LOCUS       gnlProkkaNHICBGCI_29   13973 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NHICBGCI_29.
ACCESSION   gnlProkkaNHICBGCI_29
VERSION     gnlProkkaNHICBGCI_29
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 17:57:06
            Original ID  :: gnl|Prokka|NHICBGCI_29
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 562305
            Orig. end    :: 576278
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13973
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[5000:12785]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..12785
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..13973
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13973
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(250..1122)
                     /locus_tag="ctg29_499"
                     /transl_table=11
                     /translation="MVIAKLFGGLGNQMFIYAAAKGIAQISNQKLTFDIYTGFEDDSRF
                     RRVYELKQFNLSVQESRRWMSFRYPLGRILRKISRKIGFCIPLVNFKFIVEKKPYHFQN
                     EIMRIASFSSIYLEGYFQSYKYFSKIEAQIREDFKFTKEVIGSVEKEASFITNSRYTPV
                     AIGVRRYSEMKGEFGELAVVEHDYYDAAIKYIANKVPNLIFIVFSEDIDWVKKNLKLDY
                     PVYFVTSKKGELAAIQDMYLMSLCNHHIISNSSFYWWGAYLASTNNHIVIAPSVFLNKD
                     CTPIDWVII"
     CDS             complement(1109..2365)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg29_500"
                     /sec_met_domain="Polysacc_synt (E-value: 1.1e-11, bitscore:
                     39.6, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSRFIELITVTASSIIELSTTLLITKIVAVQLSKDGYGFYSLIL
                     SVVALFSLLPFSSLHVGIERYIIEYKNRNKFARFYASIYLIHIVFFVLYLLLLLPLSPF
                     LTGEWNEIWEIVYLFFITKVYKQFVFCILNINRKRISILYARIIDLSIQLILLYFFLIK
                     GLSIQEILYASIVSSLLTIGYLVYIDSHNIYLKKVRVSDFLLVLKDVFSYSYPLIIWGI
                     FAWIQSMIGRWFVDFYLTKSDVANFSMIFSLSLLPSTAISAIIGSYFVPIAYSNEAKST
                     GFIGRYINKILFAVSLVWLVIILTFLFLGEYIIVLFLDVKYLNIYWYLFWGLLGTGVYT
                     LGQLSVYELYYYKKVKYLLLPNLLPGLLTIVGCMIIVPFWGFDGAVYVNVFTYVISGIL
                     TLYCTLYYGRKIKIIYGNC"
     CDS             complement(2362..3528)
                     /locus_tag="ctg29_501"
                     /transl_table=11
                     /translation="MKVLLVFIDMMRTDLLSVYNQNVKDKTSFDLLLEKIGGCIYTNCY
                     TPAPDTPRSLACLQTGLHPYFNGCNTRIKWPKYYVKEEIDTIFDILSNNKILINYYAPK
                     VDLDTGALSIKEGSVVNLFTNIEKFTSNILQSTCDEMDFLTLDDYHWAIDDYGATHKAV
                     KIGHNIISNVLNTFFRTHSYDEFDHIFFFSDHGHKLENEIALMESALELLRDDRAKILM
                     VHRSKRNSGLSIDNRLCSIQDLYATILSIFHLNYDHRDSLSLLSTSKSDVHDHLIIEDH
                     ADFTVSLNQVISVWRYISDAGSFYTNVCKYSKEGYCELSNSTIISLIQQKSPTYLDYER
                     QMLILKEYSKMSEKYCTYSNGGKRLGRKKQVLLKVKNKCYRFLIKCFR"
     CDS             complement(3525..4469)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg29_502"
                     /sec_met_domain="Glycos_transf_2 (E-value: 2.8e-20,
                     bitscore: 67.8, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGKNNRIPLVSVCCMTYNHDKFISQCLDGIIQQKGNFSIEILIHD
                     DASSDHTRQIIEFYRDKYPDIIKPLYQEINQYSRGVNIWNTYMFPLVKGEYIAICDGDD
                     YWIDQYKLEKQITFLQKYADYNLVYTNKIVINELGTRVIRNHPKYLSGNLFVNLLSGGN
                     PITTSTVCIRTHDAFEIMDIVNSIPFRTVMGDLQLWLALAIKGKFKYLAFKSTVYRLSS
                     ISLSHSLSVNREIRFSKHEYFIKKYFADIFQVNIDKKILERTYYKNTIRRLFSFRKEIF
                     LSYVFKSVKKDPFLIFDIKIITLVGVKLLKSIL"
     CDS             complement(4456..5004)
                     /locus_tag="ctg29_503"
                     /transl_table=11
                     /translation="MTSFYSEKELANIGLAVYGTNVLISRKVSFYSPKNIYIGNNVRID
                     DFCILSGKILIGSNIHISAYVAIYGGYGVVLEDYVGISPRTTIYSAMDDFSGDYLVGPI
                     HDKRLTHVIGGEVRICKFAHIGANTIVYPGCSIGEGTVVGAMSMVRKSLDAWGVYIGIP
                     AKFLKNRNKNMQSLIYGKE"
     CDS             complement(5001..6110)
                     /NRPS_PKS="Domain: Aminotran_1_2 (37-163). E-value:
                     1.2e-06. Score: 19.8. Matches aSDomain:
                     nrpspksdomains_ctg29_504_Aminotran_1_2.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056:DegT/DnrJ/EryC1/StrS aminotransferase (Score:
                     280.3; E-value: 4.2e-85)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg29_504"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 6.2e-94,
                     bitscore: 310.1, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.1e-05, bitscore:
                     19.8, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEENQITVTSPLLPSLDDFLPYLEDIWKRKWITNNGYYHQELEKA
                     LCQYLKVPYISLFTNGTLPLICSLQALRITGEVITTPYSFVATTHALWWNGIKPVFVDI
                     DPKTCNIDPNKIEAAITPKTTAIMPVHVYGNPCDFIAIQDIADKYGLKVIYDAAHAFGV
                     EVDGKSLLEFGDMSTLSFHATKVYNTIEGGALVCHDRQIKERVDFLKNFGFAGETQIVA
                     PGINGKIDEIRSAYGLLNLKAVDSAIEYRHQISKRYREGLGGIDGISYMPEMHNIRHNY
                     SYFPIFIDSVKYGITRDELYEKMKRNGVCGRRYFYPLITNFSTYCGLDSAQISNLPVAN
                     RIANSVICLPLHTGLTSIDVERIIELLKK"
     aSDomain        complement(5622..5999)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg29_504_Aminotran_1_2.1"
                     /evalue="1.20E-06"
                     /label="ctg29_504_Aminotran_1_2.1"
                     /locus_tag="ctg29_504"
                     /protein_end="163"
                     /protein_start="37"
                     /score="19.8"
                     /tool="antismash"
                     /translation="YHQELEKALCQYLKVPYISLFTNGTLPLICSLQALRITGEVITTP
                     YSFVATTHALWWNGIKPVFVDIDPKTCNIDPNKIEAAITPKTTAIMPVHVYGNPCDFIA
                     IQDIADKYGLKVIYDAAHAFGV"
     CDS             complement(6113..7237)
                     /NRPS_PKS="Domain: Aminotran_5 (30-301). E-value: 6.1e-34.
                     Score: 109.3. Matches aSDomain:
                     nrpspksdomains_ctg29_505_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 80.4; E-value:
                     2e-24)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg29_505"
                     /sec_met_domain="Aminotran_5 (E-value: 3.9e-30, bitscore:
                     100.0, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIERKILLNPGPATTTDTVKLAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGDLSKHTAVLFCGSGTINIDICLNSLLPADKKVLVVNNGAYSTRAVEVCEYY
                     GLPHIDLKFSVYELPDLSVIEKTLSDNPDIALVYTTHHETGTGILNPIREIGKIAHSHG
                     AVFVVDTTSSLGMIPFDIGKDNVDFCMASAQKGLQAMTGLSFIIGDESLIRASRDYPKR
                     SYYCNLYLQYDYFEKTGEMHFTPPVQTVYAARQALDEYFAVGEEAKFARHKRVFEAIHK
                     GLQELGLQYAIKREWQSGLVVSVLYPDDPLWDFDKVHDYCYERGFTIYPGKISTTNTFR
                     LCALGEIDVEDIERFFEVMREAISFLKISFKNIV"
     aSDomain        complement(6335..7147)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg29_505_Aminotran_5.1"
                     /evalue="6.10E-34"
                     /label="ctg29_505_Aminotran_5.1"
                     /locus_tag="ctg29_505"
                     /protein_end="301"
                     /protein_start="30"
                     /score="109.3"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGDLSKHTAVLFCGSGTINIDICL
                     NSLLPADKKVLVVNNGAYSTRAVEVCEYYGLPHIDLKFSVYELPDLSVIEKTLSDNPDI
                     ALVYTTHHETGTGILNPIREIGKIAHSHGAVFVVDTTSSLGMIPFDIGKDNVDFCMASA
                     QKGLQAMTGLSFIIGDESLIRASRDYPKRSYYCNLYLQYDYFEKTGEMHFTPPVQTVYA
                     ARQALDEYFAVGEEAKFARHKRVFEAIHKGLQELGLQYAIKREWQSGLV"
     CDS             complement(7234..8370)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 71.8;
                     E-value: 7.9e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg29_506"
                     /sec_met_domain="TPP_enzyme_N (E-value: 7.7e-21, bitscore:
                     69.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.1e-19, bitscore:
                     64.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSVEKIYDTFLHHGVDFFTGVPDSLLKNICAYITDHAPRGKHII
                     AANEGSAVGIACGYYMASGNVPLVYMQNSGLGNTVNPLLSLADEKVYSLPLLLLVGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMKIPFIILDTDEDEALAQIHDAVVSAKSRSIPHAIV
                     IRKDTFGKYKLRQEALNDYPLSREEALMQVVDHLGDNDIVVSTTGKLSRELFEYRESKG
                     QGHARDFLTVGSMGHSSSIALGVALEKPDRRVYCLDGDGAFIMHMGAVSNIGDLSPKNY
                     RHVLFNNGAHESVGGQPTLGFRLDIASIAKGCGYAHVLTASDKEGLSCALEKLSGLSGP
                     VLLEIKVRIDSRDDLGRPTTTPVENKEHFMAFLKDTHS"
     CDS             complement(8382..9683)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 214.1;
                     E-value: 3.9e-65)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg29_507"
                     /sec_met_domain="CTP_transf_like (E-value: 1.3e-11,
                     bitscore: 39.9, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 4.7e-121, bitscore:
                     398.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 2.4e-63, bitscore:
                     208.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKIYVGMTADIMHPGLIHIIHEATKYGDVIVGLLTDKAIAEHK
                     RLPYLTYDQRKEVVENIKGVCEVVPQEDWSYVPNLEKLKPDYIIHGDDWKTGPLREVRE
                     QVFEVMNAQGGKVIEIPYTRGINSSSLDKDIKAIGTTPDVRLKSLRRLIQAKPVVRILE
                     AHDGLCGLIIENLEVQKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAVIIEDKVGLKKNSLFGTDAIQTQDS
                     IEGFCDKIRAGKNAQVTGDFMIIARIESLIAGKPMSDALERAYAYVQAGADGIMIHSKD
                     KSGEDIREFCRTFRKEYAHVPIVVVPTTYDHVHESELHEWGANVVIYANHLLRAAYPAM
                     MNVARTILENERAEEVRPLCMPIKEILELIPGTK"
     CDS             complement(9703..10401)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg29_508"
                     /sec_met_domain="NTP_transf_3 (E-value: 5.6e-13, bitscore:
                     44.5, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAGLGTRFGHYTELVPKGFVEVGGKPMIIRSIETLLSCGIERII
                     LGTGYKKEAYEALQADFPQIETCFSPRYADTNSMYTLYNTRDVIGDDSFLLLESDLVFE
                     RKALLSLLDDEFPDVMLVSSLTKFQDQYYVEYDRNHILTSCSVDKDALEAKGELVGIHK
                     LSNTFYRRMCADYATILESQPKLGYEYELLRMSRSVSPVRVLRVEGLKWYEIDDEADLS
                     YAEEHIIRYC"
     CDS             complement(10415..11719)
                     /locus_tag="ctg29_509"
                     /transl_table=11
                     /translation="MIYMFTRMIRSLLSRSPLYVLALYASVLIFLVYTCAYAYRKPFTA
                     AIYEGEILWGFDVKILYVLSEIIGYALSKFIGVRILPSMKAGHRIYYIIGLLTFSEVAL
                     LGFALLPVPLKVCSIFLSGLPLGMIWGVIFSYIEGRRISEILNVGLSVALIVSSGLVKT
                     LGQFVMDNLHVSEYWMPFTTGLLVYPVMLLCSWLLNQIPAPNEQDIIQRTKRAPMDGKD
                     RRKFLRQFFWGICMLVVFYGALTVFRELRDSFAADIWKELHIEGAMIFTQTEVPIAVFV
                     LVLMFLIVFVRNNRLALNIIYCIAVTGGSLMVFSTLLYVYGFLSPIWWMILSGLGLYMG
                     YIPFTYLIERLIASLRVVSTAVFIIYLADSFGYLGTTGVFMVKNFVSADISWTVMLMRT
                     ALFSGFVSVLSIFAIYCYFKQQLNSLILIPSEIHD"
     CDS             complement(11892..12785)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 268.8; E-value:
                     9.4e-82)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg29_510"
                     /sec_met_domain="NTP_transf_3 (E-value: 4.6e-12, bitscore:
                     41.5, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKGIVLAGGSGTRLYPITKGVSKQLLPIFDKPMIYYPISVLMLAG
                     IREILIISTPYDLPGFQRLLGDGSDFGVHFEYAEQPSPDGLAQAFIIGEKFIGSDSVCL
                     VLGDNIFYGQGFTRMLREAVHSAESENKATVFGYWVSDPERYGVAEFDQEGNVLSIEEK
                     PQIPKSHYAVVGLYFYPNKVVEIAQNIKPSPRGELEITTVNQQFLLDQELKVKLLGRGF
                     AWLDTGTHDSLSEASTFIEVIEKRQGLKVACLEGIAFRQGWISSEKMKVLAQPMLKSQY
                     GQYMLKMIDITTSNEE"
     CDS             complement(12817..13299)
                     /locus_tag="ctg29_511"
                     /transl_table=11
                     /translation="MNTLTSQIEQLQSLAHELLYLGVDGAPIYTDHFRQLNKEVLEQSD
                     ALYPQRGATPEEEANICLALLMGYNATIYNQGDKEEKKQVVLNRCWDVLDQLPATLLKC
                     QLLTYCYGEVFEEELAKEAHTIIESWKDKELSEDKKEAINNLRNLEENPYPYSEME"
     CDS             complement(13303..13827)
                     /locus_tag="ctg29_512"
                     /transl_table=11
                     /translation="MSEQQKYWFAARTRDKQEFAIRDSLEKLKTELDLNYYLPTQFVIR
                     QLKYRRKRVEVPVIKNLIFIQATKQDACDISNKYNIQLFYMKDLLTRAMLIVPDKQMQD
                     FIFVMDLDPNGVSFDNDHLSVGSRVQVVKGDFCGVEGELASEANKTYVVIRIAGVLSAS
                     VKVPKSYLRVI"
ORIGIN
        1 aagatgtagc tctctattaa ctctttccca aaaaacacaa actaatcata aatagaactc
       61 acagttacaa atcgtaatta cattttatct taaattgagg tgacaaaaga aagaatggat
      121 aatgtgaaat ttaagataaa taaaaaacat aaaaattaat tcttgtcaaa tagaacaaac
      181 aacaaaatca atcaaaaaaa ttaaaagtgc agtggttcta ttaataaaag acaagtaaat
      241 agcttacaat taaataatca cccaatctat aggagtgcag tctttattta agaaaacaga
      301 tggagctata acaatgtgat tgtttgtaga agccaaatat gcaccccacc aataaaaact
      361 actattcgaa attatatgat gattacataa agacattaaa tacatatctt gaatagctgc
      421 taactctccc tttttagaag taacaaaata cactggataa tctaacttca aatttttttt
      481 tacccaatca atatcttcag aaaaaacaat aaaaattaaa ttaggaactt tatttgctat
      541 atattttatg gccgcatcat aataatcatg ttccaccaca gctaattcac caaattcccc
      601 tttcatctcg gaataacggc gtacgcctat agccaccggt gtatatcgtg agttggttat
      661 aaaagaagcc tctttctcaa ctgaaccaat aacttcttta gtaaatttaa aatcttctct
      721 tatttgtgct tctatttttg agaagtattt atatgattga aaataccctt ctaagtaaat
      781 tgaagaaaag gaagctatcc tcattatttc attttgaaaa tgatatggct tcttttcaac
      841 tataaattta aaattaacca aaggaataca aaatccgatt tttcggctaa tttttctcag
      901 tattctccct agcggatatc gaaaagacat ccacctccta gattcctgta cagacaaatt
      961 aaattgtttt aattcataaa ctctccgaaa cctagaatca tcttcaaagc cggtataaat
     1021 atcaaatgtt aatttttggt ttgaaatttg tgcaatacct tttgcagctg cataaataaa
     1081 catttgattt cctaatcctc caaataattt agcaattacc ataaattatt ttaattttac
     1141 gaccataata taaagtacaa tataaagtta aaatccctga tattacataa gtaaatacat
     1201 tcacatatac agctccatca aatccccaaa aaggaacaat aatcatacat ccaacaattg
     1261 tcaaaaggcc cggtagtaga ttaggtagca acaagtattt cactttttta taatagtata
     1321 attcatacac agacaactgt cctaatgtat agacgccagt ccctaataac ccccaaaaca
     1381 agtaccaata tatatttaaa tattttacgt ctaaaaaaag tacaataata tattcaccca
     1441 aaaataagaa agtcaatata atcacaagcc acacaagtga aacagcaaat agaattttat
     1501 tgatatacct accaataaac ccagtagatt tcgcttcatt tgaatatgct attggaacaa
     1561 aataactacc aataatagca cttattgcag tagatggcaa cagagataat gaaaatatca
     1621 tactgaagtt agcaacatca gattttgtta aataaaaatc aacaaaccac cgtccaatca
     1681 ttgattgaat ccaagcaaaa attccccata taattaaagg atatgaatag ctaaacacat
     1741 ctttcaatac caataaaaaa tcactaactc taaccttttt taaatagata ttatgcgaat
     1801 caatataaac tagatatcca atagttagta aactactcac tattgaagca tataatattt
     1861 cttgaataga caaccctttt ataagaaaaa aatacaataa tataagttga atacttaaat
     1921 caattattct cgcatataat atagaaattc ttttacgatt aatattcaaa atgcagaaaa
     1981 caaactgttt ataaactttt gtaataaaga ataaatatac aatctcccaa atctcattcc
     2041 attcccctgt taaaaaggga cttagaggca acaaaagcaa caaatataag acaaaaaaga
     2101 caatatgaat taaatatatt gaagcataaa atctagcaaa cttgttccta tttttatatt
     2161 ctataatata acgttcaatg ccaacatgca atgacgaaaa tggtaataaa gagaaaagag
     2221 ccactacaga taatatgaga gagtaaaatc catatccgtc cttagataat tgaactgcaa
     2281 caattttagt tattaaaaga gtcgtagata attctataat gctacttgct gttacagtta
     2341 ttaattctat aaatcgactt ctcatctaaa acattttatc aagaatctat aacatttatt
     2401 tttaaccttt agtagaactt gtttttttct tcctaaacgt ttacccccat ttgaataggt
     2461 acaatatttc tctgacattt tagaatattc tttcaatatc aacatctgcc tttcataatc
     2521 taaataagta ggtgattttt gttgaattaa tgatataatt gtagaattgg aaagttcaca
     2581 gtatccctct ttactatatt tacaaacatt ggtataaaat gaacctgcat ccgaaatata
     2641 tctccaaaca cttataacct gattcaacga aacagtaaaa tctgcatgat cctctattat
     2701 tagatgatca tgtacatctg attttgaagt agacaataaa gataacgaat ctctatgatc
     2761 ataattcaaa tgaaaaatgg atagaatagt agcatataaa tcttgtattg aacataatct
     2821 attgtcaata gacaaaccac tatttctttt cgaacggtgt accattaaga ttttagctct
     2881 atcgtctctc aaaagttcta aagcactttc cataagagct atctcatttt ccaatttatg
     2941 tccatgatct gaaaagaaaa aaatgtgatc gaactcatca taagaatgcg ttctaaagaa
     3001 ggtattcaat acatttgaaa taatattatg gcctattttc acagctttat gggtagcgcc
     3061 ataatcatct atggcccaat gataatcatc taatgttaaa aagtccattt catcgcaagt
     3121 actctgcaaa atatttgaag taaacttttc aatattagta aatagattca ctacacttcc
     3181 ttcttttata gataacgctc ctgtatcaag atcaacttta ggagcataat aattaataag
     3241 aattttatta ttagaaagaa tatcaaaaat agtatctatt tcctctttga cataatattt
     3301 aggccattta attcttgtat tacatccatt gaaatatgga tgcaatccag tttgaagaca
     3361 agctaaacta cgtggagtat caggagctgg tgtatagcaa ttagtatata tacatccacc
     3421 aattttttct aacaataaat caaaacttgt tttatctttt acattttgat tatatacaga
     3481 tagtaaatct gttctcatca tatctataaa taccaataaa actttcataa aatggatttt
     3541 aataatttca cccccactaa tgttattatc tttatatcaa aaatcaagaa tggatctttt
     3601 ttcacagact taaaaacgta actcaaaaaa atttcttttc taaatgaaaa taatcgacga
     3661 attgtattct tataatatgt tcgttccaat atctttttat caatatttac ctgaaatata
     3721 tctgcaaaat attttttaat aaaatattca tgttttgaaa atcttatttc ccgatttaca
     3781 ctcaaagaat ggctaagaga aatagaggat aatctataga cagtagattt aaaagccaaa
     3841 tatttaaact ttccttttat ggctaaagct aaccataatt gtaaatctcc cattacagtt
     3901 ctaaatggaa tagaatttac aatatccatt atttcaaatg catcatgagt tcgaatacat
     3961 acagtagatg ttgtaatagg attacctcca cttaacaaat tcacaaacaa atttcccgat
     4021 aaatatttag gatgattcct aattactctg gttcctaatt cgtttataac aattttattt
     4081 gtataaacca aattatagtc agcatatttt tgcaagaaag ttatttgttt ctccaattta
     4141 tattgatcta tccaatagtc atccccatca catatagcaa tatattctcc tttaaccaat
     4201 ggaaacatat aagtgttcca tatattaacc ccccgagaat attgattaat ttcttgatat
     4261 agaggcttta taatatctgg atacttatct ctatagaatt ctattatttg tcgtgtatga
     4321 tcagaagaag catcatcatg aatcaatatt tcaatagaga agttaccttt ttgttgaata
     4381 ataccatcta agcattgaga aataaattta tcatgattat aggtcataca acaaacagag
     4441 actaatggaa ttctattatt ctttcccata aatcaaactt tgcatatttt tatttctatt
     4501 ttttagaaat ttagcaggta taccaatata aactccccaa gcatccaatg atttccgaac
     4561 catagacatt gctccaacta cagttccttc accaatagaa catccgggat atacaatagt
     4621 atttgcgcca atatgagcaa acttacaaat tcgaacttct ccaccaataa catgagttaa
     4681 tcttttatca tgaataggac ctactaaata atcaccacta aaatcatcca ttgcactata
     4741 aatcgttgtt ctaggagata tacccacata atcctctaaa accactccat atcctccata
     4801 tatagctaca taagcagata tatgtatatt ggaaccgatg agaattttgc cagacaatat
     4861 acaaaaatcg tctatccgta cattatttcc tatatatata ttcttgggag aataaaaaga
     4921 gactttccta gaaatcagaa catttgtgcc gtatactgct aaacctatat ttgccaattc
     4981 tttttctgaa taaaaagatg tcattttttt aaaagttcaa ttatacgttc aacatcaata
     5041 gaagttaagc cagtatgtaa tggcagacaa atgacagagt tagctattct atttgcaaca
     5101 ggaagattac ttatttgagc ggaatcaagc ccacagtacg ttgaaaagtt tgttattaat
     5161 ggataaaaat atctccgacc acacacacca tttcgtttca ttttttcata aagttcatca
     5221 cgagtaatac catactttac agaatctata aagataggaa aataagaata attatgacgt
     5281 atattatgca tttcaggcat ataactaata ccatcaatac ctcctaatcc ctcacgatat
     5341 cttttagata tttgatgtcg gtattcaata gcagaatcaa cagcttttaa attaagtagt
     5401 ccgtatgcag aacgaatctc gtctattttc ccattgattc caggagccac aatttgagtt
     5461 tcaccagcaa aaccaaaatt cttcaaaaaa tcaactctct ctttaatctg ccggtcatga
     5521 caaactaatg ctcccccctc aattgtatta taaaccttag ttgcatgaaa acttagtgtg
     5581 gacatatctc caaactctag aagagatttt ccatctacct ctactccaaa agcatgagcc
     5641 gcatcataaa taacttttag tccatattta tctgcaatat cctggatagc aataaaatcg
     5701 caaggatttc catagacatg aactggcata atagctgtcg tcttaggagt aatagctgct
     5761 tcaatcttat tcggatcaat attgcaagtt ttaggatcaa tatccacaaa cacaggctta
     5821 atgccattcc accataaagc atgcgttgtt gctacaaagc tgtatggtgt tgttataact
     5881 tcaccagtaa ttctcaaagc ttgtaaagag caaattaaag gcaaagtacc atttgtaaac
     5941 aaagagatgt atggtacttt caagtattgg cacaaagctt tctccaattc ttgatgataa
     6001 tacccattat tggtaatcca tttacgcttc catatatcct ctaaatatgg taaaaaatcg
     6061 tctaaagaag gcaataaagg cgaagttaca gttatttgat tctcttccat aattaaacta
     6121 tatttttaaa actgattttg agaaatgaaa ttgcttccct catcacctca aagaacctct
     6181 caatatcctc cacatcaatc tctcccaacg cacaaagccg gaatgtattc gttgtggaaa
     6241 tcttacccgg gtagatcgta aagccacgtt catagcagta atcatgaacc ttatcaaaat
     6301 cccagagggg atcatcagga tacaatacag aaacaacaag acccgactgc cattcacgtt
     6361 tgatcgcata ctgaagacca agctcttgca aacctttatg gatggcttca aagaccctct
     6421 tgtgacgggc gaatttagcc tcttcaccta ctgcaaaata ttcatcaaga gcctgacggg
     6481 cagcgtaaac ggtttgaaca ggaggagtaa aatgcatctc gcccgtcttc tcaaagtaat
     6541 cgtattgtaa atagaggtta caatagtagg aacgtttcgg ataatccctt gaagcacgta
     6601 tcagggattc atcacctatg ataaaggaaa gccccgtcat ggcctgaagg cctttctgag
     6661 ccgaagccat acaaaagtca acattatcct tcccgatatc aaaaggaatc atacccaggg
     6721 aggaagtggt gtcgacaaca aaaacggcac cgtgcgaatg ggctattttt ccgatctcac
     6781 ggatggggtt caagataccc gtacccgttt catggtgcgt ggtatagacc aaagcgatgt
     6841 ccggattgtc ggaaagcgtc ttttcgatta ccgacaggtc gggaagttcg taaacggaaa
     6901 acttcaaatc gatatgggga agaccgtaat attcgcagac ttccaccgca cgggtgctgt
     6961 aggcaccgtt attgacaacc agaactttct tatccgcagg aagaagagag ttcaggcaga
     7021 tatcgatatt gatcgtaccc gagccgcaaa acaggacggc cgtatgtttg gagaggtctc
     7081 catgcgcaac gcggaccagg tcgtcacgta actgtttcat catacccgca aactctttct
     7141 cacgcggaca gatatcggga acaacctgcg ccagcttcac cgtatccgtc gtggtggcgg
     7201 gacccggatt caaaaggatc tttctttcga tattcatgaa tgcgtatctt ttaaaaatgc
     7261 cataaaatgc tctttattct ctaccggagt agtcgtaggg cgacccagat catcacgtga
     7321 atcgatccgg accttaattt caagaagaac cgggccggac aggccggaca gcttctcaag
     7381 cgcacacgaa agcccttcct tgtcggaggc agtcagtaca tgcgcataac cgcaaccttt
     7441 cgctatcgag gcgatatcca gacggaaacc gagcgtgggt tgaccgccga cagattcatg
     7501 ggcaccgtta ttgaaaagga cgtgcctgta attcttggga gaaagatcgc cgatattgct
     7561 gacagcaccc atgtgcatga taaaggcacc gtcaccgtca agacagtaga cacggcggtc
     7621 aggcttctca agggcaaccc ccagggcaat ggaagaactg tgacccatgg aacccacagt
     7681 taggaaatcc cttgcgtgcc cctgcccttt cgattcacgg tactcgaaaa gctcacggga
     7741 gagcttgccc gtggtggaaa ccacaatgtc attgtccccg aggtggtcga caacctgcat
     7801 tagcgcctcc tcgcgggaca gaggatagtc attcaaggct tcctgacgca atttatattt
     7861 tccaaacgta tctttacgga tgacaatcgc atggggaatc gaccggctct tcgccgagac
     7921 aaccgcgtca tggatctgcg ccagggcctc gtcttcatcc gtatccagaa ttataaaagg
     7981 aattttcatg gctttcagaa gatcaagggt aacctcgccc tgcttcttat gctggggttc
     8041 gtctttcgtg ccgggctcac cgcgccaacc gaccagcaaa agaagaggaa ggctgtacac
     8101 tttctcgtcc gcaagggaca agaggggatt caccgtattt cccagaccgg agttctgcat
     8161 ataaaccaaa ggaacgttgc cagaagccat ataataaccg caggcaatgc ccaccgcgga
     8221 accttcattg gcggcgatga tatgcttacc acgcggagca tgatccgtga tataggcgca
     8281 aatattcttc aaaagggaat cgggaacacc cgtaaagaag tcaacaccgt gatgaaggaa
     8341 cgtatcgtat atcttttcta cacttaccat aaccgtctga tttatttagt gcccggaatc
     8401 aattccagaa tttccttgat aggcatacaa agcggacgga cctcctcggc gcgctcgttt
     8461 tcaaggatgg tcctggccac gttcatcatg gccggataag cggcacggag aaggtggttg
     8521 gcgtaaatga ctacgttggc accccattcg tgaagttcgg attcgtgcac atggtcataa
     8581 gtcgtcggaa caacgacaat gggaacatgg gcgtattctt tgcggaaagt ccggcagaac
     8641 tcacggatat cctcacccga cttatccttg ctgtggatca tgatgccgtc cgcacccgcc
     8701 tgtacatagg cataagcacg ttcgagggcg tcactcatgg gtttgccggc aataaggctt
     8761 tcgatacgcg caatgatcat aaagtcaccg gtgacctggg cattcttccc tgctctgatc
     8821 ttatcgcaga aaccctcgat actatcctga gtctggatag cgtcagtacc aaaaagagaa
     8881 ttcttcttca gaccgacttt atcttcaatg attaccgcag aaatgccgtg acgttccaga
     8941 gtgcgcacag taaagacaaa gtgttcgatc ttgccacccg tgtctccatc aaaaataata
     9001 ggcttggtgg tacattcaag gatattgttc aggtcctgta aacgggtggt aaggtcgacc
     9061 gcttcaatat ccggtttacc cttactcgtg gagtcggtca ggctgctgga ccacatgccg
     9121 tcaaagacct cgcgcttatc acccttctgg acttcaagat tctcaataat cagaccgcaa
     9181 agaccgtcgt gagcctccag gatacggacc acaggcttgg cctggatcag gcggcggagg
     9241 gacttaagac gtacgtcagg ggtagtcccg atcgccttga tatccttgtc gagcgaggag
     9301 gagttgatgc cccgggtata agggatctcg attaccttgc ccccctgggc gttcatcacc
     9361 tcaaaaacct gttcgcgcac ctcgcgcaac gggcccgttt tccagtcgtc gccgtggatg
     9421 atatagtcag gcttgagttt ttccagattc ggaacatagc tccaatcctc ctggggaaca
     9481 acttcgcaaa cccctttgat attctcaaca acctccttac gctgatcata ggtaaggtaa
     9541 gggaggcgtt tgtgttcggc gatggccttg tccgtcagca gaccgacgat gacatcaccg
     9601 tatttagtag cttcatgaat aatatggatc aaccccggat gcatgatatc cgcggtcata
     9661 ccgacataga ttttcttgtt catatatgga aaagatttgt ttttaacaat agcggatgat
     9721 gtgctcctca gcatacgaaa ggtcggcttc atcatcgatt tcataccatt taagaccctc
     9781 caccctgagc acacggacag gggaaacgga acgggacatg cggagcagtt cgtactcgta
     9841 acccagttta ggctgggact ccaggatggt cgcataatcg gcgcacatcc ggcggtagaa
     9901 agtattggaa agtttatgga taccgaccag ctcgcctttt gcctcaaggg cgtccttgtc
     9961 taccgaacag gaagtaagga tgtgattgcg gtcatattcc acataatact gatcctggaa
    10021 cttggtcaga gaagagacaa gcatcacatc cgggaattcg tcatccagca gcgagaggag
    10081 ggccttgcgt tcaaaaacaa ggtccgattc aagcagcagg aaactgtcat cgcctatcac
    10141 gtcacgcgta ttgtacagag tgtacatact gttagtatcg gcataacggg gactgaaaca
    10201 ggtctctatc tgggggaaat ccgcctgaag ggcttcataa gcctcttttt tataacccgt
    10261 accgaggatg atacgttcga taccgcagga aagaagggtt tcgatagagc ggataatcat
    10321 aggttttcca ccaacctcca caaaaccttt gggcacaagc tcggtataat gcccgaagcg
    10381 ggtaccaaga ccggcagcca tgatcattgc tgttttaatc atgaatttca gagggaatta
    10441 atataagtga attcaattgt tgcttgaaat aacagtaaat cgcaaaaatc gacaggacag
    10501 aaacaaatcc tgaaaaaagg gcagtacgca tcagcatgac agtccaggaa atgtcagcag
    10561 aaacgaagtt cttgaccata aacacacccg tagtgcccag atagccgaaa gaatcggcca
    10621 aataaataat aaaaacagcc gtactaacca ccctaaggga agcaatcaga cgttctatca
    10681 ggtaagtgaa aggaatatac cccatataca gaccaagacc ggaaagaatc atccaccaaa
    10741 taggagaaag aaaaccgtac acataaagca atgtggaaaa aaccattaag gaaccgcctg
    10801 tgacggcgat gcaataaatg atattaagag ccaaacggtt attacggaca aacacaatca
    10861 ggaacatcag tacaaggaca aaaacggcaa tgggaacctc tgtctgagta aagatcattg
    10921 caccctcaat atggagctcc ttccaaatat cggcagcgaa agagtcacga agctcacgga
    10981 acacggtcag ggcaccgtaa aaaacaacca gcatgcagat tccccaaaag aattgcctca
    11041 aaaacttacg cctgtcttta ccatccatcg gagcacgttt ggtacgctgt atgatatctt
    11101 gctcattggg agccggaatc tgattgagaa gccagctgca aagcaacata acagggtata
    11161 ccaacaaacc ggtggtaaaa ggcatccaat attccgacac atgcaaatta tccatcacga
    11221 attgtcccaa ggttttcacc aaaccggaag agactatcaa agcaacgctc agcccgacat
    11281 tcaatatttc actgatacga cgcccttcga tatagctaaa aatgacaccc cagatcatac
    11341 ccaggggaag accgctcaga aaaatagaac acaccttcaa aggaaccgga agaagtgcaa
    11401 aacccaacaa agcaacttcg gaaaaagtaa gcagccctat tatataatag atgcggtgac
    11461 ccgctttcat cgaaggcaga atacgaacac cgatgaactt ggaaagggcg tagccgataa
    11521 tctcagaaag gacatacagg attttgacat cgaatcccca aagaatctca ccttcataaa
    11581 tggctgcggt aaatggctta cggtaggcat aggcacaggt ataaaccaga aaaatcaaaa
    11641 cgctggcata gagagccaaa acgtaaaggg gagaacggga aagaagggaa cgaatcattc
    11701 gtgtaaacat ataaatcatc caatgtaacg acaattcaaa ttacgattta acagggctga
    11761 atgtaaaaat attctattcg ctaaataaaa aacactcaga aatctattta tccataaata
    11821 aagaattata aggattagct atatttgaag aagtcagtat tattaatttt tttactatct
    11881 aattcaggca tctattcctc attagaggtc gttatatcaa tcatcttcaa catatattgc
    11941 ccatattggc tctttaacat cggttgtgcc aatactttca tcttctcgga agaaatccaa
    12001 ccttgcctaa aagcaattcc ctctaaacaa gcaactttca gcccttgacg tttttctatc
    12061 acttcgataa aagtgctcgc ttcggacagc gagtcatgcg tacctgtatc caaccaagca
    12121 aagccacgcc ctaataattt gaccttcagt tcctggtcta acaaaaactg ttgattaaca
    12181 gtagttattt ctaattctcc acgaggagaa ggtttgatat tttgggctat ctccaccact
    12241 ttattaggat agaaataaag tcctacaaca gcataatgtg atttaggtat ttgaggcttt
    12301 tcttcaatac tgagtacatt tccctcctga tcaaactctg caacgccata acgttcagga
    12361 tcacttaccc aataaccaaa aacggttgct ttgttttctg attcagcaga atgaaccgct
    12421 tcacgcaaca tgcgcgtaaa accttgccca taaaaaatat tatctcctaa aactaaacaa
    12481 acagaatcac tgccaataaa cttctctcca ataataaatg cttgtgctaa accatcagga
    12541 gaaggctgct ctgcatactc aaagtgtact ccaaaatcag aaccatcgcc cagtaaacgt
    12601 tgaaaacccg gtaagtcata aggagtagag ataattagta tttctcgtat cccagctaac
    12661 ataagtacag agatggggta ataaatcatg ggtttatcga aaattggaag aagttgtttg
    12721 cttactcctt tagtaatagg atataaacgt gtaccagatc ccccagctaa aacaatgcct
    12781 ttcataagtc aaataaataa aaaaaataga attattctat tccatttcac tataaggata
    12841 tggattctct tccaaatttc tcaaattatt gattgcctct tttttatctt cagaaagttc
    12901 tttatctttc caactttcta tgatagtatg cgcctctttc gccaactcct cttcaaacac
    12961 ctcaccataa caataagtca acaactggca tttcaataaa gtagcaggaa gttggtcaag
    13021 cacgtcccaa caacgattga gaacaacttg ctttttctcc tccttgtcac cctgattata
    13081 gatggttgca ttgtaaccca tcaataatgc cagacagatg tttgcttcct cttcgggagt
    13141 agcaccacgc tgaggataca acgcatcgga ttgttctaaa acttctttgt tcaactgacg
    13201 gaaatgatcg gtataaatag gagcaccatc cacacctaaa tagagtaact cgtgcgcgag
    13261 actctgtaat tgttcaattt gagaagtgag tgtattcata acttaaatga cacgtaaata
    13321 acttttagga actttgacgc tggcgctcaa tacaccggca atacgaataa caacataagt
    13381 tttgttggcc tcgctggcaa gttcgccctc gacaccacag aaatcacctt taactacctg
    13441 aaccctgcta ccaacagata aatggtcatt atcgaaactg acgccattcg gatctaaatc
    13501 catgacaaat atgaagtcct gcatctgttt atcaggaact atcagcatgg ccctggtaag
    13561 caggtctttc atataaaaaa gctggatatt gtatttatta gaaatatcac aagcatcttg
    13621 cttggtagct tggatgaaga taagattctt aataacaggg acttccaccc gttttcgacg
    13681 atatttcaac tgccggatga caaactgagt gggaagatag taattgagat caagttcagt
    13741 cttcaatttt tcaagagagt cacgaatagc aaactcttgt ttatctcggg tacgggcggc
    13801 aaaccaatac ttctgttgtt cagacattta cgatttatac ttggggaaat tttcctttgt
    13861 ttcgggtgcg cttcgcggtt tgaacgagac atcttttctc tttcaaaccg tcaaatttta
    13921 cgaaacattt ttagaagttg agaacgaacg aatgtgtttc aaaaaacgtt cgt
//
