LOCUS       gnlProkkaHFDFCLLF_70   10635 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HFDFCLLF_70.
ACCESSION   gnlProkkaHFDFCLLF_70
VERSION     gnlProkkaHFDFCLLF_70
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 17:45:31
            Original ID  :: gnl|Prokka|HFDFCLLF_70
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10635
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10635
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1321:5635]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1322..5635
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..10635
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10635
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             110..1258
                     /locus_tag="ctg70_1"
                     /transl_table=11
                     /translation="MSEQRQDKNLLSEPHKTESDEIEIDLVDIFRKIIAIRKKLYKAVG
                     IGFIIGIIVAVSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVLFGKSLLASLRKELKNKEIEQDK"
     CDS             1322..2041
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.8; E-value:
                     3.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg70_2"
                     /sec_met_domain="NTP_transf_3 (E-value: 3.4e-17, bitscore:
                     52.9, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CGIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLIAPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             2062..3363
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 209;
                     E-value: 1.4e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg70_3"
                     /sec_met_domain="CTP_transf_like (E-value: 1.8e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 7.7e-122, bitscore:
                     395.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 9.6e-64, bitscore:
                     204.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKTILENERALEVRELCMPIKEILELIPGTK"
     CDS             3380..4504
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg70_4"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 8.7e-21, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             4514..5635
                     /NRPS_PKS="Domain: Aminotran_5 (30-365). E-value: 1e-33.
                     Score: 108.6. Matches aSDomain:
                     nrpspksdomains_ctg70_5_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 75.3; E-value:
                     7.1e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg70_5"
                     /sec_met_domain="Aminotran_5 (E-value: 4.7e-31, bitscore:
                     97.6, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEFGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        4604..5608
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg70_5_Aminotran_5.1"
                     /evalue="1.00E-33"
                     /label="ctg70_5_Aminotran_5.1"
                     /locus_tag="ctg70_5"
                     /protein_end="365"
                     /protein_start="30"
                     /score="108.6"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEFGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNH"
     CDS             5632..6105
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156:Chloramphenicol acetyltransferase (Score: 73.7;
                     E-value: 2.7e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg70_6"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYSNIY
                     LGKNAEIRSGCYLIARDKIIIGENSTLAYGTTILTTADPNGPYNALAVLYPYKKAPVVI
                     GDNVWIGANVTILPGVTIGDYVVVAAGAVVTKDVPSGVLVAGVPAIVKKRFNK"
     CDS             6102..7547
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg70_7"
                     /sec_met_domain="Polysacc_synt (E-value: 7.7e-33, bitscore:
                     103.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEKTSLKNKAICGIFWSAVERFLSQGIQFVVTVIMARFLLPSDY
                     GMVGMLAIVLQLSQTLMDSGFTNALIRYKERTEIDYSTVFFFNILASLVIYFLIFFLAP
                     YISWFYKIGQLVEITRILSIVIVLNSFAIIPKTKLIIAVDFKTQSKVSFIAALVSGIIG
                     IWAAYLDFGVWALVGQTLVNGLLIVVLYAYFCRWKPLWIFSLKSFRLLFAFGSKLVLAN
                     ILNTLYKNLYAIVIGKKFSSVDLGFYTRAEQFAQFPSYNLSAIISRVTYPILSLVQNDN
                     DRLSALYRKYVRLSSAFIFPLMILLIVIAQPLVLLLLTEKWIGVVVLLQILCLDWMFDH
                     LSSINLNLLYVKGRSDLALRLEVIKKVLATGILLLSIPWGIVGMCWGRVMYSLIAVYLN
                     TYYTESLIKLSLIRQMRDILPSFFLALIMGGGTWYMILLLEGEIVQIVVGSVIALLLYG
                     TLLYCFSRSLFDEIWAVILKIKR"
     CDS             7547..8269
                     /locus_tag="ctg70_8"
                     /transl_table=11
                     /translation="MDKLSLIISKIRRNHWYRTYMRPIYLFVYGNRKLKNRNRIFLQYS
                     QELLTNFHQAMNEVGIPYWLEFGTLLGAVREHSFISHDFDLDVGLFKEDYSDIIREVLK
                     KYGFKRIRCITALDFIDAYEETYLYKGVTIDLFLFSREKNCDGVYCYDFVPVYSDIKRT
                     KKGDNAIRRIHFPRIDLIEYSFIGINTFVPENYEEHLCMHYGKDYMIPNPHWKDSDAQH
                     TDIFYGREIRIELFDKSK"
     CDS             8283..9296
                     /locus_tag="ctg70_9"
                     /transl_table=11
                     /translation="MFYLFFLLIVLFLLYIQSRKRQYSTVAGICVPIIIIFVVICRYRV
                     GYDYLTYYTLIENEEEAQILYLFSPLSIVWAEIALYFESPQMLFVLFGLPTFALLIFTL
                     KKYSKDYALSVTILICFFFFTSLSIIRQALALAICFYGYRFIVKRSLIKYILCILIAAL
                     FHPSAGVAIIIYWLPFLKFRLVVLLSIISIVAKPLFFYMLNILGVYTSYLDGKMDIEGG
                     KYTQLIYFLLFIICFVLGSKNIDKNKCNLFNVLLLSFVFVSFLGAHLGGRIAFYFNIYY
                     CLLIPKVVKGLDGQLREQVKLLSYFLCISYFLLYLFVPFIKGVPSYYIPYKFIFFK"
     CDS             9301..10260
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123:polyprenol-monophosphomannose synthase ppm1
                     (Score: 57.2; E-value: 3.2e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg70_10"
                     /sec_met_domain="Glycos_transf_2 (E-value: 9.4e-43,
                     bitscore: 135.7, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLISIIVPCYNSERYLSDCLLSILNQTYVNWEVICIDDGSQDNTL
                     SILNHYATLDERFKIISQSNAGVSVARNKALSQCQGEYICFVDSDDLIEPNFLITLLQL
                     ISHQADLAICGFTRSMVFCMDDAQGYIEMSGKRCIERIILDKSFNPQICCMLFRHNIIK
                     EKQLEFVIGCTRGEDREFILKYLVYSNKVCYTNNLLYHYRVNDQSAMAIFSIKSLTSIE
                     ASQRTVNYYKKVNYSVRGLEFEFSRTLWKFMILAILSGQNDLYQIIREKYDLKRQMEHL
                     YSHPGLSEKLTARLFVWNEALFKWVFSIIRYLYKKRWR"
ORIGIN
        1 agaaagggaa catagctaat attttaggtt atgctacttc cttcagttct ttgggtatga
       61 tgattgcttc tattgctaat cttataaaga aataatagaa tttactttta tgtcagaaca
      121 acgacaggat aaaaacttgc tctctgaacc acacaagaca gaaagtgatg agatagaaat
      181 tgatttggtc gatatctttc gcaagattat tgctattcgt aaaaaattat acaaagccgt
      241 tggaattggt tttattattg gaataattgt agcggtaagt atccctaaac agtatacagt
      301 aaaggttacc ctttctcctg aaatgggtaa tgcgaagggg agtaatggtt tagccggact
      361 tgctgcctcg tttttaggag atggggctct aataggggaa agcacagatg ccttgaacgc
      421 ttctctttca gcagatattg tttcttcaac tcctttttta ttggaacttt tagaaatgga
      481 agtctccgtt tctaaaaagg atgataaaat gactttgggg tcttatctcg atgaagagtc
      541 atctccttgg tgggattatc ttataggttt tccgggcata gtaataggag gagttaaatc
      601 attattcgga gaagatacgg ttcctgccag tggagggcgg caaggaacta tcgaattgac
      661 gaaagaagta aatgagaaga ttaattttct taaaaagaag attagtgcat ccattgataa
      721 gaaaaccgcc ataacgagca ttacggtcac cttacaaaat ccgcagatca ctgcggttat
      781 agcagattct gtcgttcata aattacagga atatattatt gggtatcgaa cttcaaaagt
      841 aaaagaagac tgtgcgtatt tggaacggtt gtttaaagaa cgtcagcagg aatattatgc
      901 tgctcaaaga aaatatgcgg attatgtaga cgcccatgat aatgtggttc ttcaaagtgt
      961 acgtgctgag caggagcgtt tacagaacga catgagtttg gcttatcaga tatatagtca
     1021 ggttgctaat cagttgcagg tatccagagc caaagtacag gaggaaaagc cagtctttgc
     1081 agtagttgag cctgccgttg tacctttgaa accttcaggt atgggactca aaatttatat
     1141 tttattattt gtgttcctgt ccgtatctgg tactctcgtg tgggtgcttt ttggcaaaag
     1201 tctgctggct agcttgagaa aagaactgaa aaataaggag atagaacagg ataaatgatg
     1261 ctaaaacgtc gtttacaaca ttcttatatc aattaaattc acttactata ttattaaacg
     1321 aatgatacgt acagctatga taatggctgc gggcatggga acccgttttg gccaatatac
     1381 agaattgata cctaaagggt tcgtcaaagt gggaggtatt ccaatgatag ttcgttctat
     1441 tgatactttg ttatcatgtg gcattgagcg aattgtaatc ggtacaggat ataaacaaga
     1501 agtttatgaa gaattgaaga cagactatcc tatgcttgaa acctgtttta gtcctcgtta
     1561 tgctgaaaca aatagtatgt atactttata taatacgcgg gagattctgg gcaatgatga
     1621 ttttttattg ttagagtcag atttgatttt tgagaaacaa gcaataatga gcttattgga
     1681 gtgtcctgcg gcagatgcaa tgctaatagc tccagtgaca aagtttcaag atcagtatta
     1741 tgtggaacat gatgataatt ttcgcctttc ttcatgttct gtcaataaga ataaactaaa
     1801 cgctaaaggc gaattggtcg gcatccataa actatccggt tccttttaca aaataatgtg
     1861 tgctgattat gcgagtattg ttgatgaaca acccaatttg ggatatgagt atgaattact
     1921 acgaatatct tgttctcaat ctcctgttta tgtgcataaa gtagaagggc tgaaatggta
     1981 tgaaatcgat gacatatcag atttggaata tgcagagaaa tatattgttc cgtattgtta
     2041 attaaaataa tatatcaaat tatgagtaag acagtttata ttgggatgac tgcggatatt
     2101 atgcatccag gacttatccg cattattaat gaggctacta aatacggtga tgttataatt
     2161 ggtcttctta cagataaagc tattgcggag cataaacgcc ttccttatct gacctatgaa
     2221 caacgaaaag aggtagttca gaatattaaa ggcgtatgta aagttgttcc tcaagaagaa
     2281 tggagctatg ttgagaatct caaacgcatt aaacctgact atataattca tggtgacgac
     2341 tggaaaaccg ggcctttacg tgaagaacgt gtgcgcgtat ttgaagtgat gaatgaacag
     2401 ggaggaaagg ttatcgaaat tccatatact ttgggaatta attcatcttc tttggataaa
     2461 gatattaagg ctataggtac aacccccgat gtacgtttaa aatcacttcg tcgtttgata
     2521 aatgccaaac ccgtagttcg tattttggaa gctcatgatg gactatgtgg cttgataatt
     2581 gaaaatcagg aaatattaaa aggggataag agggaagtat ttgacggaat gtggtctagt
     2641 agccttacgg attcaaccag taaaggtaaa cctgatattg aggcggttga tttaactacc
     2701 cgattgcaag atttgaataa tattctggag tgtactacta aacctattat ttttgatgga
     2761 gatacaggtg gtaaaattga acatttcgta tttacagtac gcactttaga acgtcatgga
     2821 atctcagcta taataattga agataaagtt ggattaaaaa agaattcatt gtttggtacg
     2881 gatgttattc aaactcaaga tacaatcgaa ggtttctgta ataagatcaa agcaggaaag
     2941 gcatctcaga ttactgatga ttttatgatt atcgctcgta ttgagagcct tatagcggga
     3001 aagccggtaa gtgatgcttt agagagagct tttgcatatg tccaagcggg agcggacggt
     3061 attatgatac atagcaaaaa taagtcgggt gaagatataa aagaattttg tttggcgttt
     3121 cgaaaacagt atgctcatgt acctatcgtg gttgtgccta ctacatatga tcatatttat
     3181 gagtctgaat tgtgtgattg gggtgtgaat ataattattt atgctaatca tatgcttcgt
     3241 gccgcttatc ctgctatgat gaatgtcgca aagacaatat tagagaatga acgtgcttta
     3301 gaggtgcgcg aactgtgtat gcccataaag gaaatattgg aactgattcc gggtactaaa
     3361 taaaaagagg aatatcatta tgttaagcgt agaaaaagtt tatgaaacgt ttctgagtca
     3421 tgacgttgat ttttttacag gagttccaga ctcattacta aaaaatattt gtgcctatat
     3481 cacagaccat acttcacgtg agaaacatat catagctgct aatgaaggtg cggctgtagg
     3541 aattgcttca ggttattata tggcatcagg taaggttcct gtggtttata tgcaaaattc
     3601 cggcttgggt aatactgtta atcctctgct gtctcttgca gatgaacaag tatacagttt
     3661 tccaatgctt ttgatgattg gctggcgtgg tgaaccggga acaaaagatg aacctcagca
     3721 taaaaaacag ggtgaggtaa ctttagattt gttgaaagca atgcggattc cttatataat
     3781 tcttgattca aatgagaatg atgcatttat tcagctccat gatatcatac aatcagcaaa
     3841 aactaagaat attcctcatg caataattat tcggaaagat gtttttggca aatataaact
     3901 tcaaaaagag ttcggatgta attatccttt atctcgtgag gatgctttgc aaatagttgt
     3961 ggattatctg cctgaaaatt cagtggtcgt ttctactact ggcaagcttt ctcgtgagtt
     4021 atttgaatat cgagaaatga aagagcaagg tcatgaacat gattttctca cggtaggctc
     4081 tatgggacat agttcatcaa tctctttggg tattgctata gcaaagcaag atagacctgt
     4141 ttattgcttg gatggtgatg gagcatttat tatgcattta ggggcaatta gtaacattgg
     4201 cgatttatct cctaaaaact attatcatat tttgtttaac aatggtgctc acgagtctgt
     4261 aggaggacag cctactttag gatttagttt agatattccg gctattgtcc gggggagcgg
     4321 atataagcat acttatactg tttgtacaaa agttgaaatt gaagaagcaa tgaagcagct
     4381 tccaaagtta tgtggtcctg ttttgttgga aataaaggtt aaaatagatt ctcgggagaa
     4441 tttgggacgt cccacgacta ctcctataga gaataaggag cattttatgg attttttaaa
     4501 ataaatatat tcgatgaaaa tagaaagaaa aatattatta aatcctgggc ctgccactac
     4561 tactgacagt gtaaaaatgg cacaagttgt tccggatatt tgtcctcgcg agaaagaatt
     4621 cgcaggtatg atgaaacaac ttcgggacga tttggtcaga gttgctcatg ggaatttgga
     4681 aaaacatacc gctgtattat tttgtggctc aggaaccatc aatattgata tatgtctaaa
     4741 ttctcttctt cctgaagaca aaagggtgct tatagtgaat aatggggcat atagtacccg
     4801 tgctgtagaa gtgtgtcaat attatggttt gcctcatatt aatttggaat tttccgttta
     4861 cgaacgtcct gatttatcgg tggtggaaaa tgtgttgcaa gaaaatcctg atatagctat
     4921 ggtttatact actcatcacg agacgggtac aggaattctg aaccctattc gcgagatggg
     4981 cgctatagct cataaatatc aggctaaatt tgtcgtcgat actacttctt ctttgggcat
     5041 gattcctttt gatatagaga aagataatgt ggatttttgt atggcatctg ctcaaaaagg
     5101 acttcaagcg atgacaggtc tttcttttat tataggcaat gaggaacaga ttaagttttc
     5161 aaaaaaatat cccaagcgtt cttactattg taatctttat ttgcagtatg agaattttga
     5221 gagaacaggt gaaatgcatt ttactccacc ggtacaaact atttacgcca ctcgtcaggc
     5281 attaaatgaa tattttgaag tgggcgaaga agctaagttt gcccgtcaca aaagagtttt
     5341 tgaggctatt cattcaggta taaatgaatt tggtcttaaa agtgtaataa agcgtgaatg
     5401 gcagtcagga ctggttgtct cagttcaata cccagaagat cccaactggg attttgagaa
     5461 aatacatgat tattgttatg agcgtggatt tacgatttat ccaggtaaga tatcaactga
     5521 ggatactttt agaatctgtg ctttaggaga gatagaagta gatgatattg agaacttctt
     5581 taaagtacta aaagctgcat taaatcatta taacgtcaca ttaccgatgt catgattgca
     5641 gaaatattat tgaagattcg tcatttttat ttttcccttc gtggtataca cttccatccg
     5701 gaaagtgtta tttctggagt gcctattcgt agctttcgct tagtaggcaa atatagcaat
     5761 atctacttag gtaaaaatgc tgaaatacgt tcaggctgtt atctgattgc tcgtgataaa
     5821 atcattattg gagaaaactc aacactcgcc tatggaacga ctatattgac aactgctgat
     5881 cctaatggac cgtataatgc attagcagtt ctttatcctt ataaaaaggc accggtagtt
     5941 ataggagata atgtttggat tggggctaat gttaccatcc ttcctggagt aactattggt
     6001 gattacgttg tagtagcagc tggagctgtt gtaacaaaag atgtaccttc aggagtattg
     6061 gtagctggtg taccagctat tgtgaaaaaa cgttttaata aatgaaagaa aaaacttctt
     6121 taaagaacaa agccatatgt ggaatctttt ggagtgcagt tgaacgattt ttatcacagg
     6181 ggatacagtt tgtagttaca gtcattatgg cgcgttttct attgccatct gattatggaa
     6241 tggtaggaat gttagcaata gttcttcaat tatctcaaac gttaatggat agtggtttta
     6301 ctaatgccct tattcgttat aaggaacgta ctgaaattga ttattcaaca gttttctttt
     6361 ttaatatatt agcatcatta gttatttatt ttctaatttt ttttctagct ccttatatat
     6421 cgtggtttta taaaataggt caattagttg agattactag aattttatct attgttattg
     6481 ttttaaattc ctttgcgatt attcctaaaa ctaaattaat aatagctgta gattttaaaa
     6541 ctcaatcaaa agtctcattt attgcagctt tggtttcagg tattattggc atttgggctg
     6601 catatttaga ttttggagtt tgggctttag ttggacaaac tttagtaaac ggattgttga
     6661 ttgtagtttt gtatgcatat ttttgtagat ggaaaccatt gtggatattt tcattgaaat
     6721 cgtttcgttt attatttgct tttgggtcaa aattagtatt agctaatatt cttaatactt
     6781 tatataaaaa tctgtatgct atagttatag gaaagaagtt ttcgtcggtt gatttaggat
     6841 tttatactcg tgcggaacaa tttgctcagt ttccttcata taatttgagt gcaataattt
     6901 ctagagtgac ataccccata ttgagccttg tgcaaaatga taatgataga ttatctgctt
     6961 tatataggaa atatgtccgt ttatcttctg cttttatctt tccattgatg attttgttaa
     7021 ttgtcatagc tcagccactg gtattattgc ttttgacaga aaaatggata ggagtagttg
     7081 tattgcttca aatattgtgt ttagattgga tgtttgatca tttgagtagt ataaatttga
     7141 atttactata tgtaaaggga cgttcagact tggctttacg tttagaagtt ataaaaaaag
     7201 tgttagcgac ggggatcctt cttctatcta ttccttgggg gattgtaggt atgtgttggg
     7261 ggcgtgttat gtattcattg attgctgtgt atttgaatac ttattataca gaatcattga
     7321 ttaaattaag tcttattaga cagatgagag atatactacc aagctttttt ttagcattaa
     7381 taatgggagg aggtacttgg tatatgattt tattgttaga gggtgaaatt gttcaaattg
     7441 tagtaggaag tgttattgct ttattgctat atggaacgtt gttgtattgc ttttctcgat
     7501 ccttgtttga tgaaatatgg gcggttatat taaaaataaa aaggtaatgg ataaactgag
     7561 tttgattatt agtaaaatac gacggaatca ttggtataga acctatatgc gtcctatata
     7621 tttatttgtt tatggcaata gaaaattgaa gaatagaaat agaatatttt tgcagtattc
     7681 acaagagctg ctaactaact ttcatcaagc aatgaatgaa gtgggaattc cttattggtt
     7741 agaatttgga actcttttag gtgctgttag agaacacagt tttataagtc atgattttga
     7801 tcttgatgtg ggccttttta aggaagatta ttcagatata ataagagagg tcttaaaaaa
     7861 atatggtttc aaaagaataa ggtgtataac cgcccttgat tttattgatg cttatgagga
     7921 aacttatctt tataaaggtg tgacaattga tcttttcctt ttttcaagag agaaaaattg
     7981 tgatggggtc tattgttatg attttgttcc agtatattca gatataaaga gaactaaaaa
     8041 aggtgataat gcaatccgga gaattcattt tcctagaatt gatttgattg aatattcatt
     8101 tattggaatt aatacttttg ttcctgaaaa ttatgaggaa catctttgta tgcattatgg
     8161 taaagactat atgattccaa atcctcattg gaaagattca gatgcgcaac atactgatat
     8221 cttttatggt agagagatta gaattgaatt gtttgataaa agtaaataat agtagataat
     8281 acatgttcta tctatttttt ttactaattg tgctattttt gttatatata caaagtagga
     8341 aaagacaata ttctactgta gcgggaattt gtgttcctat tattataatt tttgttgtaa
     8401 tttgtcgtta tagagtgggg tatgactatt taacgtatta tacattaatt gaaaatgaag
     8461 aagaggcaca gattttatac ttattttctc ctttaagcat tgtttgggca gagattgctt
     8521 tatattttga atctccacag atgttatttg ttctttttgg gcttccaaca tttgctcttc
     8581 taatatttac tttaaaaaaa tattcaaaag attatgcgtt atcagtaact attttaattt
     8641 gtttcttctt ttttacatca ctcagtatta ttcgacaagc tttggctttg gctatttgtt
     8701 tttatggtta tcgttttata gtaaaacgtt cactaattaa atatatatta tgtatattga
     8761 ttgcagcttt attccatcct tctgcaggag tagcgattat tatatattgg ttgccatttc
     8821 taaagtttag attagttgta ttattatcta taatatcaat agtagccaaa cctttatttt
     8881 tttatatgct aaatatatta ggggtgtata cctcttatct tgatggcaag atggatattg
     8941 aaggtgggaa atatactcaa ttaatatact ttttgttgtt tattatttgt tttgttttgg
     9001 gaagtaaaaa catagataaa aacaagtgta atttatttaa tgttttattg ttaagttttg
     9061 ttttcgtatc ttttttagga gctcatttag gcgggagaat agcgttttat tttaatatat
     9121 attattgttt gttgattcct aaagtggtta aaggattgga tgggcaacta agagagcaag
     9181 tgaagcttct ttcttatttt ctatgtattt cttatttctt attgtaccta ttcgttccat
     9241 tcataaaagg tgtaccctca tattatatcc catataagtt tatatttttc aaatagtaaa
     9301 atgttgatat ctataattgt cccttgttat aattctgaaa gatatttgtc tgattgttta
     9361 ttgtctatat tgaatcaaac ctatgttaat tgggaggtga tttgtataga tgatggaagt
     9421 caagataata cattatctat tttaaatcat tacgctacat tggatgagcg ttttaaaatt
     9481 atttctcagt ctaatgcagg agtgtctgtc gcaagaaata aggctctatc ccagtgtcaa
     9541 ggagagtata tttgctttgt tgatagtgat gacctgatag aacctaattt tttgataaca
     9601 cttttacagc ttataagtca tcaggctgat ttggcaatct gtggttttac tcgttctatg
     9661 gttttctgta tggatgatgc tcaaggatat atagaaatga gtggtaaacg ttgtatagaa
     9721 agaattattc tagataaaag tttcaatcct cagatttgtt gtatgttatt tcgacataat
     9781 attataaaag agaaacaatt agaatttgtg atagggtgta ctcgtggtga agatcgtgaa
     9841 tttatattga aatatttagt ttattctaat aaggtttgtt atacaaacaa tcttctttat
     9901 cactatcgtg taaatgatca gtcagccatg gcaatctttt ctattaaaag tttgacaagt
     9961 atagaagctt cacaacgcac ggtcaactac tataaaaaag tgaattattc tgttagaggg
    10021 cttgaatttg aattttcacg tacattgtgg aaattcatga ttttagctat tttgtctggg
    10081 caaaatgatt tatatcaaat cattcgagaa aagtatgatc taaaaagaca aatggaacat
    10141 ctttattctc atccaggact atccgaaaaa cttacagcga gattgtttgt ttggaatgag
    10201 gcacttttta aatgggtatt ttctattatt agatatctat ataaaaaaag atggagatga
    10261 ataaacgaaa tagattatct gaacaagaaa taaaaaaagt agaacttgac gctttattgt
    10321 atattcggaa aatttgtcag caatatcatc ttcgctatta tttagcttgg ggtactttgt
    10381 tgggagccgt taggcataaa ggatttattc cttgggatga tgatattgat ataatgatgc
    10441 cacgttcaga ttatgagcga ttattggagt tagttccttc cttgagacat agttattata
    10501 aaatcttaag taatccaaag aatgaggatt attattatac tcatgcaaaa atgatagata
    10561 ctcgtacttt gtgtgtggaa aatgatttgc aaactattca aaatatgggg atttgggttg
    10621 atattttccc cttag
//
