LOCUS       gnlProkkaPHFIFHDC_68   11768 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PHFIFHDC_68.
ACCESSION   gnlProkkaPHFIFHDC_68
VERSION     gnlProkkaPHFIFHDC_68
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 18:00:51
            Original ID  :: gnl|Prokka|PHFIFHDC_68
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 3775
            Orig. end    :: 15543
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11768
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[5000:9314]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9314
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..11768
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11768
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(275..1288)
                     /locus_tag="ctg68_5"
                     /transl_table=11
                     /translation="MSFYIFIFVVLLYFSFRKYNKYIYWGTILLLSLIAGLRSETIGVD
                     THAYKDIFIWISNEVLYPIEPAWYFLNKLIAWVGGSFNFLLWITALLTLIPIGVVSLRC
                     SSNPQMSLFFYYGLYAYINSFNGMRQFVAISFVLLAYSYITQKKNFFLYLLIAFIFHYS
                     AIFSFIAILVDKVSLTKRRVIGGIFSSFFVGMFFNDSMFLVLAGPYAGYLESSEGYRDN
                     FLLAAIMAILMSCLYMCTFFTLRREYKQNLWTKMFFVGIIILNITMRLELGARIILYFT
                     LCQIIFYPMYFRHNIVKNKRMVVLSILLYTSLVFMKILILGNQGEYSVYPYKTILW"
     CDS             complement(1358..2893)
                     /locus_tag="ctg68_6"
                     /transl_table=11
                     /translation="MVESRSKKGIANIKCSLFFYIVNLFLNIISRKVFIDYLGIEVLGL
                     NTTVTNLLSFLNLAELGIGNAIAFTLYKPLFLKDFQVIREIVSVQAWLYRRIAYFISIG
                     ALGLMLLFPVIFKKIDLPLWYAYATFIVLLIASLLSYFVNYKQILLSADQKEYKITLCV
                     QGIKSLKTITQVVVILYLINGYVYWLTLELVGVLVSALLLNKIVNKEYPWLFVKVSDGK
                     KLRNKYPEIIVKTKQFFFHRISSFVLNQTSPLIIYAFASLTMVAIYGNYMLIVFGGIAL
                     VNAFFNGFNAGVGNLVAEGDKKKIKSFFWEITSFRIWIAAIICVCFFKLCHPFISLWVG
                     KEYVLDEMTFIVLTIYVFISLTRVNEAFLFAYGLYQDIWAPIIEAILNLGLSVLLGFIW
                     GLTGIISGVVISLVVIVCIWKPYFLFKMGFKDNILEYVSRYIKYYMMIALSFILSHLIL
                     NTMFIDFQSSYWKLFEYACTVGSCYAILSFLFFYLFDNGMRQFTRRLLNIFLK"
     CDS             complement(2895..3653)
                     /locus_tag="ctg68_7"
                     /transl_table=11
                     /translation="MLQIMKLTTYVLNLLKDKERKEYMQYVLSDYPNLDIQYVNAINGK
                     NLSLDEILNQFDNNKAYKRYGRECDLGEIGCSLSHRLAFDLLMNSESNYALILEDDIVI
                     GDGFSSVLEKLLPLIDIDAPCVILLSGGVSYYKKRYYNTLCLGVVYMGDYAHSYLINKA
                     AAKLILDDKKAYIFADDWDYIRNRGVNVLVILPHLVDQRRDGSFVSNVWQDNHHIVKVK
                     LSLIRLCNYILSRIIDKILKRMGNYENKTL"
     CDS             complement(3638..4459)
                     /locus_tag="ctg68_8"
                     /transl_table=11
                     /translation="MKDKTCHIITDDNIKEIELSILKYIDLQCKKYNLRYYLGYGTLLG
                     AVRHQGFIPWDDDIDIWMPREDYDKFISLENSLENSKFKILSPLNNSDYYYGFAKLVSR
                     NTELQEIGFLPIKDYGVYVDIFPLDNIATEHPFLHFIAKYIIMARIASCNIKPWLNLTH
                     KKKAILFRFIGIIGTLLGFRRTAKLTDKIAKIDKGKTNKRVGVFVESIGEHNIFATEYF
                     ASTIQLKFEGIYFNAPKEYRKCLTQLYGDYMQLPPENRRISGHSFKACYRL"
     CDS             complement(4528..5004)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156:Chloramphenicol acetyltransferase (Score: 70.3;
                     E-value: 2.9e-21)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg68_9"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYSNIY
                     LGKNAEIRSGCYLIARDKIIIGENSTLAYGTTILTTADPNGPYNALAILYPYKKAPVVI
                     GDNVWIGANVTILPGITIGDYVVVAAGSVVTKDVPSGVLVAGVPAVVKKQLLME"
     CDS             complement(5001..6122)
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg68_10_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg68_10"
                     /sec_met_domain="Aminotran_5 (E-value: 1.8e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        complement(5025..6032)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg68_10_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg68_10_Aminotran_5.1"
                     /locus_tag="ctg68_10"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             complement(6132..7256)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg68_11"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.3e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.1e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             complement(7273..8574)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 207.4;
                     E-value: 4.4e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg68_12"
                     /sec_met_domain="CTP_transf_like (E-value: 2.3e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 6.1e-121, bitscore:
                     392.9, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 2.9e-63, bitscore:
                     203.5, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKEGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKTILENERALEVRELCMPIKEILELIPGTK"
     CDS             complement(8595..9314)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.8; E-value:
                     3.3e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg68_13"
                     /sec_met_domain="NTP_transf_3 (E-value: 6.8e-17, bitscore:
                     52.2, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CGIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             complement(9378..10526)
                     /locus_tag="ctg68_14"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVLFGKSLLASLRKELKNKEIEQDK"
     CDS             complement(10537..11766)
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 71.3;
                     E-value: 9.5e-22)"
                     /gene_kind="transport"
                     /locus_tag="ctg68_15"
                     /transl_table=11
                     /translation="MRGAVYRPGIYQLSGKLNTIRELVHEAQGLTGDAFLNRAVLYRQR
                     EDLTSEVVQIDIKSIMDGTSPNLALMKNDILYIPSIHDLEDRGNVTVHGEVAQPDSYPY
                     ADNMTLEDLIIQAGGLKEAASTVRIDVSRRIKNPRSTADNDTIGQMYTFSLKDGFVIDG
                     QPGFILEPYDQVYVRRSPGYQAQQNVAIEGEILFGGNYAMTSREERLSDLVNKAGGPTN
                     YAYLRGAKLTRVANASEKKRMGDVIRLMSRQLGEAMIDSLGIRVEDTFTVGIDLEKALS
                     NPKSNADLVLREGDVISIPKNTNTVTINGAVMVPNTVSYMKGKNVDYYLNQAGGYSDNA
                     RKSKKFIVYMNGQVTKVKGSGKKQIEPGCEIIVPGKAKKKGNIANILGYATSFSSLGMM
                     IASIANLIKK"
ORIGIN
        1 ggttctacta tatcatcact atctacaaag caaatatatt cccccctgca tatagataaa
       61 gccttatttc ttgctgctga cactcctgaa ttaagctgag aaactacttt atatcgatta
      121 tccgacatta catattgatt cagaaattcc attgtattat cagtactacc atcattaaca
      181 caaattgctt cccattcaga atatgtttga gctaaaatag aatttaaaca ttcagaaata
      241 tattttcccg aattgtaaca aggaataata atgcttacca taatattgtt ttataaggat
      301 agacagaata ttctccttga ttacccaaaa ttaatatttt cataaaaacc aacgaagtat
      361 acaataaaat actcaaaaca accattcttt tatttttgac aatattatga cggaaataca
      421 ttgggtaaaa tataatttgg cataatgtga aatacaaaat aatacgagct cctaattcta
      481 accgcatagt tatattcaat ataataatgc caacaaaaaa catttttgtc cacaaatttt
      541 gtttatattc tcttcgtaaa gtaaaaaacg tacacatata taaacaactc atcaaaattg
      601 ccattatagc agccaataaa aaattatccc tatatccctc agaagattct aaataacctg
      661 cataaggacc agccaaaact agaaacatag aatcattaaa aaacatacct acaaaaaaac
      721 tagaaaaaat accaccaatt acacgtcgtt tagttaatga taccttatct accaaaatag
      781 caatgaaaga aaaaatcgct gaataatgga atatgaatgc aattagtaaa tacaaaaaaa
      841 aattcttctt ttgtgtgata taagaataag ctaataatac aaatgaaata gcaacaaact
      901 gtctcattcc attaaatgaa ttaatatatg catataatcc atagtaaaaa aacaaactca
      961 tctgaggatt actgctacat cgtaaactaa ctacacctat tggtattaaa gtcaatagtg
     1021 cagttatcca caacaagaaa ttaaaacttc cccccaccca agcaatcaat ttatttaaaa
     1081 aataccatgc aggttctatc ggatataata cttcatttga tatccatata aatatatctt
     1141 tataagcgtg agtatcaact cctatcgttt cggacctcaa ccctgctatc aatgaaagta
     1201 ataaaatagt tccccaataa atatatttat tatatttcct aaaagagaaa tacagcaaaa
     1261 caacaaaaat aaatatataa aaactcattt tttataatac aagacaaaat ctatttcagc
     1321 taaaaactaa atataacaac tacaccttat cactaaatta ttttagaaat atatttaata
     1381 aacgtctagt aaattgtctc atcccattat caaataaata aaaaaagaga aaactcaata
     1441 tagcataaca gcttccaaca gtacaagcat attcaaaaag cttccaatat gaactttgga
     1501 agtctataaa cattgtatta agaattaaat gtgacaaaat aaaagataaa gcaatcatca
     1561 tataatattt tatatatcta gagacatatt ctaatatatt atctttgaaa cccattttaa
     1621 ataaaaaata tggtttccat atacatacaa tgacaactaa actaataaca accccagata
     1681 ttattcctgt tagtccccaa ataaatccca ataaaaccga aagtcccaag tttaatatag
     1741 cttcaattat aggagcccat atatcctgat ataatccata agcaaataga aaagcttcat
     1801 ttactcttgt taatgatata aaaacataaa tagttaacac tataaaggtc atttcatcca
     1861 aaacatattc ctttcccacc cacaatgaaa taaaaggatg acacaactta aaaaaacaga
     1921 cacaaatgat ggctgctatc catatccgaa aagaagttat ttcccaaaaa aaagatttta
     1981 tttttttctt atctccttca gcaacaagat ttcccactcc agcattgaaa ccattaaaaa
     2041 aagcatttac cagagctatt ccaccaaaaa ctatcaacat ataatttcca tagattgcta
     2101 ccattgtaag actagcaaag gcatagatta tcaatggact agtttgattt aaaacaaatg
     2161 atgagatgcg atgaaaaaaa aactgttttg tctttactat tatttctgga tatttattac
     2221 gtaatttttt tccatcagag acctttacaa acaaccaagg atattctttg tttacaattt
     2281 tatttaatag caaagctgaa accaataccc ccacaagttc aagagttaac caatacacat
     2341 acccatttat tagatataat ataacaacca cttgtgttat ggtttttaat gattttattc
     2401 cctgtacaca aagtgttatt ttgtattctt tttgatctgc acttagaagt atctgtttat
     2461 aattcacaaa atagctcaac aaagaagcta tcaataaaac aataaatgta gcataagcat
     2521 accacaaagg taaatctatt tttttaaaaa ttacaggaaa aagcaacatt agtcctaaag
     2581 cacctataga tataaaatat gcaattcgtc gataaagcca agcttgaaca gacactatct
     2641 cccttataac ttgaaaatct ttcaaaaata aaggtttata taaagtaaat gcaattgcgt
     2701 taccaattcc caattctgcc aaatttagaa aactaagcag attagtaact gttgtgttaa
     2761 gtcctagtac ttctattcct aaataatcga taaagacctt tctagatata atattaagaa
     2821 ataagtttac gatataaaaa aacaaagaac attttatatt tgctatacct tttttagaac
     2881 gtgattcaac catactacag tgtcttattc tcataatttc ccattcgctt caatatttta
     2941 tctattatcc ttgaaagaat atagttacac aacctaatca atgataattt caccttcaca
     3001 atatggtgat tatcttgcca aacattactt acaaaacttc catctctacg ttgatcaact
     3061 aaatgaggta aaataactag tacatttact cctctattac gtatataatc ccaatcatca
     3121 gcaaatatat acgctttttt atcatccaat attaatttag cagcagcctt atttattaaa
     3181 taactatgcg cataatctcc catataaact acacccaaac acaaagtatt ataatatctt
     3241 tttttataat aagagacacc acctgacaat aaaataacac aaggagcatc gatatcaatc
     3301 aatggcaata atttttccaa tacgctacta aatccatccc caataacaat atcatcttct
     3361 aaaattaaag catagttact ctccgaattc attaataaat caaacgccaa tcgatgactc
     3421 aaactgcacc caatttctcc taaatcacat tctcttccat agcgtttgta tgctttatta
     3481 ttatcaaatt gattcaatat ctcatccaga ctaagatttt ttccatttat tgcattaaca
     3541 tattgaatat ctagattagg ataatcgctc aatacatatt gcatatattc ttttcgttct
     3601 ttatctttca ataaattaag aacatatgtt gttagtttca taatctgtaa catgctttaa
     3661 atgaatgacc agaaatgcgt ctattttcgg gaggtagttg catataatct ccataaagct
     3721 gagtcaaaca ttttcgatat tcctttggag cattaaaata tattccctca aatttcaact
     3781 gtattgtaga agcaaaatat tctgttgcaa atatattatg ctctcctatg ctttcaacaa
     3841 agacccccac ccttttattc gttttaccct tatctatttt agctatctta tccgttaatt
     3901 ttgctgttct tcgaaatcct aacaatgtcc caattattcc tataaagcga aataaaatag
     3961 cttttttctt atgcgtcaga tttaaccaag gttttatatt acaagacgca atccttgcca
     4021 ttattatata tttagctatg aaatgtaaaa acggatgctc cgttgcaata ttatccaaag
     4081 gaaaaatatc cacatataca ccataatcct taataggaag aaatcctatt tcctgaagtt
     4141 ctgtatttct tgatactagt ttagcaaatc cataataata atctgaattg ttcaaaggag
     4201 ataaaatctt aaactttgag ttttccaatg aattttctaa acttataaat ttgtcataat
     4261 cctcccgtgg catccagata tcaatgtcgt catcccaagg aatgaaacct tgatgacgca
     4321 ctgctcccaa taaagtacca tatcccaaat aataccttag attgtacttt ttacattgta
     4381 aatcaatata tttcaatata gataattcta tttcttttat attatcatct gttattatat
     4441 gacaagtttt atctttcatt attgaggcat taaattatac ttcttatgta atgatattgt
     4501 ctgacaataa gaataaaaca attattctta ttccatcaaa agctgttttt tcacaacagc
     4561 tggtacacca gcaaccaata cccctgaagg tacatctttt gttacaacag atccagctgc
     4621 tactacaacg taatcaccaa tagttattcc aggaaggatg gtaacattag ccccaatcca
     4681 aacattatct cctataacta ccggtgcctt tttataagga taaagaattg ctaatgcatt
     4741 atacggtcca ttaggatcag cagttgtcaa tatagtcgtt ccataggcga gtgttgagtt
     4801 ttctccaata atgattttat cacgagcaat cagataacag cctgaacgta tttcagcatt
     4861 tttacccaaa tagatattgc tatatttgcc tactaagcga aagctacgaa taggcactcc
     4921 agaaataaca ctttccggat ggaagtgtat accacgaagg gaaaaataaa aatgacgaat
     4981 cttcaataat atttctgcaa tcatgacatc ggtaatgtga cgttataatg atttaatgca
     5041 gcttttagta ctttaaagaa gttctcaata tcatctactt ctatctctcc taaagcacag
     5101 attctaaaag tatcctcagt tgatatctta cctggataaa tcgtaaatcc acgctcataa
     5161 caataatcat gtattttctc aaaatcccag ttgggatctt ctgggtattg aactgagaca
     5221 accagtcctg actgccattc acgctttatt acacttttaa gaccaatttc atttatacct
     5281 gaatgaatag cctcaaaaac tcttttgtga cgggcaaact tagcttcttc gcccacttca
     5341 aaatattcat ttaatgcctg acgagtggcg taaatagttt gtaccggtgg agtaaaatgc
     5401 atttcacctg ttctctcaaa attctcatac tgcaaataaa gattacaata gtaagaacgc
     5461 ttgggatatt tttttgaaaa cttaatctgt tcctcattgc ctataataaa agaaagacct
     5521 gtcatcgctt gaagtccttt ttgagcagat gccatacaaa aatccacatt atctttctct
     5581 atatcaaaag gaatcatgcc caaagaagaa gtagtatcga cgacaaattt agcctgatat
     5641 ttatgagcta tagcgcccat ctcgcgaata gggttcagaa ttcctgtacc cgtctcgtga
     5701 tgagtagtat aaaccatagc tatatcagga ttttcttgca acacattttc caccaccgat
     5761 aaatcaggac gttcataaac ggaaaattcc aaattaatat gaggcaaacc ataatattga
     5821 cacacttcta cagcacgggt actatatgcc ccattattca ctataagcac ccttttgtct
     5881 tcaggaagaa gagaatttag acatatatca atattgatgg ttcctgagcc acaaaataat
     5941 acagcggtat gtttttccaa attcccatga gcaactctga ccaaatcgtc ccgaagttgt
     6001 ttcatcatac ctgcgaattc tttctcgcga ggacaaatat ccggaacaac ttgtgccatt
     6061 tttacactgt cagtagtagt ggcaggccca ggatttaata atatttttct ttctattttc
     6121 atcgaatata tttattttaa aaaatccata aaatgctcct tattctctat aggagtagtc
     6181 gtgggacgtc ccaaattctc ccgagaatct attttaacct ttatttccaa caaaacagga
     6241 ccacataact ttggaagctg cttcattgct tcttcaattt caacttttgt acaaacagta
     6301 taagtatgct tatatccgct cccccggaca atagccggaa tatctaaact aaatcctaaa
     6361 gtaggctgtc ctcctacaga ctcgtgagca ccattgttaa acaaaatatg ataatagttt
     6421 ttaggagata aatcgccaat gttactaatt gcccctaaat gcataataaa tgctccatca
     6481 ccatccaagc aataaacagg tctatcttgc tttgctatag caatacccaa agagattgat
     6541 gaactatgtc ccatagagcc taccgtgaga aaatcatgtt catgaccttg ctctttcatt
     6601 tctcgatatt caaataactc acgagaaagc ttgccagtag tagaaacgac cactgaattt
     6661 tcaggcagat aatccacaac tatttgcaaa gcatcctcac gagataaagg ataattacat
     6721 ccaaactctt tttgaagttt atatttgcca aaaacatctt tccgaataat tattgcatga
     6781 ggaatattct tagtttttgc tgattgtatg atatcatgga gctgaataaa tgcatcattc
     6841 tcatttgaat caagaattat ataaggaatc cgcattgctt tcaacaaatc taaagttacc
     6901 tcaccctgtt ttttatgctg aggttcatct tttgttcccg gttcaccacg ccagccaatc
     6961 atcaaaagca ttggaaaact gtatacttgt tcatctgcaa gagacagcag aggattaaca
     7021 gtattaccca agccggaatt ttgcatataa accacaggaa ccttacctga tgccatataa
     7081 taacctgaag caattcctac agccgcacct tcattagcag ctatgatatg tttctcacgt
     7141 gaagtatggt ctgtgatata ggcacaaata ttttttagta atgagtctgg aactcctgta
     7201 aaaaaatcaa cgtcatgact cagaaacgtt tcataaactt tttctacgct taacataatg
     7261 atattcctct ttttatttag tacctggaat cagttccaat atttctttta tgggcataca
     7321 cagttcgcgc acctctaaag cacgttcatt ctctaatatt gtctttgcga cattcatcat
     7381 agcaggataa gcggcacgaa gcatatgatt agcataaata attatattca caccccaatc
     7441 acacaattca gactcataaa tatgatcata tgtagtaggc acaaccacga taggtacatg
     7501 agcatactgt tttcgaaacg ccaaacaaaa ttcttttata tcttcacccg acttattttt
     7561 gctatgtatc ataataccgt ccgctcccgc ttggacatat gcaaaagctc tctctaaagc
     7621 atcacttacc ggctttcccg ctataaggct ctcaatacga gcgataatca taaaatcatc
     7681 agtaatctga gatgcctttc cttctttgat cttattacag aaaccttcga ttgtatcttg
     7741 agtttgaata acatctgtac caaacaatga attctttttt aatccaactt tatcttcaat
     7801 tattatagct gaaattccat gacgttctaa agtgcgtact gtaaatacga aatgttcaat
     7861 tttaccacct gtatctccat caaaaataat aggtttagta gtacactcca gaatattatt
     7921 caaatcttgc aatcgggtag ttaaatcaac cgcctcaata tcaggtttac ctttactggt
     7981 tgaatccgta aggctactag accacattcc gtcaaatact tccctcttat ccccttttaa
     8041 tatttcctga ttttcaatta tcaagccaca tagtccatca tgagcttcca aaatacgaac
     8101 tacgggtttg gcatttatca aacgacgaag tgattttaaa cgtacatcag gggttgtacc
     8161 tatagcctta atatctttat ccaaagaaga tgaattaatt cccaaagtat atggaatttc
     8221 gataaccttt cctccctgtt cattcatcac ttcaaatacg cgcacacgtt cttcacgtaa
     8281 aggcccggtt ttccagtcgt caccatgaat tatatagtca ggtttaatgc gtttgagatt
     8341 ctcaacatag ctccattctt cttgaggaac aactttacat acgcctttaa tattctgaac
     8401 tacctctttt cgttgttcat aggtcagata aggaaggcgt ttatgctccg caatagcttt
     8461 atctgtaaga agaccaatta taacatcacc gtatttagta gcctcattaa taatgcggat
     8521 aagtcctgga tgcataatat ccgcagtcat cccaatataa actgtcttac tcataatttg
     8581 atatattatt ttaattaaca atacggaaca atatatttct ctgcatattc caaatctgat
     8641 atgtcatcga tttcatacca tttcagccct tctactttat gcacataaac aggagattga
     8701 gaacaagata ttcgtagtaa ttcatactca tatcccaaat tgggttgttc atcaacaata
     8761 ctcgcataat cagcacacat tattttgtaa aaggaaccgg atagtttatg gatgccgacc
     8821 aattcgcctt tagcgtttag tttattctta ttgacagaac atgaagaaag gcgaaaatta
     8881 tcatcatgtt ccacataata ctgatcttga aactttgtca ctggagttat tagcattgca
     8941 tctgccgcag gacactccaa taagctcatt attgcttgtt tctcaaaaat caaatctgac
     9001 tctaacaata aaaaatcatc attgcccaga atctcccgcg tattatataa agtatacata
     9061 ctatttgttt cagcataacg aggactaaaa caggtttcaa gcataggata gtctgtcttc
     9121 aattcttcat aaacttcttg tttatatcct gtaccgatta caattcgctc aatgccacat
     9181 gataacaaag tatcaataga acgaactatc attggaatac ctcccacttt gacgaaccct
     9241 ttaggtatca attctgtata ttggccaaaa cgggttccca tgcccgcagc cattatcata
     9301 gctgtacgta tcattcgttt aataatatag taagtgaatt taattgatgt aagaatgttg
     9361 taaacgacgt tttagcatca tttatcctgt tctatctcct tatttttcag ttcttttctc
     9421 aagctagcca gcagactttt gccaaaaagc acccacacga gagtaccaga tacggacagg
     9481 aacacaaata ataaaatata aattttgagt cccatacctg aaggtttcaa aggtacaacg
     9541 gcaggctcaa ctactgcaaa gactggcttt tcctcctgta ctttggctct ggatacctgc
     9601 aactgattag caacctgact atatatctga taagccaaac tcatgtcgtt ctgtaaacgc
     9661 tcctgctcag cacgtacact ttgaagaacc acattatcat gggcgtctac ataatccgca
     9721 tattttcttt gagcagcata atattcctgc tgacgttctt taaacaaccg ttccaaatac
     9781 gcacagtctt cttttacttt tgaagttcga tacccaataa tatattcctg taatttatga
     9841 acgacagaat ctgctataac cgcagtgatc tgcggatttt gtaaggtgac cgtaatgctc
     9901 gttatggcgg ttttcttatc aatggatgca ctaatcttct ttttaagaaa attaatcttc
     9961 tcatttactt ctttcgtcaa ttcgatagtt ccttgccgcc ctccactggc aggaaccgta
    10021 tcttctccga ataatgattt aactcctcct attactatgc ccggaaaacc tataagataa
    10081 tcccaccaag gagatgactc ttcatcgaga taagacccca aagtcatttt atcatccttt
    10141 ttagaaacgg agacttccat ttctaaaagt tccaataaaa aaggagttga agaaacaata
    10201 tctgctgaaa gagaagcgtt caaggcatct gtgctttccc ctattagagc cccatctccc
    10261 aaaaacgagg cagcaagtcc ggctaaacca ttacttccct tcgcattacc catttcagga
    10321 gaaagggtaa cctttactgt atattgcttg ggaatgctca atgccaccac tatagcaatt
    10381 attactccca ctccagcagc tttgcatagt actccacgaa cagtaataat cttataaaaa
    10441 atagccatca agtctatttc catttcatca tctttccttt tatccacttc agaaaacggt
    10501 tcttgataag attgcttttc aatcataata ggtcatttat ttctttatca aattagcaat
    10561 agaagcaatc atcattccca aagaactgaa ggaagtagca taacctaaaa tattagctat
    10621 gttccctttc ttcttagcct taccaggcac aataatctca catcccggct caatctgttt
    10681 cttaccacta cccttaacct tcgtcacctg accattcatg taaacaatga atttcttact
    10741 cttccttgca ttatcagaat aaccaccggc ctgattcagg taataatcca cattctttcc
    10801 cttcatataa gaaaccgtat tcggaaccat gacagcacca ttgatagtta cagtattagt
    10861 attcttaggt atggagatca catcaccttc acgtaagaca agatcggcat tacttttagg
    10921 attgctcaag gctttttcca aatctattcc aaccgtaaaa gtatcttcaa cacgaatacc
    10981 caaagagtca atcatggctt cgcccaattg cctgctcata aggcgaatta catcacccat
    11041 acgtttcttt tcactagcgt tagccacacg ggtcagtttc gcaccacgca gataggcata
    11101 attggtcgga ccgccggctt tattcactaa atcggaaaga cgttcctcac ggctggtcat
    11161 ggcgtaattt cctccgaaaa ggatttcacc ttcaatggct acattctgtt gtgcctgata
    11221 gcccggactg cgacggacat aaacctgatc ataaggctca aggataaaac cgggctgacc
    11281 atctattaca aaaccatcct ttaaagagaa ggtatacatc tgaccgatag tatcattatc
    11341 cgcggtacta cggggattct tgattcgtct cgacacatca atgcggacag tggaggcggc
    11401 ttctttcaag ccaccggcct gaatgatcag atcctcaagt gtcatgttat ccgcataagg
    11461 ataggaatca ggttgggcaa cctcaccgtg aactgtgaca ttaccccggt cttccaggtc
    11521 atggatactt ggaatgtaga ggatgtcatt cttcatcagg gcaaggtttg gggaagtgcc
    11581 gtccatgata gacttaatgt ctatctgaac aacttcactg gtcaggtctt cacgctggcg
    11641 atagaggacg gcacgattca ggaaagcgtc accggtcaga ccctgagctt catggacaag
    11701 ttcgcggatc gtgttcagtt taccgctgag ctggtagata ccgggacgat agacagcgcc
    11761 acggattt
//
