LOCUS       c00007_gnlPro..        15016 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OBEBBNPO_7.
ACCESSION   c00007_gnlPro..
VERSION     c00007_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 18:41:23
            Original ID  :: gnl|Prokka|OBEBBNPO_7
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15016
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15016
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[948:5016]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      949..5016
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..15016
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15016
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             complement(2..760)
                     /locus_tag="ctg7_1"
                     /transl_table=11
                     /translation="MLITIIILVLSAVFFVNGKIRSDLVALCALVALLIFQILTPDEAL
                     SGFSNSVVIMMVGLFVVGGAIFQTGLAKMISSHILKLAGKSELKLFLLVMLVTSAIGAF
                     VSNTGTVALMLPIVVSLAVSANMNPSRLLMPLAFASSMGGMMTLIGTPPNLVIQNALTS
                     AGFPPLSFFSFFPVGIICVAVGTLVLLPLSKWFLSKRGKNGDNNVHSGKSLKQLVKEYG
                     LSSNLFRLRVVGDSCLLHNLPQGRIFFRTVS"
     CDS             949..1356
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg7_2"
                     /sec_met_domain="HBT (E-value: 1.4e-14, bitscore: 44.6,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMEEITCKPDYSNSMAEHLGIRFLPPTENAVHAEMPVDHRTSQPF
                     GMLNGGASLALAEIVAGHGSMSLCREGEYACGVQVSGNHLSAVPVGGKVFATGKLIHRG
                     RSSHIWNIDITTPQGELVSTVRVVNFILKKK"
     CDS             1353..2522
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg7_3"
                     /sec_met_domain="Chorismate_bind (E-value: 2.8e-57,
                     bitscore: 184.4, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLPDIHTQKLLDCLTHSRLGFALYRLPWTDECYLVLQTSGDVEQ
                     LADIQELNEKKGFVMAPFRISEEHPLVLIRPDVTAYDWNEISEALSSLECVDTLLTCKS
                     RQNELSPFVSEETDKEQYTRAFGRFITPLQEKQFQKLVLSRSSARHIGDDFSPLGAFVR
                     ACNNYPRMMIYLCHTPASGTWLGSTPEILLSGQGKEWHTVALAGTMPMQDEVMPTNWDK
                     KNQEEQGYVADYIRRIAKKFGNKMTEKGPYTARAGQLVHLKTDFYFLLKNTDHIGDLLQ
                     ELHPTPAVCGLPKEEAFRFILNNEGYDRSYYSGFTGWLDTEGHTDIYVNLRCMEIKPGE
                     AILYAGGGILASSEVESEWVETGDKMNTMRSILHPDFISKQMETIKVEE"
     CDS             2522..4195
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg7_4"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2e-07, bitscore:
                     21.2, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSDKKNILQLVALLKAHGVRKIVLCPGSRNAAIVHTLANIEDFT
                     CYSVTDERSAGFFAIGLSLQGGGPAAVCCTSGSALLNLHPAVAEAFYQQVPLIVISADR
                     PAAWIGQMDGQTLPQPHVFGTLVKMSVNLPEVHTEEDEWFCNRLINEAILETTHHGKGP
                     VHINVPISEPIYRFTAKTLPEARVITRYQGLSVYDRDYKELIERLNKYNKRMVVVGQMN
                     LIYLFEKKYVKPLYKHFAWLTEHLGNQTIPGIPIKNFDAAVYSMTPERQEDMAPEILIT
                     YGGHIVSKQLKKYLRNHPPREHWHVAADGKIADLYGCLTTVIEMDPFEFLEKIAFLLDN
                     KPTHYPLMWENYCKTIPMPDLAYSEISVIGKLIQALPEPCALHLANSSTVRYAQLFTVP
                     PRVEICCNRGVNGIEGSLSTAIGYAAASSKLNFIIIGDLSFFYDMNALWNQNYGANIRI
                     LLLNNEGGEIFHTLPGMDKSSRSREFITAEHYTTAKGWAEERGFIYMKVTGEEELEEAM
                     QPFTSPETRMQPMLLEVFTDKEKDTTLLREYYHGLKNKNE"
     CDS             4195..5016
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg7_5"
                     /sec_met_domain="ECH_1 (E-value: 1.1e-85, bitscore: 277.1,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METRKWKTIKEYQDILFDFYNGIAKITINRPRYRNAFTPTTTSEI
                     SDALYYCRECQDINVVVLTGAGDKAFCSGGDMHVKGHGGYIGTDGVPRLNVLDVQKQIR
                     SLPKPVIAMVNGYAIGGGHVLHVVCDLTIASENAIFGQTGPKVGSFDAGFGSSYLARIV
                     GQKKAREIWFLCRQYSAQEALEMGLVNTVVPFDRLEDETVAWAEKMMEHSPLALRMIKA
                     GLNAELDGQAGIQELAGDATMLYYMTEEAQEGGKAFLEKRKPRFQDYPKFP"
     CDS             5037..5420
                     /locus_tag="ctg7_6"
                     /transl_table=11
                     /translation="MDIEEFRKYCLSLGDVSEKMPFGKFAARYDSILAFYVYGHMFCFI
                     DIDNFTFVNVKSTSDEIEYIKERHVSVGNPINQSLKHWLQLNFDGDIPDTSIYTWVQRA
                     FEIVRDKYTKPTTHKKKCSKPKL"
     CDS             5399..6454
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg7_7"
                     /sec_met_domain="MR_MLE_C (E-value: 1.1e-28, bitscore:
                     90.5, seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQTQIIKKQLHFKQPAGTSRGVYTTRDVWYILLTDTGSRHYGVG
                     ECAPLPALSCDDIPSYDEVLATACKNLEKNGEIDREALLPYPSILFGMETALLHFRARS
                     LQFWHTPFSKGKEGIPINGLIWMGNFDEMYRRIGEKMQQGFRCIKLKIGAIDFEKELEL
                     LAHIRRHFTPAQIELRVDANGAFSPTDTLEKLHRLSEFQLHSIEQPIRAGQWDEMARLC
                     AATPFPIALDEELIGINRRDRKIELLETIRPQYIILKPSLHGGISGSEEWMELAAERGI
                     GSWVTSALESNIGLNAIAQWCATLQPALPQGLGTGLLFTDNIDYPLHIEGDCLWFHPEE
                     QEPDLLNWLKQ"
     CDS             6451..7536
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 57.3; E-value:
                     3.6e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg7_8"
                     /sec_met_domain="AMP-binding (E-value: 1e-18, bitscore:
                     57.3, seeds: 145, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding_C (E-value: 1.9e-08, bitscore:
                     25.5, seeds: 272, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKFCTNRNKQTILIESIPYSNWEIEMVRMNIPADNRSFRQELFS
                     FLSEWFDPADTLLVHTSGSTGKPKELYVEKERMMESACLTCSFLGLQKEDSALLCMPLQ
                     YIAGKMVVVRALVAGLDLLPVTPSGHPLKDLTKAPVFAAMIPMQVYNSLQVPEERAILQ
                     QIRHLIIGGGPIDSQLNAALKDFPHAVWSTYGMTETLSHIALRRLNGPEASDWYTPFES
                     IQIRLSKENTLVIYAPEICGKELVTNDIAEINGQNQFRILGRKDNTINTGGVKVQIEQV
                     EAALKEHLSVPFLITSAPDEKFGEIIVLLAEGQLPDDIEQTCTHQLPPYWRPKRFVPVF
                     KLPLTETGKPDRAIAKLLAQK"
     CDS             7792..8679
                     /locus_tag="ctg7_9"
                     /transl_table=11
                     /translation="MLYNTPKPQDTKEGLSDQDFSIYMDAHTVPFSKYPSYLPEGVLGM
                     CTEGNAEIQIGLRKYVICANDILIFMPGFLVSFIKSSLTFTIDYCTFSNALFYDVINGS
                     IKRFPTGFHTYTQTHCIYSLSQEKAEQFSLYFRLLYNRATSPTYLFTKESITNLLKLPF
                     LELYADYYSTVKEHKVTTLHKEEIGYFFLDLLLKHYKENKEVAFYAEKLHVSSKYLTEA
                     LTLVSGKSPKEWIIHYTLQEIYALLENPSISIQEIVQRTRFANLATLRRFFKRHTGTSL
                     LQYRKQDLYKNNQQ"
     CDS             complement(8742..8918)
                     /locus_tag="ctg7_10"
                     /transl_table=11
                     /translation="MELPDDPMMLFSMVNMKLRDCYHSLDELCDDMDVDKELLVKKLKA
                     AGFEYSKENNKFW"
     CDS             complement(9033..11312)
                     /locus_tag="ctg7_11"
                     /transl_table=11
                     /translation="MLRDYQIEMKTRLMEAWKAHRSVMVQMPTGTGKTHLLASVVSEFV
                     SSAGSGVWLIAHRRELVEQMEETLAKYGIRREDTPVRVMSVQWLSRHWNEAGDAPGLIV
                     IDEAHHALAASYTEMWKRYPAAKKLGVTATPCRLNRRGFTELFEVLVTSWSIAEFIEKG
                     VLSVFDYVSIRPGSEEQRLIDGLEKRGVDGDYQVKEMDAVLNRRPGIERLYRSVRQFAS
                     GKKGMVYAISIEHARRIAEYYSRRGVNAVAVDSKTPAMERKRMVEEFRHGKIEVLVNVD
                     VFSEGFDCPDVEFVQLARPTLSLAKYLQQVGRGLRRSEGKEACMLIDNVGLYRIFGLPT
                     QRWNWDAMFRGRMAGKGSLPGRMNCDASVTAFPVVERPAEAGGDLVVVMEHGRLLSSIR
                     EQALPDEKEQSPSCRLRAFVDKETGLWGLEKGDEMLPDASFKEVLSIKGRFAVGRLRNG
                     CVRVLDDTGALVAELGHCCEVRLLKDDLLQVRHVGNSVSYVDLRNGRCYAVRPRVLRYG
                     SIELLQVNRTYYSRTRQVYANTCGLPSSSIVWMGFYVKMYDGRVPSRCRRMEDGGFCCE
                     PQVCLLEGDEERAYYLSGRLPDQSIVVMDEEGRYYHVEKGHGKRYVACNRPSDRSEDFD
                     EAVALLRRQADERVEKHLQEEKCETERKRQRIISRSVEAVPFQIGVKWGLRTAEQILIP
                     PVYRRILRPVGGYCAYQDSSCQWGVLTVDGRIIIRARYMEVEIDRDGTARLTLVPGKME
                     TVKLTD"
     CDS             complement(11368..11817)
                     /locus_tag="ctg7_12"
                     /transl_table=11
                     /translation="MMINIYGGNNLIAPVASSAIQNFYGDRGDEVADQPEDSEKTENTE
                     SVADEKPAQEPAELSDDEFYVSVYIPDIKVMRAYKILLGECTTARELAVVVGKMLVDEN
                     CRNVDKHTVVKAAFIKSLLPFAKRLVSGGTIANIRAQINNMLASK"
     CDS             12021..12590
                     /locus_tag="ctg7_13"
                     /transl_table=11
                     /translation="MKEYIMSFFNAPVTNKIPTCICSVAGLHTYISTNPQLEELTRKVR
                     AGLGDKQAFRKNKQTLLPYVTPAGIFSYCKEQCMQVPSGLFVIDIDELASTEEAAMWRD
                     RLFADEVLHPVLSFVSPGNQGVKLFIPYRINPFLSVEESFDNALHTAWEYLEWKYELKV
                     DRANADLSRACFLSHDGEAKINNHKY"
     CDS             12594..14537
                     /locus_tag="ctg7_14"
                     /transl_table=11
                     /translation="MNDSISILEQLVTAIEQAGVNVAPTYQEYMPLAFAIANCCGEEGR
                     TRFHRICRISEKYHHDEADKLYGHALTKGTGRNSLGTVFHLAEVAGVKMDPKLANLQNL
                     QSLHTHTRARVSYNAHPDASDGTPPDAVFTDTASPLSDGVPKAILPARLPSFPDYRWPA
                     FLQGIIDCGNSPAQRDILLLGAATVLGSTLNKLVSFVYGRKHKYPCLQVFVTAPPASGK
                     GALTWVRRLAEPIHNALLDTYREKIKTYRMEKTKWDTLGKEKVNTPEPEQPQLKMLLIA
                     GDNTGTGIQENLMDSGGVGLICETEADTVSTAIGGDHGHWSDLLRKCFDHDRLAYNRRT
                     NHEYRECNVTFLCVLLSGTPAQIKPLIPSAENGLFSRQLFYYMPAIEEWEDQFNEADTD
                     YDSRFLEWGAQWKEVLNAITASVSNINMKLTHEQKEIFNFHFARVFGRASAIHGNQMKS
                     AVTRIAINIFRIISIIALLRSLESLLPGGERSGEPQENIVRTLLNCPGLTPSAHIPQEN
                     IADGIVPQFNLSIRTDDFYAVLALVEPLYRHACHILSLLPAGPPSAPSANMTPETLFDC
                     LPLRFTRNEAIDKGEQVGVPAGSVDSLLKRMTERGQLVKVGRGEYEFNARMHTRTCVGV
                     RESASSASLQDS"
     CDS             14555..14779
                     /locus_tag="ctg7_15"
                     /transl_table=11
                     /translation="MKDFLYFPSMTKGSLALLYFPGSNPRIATRHLMRWINGCPPLMEE
                     LSATGYYTSQKVFTSRQVTLINRHLGSPG"
ORIGIN
        1 tgctaactgt tctaaaaaat attcttcctt gagggaggtt gtgcaacaaa cacgagtcac
       61 cgaccaccct caaccggaac aaattactgg atagcccata ttccttcacc aactgtttca
      121 gggatttgcc cgaatgaaca ttgttgtctc cgtttttccc ccgtttcgaa agaaaccatt
      181 tactgagcgg aagcaacacc aaagtaccca ctgccacaca aataatccct accggaaaaa
      241 aagagaagaa cgaaagcgga ggaaaaccag ccgaagtcaa cgcattttga ataacaaggt
      301 tgggcggcgt accaatcagt gtcatcatac ctcccatact gctggcaaac gccaacggca
      361 taagcaaacg actgggattc atgttggcac tgactgccag actgaccacg ataggcaaca
      421 tcagagccac cgtacctgtg ttgctcacaa aagccccgat agcagaagtc accaacatta
      481 caagcaagaa taatttcaat tcactcttac ccgctaattt cagaatgtgt gaactgatca
      541 ttttggcaag tcccgtctga aaaatcgctc cgccaaccac aaacagcccc accatcataa
      601 tgacgaccga attggagaat ccggacaaag cctcgtcagg cgtcaatatc tgaaaaatca
      661 acaaagccac taaagcacaa agagccacaa gatccgaccg tatcttgcca tttacaaaaa
      721 atactgcgga cagtacaagg ataataatcg taatgagcat aggtattaaa ttattgtttt
      781 attcattcgt tgttgcattt gtacgaattc tttttgcaaa ataaaaaata tattccgaaa
      841 atagaaacaa accccgaatg tttttgttct taaaagaaca acattagcga cattttcatc
      901 taaaatttat gtatttttgt agccctatag aaaagaacag acatacaaat gatggaagaa
      961 ataacctgca aacctgatta ttcgaattcg atggcggaac atctgggtat ccggtttcta
     1021 ccccccaccg agaatgcggt acatgccgaa atgcctgtag accatcgtac ttcacaaccc
     1081 tttggtatgt tgaacggcgg cgcgtcactg gctctggccg agattgtggc aggacatggc
     1141 tccatgtcgc tatgccggga aggcgaatat gcctgcggag tacaagtaag tggaaatcat
     1201 ctgtcggccg tacccgtcgg aggcaaagta ttcgccaccg gcaaactgat tcaccgcggc
     1261 agatcctcgc atatatggaa tatagatatc accactccac agggagaact ggtttctact
     1321 gttcgtgtcg ttaatttcat actgaaaaag aaatgaatct accagatata catacgcaaa
     1381 aattattgga ttgcctgaca catagccgcc tcggtttcgc cctctaccgg ttaccttgga
     1441 cagacgaatg ctacctggta ttgcaaacct cgggcgatgt ggaacaatta gcggacattc
     1501 aagaactgaa tgaaaaaaag ggatttgtca tggctccttt ccggatatcg gaggaacatc
     1561 ccttggtact tatccgtccg gatgtcacgg catacgactg gaatgaaatc agcgaagcac
     1621 tgtcttcact ggaatgtgtg gataccctgc tcacctgcaa aagccggcag aatgaactct
     1681 ctccttttgt ttccgaagaa acggataaag aacaatatac ccgcgcattc gggcgtttca
     1741 tcactccctt acaagagaag cagtttcaga aattggttct gtcacgttct tccgccagac
     1801 atatcggaga tgatttttca ccacttggcg cttttgtccg ggcctgtaac aattatccgc
     1861 gcatgatgat ttacctatgc cacacccccg cttccggaac ctggctgggc agcacaccgg
     1921 aaatcttatt aagcggacaa ggcaaagaat ggcacaccgt ggccctggct ggtacaatgc
     1981 cgatgcagga cgaagtgatg ccgacaaact gggacaagaa gaaccaagaa gaacagggct
     2041 atgtggctga ttatatccgc cggatcgcca aaaaattcgg caacaagatg acggagaaag
     2101 gtccctatac cgcccgtgcc ggacaattgg tacacctcaa gactgatttt tatttcttgt
     2161 tgaaaaatac agaccatata ggcgatttat tgcaagaact ccatcccact cccgccgtct
     2221 gcggcctgcc caaagaggag gctttccggt ttattctgaa caacgaaggg tacgaccgca
     2281 gttattattc cggattcacc ggatggctgg acacagaggg acataccgat atctacgtca
     2341 atctgcgctg catggaaata aagccgggtg aagccatcct gtatgcagga ggaggaatac
     2401 tggcttcctc ggaagtagaa tcggaatggg tggaaacggg agacaagatg aatacgatgc
     2461 ggagcatcct tcatcctgac tttataagta aacaaatgga aacaattaaa gtagaagaat
     2521 aatgtattca gacaaaaaga acatacttca gttggtggca cttctcaaag cgcacggtgt
     2581 gcggaaaata gtgctttgtc ccggcagccg taatgctgcc atcgtacaca ctctggccaa
     2641 tatagaggac ttcacttgtt attctgtaac cgatgaacgc agtgccggtt tttttgctat
     2701 cggcctatct ttacaagggg gaggtcctgc cgcagtatgc tgcacctccg gttcggccct
     2761 gctgaacctg caccctgcag tagccgaagc tttttaccaa caagtacctc tgattgtcat
     2821 ttctgccgac cgccccgccg cctggatagg acaaatggac ggacaaaccc tgccccagcc
     2881 ccatgtgttc ggaacgttag tcaagatgtc tgtcaacctg cccgaagtac atacagagga
     2941 agacgaatgg ttttgcaacc gcctcatcaa cgaagccata ctggaaacca cccaccacgg
     3001 caaaggaccc gtacatatca atgtacccat ttccgaaccc atctaccgct tcaccgccaa
     3061 aacacttccc gaggcacgtg tcatcacccg ttatcaggga ctgagcgtgt acgaccgtga
     3121 ctataaggaa ctgatcgaac ggctgaacaa gtacaacaag cgcatggtcg tggtaggcca
     3181 gatgaatctg atttacctgt tcgagaaaaa atatgtgaaa ccgctttata aacatttcgc
     3241 ctggttgacg gaacatctgg gcaaccagac catccccggc attcctatca agaatttcga
     3301 cgccgccgtt tattccatga cgccggagcg ccaggaagac atggcccccg aaatactgat
     3361 tacctacggc ggacatatcg tatccaagca attgaagaaa tacctgcgca atcatccccc
     3421 gcgcgaacat tggcatgttg ccgccgacgg gaagatagcc gatttatacg gttgcctgac
     3481 caccgtcatc gagatggatc cgtttgagtt cttggaaaaa atagctttcc tgctggacaa
     3541 caaaccgacc cattatccgc tgatgtggga aaactattgc aaaaccattc cgatgccgga
     3601 tcttgcttat tccgaaatct ccgttatcgg aaaactcatt caggcattac ccgaaccctg
     3661 tgccctgcat ctggcaaaca gctccaccgt gcgctatgca cagttattta cagttcctcc
     3721 ccgggtggaa atctgttgca accggggcgt gaacggcata gaaggctccc tgtccaccgc
     3781 catcggttat gccgccgctt ccagcaagct gaatttcatc atcataggcg acttgagctt
     3841 cttctatgat atgaacgcac tgtggaatca aaattacggt gccaacatcc gcatcctgtt
     3901 actgaataac gaaggaggag aaatattcca taccctgcct ggaatggata aatcaagccg
     3961 ttcccgggag tttatcacag ccgagcatta caccaccgcc aaaggctggg cggaagaacg
     4021 tggctttatt tacatgaaag tgaccggaga agaagagctg gaagaagcga tgcagccatt
     4081 cacctcaccc gagacaagga tgcaacccat gctgctggag gtgtttaccg acaaggaaaa
     4141 agacaccacc ctattaagag aatattatca cggacttaaa aataaaaatg aataatggaa
     4201 acaagaaaat ggaaaaccat caaagaatat caagatattc tgtttgactt ttacaacgga
     4261 atagcgaaaa tcaccatcaa ccgtccgcgt taccgcaatg cgttcacccc caccactact
     4321 tcggaaatca gcgacgccct gtattactgc cgcgagtgcc aggatatcaa tgtagtggtt
     4381 ctgaccggag caggtgacaa agccttctgc agcgggggag atatgcacgt aaaaggtcat
     4441 ggcggttata tcggcacaga tggagttccc cgtctgaatg tgctggacgt acaaaagcaa
     4501 atccggtcac tgccaaaacc ggtcatcgcc atggtaaacg gttacgccat cggcggcggc
     4561 catgtgctgc atgtggtatg cgatctgacc attgcctcag aaaatgccat tttcggacag
     4621 acaggtccca aggtaggcag cttcgacgcc ggattcggct cttcctatct ggcacgcatc
     4681 gtagggcaga agaaagcccg tgaaatatgg ttcctttgcc gtcaatactc cgcacaggaa
     4741 gcactggaaa tgggattagt caatacagtc gttcctttcg accgcctgga agacgaaacc
     4801 gtggcatggg cagaaaagat gatggagcac agcccgctcg ctcttcgtat gatcaaagcc
     4861 ggactgaatg ccgaactgga cggacaagcc ggcatacaag aacttgccgg agatgccacc
     4921 atgctgtatt acatgacaga ggaagcgcag gaaggaggga aggcattttt ggaaaaacgc
     4981 aagccacggt tccaggatta tccgaagttc ccataaacaa actacaaatt caaagcatgg
     5041 acattgaaga attcagaaaa tattgtcttt cgttaggtga cgtttccgaa aagatgccat
     5101 ttggcaaatt tgctgcaaga tatgattcca tccttgcctt ttatgtttat ggacacatgt
     5161 tctgttttat agacattgac aatttcactt ttgtcaatgt caaatctact tcggacgaaa
     5221 ttgagtatat aaaagagaga catgtttcag tcggcaatcc catcaaccaa agtctgaaac
     5281 attggcttca acttaatttt gatggtgata ttcccgacac gagcatatac acatgggtcc
     5341 aacgcgcctt tgagattgtc agggataaat ataccaaacc aactacacat aaaaaaaaat
     5401 gttccaaacc caaattataa aaaaacaatt acacttcaag caacctgccg gtacttccag
     5461 aggagtatat actacccggg atgtatggta catcctcctc accgacaccg gcagccgcca
     5521 ctatggcgtg ggtgaatgcg cccctctccc tgccctgagc tgtgatgata tcccctcata
     5581 cgacgaggtg ttggccactg cctgcaagaa cctggaaaag aacggggaaa tagaccggga
     5641 agccttgctt ccctatccgt ccatcctgtt cggtatggaa accgccctgc tgcatttccg
     5701 ggcacgcagc ctgcaattct ggcacacccc gttcagcaaa ggcaaagagg gtatccccat
     5761 caacggactc atctggatgg gaaactttga cgagatgtac cggcgcatcg gggaaaagat
     5821 gcagcaaggt ttccgctgca tcaaactcaa aataggcgct atcgactttg aaaaggaact
     5881 ggagctgctg gcgcacatcc gccggcattt caccccagcc caaatcgaac tgcgtgtaga
     5941 tgccaacggt gctttctctc ctaccgatac cctcgaaaag ttacatcgtc tttccgaatt
     6001 ccagctccat tccatcgaac agcccatccg tgcgggacaa tgggatgaaa tggcccgact
     6061 ctgtgccgcc accccctttc ccattgcact ggatgaagag ctgataggca tcaaccggcg
     6121 cgaccggaaa atagaattgc tggaaaccat ccgtcctcag tacattatcc tgaaaccttc
     6181 tctgcacgga ggaatcagcg gctccgaaga atggatggaa ctggcggctg aaagaggcat
     6241 cggctcatgg gtcacttccg ctctggagtc caatatcgga ctgaatgcca tcgcacaatg
     6301 gtgtgccacc ttgcagcccg ccctccccca aggactaggt accggcttgc tgtttaccga
     6361 caatatagac tatccgcttc acatcgaagg ggactgcctt tggttccacc ccgaagaaca
     6421 agaacccgat ttactaaact ggctgaaaca atgacaaaat tctgcaccaa tagaaacaaa
     6481 caaaccattc tgatagaaag catcccctac tccaattggg aaattgaaat ggtaagaatg
     6541 aatatccctg ccgacaaccg aagtttccgg caggaacttt tctcctttct ttccgaatgg
     6601 tttgacccgg cagacaccct gctggtacat acttcaggct ccactggcaa acccaaggaa
     6661 ctgtatgtag aaaaagaacg catgatggaa agcgcctgcc tcacctgttc cttcctcgga
     6721 ctacaaaaag aagattccgc cctgctctgt atgcccttgc aatacattgc cggaaaaatg
     6781 gtggtagtac gtgccttggt agcgggactg gacttgctgc ctgtcactcc atccgggcat
     6841 cctttaaaag acctgacaaa agcccccgtc tttgccgcca tgatccccat gcaagtctat
     6901 aactcactgc aagttcccga agagagagcg atattgcaac aaatcaggca cctcattatc
     6961 ggaggtggtc ctatcgactc ccaattgaac gctgcgttaa aagatttccc ccatgccgta
     7021 tggtctactt acggcatgac cgaaacctta tcacacattg ccctacgcag actgaacggt
     7081 cctgaagctt cagactggta cacccctttc gagagcatac agatccgtct gagtaaagaa
     7141 aacaccttgg tgatatacgc tcccgaaatt tgcggaaaag aactggtgac caatgacata
     7201 gccgagataa acggacagaa ccaattccgc attctaggca gaaaagacaa tacgatcaat
     7261 accggaggag tgaaagtgca gatagaacaa gtagaggccg cattgaaaga acacctgtcc
     7321 gttcctttct tgatcacctc cgctcccgac gaaaaattcg gagaaatcat tgtgctgctt
     7381 gccgaagggc aactgcccga cgacatagaa cagacctgca cacatcaatt acctccctac
     7441 tggcgtccca aacgttttgt tccggtattc aaacttcccc tgacagaaac cgggaaaccc
     7501 gaccgtgcca tagccaaatt actggcgcaa aaataactcc gctccattca taaagggtga
     7561 attcaaaaac aaatcaaacg atctttttga attcaccctt ctttctgtaa aaaagaataa
     7621 ttttccgtgt tctcctacaa cttacgggaa gctaaaattg ttctcctatc attatattaa
     7681 aaaaatcaaa tacatgtagt ttttttccgt tttattttcc cttatgtcca ctacttccgg
     7741 cggaatgtat cattaaattc taattttgtg aacctagagc tgatacaaag tatgttatat
     7801 aataccccaa aaccacagga taccaaagaa ggactgtccg atcaagattt cagtatttat
     7861 atggatgcgc acacagtgcc tttcagcaaa tacccctctt atctgccgga aggagttttg
     7921 ggtatgtgta ctgaagggaa tgccgagatc cagattggtc tccggaaata tgttatttgt
     7981 gcaaacgaca ttcttatttt catgccggga ttcttggttt catttataaa atccagtctg
     8041 actttcacca tcgattattg tactttttca aatgcccttt tttatgacgt gatcaatgga
     8101 agtatcaaac gttttccgac cggttttcat acctacaccc aaacccactg catctattcg
     8161 ctatcccaag agaaagcgga acagttctcc ctctatttcc ggttactata caacagagct
     8221 acttctccaa cttatttatt tacaaaagaa tctattacca atctgctgaa attacctttt
     8281 ctggaacttt atgcagacta ttacagcaca gtaaaagaac ataaagtcac caccttgcat
     8341 aaagaagaaa tcggatactt ttttctggat ttgctgttaa agcattacaa agaaaacaaa
     8401 gaagtggcgt tctatgccga aaagttgcat gtttcctcca aatacctgac tgaagccttg
     8461 actctggtaa gtggaaaatc ccccaaagaa tggattatac attataccct gcaagagatt
     8521 tacgcattat tggagaatcc atccatcagc atacaggaaa tcgttcaaag aacccggttt
     8581 gccaatcttg ccaccttaag acgtttcttc aagcggcata ccggaacatc cctgttgcaa
     8641 taccggaaac aggacttata caaaaataat caacaatagg tatctcaata aaaaaatcag
     8701 cccgtcccaa gcattcttcc ggaacgggct gatccctcta tctaccaaaa cttgttgttt
     8761 tccttactat actcaaatcc ggccgccttc aattttttca ccaacagctc cttgtctaca
     8821 tccatatcat cacaaagctc gtccagcgaa tgatagcagt cacgaagttt catattcacc
     8881 atgctgaaaa gcatcatcgg gtcatcaggt aattccatat caatatctcc ttttttaaaa
     8941 tcggatgcaa agttacaaaa cttttcataa tgatccgtat tccatcgcta aatatcggtc
     9001 tgacaaaaag ttatcccctg ctttttatcc tattaatccg tcagcttcac cgtttccatc
     9061 ttccccggaa ccaaagtaag acgcgccgtt ccatccctgt ctatctccac ctccatatac
     9121 cgggcccgga taatgatcct tccgtctaca gtcagcaccc cccactggca ggagctgtcc
     9181 tgataggcgc aataaccacc caccggacgc aatattctcc gatagacagg tggaatcaaa
     9241 atctgctccg ctgtcctcag cccccatttc actcctatct gaaaaggtac ggcctccaca
     9301 ctcctgctga ttatacgctg ccgtttccgt tcagtctcgc acttttcctc ctgcaaatgt
     9361 ttctccacac gctcgtccgc ctgccttcgg agcaatgcca ccgcctcatc aaaatcctca
     9421 ctccggtccg acggacggtt acaagccaca taacgctttc catgtccttt ctccacatga
     9481 taataccgtc cctcctcatc catcaccaca atactttgat ccggcaaccg tccgctcaga
     9541 taataagcac gctcctcatc cccttccaac agacaaacct gcggttcaca acaaaagcct
     9601 ccatcttcca tgcggcggca tcgggaaggc actctgccat cgtacatctt cacataaaac
     9661 cccatccaca caatggacga agaaggcaac ccgcatgtat tggcatacac ctgccttgtc
     9721 ctgctgtaat aagtacggtt cacctgtaac aattctatgc tcccgtatct gaggacacgc
     9781 gggcggacag cataacaccg gccgttccgt aaatccacat aagacaccga attcccgaca
     9841 tgacggactt gcaacaaatc atctttcagc aacctcacct cacagcaatg ccccagttcg
     9901 gccaccaaag cccccgtatc atccagtacc cggacacacc cgttccgaag cctccccacg
     9961 gcaaaacgtc ctttgatact caaaacctct ttaaacgaag cgtccggcag catctcatct
    10021 cccttttcca atccccaaag acctgtttcc ttatctacaa atgccctcag cctgcatgac
    10081 ggtgactgct ccttctcatc cggcaaagcc tgctctctga tggaagaaag caaacgcccg
    10141 tgctccataa ccaccaccaa gtccccaccg gcttcagccg gcctttccac caccggaaaa
    10201 gcagtaacgg aagcatcaca attcatccgt ccgggcaaac tcccctttcc cgccatccgt
    10261 ccccggaaca tagcatccca gttccatcgc tgtgtaggaa gcccgaaaat gcggtacagc
    10321 cccacattgt ctatcagcat acacgcctcc ttgccctccg atctccgcaa tccgcgtcct
    10381 acctgctgca aatatttagc cagtgacaaa gtaggacggg ccagttgtac aaactccaca
    10441 tcgggacagt cgaacccctc gctaaataca tccacattca ccagcacctc gatttttcca
    10501 tgtctgaact cctccaccat ccgcttgcgt tccatagcag gagtcttgct gtccacagcc
    10561 accgcattca ctccccgcct gctgtaatac tccgctatcc gccgggcatg ttcaatgctg
    10621 atggcataca ccatcccctt cttgccggaa gcaaactgcc tgacactgcg gtacaggcgc
    10681 tcgataccgg gacgcctgtt cagtaccgca tccatctctt tcacctgata atccccatcg
    10741 accccccgtt tctccagacc gtcaatgagc cgctgctcct cgctgccggg acggatggat
    10801 acataatcga acacagacaa cacgcctttt tcaataaact cggcaatact ccacgaagta
    10861 accagcacct cgaacagttc cgtgaacccc ctacggttca ggcggcaagg tgtggcagtc
    10921 acacccagtt tctttgcggc aggataacgc ttccacatct ccgtgtaaga agcggctaag
    10981 gcatgatgag cctcgtctat cacaatcagt cccggagcat cacccgcctc attccagtgc
    11041 cgggatagcc attggacaga cattaccctg accggagtat cctccctccg gataccatat
    11101 ttagccagag tttcctccat ttgctccacc agttccctac gatgggcaat aagccatacc
    11161 ccactgcctg cagaagacac aaactcactg accacagatg ccagcagatg tgtcttgccc
    11221 gtaccggtag gcatctgcac catcacactc cggtgagctt tccacgcttc catcagacgt
    11281 gttttcatct ctatctgata atcccgcaac ataaataatt tgccgatttg ctaacgtgcc
    11341 aatggagtaa gaggataatc gaaaaaatta tttactagcc agcatattat taatctgcgc
    11401 ccgtatattg gctatcgtac cgcccgacac gagccgtttg gcaaaaggta gcaacgactt
    11461 gataaaagcc gctttcacca ccgtgtgttt gtctacattc ctacagttct catcgaccag
    11521 catctttcct accaccaccg ccagttcgcg tgccgtggta cactctccca aaagtatctt
    11581 gtaagccctc atcaccttta tatcgggtat atagaccgat acgtaaaatt catcatccga
    11641 cagttccgcc ggttcctgtg ccggcttctc atccgccaca ctttctgtat tctccgtttt
    11701 ctcagaatct tccggttggt cggcgacctc atcaccccgg tcgccataaa agttctgaat
    11761 ggcggaagat gccacaggag caatcagatt atttccgcca taaatattta tcatcatatc
    11821 aggtttttca ttcatatact atttcttttc tctattcttt aattattatc aacagatcgt
    11881 taatcaaaat ccatatttca tcaatatata atcaatagca tgcaccaata gtaaacagat
    11941 agtaaacggt tatgaatcga tttccatacg tcattcccta cccgtatatt tgtgcagata
    12001 aatcaaaatc aatttctttt atgaaagaat acatcatgtc atttttcaat gcacccgtca
    12061 ccaataaaat acccacatgt atatgcagtg tggcagggct tcatacctac atcagcacca
    12121 atccgcaact ggaagaactg acgcgtaaag tcagagccgg actcggagac aagcaagcgt
    12181 tccgaaagaa taaacagacc cttttaccgt atgtcactcc ggcaggtatc ttctcttact
    12241 gcaaagagca atgcatgcaa gttccttcgg gcctctttgt catagatatt gacgaactgg
    12301 cttccaccga agaagcggca atgtggcgcg accgtctctt tgccgatgaa gtgctgcacc
    12361 ccgtactttc ctttgtcagc cccggaaatc agggagtaaa actttttatc ccttatcgca
    12421 taaacccttt cctgagcgta gaagaatcct tcgacaatgc cctgcacacc gcatgggagt
    12481 atctggaatg gaaatacgag ctgaaagtgg acagggccaa tgccgacttg tccagagcct
    12541 gttttctgtc gcacgacgga gaagcgaaaa tcaataacca taaatattaa aaaatgaacg
    12601 attctatttc tatcttggaa cagctggtaa cagccatcga acaagcggga gtcaatgtgg
    12661 cccccaccta tcaggaatat atgccgctgg cctttgccat agccaactgt tgcggagaag
    12721 aaggacgcac ccggttccac cgcatctgcc gcatatccga aaagtaccac cacgatgaag
    12781 cagacaaact gtacggacat gctctgacca aaggaacagg cagaaattcc ctgggaaccg
    12841 tcttccatct ggcagaggtg gccggggtga aaatggaccc gaaacttgca aacttgcaga
    12901 acttgcagtc tctccacacc cacacacgtg cacgcgtatc ctataatgcc catccggatg
    12961 cctccgacgg gactccgccc gacgctgttt tcacggacac agcctccccc ctgtccgacg
    13021 gcgtgcccaa agccatcctc cctgcccgac ttccctcttt ccccgactac cgctggcccg
    13081 ccttcctgca agggatcata gactgcggta actctcccgc ccaacgggat atcctgctgc
    13141 tgggtgcagc aaccgtgctg ggaagcaccc tcaacaaact ggtaagtttt gtgtacggac
    13201 gaaaacacaa gtatccctgt ctgcaagtgt tcgtcaccgc gcctcccgct tccggcaagg
    13261 gtgcactgac ctgggtacgc cgtctggcag aacccataca caacgcgctg ctggacacct
    13321 accgggaaaa aataaagacc taccgcatgg aaaagaccaa atgggacact ttggggaagg
    13381 aaaaggtaaa tacccctgaa cccgaacagc cccagctgaa aatgctcctc atagccggtg
    13441 acaataccgg tacaggcata caggaaaacc tgatggactc cggaggcgta ggactgatat
    13501 gcgaaaccga ggccgacacc gtgagcaccg ccattggagg cgatcacgga cactggagcg
    13561 acctcctccg gaaatgtttc gaccatgacc ggctggccta caaccggcgc accaatcacg
    13621 aataccgcga atgtaacgtc acgttcctct gcgtgcttct cagcggcacg cctgcacaaa
    13681 tcaagcccct tatcccatcg gccgaaaacg gattgttctc gcgccagctg ttctactata
    13741 tgcctgccat tgaagaatgg gaagaccagt tcaacgaagc ggatacagac tatgactccc
    13801 gttttctgga atggggggca caatggaaag aagtgctgaa cgccatcacc gcctcggtga
    13861 gcaacatcaa catgaagctc acccacgagc aaaaagagat attcaacttc cactttgccc
    13921 gtgtattcgg acgagcctcc gccattcacg gtaaccagat gaaaagcgct gtaacccgta
    13981 ttgccatcaa tatcttccgc atcataagca ttatcgccct gctgcgctct ctggaatccc
    14041 tgctgccggg aggcgaaagg agtggcgaac cacaggaaaa catcgtgcgt accctgctga
    14101 actgtcccgg actgaccccg tcggcccata ttccacaaga aaacatagca gacggaatcg
    14161 tgccgcaatt caacctctcc atccgcaccg acgactttta tgccgtgctg gccttggtgg
    14221 aacctctgta ccgccatgca tgccacattc tctcgctcct gcccgcagga ccccccagcg
    14281 caccatcggc gaacatgact cccgaaaccc tgttcgactg ccttcccctg cgcttcaccc
    14341 gcaacgaagc catcgacaaa ggagaacagg taggagttcc ggcaggctcg gtggactcgc
    14401 tgctgaaacg tatgaccgaa cgcggacagc tggtcaaagt ggggcgtggc gaatacgaat
    14461 tcaacgcgcg catgcacaca cgtacgtgtg tgggtgtgag agagagtgca agttctgcaa
    14521 gtttgcaaga ttcctgaatt taaaatgtat aaatatgaaa gattttcttt atttcccatc
    14581 catgacaaag ggtagcctgg ctctgctcta ttttcccggt tcaaatcccc ggatagccac
    14641 ccggcatctg atgaggtgga taaacggctg tccccctctg atggaagagt tatccgcaac
    14701 gggttactat acctcgcaaa aagtcttcac gagccgccag gtgacactga tcaaccggca
    14761 tctgggcagc cccggatagc cctgcaagct ctttggaaca ggatgaaagc cataaagtgc
    14821 cacaaggtgt cataaagcgt cagcacgcat ttcacagtac ctatctttgc aatgtcaaca
    14881 atgagggagc cgatacgtta ctaaccttcg gcctagcatg ttactaacat gtaaccccat
    14941 acgttactaa ccttcagcct tacacgttac ctacgtgcaa tccgcaagaa aagtaaagta
    15001 ttctccttct tcactg
//
