LOCUS       c00286_gnlPro..        14010 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CBAIGPDD_286.
ACCESSION   c00286_gnlPro..
VERSION     c00286_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 23:54:13
            Original ID  :: gnl|Prokka|CBAIGPDD_286
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14010
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14010
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2:4010](-)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      complement(3..4010)
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14010
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14010
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             complement(3..4010)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg286_1"
                     /sec_met_domain="HGD-D (E-value: 1.6e-28, bitscore: 91.0,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 3.7e-35, bitscore:
                     112.4, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKIGIDVGSTTAKLVAVDENDNLLFSKYERHNAKAKETILSFLK
                     ELLSEIGDKDISVRITGSIGMGISEKCSLPFVQEVVAAAKAIQKDYSHVTSMIDIGGED
                     AKVVFFKDAEATDLRMNGNCAGGTGAFIDQMAIILGVNIDELNQLAMNATQVYPIASRC
                     GVFCKTDIQNLIAKNVSRENIAASIFRAVAVQTVVTLAHGCDITTPVLFCGGPLTFIPA
                     LRKAFIDYLSLDEKEIILPANGTLLPALGAALFHLDKEDYCKLSHLIDKIDTTLNGNGN
                     LASTGLEPVFASNEEYEAWKERISRHKMISSGLKAGTQDVFIGIDSGSTTTKIVVLDED
                     SRLLYSYYNINGGNPIKAVEEGLNQLNDECLKQNAVLNIKGSCSTGYGEDLIRSAFQLH
                     SGIIETIAHYMAAHYLNKDVSFILDIGGQDMKAIFVNNGVIDRMEINEACSSGCGSFLE
                     TFAKSLGYSAQEFSLAACHSEAPCDLGTRCTVFMNSKVKQVLREGATINDIAAGLAYSV
                     VKNCLYKVLKLKDISVLGKDIVVQGGTMRNDAVVRAIELLSGAEVARCDTPELMGAFGC
                     ALYAMKHQGESVSLDEIINKAQYSARSLYCKGCDNRCLVIRYEFESGKSYYSGNRCEKV
                     FTNGESSNRKGLNVYRQKEELLFHRSAEIAAPEQIIGIPRCLNMYEEYPFWHTLFTSCG
                     IQVCLSDPSNFRKYEHNARMVMSDNICFPAKLVHSHVQDLIEKKVDRIFMPFVIFERKG
                     MEQNSYNCPIVTGYSEVIKSVQSEGISVDSPAITFKDRNLLFKQCREYLSGLSVDDRTI
                     QQAFQKAESEQHSFINTLVDYNKNILQQTGKGETLTVMLAGRPYHTDSLIQHKVSDMLS
                     DMGVNVITDDLVRQMDIPTGDAHFVAQWAYTNRILKAAKWCATQGKNIQFVEMTSFGCG
                     PDAFLVDEVRDLLMRHNKSLTLLKLDDINNIGSMKLRVRSMIESLKLANADGTEGDVKD
                     FTTVPVYDKSYRDRKILVPYFTPFISPLIPAIMKVAGYDAENLPLSDNDSSEWGLKYAN
                     NEVCYPATLIVGDIIKALKSGKYDISKIAVAITQTGGQCRASNYISLIKKALVDAGYTD
                     IPVISISVGSDIDNDQPAFKVNWMKVVPITFHAVLYSDCIAKFYYASVVREKEAGASAK
                     LRDKYLQLAPEVILRRNIKGLNSLLQSAITEFNEVCRAVDTPKVGIVGEIFLKFNPFAQ
                     KEIIDWLIGRKIEVVPPILADFFMQGFVNRKVNTDSYIKNRQLPEFIYDWIYKFVKKQI
                     DKINETASKFRYFAPFNDIFEEAEGAKSVISLNAQFGEGWLLPAEIVSYARQ"
     CDS             complement(4130..7417)
                     /locus_tag="ctg286_2"
                     /transl_table=11
                     /translation="MKKIIISLALVLTALSSYAITPLWMRDARISPDGKEIVFCYKGDI
                     YKVPVQGGTATQLTTQASYEANPVWSPDGKQIAFASDRNGNFDLFIMPADGGTARRLTY
                     HSASEIPSAFTPDGKFVLFSASIQDPAQSALFPTGAMTELYKVPVTGGRTEQVLATPAE
                     WVCFDKSGKNFLYQDRKGFEDEWRKHHTSSITRDVWLYDASTGKHTNLTNREGEDRNPV
                     YAPDGNSVYFLSERNGGSFNVYNFALNTPQEVKAITTFRTHPVRFLSISDKGTLCYTYD
                     GELYTQEPNARPKKVNVDLVRDDEKEIATLRFSQGATSASVSPDGKQVAFIVRGDVFVT
                     STDYATTKQITNTPAKEAGVSFAPDNRTLVYASERTGNWQLYTAKIARKEEANFPNATL
                     IEEEVLLPSKTIERAYPQYSPDGKELAFIEDRNRLMVLNLKTKKVRQVTDGSTWYNTGG
                     GFDYEWSPDGKWFTLEFIGNRHDPYSDIGIVSAQGGTITNLTNSGYISGSPRWVLDGNA
                     ILFQTERYGMRAHASWGSQQDVMLVFLNQDAYDRYRLSKEDFELLKEFEKEQKKAKEKD
                     GDKKKDGSKSKKEKADKEGDKEDTEEDKADKKDIVVELSGIEDRIVRLTPNSSDLGSAI
                     LSKDGENLYYFSAFEEGYDLWKINLREKDTKRLHKLNSGWSSLMLDKKGDIFLLGSRNM
                     QKMDAKSDALKSISYQAEMKMDLAAEREAMFDHVYKQHQKRFYNLNMHGVDWDAMTAAY
                     RKFLPHIDNNYDFAELLSEWLGELNVSHTGGRYSPRGNGDVTSNLGLLFDWNYLGKGMQ
                     IAEIVEKGPFDHSRTKVKAGCIIEKINGEEITPDKDITDLLNNKAGKKTLVSLYNPQNK
                     ERWEEVVKPVTSGQLNGLLYKRWVKQRAEDVEKWSGGRLGYVHIQSMGDGSFRTVYSDI
                     LGKYNNCDGIVIDTRFNGGGRLHEDIEILFSGQKYFTQVVRGREACDMPSRRWNKPSIM
                     LQCEANYSNAHGTPWVYKHQNIGKLVGMPVPGTMTSVSWETLQDPSLVFGIPIIGYRLP
                     DGSYLENTQLEPDIKVANSPETVVKGEDTQLKMAVDELLKEIDSRKK"
     CDS             complement(7485..8411)
                     /locus_tag="ctg286_3"
                     /transl_table=11
                     /translation="MNFKDCIDSYPFILMEGALGERLKREFDLDISGTVAMADLVYQQK
                     GRLALETLWNEYIDIAYRYQLPFLATTPTRRANKERIYMAGYNESIIADNVDFLRSIKE
                     AANVDMYIGGLMGCKGDAYTGEEALNLEEAIDFHSWQAGLFKSAKVDFLYAGIMPVLTE
                     AIGMAVAMSDTDIPYIISFTIQRDGKLIDGHTIDDAIHCIDNHVSNKPVCYMTNCVHPD
                     IVYEALSHKFNQTQTVKSRFWGIQANTSQLSYKELDGANHLHTSSAADLSEAILKLKSD
                     CHLKIFGGCCGTDSSHMEKIAKISEVT"
     CDS             complement(8454..9275)
                     /locus_tag="ctg286_4"
                     /transl_table=11
                     /translation="MNYKITTLVENCVYGRKLQAEHGLSLYIETPENRLLFDTGASDLF
                     IRNARLLNIDLQKVDYLVLSHGHSDHTGGLRHFLELNAEATVVCKREVFFPKFKDEREN
                     GMKYTRSLDLSRFRFIDELTELVPGVFLFPSVDIIDRKDTHFERFWIQKEDGSRVPDTF
                     PDELAMVLVEPEGLSILSACSHRGITNILRTVRTAFPELPCNLLLGGFHVHNAEESKYQ
                     VIADYLHEYLPQKIGVCHCTGVDKYAFFYKDFGDRIFYNHTGKLIQTDSLL"
     CDS             9489..10034
                     /locus_tag="ctg286_5"
                     /transl_table=11
                     /translation="MEKEAKGKVNTVQIQYYQSPCGKLILGSFENKLCMCDWVVSEERR
                     ATIDKRIQKALNAQYAIENSEVITQTISQLDEYFSRQRTTFDIPLLLVGTEFQKSVWNE
                     LLNIPYGTTISYAQLSQRLDNPKAIRAVASSNGANSISILIPCHRVIGSDHKLTGYAGG
                     LVAKKTLLELESNERRLL"
     CDS             complement(10230..10769)
                     /locus_tag="ctg286_6"
                     /transl_table=11
                     /translation="MAKKVLIISSSPRKGGNSDMLCDEFMKGVLETGNEVEKIFLKEKA
                     IHPCTGCSVCSMYGKPCPQKDDAAGIVEKMIAADVIVMATPVYFYTMCGQMKIMIDRCC
                     ARYTEITNKEFYFIIAAAENDKGMMERTIDGFRGFLDCLENPQEKGVIYGIGAWKVGEI
                     KDTPYMQEAYEMGKMV"
     CDS             11036..11725
                     /locus_tag="ctg286_7"
                     /transl_table=11
                     /translation="MKKIQLTNAHKEKLFQIPLFRDLPLNIKESLLDKLDFVIYAADKK
                     EIVVTQGTPCNKLYVLLEGKLRTDIIDGLGNEVMIEYIIAPRTFATPHLFNSNNTLPAT
                     FTALEDSVVLMATKDSTFKVISQDPQVLHNFLCIAGNCNICTVSRLKPLSRKTVRERFI
                     VYLFEHKKKDSLTVEIMHTQSQLAEYLNVSRPALSKEINKIIKEGLITMEGKKIEILNK
                     MALEKYL"
     CDS             complement(11815..13101)
                     /locus_tag="ctg286_8"
                     /transl_table=11
                     /translation="MKTFYWSFVLMLLPSMAYTQTTEKENEFSMSMQIRPRAEYRNGAL
                     VPRNEGQKAASFINNRARLSLDYKRSDLEIKMSAQHVGVWGQDPQIDKNGRFILNEAWA
                     KLDFGKGFFAQLGRQTLIYDDERILGGLDWNVAGRYHDALKLGYANKNNEIHAILAFNQ
                     NDEKTAGGTYYNSSIGQPYKNMQTVWYHYKADKIPFGASLLFMNLGLETGNQLTQDSHT
                     RYLQTMGTYLTYKNSGWNLDGAFYYQTGKNKDAESVSAFMASATAAYAFNKTWGMVVSF
                     DYLSGNEEGSSKFKAFDPLYGTHHKFYGSMDYFYASAFNKGFAPGLIDGRLGARFRASA
                     KVDMELNYHYFATATEVDFKEDLKKSLGSEVDYQINWSVMKDVKLSAGYSFMLGTKTMD
                     AVKGGNHKSWQDWGWVSVNINPKVFFTKW"
     CDS             complement(13109..13552)
                     /locus_tag="ctg286_9"
                     /transl_table=11
                     /translation="MPALQSPWFAPHVIVYMFAYAMLGAAVVMAVYLLWFKKKDIERKE
                     MDLCDNLTYVGLAFMTLGMLTGAIWAKEAWGHYWAWDPKETWAAATWFSYLVYIHFRLG
                     RPLKSRPALVILLVSFVLLQMCWYGINYLPSAQGVSVHTYNLN"
     CDS             complement(13638..13880)
                     /locus_tag="ctg286_10"
                     /transl_table=11
                     /translation="MVCDSRIDLLELGRVCCLERKEAGMDLWIYLVGAGHLFQFYPRYV
                     DFSGTSSDADDGRDTSVVFFLPSIGWFDNVRALEI"
ORIGIN
        1 ccttgccggg cgtaagacac gatttcagcc ggcaacaacc agccttcacc gaattgggca
       61 ttcagcgaaa taacgctttt agctccttcc gcttcttcaa agatatcatt gaagggggca
      121 aagtaacgga acttacttgc tgtctcattt attttatcaa tctgtttctt tacaaacttg
      181 tagatccagt cgtaaataaa ctcaggcaac tgtctgtttt ttatgtaaga atccgtattg
      241 actttcctgt tcacaaaccc ctgcatgaaa aagtcagcca gaatcggcgg aaccacttct
      301 atcttgcggc ctatcagcca atcaatgatc tctttttgtg cgaaaggatt gaatttcaag
      361 aagatttctc ctacaattcc gactttagga gtatctacag ccctacacac ctcattaaat
      421 tcagtgattg ccgattgcaa caaagagttc aaccccttta tgtttcttct cagtatcact
      481 tcaggtgcca gttgcaggta tttatcacgc agctttgccg atgcacctgc ttctttctca
      541 cgtaccacag acgcataata aaacttagca atgcaatcac tatacaaaac ggcatgaaaa
      601 gttatcggta ctactttcat ccagttgacc ttgaacgcgg gctggtcatt atctatgtca
      661 ctgcccacag agatagagat taccggaata tccgtatatc cggcatccac caacgccttt
      721 tttatcaagg aaatatagtt gctggcacgg cattgtcctc ccgtttgggt gatggctacg
      781 gctatttttg aaatatcata tttcccgctt ttaagtgctt ttataatatc gccgactatc
      841 agagtagccg gataacagac ctcattattc gcatacttca gcccccattc acttgaatca
      901 ttatcactga gaggaaggtt ttccgcatca taaccggcta ctttcataat agcaggaatc
      961 aaaggtgaaa tgaacggagt aaagtaagga accagtatct tacggtcacg gtaagacttg
     1021 tcatagacag gaacggtcgt aaagtccttt acatcgcctt ccgttccatc cgcattcgca
     1081 agtttgaggc tttcaatcat ggaacgtact ctcaacttca ttgaaccgat attattgata
     1141 tcatccagtt tcaataaagt cagcgatttg ttatgacgca tcagcaaatc ccttacttca
     1201 tccaccagaa aagcatccgg tccacatccg aacgaagtca tctctacaaa ctgaatattc
     1261 tttccttgtg tcgcacacca tttcgcagcc ttcaggatac ggttcgtata cgcccattga
     1321 gcaacaaaat gcgcatcacc cgtcggtata tccatctgac gcaccaaatc atccgttatc
     1381 acattcactc ccatatccga aagcatatcc gagactttgt gctgtatcag agaatcggta
     1441 tgataaggac gtccggcaag catgacagtc agagtctctc cctttccagt ctgctgcaat
     1501 atgtttttgt tataatcgac caatgtatta ataaaagagt gctgttcgct ttccgctttt
     1561 tggaatgctt gctgaatcgt ccgatcgtcc acgctcaaac cgctcagata ttcacggcat
     1621 tgtttaaaca acagattccg gtctttgaaa gttattgcag gggaatcaac cgatatacct
     1681 tcggactgca cacttttgat aacctccgaa taacctgtca caatcggaca attataactg
     1741 ttttgttcca tcccttttct ttcgaaaata acaaaaggca taaaaatccg gtcgaccttc
     1801 ttttctatca agtcctgaac atgactatgt accagcttag ccggaaagca gatattgtcc
     1861 gacatcacca tacgcgcatt gtgctcatac tttctgaaat tggacggatc agacaaacag
     1921 acttgtatgc cacaggaagt gaaaagagtg tgccagaatg gatattcctc gtacatattc
     1981 agacatcggg ggattccgat aatctgctcg ggtgctgcaa tctctgcgct gcgatgaaac
     2041 aaaagctctt ctttttgccg atagacattc agacctttcc ggttactgct ctctccattc
     2101 gtgaaaactt tctcgcacct gtttcccgaa tagtaacttt tgccgctttc gaactcgtaa
     2161 cgaatgacca gacaacgatt atcgcaaccc ttgcaatata aagaacgtgc cgaatattga
     2221 gctttattga taatctcatc caatgatacg gactccccct gatgtttcat cgcatataat
     2281 gcacatccga atgctcccat caattcgggt gtatcacacc ttgccacttc cgctcccgag
     2341 agaagttcaa tggcacggac caccgcatca ttgcgcatgg tgcctccctg cacaacaata
     2401 tcttttccca aaacagatat atctttcagt ttcagcacct tatacaggca attcttgaca
     2461 acggaatatg ccagtccggc ggcaatatca ttgatcgttg ccccctccct gagtacctgt
     2521 ttcacttttg agttcataaa aacggtgcac cttgttccca aatcacacgg tgcttccgaa
     2581 tggcaggctg ccagagaaaa ctcttgtgcc gaatacccca gagatttagc aaacgtttca
     2641 agaaaagaac cacatccgga agagcatgct tcattaatct ccatccggtc aatcacacca
     2701 ttattcacaa aaatagcctt catatcctgt ccgccgatat cgaggataaa agacacatcc
     2761 ttgttcagat aatgcgctgc catataatgg gcgatcgttt cgataatccc cgaatgaagc
     2821 tgaaaggcag acctgataag gtcttcccca tatccggtag aacagcttcc ttttatattg
     2881 agtacggcat tctgcttcaa acattcatcg ttcaactgat tcagcccctc ttccacagct
     2941 tttatcggat tgccgccatt aatattataa taagaataca gaagccttga atcttcatcc
     3001 agtacaacaa tctttgtcgt agtagaacct gaatcgatgc cgataaagac atcctgtgtt
     3061 ccggctttca agccggaaga tatcatctta tgacgggata ttctttcttt ccatgcttca
     3121 tattcttcat tacttgcaaa aacaggttcc aaccctgttg aagcaaggtt accgttaccg
     3181 tttaaagtag tgtcaatctt atcgatcaaa tgggacagtt tacagtaatc ctctttatca
     3241 agatgaaata gagcagcacc tagtgcaggg agcaaagtgc cgttggccgg cagtatgatc
     3301 tctttttcat cgagggacaa ataatcaatg aaggctttcc gcagtgccgg aatgaaggtt
     3361 aacggaccac cgcaaaacaa tacgggagtt gtaatatcgc aaccgtgcgc cagcgtcact
     3421 accgtttgaa ctgctaccgc acgaaagatg gaagccgcaa tattctcacg acttacattt
     3481 ttagctatca gattctgaat atccgtttta cagaaaacgc cacaacggga ggcaatagga
     3541 tatacctgtg tcgcattcat ggcaagttga ttcaattcat caatattcac tcccagtata
     3601 atcgccatct ggtcaataaa agcgcccgtc cctcctgcgc aattgccgtt catacgcaaa
     3661 tcggtcgctt cggcatcctt aaagaagacg actttcgcat cttctcctcc gatgtctatc
     3721 atagaagtca catgagaata atccttttgt atcgctttcg ctgccgcaac aacctcctgt
     3781 acaaacggca acgaacattt ctctgaaatt cccattccga tagagcctgt tatcctcacg
     3841 gaaatatctt tatctccgat ttcagataac agctctttca agaatgatag aattgtctct
     3901 tttgctttcg cattgtgtct ctcgtacttt gaaaataata gattatcatt ttcatcgacg
     3961 gcaactaact tcgccgtcgt tgaacctaca tcaattccta ttttaatcat gttctacact
     4021 atgttcccct tagtttgaca ctattgtcaa acacaaaagt aagaataagt tggacacatc
     4081 atttcaataa gctctttttt tcggttcttt taacacaaac aaacgatgtc tatttcttcc
     4141 ggctatctat ttctttaagc aattcatcta cagccatttt gagttgcgtg tcctctcctt
     4201 tcactaccgt ctccgggctg ttggcaactt tgatatcagg ttccagctga gtattttcca
     4261 gataactgcc atccggtagg cgatagccga tgataggaat cccaaatact aatgaagggt
     4321 cctgcaaagt ttcccaagat acacttgtca tagttcccgg gacaggcata cctaccagtt
     4381 ttccaatgtt ctgatgcttg tacacccacg gagtgccatg cgcattcgaa taattggctt
     4441 cacactgcaa cataatagaa ggcttgttcc agcgacgact tggcatatca caggcttcac
     4501 gtccgcgtac cacctgagtg aaatatttct gaccactgaa aagaatttca atatcttcat
     4561 gcagacgacc gcctccgtta aaacgggtat cgatcacaat tccgtcacag ttattgtatt
     4621 ttcccagaat atccgagtaa acagtacgga aactgccatc tcccatagat tgaatatgaa
     4681 cgtatcccaa acgaccgccg gaccatttct ccacatcctc agcacgttgt ttcacccaac
     4741 gtttatataa taagccatta agctgtccgc ttgtgacagg ttttaccact tcttcccaac
     4801 gttccttatt ctgtgggttg tacagcgaaa ccagtgtttt tttccctgcc ttattattca
     4861 aaagatcagt gatgtcctta tccggagtta tttcttcccc gttgattttt tctataatgc
     4921 accctgcctt tactttggta cgggaatgat cgaacgggcc tttctctacg atttcagcaa
     4981 tctgcatacc ttttcccaga taattccagt caaacaataa gcccagatta gaggttacat
     5041 ccccattgcc cctcggagaa tagcgccctc cggtatgcga aacattcagt tcacctaacc
     5101 attcgctcag taattctgca aaatcatagt tattatcaat atgcggcaga aatttacgat
     5161 aggcagctgt catggcatcc cagtccactc cgtgcatatt aagattgtag aaacgttttt
     5221 gatgttgttt atatacatga tcgaacattg cctcacgttc ggctgccaaa tccattttca
     5281 tttcagcctg ataactgata gatttcagag catctgactt tgcgtccatt ttctgcatat
     5341 ttctgcttcc cagcaagaag atatctcctt ttttatccag catcagtgat gaccagccgg
     5401 aattaagttt atggagacgc ttcgtatctt tttcacgaag atttattttc caaaggtcat
     5461 acccctcttc gaaagctgag aagtaataca gattttctcc atcttttgaa agaatggcac
     5521 tacctaaatc agaagagtta ggagtcaggc gtacaatacg gtcctcaata ccgctgagtt
     5581 ccacaacaat atctttcttg tctgccttgt cttcttcggt atcctcctta tctccttctt
     5641 tgtctgcctt ttccttttta gacttacttc cgtccttttt cttatcaccg tctttctcct
     5701 ttgctttctt ctgctccttt tcaaattctt tgagcagttc gaaatcctct ttactcaaac
     5761 gataacggtc gtaagcatcc tgattcaaga ataccagcat cacatcctgt tgtgatcccc
     5821 aggaagcatg cgcacgcata ccataacgtt cggtctgaaa cagaatggca ttcccatcca
     5881 gcacccaacg tggagagccg ctaatataac cgctgttagt cagattagtg atagtacctc
     5941 cctgcgcgct gacaatgccg atatccgaat agggatcatg acgattgccg ataaactcaa
     6001 gcgtaaacca cttgccatcg ggcgaccatt cgtagtcgaa tccgcctcct gtattgtacc
     6061 atgtagaacc gtctgtcacc tgacgtactt ttttggtttt cagattgagt accatcaacc
     6121 ggttacggtc ttcgataaaa gccagttcct taccatccgg agagtattgc gggtaagcac
     6181 gttctatggt tttggaggga agcaatactt cttcttcaat gagagtggcg ttagggaaat
     6241 tcgcctcttc tttacgagct atcttagcag tataaagttg ccagttgccg gtccgctcgc
     6301 tggcgtaaac cagtgtacgg ttgtcgggag caaaagatac accggcttcc tttgccggag
     6361 tatttgttat ttgcttggtc gtagcataat cggttgaagt cacaaaaaca tcacctcgca
     6421 caataaaagc cacctgctta ccatccggag acacagaagc ggaagtcgca ccctgagaaa
     6481 atctgagagt ggcaatctct ttttcatcat cacgcacaag atcaacattt actttctttg
     6541 ggcgggcatt gggctcttgt gtataaagtt ctccgtcata cgtatagcac aaagttcctt
     6601 tatcgctgat tgacaagaaa cgcaccggat gcgtgcggaa agtggtgatg gctttcactt
     6661 cctgcggagt gttcagggca aagttatata cattaaatga accgccattg cgctcactta
     6721 gaaaataaac cgaattacca tccggtgcat ataccggatt acggtcttct ccttcccgat
     6781 tggtcagatt ggtatgtttt ccggtcgaag catcgtatag ccaaacgtct cttgttatag
     6841 atgaggtatg gtgttttctc cattcatctt caaaaccttt acggtcctga taaaggaagt
     6901 tttttcccga tttatcaaag catacccatt cggcaggagt agccaacact tgttcggtac
     6961 gtcctccggt aaccggaact ttatataatt ccgtcatggc tccggtagga aaaagggcac
     7021 tttgcgcagg gtcctgaatg gaggcggaga aaagtacaaa tttaccatcc ggagtgaaag
     7081 ccgaaggaat ctccgaggca gaatgataag tcaaccgacg tgcagttcct ccatcggcag
     7141 gcatgataaa gagatcgaag ttcccattcc ggtcgctggc aaacgcgatt tgtttaccat
     7201 ctggcgacca gacgggatta gcctcataag aagcttgtgt tgttaattgg gtagcggttc
     7261 ccccttgaac ggggactttg taaatgtcgc ctttataaca aaagacgatt tcctttccgt
     7321 ccggtgagat acgtgcatca cgcatccaca aaggagtaat agcatagctg gataatgcag
     7381 tcagtaccag cgctaaagag atgattattt tcttcatatt attgtatgtt tatatattta
     7441 ttctatattc cttgtttcat gagaagaccg tatttctagt tagtttaagt cacttccgat
     7501 attttagcga ttttttccat gtgactgctg tctgttccac aacacccacc aaatatttta
     7561 agatgacaat cagatttcaa ctttaaaata gcttcactca gatcggctgc cgaagaagta
     7621 tgtaaatgat ttgctccatc caattcttta tatgacaatt gggaagtatt tgcttgtata
     7681 ccccaaaagc gagattttac cgtttgtgtt tgattgaact tatgagaaag tgcttcgtaa
     7741 acaatatcag gatgaacaca atttgtcata tagcacacag gtttgttaga cacatgatta
     7801 tcaatgcaat gtatggcatc atcaatggta tgcccatcta tcagttttcc gtctctttga
     7861 atcgtaaagc tgataatata aggaatatcc gtatcagaca tagcgactgc catcccgata
     7921 gcttccgtca atacaggcat aatacctgca tataaaaaat caactttggc agatttaaac
     7981 aaaccggcct gccaactatg gaagtctatt gcctcttcca gatttagagc ctcttcgcca
     8041 gtgtatgcat ctcccttaca tcccatcaaa ccaccgatat acatatctac atttgctgct
     8101 tcttttatgg aacgaagaaa atccacatta tctgcaataa tggattcatt gtatccagcc
     8161 atataaatcc gttctttatt ggcccttctt gttggagttg ttgcaagaaa tggtagttga
     8221 tacctatatg caatatcaat atattcattc catagcgttt ctaatgccag tctacctttc
     8281 tgctgataga ctaagtcagc cattgcaaca gtaccactga tatccaaatc aaactccctt
     8341 tttagtcgct cgcctaaagc accttccatt aatataaagg gataagaatc tatgcagtct
     8401 ttaaaattca tccagtttgt ttttatatat tcttgtttag tcgtctcaga taattataac
     8461 agagaatccg tctgaatcaa tttccctgta tggttataaa atattctgtc tccaaaatcc
     8521 ttatagaaga aagcatattt atctactccc gtacaatggc agacacctat cttttgaggt
     8581 aaatattcgt gcaaataatc agcaataacc tgatatttgg attcttctgc attatgaaca
     8641 tgaaatccac ctaaaagcaa attacagggg agttccggaa atgccgttct tacagtccgc
     8701 aatatatttg taataccccg gtgggaacag gcacttaaaa tggaaagtcc ttcaggctca
     8761 accagtacca tagctaactc gtccggaaag gtatcgggga ctctagaacc atcttccttt
     8821 tgaatccaaa atcgttcaaa atgtgtatcc ttccggtcta taatatccac agagggaaaa
     8881 agaaatactc cgggaaccag ttcagtcaac tcatcaataa aacgaaaacg agaaagatca
     8941 agcgagcgtg tatatttcat tccattctca cgttcatcct tgaatttagg aaaaaacact
     9001 tcgcgtttgc aaacaaccgt tgcttcggca tttagttcaa gaaaatggcg tagtccaccc
     9061 gtatggtcac tgtgaccatg agataatact aaataatcta ctttttgcaa gtcaatattc
     9121 aataaccggg cgttacggat aaataaatca gaagctcccg tatcaaaaag taatctgttt
     9181 tccggtgtct caatatagag ggaaagacca tgttctgcct gcaatttacg tccatagaca
     9241 caattttcga caagagtcgt tattttatag ttcatgtggt ttggttctta atcaaatact
     9301 acgaaataaa aagttctgct acaaaattat aataattcta cggcagaaca agtaatcaat
     9361 caatttaaat cgactgtaag ggtaaaagat tttgtttcag gcttctattg ccgaattatt
     9421 cattttgtag tttgaataca aataattact tttacatcca tatcaaaccc tttaaataaa
     9481 gaatcaaaat ggagaaagaa gcaaaaggta aagtaaatac agttcagata cagtactatc
     9541 aatctccatg cgggaaattg atactcggtt ctttcgagaa caagctctgt atgtgtgact
     9601 gggtggtgag tgaagaacgc agagcaacaa tcgataaacg aatacaaaaa gcgctaaatg
     9661 ctcagtacgc aatagaaaac tctgaagtga taacgcaaac gatcagtcag ctagatgagt
     9721 atttttcccg tcaaaggact acgtttgata ttcctctgct tcttgtcggg acagagtttc
     9781 aaaagagtgt atggaatgaa ttattaaaca ttccctacgg aacaacgata tcttatgctc
     9841 aattatcaca gagactggat aatcctaaag ctatccgcgc ggtagcctct tcgaatggag
     9901 caaattctat ttcaatactt attccttgtc acagggtgat cggcagtgat cataaactga
     9961 ccggatatgc cggtggtctt gtagctaaaa agactttatt ggaactggaa tcgaacgaaa
    10021 gaagattatt gtaacagaat cattaaacta aacttctctc attaaatcca gacaaaaata
    10081 tggtgtcact atcccattac tatagtgtca ctatcatact gctttagtgt cactatccta
    10141 caggtatagc gtcactatat actcagcata gtgacaccat cctgaaaggt tgttatataa
    10201 gacgggaaat gtttacctaa agcgaacgtt tacaccattt ttcccatctc ataggcttcc
    10261 tgcatgtagg gagtatcttt tatttctcct accttccagg cacctattcc ataaatcact
    10321 cctttttcct gcggattttc cagacaatca aggaagccac ggaaaccatc aatcgtacgt
    10381 tccatcatcc ccttatcatt ctccgccgct gcaataatga aataaaattc cttattcgtt
    10441 atttccgtat aacgcgcaca acaacggtca atcataatct tcatctgtcc acacatcgta
    10501 tagaaataaa caggtgttgc cattacgatg acatcagcag caatcatttt ctctacaatt
    10561 cctgcggcat catctttctg ggggcagggt ttgccataca tgctgcaaac actacatccc
    10621 gtacaaggat gaattgcttt ctctttcaga aaaatctttt ctacttcatt gcctgtttcg
    10681 aggacacctt tcataaattc gtcacaaagc atatcagaat taccgccctt tcgggggctg
    10741 gacgaaataa tcagaacttt tttagccata actttattac ttttattttt tgaatttcat
    10801 taatcagctt tttcactctg caaaaataga caatttatca tatagcaaat gtagataaat
    10861 tacagagatg tgtaccctaa ttactgattc aaacattttc tgccattttt actttttatc
    10921 aatatccttt tcatctcatc cataatcggt ctttcggcgg cacaaacata aaaaaagatt
    10981 ttctctgccc atatataatt catatctttg cccatgatac gaacaacata atgcaatgaa
    11041 aaaaatacaa ctgaccaacg cacataaaga aaaattattt caaatccctt tatttcggga
    11101 tttacctctg aacattaagg aatctctgtt ggacaaactg gatttcgtta tctatgcagc
    11161 ggataaaaaa gaaatagttg ttacgcaagg tacaccttgc aacaaactat atgtgttatt
    11221 ggaaggaaaa ctacgcacgg atatcattga cggattgggg aacgaagtga tgattgagta
    11281 tatcatcgca ccacgtacct ttgccacccc tcaccttttc aattcaaaca atacgttgcc
    11341 agctactttt actgctttgg aagacagcgt ggtactcatg gcaaccaaag attccacttt
    11401 taaagtcatc agtcaggacc cgcaggtgtt gcacaatttt ctttgcatcg ccggaaattg
    11461 caatatatgt accgtatcac gtttgaaacc tctgtcgcgc aagactgtac gcgaaaggtt
    11521 tattgtttac ttattcgaac ataagaaaaa agattctctg actgtagaga tcatgcatac
    11581 ccagtcacag cttgccgagt atctgaatgt atcacgtcct gctttatcca aagaaatcaa
    11641 taagataatc aaggaaggac tgatcacaat ggaaggaaaa aagatcgaga ttctgaataa
    11701 aatggcgctg gagaaatact tataataaaa agaaagtggc acagcctaaa tttaatgctg
    11761 tgccactttt tatattctat caacggttta atctgaatcc tagctaggtt tcaattacca
    11821 ttttgtaaaa aacactttcg ggttgatatt gacagatacc catccccagt cttgccaact
    11881 cttatgattt ccacctttca cagcatccat cgtcttcgtt ccaagcataa aagaataacc
    11941 ggcagagagt ttcacatctt tcattacaga ccaattgatc tgatagtcaa cttccgaacc
    12001 gagtgacttc ttcaaatctt ctttaaaatc tacttcagta gcagtagcaa aataatgata
    12061 attgagttcc atatctacct tggcagatgc acgaaaacga gccccaagac gaccatctat
    12121 taatccggga gcaaatcctt tgttgaatgc agaagcgtag aaataatcca tgctgccata
    12181 gaatttatga tgcgtcccat aaagagggtc aaaagcctta aatttactac taccttcttc
    12241 atttccgctc aaataatcaa aacttacaac cattccccat gtcttattga acgcataagc
    12301 tgccgtagca cttgccataa aagcggaaac gctctcggca tccttgttct tacctgtttg
    12361 gtagtagaaa gcgccatcca ggttccatcc gctattttta tatgtaagat aagttcccat
    12421 cgtttgcaag tagcgggtat gagaatcttg agtgagctga ttccctgtct ctaatcctaa
    12481 attcataaac agtaaagaag ccccgaacgg aatcttatct gctttatagt gataccacac
    12541 agtctgcata ttcttgtaag gctgaccaat agaagaattg taataagtac cacctgccgt
    12601 tttttcatca ttctggttga aagccagaat agcatgtatt tcattattct tattggcata
    12661 tcccagtttc aacgcatcat gataacggcc tgccacattc cagtccagtc cgcccaaaat
    12721 acgttcatca tcataaatta acgtctgacg acctaactgt gcaaagaagc cttttccaaa
    12781 atccagcttt gcccatgcct cattcaagat aaagcgacca ttcttgtcaa tctgcggatc
    12841 ttgtccccat actccgacat gctgtgccga catcttgatt tcaaggtccg aacgcttgta
    12901 gtccagtgac aaacgggcac ggttattaat aaatgatgca gccttctgcc cttcattgcg
    12961 agggactaaa gcaccgtttc gatactccgc acgaggtctg atttgcatag acatcgaaaa
    13021 ttcattttcc ttctccgtag tttgtgtgta tgccatgctt ggcaatagca taagaacgaa
    13081 tgaccaataa aatgttttca ttgatatttc aatttaagtt ataagtatgt acactaactc
    13141 cttgtgccga tggaagataa ttgattccat accaacacat ttgtaataag acaaatgata
    13201 ctaacagaat gactaatgcc ggacgactct tcaacggtct gcccagtctg aaatggatat
    13261 ataccagata ggagaaccaa gtagctgccg cccatgtctc tttcgggtcc caagcccagt
    13321 agtgccccca tgcttccttc gcccagatag ctcccgtcag cattcccaat gtcataaatg
    13381 ccaagcctac ataagtcagg ttatcgcata agtccatctc tttccgttca atatccttct
    13441 ttttgaacca aagcagataa acagccatga ccaccgcagc tcccaacatc gcataagcaa
    13501 acatatagac tatgacatga ggggcaaacc acggactttg caaagcaggc atcagcgttt
    13561 tattgtgaat ctccggttta aagatattga tacagataaa taccagtgag agaatgcaac
    13621 tgaaactaag aatccattta tatttccaac gcacgtacgt tatcaaacca gccaatggaa
    13681 ggaagaaaga ataccacaga cgtgtctctc ccatcgtccg catcggagga cgttccagag
    13741 aaatccacat accgaggata aaactgaaaa agatgaccag ccccaacaag gtaaatccat
    13801 aggtccatac cggcttcttt cctttccagg cagcaaacgc gcccaagctc cagcaaatca
    13861 atgcggctat cgcaaaccat ataaaatgtt cccaactcat tccttgtcct cctctttcct
    13921 cttttgtgca ttgacaaaca gacaaattgc tccgagcatc atcatgatga tccctgcata
    13981 tactacaggc aaccacgggt cgcgaaccag
//
