LOCUS       gnlProkkaNCPOKNDE_11   14295 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NCPOKNDE_11.
ACCESSION   gnlProkkaNCPOKNDE_11
VERSION     gnlProkkaNCPOKNDE_11
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 18:00:47
            Original ID  :: gnl|Prokka|NCPOKNDE_11
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 735894
            Orig. end    :: 750189
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14295
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:9295]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9295
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..14295
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14295
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(514..1317)
                     /locus_tag="ctg11_620"
                     /transl_table=11
                     /translation="MATTYDGINYFPIAVNFMEENAMEVIEAKYGMKGLAIVLKLLCKI
                     YKEGYYIPWGEEQCLIFANKTGKEADAEEVQGIIEIMIEKGMIDRGSYAEHKVLTSEAI
                     QKVWIEATKRRKRNWTAMPYLLIKPKETCNEEKTVCTQNVEQDAGSDAKNACNTEQSKV
                     KQSREFPPSAPPRGKEEEVNATPVSMPGYAFNTMTHNYVGLMGNLERFGITDEKEIEAI
                     LRLSDYGRKGTPVWKLICSTNWSNIGAKGKYMIAALNRAKKRSGT"
     CDS             complement(1367..1714)
                     /locus_tag="ctg11_621"
                     /transl_table=11
                     /translation="MKKNRKAVSKNEMMKGKWKRQIMLEKDYTEQCSEWMAERLEALIE
                     YMQYGHAAVAYMKQDGTFKLVKGTLVGYEKDFGKQYDPMEIKNTVVYRDVEQQRWMTFK
                     IENFMEWRAIV"
     CDS             complement(1855..2193)
                     /locus_tag="ctg11_622"
                     /transl_table=11
                     /translation="MNDNLVTIEVNGKVIFAGKADLQFSLNQKVREPLRITKGKGKLME
                     ALTESFIKGGINSMENRPIEELQETIKEYLTFEYQRKGIATEPNKRSFLSELKKYARAF
                     RKKRDESE"
     CDS             2715..3239
                     /locus_tag="ctg11_623"
                     /transl_table=11
                     /translation="MSEQQKYWFAARTRDKQEFAIRDSLEKLKTELDLNYYLPTQFVIR
                     QLKYRRKRVEVPVIKNLIFIQATKQDACDISNKYNIQLFYMKDLLTRAMLIVPDKQMQD
                     FIFVMDLDPNGVSFDNDHLSVGSRVQVVKGDFCGVEGELASEANKTYVVIRIAGVLSAS
                     VKVPKSYLRVI"
     CDS             3243..3728
                     /locus_tag="ctg11_624"
                     /transl_table=11
                     /translation="MNTLTSQIEQLQSLAHELLYLGVDGAPIYTDHFRQLNKEVLEQSD
                     ALYPQRGATPEEEANICLALLMGYNATIYNQGDKEEKKQVVLNRCWDVLDQLPATLLKC
                     QLLTYCYGEVFEEELAKEAHTIIESWSNRELLKAEKEIAESLNNLEANPYPYSELHE"
     CDS             3725..5008
                     /locus_tag="ctg11_625"
                     /transl_table=11
                     /translation="MIRSFLSRSPLYVLALYASVLIFLVYTCAYAYRKPFTAAIYEGEI
                     LWGFDVKILYVLSEIIGYALSKFIGVRILPSMKAGHRIYYIIGLLTFSEVALLGFALLP
                     VPLKVCSIFLSGLPLGMIWGVIFSYIEGRRISEILNVGLSVALIVSSGLVKTLGQFVMD
                     NLHVSEYWMPFTTGLLVYPVMLLCSWLLNQIPAPNEQDIIQRTKRAPMDGKDRRKFLRQ
                     FFWGICMLVVFYGALTVFRELRDSFAADIWKELHIEGAMIFTQTEVPIAAFVLVLMFLI
                     VFVRNNRLALNIIYCIAVTGGSLMVFSTLLYVYGFLSPIWWMILSGLGLYMGYIPFTYL
                     IERLIASLRVVSTAVFIIYLADSFGYLGTTGVFMVKNFVSADISWTVMLMRTALFSGFV
                     SVLSIFAIYCYFKQQLNSLILIPSEIHD"
     CDS             5001..5720
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.5; E-value:
                     4e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_626"
                     /sec_met_domain="NTP_transf_3 (E-value: 3.5e-14, bitscore:
                     49.0, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKTAMIMAAGLGTRFGHYTELVPKGFVEVGGKPMIIRSIETLLS
                     CGIERIILGTGYKKEAYEALQADFPQIETCFSPRYADTNSMYTLYNTRDVIGDDNFLLL
                     ESDLVFERKAILSLLDDEFPDVMLVSSLTKFQDQYYVEYDRNHILTSCSVDKNALEAKG
                     ELVGIHKLSNTFYRRMCADYATILESQPKLGYEYELLRMSRSVSPVRVLRVEGLKWYEI
                     DDEADLSYAEEHIIRYC"
     CDS             5740..7041
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 214.9;
                     E-value: 2.2e-65)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_627"
                     /sec_met_domain="CTP_transf_like (E-value: 1.9e-11,
                     bitscore: 39.9, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 6.1e-121, bitscore:
                     398.4, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 3.5e-63, bitscore:
                     208.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKIYVGMTADIMHPGLIHIIHEATKYGDVIVGLLTDKAIAEHK
                     RLPYLTYDQRKEVVENIKGVCEVVPQEDWSYVPNLEKLKPDYIIHGDDWKTGPLREVRE
                     QVFEVMNAQGGKVIEIPYTRGINSSSLDKDIKAIGTTPDVRLKSLRRLIQAKPVVRILE
                     AHDGLCGLIIENLEVQKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAVIIEDKVGLKKNSLFGTDAIQTQDS
                     IEGFCDKIRAGKNAQVTGDFMIIARIESLIAGKPMSDALERAYAYVQAGADGIMIHSKD
                     KSGEDIREFCRTFRKEYAHVPIVVVPTTYDHVHESELHEWGANVVIYANHLLRAAYPAM
                     MNVARTILENERAEEVRPLCMPIKEILELIPVTK"
     CDS             7053..8189
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 70.6;
                     E-value: 1.9e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_628"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.1e-20, bitscore:
                     69.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.7e-19, bitscore:
                     64.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSVEKIYDTFLHHGVDFFTGVPDSLLKNICAYITDHAPRGKHII
                     AANEGSAVGIACGYYMASGNVPLVYMQNSGLGNTVNPLLSLADEKVYSLPLLLLVGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMKIPFIILDTDEDEALAQIHDAVVSAKSRSIPHAIV
                     IRKDTFGKYKLRQEALNDYPLSREEALMQVVDHLGDNDIVVSTTGKLSRELFEYRESKG
                     QGHARDFLTVGSMGHSSSIALGIALEKPDRRVYCLDGDGAFIMHMGAVSNIGDLSPKNY
                     RHVLFNNGAHESVGGQPTLGFRLDIASIAKGCGYAHVLTASDKEGLSCALEKLSGLSGP
                     VLLEIKVRIDSRDDLGRPTTTPVENKEHFMAFLKDTHS"
     CDS             8186..9295
                     /NRPS_PKS="Domain: Aminotran_5 (30-293). E-value: 4.5e-34.
                     Score: 109.8. Matches aSDomain:
                     nrpspksdomains_ctg11_629_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 81.8; E-value:
                     7.7e-25)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_629"
                     /sec_met_domain="Aminotran_5 (E-value: 5.4e-30, bitscore:
                     100.1, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIERKILLNPGPATTTDTVKLAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGDLSKHTAVLFCGSGTINIDICLNSLLPADKKVLVVNNGAYSTRAVEVCEYY
                     GLPHIDLKFSVYELPDLSVIEKALSDNPDIALVYTTHHETGTGILNPIREIGKIAHSHG
                     AVFVVDTTSSLGMIPFDIGKDNVDFCMASAQKGLQAMTGLSFIIGDESLIRASRDYPKR
                     SYYCNLYLQYDYFEKTGEMHFTPPVQTVYAARQALDEYFAVGEEAKFARHKRVFEAIHK
                     GLQELGLQYAIKREWQSGLVVSVLYPDDPLWDFDKVHDYCYERGFTIYPGKISTTNTFR
                     LCALGEIDVEDIERFFEVMKSVNTVLVNK"
     aSDomain        8276..9064
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg11_629_Aminotran_5.1"
                     /evalue="4.50E-34"
                     /label="ctg11_629_Aminotran_5.1"
                     /locus_tag="ctg11_629"
                     /protein_end="293"
                     /protein_start="30"
                     /score="109.8"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGDLSKHTAVLFCGSGTINIDICL
                     NSLLPADKKVLVVNNGAYSTRAVEVCEYYGLPHIDLKFSVYELPDLSVIEKALSDNPDI
                     ALVYTTHHETGTGILNPIREIGKIAHSHGAVFVVDTTSSLGMIPFDIGKDNVDFCMASA
                     QKGLQAMTGLSFIIGDESLIRASRDYPKRSYYCNLYLQYDYFEKTGEMHFTPPVQTVYA
                     ARQALDEYFAVGEEAKFARHKRVFEAIHKGLQELGLQYAIK"
     CDS             9308..10126
                     /locus_tag="ctg11_630"
                     /transl_table=11
                     /translation="MLKKRLDYSQLKVIQLNILKDVDAFCRENNITYYLTYGTLLGAVR
                     HQGYIPWDDDIDIAMPRKDYEKFLSNYNLNGSKKNVYQVVAIELNNAYPYPFGKVQDLS
                     TVLLEYSDINYPLGINIDIFPIDGLPVDLKKSDKHFLKIKWLMMIMNLKKVKITIKRSF
                     LKNLILLIGKILTLLIPYRFIVCKMSYIAQRYDYEKSDYVSNLSCPDGKHERTSKRVFE
                     NSIEILFEGNNFYAPIGYHEWLHNIYGDYMKMPPVPERVSHHKFEIYKIL"
     CDS             10129..11124
                     /locus_tag="ctg11_631"
                     /transl_table=11
                     /translation="MCSKDNFLQEVRALCIFTVILLHVPFQGHDNISFNTWLMSKQLIT
                     FPVAVFFFLSGYFYSFRNYKSRIVKLLCPFLFWNMSVHLIKFIRGESGFNIENFLLGNG
                     LPYYYLAVLLQIVLFHYIIFKYWSEMVYRVLSISISIISLMAYYYFSISYSIHFNCYLY
                     FPFWILFYTLGTFGKKYWRNLISKIPFCVILLFILISVFLMFFEANLMYYILFQEGIAG
                     SQVKFSSWVYSILIVLLLLKIDYSIDENVTRNFGTLIGDYSYGVYLIHIFILSLIYKLC
                     IVVFNDNYNVLLPFIAASITLVISVFMIYILNKCLPPFILKFLGLYVKSN"
     CDS             11108..12280
                     /locus_tag="ctg11_632"
                     /transl_table=11
                     /translation="MLKVTDECTACGACLSICPKNCISFKSNEEGFLYPHIDIEKCVDC
                     DLCSKVCFLNDHITPTFRENDISYYAAKAIERCNLSSSGGIFPLLAESVLKNDGVVIGA
                     AWDDKFNVKHILIKSKSELPLLCGSKYIQSNTEKVFKIVKEHLSIQTVLFSGTPCQVKG
                     LKTFLGKDYDNLITVELVCHGVPSPLVFRRYLNGVLKYNNLDISQCSKINFREVKDDIY
                     RFVIYNKTKIPFYEQYTNLYTKTFLQNLFLRNSCYNCKCKLENSVGDFILGDFWGCRDF
                     YPEFYDPKGVSLVIVCTERAKKIWLNLKLSRIEVKKKIVFRSNRHLLKSASYNRNRDLF
                     FKTFIHEAEISLDDILMGYTNKDIWVKVKGLIISVLRFVGLFQLVQLYRK"
     CDS             12277..13335
                     /locus_tag="ctg11_633"
                     /transl_table=11
                     /translation="MKIALLTLPFVNNYGGILQAYALKHFLELRGHSVCIIDRNSNFKI
                     SFIDILRLAKRKFLGNRIRNFAYFKKQYLLPMTSEIITNKEMLLLDEKYQFDIYIVGSD
                     QVWRAIYYRDIKYNFYLDFVSSKRKISFAASFGISSWEYTNTETDIIAKLLMDFSFVSV
                     REDTAVRLCSDYLNINAVQFLDPTFLLDKNEYCCLADCFYSSKKIDIFAYIMGPDSSKD
                     KLIKIISDYSGLSVQSITQSKFSFKKNESIQEWLQNFYKSKFVVTDSFHGLAFSLIFNK
                     PFIVCGFSNRGMGRYESLLRYFSLENRLLYSLEDLKELNLSTIWDINWKEVNAKIAENK
                     RFVLELMQTVGV"
ORIGIN
        1 caaactggtc gattttgttg gcaggaagaa agaccgcatt gtgtatttgc aatgtgcacc
       61 tctgctcaat gatgattttc aagtggagca aatgtacaac acgctggaga tgatacaaga
      121 caattatgaa aagtgggtcg tttctatgga cgataccaca ttgccctcca aagaagggat
      181 tcgtcacata caagtctggc aactgactga aatactatag tctgacaatc ttttttgatt
      241 gctttgatgt ccggatgatg ccgtttacga agttaacatc ttgttgttta cgaagttaat
      301 atcataattt tacgaagtta aaatcgtatc ttcgggaagt taacttcctg aagtcacgat
      361 tttaacttcg tattagtgct ttttgaatcg cttttcaacc ccttgagaat cagtgtccgt
      421 ttccggagga aaacagctgc gttctttaat tgattgcaag caaacagcat tttccagaat
      481 ataaaatgta ctgtttgtca gaaaagttct tttttaggtt ccgcttcttt tctttgcccg
      541 gttcaacgct gcgatcatgt attttccttt tgctccgatg ttactccagt tcgtgctgca
      601 aatcagtttc catacagggg ttccttttct cccgtaatct gacagtcgca ggattgcttc
      661 gatctctttt tcgtctgtta ttccgaatcg ttccaggttt cccattaatc ccacgtagtt
      721 gtgtgtcatt gtattaaatg cgtatccggg catactgacc ggcgtagcat tgacttcctc
      781 ttccttcccc cttgggggag ctgagggggg aaattctcta ctttgcttta ctttactttg
      841 ttcggtattg catgcatttt ttgcatcaga gcctgcatcc tgctctacat tttgcgtgca
      901 gacggtcttt tcttcattac atgtctcttt cggttttatc agtagataag gcatggctgt
      961 ccagttcctc tttcttcgct tggttgcctc tatccatact ttttgtattg cttcagaggt
     1021 cagtacttta tgttccgcat agcttcccct gtctatcatt cctttctcga tcattatctc
     1081 gataatcccc tgcacctctt ctgcgtctgc ctcttttccc gtcttgttgg cgaaaataag
     1141 gcattgttcc tcaccccacg gaatataata tccttcttta tatattttgc atagaagttt
     1201 cagtacaatc gcgagtcctt tcatgccata ttttgcttct attacctcca ttgcgttctc
     1261 ttccataaaa ttcacagcta ttggaaagta atttattcca tcgtatgttg ttgccataat
     1321 tgttaagttg ttatgttgct gattaattgg tcactgaaag attctcctat acgatcgctc
     1381 tccattccat gaaattctct attttgaagg tcatccacct ttgttgctcc acatcccggt
     1441 agaccactgt gttttttatt tccatcggat catactgctt tccgaaatct ttttcgtatc
     1501 ccaccaatgt tcctttcacc agtttgaatg ttccgtcctg tttcatataa gctacggctg
     1561 catgtccata ttgcatatat tctatgaggg cttccagtcg ttctgccatc cattcggagc
     1621 actgttctgt gtagtccttt tcgagcatga tttgtctttt ccattttcct ttcatcattt
     1681 cgtttttcga tactgctttc ctgttctttt tcataattga ttttttaaag tttattaatg
     1741 agttattgtc gggcttttat ttttacccat ggcaaagtac ggtaataagt tttgaataga
     1801 ctaatcctgt aaaagtactt tagaaagggg cttttacagg attttaacaa tcggttattc
     1861 gctttcatct cgctttttcc ggaatgctct ggcatatttt ttcagctctg atagaaaaga
     1921 acgtttatta ggctctgtag caatgccttt gcgctgatat tcaaaggtga gatattcttt
     1981 tattgtttcc tgtagttctt caatgggtct gttttccatg ctgttgattc cgcctttgat
     2041 aaagctttcg gtaagtgcct ccattagctt tcctttgcct tttgtgatgc gtagtggttc
     2101 tctaaccttt tgattgaggc tgaattgcaa gtcggcttta cccgcaaaga ttacttttcc
     2161 atttacttcg atggttacta agttatcatt caatgagata actacttttt ttcttccata
     2221 atgttagtta ttaaatgaat ttatgaaagg acaaagtttg tataaaaaaa tataaatata
     2281 aaagaatacc ggagtttttt tagtttaaag ggagaatctt gaagtgtaag gatcttgtta
     2341 ttagttattt atcttaagat ataggcgttg tttcaaaaaa cgttcgtttg attgaacaaa
     2401 ggtaaggagt ctgttttaat gtacaaaata tttagtggat aaaattttat caaagatttt
     2461 atgttgctga ttctcaaata tatatagagc aaaaaaagtt ctttgttcag ctactttaca
     2521 atattcattt tttcatcgaa aaaaaactca aaaatgctgt ttcaaaagac gaacgttttt
     2581 tgaaacacat tcgttcgttc tcaacttcta aaaatgtttc gtaaaatttg acggtttgaa
     2641 agagaaaaga tgtctcgttc aaaccgcgaa gcgcacccga aataaaggaa aatttcccca
     2701 agtataaatc gtaaatgtct gaacaacaga agtattggtt tgccgcccgt acccgagata
     2761 aacaagagtt tgctattcgt gactctcttg aaaaattgaa gactgaactt gatctcaatt
     2821 actatcttcc cactcagttt gtcatccggc agttgaaata tcgtcgaaaa cgggtggaag
     2881 tccctgttat taagaatctt atcttcatcc aagctaccaa gcaagatgct tgtgatattt
     2941 ctaataaata caatatccag cttttttata tgaaagacct gcttaccagg gctatgctga
     3001 tagttcctga taaacagatg caggacttca tatttgtcat ggatttagat ccgaatggcg
     3061 tcagtttcga taatgaccat ttatctgtcg gtagcagggt tcaggtagtt aaaggtgatt
     3121 tctgtggtgt cgagggcgaa cttgccagcg aggccaacaa aacttatgtt gttattcgta
     3181 ttgccggtgt attgagcgcc agcgtcaaag ttcctaaaag ttatttacgt gtcatttaag
     3241 ttatgaatac actcacttct caaattgaac aattacagag tctcgcgcac gagttactct
     3301 atttaggtgt ggatggtgct cctatttata ccgatcattt ccgtcagttg aacaaagaag
     3361 ttttagaaca atccgatgcg ttgtatcctc agcgtggtgc tactcccgaa gaggaagcaa
     3421 acatctgtct ggcattattg atgggttaca atgcaaccat ctataatcag ggtgacaagg
     3481 aggagaaaaa gcaagttgtt ctcaatcgtt gttgggacgt gcttgaccaa cttcctgcta
     3541 ctttattgaa atgccagttg ttgacttatt gttatggtga ggtgtttgaa gaggagttgg
     3601 cgaaagaggc gcatactatc atagaaagtt ggagcaatcg agaactttta aaagctgaaa
     3661 aagaaatagc tgaaagtttg aataatttgg aagctaatcc atatccgtac agcgaactac
     3721 acgaatgatt cgttcctttc tttcccgttc tcccctttac gttttggctc tctatgccag
     3781 cgttttgatt tttctggttt atacttgtgc ctatgcctac cgtaagccat ttaccgcagc
     3841 catttatgaa ggtgagattc tttggggatt cgatgtcaaa atcctgtatg tcctttctga
     3901 gattatcggc tacgcccttt ccaagttcat cggtgttcgt attctgcctt cgatgaaagc
     3961 gggtcaccgc atctattata taatagggct gcttactttt tccgaagttg ctttgttggg
     4021 ttttgcactt cttccggttc ctttgaaggt gtgttctatt tttctgagcg gtcttcccct
     4081 gggtatgatc tggggtgtca tttttagcta tatcgaagga cgtcgtatca gtgaaatatt
     4141 gaatgtcggg ctgagcgttg ctttgatagt ctcttccggt ttggtgaaaa ccttgggaca
     4201 attcgtgatg gataatttgc atgtgtcgga atattggatg ccttttacca ccggtttgtt
     4261 ggtataccct gttatgttgc tttgcagctg gcttctcaat cagattccgg ctcccaatga
     4321 gcaagatatc atacagcgta ccaaacgtgc tccgatggat ggtaaagaca ggcgtaaatt
     4381 tttgaggcaa ttcttctggg gaatctgcat gctggttgtt ttttacggtg ccctgaccgt
     4441 gttccgtgag cttcgtgact ctttcgctgc cgatatttgg aaggagctcc atattgaggg
     4501 tgcaatgatc tttactcaga cagaggttcc cattgccgct tttgtccttg tactgatgtt
     4561 cctgattgtg tttgtccgta ataaccgttt ggctcttaat atcatttatt gcattgccgt
     4621 cacaggcggt tccttaatgg ttttttccac attgctttat gtgtacggtt ttctttctcc
     4681 tatttggtgg atgattcttt ccggtcttgg tctgtatatg gggtatattc ctttcactta
     4741 cctgatagaa cgcctgattg cttcccttag ggtggttagt acggctgttt ttattattta
     4801 tttggccgat tctttcggct atctgggcac tacgggtgtg tttatggtca agaacttcgt
     4861 ttctgctgac atttcctgga ctgtcatgct aatgcgtact gccctttttt caggatttgt
     4921 ttctgtcctg tcgatttttg cgatttactg ttatttcaag caacaattga attcacttat
     4981 attaattccc tctgaaattc atgattaaaa cagcaatgat catggctgcc ggtcttggta
     5041 cccgcttcgg gcattatacc gagcttgtgc ccaaaggttt tgtggaggtt ggtggaaaac
     5101 ctatgattat ccgctctatc gaaacccttc tttcctgcgg tatcgaacgt atcatcctcg
     5161 gtacgggtta taaaaaagag gcttatgaag cccttcaggc ggatttcccc cagatagaga
     5221 cctgtttcag tccccgttat gccgatacta acagtatgta cactctgtac aatacgcgtg
     5281 acgtgatagg cgatgacaat ttcctgctgc ttgaatcgga ccttgttttt gaacgcaagg
     5341 ccatcctctc gctactggat gacgaattcc cggatgtgat gcttgtctct tctctgacca
     5401 agttccagga tcagtattat gtggaatatg accgcaatca catccttact tcctgttcgg
     5461 tagacaagaa cgcccttgag gcaaaaggcg agctggtcgg tatccataaa ctttccaata
     5521 ctttctaccg ccggatgtgc gccgattatg cgaccatcct ggagtcccag cctaaactgg
     5581 gttacgagta cgaactgctc cgcatgtccc gttccgtttc ccctgtccgt gtgctcaggg
     5641 tggagggtct taaatggtat gaaatcgatg atgaagccga cctttcgtat gccgaggagc
     5701 acatcatccg ctattgttaa aaacaaatct tttccatata tgaacaagaa aatctatgtc
     5761 ggtatgaccg cggatatcat gcatccgggg ctgatccata ttattcatga agctactaaa
     5821 tacggtgatg tcatcgtcgg tctgctgacg gacaaggcca tcgccgaaca caaacgcctc
     5881 ccttacctta cctatgatca gcgtaaggag gttgttgaga atatcaaggg ggtttgcgag
     5941 gttgttcccc aggaggattg gagctatgtt ccgaatctgg aaaaactcaa gcctgactat
     6001 atcatccacg gtgacgactg gaaaacgggt ccgttgcgcg aggtgcgcga acaggttttt
     6061 gaggtgatga acgcccaggg gggcaaggta atcgagatcc cttatacccg gggcatcaac
     6121 tcctcctcgc tcgacaagga tatcaaggcg atcgggacta cccctgacgt acgtcttaag
     6181 tccctccgcc gcctgatcca ggccaagcct gtggtccgta tcctggaggc tcacgacggt
     6241 ctttgcggtc tgattattga gaatcttgaa gtccagaagg gtgataagcg cgaggtcttt
     6301 gacggcatgt ggtccagcag cctgaccgac tccacgagta agggtaaacc ggatattgaa
     6361 gcggtcgacc ttaccacccg tttacaggac ctgaacaata tccttgaatg taccaccaag
     6421 cctattattt ttgatggaga cacgggtggc aagatcgaac actttgtctt tactgtgcgc
     6481 actctggaac gtcacggcat ttctgcggta atcattgaag ataaagtcgg tctgaagaag
     6541 aattcccttt ttggtactga cgctatccag actcaggata gtatcgaggg tttctgcgat
     6601 aagatcagag cagggaagaa tgcccaggtc accggtgact ttatgatcat tgcgcgtatc
     6661 gaaagcctta ttgccggcaa acccatgagt gacgccctcg aacgtgctta tgcctatgta
     6721 caggcgggtg cggacggcat catgatccac agcaaggata agtcgggtga ggatatccgt
     6781 gagttctgcc ggactttccg caaagaatac gcccatgttc ccattgtcgt tgttccgacg
     6841 acttatgacc atgtgcacga atccgaactt cacgaatggg gtgccaacgt agtcatttac
     6901 gccaaccacc ttctccgtgc cgcttatccg gccatgatga acgtggccag gaccatcctt
     6961 gaaaacgagc gcgccgagga ggtccgtccg ctttgtatgc ctatcaagga aattctggaa
     7021 ttgattccgg tcactaaata aatcagacgg ttatggtaag tgtagaaaag atatacgata
     7081 cgttccttca tcacggtgtt gacttcttta cgggtgttcc cgattccctt ttgaagaata
     7141 tttgcgccta tatcacggat catgctccgc gtggtaagca tatcatcgcc gctaatgaag
     7201 gttccgcggt gggcattgcc tgcggttatt atatggcttc tggcaacgtt cctttggttt
     7261 atatgcagaa ctccggtctg ggaaatacgg tgaatcccct cttgtccctt gcggacgaga
     7321 aagtgtacag ccttcctctt cttttgctgg tcggctggcg cggtgagccc ggcacaaaag
     7381 acgaacccca gcataagaag cagggcgagg ttacccttga tcttctgaaa gccatgaaaa
     7441 ttccttttat aattctggat acggatgaag acgaggccct ggcgcagatc catgacgcgg
     7501 ttgtctcggc gaagagccgg tcgattcccc atgcgattgt catccgtaaa gatacgtttg
     7561 gaaaatataa attgcgtcag gaagccttga atgactatcc tctgtcccgc gaggaggcgc
     7621 taatgcaggt tgtcgaccac ctcggggaca atgacattgt ggtttccacc acgggcaagc
     7681 tctcccgtga gcttttcgag taccgtgaat cgaaagggca ggggcacgca agggatttcc
     7741 taactgtggg ttccatgggt cacagttctt ccattgccct ggggattgcc cttgagaagc
     7801 ctgaccgccg tgtctactgt cttgacggtg acggtgcctt tatcatgcac atgggtgctg
     7861 tcagcaatat cggcgatctt tctcccaaga attacaggca cgtccttttc aacaacggtg
     7921 cgcatgaatc tgtcggcggt caacccacgc tcggtttccg tctggatatc gcctcgatag
     7981 cgaaaggttg cggttatgcg catgtactga ctgcctccga caaggaaggg ctttcgtgtg
     8041 cgcttgagaa gctgtccggc ctgtccggcc cggttcttct tgaaattaag gtccggatcg
     8101 attcacgtga tgatctgggt cgccctacga ctactccggt agagaataaa gagcatttta
     8161 tggcattttt aaaagatacg cattcatgaa tatcgaaaga aagatccttt tgaatccggg
     8221 tcccgccacc acgacggata cggtgaagct ggcgcaggtt gttcccgata tctgtccgcg
     8281 tgagaaagag tttgcgggta tgatgaaaca gttacgtgac gacctggtcc gcgttgcgca
     8341 tggagacctt tccaaacata cggccgtcct gttttgcggc tcgggtacga tcaatatcga
     8401 tatctgcctg aactctcttc ttcctgcgga taagaaagtt ctggtggtca ataacggtgc
     8461 ctacagcacc cgtgcggtgg aagtctgcga atattacggt cttccccata tcgatttgaa
     8521 gttttccgtt tacgaacttc ccgacctgtc ggtaatcgaa aaggcgcttt ccgacaatcc
     8581 ggacatcgct ttggtctata ccacgcacca tgaaacgggt acgggtatct tgaaccccat
     8641 ccgtgagatc ggaaaaatag cccattcgca cggtgccgtt tttgttgtcg acaccacttc
     8701 ctccctgggt atgattcctt ttgatatcgg aaaggataat gttgactttt gtatggcttc
     8761 ggctcagaaa ggccttcagg ccatgacggg tctttccttt atcataggtg atgaatccct
     8821 gatacgtgct tcaagggatt atccgaaacg ctcctactat tgtaacctct atttacaata
     8881 cgattacttt gagaagacgg gtgagatgca ttttactcct cctgttcaaa ccgtttacgc
     8941 agcccgtcag gctcttgatg aatattttgc agtaggtgaa gaggctaaat tcgcccgtca
     9001 caagagggtc tttgaagcca tccataaagg tttgcaagag cttggtcttc agtatgcgat
     9061 caaacgtgaa tggcagtcgg gtcttgttgt ttctgtattg tatcctgatg atcccctctg
     9121 ggattttgat aaggttcatg attactgcta tgaacgtggc tttacgatct acccgggtaa
     9181 gatttccaca acgaatacat tccggctttg tgcgttggga gagattgatg tggaggatat
     9241 tgagaggttc tttgaggtga tgaaaagcgt aaatacggta ttagttaata aataatttag
     9301 ctcattcatg ttgaaaaaaa ggttggacta ttcccaatta aaggttatac agttgaatat
     9361 attaaaagat gtagatgctt tttgtcgtga aaataatata acttattatt taacttatgg
     9421 gactttgttg ggggctgtaa gacatcaagg atatattcct tgggatgacg atattgatat
     9481 tgctatgccg aggaaagatt atgaaaagtt tttatcaaat tataatctaa atggaagtaa
     9541 aaaaaatgtg tatcaagttg ttgctataga gttaaataat gcttatcctt atccttttgg
     9601 aaaggttcaa gatttatcaa ctgttttatt agaatattca gatattaatt atccgttggg
     9661 gataaatatt gatattttcc ctattgatgg attacctgta gaccttaaaa aatcagacaa
     9721 acattttttg aagataaagt ggttaatgat gataatgaat cttaaaaaag taaaaatcac
     9781 aataaaacgt tcttttttga agaacttaat attattaata gggaagattt tgacactttt
     9841 gattccatat cgatttatag tgtgcaaaat gtcttatatt gcacagaggt atgattatga
     9901 gaaatctgat tatgtttcta acttgtcttg tccagatggg aaacatgaac ggacgtctaa
     9961 aagagttttt gaaaatagta tagagatttt atttgaaggt aataatttct atgctcctat
    10021 aggatatcat gaatggcttc ataatattta tggagattat atgaaaatgc ctccagttcc
    10081 ggaaagagta tctcatcata aatttgaaat ttataagata ctgtaatcat gtgttctaag
    10141 gataattttc ttcaagaagt tcgtgcatta tgtatattta ctgtaatatt gttacatgta
    10201 ccatttcagg gacatgataa tataagtttt aatacttggc taatgtcaaa gcagttgatt
    10261 actttccctg ttgctgtgtt cttcttttta tctggatatt tttattcttt tagaaattat
    10321 aagagtagaa ttgttaaatt gctttgtcct tttttatttt ggaatatgag tgtacatcta
    10381 attaagttta ttagagggga aagcggattt aatattgaaa attttttatt aggtaatgga
    10441 ttaccttatt attatttagc agtacttctt cagattgtgt tatttcatta cataatcttt
    10501 aaatattgga gcgaaatggt atatagagta ttgtccataa gtattagtat tataagtttg
    10561 atggcctatt attatttttc catttcttat tctatccatt ttaattgtta tctctatttt
    10621 cccttttgga tattattcta tactttagga acatttggga aaaaatattg gcgtaattta
    10681 atatctaaaa tacctttttg tgtaattcta ttgtttattt taatatctgt ctttttgatg
    10741 ttttttgaag ctaatttaat gtattatatt ttgtttcaag agggaattgc cggctctcag
    10801 gttaagttct cttcctgggt gtattctata ctaattgtgt tgcttttact taaaatagat
    10861 tattcaatag acgaaaatgt tactcgaaat tttggtacac ttataggtga ctattcatat
    10921 ggagtctatt taattcatat atttatatta tctttaattt ataaattatg tattgtcgtt
    10981 tttaatgata attataatgt attattgcct tttatcgcag cttctataac attggttatt
    11041 tcagttttta tgatttatat tttaaataaa tgtcttcctc cctttatact taaattttta
    11101 ggattgtatg ttaaaagtaa ctgatgaatg tacggcttgt ggagcttgct tgtctatatg
    11161 tccaaagaac tgtatttctt ttaaaagtaa tgaagaaggt tttttatatc cacatattga
    11221 tatagaaaaa tgtgtagatt gcgatttgtg ttctaaagtt tgttttttaa atgatcatat
    11281 tactccgact tttagggaaa atgatatcag ttattatgcg gctaaggcta ttgaacgatg
    11341 taatttgagc tcttctggag gaatattccc attgcttgca gaatcagttt tgaagaatga
    11401 cggcgtagta ataggagctg cttgggacga taaatttaat gtcaaacata ttcttattaa
    11461 atcaaaaagt gaactgccat tattatgtgg ttcaaaatac atacagagta atacagaaaa
    11521 ggtcttcaag atagttaaag aacatctgtc tattcaaact gttcttttct caggaacacc
    11581 ttgtcaagtg aaaggactta aaacattttt gggaaaagat tatgataatt tgattacggt
    11641 cgaattggtt tgtcatggag ttccttcacc attggttttt agacggtatt tgaatggggt
    11701 tttgaaatat aataatttag atatttcaca gtgtagtaaa attaatttta gggaagtaaa
    11761 agatgatatc tatagatttg tgatatataa taagaccaaa ataccatttt atgaacaata
    11821 tacaaatctt tatactaaaa catttcttca aaatttattc ttacgtaatt cttgttataa
    11881 ctgtaaatgt aaattggaaa attccgtagg agattttatc ttaggagact tttggggatg
    11941 tagggatttc tatcctgaat tttatgatcc aaaaggagtt agcttagtta ttgtttgtac
    12001 tgaacgtgca aaaaaaatat ggttaaattt aaaattatca agaatagaag ttaagaaaaa
    12061 gattgttttt agaagtaata ggcatttatt aaaatctgca tcttataata gaaatagaga
    12121 cttgttcttt aaaactttta ttcatgaggc tgagatatca ctagatgata ttttgatggg
    12181 atacacaaat aaggatattt gggttaaggt taaaggtttg ataattagtg ttttacgttt
    12241 tgtggggctt ttccaattag ttcaattgta tagaaaatga aaatagcatt acttacttta
    12301 ccatttgtta ataattatgg aggaatatta caagcttatg ctttaaaaca ttttttagag
    12361 ttaagagggc atagtgtttg cattatagat agaaattcaa attttaaaat aagttttatt
    12421 gatatattac gtcttgcaaa aaggaagttt ctgggaaata gaattcgtaa ctttgcttat
    12481 tttaagaagc aatatttatt accaatgaca tctgagatta taactaataa agaaatgtta
    12541 ttgcttgatg aaaaatatca atttgatatt tatattgttg gtagtgacca ggtttggaga
    12601 gcaatatatt atagagatat taaatataat ttttatttgg attttgtgtc gagtaagagg
    12661 aagatatcct ttgccgcttc ttttggcata tcttcttggg aatatacaaa cactgaaact
    12721 gatattattg caaaactgtt aatggatttt tcttttgttt ctgttagaga agatacagca
    12781 gtaaggttat gttctgatta cttgaatatt aatgctgtgc aattcctaga tccaactttc
    12841 ttattggata aaaacgaata ttgttgtctt gctgattgtt tttatagttc taaaaagatt
    12901 gatatttttg cttatataat ggggcctgat tcatctaaag ataaattaat taaaataata
    12961 agcgattatt ctggcttgag tgttcaatct ataactcaaa gtaaattctc ttttaaaaag
    13021 aatgaaagta ttcaagaatg gctacaaaat ttttataagt cgaaatttgt tgtaacagac
    13081 tcttttcatg gtttagcttt ttctttaata tttaataaac cttttattgt ttgtggcttt
    13141 agtaatagag gaatggggag atatgaatct ttattgagat atttctcttt ggaaaataga
    13201 cttttatatt cattggaaga tttaaaagaa ctaaatttat ctactatttg ggatataaat
    13261 tggaaggaag ttaatgctaa aattgctgag aataaaaggt ttgtattgga gttaatgcag
    13321 acggtaggtg tataatgtca cttaaagaaa atacaattta tggtgtactg tggagttcat
    13381 ttgagaaatt tggaacttta tcgatacaat ttatttacat gattgtgatg gcaagattgc
    13441 tatctccttc tgattttggt atagttggca tgttgacaat ttttatttct gtaggccaag
    13501 ttatacttga tagtggtttt ggacaggctt taataagatt acaaaaatat gatgatttac
    13561 atttttcttc aatttttata attaatgtta ttatgggagt tctactctat ggaatattat
    13621 tttatatggc tccatatatt tctttattct atagagaacc tagcttaaca ttaatttcaa
    13681 gaatatcttt tttgattttt cccatcaatt cactaagtat agtccaatat actttattag
    13741 tgaaaaaaat ggattttaaa tctatttcta aaatatcttt attctcgata attttatcta
    13801 caatttcagg tattacatat gggtattttt accctaatat atttgcacta ttaattcaaa
    13861 atgtctcatt ttatttttat aggctacttt tattatggta ttatggaaac tggaaattat
    13921 catgtcgaat ttcatggagt aaattacaag atttgatgcc attctctttt acgttattag
    13981 ctacaggctt tatttctact gtcgtaggag agttgtattc attgtctatt ggtaagttct
    14041 tttcttcatc tgttttaggt ttatattctc aagcagaaag gttttcgaaa attccatctt
    14101 tttctataac agatgttgtt caacgtgtga cttatcctgc attatcagtg ttacaagacg
    14161 atgatcaaaa attaaagcat tcatatagaa tggttattat gtgcacattc tttatagtat
    14221 tgcctgtaat gctttttctt tttattagcg ctggcgaaat ttttgaatta ttatttactg
    14281 aaaaatggga acagg
//
