LOCUS       c00055_gnlPro..        16301 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JGKMCPAE_55.
ACCESSION   c00055_gnlPro..
VERSION     c00055_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 21:54:47
            Original ID  :: gnl|Prokka|JGKMCPAE_55
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16301
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16301
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2749:6301](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2750..6301
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16301
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16301
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(177..1304)
                     /locus_tag="ctg55_1"
                     /transl_table=11
                     /translation="MAPASARQMASELALLPMWYAEEGSVVLAPSAYNLDYVKKIQELL
                     GLSVDLMTEPELASERNLDIRPWGWDIAIRKRLLDLGVEESELPSIEQLDKLRFCSHRS
                     CAVGLLPQLQLGACFCGESFYLTFPEEWKSFVESHDTCLLKAPLSGSGKGLNWCKGVYT
                     PSISGWCSRIGKQQGGVIGEPLYNKVEDFAMEFRSSSNGRFGFAGYSQFRTGGSGAYEG
                     NLLISDAAIERNLLEYIPVEEIYKLRDRLEQELSLRFGTIYNGYLGVDMMICRFPESPV
                     YRIHPCVEINLRMNMGVVARHIYDHYIYPTSTGAFQISYYPTEGTAWRAHKEMEEAYPL
                     EIEQGRIKSGYLSLVPAHKKSSYRAWVFISKSVFL"
     CDS             1539..2717
                     /locus_tag="ctg55_2"
                     /transl_table=11
                     /translation="MESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGIKGTRGVGKT
                     TFLLQYAKEKFGNDRSCLFINMNNFYFSGHSIVDFANEFQKRGGKVLLIDQVFKHPEWS
                     KELRMCYDRFPNLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREYLNLQTGMKFR
                     AYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENLLKTMNMMVE
                     VDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDIQTSRATVMNYIKYLADAR
                     LINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFVNSLWKDHKVHKGD
                     KNVSFMVDEVMPFKICQEGAKIKNNPNVTYALHKAEIGRGNQIPLWMFGFLY"
     CDS             2750..6301
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg55_3"
                     /sec_met_domain="PFOR_II (E-value: 1.4e-18, bitscore: 57.9,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 1.6e-82, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 1.6e-31, bitscore: 100.4,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.3e-12, bitscore:
                     37.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 5.5e-12, bitscore: 37.3,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 8.9e-09, bitscore: 26.0,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 4.4e-05, bitscore: 14.8,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 2.7e-25, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMNPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKTIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQILSVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIALEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLAVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNPENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKVFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKTKQHLVDIKSNVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTTNENGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARIVKLFNEILAADNASPEAKEVLKAWIENMYDADKTKE
                     LAPQVKAVIEEGLSHGCPICKELKGLTQYLVKRSQWIIGGDGASYDIGYGGLDHVIASG
                     KDVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQI
                     AMGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLW
                     RYNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPTEAEELFKAAEENAK
                     WRYNSYKRLARENWGAE"
     CDS             complement(6454..7320)
                     /locus_tag="ctg55_4"
                     /transl_table=11
                     /translation="MRIYKIVGIVLSAMLLLASCTNSDLEKKKVKIAYANWLEGIAMSH
                     LAKVVLEEHGYEVELQNADLAPIFVSMSGKKSDVFLDAWLPITMKDYMDQYGDSIEFFG
                     EVYGEARVGLVVPQYVTIHSINELEANKDRFSSEIVGIDAGAGIMKTTDKAIAAYGLDG
                     YTLMTSSSSTMLASLKKAMDKGEWIVITGWTPHWMFDQFDLKFLDDPKKVYGDLEEIHA
                     IAWKGFSEKDPFAAEFFGNIKLTTEELSSFMTAMKDARMDEEEIARKWRDEHRLLVDSW
                     IPKSENK"
     CDS             complement(7341..8165)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 92.9; E-value: 6.9e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg55_5"
                     /sec_met_domain="BPD_transp_1 (E-value: 2.8e-29, bitscore:
                     92.9, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIEMAINWMMIHFSTFFDAVNAGIGSFIIGFQHILFGIP
                     FYITILVLAALAWMKAGRGTAIFTALGLLLIYGMGFWEATMQTLALVFSSTCLALIVGV
                     PLGVWTANSSRAEKILRPVLDLMQTMPAFVYLIPAVLFFGLGAVPGVFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATRWQLLYKVQLPLALPTILTGVNQTIMMSLSMVVIA
                     AMIAAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIILDRITQGMAGRKNKN"
     CDS             complement(8162..9388)
                     /locus_tag="ctg55_6"
                     /transl_table=11
                     /translation="MSKIEIKDLYLIFGNEKQKALKMLKKDKSKEEILKDTGCTVGVKD
                     ANLSINEGEFFVIMGLSGSGKSTLLRCINRLIRPTTGQVLVNGVDISKISEKELLQVRR
                     KELAMVFQNFGLLPHRSVLSNIAFGLELQGVKKEEREKKAMESMKLVGLKGYENQMVGE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLALQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEVVQVGTSEEILTEPANDYVARFVENVDRSKIITASSLMID
                     KPLVARLKKEGPEVLIRKMRAKNITVLPVIDADDKLVGEVRLNDLLKLRSKQEKSIETI
                     VRTEVHSVLEDTVLEDILPLMTKSNSPVWVIDETREFLGTIPLSSLIIEVTGKDKEEIN
                     EIIQNAIDL"
     CDS             complement(9688..10026)
                     /locus_tag="ctg55_7"
                     /transl_table=11
                     /translation="MKDYKVDKASLSASFCQEVYQVVREIPVGKVSTYGGIAALLGMSQ
                     CSRMVGRALKQIPDDLSAPCHRVVNASGRLVPGWTEQKQLLLEEGISFKQNGCVDLKKH
                     LWNYSVPE"
     CDS             10110..11405
                     /locus_tag="ctg55_8"
                     /transl_table=11
                     /translation="MQLYLLYLQIIPTFVPIKSNPIINKTSTAVMKKKTILFASCLLGA
                     LAFSSCEKNLYDESKQPEKEKKMTDLEVPADFDWKGSQNAKVKIASQSTATISVFLEEN
                     CNEEALMLRMDVDANTSKLELPIEIPAYIKNVYVKYGNGSEIQTVPVESNGTISIVVPA
                     NATALSRVTTRANKEVETNNIFNYPGYGNGTIMFEDMYPALGDYDFNDFVAWYNFQIDG
                     FYWSHNQCYAEYLMIGFQIRAIGGIYDYNPYIRLAEVQYNELDLEETQMYLERNNPEEA
                     ENIKILKGPKGELIISLKKPAIPNGYKYYNTEVNEKTKPKKMMAIYLVFNSPVNVKSLQ
                     DSKMDFYIAKTNKGQEIHLKGYSPVYYNSNESYVNEDNFIWGLKVPASLHHAREEVNFL
                     EAYPDFEQWVTSGGQENQRWWNKPKTNKLIMN"
     CDS             complement(11545..14385)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 63; E-value: 1e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg55_9"
                     /sec_met_domain="Peripla_BP_1 (E-value: 4e-20, bitscore:
                     63.0, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEAMKYTKWITVLFCLLGLAACRQDAPRFRIGVAQCSDDSWRHK
                     MNDEILREAMFYDGVSVEIRSAADDNRKQAEDVHYFIDKGVDLLIISANEAAPMTPIVE
                     EAYQKGIPVILVDRKILSDKYTAYIGADNYEIGRAVGNYIASSLKGKGNVVELTGLGGS
                     TPAMERHQGFMAAISNYPDIKLIDKADAAWEREPAEVEMDSMLRRHPKIDAVYAHNDRI
                     APGAYQAAKKAGREKVMIFVGIDALPGKGNGLELVLDNVLDATFIYPTNGDKVMQLAMN
                     ILEKKSYPRETVMNTAVVDRTNAHVMQLQTTHISELDQKIETLNGRIGGYLSRVATQQV
                     VMYGGLVILLLVAGLLLVVYKSLRSKNRLNKELSEQKKQVEQQRDKLEEQRDQLIQLSH
                     QLEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADSSLSEDQRRMLLLVQRNVNILL
                     RLVNQILDFRKYENGKMEYTPISLDILSSFEGWNESFMAVARKKHIHFSFDYMPDTDYR
                     TLADVEKLERIYFNLLSNAFKFTPENGKVTVRLSSLTKDDHCWIRFTVANTGSMISAEH
                     IRNIFDRFYKIDMHHAGSGIGLALVKAFVELHKGTITVESDEKQGTIFTVDLPVQTCET
                     VVSENSPAFSVSATSVTSTDATTSAVAGVPATPATSGYSGSSSLNDALTYEEEELEKSY
                     DSSKPCVLIIDDNADIRLYVHGLLHTDYTVIEAADGSEGIRKAMKYVPDLIISDVMMPG
                     MDGIECCRRLKSELQTCHIPVILLTACSLDEQRIQGYDGGADSYISKPFSSQLLLARVR
                     NLIDSHRRLKQFFGDGQTLAKEDVCDMDKDFVEKFKALIEAKMGDSNLNVEDLGKDMGL
                     SRVQLYRKIKSLTNYSPNELLRIARLKKAASLLASSDMTVAEIGYEVGFSSPSYFTKCY
                     REQFGESPTDLLKRKG"
ORIGIN
        1 gtaaactaac ttaggtataa caagcgaagt tgtcaactaa atccagtaca gtacacacat
       61 ggcatgtgat tacttgtttc atgcaatgaa actttttgtt tctcggtgtg gaaccaatgg
      121 tttcactaca tgaaactatc agtttcacac cgagaaacca taacttcgat ataatatcac
      181 aaaaacacgc tttttgagat aaacacccac gcccgataac tactcttttt atgagccggc
      241 accaatgaca aatagcctga ttttattctt ccttgttcta tttccaaagg ataagcctcc
      301 tccatttctt tgtgtgctct ccaggctgtt ccttccgtag ggtaatagct tatttgaaaa
      361 gctcctgttg aagtaggata gatataatgg tcataaatat gacgcgctac tactcccata
      421 ttcatcctca agttgatttc cacgcaagga tgaatccgat aaacaggaga ttctggaaag
      481 cgacagatca tcatatccac tcccaaataa ccattataaa tggttccgaa acggagggat
      541 aattcttgtt caaggcggtc gcgcaattta taaatttctt cgacagggat atattccaaa
      601 agattccgtt cgatggctgc atctgaaatc agcagattac cttcgtacgc cccacttcca
      661 cccgtacgga attgagagta tccggcaaag ccaaatcgac cattactcga agaacgaaat
      721 tccatagcaa aatcttccac cttattatat agaggttcgc caataacacc tccttgctgt
      781 ttgccaatgc gtgagcacca accggaaata gaaggagtat atacaccttt gcaccagttc
      841 agccctttcc cgctaccgga taaaggagct ttcagtaaac aagtatcatg tgattctaca
      901 aatgacttcc attcttcggg aaacgtcagg taaaaagact ctccacaaaa acaggctccc
      961 agttgtagct gtggtaataa tcccacagcg caggaacgat gggaacagaa acgcagttta
     1021 tccaattgct caatagaagg aagctcgctt tcttccactc ccaaatccaa cagtcgtttt
     1081 cttattgcta tatcccagcc ccaaggacga atatccaaat tccgctccga agcaagttca
     1141 ggttctgtca tcaaatcaac cgaaagtcct aataattcct gtatcttctt cacatagtcg
     1201 agattataag cggaaggagc caatacaaca cttccctctt ctgcatacca catcggcaac
     1261 aaagccaatt cggatgccat ctgccgggcg gaagccggtg ccatatagtt tgtttcaccg
     1321 ctggctaacg ccaaatcatg ttccggattg aatatataaa gagccttttt tgtcatttta
     1381 aacgaattca aaactttatt ctgcaaatat atacaggaaa tagtcaggaa tggctacaat
     1441 aaacagaaag ttctaattaa actcacaatt ttgccatctc tactttgcaa atcctaaaaa
     1501 aagcagtata tttgccaccc gaaaaacaaa gaactgaaat ggaatcattc tatcgcacac
     1561 acgcctacct cgttgagcac accaatgccc ccgttcgccg cgatcttatg gacgagatcg
     1621 actggagcga ccgcctgatt ggtatcaaag ggacacgtgg cgtaggaaaa accactttcc
     1681 ttctccaata cgccaaagaa aaatttggga acgaccgctc ctgcctgttc atcaacatga
     1741 acaacttcta cttctctggc cacagcattg tagactttgc taacgaattt cagaaacgtg
     1801 gcggaaaagt attgttgatc gaccaggtgt tcaaacatcc ggaatggagc aaagagttac
     1861 gcatgtgtta cgaccgtttt cctaacctga aaattgtctt caccggctcg tccgtgatgc
     1921 gactgaaaga agaaaatctt gaattacgtg atatcgccaa gagctataac ctgcgcggat
     1981 tttcttttcg cgaatacctg aacttacaga caggcatgaa attcagggca tacagcctcg
     2041 aagaaattct tagcactcac gaacagattg ccaaaggagt actctctaaa gttcgtccgc
     2101 tggattactt ccaggattac ctgcatcatg ggttctatcc gttcttcctc gagaagcgta
     2161 acttctcgga gaatttgctg aaaacgatga acatgatggt ggaagtagat atacttctca
     2221 tcaaacaaat tgaactgaaa tatctttcaa agataaaaaa attactatat ttgctcgctg
     2281 tcgacgggcc gaaagctcca aatgtgagcc aactggcaag cgacatacag acatctcgcg
     2341 ccacggtgat gaactatatc aagtatctgg cagatgcgcg actcattaat ctggtttatc
     2401 cgaaagggga agaattccct aaaaaacctt cgaagataat gatgcacaac tccaacctga
     2461 tgtattccat ctacccggtg aaagtggagg agcaggatgt gctcgacact ttctttgtga
     2521 attctttatg gaaagaccat aaggtacata aaggagataa aaacgtctct tttatggtgg
     2581 acgaagtaat gccgttcaaa atttgccagg aaggagcaaa gatcaagaac aatccgaatg
     2641 tgacgtacgc gttgcataag gctgaaatag gtcggggcaa ccagatacct ctctggatgt
     2701 tcggcttttt atattaaaag atttatttac ttaaatattt aatttagtta tgactaaaca
     2761 gaagaaattc atcacttgtg atggtaacca ggctgcagcg catatctcgt atatgttctc
     2821 tgaagtagct gctatctacc ccatcactcc ttcttcgact atggctgagt acgtagacga
     2881 atgggctgcc gcaggacgta agaacatctt cggcgaaaca gtattggtac aggaaatgca
     2941 atctgaaggt ggtgctgccg gtgcagttca cggttctctt caggctggtg cgttgactac
     3001 tacttacact gcttctcagg gtcttctcct gatgatccct aacatgtaca aaattgccgg
     3061 tgagttcttg ccttgcgtat tccatgtatc tgctcgtaca ttggcttctc acgcattgtg
     3121 tatcttcggt gaccaccaag acgtaatgtc agctcgtcag actggctttg cgatgttggc
     3181 tgaaggctct gtacaggaag ttatggattt ggctggtgtt gctcacttgg ctactatcaa
     3241 atctcgtgtt ccgttcatga acttcttcga tggtttccgt acatctcacg aaatccagaa
     3301 gattgaaatg ttggaaaatg atgatcttgc tccgctgatt gatcaggaag ctttggctga
     3361 attccgtgcc cgcgcactga atccgatgaa tccggttgct cgtggtatgg ctgaaaatcc
     3421 tgaccatttc ttccaacatc gtgaatcatg caacaactac tatgaagcag ttcctgctat
     3481 cgtagaagaa tacatgaatg aaatttctaa gattacaggt cgtaaatacg gtttgttcga
     3541 ttattatggt gcagaagatg cagaacgcgt aattatcgct atgggttctg taacagaagc
     3601 tgcccgcgaa gctatcgacc acttggtagc aaatggcgaa aaagtgggta tggttgccgt
     3661 acacctgtat cgtccgttct ctgctaaaca cttcctggct gctgtaccta agactgccaa
     3721 gactatcgca gttcttgacc gtactaaaga accgggcgct aacggcgaac ctctttacct
     3781 tgacgttaaa gactgcttct acggcgcaga aaatgctccg gttatcgttg gcggtcgcta
     3841 cggtttgggt tcaaaagata ctactcctgc tcaaattctt tcagtattcg agaacttggc
     3901 catgccaatg ccgaagaatc acttcactat cggtatcgta gacgacgtta ctttcacttc
     3961 tcttcctcaa aaagaagaaa tcgctttagg cggtgaagga atgttcgaag ctaaattcta
     4021 cggtttgggt gctgacggta cagtaggtgc taacaagaac tctgtaaaga ttatcggtga
     4081 caacactgac aaacactgcc aggcttactt ctcttatgac tctaagaagt caggtggttt
     4141 cacttgttct cacttgcgtt tcggtgatac tccgatccgt tccacttatt tggtaaatac
     4201 tccgaacttc gttgcttgtc acgttcaggc ttacctgcac atgtacgatg taactcgtgg
     4261 tttgcgtaag aacggttctt tcttgctgaa cactatctgg gaaggtgaag aactggctaa
     4321 gaacctgcct aacaaggtta agaaatattt tgcacagaac aacatttccg tatactatat
     4381 caacgcaaca cagattgcat tggaaattgg tttgggtaat cgtaccaaca ctatccttca
     4441 atctgcattc ttccgtatca caggtgttat tcctgtagac caggctgttg aacagatgaa
     4501 gaaattcatc gttaagtctt acggtaagaa gggtgaagac gttgttaaca agaactatgc
     4561 tgccgttgac cgtggtggtg aatacaagac tttagctgtt gatcctgctt gggctaacct
     4621 gccggatgat gcaaaagctg aaaacaacga tcctgcattc atcaacgaag tagttcgtcc
     4681 gatcaatgca caagatggtg acttgctgcc tgtatctgca ttcaagggta tcgaagacgg
     4741 tacttggtat caaggtactt ctaaatacga aaaacgtggt gtagccgcat tcgttcctga
     4801 atggaatcca gaaaactgta tccagtgtaa caagtgtgca tacgtttgtc ctcacgcttc
     4861 tatccgtccg ttcgtactcg atgctgaaga gcagaagggt gctaagttcg aacaattgaa
     4921 agcagtaggt aaagtattcg acggtatgac attccgtatc caggttgacg ttctcgactg
     4981 tctgggttgc ggtaactgtg ctgacatctg tccgggtaat ccgaagaagg gtggcaaagc
     5041 attgacaatg aaacacctcg aaagccaatt ggctgaagct gacaactgga cttactgtgc
     5101 tgaaaacgtg aagactaaac aacatcttgt tgatatcaag tctaacgtga agaactcaca
     5161 gttcgctact ccgttgtttg agttctctgg tgcttgctct ggttgtggtg aaactccgta
     5221 tgtgaaattg atttctcaat tgttcggtga ccgtgaaatg gttgctaacg ctaccggatg
     5281 ttcttctatc tactctggtt cagttccttc tactccgtat actacgaacg aaaacggtca
     5341 cggtcctgct tgggctaact cactgttcga agacttctgt gaattcggtt tgggtatgga
     5401 attggctaac gaaaagatgc gtgctcgtat cgtgaagtta ttcaacgaaa tccttgctgc
     5461 cgacaacgct tcacctgaag caaaagaagt gctgaaagca tggattgaaa acatgtacga
     5521 tgctgacaag actaaagaat tggctcccca agtgaaagca gtgattgaag aaggtctttc
     5581 tcacggatgt cctatttgca aagaactgaa aggactgact caatatcttg taaaacgcag
     5641 ccaatggatc attggtggtg acggtgcttc ttacgatatc ggttatggtg gtcttgacca
     5701 tgtaatcgct tccggtaagg acgttaacat cctcgttctg gatactgaag tttactctaa
     5761 cacaggtggt cagtcttcta aggctactcc ggtaggtgct atcgctaagt tcgctgctgc
     5821 tggtaagcgc gtacgtaaga aagacctcgg tctgatggct actacttacg gttatgtata
     5881 tgttgcacag atcgctatgg gtgctgacca agctcaaact ctgaaagcta tccgtgaagc
     5941 tgaagcatat ccgggaccat ctttgattat cgcttacgct ccatgtatca accacggtct
     6001 gaaagcaggt atgggtaaga gccaggaaga agaagaaaaa gctgttaagt gcggttactg
     6061 gcacttgtgg cgttacaacc cagctttgga agaagaaggc aagaacccat tccaattgga
     6121 tagcaaagaa ccgaactggg aagatttcca aggtttcttg aagggtgaag ttcgttacgc
     6181 ttctgtaatg aaacaatatc ctactgaagc tgaagaactg tttaaagctg ctgaagaaaa
     6241 cgctaaatgg cgttacaaca gctacaaacg tttggctaga gaaaactggg gtgctgaata
     6301 atagtaatac cctataaata taaagcggta atcttatcaa agattaccgc ttttttattg
     6361 tatgaactct gtccaacata aacagtactc cctttttccc actagagttc atgtctattt
     6421 tatatttaaa attaagaata acaatgctcc aatctattta ttctctgact tcggaatcca
     6481 actatccacc aacagccgat gctcatccct ccatttacgg gctatttctt cttcatccat
     6541 cctggcatcc ttcatagctg tcataaaaga gctaagttct tctgtcgtta gtttgatgtt
     6601 gccaaagaat tcggcagcaa acggatcttt ctcactgaat cctttccatg caatagcatg
     6661 tatttcttcc aagtctccat atactttctt cggatcatcc aagaatttca agtcaaactg
     6721 gtcgaacatc caatgcggtg tccaccccgt aatgacaatc cattctcctt tgtccatcgc
     6781 ttttttcaaa gaagccagca tggtggaact acttgaagtc atgagggtat acccatcaag
     6841 tccgtaagca gcaatggcct tatcggtcgt cttcattatc cctgctcccg catcaattcc
     6901 tactatttca gaggaaaaac ggtctttatt agcttccagc tcattaatag agtggatcgt
     6961 aacatattga ggaacaacca gtccgacgcg agcttctccg tatacctccc caaaaaattc
     7021 gatgctgtct ccatactgat ccatataatc tttcatcgtt attggtaacc atgcatccag
     7081 aaacacatct gatttctttc ctgacataga tacaaaaata ggggcaagat cagcattttg
     7141 caattcaacc tcatatccat gctcttccaa taccacctta gccaaatgac tcatggcaat
     7201 accttccagc caattggcat aggctatttt tactttcttt ttctctaagt ctgaattagt
     7261 acaggaagct agcaaaagca tagctgacaa tactattcct actattttat atattctcat
     7321 acgtatttta tcctttccgt ttagttctta ttttttcgtc ctgccattcc ttgcgtgata
     7381 cggtctaaga tgatagctaa aataacaact gctataccac cttcaaaccc aagtccgatt
     7441 ttcatttggg taataccttt caatacaatt tctcccagac caccggcagc aatcatggca
     7501 gcaattacaa ccatagaaag cgacatcatt attgtctggt tgacaccagt cagaatggtg
     7561 ggcaacgcca aaggaagctg cactttatac aataactgcc aacgggtagc tccgaacgaa
     7621 cgggaagctt ccactacatt tttaggaact tgccggattc ccaatccggt aaggcggacc
     7681 acaggaggca tagcaaagat aatggtggca aacactcctg gcactgctcc caatccgaaa
     7741 aacaaaacag caggaatcag ataaacaaaa gcaggcatcg tctgcatcaa gtcgagaaca
     7801 ggacggagta ttttctctgc acgcgaactg tttgccgtcc atactcctaa aggtacacca
     7861 acaatcaggg ccagacaggt agatgaaaaa acgagagcta gagtttgcat ggtagcctcc
     7921 cagaatccca ttccatagat cagtaataat cccaatgcgg tgaaaattgc cgtaccgcgt
     7981 cctgctttca tccatgcgag tgcagcaagt accaaaatgg ttatataaaa aggtattccg
     8041 aaaagtatgt gttggaatcc tataataaaa ctaccgatgc ccgcattcac ggcatcaaag
     8101 aaagtggaaa aatgtatcat catccaattg atggccatct ctatatattg tcctatattt
     8161 atcataaatc tattgcgttt tgaattattt cgtttatttc ttctttatct ttcccggtca
     8221 cttcgatgat taaggatgaa agcgggattg ttcctaaaaa ctcgcgcgtc tcatcaatca
     8281 cccataccgg cgaattgctc tttgtcatta gaggaagtat atcctccaac accgtatcct
     8341 ccaacacaga atgtacttct gtacgcacaa tcgtttcaat ggatttttcc tgtttgctac
     8401 gtaacttaag caagtcgttc agacgtactt ctccgaccag tttatcatcg gcgtctatga
     8461 caggtaatac ggtgatattc ttcgcacgca tcttacgaat caatacttcg ggaccttctt
     8521 tcttcagacg ggccaccaac ggtttgtcaa tcattaaaga agaggcggta ataattttgc
     8581 tcctatccac gttttcaaca aaacgggcta cataatcgtt agccggttca gtcaggattt
     8641 cctccgaagt acctacctgc accacttctc cgtctttcat gatggcaata cggtcaccta
     8701 gcttaattgc ttcactcaag tcgtgggtaa taaaaacaat cgtctttttc atctttgatt
     8761 gcaaggccag tagttcatcc tgcatctgta cgcgaatcag aggatcgaga gcagagaaag
     8821 cctcatccat taaaagcact tcaggattat tagccagagc gcgagccagt ccgacacgct
     8881 gttgcattcc accggaaagc tcgcctacca tctgattttc atatcctttc aatccgacaa
     8941 gcttcatgct ttccatcgct ttcttctcac gttcctcttt cttcactccc tgaagttcga
     9001 ggccgaacgc gatattgctc aatacggaac ggtgaggtaa cagaccgaaa ttctggaaaa
     9061 ccatcgccag ctctttccga cgaacctgca ataattcttt ttcggaaatt ttagatatat
     9121 ctactccgtt tacaagcact tgcccggtag taggacgtat cagacgattg atacaacgca
     9181 gtaatgtcga ttttccactt cccgagagtc ccattatcac gaaaaactct ccttcattaa
     9241 ttgaaagatt ggcatctttc actcctaccg tacaaccggt atctttcaga atttcctctt
     9301 tactcttatc ttttttcaac atcttgaggg ctttctgctt ctcgttacca aagataaggt
     9361 acaaatcctt tatttctatt ttactcatat aatatattgg tttagattat aatatttgtt
     9421 ttgttttcaa ctgccgcatt ccttattctc acttacgata aacaagttga atgttcgcat
     9481 ggttcagtca tgtcacatga taacatgacg gtccgacgtt ttttaaatgg ttaaaaaaaa
     9541 acagacagag tagtttaaaa ggaatagaat ttgataagat tatcctctta atgaacagta
     9601 gaaaacagta ttttcataaa taaataacag tctgttcttg catattgttg gcacaaaggt
     9661 aaggaaaata gattaaatat gcaaatttca ttcaggtacg gagtaattcc aaagatgctt
     9721 tttcaagtct acgcatccat tttgtttgaa agagatccct tcttccaaca agagttgttt
     9781 ctgctctgtc caacccggaa caagccgtcc cgacgcattg acaacccgat gacaaggcgc
     9841 agataaatca tccggaatct gtttcaaagc acgccccacc atacgggaac attgagacat
     9901 tcccaataat gcggcaattc ccccataggt agaaacttta cctaccggaa tttctcggac
     9961 aacctgatac acctcttgac aaaaggatgc ggaaaggctc gccttatcta ctttataatc
    10021 tttcatcact caaacattac tttatttcag ttccaaaact agataaaaag aaaagaattt
    10081 gcaaataata aaagcatttc aaataaaata tgcaacttta tttgctttat ttacaaataa
    10141 tcccgacctt tgtacccatt aaaagcaacc ctattattaa caaaacaagc actgctgtta
    10201 tgaaaaagaa aactatcctg ttcgcttctt gtttattggg agcactggct ttcagctcct
    10261 gtgagaagaa cctttatgat gaaagtaaac aacccgagaa agaaaagaag atgactgact
    10321 tggaagtacc tgccgatttc gactggaaag gttctcaaaa tgccaaagtg aaaattgcca
    10381 gtcaatcaac tgctactatt tctgtatttc tagaagaaaa ttgcaatgaa gaggctttga
    10441 tgcttcgaat ggatgtcgat gccaacacat caaaattgga actcccaatt gaaattcctg
    10501 catatataaa aaatgtgtat gtaaaatatg gtaatggctc tgaaatacaa actgttcctg
    10561 ttgaaagtaa tggtactatt tctatagtag tacctgctaa cgctacggca ttatccagag
    10621 ttaccacaag agctaataaa gaagttgaaa cgaacaacat cttcaattat ccgggatatg
    10681 gcaacggaac tattatgttc gaagatatgt atccagcttt aggcgattat gattttaatg
    10741 attttgttgc atggtataat ttccaaattg acggttttta ttggagtcac aatcaatgtt
    10801 atgcagaata cttaatgata ggattccaaa tcagagctat aggaggtata tatgactaca
    10861 atccttatat ccgcttggca gaagtacaat ataatgaact tgatttagaa gaaactcaaa
    10921 tgtatcttga gcgtaacaat cctgaagagg ctgaaaatat caaaatccta aaaggcccaa
    10981 aaggggaatt gattatttca ctaaagaaac cggccattcc taacggatac aagtattata
    11041 atacggaggt aaatgaaaaa acaaagccta aaaaaatgat ggccatttac ttggtgttca
    11101 actcacctgt taacgttaaa agcctacaag acagtaaaat ggacttttat attgcaaaaa
    11161 ctaataaagg acaagaaatc cacttaaaag gttatagccc ggtttattat aacagcaacg
    11221 aaagttatgt aaatgaagac aactttatat ggggattaaa agtacctgca tctttacatc
    11281 atgccagaga agaagtaaac ttcttggaag catatccaga ctttgaacaa tgggtaacat
    11341 cgggaggtca agagaaccaa agatggtgga ataagccaaa aacgaataag ttgattatga
    11401 attaataaat atacagtaaa tcatatactg aattaaataa gaggtaaggt atgtcaatag
    11461 atttccttac ctcttatttt tatcatatga attctagaag tataaacaga taaatgctca
    11521 ccaccaaatt ttgcagattc tatcctatcc tttcctcttc aacaaatctg tcggactctc
    11581 tccaaactgt tctctataac atttagtaaa ataagaagga gaactaaaac caacttcata
    11641 acctatctct gccactgtca tatccgacga agcaagcagg gaagcagctt tcttcaaacg
    11701 agctatacga agcagttcat tcggggaata attagttagg gatttgattt tgcgatagag
    11761 ttgcacacgg cttaatccca tatctttacc caagtcttcc acattcaaat ttgaatctcc
    11821 catctttgcc tcaatcaaag ctttgaattt ttccacaaag tctttatcca tatcacagac
    11881 atcctctttc gccaacgttt gtccgtcacc aaaaaactgt ttcaggcggc ggtgtgaatc
    11941 tatcagatta cgaacgcgtg ccaatagtaa ttgcgaactg aaaggcttgg agatataaga
    12001 atctgcacca ccatcatacc cttgaattcg ttgttcatcc aaagaacaag ctgtcaatag
    12061 gataacagga atatgacagg tttgtaattc gcttttcaag cgacgacaac attcaattcc
    12121 atccattccg ggcatcatta catcggagat aatcaagtcc gggacatatt tcatagcttt
    12181 acgaatacct tccgagccgt ctgcagcttc tataacagta taatcagtat gaagcaatcc
    12241 atgcacatat aagcgaatat cagcgttatc atcaataatc agaacgcaag gtttggaaga
    12301 gtcgtaactt ttttccaatt cctcttcttc gtaagttaaa gcatcattca agctcgaaga
    12361 accggaataa ccggaagttg caggagttgc cggaacccca gcaacggcag aggttgtagc
    12421 atcggtggag gttacagaag tagcagacac agagaatgcc ggagagtttt cagaaacaac
    12481 agtctcgcaa gtctgcacag gcaaatcaac ggtaaagata gttccttgct tttcatcact
    12541 ttccaccgtg atggtacctt tatgcaattc cacaaaagcc tttaccaatg ccagtccaat
    12601 acccgaaccg gcatggtgca tatctatctt atagaaacgg tcgaaaatat tccggatatg
    12661 ctccgcagaa atcattgaac cggtattggc aacggtaaag cgaatccagc aatgatcgtc
    12721 tttagtcagg gaagacaagc gtacagttac ttttccgttt tccggagtaa atttgaaagc
    12781 gttggaaagg aggttgaaat agatgcgttc caacttttct acatctgcca atgtgcggta
    12841 atccgtatcc ggcatataat cgaatgagaa atgaatatgc ttcttccggg ctactgccat
    12901 gaaagattcg ttccatcctt caaaagaaga aagaatgtct aacgaaatag gagtatattc
    12961 catttttcca ttctcgtatt tacgaaaatc cagaatctga ttgacaagac gcaaaaggat
    13021 attcacgttt cgctgaacta acaataacat tcggcgctga tcttcactca aagacgaatc
    13081 agccagtaaa tgctctaccg ggtcggcaac taatgtcagt ggagtacgaa aatcgtgaga
    13141 tatatttgtg aagaaaacca gcttggcatg agtcgcttct tccagttgat gagaaagctg
    13201 gataagctga tcccgttgct cttcgagttt atcgcgctgt tgctctactt gtttcttctg
    13261 ttcggacaac tctttattca ggcgattctt ggaacggagg gatttataga ctaccaacaa
    13321 caatcccgct actaataaaa gaataaccaa gccgccatac atcacgacct gctgcgtagc
    13381 tacacgcgac agatacccac cgatacgtcc gttcaatgtt tcaatcttct gatccagttc
    13441 cgagatatgg gtagtctgaa gttgcataac gtgcgcgttc gtgcggtcta caacggcagt
    13501 attcatgacc gtttcgcgag gataagactt cttctcaaga atattcatgg ccagttgcat
    13561 cactttgtcc ccattagtcg gataaataaa agttgcatcc agcacattgt caagcaccaa
    13621 ttcaagcccg tttcctttgc cgggcagggc atcaatgcca acaaaaatca ttaccttttc
    13681 acgtccggct ttcttcgcag cttgataggc tcccggagcg atacggtcgt tatgtgcata
    13741 taccgcatca atcttcggat gacggcgaag catactatcc atttccactt ctgccggttc
    13801 acgttcccag gcagcatccg ctttatcaat cagtttgata tccggataat tgctgatagc
    13861 agccataaat ccctgatggc gttccatggc aggggtggaa ccacccagtc cggtaagctc
    13921 cactacattc cctttccctt tcagacttga tgcgatataa tttcctaccg cacgacctat
    13981 ttcataatta tcggcaccga tataggcagt atatttatca gaaagtatct tccggtctac
    14041 aagaatgaca ggtattcctt tctgataggc ctcctccaca attggagtca tgggagccgc
    14101 ttcattggcg gaaattatca gtaaatcaac tcctttatct ataaaataat gaacatcttc
    14161 cgcctgctta cggttatcat ccgccgccga gcggatttca accgacactc catcataaaa
    14221 catcgcttcg cgaagaatct catcattcat cttgtgcctc caagagtcat cgctacattg
    14281 ggccacccca atacggaaac gaggcgcatc ctgccgacag gccgccaagc ccaaaagaca
    14341 aaacaagact gttatccact tcgtatattt catcgcttca atcattccct ttctttcgta
    14401 tatcttttgt atttctttct gtaatccaaa tttctccccc cgcattattt gcattcacca
    14461 ccgggaaata catcagttcc actttcacag ggttcagcgt atattttcca gtaaagcgtg
    14521 gaagcaaagg aaccgtaaac tgataagtac ctaccggtaa tttttcgcta aagataacag
    14581 ttttctcttt aaaatactca cgatatactt cagaacggga gaaattaaca ggttttgagg
    14641 cataactaca acctgccgga acaggaactt cgagcatcac atattgcgca ccctcctgtt
    14701 tcacctgcaa ggtaactgtc aatgtaacag gtacacccgc caccaaagag tctttttcca
    14761 aagtcacctc caccttgaaa gcatcactct gacgagcatt catcacacgc ttcattgaat
    14821 agacactata caataaaggc tcttttcccg tttttgaaat aagcagactg tcgcttgctg
    14881 tcagccgggc atgataagga aattccgtaa ttcgttgatg atccttaccg ctcacagaca
    14941 ccgacgttcc tgacatccct ccggaacctg ccagcaaatc ggtcagaaca gttgccacag
    15001 ccgaagaagc ctgatacgta ttccatccgc gctccttagt ccgcaaaata tacaattgca
    15061 tattttcttt caacttacac agggaagggt catttttaat aatccggtag gctatcaatg
    15121 tatttatcat ctgatttccc tcccaataat aagtacgccg tccgtcgtca cagtaaacac
    15181 cttccagcat atcctttttc agataaggac gtacgctatc acccacattc accgaatcca
    15241 cctgttgctt gatttcccag agaagcagct tctctttcaa gtatgaaaga ggacgataat
    15301 acttgtttct atttgccaac gagtcttctt tctgttccaa ttgccggacg aaaggttcca
    15361 ataatctgac tgccgaagaa taatccgcct ctactttcca ctcatgcaga gcatgaagta
    15421 tttctatatc ttccagtttc attcctcgat aaggacgcgt atgagcatac tccactttca
    15481 aaccattcag attcaactcc acaggataac ctgcatcttg cgccatcttc aaagcccgca
    15541 gaatatgcgc agacatccag aaagaagtat tttcagagtt cccccaccac gaccataact
    15601 gatgtttgtt ctgatgattc gtcagtcgat ggatgatagg tcgaattgct ttatctactt
    15661 tcaccttttc acccttactc tgcatatact gttggtaagc caacaaaccg attaacttgg
    15721 atgccagctg ctcattgcac aaatatttgt atcctgtcaa gtaattcact gattctttat
    15781 agatgtccaa ctgattgtca gtgatactca ccatcacttc ttcatcctcg ccggattgca
    15841 ctttaaccgt ctttgcatcg gacagaatac ccaatgtgcc ctccgccaat tcagttccct
    15901 gtgccagtat cggaatcgta tattcctctc catcctgata gccatcgtcg cgagtgaaaa
    15961 gatagctgat ggtcacgcta tcggcatgaa ctgcctgcat cggcactgtt tcatgaaatc
    16021 cctccatgaa actcacttcc tgccgtttca acgtatccgt tccgacgcag aactgtgtct
    16081 ttccggctat gtgctgccca tccagataat tgcggatagt cccgaccacc gtactctgat
    16141 ccccctccac caagaagcgg ggagttttca actccgccat caacggtttg taagagcgga
    16201 cgaaacgtcg gaaagtaccc gtctgcaaac gacggttcat gccataaacg acagtttccc
    16261 atttcgtcac attatcgggg aaagttgttt caaactgtac c
//
