LOCUS       gnlProkkaENNLKEJC_69   15661 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ENNLKEJC_69.
ACCESSION   gnlProkkaENNLKEJC_69
VERSION     gnlProkkaENNLKEJC_69
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 18:22:57
            Original ID  :: gnl|Prokka|ENNLKEJC_69
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 1045
            Orig. end    :: 16706
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15661
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[5000:10661]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..10661
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..15661
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15661
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             113..1351
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg69_3"
                     /sec_met_domain="Polysacc_synt (E-value: 3.2e-12, bitscore:
                     37.4, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRIITSQFFKDFMSLITNRGLDSLIGIIVIPYLILKIGEVEYGR
                     IVLAQSIVYLGVAFVNYGLDFLILKKVPLYMYFQKMRPISIFMYRIILLRFAIFLLYLV
                     LYYILQCVFGFSSELNLYFSILSLICLAEVFSVSHFLVVFQNVKILPWVSAFRFLFLFL
                     FTYIFVRKENDAYRYICFYSISYLFSNLVVLFYTVLKYKLHYFKLPSIGALKKIFFKSS
                     PFFISKLNLILSDKLYNILCATFVSLSAAALLDISFKVLSIIIIPVQILSVVILGRFFM
                     RTSQEVIKRVLSFILFFSLFLFIILFIAKRYILTYYSFSLVSDVLWSFSLVLFSSLFAN
                     LSVFIGDNIMISNSLEKQLIKSSIYSSLFVFPLLIITLCFVDNSLFTLSVFFLFHKILE
                     FLLRVYYSWNYIN"
     CDS             1333..2724
                     /locus_tag="ctg69_4"
                     /transl_table=11
                     /translation="MELYKLKNRNNIILLLKIQYLNFALSILLFIVNLISGATINYLFF
                     SYYLLFSFLYITVVSLKVFSLASAFNLFLFGYFMFQISALFVSLDTLLERKLMDNLFLF
                     SEEQINNTLCANSIILNAMFLGCLMSIIYLPIKTNINKANLIYSERLQNWGYLLFWAAL
                     PFTLLKFYLEIKLVLTEGYYAYYTSSLSIPFLISISRFIFEIGFFLFLTSLPPKKKFLT
                     VSKVYILVMCLFFLIGVRNRVILSFLFVLWFYYRFYSKKSPKILFLLIISISSVALLLL
                     VQLVRQAGVFLLSDDRSIFSYFFYAQSTNFYILPLLQYYDLHTEVPFVFAPFFNLDTSY
                     YDPNGINNLLGNAIAFRISPDEFREGHGLGSSFIAELYDLGIVFMSILSIGLGFVMGWF
                     ERNVKNNRALLAISFYAITNCIYISRSSLFRNVYMFPLLIILVFIALKIRYPFKMKKNE
                     YPTRL"
     CDS             2702..3826
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg69_5"
                     /sec_met_domain="Glycos_transf_1 (E-value: 2.4e-24,
                     bitscore: 76.8, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNILHVSDIDVSSCGGGMNTVIPELIMRQLLYDSTLNETLFITRK
                     KYKIAKQIPYFICFMEGNFLKYLQKSDLLVFHSVYNLKFILLYFFCKKNKLPYLIVSHG
                     GLSKVALKKGIIKKKLFKFLFLNRFVKDATVLCFTSLEEQLSSVYTDKKYIIVPNPIQI
                     SDYSYRLDVSNNDEVKMIFLSKIDFYYKGLDVLFDALNIIKEDIVNANVFLSFYGYGKN
                     KEVDVENINSAEKDILKLILRIKELNIGERIKYCGPVFGHQKMEVLKNSDIYVLTSRSE
                     AMPLSISEALSVGTPCLVTHGTNMSNLIEQYKAGWSSSLNKEDLAFNILKAIKEYKDSP
                     VTFRKSARGLYEYNSSIDVGKVSIDQYKTILEEK"
     CDS             3826..5010
                     /locus_tag="ctg69_6"
                     /transl_table=11
                     /translation="MLYYFRIFISYLLYEFGVRRKDIIIFSGYKNLKYNFNSRYLFEFF
                     LEKKSNLKCFFVIDDDNLRRRLNEIVGDYFVTTNSWKDLKLIFSAGTWITSGGLPIRIP
                     YVNRNRVVVNLWHGLPFKGIGLLNNENTCLQNLLIYWVYSKYDLFSSTSELFQQIFARS
                     FSINSKSVKILGQPWNDQLWNENDKYEVLGDIYGDNLPSFYKVFLYAPTWRSGRCTSFF
                     PFKDFSKNRLESFLEKYQLLICLRTHQLEANRVKDYVSCKRVLLLNEDRVTDIMSILNI
                     FDGLISDYSGIIFDYLLLDRPIILLPYDKEEYTSERSVNFNIDSFEFAPPPYNIDSFFS
                     LLQKAVCCKCISQKQLRFKNVVHYYIDNNSCQRHYEEIMKLIKMKNNKQVKKWI"
     CDS             5001..6314
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 203.9;
                     E-value: 5.2e-62)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg69_7"
                     /sec_met_domain="CTP_transf_like (E-value: 5.6e-16,
                     bitscore: 50.0, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 9.6e-119, bitscore:
                     386.6, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 4.2e-65, bitscore:
                     210.5, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDIEKKKTVYVGMSADIIHPGHLNIISEAQRLGKVTVGVLTDAAI
                     ASYKRLPYLNYEQRSLIVKNIKGVDEVIPQTTLDYVPNLKLLKPDFVVHGDDWKEGIQK
                     ETRQKVIDTIAKWGGKVIDIPYTKGISSTQLNEKLKEIGTTPEVRLKRLRRLIEAKSVV
                     RICESHSGLTGLIIENTVVEVNGVKREFDGMWSSSLTDSTSKGKPDIEAVDLTTRLHDL
                     NDALECTTKPIIFDGDTGGKIEHFVFTVRTLERLGVSAVIIEDKVGLKKNSLFGTDAVQ
                     LQDTIEGFSEKIKAGKLAQITTDFMIIARIESFIAGKGLEDAIERALAYVEAGADGIMI
                     HSKDKSGEDIKKFCYAFRQLNKSIPIVVVPTTYNHITETELASWGVNVIIYANHLLRSA
                     YPAMLNTAKIILANERSFEANDLCMSVREILELIPGTK"
     CDS             6324..7487
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 73.2;
                     E-value: 3.2e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg69_8"
                     /sec_met_domain="TPP_enzyme_N (E-value: 4.7e-15, bitscore:
                     46.5, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1e-21, bitscore:
                     68.3, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSPKFFVETLQTYSMDFFTGVPDSLLKNMCAYITDHIESQNNII
                     AVNEGTALGLAAGYYIATGCIPIVYMQNSGIGNTVNPLLSLTDKVVYNIPVLLLIGWRG
                     EPGIKDEPQHIKQGMITIPLLDTLGIKNQILNKDPNMAKSQINDAIEYMRMTKEAFAFV
                     IQKDTFEEYKLQNTEDSKFDLDREEAIKIVCNSLDKGSVIVSTTGMISRELFEYRESID
                     ANHETDFLTVGSMGHASQIALGIALRRKNKKVYCFDGDGAVLMHMGALTTIGTSRAVNY
                     IHIVFNNGAHDSVGGQPTVGLKVNLSKIASACGYNNVISVDSKATLKESLDRFKSINGP
                     VLLEVKVRKGARKDLGRPTLTPVKNKELLMNFLEEADESDKSDNVFK"
     CDS             7474..8595
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Fe-ADH"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg69_9"
                     /sec_met_domain="Fe-ADH (E-value: 3.3e-75, bitscore: 244.0,
                     seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCLNNDPFEYLQSNLSRYSSRKLFLVRGKKSYELCGAKRVVEDVI
                     SNLKCGFVEYFDFSENPKYEDLERGLKLLELSGADLIVAIGGGSVLDMAKLIRFFHSYS
                     GDILNEKFVKNRDLLPLFAIPTTAGTGSEVTHFAVLYKDNLKYSVSHKDMLPDRAIICP
                     QFTYKNARYLTACTGFDALSQAIEAYWNVYSIEESDNYSIKAIKLIWDNLPLVIDSSTN
                     ELRDKIAEGAYWAGKAINITKTTAPHAFSYPFTINYGYPHGHAVALTFPFFMRYNYAEL
                     ENKLHPLLNSKSHCKKMEQLYNMLGSTFDMIYDDMYNYLERIGLAINIRGRNFDKNLIL
                     HGINASRLSNNPCVLSQADVDFIVDEFVENGKL"
     CDS             8567..9409
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg69_10"
                     /sec_met_domain="Glycos_transf_2 (E-value: 2.7e-22,
                     bitscore: 70.4, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLLKMESCNMKLCVIMSIYKNDNLLAVTQSIESILRQAYEKIEF
                     YIQLDGEIRSDVLQYLRGLCIQDIRVKILNRTLNRGLAYSLNELLNIVLTKEYEYIARM
                     DADDISMPERFVKQIAFMNSHPDIDCLGTWAIEIDDDGKEYFRKKMPITHEECLELFKK
                     RDCMIHPTVMFRRSYFEKAGLYPEDTYFGEDTMMWAKGFKSGCKFANVPEYLFKFRLDS
                     NFFERRRGWKHAKSIYTLRHRVNRMLGFGWKEDCYALLYAMAKLMPKSILDIIYKTVR"
     CDS             9438..10661
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056:DegT/DnrJ/EryC1/StrS aminotransferase (Score:
                     269.2; E-value: 9.7e-82)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg69_11"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 6.4e-44,
                     bitscore: 141.5, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.2e-07, bitscore:
                     22.1, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIPFSPPYIDEAVINEVVDSLRSGWITSGPKVKALEEEIKSFSG
                     AKEVLCVNSWTSGAIMMLRWLGVKEGDEVIVPAYTYSATALAVLHAGAKPVMVDSGTDF
                     NISVEAVRKAITPKTKAIIPVDIAGFPCDYERIMALVQEPEMVKLFRSESPVQEKLGRI
                     LVMNDAAHSLGARYSSRQRTGCETDVAIFSLHAVKNVTTAEGGAICLNLPKPFDNTELY
                     KELRMTSLNCQTKDAFSKSKAGGWRYDIVGFGMKINMADVNAAIGLAQIREYPELLKER
                     KRVFNAYSDAFSACDWAIVPPSVDGEKESSYHIYALRIKDFTEEQRDRMIDEIAKSEVA
                     VNVHFIPMPMLSFFKSMGYDIKDYPQAYQNFKSEISLPIYPQLDSEKLNFIIETVKAAY
                     ATVITENR"
     CDS             10693..11280
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Bac_transf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1146:sugar transferase (Score: 222.7; E-value:
                     1.6e-67)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg69_12"
                     /sec_met_domain="Bac_transf (E-value: 8.8e-58, bitscore:
                     185.6, seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRFFDIVFSLLGILLLSPVFLLLYIAICLESKGGGFYKQLRVGR
                     YGGDFYVYKFRSMRVGADKKGLITVGGRDPRITRTGYLIRKYKLDELPQLFNVLKGDMS
                     LVGPRPEVRKYVDLYTDEQKKVLSVRPGITDYASIEYVDENMILGEASDPDRAYIEQIM
                     PDKIRYNMKYICNRSVKEYFKIIFLTFWSIIR"
     CDS             11646..12242
                     /gene_functions="other (smcogs) SMCOG1241:lipoprotein dsbF
                     (Score: 98.5; E-value: 6.1e-30)"
                     /gene_kind="other"
                     /locus_tag="ctg69_13"
                     /transl_table=11
                     /translation="MKKNFFYAGGLSLLLWGMAACSGQGKADKAAVVADSVVVKTDSVA
                     ADSTGYIVKVGESAPDFTITLTDGKQMKLSELRGKVVMLQFTASWCGVCRKEMPFIEKD
                     IWLKHKNNPEFALIGIDRDEPLDKVIAFGKSVGVTYPLGLDPGADIFAKYALRESGITR
                     NVLIDREGKIVKLTRLYNEEEFASLVDQIDEMLKK"
     CDS             12302..14167
                     /locus_tag="ctg69_14"
                     /transl_table=11
                     /translation="MAITIIILVLSAVFFMSGKVRSDLVALCALVLLILFNILTPEEAL
                     SGFSNSVVIMMVGLFVVGGAIFQTGLAKMISSRILKFAGTSELKLFILIILVTAAIGAF
                     VSNTGTVALMLPIVVSMAMSANINVSRLLMPLAFASSMGGMMTLIGTPPNLVIQNALIE
                     AGYERLSFFTFTPVGLVCVTVGLIVLIPLSKIFLTKKSDKEARGKRKNKSLQELAGEYQ
                     LSQNLYRVEVEESSGFVGKTIQELGIPQRYHVTILEVRRRSVLSRHFFKTKKQEMAEAG
                     TLIEAEDILYVLGEFENVKRFAGENRLSLLDTHKTEGSLHDTDEGFDFQEIGIAEILLL
                     PTANLINKPVKASGFRENYSINILGIQRKRDYLLKNLKDEKMHSGDILLVQGSWANIAR
                     LGEDQSQWVVLGQPLAEAAKVTLNHKAPVAALIMLGMIVTMMFDFIPVAPVTAVIVAAL
                     LMVLTGCFRNVEEAYKTINWESIVLIAGMLPMSLALEKTGASEVVSQSLVNGLGAYGPF
                     ALLAGIYFTTSLMTMFISNTATAVLLAPIALHSAVQLGLSPYPFLFAVTVAASMCFASP
                     FSTPPNALVMPAGRYTFMDYVKVGLPLQIIMGVVMVFVLPLLFPF"
     CDS             complement(14210..14944)
                     /locus_tag="ctg69_15"
                     /transl_table=11
                     /translation="MNTSLLPAEKDPMGAAIADFYHRQKADRLRVFSSQFDEDEIPVKQ
                     LFRKAGQMPLLERTALSMATGTILDVGAGSGCHALALQESGKEVSAIDISPLSVEVMKL
                     RGVKDARQVNLFDERFAATFDTILMLMNGSGIIGRLENMPLFFRKMKQLLRPDGCILMD
                     SSDLRYLFEDEDGSFLIDLAGDYYGEIDFRMQYKDIQGDPFDWLYIDFQTLSAYAADNG
                     FKAEMIKEGKHYDYLARLTVAL"
ORIGIN
        1 catcattgat ggttggggga gcagagagtt tacgaaagaa gagaaagaaa ttcttgaatt
       61 acttcgtagc ttagaagaaa attcgtatcc taatagtgaa atagattaga aattgaaaag
      121 aatcattaca tctcaatttt ttaaagattt tatgtctctt attactaata gaggattaga
      181 tagtttaatt gggattattg ttattcctta tttaatttta aaaataggag aagttgaata
      241 tgggagaatt gtattggcac aatcgatagt gtatttaggt gttgcctttg ttaattatgg
      301 attggatttt ttgatattaa agaaagtgcc gttatacatg tattttcaga aaatgcgtcc
      361 aatttcaatt tttatgtata gaattatatt attgagattt gctattttct tattgtatct
      421 tgttctttat tatattttac aatgtgtatt tgggttttca tctgaattga atctttattt
      481 ttctattttg tctctcattt gtcttgcaga agtgttttct gttagccatt tcttagtagt
      541 ctttcagaat gtaaaaatac ttccttgggt ttcggccttt agatttttat ttttattttt
      601 attcacttac atttttgtga gaaaagaaaa tgatgcatat agatatattt gtttttattc
      661 aatttcgtat ttgtttagta atcttgttgt tcttttttat actgtactca aatataaatt
      721 gcattatttt aaactaccta gtattggggc tcttaaaaaa atatttttta aatcatctcc
      781 tttttttatt agtaaattga atttgatttt atctgataaa ttgtataata ttctttgtgc
      841 tacttttgtc tctttgtctg ccgctgcttt actcgatatt tcttttaaag tattatctat
      901 tataattatt cctgtacaaa ttttgagtgt tgttatatta ggacggttct tcatgcgtac
      961 atctcaagaa gttattaaac gagtactttc ttttatattg ttttttagtt tatttctttt
     1021 tattattctg tttatagcta aaagatacat cttaacatat tattcattct ctttagtatc
     1081 tgatgtttta tggagcttta gtttagttct attttcatct ttatttgcta atttatcagt
     1141 ttttatagga gataatatta tgatctctaa ctcattggag aagcaattga taaaaagttc
     1201 tatatatagt tctttgtttg tatttccact actgattata acgctttgtt ttgtggataa
     1261 ttctttattt acactatctg tattcttttt gtttcataaa atattggaat ttctgttgag
     1321 agtatattat tcatggaatt atataaatta aaaaatagga ataatattat tcttttactg
     1381 aaaattcagt atctgaattt tgcattgtca atactactat ttatagtgaa tttgataagt
     1441 ggagctacaa ttaattacct tttcttttca tattatctgc tcttttcttt tttgtatata
     1501 actgttgtta gtttaaaagt attttcattg gctagtgctt ttaatctgtt tctttttgga
     1561 tattttatgt ttcaaatatc tgctttgttt gtgtcattag atacactttt agaaagaaaa
     1621 cttatggata atttgttcct tttttccgag gagcaaataa ataatacttt atgtgctaat
     1681 tctattattt tgaatgctat gtttttagga tgtttgatgt ctataattta tttaccaata
     1741 aaaacaaaca taaataaagc taatttgata tactctgaac gattacagaa ttggggatat
     1801 ttgctttttt gggctgcctt accatttact cttttgaaat tttatcttga aataaaatta
     1861 gttttaacag aaggatatta tgcatattat acttcatctt tatctatacc ctttctaatt
     1921 tcaatttcta ggtttatttt tgaaattggt ttttttcttt ttctaacatc tttaccgccg
     1981 aaaaaaaagt ttttaactgt atcaaaggtg tatatattag taatgtgttt attcttttta
     2041 attggagttc gaaatcgtgt aatcctttcg tttttatttg ttttatggtt ttattataga
     2101 ttttatagta aaaaatctcc taaaatattg tttttgttga ttatttcaat tagttctgtt
     2161 gcacttttgc ttttggtaca gttggttaga caagctggtg tttttctttt atcagatgac
     2221 agatctattt ttagttattt cttttatgca caatctacta atttttacat attaccactt
     2281 cttcagtatt atgacttaca cacagaagtt ccttttgttt ttgctccttt ctttaattta
     2341 gatactagtt attatgaccc aaatggaatt aataatttat taggaaatgc tattgctttt
     2401 cgtatctctc ctgatgaatt tagagaaggg catgggcttg gttcaagttt tatagcggaa
     2461 ttgtatgatc taggaattgt ttttatgtct attttatcta ttggtttagg ttttgtgatg
     2521 gggtggttcg agagaaatgt taaaaataat agagctcttc ttgctatttc attttatgct
     2581 atcacaaatt gtatatatat atcaagaagt agtcttttta gaaatgtata tatgtttcca
     2641 ttacttataa tattggtttt tattgcatta aaaataagat atccctttaa aatgaaaaaa
     2701 aatgaatatc ctacacgtct ctgatataga tgttagttca tgtgggggtg gaatgaatac
     2761 tgtcatccct gaacttatta tgcggcaact cttgtatgat agtacactta atgagacgct
     2821 gtttataacc cgaaaaaagt ataaaattgc aaaacagatt ccatacttta tttgcttcat
     2881 ggaagggaac tttcttaagt atttgcagaa atccgatttg ctggtatttc attctgtata
     2941 taatttaaaa tttatattac tctatttttt ttgcaagaag aataagctgc cttatttaat
     3001 tgttagtcat ggtggattat caaaagttgc attgaaaaaa ggaataataa aaaagaagct
     3061 atttaagttc ttgtttttga atcgttttgt aaaggatgct actgtgcttt gttttacatc
     3121 attagaggag caattaagtt ctgtatatac agataaaaaa tatataatag ttcctaaccc
     3181 aattcaaatt tcagattatt cttatcggtt agacgtgagc aataatgatg aagttaaaat
     3241 gatatttctt tcaaaaatag acttttatta taaagggctt gatgttttat ttgatgcatt
     3301 aaacataata aaagaagata tagttaatgc aaatgttttt ttatcctttt atggttatgg
     3361 taagaataaa gaagtagatg tcgaaaatat caatagtgcc gaaaaagata tattaaaatt
     3421 gattttacgt attaaagaat tgaatattgg tgaaagaata aaatattgtg gccctgtctt
     3481 tggacatcag aaaatggaag ttttgaagaa cagtgatatt tatgtattaa catctagatc
     3541 agaggctatg cctttaagta ttagtgaagc attatctgtt ggtactccat gtttggtaac
     3601 tcatggtact aatatgtcca atttgataga acagtataag gctggttggt cttcttcttt
     3661 aaataaagaa gatttggctt ttaatatttt aaaagctata aaggaatata aagattctcc
     3721 cgtcactttt cgtaagtcag caaggggact ttatgaatat aatagctcta ttgatgtagg
     3781 aaaggtatca atcgatcaat ataagactat attagaggaa aaataatgtt gtactatttt
     3841 cggattttta tttcatattt attatatgaa tttggagtta gaagaaaaga tataattatc
     3901 ttttctggtt ataaaaactt gaagtataat tttaattcta gatatttatt tgaatttttc
     3961 ttagaaaaaa aatcaaattt aaaatgtttt tttgttatag atgatgataa tttaagacgg
     4021 cgattgaatg aaatcgttgg tgattatttt gttacaacaa atagctggaa agatttaaaa
     4081 cttatctttt cagctggtac atggataact tctggaggat tgccaattag gataccatat
     4141 gtaaatagga atcgcgttgt tgtaaatttg tggcatgggc ttccttttaa aggaataggc
     4201 ttacttaaca atgaaaatac atgtttgcaa aacttgttga tctattgggt ttattcaaag
     4261 tatgacttat tttcttccac atcagaatta tttcaacaaa tatttgctcg tagtttttcg
     4321 attaattcta aatctgtaaa aatattgggg caaccttgga atgatcaatt gtggaatgaa
     4381 aatgataaat atgaggtttt aggtgatatt tatggagata atttaccatc tttttataag
     4441 gtgtttttgt atgcaccgac ttggagaagc ggacgttgta catctttctt tccatttaag
     4501 gatttttcaa aaaataggct ggaatctttt ctagaaaaat atcaattact aatttgtcta
     4561 aggacacatc agttggaagc taatagagta aaggattatg tttcgtgtaa aagggttctg
     4621 ttgcttaatg aagatagggt tactgatatt atgtcaatat tgaatatttt tgatggattg
     4681 atatctgatt actctggtat tatctttgat tatttgctat tggaccgccc aattatatta
     4741 cttccttatg ataaagaaga atatacttct gaacgtagtg tgaattttaa cattgattct
     4801 tttgagtttg cccctcctcc ttataacata gatagttttt tcagtttgtt gcaaaaagct
     4861 gtatgttgta aatgtatatc tcagaagcaa ttacgattca aaaatgtagt tcactattat
     4921 atagataata atagttgtca aagacattat gaagaaataa tgaaacttat aaaaatgaaa
     4981 aataacaaac aagtaaagaa atggatatag aaaagaagaa aactgtgtat gttgggatga
     5041 gtgctgacat tattcatcca ggtcacttaa atattatttc agaagcccag agattaggta
     5101 aggtaacggt cggagtttta acagatgctg cgatagctag ttacaaacga ttaccttatt
     5161 tgaattatga gcagcgctct ttaattgtta aaaatattaa gggagtggat gaggttatac
     5221 cacagacaac gcttgattac gtacctaact tgaaattgtt aaagcctgac tttgttgttc
     5281 atggcgatga ttggaaagaa ggtatacaaa aggaaactag gcaaaaagtt attgatacaa
     5341 ttgcaaaatg gggaggaaag gtcattgata ttccttatac taaaggaata tcttctactc
     5401 aacttaatga aaagctaaag gaaattggta caactcctga agttcgttta aagaggttga
     5461 gacgtcttat tgaagctaag tctgttgtac gtatttgtga atctcatagt gggctgacag
     5521 ggctgataat tgagaacaca gtcgttgagg taaatggagt aaaacgcgag ttcgatggta
     5581 tgtggtcaag tagtctgact gattctacat ctaagggtaa gcctgatata gaggctgtag
     5641 atttaactac tcgtcttcat gatctaaatg atgctttaga gtgtacaact aagcctatta
     5701 tatttgatgg cgatacgggg gggaaaatag agcattttgt attcactgtg cgtacattag
     5761 agcgtttagg tgtttcagct gttataatag aagataaagt tgggttgaag aaaaattcgt
     5821 tatttggtac tgatgctgtt caacttcaag atacaataga aggtttttct gagaagataa
     5881 aagctggaaa gctggctcaa ataactactg attttatgat cattgcacgc attgaaagtt
     5941 ttattgcggg taaagggctt gaggatgcta tagagagagc tttggcgtat gtagaagcag
     6001 gagcagatgg tataatgatt catagtaaag ataagtcagg ggaagatatt aaaaaatttt
     6061 gttatgcatt taggcaactg aataaatcta taccaattgt agtcgtgcct acaacttata
     6121 atcatattac ggaaacagaa ttggcttctt ggggagtaaa tgttattatt tatgctaatc
     6181 atctgcttcg gagtgcttat cctgcaatgc ttaatactgc taaaattatt ttggctaatg
     6241 aacgttcgtt tgaagcaaat gatttatgta tgtctgtaag ggaaatatta gaattaatac
     6301 ctggtactaa atagttggaa attatgttat cacctaagtt tttcgtagaa acgttgcaaa
     6361 catattctat ggattttttt actggagttc ctgactcttt attgaagaat atgtgtgctt
     6421 atattacaga tcatatagaa tctcaaaata atattattgc agtgaacgaa ggaactgcgc
     6481 ttggactagc tgccggatat tatattgcta cagggtgtat tcctattgtg tatatgcaaa
     6541 attcaggtat tggtaatacc gtaaaccctt tgttgtcttt gacggataaa gtcgtttata
     6601 acattcctgt attgttgttg atagggtggc gtggtgagcc tggtataaaa gatgaaccac
     6661 aacacattaa acaaggcatg attactattc ctcttttgga tactcttggt ataaagaatc
     6721 aaattcttaa taaagatcct aatatggcaa aaagtcaaat aaatgatgca atagaatata
     6781 tgagaatgac aaaagaggct ttcgcttttg tcattcaaaa agatactttt gaagaatata
     6841 agcttcaaaa tacagaggat agtaaatttg atttggatcg agaagaagca attaaaatag
     6901 tttgtaattc tttagataaa ggtagtgtta tagtttcaac tactgggatg atttctaggg
     6961 aattatttga ataccgggaa tctattgatg caaatcatga aacggatttt ttaacagtag
     7021 ggtcaatggg gcatgcatca cagatagctt taggtatagc tctccgaaga aagaacaaaa
     7081 aagtgtattg tttcgatggt gatggtgctg tacttatgca tatgggagca ttaactacca
     7141 taggaactag tagagctgtg aattatattc atatcgtgtt taataatggt gcgcatgact
     7201 ctgttggtgg gcaaccaaca gtgggattaa aggtcaatct ctctaaaatt gcttctgctt
     7261 gtggttataa taatgttata tctgtagata gtaaagctac tttaaaagaa agtttggata
     7321 ggtttaaaag tataaatgga cctgtattat tggaggtaaa agtgagaaaa ggggcaagaa
     7381 aagatttggg acgtcctact ttgactcctg ttaaaaataa ggaattatta atgaactttt
     7441 tagaagaagc agatgaatca gataaatcag ataatgtgtt taaataatga tccatttgaa
     7501 tatttacaga gtaatttatc tagatatagc tctcggaaat tattcctcgt taggggcaaa
     7561 aagtcttatg aattatgtgg agcaaaaaga gttgttgaag atgttatttc taatttaaag
     7621 tgtgggtttg ttgaatattt tgatttttca gaaaatccta agtatgagga tttggagaga
     7681 gggctgaaat tgctggaatt aagtggggcg gatttaatag tagccatagg tggtggaagt
     7741 gttttagata tggctaaatt aatccgcttt tttcattctt attcaggaga tatattaaat
     7801 gagaaatttg ttaaaaatag agatttatta cctttattcg caattccaac tacagcagga
     7861 actggtagtg aagtgactca ttttgctgtt ttatataagg ataatttgaa atattcggtt
     7921 tctcataagg atatgttgcc tgatagggct ataatttgtc ctcagtttac gtataaaaat
     7981 gcaagatatt tgacagcgtg taccggcttt gatgctttat cacaagctat tgaagcttat
     8041 tggaatgttt actcaattga agaatctgat aattactcta ttaaagctat aaagttaata
     8101 tgggataacc ttcctttagt gattgattcc tcaacaaatg aattaagaga taagatagca
     8161 gaaggtgctt attgggctgg taaggctatt aatataacaa aaacgacagc gcctcatgct
     8221 ttctcatatc cttttacgat aaactatggc taccctcatg gacatgcagt agcattaaca
     8281 tttccttttt ttatgagata taattatgca gaattagaaa ataagttgca tcctttattg
     8341 aatagtaaaa gtcattgtaa aaaaatggag caattatata acatgctggg atcaactttt
     8401 gatatgattt atgatgatat gtataattat ttagaaagaa taggcttagc tattaatatt
     8461 agaggaagga attttgataa aaatcttatt ttacatggta taaatgcttc tcgtttatct
     8521 aataatcctt gtgtattatc tcaagcagat gtagatttta tagtggatga atttgttgaa
     8581 aatggaaagt tgtaatatga agctctgtgt gattatgtct atttataaaa atgacaatct
     8641 gctagctgta actcagtcta tagaaagcat tttaaggcag gcttatgaaa aaatagaatt
     8701 ttacatacaa ttagatgggg aaatacgttc ggatgttctt caatatttac ggggactgtg
     8761 tattcaagat atacgggtaa aaatattaaa tcggacattg aataggggat tagcttattc
     8821 actaaatgaa ttattgaata tcgttcttac aaaagaatac gaatatattg ctcgtatgga
     8881 tgctgatgat atttccatgc cggaacgttt tgtgaagcag atcgcattta tgaattcaca
     8941 tccggatatt gattgccttg gtacttgggc aatagaaatt gatgatgacg gaaaagaata
     9001 ttttcgaaaa aaaatgccga taactcatga agaatgtttg gaactgttta aaaagcggga
     9061 ttgtatgatt catcctactg tgatgtttcg acgttcatat tttgagaaag ctggtttata
     9121 tcccgaagac acctactttg gagaagatac tatgatgtgg gctaaaggtt ttaaaagtgg
     9181 atgtaaattt gccaatgtac ccgaatatct gtttaagttt agattggatt caaacttctt
     9241 tgaaagaagg cgggggtgga aacatgcaaa atctatttat actttacgtc atcgtgttaa
     9301 tagaatgtta gggttcggat ggaaggaaga ttgttatgca ttgctatatg ctatggccaa
     9361 attaatgcct aaatctattc ttgacataat ctataaaaca gtacgttgat tttacttttc
     9421 ttataaaaca taaactcatg aaaatacctt tttcaccacc ttatattgac gaggcggtca
     9481 tcaacgaagt cgttgattcg ttacgttccg gttggatcac atccggtccg aaagtgaagg
     9541 ctttggagga agaaattaaa tctttctcag gagcaaaaga agtgctttgt gtcaattcct
     9601 ggacatcagg agctattatg atgttgcgtt ggctgggagt gaaggagggc gatgaagtga
     9661 ttgttcctgc ctatacttat agtgcaacgg cattggcagt gctccatgcc ggagccaaac
     9721 cggtaatggt ggattccgga actgatttta atatttcggt ggaggctgtt cgtaaagcta
     9781 ttactcctaa aacaaaggcg attatacccg tagatattgc tggttttccc tgcgattatg
     9841 aaagaatcat ggcactggtg caggaaccag aaatggtaaa actgttccgt tcggaatctc
     9901 ctgtgcaaga aaaattggga cgcatcttgg tgatgaatga tgctgcccac tctttgggag
     9961 cacgttacag tagccgtcag cgtaccggtt gtgaaactga tgtggctatc ttttcacttc
    10021 atgccgtgaa aaatgtgact actgccgaag gtggggccat ttgcctgaat ctgcctaagc
    10081 cgttcgataa tacggagttg tataaagagc tacggatgac aagcttgaac tgccagacca
    10141 aggatgcttt ttcgaaatct aaagccggag gatggcgtta tgatattgtc ggtttcggga
    10201 tgaaaatcaa tatggccgat gtaaatgccg ccataggact ggcacagata cgagaatatc
    10261 cggaattgct gaaagaacga aagcgggtgt ttaatgctta tagcgatgct ttttcggctt
    10321 gtgactgggc catcgttccg ccttctgtgg atggggaaaa ggaaagctct tatcacattt
    10381 atgctttgcg tattaaggac tttaccgaag aacaacgcga ccggatgatt gatgaaatcg
    10441 ctaaaagtga agtggctgtc aatgtgcact ttataccgat gccgatgttg tcgttcttca
    10501 aatcgatggg atatgatata aaggattatc cacaggctta tcagaacttt aagagcgaga
    10561 tatcattgcc gatatatccc caattggata gtgaaaaatt gaatttcatt attgaaactg
    10621 taaaggcggc ctatgcgacc gtaattacag aaaaccgata gtatatttac aaacactaaa
    10681 tagataagtt tcttgatccg tttttttgat atcgtttttt cccttttggg aattcttctg
    10741 ctttctcccg tttttcttct tctttatata gccatttgtc tcgaaagtaa aggaggtggt
    10801 ttctataaac agctccgtgt gggaaggtac ggaggggatt tttatgttta taaatttcgt
    10861 tcgatgcgtg taggggctga taaaaagggg ttgataacgg taggagggag agatccgaga
    10921 ataactcgta ccggatacct gatccggaag tataaattgg atgaattgcc tcagttgttt
    10981 aacgtactga aaggagatat gagtctggtg gggccccgtc ctgaggttcg taagtatgtg
    11041 gatttatata ccgatgaaca aaagaaagta ttgagtgtac gtccggggat tacggattat
    11101 gcttctattg agtatgtaga tgaaaatatg attcttggag aggcttcgga tcctgacaga
    11161 gcatatatag aacagattat gcccgataag atacggtata atatgaaata tatctgtaat
    11221 cgttcggtga aggaatattt taaaattata tttctgacat tttggagcat cattcgttag
    11281 gtatgttttt aaggaaactg ggggaagttc ttctttttgt tttcgtaccc tattatgtga
    11341 gaaagaataa ggagtagacg gaagtttcga agagaagtta attcaataaa aaagaaagga
    11401 tcggcaattg ccgatccttt cttttttatt gagcctcttg tcggattcga accaacgacc
    11461 ccgagattac aaatcacgtg ctctggccaa ctgagctaaa gaggcgtcat ttctgttttg
    11521 cgggtgcaaa ggtaggaaaa acttttaaac ttgcaaatac tttgaaaaaa aatgcttcat
    11581 aaaaatagtg tttgataagt cggattcttt gtttactttt gcaaatcaat taattatagg
    11641 aaagtatgaa gaaaaacttt ttttatgcag gtggtctgtc attgcttctt tggggtatgg
    11701 cagcatgttc cggacaagga aaagcggata aagcagctgt tgttgcggat agtgtagtgg
    11761 tgaaaacgga tagtgttgcg gcagacagca caggatatat tgtgaaagtg ggagagtcag
    11821 ctcccgattt taccattact ctgaccgacg gaaagcagat gaaactctcc gaacttcgcg
    11881 gtaaagtggt gatgttgcag ttcacagcca gctggtgcgg agtatgccgt aaagagatgc
    11941 cttttataga gaaagatatc tggctgaagc ataaaaacaa tcctgagttt gctttgatag
    12001 gcattgaccg tgacgaacct ctcgataagg tgatcgcatt tggaaagtcg gtaggggtga
    12061 cgtatccgtt gggattggat ccgggagcgg atatctttgc gaagtatgca ttgcgtgaat
    12121 cgggcatcac ccggaatgtc ctgatagacc gggagggtaa gattgtgaag ctgactcgtt
    12181 tatataacga agaggagttt gcctcactgg tggatcaaat agatgaaatg ctgaaaaaat
    12241 aagttgaaca agcaggggtg attttctgtt tttaacatag atcaccccat ctttttattt
    12301 tatggctata acgattatca ttctcgtact gtcggctgtc ttttttatga gtggaaaggt
    12361 acgttccgac ttagtggcgt tgtgtgcgct ggtattatta atccttttca atatcctcac
    12421 tccggaggag gcgctttcag gattttctaa ttctgttgtt attatgatgg tcggcctgtt
    12481 tgttgtaggt ggtgccatct ttcagacggg gctggcaaag atgatcagca gccgtatcct
    12541 gaaatttgcc gggacaagcg aactaaaact ttttatcctg attatattgg tgacggctgc
    12601 catcggcgct tttgtcagca atacgggaac ggtggcgttg atgctgccta ttgtggtcag
    12661 tatggccatg agtgccaata tcaatgtaag ccgtttgctg atgcctcttg cttttgccag
    12721 tagtatgggt gggatgatga cattgattgg tacaccgccc aaccttgtga tacaaaatgc
    12781 cttgattgaa gccggctatg aacgtctctc tttcttcact tttactcctg taggcttggt
    12841 gtgtgtcact gtcgggctga ttgtgctgat tccgctgagt aagatcttcc tgacgaagaa
    12901 aagtgataaa gaggcacggg gaaagcgcaa gaataagtcg cttcaggagt tggcgggtga
    12961 ataccagtta tcacagaacc tttatcgggt ggaggttgaa gagtcttccg gttttgtagg
    13021 taagaccata caggagctag ggattccgca gaggtatcat gtgacgattt tggaggttcg
    13081 ccgccgttcg gttttgtccc ggcacttctt caagacaaaa aagcaggaga tggcagaagc
    13141 cggaaccctg attgaggcgg aagatattct ttatgtatta ggagaatttg aaaatgtgaa
    13201 acgctttgca ggtgagaacc gtctgtcttt attggataca cataagaccg aggggagtct
    13261 gcatgatacg gacgagggat tcgattttca ggagataggc attgctgaaa ttctgttact
    13321 gcctaccgcc aatctgataa acaaaccggt gaaagcttcc ggattcaggg agaattatag
    13381 catcaatata ttgggtattc agcgtaaacg tgactatctg ctgaagaatc tgaaggatga
    13441 aaagatgcat tcgggagata tcttgctggt gcagggaagt tgggcaaaca tagccaggct
    13501 tggtgaggat cagtcgcagt gggtcgttct ggggcagccg ttggctgaag cggccaaagt
    13561 aaccctgaat cataaagcac cggtagcggc actgatcatg ttgggtatga ttgtaaccat
    13621 gatgtttgac tttattccgg tggctcctgt gacggccgta attgtagcgg cactgctgat
    13681 ggtactgacc ggatgtttcc gcaatgtgga agaagcttat aaaacaatca actgggagag
    13741 tattgtgctg atagcaggta tgctgcccat gtcattggca ttggagaaaa ccggagcttc
    13801 ggaggtggta tcgcaatcgt tggtgaatgg actgggagct tatggccctt ttgctttgtt
    13861 ggcaggtatt tacttcacaa cttcgctgat gacaatgttt atcagcaata cggccactgc
    13921 tgtgttgctt gctcctatcg ctcttcactc ggccgtacag ttggggctga gcccttatcc
    13981 gttcctgttt gccgtgacag tggcggcaag tatgtgtttt gcttcacctt tctccacgcc
    14041 gcctaatgcg ttggtgatgc cggcaggacg ctatacgttt atggattacg taaaagtagg
    14101 tctgccgctt cagatcatta tgggcgtggt aatggtgttc gtattgccgc tactgtttcc
    14161 gttttagtct tttagggagg gacggtttat tgaaaacatt ccctcctgtt tataaggcaa
    14221 cagtcagccg ggccagatag tcatagtgct taccctcttt tatcatttcg gccttgaagc
    14281 cattgtcggc agcataggcg ctgagggtct ggaagtcgat atacagccag tcgaaaggat
    14341 cgccttgaat atctttatat tgcatgcgga agtcgatttc tccataataa tctcctgcca
    14401 ggtcgatcag gaagctgccg tcttcatctt cgaacagata gcggaggtca ctcgaatcca
    14461 tcaggatgca accatccggg cggagtaatt gtttcatctt gcggaagaag agaggcatat
    14521 tctccaaacg tccgataatg ccggaaccgt tcatcaacat aaggatggta tcgaaagtcg
    14581 cggcaaagcg ttcgtcgaac agattgactt ggcgggcatc tttcactccc cgcagtttca
    14641 tcacttcgac ggataaaggg gagatgtcga tggcggaaac ttctttaccg ctctcttgaa
    14701 gggcaagagc gtggcaaccg cttccggcac ctacgtcgag tattgttccg gtagccattg
    14761 agagggctgt gcgttcgagt agaggcattt gtccggcttt gcggaaaagt tgcttgacgg
    14821 gtatttcgtc ttcatcgaac tgagaagaaa atacgcgtaa tctgtctgct ttttggcgat
    14881 gataaaaatc ggctatggca gcacccatcg ggtctttttc tgccgggagc agggatgtat
    14941 tcattgattg gtttttagtt gttacagcgg gcaaagatag ggaattcaca gaaaaagagt
    15001 atctttgtcc acggaaaata tagaataaga aaggaaagat tatgagctta gaagatgcga
    15061 ttatgggtgg aattgtcttt aaaggaaaga aagaaggccc gaagaaagat gaaaataaag
    15121 tgaaaacaaa agcgaagaaa acaacctata taaagggaac tcacggttcc ggagctgcca
    15181 agatgaaagc tgagatccgg agaaagaggg cgaacagaca taaacggtaa ataacgaata
    15241 acgatgaacg ataaactcac tgcgatatca acgcacagcc tgtttatcgt tcatcgttat
    15301 tcgttttaaa gtcgttccgg taatatttca atccagtagt catccggatc attgatgaaa
    15361 tagagcccca tggaagtatt ctcaaagcat acgcagtcca tttctttgtg atattggcgt
    15421 acggcatcat aatctcccgc tacacggaag caaagatggc tttcgttctc tcccaattca
    15481 taggcttcgg tatggtctcg cagccaggtg agttccaata aaaaaccggt ggtgttatct
    15541 gtgagatata ccaggataaa agagccgtcg gctgcctctt tccggtgatg ttctttcaat
    15601 cccaatgctt tttcgtagaa agcaatgcta cgttccagat cagtcacatt gatattgaag
    15661 t
//
