LOCUS       c00505_gnlPro..        15990 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|INHBHKAO_505.
ACCESSION   c00505_gnlPro..
VERSION     c00505_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 18:23:44
            Original ID  :: gnl|Prokka|INHBHKAO_505
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15990
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15990
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[190:5990]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      191..5990
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..15990
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15990
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             191..1813
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg505_1"
                     /sec_met_domain="ILVD_EDD (E-value: 1.7e-205, bitscore:
                     674.3, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VKAEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADSV
                     EYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLIDA
                     MIKSADDSVSDQEVANIEQNACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATHE
                     NRTKLFEDAAKLIVENAMKYYEEGDESVLPRSIATRQAFLNAMTLDIAMGGSTNTVLHL
                     LAVAHEAGVDFKMDDIDMLSRKTPCLCKVAPNTQKYHIQDVNRAGGIIAILAELAKGGL
                     IDTSVLRVDGMSLAEAIDQYSITSPNVTEKAMSKYSSAAGNRFNLVLGSQGAYYQELDK
                     DRANGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQEAA
                     CEGILGGRVVSDDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGGT
                     SGLSIGHVSPEAAAGGNIGKIVDGDIIEIDIPARTINVRLTDEELAARPMTPVTRDRYV
                     PKSLKAYASMVSSADKGAVRLID"
     CDS             2083..3558
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg505_2"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.1e-46, bitscore:
                     149.3, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LVTSGPGATNTITGIADAMIDSTPIVVIAGQVGTGFLGTDAFQEV
                     DLVGITQPIAKWSYQIRRAEDVAWAIARAFYIASSGRPGPVVLDFAKNAQVEKTKYEPT
                     KQEFIRSYVPVPDTDEESVKAAAELINNAERPLVLVGQGVELGSAQEELRIFIEKADMP
                     AGCTLLGLSALPTDHPLNKGMLGMHGNLGPNINTNKCDVLIAVGMRFDDRVTGNLATYA
                     KQAKVIHFDIDPAEVNKNVKVDIAVLGDCKKTLAAVTGLLKKNRHTEWVDSFKEYEAVE
                     EEKVIRPELHPATDSLSMGEVVRAVSEATRHEAILVTDVGQNQMISARYFKYTRERSIV
                     TSGGLGTMGFGLPAAIGATFGRPDRTVCVFMGDGGLQMNIQELGTIMEQKAPVKIICLN
                     NNYLGNVRQWLAMFFNRRYSFTPMLNPDYMKIASAYDIPSKRVFSREELKAAIDEMLST
                     DGPFLLEACVVEEGNVLPMTPPGGSVNQMLLEC"
     CDS             complement(3592..3840)
                     /locus_tag="ctg505_3"
                     /transl_table=11
                     /translation="MEINLVFRKIVRLNHINLLFDLLHHLFDSVLISPRCNRIFMYSFN
                     GRSRNVQTLDVYLPTGKYSGHLIQQSGYIFRMNYNRI"
     CDS             complement(3993..4688)
                     /locus_tag="ctg505_4"
                     /transl_table=11
                     /translation="VLDITNTVYVSVNIDITVFCRQRRNRLIACHLDTRRLFYRAGFIA
                     YIIDDASSMQCQQIGRLTGIQIDHRPYGTGIADLLSILVNDGKVTVGKETIDILHPCLN
                     RELLVLVRHLVQLDRQTGKHPCVIVLVQRSNTKSTVAGMKTCAIQQMIPQHAHGQAAVK
                     IYVKRLCHKLISPYFIFFTHYSCSFLLCLYFASCPSRNSFTRSKQLVVIATRPERTNCR
                     THFKARSSS"
     CDS             4947..5990
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg505_5"
                     /sec_met_domain="IlvN (E-value: 9.1e-47, bitscore: 149.6,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 4.9e-40, bitscore: 128.0,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGTVENVVIRDEFPLEKAREVLKNETIAVIGYGVQGPGQ
                     ALNLRDNGFNVIVGQRQGKTYDKAVADGWVPGETLFGIEEACEKGTIIMCLLSDAAVMS
                     VWPTIKPYLTAGKALYFSHGFAITWSDRTGVVPPADIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAIYQDATGNAMDRTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMG
                     PFHDAIKPVVEKLYHSVKTGNEAQISIDSNSKPDYREKLEEELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(6621..6734)
                     /locus_tag="ctg505_6"
                     /transl_table=11
                     /translation="MHNSNIFSIKDENIYSPTFREVIKYNHIYCFSDSISP"
     CDS             6791..8653
                     /locus_tag="ctg505_7"
                     /transl_table=11
                     /translation="MRSYSCILKVIVVYALLGIVIASCIDKDTDYSRPDDPQTPNDFDY
                     STTQQVQLNVQYEVPEGYQVLFDVYFENPFEIDEEGQVVKRTDVVPKVTRMTDGNGKYA
                     GLEVIPGYLDGDIYIYSSYIGVPTLYKTTLQGNKIQADISWDTMYDFVSAAPTRVESNF
                     TYPKAFNILGDWDENGRPDYLDSEGALSLSQPIMNAINRTLPEDGKCPQKYRQSVDFEI
                     KEPAHVKVRFIGGKSSAYSTFGYYCYKADASIEEIKKAKKYIVFPNTRTGIGIKGGECV
                     ALHYIDENGVDRGTDFPEGIKIGWFIRNAAFWKGNIGAGKGMFYSTPKLNTDGRTHTVA
                     FRINDFVVLSFEDWTDQDYNDVMFNVWSDPIEAIVTPDLPEVIPPGDPDDSSIAYSMTY
                     KGILAFEDNWPSKGDYDLNDVVVKYNSVLSFNTKNEVLSTKDTFTALWSGASYSNSFIY
                     QLNTDKSNVESSLEVDKDLALATIPVFVDVKTETGDNTKTSTVNVTNKFKTPVDHEVLG
                     GAPYNPFISVFKYTGYDRTEVHLVNHKPTEKAKKALFHTGEDLSDLNAGIYYVSASKYP
                     FAINLSDAEVYSTEEREAVDKTYPRFVSWAESNGAKDKDWYLGK"
     CDS             complement(8711..9445)
                     /locus_tag="ctg505_8"
                     /transl_table=11
                     /translation="VILAGDHCQLPPTIKCIEAARGGLDHTLMEKVVQQKPSAVSLLKV
                     QYRMHEAIMRFPSEWFYNGELEAAPEVRNRGILDFDTPMNWIDTSEMDFHEEFVGESFG
                     RINKQEANLLLQELEAYISRIGKARILDESIDFGLISPYKAQVQYLRSKIRGSSFLRPF
                     RSLITVNTVDGFQGQERDVVFISLVRANEDGQIGFLNDLRRMNVAITRARMKLVILGDA
                     TTLTKHAFYRKLITYIKQSGLS"
     CDS             complement(10814..11626)
                     /locus_tag="ctg505_9"
                     /transl_table=11
                     /translation="LVRTELTVHGFRQFHDAIPAGGSQISSHAPVEREKRSGSSYFRPH
                     IANGRFAGSRQGSRSRSEIFDDGVRSSFYGQNPCKFQDDIFRGSPAAQFSGQADTDNPW
                     HFQFPFHTCHHVYGIRTADTDGHHAQSSSIRSVRVGAYHHSTGESVIFEHYLVNDSGAR
                     LPEADAVTRGYIAQKVVNFFVCFGCRSNVLLCSFVRLYQVVTVHGXXXGGGNSHFFFSC
                     IHELKQCHLSSRVLHSDAVGTEIYVVFTPFVVFHIALIEQVGIQNLLG"
     CDS             complement(11759..12667)
                     /locus_tag="ctg505_10"
                     /transl_table=11
                     /translation="VLATGAFSVIFFSHDNGGDSFGFIHFGCARNGSVGVCRTVPHVVR
                     FAIESIHGSHQHIIRNILQMSAKTQPRSRHRNMVGSTFALRLNQQGHIEYILSVPSGER
                     SQQLQALGSRVDVDRCFRPAGGDIAFITGGKSSQGEFFAFRFGQFHFLAVMVHQSVFQR
                     IEAKITGNGQCHRQFGRSNKGVCVRIAVRTFGKVTVEGCDDRVLPRRVVRMTFPLTDAR
                     TAGICHDHGADLHEVIHHSVSFGSGANLFGTRIDDQRGSHTQILFLHLPCKGCGTAEIL
                     VRRVGTRTDQSDFHLTRIAVQ"
     CDS             12674..12976
                     /locus_tag="ctg505_11"
                     /transl_table=11
                     /translation="MEPRFLNVRVILAKSFARIHETNLKKQGMLALTFADKADYDKIQE
                     HDLLSVIGLPDFAPGRNLTVVLHHEDGTKESFEAQHTYNEQQIAWFRAGSALNAR"
     CDS             12991..14181
                     /locus_tag="ctg505_12"
                     /transl_table=11
                     /translation="MNKITMQKDGTLSVPDVPVVPYITGDGVGAEVTPSMQAVVNAAVQ
                     KAYGGKRRIEWKEVLAGERAFNETGSWLPDETMKAFQEYLIGIKGPLTTPVGGGIRSLN
                     VALRQTLDLYVCLRPVRWYQGVHSPVKAPEKVNMCVFRENTEDIYAGIEWEAGTPEAEK
                     FYQFLKNEMGVTKVRFPETSSFGVKPVSREGTERLVRAACQYALDHHLPSVTLVHKGNI
                     MKFTEGGFKKWGYELAQREFGDALADGRLVIKDCIADAFLQNTLLIPEEYSVIATLNLN
                     GDYVSDQLAAMVGGIGIAPGANINYKTGHAIFEATHGTAPNIAGKDVVNPCSIILSAVM
                     MLEYLGWKEAAALIEKALEQSFLDARATHDLARFMPGGTSLSTTAFTREIVERIEK"
     CDS             14207..15550
                     /locus_tag="ctg505_13"
                     /transl_table=11
                     /translation="MKKEYLIYKLSEEMKEATRIDNELFPKFDVKRGLRNEDGTGVLVG
                     LTKIGNVVGYERIPGGGLKPIPGKLFYRGYDVEDISHAIIKEKRFGFEEVAYLLLSGRL
                     PDKEELASFCELINDNMALEQKTKMNIIELEGNNIMNILSRSVLEMYRFDPDADDTSRD
                     NLMRQSIDLISKFPTIIAYAYNMLRHATFGRSLHIRHPQEKLSIAENFLYMLKKDYTEL
                     DARTLDLLLILQAEHGGGNNSTFTVRVTSSTGTDTYSAIAAGIGSLKGPLHGGANIQVA
                     DMFHHLQENIKDWKSVDEIDTYFTRMLNKEVYNKTGLIYGIGHAVYTISDPRALLLKEL
                     ARDLAREKGKEEEFAFLELLEERAIATFGRVKNNGKTVSSNIDFYSGFVYEMIGLPQEI
                     FTPLFAMARIVGWCAHRNEELNFEGKRIIRPAYKNVLDDLAYIPIKKR"
     CDS             15516..15716
                     /locus_tag="ctg505_14"
                     /transl_table=11
                     /translation="MIWLISPSRNADKNKSFYAIITNLRRTSRQSLHVRLGNPQLYILV
                     VPGCTSGVTCFRKNVRCSFNI"
ORIGIN
        1 atagattgaa atgaaaaagc aattacgcag ttcgtttagt acacaaggcc gtcgcatggc
       61 gggagcccgc gcattatggg cagccaacgg catgaagaaa aatcagatgg gaaaacccat
      121 tatcgctatc gtcaattcgt ttacacaatt tgttccggga cacgtgcacc tgcatgaaat
      181 cgggcagttg gtgaaggcgg aaattgagaa gctgggatgc ttcgctgcgg aatttaatac
      241 gattgctatt gatgacggta tcgctatggg acatgacgga atgctttact cgcttccttc
      301 ccgtgatatc atagcggaca gcgtagaata tatggtcaat gcgcacaagg cggatgcaat
      361 ggtatgtatc agcaactgcg ataagattac cccagggatg ctgatggcgg ccatgcgcct
      421 gaatatccct accgtatttg tatccggcgg accgatggaa gccggagagt ggaacggtca
      481 gcatctggac ttgatcgatg ccatgattaa atcggcggac gacagtgtaa gcgatcagga
      541 agtagcgaat atcgaacaga atgcctgtcc tacctgcgga tgttgttccg gaatgtttac
      601 ggcaaactcg atgaactgtc tgaatgaagc tatcggcttg gctcttccgg gaaacggcac
      661 aatcgtggct acgcacgaaa atcgtacgaa actgtttgaa gatgctgcca aactgattgt
      721 ggaaaatgca atgaaatatt atgaagaagg tgacgaaagt gtacttcccc gcagcatagc
      781 tacccgtcag gcattcctca atgccatgac gctggatatt gcgatgggcg gttctaccaa
      841 tacggtgctt cacctgttgg ccgtggcaca tgaggcagga gtcgatttca agatggacga
      901 catcgatatg ctgtcacgca agacaccctg cctgtgtaaa gtcgctccga atactcaaaa
      961 atatcatatt caggacgtta accgtgcggg tggcatcatt gctatcctgg cagagttggc
     1021 aaaaggcggt ctgattgata cttccgttct ccgtgtggat ggcatgtcgc tggcggaagc
     1081 gatcgatcaa tattcaatta ccagcccgaa cgttacggaa aaagcaatga gcaaatattc
     1141 aagtgcggca ggaaacagat tcaatctcgt acttggttct cagggagctt attatcagga
     1201 attagataaa gatcgcgcga acggatgtat ccgtgatctg gagcacgcct atagcaagga
     1261 cggaggcctg gcggtactga aaggaaatat cgctcaggac ggttgcgtag taaaaacggc
     1321 gggtgtagac gaaagcatct ggaagtttac cggacctgcc aaagtattcg actcacaaga
     1381 agcagcctgt gaaggcatcc tcggaggccg agtcgtcagc gacgacgttg tcgtcatcac
     1441 gcacgaaggt ccgaagggtg gtcccggtat gcaggaaatg ctttacccga cttcttatat
     1501 caaatcccgt cacctcggca aagaatgtgc cttgattacc gacggacgtt tcagtggtgg
     1561 aacttccgga ttgagtatcg gacacgtttc tcccgaagcc gctgccggag gtaatatagg
     1621 aaaaatagta gatggagata tcatcgaaat cgacattccc gcccgaacga ttaacgtgcg
     1681 actaacagat gaagaactgg ctgcccgccc gatgactccc gtcacccgtg accgttacgt
     1741 gccgaagagc ctgaaagcat acgccagcat ggtaagctct gccgataagg gagcagtgag
     1801 attaatagac tgatccactt cattatccat tatgaatcat ccattatcca ttaaagaact
     1861 atgagtaagg acttaataac aggcgcagag gcaatgatgc gctctctgga acatcaggga
     1921 gtgactacca ttttcggtta tcccggcggt tccatcatgc ctacgttcga tgccctgtac
     1981 gaccatcaaa atacattgaa ccatatcttg gttcgccatg aacagggagc tgcccatgcg
     2041 gcacaaggct acgcccgtgt atcgggtaaa gtcggtgttt gcttggtgac aagcggcccc
     2101 ggagcaacca atacgatcac aggtattgca gatgcgatga tagacagtac gcctatcgtt
     2161 gtcattgcag gacaggtggg aacaggcttt cttggaacag acgcttttca ggaagtcgat
     2221 ctcgtaggta tcactcagcc aatcgctaaa tggagttatc agattcgccg tgccgaagac
     2281 gtagcctggg cgatagcacg tgctttctac attgccagta gtggtcgtcc tggtccggtg
     2341 gtactcgact ttgccaagaa tgcgcaggtt gaaaaaacga aatacgagcc gacaaagcag
     2401 gagtttatcc gcagctatgt tccggttccc gatacagacg aagaatcggt aaaggctgcc
     2461 gccgaactga tcaataacgc cgaacgcccg cttgtcttgg taggacaggg agtggaactg
     2521 ggaagcgctc aggaagaact gcgtatcttt atcgaaaagg cggatatgcc cgcaggttgt
     2581 accttgctcg gactttccgc attgcctacc gatcatccgt tgaataaagg aatgctgggt
     2641 atgcacggaa atctgggacc gaatatcaat actaacaaat gtgatgtact gattgctgtc
     2701 ggtatgcgtt tcgacgaccg tgtgaccggt aatctggcta cttacgccaa acaagcgaaa
     2761 gtgatccatt ttgacattga tccggcggaa gtaaataaga atgtaaaggt agatattgcc
     2821 gttttgggcg actgcaaaaa gacgctggct gctgtgaccg gactgttgaa aaagaaccgg
     2881 cacaccgagt gggtcgatag tttcaaggaa tatgaagcgg tagaggaaga aaaagtcatt
     2941 cgtcccgaac ttcatcctgc aacggattca ctgagtatgg gcgaagtggt gcgtgcggta
     3001 agcgaagcga cccgtcacga agccatattg gtgacagatg taggtcagaa tcagatgatc
     3061 tctgcccgct actttaaata taccagggaa cgtagtatcg ttacttcggg tggactcggc
     3121 acgatgggtt ttggccttcc ggcagctatc ggagctactt tcggccgtcc cgaccgcact
     3181 gtatgtgtat ttatgggtga cggcggactg caaatgaaca ttcaggaact gggtacgatc
     3241 atggaacaga aagctccggt gaagattatc tgcctgaaca acaattatct cggcaacgtg
     3301 cgccaatggc tggctatgtt cttcaaccgc cgttattcat ttactccgat gttgaatccg
     3361 gattacatga aaatcgcttc cgcctacgat attccttcca aacgtgtctt ttcacgggaa
     3421 gaactgaaag cggccatcga cgaaatgctc tcgacagacg ggccgttcct gctcgaagcc
     3481 tgtgtggtag aagaaggcaa tgtcctcccg atgacccctc cgggcggttc agtcaatcag
     3541 atgttgctgg aatgttaatc cttaatttag aaagttatga gtgataagac attatatacg
     3601 attatagttc attctgaaaa tatagccgga ttgctgaatc aggtgaccgc tgtatttacc
     3661 cgtcggcaaa taaacatcga gagtttgaac gtttctgctt cttccattaa aggagtacat
     3721 aaatatacga ttacagcgtg gactgataag gacactatcg aaaaggtggt gaagcagatc
     3781 gaaaagaaga ttgatgtgat tcaggcgcac tattttacgg aagacgagat ttatttccat
     3841 gagatagcct tatataaggt atctactcct gcttttcagg agactccgga agcatctaaa
     3901 gtgatccgca gatataatgc ccgcattgta gaggtgaatc cggtattctc tatcgtcgag
     3961 aagaacggca tgagtgaaga gattacttcc ctttacgaag aacttcgggc tttgaaatgc
     4021 gttctgcaat ttgtccgttc gggccgtgtg gctattacta ccagctgttt cgaacgtgtg
     4081 aatgagttcc tggacggaca ggaagcgaag tataagcaaa gtaaaaagga acaggagtaa
     4141 tgagtgaaga aaataaaata gggacttatc agtttgtggc agagccgttt cacgtagatt
     4201 ttaacggccg cctgaccatg ggcgtgctgg ggaatcatct gctgaattgc gcaggttttc
     4261 atgccagcga ccgtggattt ggtattgcta cgctgaacga ggacaattac acatgggtgc
     4321 tttcccgtct ggcgatcgag ctggacgaga tgccttacca gtacgagaag ttctcggttc
     4381 agacatgggt ggagaatgtc tatcgtctct ttaccgaccg taactttgcc gtcattgaca
     4441 aggatggaaa gaagatcggc tatgcccgtt ccgtatgggc gatgatcaat ctgaataccc
     4501 gtaagcctgc cgatctgttg gcattgcatg gaggaagcat cgtcgattat atatgcgatg
     4561 aaccctgccc gatagaaaag ccttcgcgta tcaaggtgac aagcaatcag cctgttgcga
     4621 cgctgacggc aaaatacagt gatatcgata ttaacggaca cgtaaacagt attcgttata
     4681 tcgagcacat acttgacttg tttccgatag aactgtatca gacgaaacgt atccgccggt
     4741 ttgaaatggc gtatgtggct gaaagttatt tcggaaatga actctctttc ttctgtgatg
     4801 aggtgagtga aaacgagttt catgtagagg tgaagaaaaa cggcagcgag gtagtatgcc
     4861 gttccaaagt gatatttgaa taatatagag tataaaatca attaataaca gatggcgcaa
     4921 gtcatcaaaa caaaaaaaca aaaaaaatgg cacagttgaa ttttggcgga actgtagaaa
     4981 atgtagttat ccgtgatgaa tttccattgg aaaaagctcg tgaagtattg aaaaatgaaa
     5041 caatcgctgt aatcggttat ggcgtacaag gtcccggaca ggctctgaac cttcgtgata
     5101 acggtttcaa tgtaatcgtt ggtcaacgcc agggaaagac atatgacaaa gcggttgctg
     5161 acggatgggt tccgggtgaa actttgttcg gtattgaaga agcttgcgaa aaaggtacga
     5221 tcattatgtg cctgttgtct gatgcagcag taatgtctgt atggcctact atcaagcctt
     5281 acctgactgc aggaaaagct ctttatttct ctcatggttt tgctattaca tggagtgacc
     5341 gcacaggtgt agttcctcct gcagatatcg acgtaatcat ggttgctcct aaaggttcgg
     5401 gtacatcctt gcgtactatg ttccttgaag gtcgcgggtt gaactcttca tacgctatct
     5461 atcaggatgc aacaggcaac gctatggaca gaacaatcgc attgggtatc ggtatcggtt
     5521 caggttattt gttcgaaaca actttcatcc gcgaagctac ttccgacctg acaggcgaac
     5581 gtggttcatt gatgggagct atccagggtc tgttgctggc acaatacgaa gtgttacgtg
     5641 aaaacggtca cactccttcc gaagcattca acgaaactgt agaagagctg actcagtcat
     5701 tgatgccgtt gtttgcaaag aacggtatgg actggatgta tgctaactgc tctactactg
     5761 ctcaacgtgg tgccctcgac tggatggggc ccttccacga tgctatcaaa ccggtagttg
     5821 aaaagttgta tcacagcgtg aagactggta acgaagcaca gatttcaatc gactctaact
     5881 ccaaaccgga ttatcgtgag aaactggaag aagaactgaa agcattgcgc gaaagcgaaa
     5941 tgtggcagac tgccgtgaca gttcgtaaac ttcgtccgga aaataattaa tcagacttat
     6001 actatataag tttttcaaaa ggcgggaaaa gcgtattttc ccgccttttc tatgtagata
     6061 ccggtctttt gagtaataga aaaaggatga aagtagaaaa aaagattaaa agatactgat
     6121 aatataggtg aaaaagagca tttatgatta cctttacggc aacaaataaa acagaatagg
     6181 caatgaagaa actttttact tacagaagat cgatacgtat gaagatgatt tcttctttaa
     6241 taaatagtat atcagaatgt tacattaaaa gatatttaag ttattctcta ccgaatggta
     6301 gctgtaatac catttcaagt cctttttata tttcgtgttc cattagtgat tcgttgatat
     6361 gatgcagaat tttattctgt agcaggaaaa agtatgcgtt aaattgaatt taagacagag
     6421 cttttggaac agaatttagt gggaaaataa cattgtttgt tttgtttgta aatgggagtc
     6481 ctctttcgtg agaaaggggg cttctttttg atatgctcaa cataggtgca tgttttagga
     6541 ttgatccctc tcatccataa atatctgaac gttggtgttg tggtaggcac taggattgca
     6601 tcaactcctg ccggagttgc tcaaggggag attgagtctg aaaaacagta aatatggtta
     6661 tattttataa cttcacgaaa ggttggagaa tatatatttt cgtcttttat tgaaaaaata
     6721 ttagaattat gcataagata tgcaagtttg tatttatctt tgcttcaaca aactaaaaca
     6781 aattttaaaa atgagaagct attcatgtat tttgaaagta atagttgttt atgccttact
     6841 tggtattgtt attgcaagtt gtatcgataa agatacagac tattctcgtc cggatgaccc
     6901 ccaaactcct aatgactttg attacagtac aactcaacag gtacagttaa atgtgcagta
     6961 tgaggttcct gaaggttatc aagtactctt tgatgtctat tttgagaatc catttgaaat
     7021 agatgaagaa ggccaagttg taaaacgtac tgatgttgtg ccgaaagtga ctagaatgac
     7081 tgatggaaat ggtaaatatg ccggcttgga agtgattccc ggttatttgg atggtgacat
     7141 ttatatttat tcttcttata tcggagtgcc tacgctttat aagacaactc ttcagggaaa
     7201 taagattcaa gctgatatat cctgggatac tatgtatgat tttgtttctg cggctccaac
     7261 acgagtggaa agtaatttta cgtatccaaa ggcttttaat atattgggtg actgggatga
     7321 aaatggtcgt cctgattatt tggatagtga gggagcgcta agcttgtctc aaccaataat
     7381 gaatgcaata aaccgtacac ttccggaaga tgggaaatgt ccgcaaaaat atcgtcagtc
     7441 ggttgatttt gaaataaagg aacctgctca tgtaaaggta cgttttattg gcggtaagag
     7501 tagtgcttac agtacatttg gatattattg ttacaaggcg gatgcttcta ttgaagaaat
     7561 aaagaaagcc aagaaatata ttgtatttcc taatacaaga actggaatcg gtataaaagg
     7621 aggagaatgt gttgcgttac attatattga tgaaaatggg gtggatcgtg gaacagattt
     7681 tcccgaaggt ataaaaatag gctggttcat tagaaatgca gctttttgga aaggaaatat
     7741 tggtgccgga aaaggaatgt tctattcaac tccaaagttg aatactgatg gacgtactca
     7801 tactgttgct tttagaatta atgattttgt tgttctctct tttgaagact ggactgacca
     7861 ggattataat gacgtgatgt ttaatgtatg gtcagaccct attgaagcta ttgttactcc
     7921 ggatttgcct gaggttattc ctcccggaga tcctgacgat agttcaattg catatagtat
     7981 gacctacaaa ggtattttgg cttttgagga taactggccg tccaaagggg attacgattt
     8041 gaatgatgta gttgtaaaat acaattctgt attaagtttt aatacaaaga atgaagtgct
     8101 ttctacgaaa gacacgttca ctgcattgtg gtccggagcc tcttatagca atagttttat
     8161 ttatcagtta aatacagata aatcgaatgt cgaatcgtct cttgaggtag ataaggattt
     8221 ggctcttgct actattccgg tatttgtgga tgttaaaact gagacaggtg ataatacgaa
     8281 gacatcaaca gtgaatgtca cgaataaatt taagactccc gtcgatcacg aggtcttagg
     8341 aggagctcca tataatccat ttatcagcgt ttttaagtat acgggatatg accggacaga
     8401 agtacattta gtcaatcata aacctacgga gaaagcgaag aaagccttgt tccatacagg
     8461 tgaggattta tccgatttga atgctgggat ttattatgta tctgcttcaa aatatccgtt
     8521 tgcaatcaac ttatctgatg cggaggtcta ttcgacggag gaaagggagg cagtagacaa
     8581 gacttatccc cgttttgtct cctgggctga gtctaatgga gcaaaggaca aagattggta
     8641 tttgggaaaa taatatagtt tgttttgttt gtaagtgggg cttccttcga ctgaaggagg
     8701 ctctcttatt ttatgatagg ccgctttgtt tgatatatgt aattaatttc cggtagaacg
     8761 catgcttggt aagcgtcgtt gcatccccta aaatcacgag tttcatccgg gcgcgggtaa
     8821 tggctacgtt cattcgtctt aaatcattca gaaaaccgat ctgtccgtcc tcgttcgccc
     8881 ggacgaggct gataaagacg acatcccgtt cctgtccctg aaagccgtct accgtgttga
     8941 ccgtgatgag gctgcggaaa gggcggagaa aactgcttcc tctgatttta cttctcaggt
     9001 attgcacttg cgccttgtag ggcgaaatca gaccaaagtc gatgctctcg tccaggatgc
     9061 gtgctttgcc gatccggctg atataggctt ccagttcttg cagtaacaag ttggcttcct
     9121 gcttgttgat gcgcccgaag ctctcgccta caaactcttc gtggaagtcc atttccgagg
     9181 tatctatcca gttcatggga gtgtcgaagt caaggatacc ccggttgcgc acttccggtg
     9241 cggcttccag ttccccgttg tagaaccatt cggagggaaa gcgcatgatt gcctcgtgca
     9301 tccggtattg cactttgagc agcgagacgg cagaaggttt ttgctgcacg actttttcca
     9361 ttaaagtatg gtccagtccg ccacgggcgg cttcgataca tttgattgta ggagggagct
     9421 ggcaatggtc gccggcaaga atcacacggt cggcctttcg gatggcgatc caacaggcgg
     9481 cttcgagtgc ctgggcggct tcatcgataa ataaggtggg gaaacgcctt ccgttgagca
     9541 aacggtgatt gctgctgacc agcgtagaag caatcacacg ggcactgtcg aaaagatcgg
     9601 cgttgatcag gatttccagt tcggtggcac ggtcgcggag gcggctcatc cggctgcgta
     9661 ttccttccct ttcggagtaa cttccccgac gcatccggct gcccatttca cggattgatt
     9721 ttcggattcc ccaaagttcg gggtagctcg gatgattctc aaagcggcgt tcgtaggtga
     9781 aagagagcat tttatcatta acacgcgtag gattaccaat gcggagcaca ggaacacccc
     9841 ggtccaccag tttctcacaa atccagtcca cggccgtatt actttgggcg cagaccagca
     9901 cctgcggttc gcggtgaagc gtttcgtaaa tggcttccac aagcgtggta gtctttccgg
     9961 ttcccggagg gccgtgtacg atggcgacat cgcgtgtgca taacactttg tttacggctg
    10021 tctcctgcgt gctgttcagc cacgggaaac ggacgggata caattcgcgg aatcccggct
    10081 tttgtgttcc cagcaaggtg tcccggagtt cggcaaggcg gttgcctttg gcgcggatcg
    10141 tgtcttctag cgcttcgaac atggcacgat aggacgtttc atcgaaataa agttgtacac
    10201 ccagcacctc ttccgtttgc agttccagca atgcgcctgc actgggaagc acgaccacca
    10261 tccgttcatc gtccgcataa ctcaccgttg caatgaaatt catataattc actttcccgt
    10321 caaatgactg acggaaaaag cagacgggac gaccgaattc gaaggaatgc tcgatttctt
    10381 tattttcggt gcgtgtaata tctattacaa gttgatttag agaattatag taacttcgac
    10441 cgggagaggc gggataccag cacagaccac gtttcacttt gcgggcgaca cccattgttt
    10501 cagtctgccg cttgaattcc tccttttcgt gttcatactc catgcgtagc aggagttgct
    10561 gttgctgaag gtcgatgatt ggacttttcg gatgattatt cataatagat gcaaaggtag
    10621 taaatcttcc tcctgagacg aaaatatatt tcattttgtt aaacattcct cgaacgccgt
    10681 tcgttatttt tatagataga ctaaaaaaaa taaaagcaat atggtgtatg atttgactat
    10741 gttagaggct ttttattctg cttataaagg aaaagtggaa cacgtgcggg ctgttttgaa
    10801 acgccctttg acgttagccg agaagattct gtatgcccac ctgttcaatg agggcgatgt
    10861 gaaaaactac aaacggggtg aagactacgt aaatttccgt cccgaccgcg tcgctatgca
    10921 ggacgcgact gctcagatgg cattgcttca attcatgaat gcaggaaaag aaaaagtggc
    10981 tgttccctcc accnnnnnnn nnnccgtgca ctgtgaccac ttgatacaag cgtacaaagg
    11041 agcaaaggag gacattgcta cggcaaccaa aacaaacgaa gaagtttacg actttttgcg
    11101 cgatgtatcc tctcgttacg gcatcggctt ctggaagccg ggcgccggaa tcattcacca
    11161 ggtagtgctc gaaaattacg ctttccccgg tggaatgatg gtaggcaccg actctcacac
    11221 tccgaatgct ggaggattgg gcatggtggc catcggtgtc ggcggtgcgg atgccgtaga
    11281 cgtgatgaca ggtatggaat gggaactgaa aatgccaagg attatcggtg tccgcctgac
    11341 cggaaaattg agcggctgga cttccccgaa agatgtcatc ctgaaacttg cagggattct
    11401 gaccgtaaaa ggaggaacga actccatcat cgaatatttc ggaccgggaa cggcttccct
    11461 gtcggctacc ggcaaagcga ccatttgcaa tatgggggcg gaagtaggag ctaccacttc
    11521 gcttttcccg ttcgacgggc gcatggctac ttatctgaga gccaccggca gggatcgcat
    11581 cgtggaactg gcggaagccg tggactgtga gctccgtgcg gaccaacagg tgacggacga
    11641 accggaaaag tactacgacc gtgtcatcga catcgatttg tctacgctcg aaccttatat
    11701 caacggccct ttcacaccgg atgccgctac ccctatttct gaatttgcag aaaaagtatt
    11761 actgaacggc tatccgcgta agatggaagt cggactgatc ggttcgtgta ccaactcttc
    11821 ttaccaagat ctcagccgtg ccgcatccct tgcaaggcag gtgaaggaaa agaatctgag
    11881 tgtggcttcc ccgttgatca tcaatccggg ttccgaacaa attcgcgcca ctgccgaaag
    11941 agacggaatg atggatgact tcatgcagat cggcgccgtg atcatggcaa atgcctgcgg
    12001 tccttgcatc ggtcagtgga aacgtcatac ggacgacccg acgcggaaga actcgatcgt
    12061 cacatccttc aaccgtaact ttgccaaacg tgcggacggc aatccgaaca catacgcctt
    12121 tgttgcttct cccgaactga cgatggcact gaccattgcc ggtgatcttt gcttcaatcc
    12181 gctgaaagac agactgatga accatgacgg cgagaaagtg aaactggccg aaccggaagg
    12241 cgaagaactc cccttgagag gatttacctc cggtaatgaa ggctatatcg cccccggcgg
    12301 gacgaaaaca gcgatcaacg tcaacccggc ttcccaacgc ctgcaactgc tgactccttt
    12361 ccccgcttgg gacggacaag atatactcaa tatgcccctg ctgattaagg cgcagggcaa
    12421 atgtactacc gaccatattt cgatggcggg accgtggctg cgttttcgcg gacatttgga
    12481 gaatatttcg gataatatgc tgatgggagc cgtgaatgct ttcaatggcg aaacgaacaa
    12541 cgtgtggaac cgttcgacaa acacctacgg aaccgtttcg ggcacagcca aaatgtataa
    12601 atccgaagga atcccctcca ttgtcgtggc tgaagaaaat tacggagaag gctccagtcg
    12661 cgagcacgcg gcaatggaac cccgtttcct gaatgtgcgt gtgattctcg ccaagagctt
    12721 cgcccgtatc cacgaaacga atctgaaaaa gcagggcatg cttgccctta cctttgcgga
    12781 taaagcggat tatgacaaga tacaggagca cgacctcctt tcagtcatcg gcttgcccga
    12841 ctttgctccg ggacggaatc tgaccgtcgt tcttcatcac gaagacggaa cgaaagagag
    12901 ttttgaagcg caacatacat acaacgaaca gcagattgcc tggttccgtg ccggctctgc
    12961 cttgaatgcc agataattaa aatgatagaa atgaacaaaa taaccatgca aaaagatggt
    13021 acgctgtcgg tgcccgatgt gcctgtcgta ccttatatta ccggagacgg agtaggagcg
    13081 gaagtgactc cgtcaatgca agccgttgtg aacgcggctg ttcagaaagc atacggcggc
    13141 aaacgtcgga ttgaatggaa agaagtgctg gcgggcgaac gcgctttcaa cgagacaggc
    13201 tcttggctgc cggatgaaac gatgaaggct ttccaagaat atctgatcgg catcaagggt
    13261 ccgctgacga cccctgtcgg cggtggaatc cgttctttga acgtagcttt gcgccaaacc
    13321 ttggatttat atgtttgttt gcgtccggtt cgttggtatc aaggcgttca ttctccggtg
    13381 aaagcaccgg aaaaagtgaa catgtgtgtg ttccgtgaaa atacggagga tatatatgca
    13441 ggaatcgagt gggaggcagg tactcccgaa gccgaaaagt tctatcaatt cctgaaaaac
    13501 gagatgggag tgacgaaagt ccgcttcccc gagacctctt cttttggggt gaaacctgtt
    13561 tcccgtgagg gcacggaacg tcttgtgcgg gctgcctgcc agtatgcgct cgaccatcat
    13621 ctgccttctg tgacactggt gcacaaagga aacattatga agttcaccga aggaggtttc
    13681 aagaaatggg gctatgagct ggcgcaacgt gagtttggcg acgcgctggc agacggccgg
    13741 ctggtgataa aggactgcat tgccgatgct tttctgcaaa atacattact gattcccgaa
    13801 gagtattccg tgattgccac gctgaacctg aacggagact atgtttccga ccagttggcg
    13861 gcaatggtag gcggcatcgg cattgctccg ggagcaaata ttaactacaa gacggggcac
    13921 gccatttttg aagcgactca tggaaccgcc cccaacattg ccggaaagga tgtcgtgaat
    13981 ccttgttcta tcattctttc ggcggtgatg atgcttgaat atctgggatg gaaagaagcg
    14041 gccgcgctta tcgaaaaggc gctggaacag agtttcctcg atgcccgtgc cacgcacgat
    14101 ctggctcgct ttatgccggg aggtacatcc ctgtctacca ccgctttcac acgcgaaatt
    14161 gtggaaagaa tcgaaaagta aatgtaacga ttaaaaacga agtattatga agaaagagta
    14221 tttgatttac aagctctccg aggagatgaa agaggcaacc cggattgaca atgaattgtt
    14281 ccccaagttt gacgtgaagc gtggactacg taatgaagac ggcaccggtg tattggtagg
    14341 tctgacaaag attggtaatg tggtgggtta cgaacgtatc cccggcggcg gtctgaagcc
    14401 tattccggga aaattgttct atcgaggcta tgatgtggaa gacatttccc acgccatcat
    14461 caaggaaaaa cgtttcggct tcgaagaagt ggcttatctg ctactctccg gtcgtctgcc
    14521 ggacaaggaa gaactggctt cgttctgcga actgatcaat gacaatatgg cgctcgagca
    14581 gaagacgaaa atgaatatta tcgagctgga gggaaataat atcatgaata tcctttcgcg
    14641 cagcgtactc gaaatgtatc gtttcgatcc cgatgccgac gatacttccc gcgacaatct
    14701 gatgcgccag agtatcgatc ttatctccaa gttcccgacc atcattgcgt atgcttataa
    14761 tatgctccgc catgctacat tcggccgttc cctgcatatc cgtcatccgc aggaaaaact
    14821 ctctattgcc gagaatttcc tctatatgct caaaaaagat tatacggaac tggatgcccg
    14881 tacgctcgac ttgctattga ttttgcaggc agaacatggc ggtggtaaca actcgacttt
    14941 cacggttcgt gtgacttctt ccaccggaac agatacatac tcggccatcg ccgcaggtat
    15001 cggttcgttg aaaggcccgc ttcacggagg cgcgaatatc caggtggccg atatgttcca
    15061 tcacttgcag gagaacatca aggactggaa gagcgtggac gagatagata cctatttcac
    15121 acggatgctg aataaggaag tgtataataa gaccggattg atttacggta tcggtcatgc
    15181 tgtttatacg atttccgatc ctcgtgcgct gttgctgaaa gaactggctc gcgaccttgc
    15241 ccgtgagaaa ggaaaagaag aggagttcgc tttcctcgaa ctgcttgaag agcgtgccat
    15301 cgctactttc ggacgtgtga agaacaacgg aaagacggtt tccagcaata tcgacttcta
    15361 ttcgggcttc gtatatgaga tgattggttt gccgcaggag attttcactc cgctgtttgc
    15421 catggctcgt attgtcggct ggtgtgcgca ccgcaatgaa gaactgaact tcgagggcaa
    15481 acgcattatc cgtccggctt ataaaaatgt tcttgatgat ctggcttata tccccatcaa
    15541 gaaacgctga taagaacaaa tccttttatg caataataac taacctcaga cgtacatctc
    15601 ggcaatccct gcatgtacgt ctcggtaatc cccagttgta catcttggta gtacccggtt
    15661 gtacgtctgg ggtgacttgt ttcaggaaga acgtccgatg ttcatttaac atttaacact
    15721 ttgcggctgc tgtatttttc atccgatgga ggctaaggca tttatcgttg gtagaaaggg
    15781 cacagcctgg caggtagaaa cgccctttta acgctacgtt aaaagggcgt ttctacaacc
    15841 gatgaattat acattctatt tctttggata tcagtgaact atgatctttc cctttgctgg
    15901 aggagagatt atggacaggt gacctgttga gaacaaactt gttattttaa taattactgt
    15961 cgattgagtc tttgctacta ttattgggat
//
