LOCUS       c00036_gnlPro..        14587 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MLFNLBCE_36.
ACCESSION   c00036_gnlPro..
VERSION     c00036_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 18:02:29
            Original ID  :: gnl|Prokka|MLFNLBCE_36
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14587
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14587
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[519:4587]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      520..4587
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..14587
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14587
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             3..107
                     /locus_tag="ctg36_1"
                     /transl_table=11
                     /translation="THAIVAAAGVGEEDVPYIPGSIYSSGSTGRLLEV"
     CDS             complement(116..499)
                     /locus_tag="ctg36_2"
                     /transl_table=11
                     /translation="MDIEEFRKYCLSLGDVSEKMPFGKFAARYDSILAFYVYGHMFCFI
                     DIDNFTFVNVKSTSDEIEYIKERHVSVGNPINQSLKHWLQLNFDGDIPDTSIYTWVQRA
                     FEIVRDKYTKPTTHKKKCSKPKL"
     CDS             complement(520..1005)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_3"
                     /sec_met_domain="ECH_1 (E-value: 6.8e-55, bitscore: 176.5,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVNGYAIGGGHVLHVVCDLTIASENAIFGQTGPKVGSFDAGFGSS
                     YLARIVGQKKAREIWFLCRQYSAQEALEMGLVNTVVPFDRLEDETVAWAEKMMEHSPLA
                     LRMIKAGLNAELDGQAGIQELAGDATMLYYMTEEAQEGGKAFLEKRKPRFQDYPKFP"
     CDS             1096..1368
                     /locus_tag="ctg36_4"
                     /transl_table=11
                     /translation="MTFYVHISPAAEGFVTCSGQNHYIDILALAAVIQGVADFRSSGGG
                     ERIAVTRTVDGDFRYSVVKVKQNILIFFDGFPFSCFHYSFLFLSP"
     CDS             complement(1341..1787)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_5"
                     /sec_met_domain="TPP_enzyme_C (E-value: 9.7e-08, bitscore:
                     22.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VNGIEGSLSTAIGYAAASSKLNFIIIGDLSFFYDMNALWNQNYGA
                     NIRILLLNNEGGEIFHTLPGMDKSSRSREFITAEHYTTAKGWAEERGFIYMKVTGEEEL
                     EEAMQPFTSPETRMQPMLLEVFTDKEKDTTLLREYYHGLKNKNE"
     CDS             complement(1784..1933)
                     /locus_tag="ctg36_6"
                     /transl_table=11
                     /translation="LLIPKSPLSENSFRHYPNPVPCIWQTAPPCAMHSYLQFLPGWKSV
                     ATGA"
     CDS             2121..2639
                     /locus_tag="ctg36_7"
                     /transl_table=11
                     /translation="MIAQVFLQLLGYDMSAVGNQYFGGHVFLALRRHGINGGVEILDRN
                     AGDGLVAQMFRQPGEMFIKRFHIFFLEQVNQIHLAYHDHALVVLVQPFDQFLIVTVVHA
                     QSLITGDDTCLGKCFGGEAVDGFGNGYIDMYGSFAVVGGFQYGFVDEAVAKPFVFLCMY
                     FGQVDRHLD"
     CDS             complement(3014..4183)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg36_8"
                     /sec_met_domain="Chorismate_bind (E-value: 3.4e-57,
                     bitscore: 184.4, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLPDIHTQKLLDCLTHSRLGFALYRLPWTDECYLVLQTSGDVEQ
                     LADIQELNEKKGFVMAPFRISEEHPLVLIRPDVTAYDWNEISEALSSLECVDTLLTCKS
                     RQNELSPFVSEETDKEQYTRAFGRFITPLQEKQFQKLVLSRSSARHIGDDFSPLGAFVR
                     ACNNYPRMMIYLCHTPASGTWLGSTPEILLSGQGKEWHTVALAGTMPMQDEVMPTNWDK
                     KNQEEQGYVADYIRRIAKKFGNKMTEKGPYTARAGQLVHLKTDFYFLLKNTDHIGDLLQ
                     ELHPTPAVCGLPKEEAFRFILNNEGYDRSYYSGFTGWLDTEGHTDIYVNLRCMEIKPGE
                     AILYAGGGILASSEVESEWVETGDKMNTMRSILHPDFISKQMETIKVEE"
     CDS             complement(4180..4587)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_9"
                     /sec_met_domain="HBT (E-value: 1.7e-14, bitscore: 44.6,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMEEITCKPDYSNSMAEHLGIRFLPPTENAVHAEMPVDHRTSQPF
                     GMLNGGASLALAEIVAGHGSMSLCREGEYACGVQVSGNHLSAVPVGGKVFATGKLIHRG
                     RSSHIWNIDITTPQGELVSTVRVVNFILKKK"
     CDS             complement(5043..5402)
                     /locus_tag="ctg36_10"
                     /transl_table=11
                     /translation="MNIVVSVFPPFRKKPFTERKQHQSTHCHTNNPYRKKREERKRRKT
                     SRSQRILNNKVGRRTNQCHHTSHTAGKRQRHKQTTGIHVGTDCQTDHDRQHQSHRTCVA
                     HKSPDSRSHQHYKQE"
     CDS             complement(5568..5717)
                     /locus_tag="ctg36_11"
                     /transl_table=11
                     /translation="MLVQHLQQIIFGKQLYFLKIPRHIQNILFLKNRTGIGQLLSNCFQ
                     EAVL"
     CDS             complement(5748..6419)
                     /locus_tag="ctg36_12"
                     /transl_table=11
                     /translation="LHRDRSQKHCGSRVADKHRHQGSSEINTRHQRQRSVCSQFTDQTV
                     RNVFGSPCLFQCQRHRQHGRNEYDAFPVNGFVSRLHIAETSCQYHQDTRNHHRRHRSYR
                     NEVEHHHCHHQHHDNRSYRCFVIQRDLRSLGQRLSQYHPVGIFLAQPGDIVPCTLHQQH
                     IPAMNPLIAQVLQQIFLLPADTQYIHIKFITKARPLYRLVYQIGGRHQNDFSNTYVIKI
                     Q"
     CDS             complement(6601..7890)
                     /locus_tag="ctg36_13"
                     /transl_table=11
                     /translation="MIIGSLLQQCYNIADTLIVGQCIGSGALAAVGSAYTLMVFLISIL
                     LGLSMGSGTVFSLQYGAGRTDSLRRNIYVSALLIGTVTLILNIAAFVWIHPILRLLQIP
                     KDIYGMMYDYLWIIFWGIGFTFIYNFYAALLRAIGDAVTPLWFLAVSVVLNIGLDLFFI
                     LQLDWGIKGAAIATVAAQGVSALGIMGYAYVKYPELRLHRNDLHFDRHCLKEITSFSAL
                     TCVQQSVMNLGILMVQGLVNSFGTVVMAAFAAAIKIDSFAYMPVQEFGNAFSTFIAQNF
                     GARKEERIRKGVKSALITTVLFSLVISILVFLFAKPLMLIFVRPHETEILNIGISYLRI
                     EGAFYCGIGILFLLYGYYRAIRMPGMSVVLTVVSLGTRVALSYWLAGIPAIGVIGIWWS
                     IPIGWFIADVIGIIYYKQLKKETAKEVPAP"
     CDS             8193..10694
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_dim"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg36_14"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2.5e-62, bitscore:
                     201.2, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="Pyr_redox_dim (E-value: 1.2e-14, bitscore:
                     45.1, seeds: 83, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYIVIGGVAGGATAAARIRRNTEQAEIILFEKGEYISYANCGLP
                     YYIGGVIAEREKLFVQTPEAFGKRFNIDVRTRSEVIAIHSAEKTVDIRTSDGKTYTESY
                     DKLLLSPGASPVRPPLPGIDNEGIFTLRNVNDTDAIKSYLQQHKVKRAVIIGAGFIGLE
                     MAENLQEAGAEVAVVEMANQVMAPIDFSMASLVHEHLLQKGVHLYLEKAVASFERTVNG
                     LEVVFKSGERLPADMVLLSIGVRPNTSLAIEAGLEIGEMRGIKVNDYLQTSNEHIYAVG
                     DAIEFRHPLTDRPWLNYLAGPANRQARIVADNMVFGNKVTYEGAVGTSIAKVFDMTVAA
                     SGLPAKRLKQAGIDYLSATIHSGSHAGYYPDALQMSIKITFSPVNGKLLGAQIVGYNGV
                     DKRIDEFSQVIKHNGTVYDLMALEQAYAPPFSSAKDPVAVAGYVAGNILSGKMKPLYWR
                     ELQAADLSKVTLVDVRTPDEFALGALKGAVNIPLDDMRERMKEIPQDKPVYLYCGVGLR
                     GYLASNILLQNGFGEVRNLIGGLKLYKAATAPLPEPEEFSNSGSSSSDSSKVDHSEHSK
                     DSAGAYTIASSVIPSMKAIKVDACGISCPGPIMKLKKSMEELADGERLEIVATDAGFPR
                     DAEAWCHTTGNRFVSVKSGAGKYEVIVEKNTPQSSSSEVCREDKGKTFILFSDDLDKVL
                     ATFVLANGAAATGKKVTIFFTFWGLNAIKKLDKPVVKKDIWGKMFGMMLPSSSLKLKLS
                     KMNMGGMGARMMRYIMNKKNIDSLESLRTQAIQNGVEFIACQMSMDVMGVKREELLDHV
                     TIGGVATYMNRAEQANVNLFI"
     CDS             10701..11057
                     /locus_tag="ctg36_15"
                     /transl_table=11
                     /translation="MEKIKSICVMRELFKALSELETRLIEQYGVSLNEAMALCCIGGDT
                     LTASVISENTGLSASHTSKVIRSIEEKELIVRNLGDKDKRQMHFTLSDKGHECLEALKA
                     NEIEIPELLKPLFK"
     CDS             11090..12688
                     /locus_tag="ctg36_16"
                     /transl_table=11
                     /translation="MKLEKWKNKWKKWSNLRKWQIWKLKLIDARLYFVSIFVGLLTGLV
                     AVPYHYLLWYFFDVRKTFFTAHYPWYWHVLLFFILWGILIFVASLVKRMPLIAGGGIPQ
                     TRAANNGRIRYEHPFKELVAKFCGGVLALSAGLSLGREGPSVQIGSYIGTLISRWGHIL
                     KGERKQLLAAGAGAGLSAAFAAPLSSSLLVIESIERFDAPKTAITTLLAGVVAGGVASW
                     MFPTTPYHLISAVVPGLSFIRQAELYIIFAALMAVIAKFYSLIVPFFQERIPAMKLSIP
                     VKMLYLLTIAYAISLTETNLTGGGEQFLMMQGMNGTHDIRWLTIMMLIHFVFTLFSLSS
                     GLPGGSFIPTLVTGGLLGQIFGLVLVQRGWIGYENVSYMMLIGMVAFLVAVVRTPLTAI
                     VLITEITGHFEVFYPSIVVGGLTYYFTELLQIKPYNVLLYDRMFRSHNPESSEEAGARY
                     HLFVEIMDGSYFDGKEVDTLALPNHCIIRSIHRNRKNLLPQGQTLVPGDQVEIEIDAQD
                     IEKLYEPLVSMANIY"
ORIGIN
        1 tcacccacgc catagtggcg gctgccggtg tcggtgagga ggatgtacca tacatcccgg
       61 gtagtatata ctcctctgga agtaccggca ggttgcttga agtgtaattg tttttttata
      121 atttgggttt ggaacatttt tttttatgtg tagttggttt ggtatattta tccctgacaa
      181 tctcaaaggc gcgttggacc catgtgtata tgctcgtgtc gggaatatca ccatcaaaat
      241 taagttgaag ccaatgtttc agactttggt tgatgggatt gccgactgaa acatgtctct
      301 cttttatata ctcaatttcg tccgaagtag atttgacatt gacaaaagtg aaattgtcaa
      361 tgtctataaa acagaacatg tgtccataaa cataaaaggc aaggatggaa tcatatcttg
      421 cagcaaattt gccaaatggc atcttttcgg aaacgtcacc taacgaaaga caatattttc
      481 tgaattcttc aatgtccatg ctttgaattt gtagtttgtt tatgggaact tcggataatc
      541 ctggaaccgt ggcttgcgtt tttccaaaaa tgccttccct ccttcctgcg cttcctctgt
      601 catgtaatac agcatggtgg catctccggc aagttcttgt atgccggctt gtccgtccag
      661 ttcggcattc agtccggctt tgatcatacg aagagcgagc gggctgtgct ccatcatctt
      721 ttctgcccat gccacggttt cgtcttccag gcggtcgaaa ggaacgactg tattgactaa
      781 tcccatttcc agtgcttcct gtgcggagta ttgacggcaa aggaaccata tttcacgggc
      841 tttcttctgc cctacgatgc gtgccagata ggaagagccg aatccggcgt cgaagctgcc
      901 taccttggga cctgtctgtc cgaaaatggc attttctgag gcaatggtca gatcgcatac
      961 cacatgcagc acatggccgc cgccgatggc gtaaccgttt accatggcga tgaccggttt
     1021 tggcagtgac cggatttgct tttgtacgtc cagcacattc agacggggaa ctccatctgt
     1081 gccgatataa ccgccatgac cttttacgtg catatctccc ccgctgcaga aggctttgtc
     1141 acctgctccg gtcagaacca ctacattgat atcctggcac tcgcggcagt aatacagggc
     1201 gtcgctgatt tccgaagtag tggtgggggt gaacgcattg cggtaacgcg gacggttgat
     1261 ggtgattttc gctattccgt tgtaaaagtc aaacagaata tcttgatatt ctttgatggt
     1321 tttccatttt cttgtttcca ttattcattt ttatttttaa gtccgtgata atattctctt
     1381 aatagggtgg tgtctttttc cttgtcggta aacacctcca gcagcatggg ttgcatcctt
     1441 gtctcgggtg aggtgaatgg ctgcatcgct tcttccagct cttcttctcc ggtcactttc
     1501 atgtaaataa agccacgttc ttccgcccag cctttggcgg tggtgtaatg ctcggctgtg
     1561 ataaactccc gggaacggct tgatttatcc attccaggca gggtatggaa tatttctcct
     1621 ccttcgttat tcagtaacag gatgcggatg ttggcaccgt aattttgatt ccacagtgcg
     1681 ttcatatcat agaagaagct caagtcgcct atgatgatga aattcagctt gctggaagcg
     1741 gcggcataac cgatggcggt ggacagggag ccttctatgc cgttcacgcc ccggttgcaa
     1801 cagatttcca cccggggagg aactgtaaat aactgtgcat agcgcacggt ggagctgttt
     1861 gccagatgca gggcacaggg ttcgggtaat gcctgaatga gttttccgat aacggagatt
     1921 tcggaataag caagatccgg catcggaatg gttttgcaat agttttccca catcagcgga
     1981 taatgggtcg gtttgttgtc cagcaggaaa gctatttttt ccaagaactc aaacggatcc
     2041 atctcgatga cggtggtcag gcaaccgtat aaatcggcta tcttcccgtc ggcggcaaca
     2101 tgccaatgtt cgcgcggggg atgattgcgc aggtatttct tcaattgctt ggatacgata
     2161 tgtccgccgt aggtaatcag tatttcgggg gccatgtctt cctggcgctc cggcgtcatg
     2221 gaataaacgg cggcgtcgaa attcttgata ggaatgccgg ggatggtctg gttgcccaga
     2281 tgttccgtca accaggcgaa atgtttataa agcggtttca catatttttt ctcgaacagg
     2341 taaatcagat tcatctggcc taccacgacc atgcgcttgt tgtacttgtt cagccgttcg
     2401 atcagttcct tatagtcacg gtcgtacacg ctcagtccct gataacgggt gatgacacgt
     2461 gcctcgggaa gtgttttggc ggtgaagcgg tagatgggtt cggaaatggg tacattgata
     2521 tgtacgggtc ctttgccgtg gtgggtggtt tccagtatgg cttcgttgat gaggcggttg
     2581 caaaaccatt cgtcttcctc tgtatgtact tcgggcaggt tgacagacat cttgactaac
     2641 gttccgaaca catggggctg gggcagggtt tgtccgtcca tttgtcctat ccaggcggcg
     2701 gggcggtcgg cagaaatgac aatcagaggt acttgttggt aaaaagcttc ggctactgca
     2761 gggtgcaggt tcagcagggc cgaaccggag gtgcagcata ctgcggcagg acctccccct
     2821 tgtaaagata ggccgatagc aaaaaaaccg gcactgcgtt catcggttac agaataacaa
     2881 gtgaagtcct ctatattggc cagagtgtgt acgatggcag cattacggct gccgggacaa
     2941 agcactattt tccgcacacc gtgcgctttg agaagtgcca ccaactgaag tatgttcttt
     3001 ttgtctgaat acattattct tctactttaa ttgtttccat ttgtttactt ataaagtcag
     3061 gatgaaggat gctccgcatc gtattcatct tgtctcccgt ttccacccat tccgattcta
     3121 cttccgagga agccagtatt cctcctcctg catacaggat ggcttcaccc ggctttattt
     3181 ccatgcagcg cagattgacg tagatatcgg tatgtccctc tgtgtccagc catccggtga
     3241 atccggaata ataactgcgg tcgtaccctt cgttgttcag aataaaccgg aaagcctcct
     3301 ctttgggcag gccgcagacg gcgggagtgg gatggagttc ttgcaataaa tcgcctatat
     3361 ggtctgtatt tttcaacaag aaataaaaat cagtcttgag gtgtaccaat tgtccggcac
     3421 gggcggtata gggacctttc tccgtcatct tgttgccgaa ttttttggcg atccggcgga
     3481 tataatcagc cacatagccc tgttcttctt ggttcttctt gtcccagttt gtcggcatca
     3541 cttcgtcctg catcggcatt gtaccagcca gggccacggt gtgccattct ttgccttgtc
     3601 cgcttaataa gatttccggt gtgctgccca gccaggttcc ggaagcgggg gtgtggcata
     3661 ggtaaatcat catgcgcgga taattgttac aggcccggac aaaagcgcca agtggtgaaa
     3721 aatcatctcc gatatgtctg gcggaagaac gtgacagaac caatttctga aactgcttct
     3781 cttgtaaggg agtgatgaaa cgcccgaatg cgcgggtata ttgttcttta tccgtttctt
     3841 cggaaacaaa aggagagagt tcattctgcc ggcttttgca ggtgagcagg gtatccacac
     3901 attccagtga agacagtgct tcgctgattt cattccagtc gtatgccgtg acatccggac
     3961 ggataagtac caagggatgt tcctccgata tccggaaagg agccatgaca aatccctttt
     4021 tttcattcag ttcttgaatg tccgctaatt gttccacatc gcccgaggtt tgcaatacca
     4081 ggtagcattc gtctgtccaa ggtaaccggt agagggcgaa accgaggcgg ctatgtgtca
     4141 ggcaatccaa taatttttgc gtatgtatat ctggtagatt catttctttt tcagtatgaa
     4201 attaacgaca cgaacagtag aaaccagttc tccctgtgga gtggtgatat ctatattcca
     4261 tatatgcgag gatctgccgc ggtgaatcag tttgccggtg gcgaatactt tgcctccgac
     4321 gggtacggcc gacagatgat ttccacttac ttgtactccg caggcatatt cgccttcccg
     4381 gcatagcgac atggagccat gtcctgccac aatctcggcc agagccagtg acgcgccgcc
     4441 gttcaacata ccaaagggtt gtgaagtacg atggtctaca ggcatttcgg catgtaccgc
     4501 attctcggtg gggggtagaa accggatacc cagatgttcc gccatcgaat tcgaataatc
     4561 aggtttgcag gttatttctt ccatcatttg tatgtctgtt cttttctata gggctacaaa
     4621 aatacataaa ttttagatga aaatgtcgct aatgttgttc ttttaagaac aaaaacattc
     4681 ggggtttgtt tctattttcg gaatatattt tttattttgc aaaaagaatt cgtacaaatg
     4741 caacaacgaa tgaataaaac aataatttaa tacctatgct cattacgatt attatccttg
     4801 tactgtccgc agtatttttt gtaaatggca agatacggtc ggatcttgtg gctctttgtg
     4861 ctttagtggc tttgttgatt tttcagatat tgacgcctga cgaggctttg tccggattct
     4921 ccaattcggt cgtcattatg atggtggggc tgtttgtggt tggcggagcg atttttcaga
     4981 cgggacttgc caaaatgatc agttcacaca ttctgaaatt agcgggtaag agtgaattga
     5041 aattattctt gcttgtaatg ttggtgactt ctgctatcgg ggcttttgtg agcaacacag
     5101 gtacggtggc tctgatgttg cctatcgtgg tcagtctggc agtcagtgcc aacatgaatc
     5161 ccagtcgttt gcttatgccg ttggcgtttg ccagcagtat gggaggtatg atgacactga
     5221 ttggtacgcc gcccaacctt gttattcaaa atgcgttgac ttcggctggt tttcctccgc
     5281 tttcgttctt ctcttttttt ccggtaggga ttatttgtgt ggcagtgggt actttggtgt
     5341 tgcttccgct cagtaaatgg tttctttcga aacgggggaa aaacggagac aacaatgttc
     5401 attcgggcaa atccctgaaa cagttggtga aggaatatgg gctatccagt aatttgttcc
     5461 ggttgagggt ggtcggtgac tcccggctgc atggaaagac gattatagag ttggatatcc
     5521 ggcgcaagta tggattgaat atactggagg tgcgtcgtgg ggatatgtca caacaccgct
     5581 tcctgaaaac aattactcag aagctggccg atcccggtac ggttcttcag aaagaggata
     5641 ttctgtatgt gacgggggat tttgagaaaa taaagttgtt tgccgaagat tatttgctgg
     5701 agatgctgga cgagcatact accgaagaag cgaaaaactc agccaattca ttggattttt
     5761 atgacatagg tattgctgaa atcgttttga tgccttcctc caatttgata aaccagacga
     5821 taaagggggc gggctttcgt gataaattta atgtgaatgt actgggtatc cgccggaaga
     5881 aggaatattt gttgcaggac ttgggcaatg agcggattca tagcggggat gtgttgctgg
     5941 tgcagggtac atggaacaat atcgcccggc tgagcaagga agatgccgac tgggtggtac
     6001 tgggacaacc gctggccgag gctgcgaagg tcacgctgga ttacaaagca ccggtagctg
     6061 cggttatcat ggtgctgatg gtggcaatga tggtgttcga cttcattccg gtagctccgg
     6121 tgacggcggt gatgattgcg ggtatcctga tggtactgac aggatgtttc cgcaatgtgg
     6181 aggcggctta caaaaccatt aactgggaaa gcatcgtact cattgcggcc atgctgccta
     6241 tgtcgctggc attggaaaag acaggggctt ccgaatacat ttcgaacagt ctggtcagtg
     6301 aactgggaac atacggaccg ttggcgctga tggcgggtat ttatttcact acttccctga
     6361 tgacgatgtt tatcagcaac acggctaccg cagtgcttct ggctcctatc gcgatgcaaa
     6421 gtgcaacaca gataggggta agtcccgtac cttttctctt tgcggtgaca ctgggggcaa
     6481 gtatgtgttt cgcttctcca ttctccactc cgcccaatgc gctggtgatg cccgccggac
     6541 aatatacctt tatggattat gtaaaggtag ggctgccgtt gcagattatt atgggcattg
     6601 tcatggtgct ggtacttcct ttgctgtttc ctttttaagt tgtttataat atatgatgcc
     6661 gatgacgtcc gctataaacc atccgatagg aatagaccac cagattccga tgaccccgat
     6721 ggcaggaatg ccggcaagcc aataggaaag ggctacacgg gttcccaacg ataccactgt
     6781 gagcactacg gacattcccg gcatacggat ggcccgataa tatccgtata acaggaacaa
     6841 aatcccgatt ccgcaataaa acgctccctc gatgcgtaaa taactgatac cgatgttcag
     6901 aatttccgtt tcgtgggggc ggacaaaaat cagcatcaat ggtttggcga ataaaaagac
     6961 cagaatggaa atgaccagag agaagagaac ggtggtaatc aaggcacttt tcactccttt
     7021 gcggatccgt tcctcttttc tcgctccgaa gttctgggca ataaaggtgg aaaaggcatt
     7081 tccgaattcc tgtaccggca tataggcaaa cgagtctatt tttattgctg ccgcaaaggc
     7141 ggccatgact acagtgccaa aactattgac caatccttgt accatcagaa tgcccagatt
     7201 catcaccgac tgttgtacac aggtcagtgc ggagaacgaa gtgatctctt tcaggcagtg
     7261 acggtcgaaa tgcaggtcgt tgcggtgtaa tctcagttcg gggtatttca cgtaggcata
     7321 tcccataatt cccaaagcgg atactccctg tgcggccacc gtggcgatgg ctgctccttt
     7381 gattccccaa tccaactgca agataaagaa taaatccagc ccgatgttca gtacaacgga
     7441 aaccgccaga aaccaaagag gagtaacggc atctcctatg gcacgcagta atgccgcata
     7501 gaaattatag ataaaggtaa agccgattcc ccaaaagata atccacaagt aatcatacat
     7561 catgccataa atatctttgg gaatctgcaa taacctgaga atgggatgaa tccagacgaa
     7621 agccgctata tttagaatca atgttactgt accgatcagc agggcggata catagatgtt
     7681 acggcgtagg gaatccgttc gtccggctcc atattgcaag gaaaaaacgg ttccgcttcc
     7741 catggacaat cccagcagga tggaaatgag gaaaaccatc agcgtatagg cggaaccgac
     7801 ggcagccaat gcgccggaac ctatacattg tcctacaatc agcgtgtcgg ctatattgta
     7861 acactgttgt agcagtgagc ctataatcat aggtaaggta aaacgtagca gagtgccggt
     7921 gatacctccc tgcgtcaagt ctattttaga taacatgatg cgtgtctgtt cgattcaatt
     7981 tcttatttat tttgaaattt attgcgaagg tagggaataa aatatcaaac aacaataaag
     8041 attgtctatt taatacccgg aatgttcttt ctccttaaaa agagttaact tgataatatt
     8101 ttccatagga aactttttat tataagaaat atcatgtatg tttgcataaa gtttccattg
     8161 gaaaatatta aatcaaataa aatagtttaa tcatgaagta tatagtaata ggaggcgtag
     8221 caggaggtgc aactgctgcc gcacgtatca gaagaaacac ggaacaggcg gaaatcattt
     8281 tgttcgagaa gggagaatac atttcgtatg ccaattgtgg tctaccttat tatataggag
     8341 gtgtgattgc ggagcgggaa aaattgtttg tacagactcc ggaggctttc gggaaacgtt
     8401 ttaacataga tgtgcgtacc cggtccgagg taatagccat ccattctgcc gagaaaacag
     8461 tggatattcg tacttccgac gggaaaactt atacggagag ttatgacaaa ttattgcttt
     8521 ctccgggtgc gtcgcctgtt cgtcctccct tgccgggcat tgacaatgaa gggattttta
     8581 ccctacgtaa tgtgaatgat accgatgcta tcaagagtta cttgcagcag cataaggtga
     8641 aacgggcggt aatcatcggg gccggattca tcgggttgga gatggcggag aatctgcagg
     8701 aagccggtgc ggaagtggcg gttgtagaga tggcaaatca ggtcatggct cctattgatt
     8761 tctctatggc ttctttggtg cacgagcact tgttgcagaa aggagtacat ctctatctgg
     8821 aaaaggcggt ggcttctttc gaacgcacgg tcaacggact ggaggttgtt ttcaaatcgg
     8881 gcgaaaggct gcctgccgat atggtgttgt tatccatcgg ggtacgtccc aatacctcat
     8941 tggcgataga ggctggactg gagatagggg agatgcgcgg tattaaggtt aatgattact
     9001 tgcagacttc caacgagcat atttatgcgg tgggcgatgc tatcgagttc cgtcatccac
     9061 tgactgatag accgtggttg aattatctgg caggtccggc caaccgtcag gcgcgtattg
     9121 tggcagataa catggtcttt ggaaataagg ttacatacga aggggctgtc ggtacttcca
     9181 ttgccaaagt ttttgatatg actgtcgctg cttcgggcct tccggcaaaa cggttgaaac
     9241 aggcaggcat tgattatttg tcggcaacca tccattccgg ttcccatgcg ggatattatc
     9301 ctgatgcttt acagatgtcc attaaaataa ctttctctcc tgtgaatggg aaattactgg
     9361 gagcacagat tgtggggtat aacggagtgg acaaacgtat tgatgaattt tcgcaagtga
     9421 ttaagcataa cggaactgtt tatgacttga tggctttgga gcaggcatat gctcctcctt
     9481 tctcttcggc taaagatcct gtagcagtag ccggatatgt agctggaaat atactgagcg
     9541 gaaagatgaa gcctctttat tggcgcgagt tgcaggctgc cgatttgagt aaagttacgt
     9601 tggttgatgt tcgtactccc gatgaatttg cactcggtgc tttgaaaggg gctgtcaata
     9661 ttcctttgga tgatatgcgc gaaaggatga aagagattcc tcaggataag ccggtctatt
     9721 tgtattgtgg agtagggttg agagggtatt tggcttctaa tatattgtta cagaatggtt
     9781 ttggggaagt aaggaatttg ataggaggtt taaaactgta taaagcggca acggctcctc
     9841 tgcccgagcc ggaggagttt tcaaattccg gttcttcaag ttctgattct tcaaaagttg
     9901 atcattctga acacagtaaa gattctgctg gagcttatac tattgcctct tccgtcattc
     9961 cttctatgaa agcaataaaa gtggatgctt gtggcatatc ttgtcccggt cctatcatga
    10021 aactgaagaa gagtatggaa gaactggcgg acggcgaacg tttggaaatt gtcgctacag
    10081 atgccggctt cccccgcgat gccgaagcat ggtgtcatac taccgggaac cgttttgtct
    10141 cagtaaaatc aggagcagga aagtatgagg taattgttga gaaaaatact ccgcaatctt
    10201 cttcctcgga ggtttgccgg gaggataaag ggaaaacttt tattctgttc agtgatgacc
    10261 tggacaaagt tttagctact tttgtactcg caaacggtgc ggcggctacg ggaaagaagg
    10321 taaccatctt ctttactttc tgggggctga atgccatcaa gaagctggac aaacctgtgg
    10381 tgaagaaaga tatctggggg aagatgttcg gcatgatgct gccttccagt tctttaaagt
    10441 tgaagttgtc taaaatgaat atgggcggaa tgggagctag gatgatgcga tatattatga
    10501 ataagaaaaa tatcgattca ttggaatctc tgcgtactca agccattcag aacggagtgg
    10561 aatttattgc ttgccagatg tcaatggacg taatgggtgt gaaacgtgag gaattgctgg
    10621 atcatgtgac tattggtgga gtggcaactt atatgaaccg tgccgaacag gcgaatgtaa
    10681 acttgtttat ttaaatttgc atggagaaaa taaaatcaat atgtgtcatg agagagctgt
    10741 tcaaggctct ctctgaactt gaaacccgct taattgaaca atatggagtg tcattgaatg
    10801 aggcaatggc actttgttgc attggcggag atacgctgac ggctagtgtg atatcggaaa
    10861 acacaggtct gtctgcttcg catacctcta aggtcatccg ttccattgaa gagaaagaat
    10921 taatcgtccg taatttgggg gataaggata aacggcagat gcattttact ttatccgata
    10981 aagggcatga atgtttggaa gcgctgaaag caaatgaaat agaaataccg gaactattaa
    11041 agccattgtt taaataaacc cttctctttt ccatttgttt attccggata tgaaactgga
    11101 gaaatggaaa aacaaatgga agaagtggag caatctgcgc aaatggcaaa tatggaaact
    11161 gaagctgatt gatgcccgtc tgtatttcgt gagcatattc gtggggctgc ttacgggact
    11221 ggttgctgtg ccttatcact atcttctttg gtatttcttt gatgtgcgga aaactttttt
    11281 tacggcacat tatccgtggt attggcatgt attgttgttt tttatcttat gggggattct
    11341 gatctttgtc gcttctttgg taaaacgtat gccattgata gccggtggtg ggattcctca
    11401 gacacgtgcg gccaataacg gtcgtatccg ttatgagcat ccttttaaag aactggtagc
    11461 taaattctgc ggaggggtgt tggctctcag tgcggggctg tctttgggac gcgaggggcc
    11521 gtctgttcag atagggtctt atataggaac acttatctct cgttggggac atattctgaa
    11581 aggggaacgg aaacaattgc tggctgccgg agctggtgcg ggcttgtctg ccgcttttgc
    11641 tgctccgttg tcttcttctt tgttggtgat agaatccatc gagcgttttg atgcacctaa
    11701 aaccgctatt actaccttgt tggccggcgt ggtagccgga ggagtggcta gttggatgtt
    11761 ccccacgact ccttatcatc tgattagtgc ggtcgttcct ggtttatctt ttatccgtca
    11821 ggcggagctt tatattatct ttgccgccct tatggctgtc attgcaaagt tttattcgct
    11881 catcgttcct ttctttcaag aaaggatacc tgccatgaaa ctctccattc ctgtcaagat
    11941 gttgtattta ttaaccatag cttatgccat atcgttaaca gagacgaatc tgacaggtgg
    12001 cggagagcag tttttgatga tgcagggaat gaatggaact catgatatcc ggtggcttac
    12061 tatcatgatg cttattcatt ttgtttttac gctgttttct ctttcttcgg gtttgccggg
    12121 aggaagtttc attcctacct tggttacggg aggattattg ggacaaatct tcgggttggt
    12181 attggtacag cgcggatgga tagggtatga gaatgtgagt tatatgatgc tgatcgggat
    12241 ggtggctttt ttggtggctg tggtgcgtac tcctttgact gctattgtcc tgataacgga
    12301 gattaccggt catttcgagg tgttctatcc ttccattgtg gtaggtggat tgacttatta
    12361 tttcaccgaa ttgttacaga taaaacctta caatgtattg ctgtatgaca ggatgttccg
    12421 tagccataat ccggagtctt ccgaagaggc tggtgctcgc tatcatcttt ttgtcgagat
    12481 aatggatggg tcttattttg acggaaagga agtggataca ttggctttac ctaatcattg
    12541 tatcattcgt agtatacatc ggaatcgtaa aaacttactt cctcaggggc aaaccctggt
    12601 tcccggtgat caagtggaga tagaaataga tgcgcaggat atagaaaaat tatacgaacc
    12661 gttggtcagt atggcaaata tctattaaaa gatgagtcta aaaaagcccc cgttaaagga
    12721 cgagggcaac ctaaatgttt tcacaacgga ataatcctta ttgtgacttg cttcaaatta
    12781 gtattgcaaa actatgaaat aaatatgtaa agaacaagtg attattagaa taatttgata
    12841 actttgaaaa gttttgataa aatagttgtc ttatgaaaaa tatagtgggt cttgatttgg
    12901 gtaccaatag cataggttgg gcagtagtaa atggaagtgt caatgacgat ggaagtgaac
    12961 aattggttaa gatacaagct tctggaagtc gcatcatacc tatggatgca gctatgatag
    13021 gagattttaa taaaggtaat tccatatctc aaactgctga aagaaccaga ttgcgtggag
    13081 ttcgtcgttt aagcgaacga tatctgcttc gcagagaacg gttgcataga attcttgata
    13141 ttttaggatt tttgcctttt cattttgctc aagatttaga taggcatggt aagatagtta
    13201 agggcaagga acctaaattg gcttggcgta agaatgaagc tggtcagttt gaatttatat
    13261 tccaagattc atttaaggaa atgctggagg attttaagct aaatcatccg aatctgataa
    13321 cagatgataa aaaagtacct tatgattgga ctatctacta tctccgtaaa aagggattga
    13381 cttctaaaat ttcaaaagaa gaattggcgt ggatattatt gaattttaat caaaagcgtg
    13441 gatattatca attacgtggt gaggaagagg aggaaaataa gaataaattg gttgaattct
    13501 atgctcttaa agtggttgca gtagaggatt ccggagaaaa aaagggaaag gatatttggt
    13561 ataatgtgca tttggaaaat ggatgggtat atcgaagaac aagtaatatg cctcttgatt
    13621 gggttggaaa aactaaagag ttcattgtaa ctacggattt agagaaggac ggaactccga
    13681 aaaaagataa ggaagggaat gtaaaacgct cttttcgtgc tcctaaggaa gatgattggt
    13741 cattggtcaa gaagaaaaca gaagcggata ttgatcaaac tcataagaca gtaggtgcct
    13801 atatttatga tacgctttta ggaaatccta gtcagaaaat tcgtggaaga ctggtgagaa
    13861 ccattgaacg caaatattat aaggaggagc tgaaacagat tttggagaag cagaaggagt
    13921 ttcacctgga attgcaagac agagcattgt atgctgcttg tgttgaagaa ctatatacaa
    13981 taaatgaagc acatcggaat aatattggta atcgggattt tacttatttg tttttagagg
    14041 atatactctt ttatcagcgt cctcttaaaa gcaaaaaatc attaatagac aattgccctt
    14101 atgaggagaa tcattgcctt gataaggaaa caggagagat aaaatctttt cctgtaaaat
    14161 gtattgctaa atcacatccg ttatttcaag aatttcgttt gtggcaattt atagtaaatc
    14221 tgcgtattta taggaaagac ctggcacaag atgtggatgt tacaaatgag ttattgaaga
    14281 ctgaagaaga ttatgttgct ttatttgact ggttgaatgg taaaaaagaa attgatcaaa
    14341 aggctttttt gaaatatccg ctttttggac tgaaaaaaga ggtagagaat tatcgttgga
    14401 attatgtaca agataaacct tatccatgta atgaaacccg ttcatcgatg ttggcgcggc
    14461 tggagaaatg tgatatttct attgaattcc tgacaaaaga gaatgaggaa gctttatggc
    14521 atatattata ttcggttgaa gataagaatg aaatagtaaa agctttgcag aaatttgcgg
    14581 ataaaca
//
