggatctgacg gatacgtgac gggctgaaac ggtcttccgc tttctgcgta
     7741 ctatgcagag agttacggac acgcagccag ttgaccggaa aaaagtcgtt ctttcggaag
     7801 aaacggtaac cgaacatgga attatccaga ttgcggaatt caataagaat gcaggtgcgt
     7861 gatgcttctt gtgtgagatg ctccagcatt tcaccgaaaa tttcttcctc cttctcttta
     7921 cttgccggta gagaagtgtc cagaaattca cctgcaccat ataccacaca ttgtttgaca
     7981 agagaggagg gaagccactt tttggtcttg cgtatggcgg caagcaggcg tgctacaggt
     8041 ctgccttctt ctgttgccac tatcagtagc ggggtatatc ccggagtcga ttcatagatc
     8101 tgaaacaact ccttggaatg aaaagtattg gttcccggta aatcaggaat gtcttttccg
     8161 cgataatatg ttgttagttt aagtggcatc caaatacaaa tttacacttt ttattcttca
     8221 ttcaacaata aaaaagagaa tttgttggct tagcctaaaa tttgtctttt tatcctttgc
     8281 atatatttga ggaaaaaaag gcttggaaaa gcgaattttt gtattattgt cgtcctttgt
     8341 gagtacagaa gtaaaatgga aacgtctatg taaaagatta tgctaattgt attttactaa
     8401 acaaaggaaa attaatatta actttaaatt aaaacgaatg agagagaatg catttgttga
     8461 agtgtggaag acacagcata gacgcgtttc catgatttta gggctgactt tattgtgtgc
     8521 cccttctgcc atatctgttt atgcagaaaa tggtgtgaat gatattactg tgcaagccgt
     8581 catgcagaca aagacagtga aaggaactgt tttagatgaa aatggagaac cgttgatcgg
     8641 tgtttctatt gtggtgaaag gtacaagtac aggtacgata actgattttg acggtaagtt
     8701 ctccattaat cttccggccg gaagtaaaga actggttgtt tcttatatcg gatataaaga
     8761 acaggctatt attgtgagcg gaaatgcccc gctgaatata aagatggttc cggatacaca
     8821 ggctttggat gaggtagtgg tcatcggtta cggtacggta aagaaacgtg atttgacagg
     8881 tgcggttgct tctgtgaaat cagaggatat caccatgaat ccgggcgtga atccgatgga
     8941 tgcgctgcaa ggtaaaattg caggtctgga tatcactaat tcttcaggtc aggcaggttc
     9001 gtcaccgaca gttcagttgc gtggtacccg ctctttgcag ttggatgagg atggtaatat
     9061 ttcttccgat gcatttaagc cgacttatat tatcgatggt atgccgggtg atattgctac
     9121 cttgaatccc aatgatattg aatctatcga agtactgaaa gatgcatctt ctacggctat
     9181 ctacggttca agtggtgcga atggtgttat tatcgtgact acgaaaggat ccaagagtgg
     9241 aaaaccggtc atcaatttca atgcttatgc cggaacgact ttaggagcta aagttcctaa
     9301 gatgcgtacg ggtgactcat acattaatta tataaaagat tcttataagc ctgtcggtac
     9361 tactaatgag gaggaaattt tcggtgaaag atacgatgcc atcaaaaaca accaatgggt
     9421 aaactgggga gatgaagtat tacactcagg tttgaagcag aattatagta tttccgttgc
     9481 cggaggtact gagaagacga aagcctattt ctcgttgaac tatactgatg agaagagtat
     9541 gtatgagaat gatgactata aagtgtactc tacccgtgtc cgtatagatc aggaaatcaa
     9601 taaatggatg aatgccggta ttaatgttca ggcatctttc tccaacaaga attcacgtaa
     9661 tgccgttttg gaaagagcat tgtttgccac cccgttaggt actccttata atgaagacgg
     9721 ctctatcacg gaattcccga ttccaggttc atcatcagac ccgaatccgt tagcagacga
     9781 acaggatgga gtatataaga ataatactaa agcaggaagg gcttatgttg acgcttatct
     9841 ggaatggaaa ccggtaaaag gattgtctgt caagtcacag cttggaggca gttattctca
     9901 atctcgtgcc ggtaaattta tgggagaagg ctcttataat gtgttgaaag gcagtacggt
     9961 ggcatatggc gaagctacca ataagacagg atataattac aaatgggaaa acatagtaac
    10021 ttatcacaat acatttaata aggatcatga cctgacggtt acaggggtta cttcctggaa
    10081 ttacaatcag agtgaagaat attatgtcta tggtgaaaac ccggcgacca atgatatgtt
    10141 gtggtatgca ttgcagaatg ctgataataa gaaactgaac agcaaatatc tgatgtcgaa
    10201 agggatgggc tttatcggtc gtgtcaacta ctcatacaaa ggtaaatacc tgttctctgc
    10261 ttccagtcgt tatgaagcgg attcccgttt gtcgaaagac aatagatgga atttattccc
    10321 ggcagtttct gtaggctgga gaatctcgga tgaagcattt atggctggta caaaaagctg
    10381 gttggataac ttgaaactgc gtgtaggcta tggtgttgcc ggaactactg ccggtattgc
    10441 tgaatacagt tctatggcat ctttggaaaa tgtgacaact tctttgggag gaatgactgt
    10501 tccgtcagcc aagtttacgg agtatatcac taaccgtaat ctgacatggg aaaagactca
    10561 tgacttgaat attggtattg acgccagctt cctcaataat cgtattgatc tgacggtgga
    10621 tttgtatcgg acaaaaacaa cggatgtaat tctttctcag gcattgccga catctattat
    10681 gggtaattac acaggtagca ctacttataa aatgaacaag aatgctgctg aaacagaaaa
    10741 tcgcggtatt gaacttgctc ttaatactcg taatattgtg aagaaagatt ttacttggag
    10801 ctcaacagtg acatttaccg ccaacaaaga aaaaattaaa tctttgatcg aagggcagga
    10861 tatgatgttc aatgcaaaaa agggtgatat ggtgttcaaa gtcggcgaag gagtcggttc
    10921 tttctataga tataaagtgt tgggtatctg gcaatatagc gaaaaggaaa ctgctgcttt
    10981 gttcggatgc gaaccgggcg atattaagct ggatttacct agtgtgaaga aggacggaaa
    11041 tggttattat tatatgaatc ctgaaggaga gcgcgttgat attacggcag aaaatcctta
    11101 tggtgtacgt gcggattatg atcgtcaggt aataggtcgt aatactccgg actggacatt
    11161 gggctttaag aataatttca gatacaaaga ttttgatttg tctgtcttcc tttatgcacg
    11221 ttgggggcaa atgatgaact atggtagtgt gataggtaaa tattcgccta acccggatta
    11281 caatgttcct acttatttta cttactatga caagacgatc gaagcagatc aggatgtctt
    11341 gttctatgct atcgataaat ccaaggatag aagtgcttat gaaggatatg attcgatgta
    11401 ttatgtggat ggatcattct ttaaacttaa aaacgtaaca ttgggttata cgttacccgg
    11461 taaacttaca aaacgttttg gtatcagtaa tctgagagtt tatgcgacaa tgaccaacct
    11521 gtttacttat tcgccaaaca aatatgtgaa gaattacgat ccggaaatga acggaagcat
    11581 caacttccca ttgtctcgtg attgcatatt tggtcttaat ttaactttct aaaaaatagc
    11641 aatatgaaaa agatatatag tttagttcta cttgttgccg gtgttttttc ttggggctct
    11701 tgcagtcttg atgaagtgaa ccccaacaac tcgggtcagt tctccgatgg ttcttataca
    11761 ttggaaactt ataaggcatt caccaactcg tgctatacag ccttgatcaa caacatctat
    11821 cagagtagtg actatctggt ttgtacggaa gcgggtactg atatttggga agaacctaaa
    11881 tcgggctcca gctatcagcg ttatcatagt tataacggta tgaaaaccga tgatagctat
    11941 tattataaag tgtggcaata ttcttatctg tgtatcaaca gctgtaatat tgtgattgac
    12001 ggagctgaga atgtgacagg ggatgagaat gaaatcaatg aatgtgtggc acaggccaga
    12061 tgtctgcgtg cttactatta tatgaatctg gtggagcagt ttggaaatgt cgatttgcag
    12121 ttgaaggctg ccgatagcga gaatatttct tttgatgctc accgttctac cgttcccgaa
    12181 atttatgctg ccattatcga agacctgaag tttgccgtag agaatctgcc cgtaagtttc
    12241 agtgattact atagccgcgt tacaaagaaa tcggcgatgg gattattggc acgtgcatat
    12301 attaatggtg ccggttatga tctgaaagat accgatggtg tcagctttct ggaaaaagcc
    12361 tatgatacgg cgacaaccat gattaataat aaagcgattt atgagtggta tatgcatcct
    12421 gcttttgccg atgtattcaa cgaaaataat aatcgtaaca atgaagaagc tctgttcatt
    12481 gctgcgggtg ccgaaagaaa ttcggacgct tacaccaatg gtaactactc acaaagtgaa
    12541 atgttccgtc acttcttacc ttcgttggga acatatacgg acctaggttt ggtagacaag
    12601 acttcaaact tcgtttacgg tcgtccgaac agtaatatct tcctgccatc caaatatctg
    12661 atggactgtt ttgctgctga tatgaacgac tctcgttttc gttattcatt tatctcagct
    12721 tactcgtctt attctatacc ggcatggggg gcgacttatg aatatggagg ttcagcgtgt
    12781 gccaaagaaa tcacaagcac acttgctact aaatttggta ttcccgcatc taatataggt
    12841 aagaaagttt atcctcattt taacttggaa tccaatagta cagccgatgc taattactgc
    12901 cagctggcta tctggaatgc agatggaaca gcgaagacta ctcaggataa aacagatggt
    12961 aatattcttc atcctgctat gcctttagat ccggcagaag ctcatcaata tgccgtttat
    13021 tgttctttga agacgctgac agaagaggaa aaagctcaat atccggggtt ggttcttaat
    13081 gttttcgatc tttacgatga gaatggaaca gccagggcta cctatgacaa gcctagtgct
    13141 gccagtgctt tgtggttatc tatttatccg gctctttcta aattcaatat gccgggtaat
    13201 aagtttgtcg gcagagacgt tcagagaaaa actgtggatg tgatgatcat gcgtatggcg
    13261 gaagtttacc tgattgctgc tgaagcatcg gtacgcttga acaagggaga tgctgccaaa
    13321 tatattaatg tactccgtac gcgtgccggt gccggtacgg tcagtgagtc gcaagtggat
    13381 ctgaattatg ttttcgatga atatgcccgt gaactttgtg gcgaatgtgg ccgctggtat
    13441 ttgctgaaac gtaatgctgc ttttgagact cgtttggctg cttataataa gcgtgctgcc
    13501 gagcacttta agaaagaatt ctatttgcgt cctattccta cgaaatatct ggatgcgatc
    13561 aataatccgg cagaattcgg acaaaatgcc ggttattaat cagttaatta ataatcaagc
    13621 ataattaata ggagccgggc aggagatttc tcttgtccgg ttctttgttt ccatgcctgt
    13681 ctctctgcca tataagttaa aaagggattt ccggcatatt ttcatggttt cctgatacac
    13741 acttttgtta ttttctttat ttttgtgtgt ccaaacaaaa tagcgctatg atagaagaaa
    13801 tgcttgctta taacagagag ttcgttaaga acgagggata taaagaatat ataacgaata
    13861 agtatcccga taaaaagatt gctatcttat cctgtatgga tacacgtctg acagctttac
    13921 ttccggccgc actaggcatt aagaacggag acgttaaaat gatcaagaat gcaggaggcg
    13981 tcatttccca tcctttcggt agtgtgattc gcagtctgct tgtcgctatc ttcgagttag
    14041 gtgtggagga aataatggtg attgcccatt ctgattgtgg agcctgccat atgcacagtg
    14101 aagaaatgct tgagaagatg aaggcacggg gtattaatgc cgattatatt catatgatga
    14161 gtttttgtgg agtcgatttt cattcttggc tagatggctt tgaagatacg gagaagtcgg
    14221 taaggggaac ggtcgatttt atagttcatc atcctttgat tccgtcggac gtgaaagtgc
    14281 acgggtttat catagactcc actactggag aactgacgcg aattgtatag gaaatcgccc
    14341 tttctgccta tcaggaactg cataaaacat ggtgtcacta tcgcaacagg atagtgtcac
    14401 tatcactgtc tcatggtgtc actatgtcat tgggataccg acactatccc aaatgaaaaa
    14461 aataaggcag ctttttatcg gctgccttta tctttctgcg gttatatact ttctttgact
    14521 catgcactcg tttgtaacaa acggggtgtc cgtgctcttt gatttctgcc tcacggctgg
    14581 ctttacgatt cgctttgatg taatcgtctt gtgtaattcg ttttttcata atgaatcttg
    14641 agttcaactt ataaatgcaa ctttttgggt gcggataata agcaataa
//
