LOCUS       c00045_gnlPro..        16565 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FDKACNMC_45.
ACCESSION   c00045_gnlPro..
VERSION     c00045_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 22:25:06
            Original ID  :: gnl|Prokka|FDKACNMC_45
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16565
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16565
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3144:6705](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3145..6705
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16565
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16565
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(573..1727)
                     /locus_tag="ctg45_1"
                     /transl_table=11
                     /translation="MALASGETNYMAPASARQMASDLALLPMWYAEAGSAVLAPSAYNA
                     DFLKTKSELLGMDVALLTEPEVADGKDRKFSPWGWDPALRKRLMTLGAGQTELPSADYM
                     NILREHSHRLQAVKLLPGLRLNEYFCGESFYLSTLAECSAFVEGREACLLKAPLSGSGK
                     GLNWCKGIFTTFISGWCARVAASQGGVVGEPIYNKVEDFAMEFYADGRGRVVFAGYSVF
                     HTGGSGMYAGNDLLSDEKILQKLSAYVPQEEFIRLRTRLEEELSALFGGFYHGYLGVDM
                     MICHFPDEAPVYRIHPCVEINLRMNMGVVAWLLTDRYLAADAEGVFRIDYYPLAGQALE
                     EHRQMSASFPLSVENNRVCAGYLPLVPVTPQSRYRAFLLLTLPQ"
     CDS             1907..3112
                     /locus_tag="ctg45_2"
                     /transl_table=11
                     /translation="LPAEKQRNEMESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGI
                     KGTRGVGKTTFLLQYAKEKFGNDRSCLFINMNNFYFSGHSIVDFANEFQKRGGKVLLID
                     QVFKHPEWSKELRMCYDRFPNLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREYL
                     NLQTGMKFRAYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENL
                     LKTMNMMVEVDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDIQTSRATVMN
                     YIKYLADARLINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFVNSLW
                     KDHKVHKGDKNVSFMVDEVMPFKICQEGAKIKNNPNVTYALHKAEIGRGNQIPLWMFGF
                     LY"
     CDS             3145..6705
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_3"
                     /sec_met_domain="PFOR_II (E-value: 6.1e-19, bitscore: 57.9,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 7.1e-83, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 7.8e-32, bitscore: 100.3,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.4e-12, bitscore:
                     37.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 2.4e-12, bitscore: 37.3,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 4.6e-08, bitscore: 22.4,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 2.5e-05, bitscore: 14.4,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 1.2e-25, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMNPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKTIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQILSVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIAMEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLTVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNAENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKVFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKTKQHLVDIKSNVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTTNENGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARIVKLFNEILAADNASPEAKEVLKAWIENMYDADKTKE
                     LAPQVKAVIEEGLSHGCPICKELKGLTQYLVKRSQWIIGGDGASYDIGYGGLDHVIASG
                     KDVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQI
                     AMGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLW
                     RYNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPTEAEELFKAAEENAK
                     WRYNSYKRLARENWGADTAE"
     CDS             6830..7018
                     /locus_tag="ctg45_4"
                     /transl_table=11
                     /translation="MIGFVIWIIGLILTFRAAIEIWNINAAVEKRLIAIVLIVLTSWLG
                     LLFYYFYGKERMAGWLK"
     CDS             complement(7029..7889)
                     /locus_tag="ctg45_5"
                     /transl_table=11
                     /translation="MNKIKMIAAMFIAGILLTFVSCGDNGKSKKISIAYANWSEGIAMT
                     NLAKAIFEDQGYDVKLLNADLAPIFTSISRKKADVFMDVWMPVTMEDYMKQYGDKLEVI
                     GDIYDGARIGLVVPDYVTINSIEELNAEKERFSGQIVGIDAGAGIMKATDQAIKDYGLD
                     YKLMTSSGPAMTASLKKAIDKKDWIVVTGWTPHWMFDRFKLKVLQDPKLIYGNTESIHT
                     IAWKGFSEKDPFAAELLGNIRLTDAEISSLMTALEEAQTTERQAARQWMEEHQELVNSW
                     IPEKD"
     CDS             complement(7917..8747)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 91.7; E-value: 1.6e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg45_6"
                     /sec_met_domain="BPD_transp_1 (E-value: 2.9e-29, bitscore:
                     91.7, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIETAINWLTEHFASFFDALSMGIGGFIDGFQHVLFGIP
                     FYITIAVLAALAWFKSGKGTAVFTLLGLLLIYGMGFWEETMQTLALVLSSTCLALLLGV
                     PLGIWTANSDRCNKIMRPVLDFMQTMPAFVYLIPAVLFFGLGTVPGAFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATPWQLLYKVQLPLALPTILTGINQTIMMSLSMVVIA
                     AMISAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIVLDRITQGMADNRKSKKK"
     CDS             complement(8744..9970)
                     /locus_tag="ctg45_7"
                     /transl_table=11
                     /translation="MSKIEIKDLYLVFGNEKQKALKMLKEGKTKSEILKATGCTVAVKD
                     ANLSINEGEIFVIMGLSGSGKSTLLRCINRLIRPTSGEVIINGTDIAKVSDKELLQIRR
                     KELAMVFQNFGLLPHRSVLHNIAFGLELQGVKKGEREQKAMESMQLVGLKGYENQMVSE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLTLQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEIVQIGTSEEILTEPANAYVERFVENVDRSKIITASSVMVD
                     KPIVARLKKEGPEVLIRKMRERNLTVLPVVDSNNLLVGEVRLNDLLKLRKEQIRSIESV
                     VRHEVHSVLGDTVLEDILPLMTKTNSPIWVVNENREFEGVVPLSSLIIEVTGKDKEEIN
                     EIIQNAIEL"
     CDS             10443..11729
                     /locus_tag="ctg45_8"
                     /transl_table=11
                     /translation="MFNRAITIFLGKDNCHYTTKEKQTGTATLDDKSQVQFLSKKNPKM
                     PFFYSRRNLYMIGFLLAFIVTLLEFIRGRHQNFMVFSDATQFFWQGISPYTTEFVEAHG
                     RYFLYSPVFTVLFAPFAYLPAWLGPFAWNLFNYSLFFMAIFTLPQQFTQQQKCRMFLFL
                     LLILGQSLLSFQYNITVAYLFLFAYTLLEKDRGFLAVLLIMISGCTKVYGIFELALLLC
                     YPHVWRNFGYAVTMGIVLLALPLIKIAPADLLPYYEEWCHSLAVHQSAGAYDSFFYARP
                     IAAWTLPHFRALQIGMLGLLTLLFLGNFRKWSSFAFRAQALGILMGWVVLLSDSAEKHT
                     YIIALAGFMLWYWSRPTRTATDKILFWCCFVLLCIVPIDIFVPVPIRDFITRTLWLHVW
                     VFFIVWIRMIWLTFLASFIHPRATNVLSD"
     CDS             complement(11692..12024)
                     /locus_tag="ctg45_9"
                     /transl_table=11
                     /translation="MKDYKVDKESFSESFRKEVYEVVSQIPVGKVSTYGGIALLLGAPQ
                     CSRMVGRALKEVPDELSIPCHRVVNSTGRLVPGWVEQKQLLLAEEVSFKANGCVNLKEH
                     LWHVDE"
     CDS             complement(12052..14805)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 64.3; E-value: 4.2e-20)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg45_10"
                     /sec_met_domain="Peripla_BP_1 (E-value: 7.4e-21, bitscore:
                     64.3, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTMRYLKWMLVLFGLIGMTACRQDTPRFRIGVAQCSDDSWRHKM
                     NDEILREAMFYNGVSVEIRSAGDDNSKQAEDVHYFMDEGVDLLIISANEAAPMTPIVEE
                     AYQKGIPVILVDRKILSDKYTAYIGADNYEIGRSVGNYIASSLKGKGNIVELTGLSGST
                     PAMERHQGFMAAISKFPDIKLIDKADAAWERGPAEIEMDSMLRRHPKIDAVYAHNDRIA
                     PGAYQAAKMAGREKEMIFVGIDALPGKGNGLELVLDSVLDATFIYPTNGDKVLQLAMDI
                     LEKKPYPKETVMNTAVVDRTNAHVMQLQTTHISELDKKIETLNGRIGGYLSQVATQQVV
                     LYGSLIILLLVAGLLLVVYKSLRSKNRLNKELFKQKQQLEEQRDKLEEQRDQLIQLSHQ
                     LEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADKTLSGDQHRMLMLIQRNVNILLR
                     LVNQILDFRKYENGKMEYTPVTVDVLSSFEGWNESFQAAARKKHIHFSFDSMPDTDYHT
                     LADMEKLERIYFNLLSNAFKFTPENGKIAIRLSSLSKEDKRWIRFTVANTGSMISAEHI
                     RNVFDRFYKIDMHHTGSGIGLALVKAFVEMHGGMISVESDEKQGTVFTVELPIQSCEAV
                     AAEPDTTLVSADSRTTDVLLAEEEELEKGYDSSKPSVLIIDDNEDIRSYVHTLLHTDYT
                     VIEAADGSEGIRKAMKYVPDLIISDVMMPGIDGIECCRRLKSELQTCHIPVILLTACSL
                     DEQRIQGYDGGADSYISKPFSSQLLLARVRNLIDSHRRLKQFFGDGQTLAKEDVCDMDK
                     DFVERFKSLIEEKMGDSGLNVEDLGKDMGLSRVQLYRKIKSLTNYSPNELLRIARLKKA
                     ASLLASSDMTVAEIGYEVGFSSPSYFAKCYKEQFGESPTDFLKRKG"
     CDS             complement(15138..16364)
                     /locus_tag="ctg45_11"
                     /transl_table=11
                     /translation="MFFFLIVPLFLALFYKPIAYLCGRFLNNKSKRENYFMKHISNFLR
                     SKSWNVFLFLYLALPLFAQKEYKIDQVSVVNVGDGRLLFQELKTEKALNGEHRIIDGYH
                     SAYVLASFKDGFYDGGYKEYVDNILITEGSYKEGRKDGLFKINSKFDGKLKEEKSYKEG
                     KLDGTSKSYFTTGKVESERNFRMGKEHGKQLSYESDGTLRKEHNYKDGKQVGKQYTFLK
                     GTYDLYETVYFNEEGFQDGEYSSVFTFGSPRILGSYKNGKKNGRWTTFAESGDTLMIET
                     YLDGKEDGLHVSFANGSGVRQKEYYMKNDRKDGLYREYNLENGELRYEATYQAGRLHGK
                     ERRLIVSNRFDYWETSTYVNGRQNGPFEARYVKNDQLRECGEYKNGHRVGRWKRYTIDG
                     KLEKEWDEN"
ORIGIN
        1 gtaaactaat tcagttataa caaacgaagt tgtcaactaa aaccagtaca catcaccaat
       61 tccaatttag cagtatcttc aaagagtttc cattgcttga aaccagagtt tcatcggtgt
      121 gaaactgtag tttcatcggt gagaaactag agtttcatac gcttgaaact ttagttccaa
      181 acgctcgaaa ctatctgaaa ctactgttga tttgattgac ttaaccgcat gttccaatca
      241 cattgaacgc atcagctact tcaatagtac tgctctctct gaaaacatta aatcatatat
      301 cagtcaataa tacataaatt atcagtcctt aatacttgat ttctcaatta ttaatatctg
      361 agaaatcaaa cgttaacagt tgagacatca gatattaaca tcctgtaaat caaagaataa
      421 cacagtaaaa acggtattta tcaggacgat gcagagtgag agcaagtcct tgctctcact
      481 ctgctaccac tggatctcta acagctaaaa catcgatgaa taaagggata cagacgaact
      541 gttagagcat gagagcaaaa gcactatctt tttcactggg ggagagtaag caaaagaaac
      601 gcacgatacc ggctttgagg cgtcaccggt actaacggca aatatccggc acacacccga
      661 ttattctcta cggacaaagg gaacgaagcc gacatctgcc gatgttcctc caaagcctga
      721 ccggctaaag gataataatc aatccgaaaa actccttccg catccgcagc caaataacga
      781 tccgtcaaga gccatgccac cacccccata ttcattcgca gattaatttc gacacaagga
      841 tgaatccggt aaacaggcgc ttcatccgga aaatgacaaa tcatcatatc cactcccaag
      901 tatccatgat aaaagccacc gaacaaagct gacaattctt cttccaaacg agtccgcagc
      961 ctgataaatt cttcttgtgg cacataagcc gatagtttct gcagaatctt ctcgtcagac
     1021 agcaagtcat tccctgcata catcccactc ccacccgtgt ggaagaccga atatccggca
     1081 aaaacaaccc ttcctctccc gtcagcataa aactccatag cgaaatcttc caccttatta
     1141 tatataggtt cgcctaccac cccaccctga gaagcagcga cacgggcaca ccaaccggaa
     1201 ataaaagtag taaatatgcc tttacaccaa ttcaatcctt tcccgcttcc ggaaagcgga
     1261 gcttttaaca agcacgcttc ccgcccttcg acgaacgcac tgcactccgc caaagtactc
     1321 aaataaaaag attctccaca gaagtattca ttcaaccgca acccaggcaa caactttacc
     1381 gcctgcagac gatgcgaatg ctctctcaga atattcatat aatccgcaga aggcagctcc
     1441 gtctgacctg cccccaatgt catcaaacgc ttccgcaaag cagggtccca cccccacgga
     1501 gagaacttcc ggtctttacc gtcagccact tccggttccg tcaacaaggc cacatccatg
     1561 cccaaaagtt cactctttgt tttcaggaag tccgcattat aagcagacgg tgcaagcacc
     1621 gcacttcccg cttcggcata ccacatagga agcaacgcca ggtcactcgc catctgtcgg
     1681 gcggaagccg gcgccatata gttcgtctca ccgcttgcca acgccatatc atgctccgga
     1741 ttgaatatat aaacaggtct tttcgtcatg tcaaagatgg attcaacaca ttattctgca
     1801 aatatataca ggaaataatc aggaacttac acaataaaga gaaacttata aattaaagca
     1861 catttttgct atctctactt tgcaaatcct aaaaaaagca ctatatttgc cagccgaaaa
     1921 acaaagaaac gaaatggaat cattctatcg cacacacgcc tacctcgttg agcacaccaa
     1981 tgcccccgtt cgccgcgatc ttatggacga gatcgactgg agcgaccgcc tgattggtat
     2041 caaagggaca cgtggcgtag gaaaaaccac tttccttctc caatacgcca aagaaaaatt
     2101 tgggaacgac cgctcctgcc tgttcatcaa catgaacaac ttctacttct ctggccacag
     2161 cattgtagac tttgctaacg aatttcagaa acgtggcgga aaagtattgt tgatcgacca
     2221 ggtgttcaaa catccggaat ggagcaaaga gttacgcatg tgttacgacc gttttcctaa
     2281 cctgaaaatt gtcttcaccg gctcgtccgt gatgcgactg aaagaagaaa atcttgaatt
     2341 acgtgatatc gccaagagct ataacctgcg cggattttct tttcgcgaat acctgaactt
     2401 acagacaggc atgaaattca gggcatacag cctcgaagaa attcttagca ctcacgaaca
     2461 gattgccaaa ggagtactct ctaaagttcg tccgctggat tacttccagg attacctgca
     2521 tcatgggttc tatccgttct tcctcgagaa gcgtaacttc tcggagaatt tgctgaaaac
     2581 gatgaacatg atggtggaag tagatatact tctcatcaaa caaattgaac tgaaatatct
     2641 ttcaaagata aaaaaattac tatatttgct cgctgtcgac gggccgaaag ctccaaatgt
     2701 gagccaactg gcaagcgaca tacagacatc tcgcgccacg gtgatgaact atatcaagta
     2761 tctggcagat gcgcgactca ttaatctggt ttatccgaaa ggggaagaat tccctaaaaa
     2821 accttcgaag ataatgatgc acaactccaa cctgatgtat tccatctacc cggtgaaagt
     2881 ggaggagcag gatgtgctcg acactttctt tgtgaattct ttatggaaag accataaggt
     2941 acataaagga gataaaaacg tctcttttat ggtggacgaa gtaatgccgt tcaaaatttg
     3001 ccaggaagga gcaaagatca agaacaatcc gaatgtgacg tacgcgttgc ataaggctga
     3061 aataggtcgg ggcaaccaga tacctctctg gatgttcggc tttttatatt aaaagattta
     3121 tttacttaaa tatttaattt agttatgact aaacagaaga aattcatcac ttgtgatggt
     3181 aaccaggctg cagcgcatat ctcgtatatg ttctctgaag tagctgctat ctaccccatc
     3241 actccttctt cgactatggc tgagtacgta gacgaatggg ctgccgcagg acgtaagaac
     3301 atcttcggcg aaacagtatt ggtacaggaa atgcaatctg aaggtggtgc tgccggtgca
     3361 gttcacggtt ctcttcaggc tggtgcgttg actactactt acactgcttc tcagggtctt
     3421 ctcctgatga tccctaacat gtacaaaatt gccggtgagt tcttgccttg cgtattccat
     3481 gtatctgctc gtacattggc ttctcacgca ttgtgtatct tcggtgacca ccaagacgta
     3541 atgtcagctc gtcagactgg ctttgcgatg ttggctgaag gctctgtaca ggaagttatg
     3601 gatttggctg gtgttgctca cttggctact atcaaatctc gtgttccgtt catgaacttc
     3661 ttcgatggtt tccgtacatc tcacgaaatc cagaagattg aaatgttgga aaatgatgat
     3721 cttgctccgc tgattgatca ggaagctttg gctgaattcc gtgcccgcgc actgaatccg
     3781 atgaatccgg ttgctcgtgg tatggctgaa aatcctgacc atttcttcca acatcgtgaa
     3841 tcatgcaaca actactatga agcagttcct gctatcgtag aagaatacat gaatgaaatt
     3901 tctaagatta caggtcgtaa atacggtttg ttcgattatt atggtgcaga agatgcagaa
     3961 cgcgtaatta tcgctatggg ttctgtaaca gaagctgccc gcgaagctat cgaccacttg
     4021 gtagcaaatg gcgaaaaagt gggtatggtt gccgtacacc tgtatcgtcc gttctctgct
     4081 aaacacttcc tggctgctgt acctaagact gccaagacta tcgcagttct tgaccgtact
     4141 aaagaaccgg gcgctaacgg cgaacctctt taccttgacg ttaaagactg cttctacggc
     4201 gcagaaaatg ctccggttat cgttggcggt cgctacggtt tgggttcaaa agatactact
     4261 cctgctcaaa ttctttcagt attcgaaaac ttggctatgc caatgccgaa gaaccacttc
     4321 actatcggta tcgtagacga cgttacgttc acttctcttc ctcagaaaga agaaatcgct
     4381 ctgggcggtg aaggtatgtt cgaagctaaa ttctacggtc tgggtgctga cggtactgta
     4441 ggtgccaaca agaactctgt taagattatc ggtgacaaca ccgacaaaca ctgtcaggct
     4501 tacttctctt acgactccaa gaagtcgggt ggtttcactt gttctcactt gcgtttcggt
     4561 gatactccga tccgttctac ttacttggta aatactccga acttcgttgc ttgtcacgtt
     4621 caggcttacc tgcacatgta cgacgtaaca cgtggtttgc gtaagaacgg ttctttcttg
     4681 ctgaatacca tctgggaagg cgaagaactg gctaagaacc tgcctaacaa ggtgaagaaa
     4741 tactttgcac agaacaacat ctctgtatac tatatcaacg caactcagat tgcaatggaa
     4801 attggtttgg gcaaccgtac caatacaatc cttcagtctg cattcttccg tatcacaggc
     4861 gtaatccctg tagatcaagc tgttgaacag atgaagaaat tcatcgttaa gtcttacggc
     4921 aagaagggtg aagacgttgt taacaagaac tacgctgctg tagaccgcgg tggtgaatac
     4981 aagactctga ctgtcgatcc tgcttgggct aacctgccgg atgatgcaaa agcagaaaac
     5041 aatgatcctg ctttcatcaa cgaagtagtt cgtccgatca atgcacagga cggtgacttg
     5101 ctgccggtat ctgcattcaa gggtatcgaa gacggtactt ggtatcaagg tacttccaaa
     5161 tacgaaaaac gtggtgtagc tgcattcgtt cccgaatgga atgctgaaaa ctgtattcag
     5221 tgtaacaagt gtgcttacgt ttgtcctcac gcttctatcc gtccgttcgt actcgatgct
     5281 gaagagcaga agggtgctaa gttcgaacaa ttgaaagcag taggtaaagt attcgacggt
     5341 atgacattcc gtatccaggt tgacgttctc gactgtctgg gttgcggtaa ctgtgctgac
     5401 atctgtccgg gtaatccgaa gaagggtggc aaagcattga caatgaaaca cctcgaaagc
     5461 caattggctg aagctgacaa ctggacttac tgtgctgaaa acgtgaagac taaacaacat
     5521 cttgttgata tcaagtctaa cgtgaagaac tcacagttcg ctactccgtt gtttgagttc
     5581 tctggtgctt gctctggttg tggtgaaact ccgtatgtga aattgatttc tcaattgttc
     5641 ggtgaccgtg aaatggttgc taacgctacc ggatgttctt ctatctactc tggttcagtt
     5701 ccttctactc cgtatactac gaacgaaaac ggtcacggtc ctgcttgggc taactcactg
     5761 ttcgaagact tctgtgaatt cggtttgggt atggaattgg ctaacgaaaa gatgcgtgct
     5821 cgtatcgtga agttattcaa cgaaatcctt gctgccgaca acgcttcacc tgaagcaaaa
     5881 gaagtgctga aagcatggat tgaaaacatg tacgatgctg acaagactaa agaattggct
     5941 ccccaagtga aagcagtgat tgaagaaggt ctttctcacg gatgtcctat ttgcaaagaa
     6001 ctgaaaggac tgactcaata tcttgtaaaa cgcagccaat ggatcattgg tggtgacggt
     6061 gcttcttacg atatcggtta tggtggtctt gaccatgtaa tcgcttccgg taaggacgtt
     6121 aacatcctcg ttctggatac tgaagtttac tctaacacag gtggtcagtc ttctaaggct
     6181 actccggtag gtgctatcgc taagttcgct gctgctggta agcgcgtacg taagaaagac
     6241 ctcggtctga tggctactac ttacggttat gtatatgttg cacagatcgc tatgggtgct
     6301 gaccaggctc agactctgaa agctatccgc gaagctgaag catatcccgg accatcactc
     6361 atcatcgctt acgctccgtg tatcaaccac ggtctgaaag ccggtatggg taagagccag
     6421 gaagaagaag aaaaagctgt taagtgcggt tactggcact tgtggcgtta caacccagct
     6481 ttggaagaag aaggcaagaa cccattccaa ttggatagca aagaaccgaa ctgggaagat
     6541 ttccaaggtt tcttgaaggg tgaagttcgt tacgcttctg taatgaaaca atatcctact
     6601 gaagctgaag aactgtttaa agctgctgaa gaaaacgcta aatggcgtta caacagctac
     6661 aaacgtcttg ccagagaaaa ctggggagct gatacagctg aataataagt agaaatactt
     6721 tgtacataat aaaaggcagg aatcctggaa acagattcct gccttttttg tttatatctt
     6781 agaagtaacg attacttctc acgaagatat tcattaaaac tctaaagata tgatcggatt
     6841 tgttatttgg attatcggtt tgatactgac tttcagagct gccatagaga tttggaatat
     6901 aaatgcggct gtagagaaaa gacttatagc gattgtatta atcgttctta ccagctggct
     6961 gggactactt ttctactact tctatggtaa agaaagaatg gcgggatggt tgaagtagtg
     7021 tttgcatatc aatctttctc aggaatccaa ctgttcacca gttcctgatg ttcttccatc
     7081 cattgacggg cagcctgtct ttccgttgtc tgcgcctctt ccagagcagt cattaaggag
     7141 ctgatttccg catctgtcag acgaatgttg cccaaaagtt cggcagcaaa agggtctttc
     7201 tcgctaaaac ctttccatgc tatggtatga atggattccg tatttccata tatcagcttc
     7261 gggtcctgaa gaactttcag cttgaaacgg tcgaacatcc agtgaggcgt ccatcccgtc
     7321 acgacaatcc agtctttctt atcaatcgct ttctttaggg aagcagtcat ggcaggtccg
     7381 ctcgaagtca tcagtttata atccaatcca tagtctttga tggcctgatc ggtagctttc
     7441 ataataccgg ctccggcatc aataccgaca atctgaccgg agaaacgttc cttttccgcg
     7501 ttcagttctt cgattgagtt gatcgtaacg taatccggaa ccaccagccc gatacgggca
     7561 ccatcataaa tatccccgat aacttcgagt ttatccccgt attgtttcat ataatcttcc
     7621 atagtgacag gcatccagac atccataaat acgtctgctt tcttacggga gatagaggta
     7681 aatataggtg caaggtcggc attcagcaac tttacatcgt acccctgatc ttcaaaaatc
     7741 gctttggcaa ggtttgtcat tgcaatacct tccgaccagt tggcataagc gatacttatc
     7801 ttcttactct ttccgttgtc tccgcaggaa acgaaggtta agagtatgcc ggcaataaac
     7861 attgccgcaa tcatttttat cttattcatt gattattcct ttctttggtg tgattcttat
     7921 ttctttttac tttttctgtt atctgccata ccctgagtga tgcggtccag cacgatcgcc
     7981 aatatcacga ctgcgatacc gccttcaaat ccgagtccga ttttcatttg ggtgatacct
     8041 ttcagcacga tttctcccaa tcctccggca gaaatcatgg cagcaatcac taccatcgaa
     8101 agtgacatca tgatcgtctg gttgattccc gtcagaatag taggcaacgc caaaggcaat
     8161 tgcaccttat aaagaagctg ccagggagta gctccaaaag agcgggaggc ttctactacg
     8221 tttttaggaa cctgacgaat gcccagaccg gtcagacgaa ccacaggagg cattgcaaag
     8281 atgatggtgg caaaagctcc cggcacagtt cccaatccga agaatagaac ggcaggaatc
     8341 agatagacaa aggcaggcat tgtctgcata aagtcgagga cagggcgcat tatcttgtta
     8401 caacgatcac tgttggcagt ccagattccc aacggaacgc ctaaaagcaa tgccagacaa
     8461 gtggaagaaa gtaccaatgc caatgtctgc atcgtttctt cccaaaagcc catgccgtaa
     8521 ataagcaata aacccaagag ggtaaatacg gctgtcccct tacccgactt aaaccaggcg
     8581 agcgcagcca gcactgcaat tgtgatataa aaaggtattc caaacagtac gtgctgaaaa
     8641 ccgtctatga atcctccgat ccccatgctg agagcatcaa aaaaggaagc aaaatgttct
     8701 gtgagccaat taatggcagt ctctatatat tgtccgatat ttatcataat tctattgcgt
     8761 tttgaatgat ttcattaatt tcttctttat cttttcccgt tacttcgatg atcaatgagg
     8821 aaagtggcac tacgccttca aactcccgat tctcatttac gacccagatt ggcgagttcg
     8881 tttttgtcat caacggaaga atatcttcca gcaccgtatc acccagcact gaatgaactt
     8941 catgccttac tacggactcg atggagcgga tttgctcttt tcgtagtttc agcaagtcat
     9001 tcaaccgcac ctctcctact aacagattat tggaatcgac taccggaaga acggtcagat
     9061 tccgttcgcg catcttacgg atcagcacct ccgggccttc tttcttcaaa cgtgccacta
     9121 tgggtttatc taccataaca gaggaagctg ttataatctt gcttcgatct acattctcca
     9181 caaatcgttc tacataagcg ttggcaggtt cggtcaggat ttcttccgat gtaccgattt
     9241 gtacaatttc tccatccttc atgatagcaa tccggtcacc caatttaatc gcttcactca
     9301 ggtcgtgagt aataaagaca atcgtttttt tcatcttcga ctgcaaagtc agcagttcat
     9361 cctgcatctg cacacggatc aaaggatcga gtgccgagaa ggcctcatcc atcaacagga
     9421 cttcgggatt attggccaaa gcccgcgcca gcccgacacg ctgctgcatc ccacccgaca
     9481 gttcacttac catctgattc tcgtagcctt tcagccccac cagttgcata ctttccatcg
     9541 ctttctgctc ccgttctccc ttttttactc cctgtagttc gagcccgaaa gctatattat
     9601 gcaagacaga acggtgagga agcagaccga agttctgaaa gaccatagcc agttctttcc
     9661 ggcgaatctg caacagttcc ttatccgaca ctttggctat gtctgttcca ttgataatca
     9721 cttctccgga agtagggcgt atcaaacggt tgatgcagcg gagtaaagtg gactttccac
     9781 taccggacag ccccataatg acgaatattt cgccttcatt aatggaaaga ttcgcatctt
     9841 tcaccgcaac tgtacatccg gtcgctttca atatttcact ttttgtttta ccttctttca
     9901 acatcttcaa agccttctgc ttctcattgc caaaaaccag atagagatct ttaatttcta
     9961 ttttactcat acaataaaat ggtttaggtt attaaaataa tatacacagc aagacaagaa
    10021 caaacgataa caggaatctt tctttatatc gtataaagtt ctgatttaaa taagggacaa
    10081 ataacaatga atcccgaaat aattaataaa atgattattg acagactgag taattaaaaa
    10141 aggaatagaa tttgataaga taatcctttc aacgaatagc aaaaaatagc atttttatgt
    10201 ataaaaacag cctgttccag tatcttgctg gcacaaagat acaaaaaacg gattaaacat
    10261 acaaattata ttcaaaatcc ggggcataca gagggcttta tttgtaatga tatggaaagt
    10321 ttccgggtaa tattccccta tcactcagca aaatagaaca aaccggcaga taaatataaa
    10381 ataagtttga atatttcact taaacaccgt atatttggcg tcaataacta aactagattt
    10441 atatgttcaa cagggctatt acaattttcc tggggaagga taattgtcat tacacaacaa
    10501 aagaaaaaca aacaggtact gccacactag acgacaaaag ccaagtacag ttccttagta
    10561 aaaagaaccc caaaatgccg tttttctata gccggcggaa tctctacatg ataggtttcc
    10621 tgctcgcttt tatagtgact ctgctcgaat ttatacgagg acggcatcaa aactttatgg
    10681 tcttctcgga cgctactcaa ttcttctggc aaggcatcag cccatacaca actgaatttg
    10741 tagaagctca cggacgctac ttcctttatt ctccagtttt cacggtattg ttcgctccgt
    10801 ttgcgtatct gcctgcatgg ctgggacctt tcgcgtggaa tctattcaat tattcgctgt
    10861 tctttatggc gatcttcacg ctgccccaac aattcaccca gcagcagaaa tgccgtatgt
    10921 tcctttttct gttactgatt ttaggacaaa gtttactttc atttcagtat aacataacgg
    10981 tagcctattt attcttattc gcctatacgt tattggaaaa agaccgtgga tttctggctg
    11041 ttctgttaat catgatttcg ggatgtacca aagtatatgg aattttcgaa ctggcattgt
    11101 tgctgtgcta tcctcacgta tggcgtaact ttggctatgc cgttacaatg ggcattgtat
    11161 tgcttgcatt accgttaata aaaatagctc ctgcagattt gctcccctat tatgaagaat
    11221 ggtgccatag tcttgctgtt catcagtccg ccggagctta tgattcattt ttctatgccc
    11281 gccccattgc agcatggaca ttgccacact tccgtgcact tcagatagga atgctcggct
    11341 tgctgactct gctctttttg gggaatttcc gcaaatggtc gtcttttgcc ttccgtgccc
    11401 aggctttggg cattctcatg ggctgggtag tattactgag tgactccgcc gagaagcata
    11461 cctatattat cgcattggca ggtttcatgc tctggtattg gagcagacca acacgtaccg
    11521 caacagacaa gattctattt tggtgctgtt ttgtgctgtt atgtatcgtt cctatcgaca
    11581 tattcgtccc tgtacccatc agagatttca ttaccaggac cttatggctt catgtatggg
    11641 ttttctttat tgtatggata cggatgatat ggcttacctt ccttgcatcc ttcattcatc
    11701 cacgtgccac aaatgttctt tcagattaac gcatccgtta gctttgaaag aaacttcttc
    11761 tgccagcaag agttgttttt gttccaccca accgggcacc agccttccgg tggaatttac
    11821 aactctatgg cagggaatgg ataattcatc cggcacttct ttcaatgcac gtcccaccat
    11881 ccgcgagcat tggggtgccc ccaacagcaa agcaatacct ccataagtag atacttttcc
    11941 cacaggtatc tgggatacga cttcgtacac ttccttccga aaggattcgg aaaagctctc
    12001 tttatctact ttataatctt tcatatatcc ctctttacga tatcaatgaa atcatccttt
    12061 ccttttcagg aaatctgtcg ggctctctcc aaactgctct ttatagcact tggcgaaata
    12121 agaaggtgaa ctgaaaccga cttcataacc aatctccgct acggtcatgt ccgaagaagc
    12181 aagcaaagaa gctgccttct tcaaacgggc gatacggagc aattcattcg gagagtagtt
    12241 agtcaatgat ttaatcttgc gataaagctg cacacggctt agtcccatgt ctttgcccaa
    12301 gtcctccaca ttcaaaccgg agtctcccat tttctcttca atcaatgact tgaatctttc
    12361 tacaaaatcc ttgtccatat cgcagacatc ttcttttgcc aatgtctgcc cgtcaccaaa
    12421 gaactgtttc agacgacggt gagaatcgat cagattgcgg acacgtgcca gcaacagctg
    12481 tgaactgaac ggctttgaaa tataagaatc cgcaccaccg tcatatccct gaatacgctg
    12541 ttcgtccagt gaacacgctg tcagcagaat aaccggaata tgacaggtct gtaactcact
    12601 tttcagccgg cggcaacatt caatgccatc aatgcccggc atcatcacat cagaaatgat
    12661 caggtccgga acatacttca tagccttacg gattccttcg gagccgtctg ccgcttcaat
    12721 caccgtatag tctgtatgca acagcgtatg gacatacgaa cggatatcct cattatcatc
    12781 aataatcagt acggacggtt tggaagagtc atatcctttt tccagttctt cctcttctgc
    12841 caatagaaca tctgttgtac gggaatccgc agaaacaagg gtggtatccg gttcggcagc
    12901 aacagcctca caagactgta taggcagttc aacggtaaag accgtgccct gtttctcatc
    12961 gctctctacg gagatcatac caccgtgcat ttctacgaag gcttttacca atgccagtcc
    13021 gattcccgaa ccggtatggt gcatatcaat cttatagaaa cggtcgaata cattgcggat
    13081 atgttcggca gaaatcatgg aaccggtatt tgccaccgtg aaacgtatcc atcgcttgtc
    13141 ctctttacta agggaagaca gacggatggc tattttcccg ttttccggtg taaacttaaa
    13201 ggcattggac aggagattga aataaatacg ttccagcttc tccatgtctg ccagtgtatg
    13261 ataatccgta tccggcatac tatcaaaaga aaaatggata tgcttcttac gggctgccgc
    13321 ctgaaaagac tcattccatc cttcgaaaga agaaaggaca tccaccgtaa ccggagtata
    13381 ttccatcttg ccgttttcat atttacggaa atccagaatc tgattgacca gacgcagaag
    13441 aatgttcaca ttccgctgaa tcagcatgag catccggtgc tgatctccgc tcagtgtctt
    13501 gtccgccaac aaatgttcta ccgggtcggc aaccaatgtc aacggagtac ggaagtcgtg
    13561 agaaatattg gtgaaaaaga ccagcttggc atgggtagct tcttccagtt gatgagagag
    13621 ctgtatcaat tggtcacgct gttcttccag tttgtcacgc tgctcttcca attgctgctt
    13681 ctgcttaaaa agctctttat tcaagcgatt cttagagcgg agtgatttat aaacgaccaa
    13741 taataagccg gctaccaata aaaggataat cagactgccg tataaaacga cctgttgtgt
    13801 agctacctga gagagatagc caccgatacg tccgttgagc gtttcaatct ttttgtcgag
    13861 ttcggaaatg tgtgtggtct gcaactgcat gacgtgtgcg ttggtacggt ccacaacagc
    13921 ggtattcatc accgtttctt tgggataggg tttcttctcc agaatgtcca tagccagttg
    13981 cagtacctta tcgccattgg tcggatagat aaaggtggca tccagcacac tgtccagtac
    14041 cagttccagt ccgtttccct tacccggcaa ggcatctatg ccgacaaaaa tcatttcctt
    14101 ctcccgccct gccatctttg ctgcctgata ggcacccgga gcgatacggt cattatgggc
    14161 atacacagca tcaatcttag gatgcctccg aagcatacta tccatttcta tctctgccgg
    14221 accacgttcc cacgcagcat ccgctttatc aatcagcttt atatccggga atttactgat
    14281 ggcagccata aatccctgat gccgttccat tgcaggagtc gaaccgctca atcctgtcag
    14341 ttctactata tttcccttcc ctttcagact ggaggcaata tagtttccta ccgaacgacc
    14401 gatttcataa ttatcggctc cgatataggc agtatattta tccgaaagaa tcttccggtc
    14461 tacaagaata acggggatgc ctttctgata agcttcttct acaatcggag tcataggagc
    14521 agcttcgtta gcggaaataa tcagcagatc gactccttcg tccataaaat aatggacatc
    14581 ttccgcctgc ttactgttat catcccctgc cgaacggatt tccaccgaaa caccattata
    14641 aaacatcgct tcccgaagaa tctcatcatt catcttatgt cgccatgaat catcgctgca
    14701 ttgagccacc ccaatacgaa aacggggtgt atcctgccgg caagccgtca tcccgattaa
    14761 accaaacagc accagcatcc acttcagata tctcatcgtc ttcatccatc tcatcatttc
    14821 atagttcttt ctgtaatcca attaagaaca aaaataagaa ataatactgt aaagttctct
    14881 aacttcagct atttattatt ctaaaaagaa ggaaagcagt cctctttcag accatcgaaa
    14941 agtattaaca aaagtataaa gcgtaaaaca aacacttaat caatgttata aaacatagcg
    15001 ttttacttgg ataatttgca gatttcacag aagtccgtat ctttgcactg tgtttttcat
    15061 agtattagat ttaaggttaa caaaggttgg agcaaggcgt tgctcctttt tttatgctct
    15121 gacctttcat ctaccggtta gttttcatcc cattcctttt ccagtttacc atcaatagtg
    15181 tagcgtttcc atcgtcctac acggtgacca ttcttatatt ccccacattc acgaagctgg
    15241 tcattcttta cataacgagc ttcgaacggt ccgttctgcc ttccgttcac ataggtagaa
    15301 gtttcccaat aatcaaagcg gttgctcact atcagccgtc gttccttgcc atgcaatctg
    15361 ccggcctgat aggtagcttc atatctcaat tcaccatttt ccaaattata ttcacggtat
    15421 aaaccgtctt tacgatcgtt cttcatataa tattctttct gccttacccc acttccgttg
    15481 gcaaatgaga catggagtcc atcttctttt ccatccagat aggtttcaat catcagcgta
    15541 tctccgcttt cagcaaaagt agtccaacga ccattcttct ttccattctt ataactaccc
    15601 agtatacgtg gcgagccaaa cgtaaacacg gacgaatatt caccgtcctg aaaaccttct
    15661 tcattgaaat aaacggtctc atacaaatca tatgtacctt tcagaaaagt atactgtttg
    15721 cctacctgct tcccgtcctt gtaattatgc tctttccgca aagtaccgtc agattcgtac
    15781 gacagttgct tcccgtgctc tttccccatc cggaagtttc tttcactttc cacttttccg
    15841 gtagtaaagt aacttttgct cgtaccgtcc agcttacctt ccttatagga cttttcttct
    15901 ttcagcttac cgtcaaactt ggagttaatc ttgaagaggc catccttccg cccttcttta
    15961 taacttcctt ccgttattaa tatattgtcc acatattctt tgtatccgcc atcataaaaa
    16021 ccatctttaa aagatgccag cacataggcg gaatgataac catctatgat gcgatgttcg
    16081 ccattcaatg ctttttccgt tttcagttcc tgaaacaaca gtctgccatc gcctacatta
    16141 acaacagata cctgatcgat cttatattcc ttttgcgcaa acaaaggaag agcaagatat
    16201 aaaaacaaaa atacgttcca gctttttgat ctgaggaagt tcgaaatgtg tttcataaag
    16261 tagttttctc tttttgattt attatttaaa aacctgccgc aaagataggc aatcggctta
    16321 taaaacaagg caagaaagag ggggacaatt agaaaaaaga acatctgtta ttatcattct
    16381 aataattaac agattaagta gtaaatcaaa acacagggaa gggggacatt tactgaaata
    16441 agaaacagaa aagaagatgt gtcaaaagca actaaattcc cctccttcag gaaggaggag
    16501 agtttagttg cttttgacac atttacattt gcagtattaa atatcacaac aaaatataag
    16561 tgtat
//
