LOCUS       gnlProkkaEPOOHKKB_37   13614 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EPOOHKKB_37.
ACCESSION   gnlProkkaEPOOHKKB_37
VERSION     gnlProkkaEPOOHKKB_37
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 17:33:23
            Original ID  :: gnl|Prokka|EPOOHKKB_37
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 14340
            Orig. end    :: 27954
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13614
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10348]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10348
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13614
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13614
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             2055..3089
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg37_15"
                     /sec_met_domain="PF04055 (E-value: 2.1e-17, bitscore: 54.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKYPLLGMTLIELQSLVKRLGMPGFAAKQIASWLYDKKVTSIDE
                     MTNLSLKYRELLKQNYEVGAEAPVEEMRSVDGTVKYLYPVGENHFVESVYIPDDERATL
                     CISSQVGCKMNCKFCMTGKQGYSANLTAHQIINQIHSLPERDKLTNVVMMGMGEPLDNL
                     EEVLKALDILTGSYGYAWSPKRITVSTVGLRKGLRRFIEESDCHLAISLHSPVTAQRAE
                     LMPAEKAFSITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCRI
                     NLIRFHSIPGVALEGADMDTMTRFRDYLTTHGLFTTIRASRGEDIFAACGMLSTAKQEE
                     NNKS"
     CDS             3107..4144
                     /locus_tag="ctg37_16"
                     /transl_table=11
                     /translation="MKKYFFYLSMALVAFVVASCGLKGNHTSSGRPYELLVVVDAGVWD
                     RAAGRALHDVLDSDMPGLPQSEPSFRIMYTSPKDYDSTLKLIRNIVIVDIKDIYTKGTF
                     KYAKDVYASPQMILTIQAPNEEVFEKFVEENKQTIIDFFTRAEMNRQITLLEEKHNNFI
                     SNKVDSLFGCDIWIPSELNNSKTGEDFFWASTNTGSADRNFVMYSYPYTDKDTFTKEYF
                     VHKRDSVMKANIPGYKEGVYMSTDSLLTDVRPINVHNDYTMEARGLWRMKGDFMGGPFV
                     SHTRLDQKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPQEGQQSQIPLGVTKEA
                     EPTNK"
     CDS             4149..5243
                     /locus_tag="ctg37_17"
                     /transl_table=11
                     /translation="MEENKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDVQANFSIVNTASEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGDGNKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEIIIPAMKEMEEKGIICYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGLASEDSFRQAIYVAIDVFRNRQREKAARVN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             5367..6608
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 388.8; E-value:
                     6.1e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg37_18"
                     /transl_table=11
                     /translation="MTKAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPLPTQARLLRVLESGEFIKVGSSKVQKTDVRIVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFAADFAEKYRMPAIQLTEDAKKI
                     LLAYPWPGNVRQLKNITEQISIIETNREITAAILQTYLPAQNTQRLPALFGTRESKSFE
                     SEREILYSVLFDMRQEVAELKKMVHNMMAERAGQVGQMGQVVATPVVTTTHQPSVPAII
                     HAVQQPSVCPKEDDDDIQDTEEYVEETLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             6595..7122
                     /locus_tag="ctg37_19"
                     /transl_table=11
                     /translation="MNWIKKIARPLILVVLPAVIIACSVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPNQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSSQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             7127..7888
                     /locus_tag="ctg37_20"
                     /transl_table=11
                     /translation="MTSVNLQQWIQHPETLNRDTLYELRNQLARYPYFQSLRLLYLKNL
                     YILHDINFGAELRKAVLYIADRRKLFHLIEGERFAVESQKKGLPLSEVLKDEPTVDRTL
                     ALIDAFLSTAPEEVTSQTSFDYSMDYTAYLLEETPVVDEPAEAMPKLKGHELIDNFIEK
                     SETDPVVYLKPLKEEEKAKAASSAETNETGRTDETTETNTVEEEDDSCFTETLAKIYVK
                     QQRYSKALEIIKKLSLKYPKKNAXXXXEIDY"
     CDS             7950..8306
                     /locus_tag="ctg37_21"
                     /transl_table=11
                     /translation="MLMCFIVLIQNSKGGGLASGFSSSNAIMGVRKTTDFLEKATWGLA
                     IFMVVMSVATAYVVPSSSAAKDVLLEQAQKEQQTNPYNMPTGTAAPQTDATAPAESAPA
                     TEAPATETPAPAAE"
     CDS             8568..9956
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 91.3; E-value: 8.1e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg37_22"
                     /transl_table=11
                     /translation="MTEQLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AITTTFPEGAMLFGFKMQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGVFHTNIPAPILFCLVMLCVGTIAFFIYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMVIGSVMLIFVHTMFAL
                     PILNIWWFATVIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNSYCKGPVVDGAQTYDYTLPMAIFAMFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             10001..10348
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg37_23"
                     /sec_met_domain="PF05402 (E-value: 2.5e-17, bitscore: 53.8,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PqqD_RRE (E-value: 9.3e-10, bitscore:
                     29.0, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATKEKINLLEVIPCRNEHIKAEQEGETIVLSFPRFKRSWMSRYL
                     LPKGMSKDIHVRLEEHGTAVWNLIDGQRTVREIIEKLADHFQYEAGYESRVSTYLSQLQ
                     KDGFIKWIIIH"
     CDS             complement(10338..10625)
                     /locus_tag="ctg37_24"
                     /transl_table=11
                     /translation="MGGEGHMLDMIRRLKDGKEASRLRRERRNDKLGRLRRNNDPYLLP
                     DTTPEEMERIIKDSEKKKEKDNSYFVWGTLIIMGVLIGCAVLLWAIFFNG"
     CDS             complement(10647..11711)
                     /locus_tag="ctg37_25"
                     /transl_table=11
                     /translation="MKKLIIATGLLMATSAYAQTEVLTGVTRGKDYGVVYALPKTQIEI
                     EIKANKVNYKPGEFSKYADRYLRLTNVSAEPEEYWELNSVKVKPVGVPNSEATYFVKLK
                     DKTVAPLMELTEEGLIKSINVPYSSNNAKNAANNAVAPQRKANPRDFLTEEILMASSTA
                     KMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNLQEEAMTEMFSGVRNK
                     EEKTFTVRLTPDKEFDNEVAFRFSKKLGIVANNDLAGTPFYISLKDLKTVKIPQEDGKK
                     KKEMEGIAYNVPGQAMVTLTDGKKKLYEGEIPVTQFGIIEYLAPVLFNKNSTIKVYFDP
                     VTGGLLKVDREESK"
     CDS             complement(11785..13296)
                     /locus_tag="ctg37_26"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIEHEPIASIDLMERAAQALTKAITNRWNP
                     ETPVTIFAGPGNNGGDALAIARMMAEKGYKIEVYLFNTKGELSPDCQTNKELVEMMEEV
                     TFHEISTQFVPPTLTPEHLVIDGLFGSGLNKPLSGGFAAVVKYINASPAMVVSIDIPSG
                     LMGEENTFNVKSNIIRADVTFSLQLPKLAFLFAENTEFVGEWELLDIQLSEEGIEETET
                     NYEMLEIEEIRSLIKPRQQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPLCNNDILQTSAPEAMVEADVSETCFAVPTDTDDYQAVGIGPGLGRNEETEAALIEQ
                     LEHCQTPTVLDADALNILANHRHTLTHLPKGSILTPHPKELERLVGKCQDSYERLMKAC
                     ELAHTAKVHIILKGAYSAIITPEGKCYFNQTGNPGMATGGSGDVLTGVILALLAQGYPA
                     EDAAKIGTYIHGLAGDIAQKKQGMIGLIASDIVTCLPTAWRLVSE"
ORIGIN
        1 acgacgaaca gaccaatcag gtgcgcgacg aagtatggcg ttcctacgtt aataacaaac
       61 tggttgagaa agaagcaaaa gcattgggac tgacagtttc tgctgctgaa attcaggata
      121 tcctgaaagc aggcgtgcat ccgttgttgc aacagactcc tttccgcaac ccgcagaccg
      181 gtgctttcga taaggatatg ctcaataagt tcctggtaga ttacgctaaa atgaacgaat
      241 ctcagatgcc ggctcagtat gcagaacagt acaacaacat gtacaaatac tggtcattca
      301 tccagaagac attgattcag agccgcctgg cagaaaaata tcaggcattg gtagcaaaag
      361 cgcttctctc taacccggta gaagcacagg acgctttcga cgcaagagtg aatcaatatg
      421 atttgttgat ggctgccgtt ccttattctt ctatagtaga ttctacaatc gttgtgaaag
      481 aatcggaact gaaagacctt tataacaaga aaaaagaaca gttcaagcaa tatcaggaaa
      541 gccgtgatat caagtacatt gatgttcagg tgactgcaag tgcggaagac agagctgcta
      601 tccagcagga agtagacgaa gctactgcac agctggctac tacaacagat gactatactt
      661 cttttatccg ttctgtaggc tcggaagctc cttatgtaga cttgttctat aataaaacag
      721 ctttcccgtc agatgtagtt gcccgtctgg actctgcatc cgttggttct gtttatggtc
      781 cgtactataa tggtgccgac aatactatca attcattcaa agtggttgca aaaacagctg
      841 ctgccgactc aatcgagttc cgtcagattc aggtgtttgc agaagacgct ttgaagacaa
      901 aagccttggc ggacagtatc tatactgcta tcaaaggcgg tgctaacttc gcagatctgg
      961 ctaagaaata cggtcagacg ggtgagacta actggatgag ctctgcacag tatgaaggcg
     1021 cacagatcga tggtgacaat ctgaagttta tctctgctat caataataca ggcgtgaacg
     1081 aagtagtaaa tctgccgttg ggacaagcta atgtaatcct gcaagtgact aacaagaaag
     1141 ctgtgaagga taaatataaa gtagctgttg tgaaacgtga agttgaattc agcaaagaga
     1201 cttataatcg tgcttacaat gatttcagcc agttcatcgc tgccaatcct actgctgaaa
     1261 agatgatcgc taacgctgaa gaagccggat acaaactgct tgacagaaga gacttgtata
     1321 gctcagaaca cactatcggt ggtgtaagag gtactaaaga agcattgaga tgggcatttg
     1381 ccgctaaacc gggtgatgtt tccggtttgt atgaatgtgg cgaaagcgac catatggttg
     1441 cagtagctct ggttggtgtt actccggaag gatatcgtcc gctaaaagct gtacaggatc
     1501 agttgagagc tgaaatcgtt aaagataaga aagccgaaaa gatcatggct gacatgaagg
     1561 ctgccaatgc aacttctctc gaccagtaca aggctatgtc cggcgcagtc agcgattctt
     1621 tgaagctggt tacatttgcc gctcccgctt atgtttctgc attgcgcagc agcgaaccgt
     1681 tggtaggtgc ttatgcttct gtggctgaaa tgaacaaact gagcgctccg atcaaaggta
     1741 atgccggtgt atttgtgctt cagatgtatg gcaaagacaa actgagcgat actttcaacg
     1801 ctaaagatga agaagctaca ttggctaaca tgcacgcacg cttcgcaagc cgtctgatga
     1861 acgacctgta tctgaaagga aaagtgaagg atacacgtta cctgttcttc taagattagt
     1921 cgtaaaatcg ataactgcaa aaggtcgttc catgctttgg aacgaccttt tttgctaact
     1981 tttacatcct tgctatacgg aaatcgactt tatttcctta catttgcaaa tataaaccat
     2041 gaacagaaag aatgatgtct aaatatcccc tcttaggaat gacgcttata gagctgcagt
     2101 cactggtgaa acgtctggga atgccgggct ttgcagccaa acagattgca tcctggcttt
     2161 atgataagaa ggtgacttcg attgatgaaa tgactaactt gtcgttgaaa taccgggagt
     2221 tactgaagca gaactatgag gtaggagctg aagctccggt ggaggaaatg cgctctgtag
     2281 acggtacggt gaaatacctg taccctgtgg gcgagaatca ttttgtggag tcggtgtata
     2341 ttccggatga tgaacgggcg actttatgca tctcttcgca ggtaggctgc aaaatgaact
     2401 gcaagttctg tatgaccggg aaacaaggct actctgccaa cctgaccgcc catcagatta
     2461 tcaatcagat tcactccttg ccggaacggg acaaactgac gaatgtcgtc atgatgggaa
     2521 tgggcgaacc gctcgataat ctggaagagg tgttgaaggc attggacata ctgactggat
     2581 cctatggtta tgcatggagt ccgaagcgga ttaccgtttc aactgtcgga ttgcggaaag
     2641 gattgcggcg ctttatcgaa gaaagcgact gtcatcttgc catcagcctg cattctccgg
     2701 tgaccgccca gcgtgcggaa ctgatgccgg cggagaaagc cttttctatc acggaaatgg
     2761 tggaactgtt aaaaaactat gattttagca aacagcgtcg actttcgttt gagtatattg
     2821 tttttaaggg gcttaatgat tcgcaagttt atgccaagga gttactcaaa ctgcttcgcg
     2881 gactggattg ccggattaac ctgatccgtt tccattctat tccgggagta gcccttgaag
     2941 gagccgatat ggatacgatg acccgtttcc gtgactatct gaccacgcac gggcttttca
     3001 ctaccattcg tgcttcgcgg ggagaggata tttttgcggc atgcggtatg ctgtcgactg
     3061 cgaaacagga ggaaaataat aaaagttaat ataaaaatcg aacatcatga aaaagtactt
     3121 tttttattta agcatggctc tggtagcctt cgtagttgct tcttgtggat taaaggggaa
     3181 tcatacctct agcggtcgtc cgtatgaact gttggttgta gtagatgcgg gagtgtggga
     3241 ccgtgccgcc ggaagggcct tgcatgatgt gcttgattct gacatgccgg gactgcccca
     3301 gtcggaacct tctttccgga ttatgtatac ttcaccgaag gactatgatt ctacgctgaa
     3361 gttgatccgt aatattgtga tagtagatat aaaagatatt tataccaaag gtactttcaa
     3421 gtatgcgaaa gacgtttatg cttctccaca gatgatactg accattcagg ctccgaacga
     3481 agaagtgttt gagaagtttg tggaagaaaa taagcagacg attatcgact tcttcactcg
     3541 cgctgaaatg aaccgtcaga ttactttgct ggaggaaaag cacaacaact ttatctcaaa
     3601 taaggtagat agtctgtttg gctgcgatat ctggatacct tccgaactga ataactccaa
     3661 gacaggagag gacttcttct gggcatctac caatacaggc agcgcggatc gcaatttcgt
     3721 gatgtattct tatccttata ctgacaagga tacattcacc aaagaatact ttgttcataa
     3781 gcgcgattcc gtgatgaaag ccaatatccc cggatataaa gaaggcgtat atatgtcgac
     3841 agactcgtta ctgaccgatg ttcgtccgat caacgtgcac aatgactaca cgatggaagc
     3901 tcgtggattg tggcgcatga agggtgactt catgggtggg ccgttcgttt cccatactcg
     3961 tctggatcag aagaaccaac gtattattac agcagaaata tttgtatatt cacccgataa
     4021 aatgaaacgc aatctggttc gccagatgga agcatctctt tatacgctga aacttccgca
     4081 agaaggtcag cagagccaga ttccactggg ggtaaccaaa gaagcggaac caactaataa
     4141 ataaaaacat ggaagaaaac aaaataagaa tcggcattac ccaaggagat atcaacgggg
     4201 taggttatga agtgatcttg aagacattct cagaccctac catgcttgag ctatgtactc
     4261 cgattatcta cggttcacct aaagtagcgg cttaccatcg taaagcactg gatgtacagg
     4321 ctaatttcag cattgtcaac acagcttccg aagccggata caaccgtctg agtgtagtga
     4381 actgtacgga tgacgaagtg aaagtggaat tctccaaacc cgatcccgaa gcaggtaagg
     4441 ctgcattggg tgctttagaa cgtgccatag aagagtatcg tgaggggctg atcgacgtca
     4501 ttgtgacagc tccgatcaac aaacatacca ttcagtcgga agagttctct ttccccggtc
     4561 atacggagta tattgaagaa cgtctgggcg atggaaacaa gtcactgatg atcctgatga
     4621 aaaacgattt tcgtgtggct ttagtaacga cgcatattcc ggtaagggag attgccacaa
     4681 cgatcaccaa ggaactgatt caggaaaagc tgatgatttt ccatcgttgc ctgaaacagg
     4741 atttcggtat cggtgcgccc cgtattgcag tgctttcact gaatcctcat gcaggagacg
     4801 gcggactgct gggtatggaa gaacaggaaa tcattatccc tgccatgaaa gaaatggaag
     4861 agaaagggat catctgttac ggtccttatg ctgcggacgg ttttatgggt tcgggcaatt
     4921 atacccactt tgacggaatc cttgctatgt atcatgatca gggactggct ccgttcaaag
     4981 ccctggctat ggaagacggt gtgaactata ccgccggact gccggttgta cgtacctctc
     5041 cggctcatgg aacagcctat gacatcgccg gtaaaggact ggccagcgaa gactctttcc
     5101 gccaggctat ttatgtagca attgatgtat tccgcaaccg ccagcgcgag aaagcagcac
     5161 gggtaaaccc gttgcggaag cagtattacg agaaacggga cgatagtgat aaactaaaac
     5221 tggatacagt agacgaagat taagtaatag gtattaagta ataagtatta agtattagcc
     5281 atgcggatag aagcgagatg atagtgatgg taatacttaa tacttattac ttaatactta
     5341 ttacctatta cttaatatta agatagatga ccaaagcaga gatacaacaa gtgaaacagc
     5401 gtttcggtat tattggcaat accgaggcct tatcacgtgc catagatgtt gccattcagg
     5461 tagcgcctac cgatttgtct gtgctgatta ccggagaaag tggtgtcgga aaagaaagtt
     5521 ttccacagat cattcatcaa tatagccgga gaaagcatgg gcagtatatt gctgtcaact
     5581 gtggtgccat accggaaggt acgatcgatt ccgaactgtt cggacacgag aaaggagcat
     5641 ttaccggtgc tattggtgag cggaaaggat attttggaga agctgacggt ggaaccatct
     5701 tccttgatga agtgggagag ttgccgttgc ctacacaggc gcgtctgctc cgtgtacttg
     5761 aaagcggtga atttatcaag gtaggttcat ccaaagtgca aaagacggat gtacgtattg
     5821 tggcagctac caacgtgaac ctgacacaag ccattgccga aggacgcttc cgggaagatt
     5881 tgtattatcg gttgaacacg gtgcctattc agataccacc tttgcgtgag cgtggagatg
     5941 atgtgctgtt gttgttccgt aagtttgccg cagactttgc cgaaaagtac cggatgccgg
     6001 ctatccagct gacggaagat gccaagaaga tattgcttgc ttatccgtgg ccgggaaacg
     6061 tccggcagtt gaagaacatc acagagcaga tttcgattat agaaacaaac cgtgagataa
     6121 cggctgcgat tctgcagacc tatcttccgg cacagaatac ccaacgcctt ccggcactgt
     6181 tcggcacacg cgagagcaag agctttgaga gcgaacgcga aatactatat tctgtcttgt
     6241 tcgatatgcg tcaggaagtg gcggaactga agaagatggt gcacaatatg atggccgaac
     6301 gtgcgggaca agtcggacag atgggacagg tagtagctac tccggtagtg acaacgacgc
     6361 accaaccttc cgtgccggcc ataatccatg ctgtgcagca accgtctgtt tgtcccaaag
     6421 aagacgatga cgatattcag gacacggaag agtatgtgga agaaaccctt tcgctcgatg
     6481 aagtggaaaa agaaatgata cgtaaagcgc ttgagaggca tcatggtaag cggaaaagtg
     6541 cggcgaagga tctgaatatc tccgagcgta ccctttacag aaaaataaaa gaatatgaat
     6601 tggattaaga aaatagcacg accgctgata ttggttgttt taccggcagt catcatcgcc
     6661 tgtagtgtgt cctataagtt taatggctcc tctatcaatt acgataaggt gaagaccatt
     6721 tcgattgctg atttcccgat taagtcggag tatgtgtatg ctccgctggc taccaagttc
     6781 aatgaagacc tgaaagatat cttcatcaga cagacccgtc tgcaactgct aaaaccgaac
     6841 cagaatgcgg atctgcagat tgacggtgaa attacgggct acaaccagta taaccaggca
     6901 gtgtctgccg atggttactc ttcggaaacg aagctgacca tcacggtcaa tgtacgcttt
     6961 gtcaacaaca caaatcacgc cgaagacttc gaacaacaat tctcagcttt tcgtacctat
     7021 gattccagcc agctgctgac agccgtacag gatggattaa tagcggaaat gagtaaagag
     7081 ataaccgacc aaatatttaa tgcaactgta gcaaactggt aatttaatga cttctgttaa
     7141 cttgcaacaa tggattcagc atcccgagac gctgaatagg gatactttgt acgaactgcg
     7201 caaccagctc gcgaggtatc cgtattttca gtcgctccgg ttgttgtatc tcaagaacct
     7261 gtatattctc cacgacatta atttcggtgc ggaactgcgg aaagccgttc tgtatattgc
     7321 cgaccgacgg aaactgtttc atctgatcga aggcgaacgc ttcgctgtcg aatcccagaa
     7381 gaaagggctg cctctctctg aagtattgaa agatgagcct accgtcgacc ggacactggc
     7441 tctgatcgat gctttccttt cgacggctcc cgaagaagta accagtcaga caagctttga
     7501 ttactccatg gactatacgg cataccttct cgaagagaca cctgtcgtcg atgagccggc
     7561 agaggcaatg cccaagttga aaggacacga gctgattgac aactttatcg aaaaaagcga
     7621 gactgatcca gtcgtatacc tgaaaccttt gaaggaagaa gagaaagcaa aggcagcttc
     7681 ttccgctgaa acaaacgaaa cgggcagaac agacgaaaca actgaaacca acaccgtaga
     7741 agaggaagat gacagctgtt tcacagaaac tttggccaaa atctacgtaa aacagcaacg
     7801 atattcgaaa gctcttgaaa taattaaaaa attaagcttg aaatatccaa aaaaaaatgc
     7861 tnnnnnnnnn ngagaaattg attattaacg ctaattcaaa ataactaaaa atgtacttat
     7921 tattcattat cttaatggtg attgcagcct tgctgatgtg cttcatcgtg ctgattcaga
     7981 attcaaaagg aggcggactt gcttctggtt tttcttcatc aaacgctatc atgggcgtgc
     8041 gcaagactac agattttctg gaaaaagcaa cttggggtct ggctatcttc atggttgtga
     8101 tgagcgttgc tactgcttac gttgttcctt cttcttctgc agctaaagat gtattgttgg
     8161 aacaagcaca gaaagaacaa caaaccaatc cgtataatat gcctaccggt actgctgctc
     8221 ctcagacaga cgctactgct cctgcagagt ctgcaccagc aacagaagct ccggctactg
     8281 aaactcctgc tcctgcagca gaataattca gtgacaggat attcggttta aacttattga
     8341 gtgaacgggc tttttgaccc gttctcttca ttataggcgc gaattacgcg aattacaaga
     8401 gattctaata gaattgtgta atacgtgtgg ttcgcgccta tctttattat tgggtccggt
     8461 cagatgtcct ttttcttata aaatgttctc cttttttagt aaaacaaatg ataattagtt
     8521 aactttgttg cccgttacga gattattaac tccttttaaa tattacaatg acagaacaat
     8581 tgaaacaaaa gctgaatgac tccgcagtgc tgcgttggag tgttctagca ttagtcgctt
     8641 ttaccatgtt gtgcggctac ttcctcacag acgttatgtc tcctctgaaa cccatgcttg
     8701 aaaaagaact tctctgggac agtttagatt acggtttttt caccagtgct tatggctggt
     8761 ttaatgtatt cctgctgatg ctcatctttg gtggtatcat tctggataag atgggagtac
     8821 gcttcaccgg aatgggtgcc tgtttattga tggtgtttgg ttgtggattg aaatattatg
     8881 ctattactac tactttcccg gaaggtgcga tgcttttcgg attcaagatg caagtcacat
     8941 tggctgcatt gggctatgct attttcggtg taggagtcga aattgcgggt atcaccgttt
     9001 cgaagattat cgtgaagtgg tttaaaggca aagagatggc tctcgctatg ggactggaaa
     9061 tggcgaccgc gcgtattgga acaactttgg ccatggtgct taccgttcct ttggcagact
     9121 tcttcgggtc tacggatgag agcggcgtat tccataccaa tattcccgct ccgattctgt
     9181 tctgtctcgt catgctgtgc gtaggtacca tcgcattctt catctatact ttctatgata
     9241 agaaactgga tgcttcactg gatgcggaag gactggaacc ggaagaacct ttccgcatga
     9301 aagacatcgt atatatcatt accaacaaag gattctggct gatcgcatta ctgtgcgtat
     9361 tgttctattc ggctgtattc cccttcatca agtatgcggc tgatttgatg gtacagaagt
     9421 acaatgtaga tccgaaactt gcgggaacga ttcccggatt gctgccgatt ggcgcgatca
     9481 tcctgacacc gttgttcggg tcattgtatg accgtatcgg taagggagcc acgctgatgg
     9541 tgatcgggtc ggtgatgctg attttcgtac acactatgtt cgctcttcct attctgaata
     9601 tctggtggtt tgcaacggtg atcatgatta ttctgggatt tgctttctca ttggttcctt
     9661 cggcaatgtg gccttcggtt ccgaagatta ttccggagaa acagttggga acggcttatg
     9721 cgttgatctt ttgggtacag aactggggat tgatgggcgt gcctttgctg attggatggg
     9781 tgttgaattc ttattgcaaa ggtccggttg tagatggtgc acagacttat gattatacct
     9841 tgccgatggc tatttttgct atgttcggtg tacttgccct gattgttgcc ttgatgctga
     9901 aagcagaaaa caagaagaaa ggctacggac tggaagaagc aaatattcag aaataatcac
     9961 agtatatatt ctatctgaaa agatataaaa gagaaaagat atggcaacga aagagaaaat
    10021 aaacctcctg gaggtgatcc cttgtcgtaa cgaacatatt aaagctgaac aggaagggga
    10081 gactattgtg ctctccttcc ctcgttttaa acgttcgtgg atgagtcgtt atttattgcc
    10141 gaaaggaatg tccaaagata ttcatgtgcg tctggaagaa cacggtacgg ctgtatggaa
    10201 cctgatagac gggcagcgga cggttcgtga gattatagaa aaactcgcag accactttca
    10261 atatgaagca ggctacgagt ctcgtgtatc tacctatctt tcccaattac agaaagacgg
    10321 atttattaaa tggataatta tccattaaaa aagattgccc acaggaggac agcacatcct
    10381 atcagtacgc ccataatgat aagcgttccc catacgaaat agctgttatc tttttctttt
    10441 ttcttttccg aatccttgat gatgcgttcc atctcttccg gagtcgtatc cggcagaaga
    10501 taagggtcgt tgtttcttct aagtcgccct aacttgtcat ttctccgttc acggcgtaag
    10561 cgggaggctt ctttgccgtc tttcagccga cgtatcatgt cgagcatatg tccttcgcca
    10621 cccatcgttt tgttttttta gaggttttat ttgctttctt ctctatctac tttcagtagt
    10681 ccaccggtca ccggatcaaa gtaaactttg atggtcgagt tcttgttgaa taataccgga
    10741 gcaaggtatt ctatgatacc gaactgagta acaggtattt ctccttcata caatttcttt
    10801 ttgccgtccg tcagcgtcac cattgcctgt cccggtacgt tataagcaat gccttccatc
    10861 tctttcttct ttttcccgtc ctcttgcgga atcttcaccg ttttcaggtc tttcagactg
    10921 atgtagaatg gagtgcctgc caaatcgttg ttggcaacta tacccagctt ctttgaaaag
    10981 cggaaagcta cctcattgtc gaattcctta tccggagtga ggcggacagt aaatgtcttt
    11041 tcttctttat tgcggactcc cgaaaacatc tcggtcatgg cttcttcctg aagattcagg
    11101 ttgtcgagca tgattttgag ctgtgcgccg tccgaaggca tattatctgc ttgtccgcgc
    11161 aataatgcgt ttttactttc gcggatatta tagatttcct ttgctaccag ttcggccatc
    11221 ttggcggttg aacttgccat cagaatttct tctgtgagaa agtcgcgggg attggctttt
    11281 cgttggggag caacggcatt gtttgctgca ttctttgcat tgttactgct gtaggggacg
    11341 ttgattgatt tgataagacc ctcttcagtc agttccataa gaggagctac ggttttgtct
    11401 ttcagtttga cgaaataagt agcttcgctg tttggtacac ctacaggttt cactttgaca
    11461 ctgttcagtt cccagtattc ttcgggttcg gcagagacgt tggtcagtct caggtagcgg
    11521 tcggcgtatt tgctgaattc acccggctta tagttgactt tgtttgcttt tatttctatt
    11581 tctatctggg ttttggggag ggcgtacact actccgtagt cttttcctcg cgtcactcct
    11641 gtcagcactt cggtctgcgc ataggcggaa gttgccatta gtagtcctgt tgctatgatt
    11701 aactttttca tattcggttc tttttagctg attttgaaaa acaaagttaa tgaagttatt
    11761 gaataaaccg taagttctta acttttattc gcttacaagt cgccatgccg tcggcagaca
    11821 ggtgacgata tcacttgcga ttaatccgat catgccctgt tttttctggg cgatgtctcc
    11881 ggccaatccg tgaatgtaag taccgatctt tgcggcgtct tcggcgggat agccttgcgc
    11941 aaggagtgca aggattactc ctgtcagtac atctccgctg cctcctgttg ccataccggg
    12001 attaccggtc tggttgaagt aacatttgcc ttcgggggtg ataatggcgg aataagctcc
    12061 cttcagaatg atatgtactt tggcagtgtg cgccagttcg caggctttca tcagtcgttc
    12121 gtatgagtcc tgacatttgc cgaccaggcg ttccagctct ttcgggtgag gggtgaggat
    12181 ggaacctttc ggcagatggg tgagcgtatg ccggtgattg gccagaatat tgagtgcgtc
    12241 ggcatccagt accgtcggag tctgacaatg ttccagttgt tctatcaggg cggcttccgt
    12301 ttcctcgttg cgaccgagtc ccggaccgat gccgacagct tggtaatcgt ccgtatcggt
    12361 aggtacggca aagcatgttt cgctgacatc tgcttctacc atggcttcgg gggcggacgt
    12421 ttgcagaata tcgttgttgc ataacggcgc gtgtacggtc agcagaccta ctcccgagcg
    12481 cagacaggca cgcgcggcca gtaccgatgc acctgccatt ccttttgagc cggctatcag
    12541 cagggcatgt ccgaagtttc ctttatgggc gaattgttgg cgtggtttga tcagtgaacg
    12601 gatttcttcg atttccagca tttcgtagtt tgtttcagtc tcttcgattc cttcttcgct
    12661 cagctggatg tccaataact cccattcgcc aacaaattct gtattttcgg caaagaggaa
    12721 ggccagttta ggaagttgca ggctgaaagt gacgtccgca cggataatat tgctttttac
    12781 attgaatgta ttttcttctc ccatcagtcc ggaagggatg tcgatggaga ctaccatggc
    12841 gggagaggca ttgatatatt tcacaacggc agcgaatcct ccgctcaatg gtttgttgag
    12901 tccggaaccg aataatccgt cgatcacgag atgttccggt gtcagtgtgg gaggtacgaa
    12961 ctgggtgctg atttcatgga aagttacttc ttccatcatc tctaccagtt ctttgttggt
    13021 ctggcagtcg ggcgaaagtt cgcctttcgt gttgaagaga tatacttcga tcttgtatcc
    13081 tttttccgcc atcatgcggg cgatggcgag ggcgtctccg ccattattgc ccggtccggc
    13141 aaagatggtg acaggtgttt ccggattcca tctgttggtg atggctttag tcagcgcctg
    13201 tgcggcacgc tccattaaat ctatggatgc aatcggttca tgttcaatgg tataggcatc
    13261 taacttctta atgctgctgc ttggaaatat tttcattgcg atattctttt agttttcgac
    13321 gcacaaactt acacaaaaac tctgaattaa tcctttattc cggttggttt tcggctttag
    13381 ataaagtggc aaattgaaaa atgcagggga aatcagaagt tatcttgggg tggctttgtc
    13441 ctgtctgtct gtgattcctc agttgggggg cggatatttc tctgcaaagg tacgggcatt
    13501 cttcagataa gatgcggaga cttttcggct aagatgcagg cattcttctc ttaaagtgcc
    13561 tcagggaaaa cgcattataa atcatgtaaa ataagttccc ataagaattc atta
//
