LOCUS       c00081_gnlPro..        13494 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BLIPJLBC_81.
ACCESSION   c00081_gnlPro..
VERSION     c00081_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 22:37:43
            Original ID  :: gnl|Prokka|BLIPJLBC_81
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13494
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13494
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1:3494]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2..3494
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..13494
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13494
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             2..685
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg81_1"
                     /sec_met_domain="SucD_FumR (E-value: 1.7e-131, bitscore:
                     425.6, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VGRKVVMSVTGIALVLFLTFHMAMNLVAIISADGYNMICEFLGAN
                     WYALVATAALAALFIIHIIYAFWLTMQNRTARGSERYAVVDKPKTVEWASQNMLVLGII
                     VIVGLGLHLFNFWAKMQLPELMHNLDMHADTLTLAYAANGAYHIQQTFSCPVYVVLYLI
                     WLFALWFHLTHGFWSSMQSLGWNNKVWINRWKCISNIYSTIVVLGFALVVVVFFVKSLL
                     CGGAC"
     CDS             723..2702
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 202.3; E-value:
                     4.6e-62)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg81_2"
                     /sec_met_domain="FAD_binding_2 (E-value: 1.1e-62, bitscore:
                     202.3, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 1.2e-37,
                     bitscore: 118.8, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKIDSKIPEGPVAEKWTNYKAHQKLVNPANKRRLDIIVVGTGLA
                     GASAAASLGEMGFRVFNFCIQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTVKG
                     GDYRAREANVYRLAEVSNAIIDQCVAQGVPFAREYGGTLDNRSFGGAQVSRTFYAKGQT
                     GQQLLLGAYSALSRQVNVGTVKLYTRYEMQDVVIVDGRARGIIAKNLVTGELERFAAHA
                     VVIATGGYGNAYFLSTNAMGCNCTAAISCYRKGAVFANPAYVQIHPTCIPVHGDKQSKL
                     TLMSESLRNDGRIWVPKKKEDAVKLQKGEIKGSDIPEEDRDYYLERRYPAFGNLVPRDV
                     ASRAAKERCDAGFGVNNTGLAVFLDFSEAINRLGIDVVLQRYGNLFDMYEEITDVNPGE
                     LAKEISGVKYYNPMMIYPAIHYTMGGIWVDYELQTTIKGLFAIGECNFSDHGANRLGAS
                     ALMQGLADGYFVLPYTIQNYLADQITVPRFSTDLPEFAEAEKAVQAKIDKFMSIQGKES
                     VDSIHKKLGHVMWEYVGMGRTAEGLKKGIAELKEIRKEFETNLFIPGSKEGMNVELDKA
                     IRLYDFITMGELVAYDALNRNESCGGHFREEYQTEEGEAKRDDENFFYVACWEYQGDDE
                     KAPVLHKEPLVYEAIKVQTRNYKS"
     CDS             2739..3494
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg81_3"
                     /sec_met_domain="Fer4_7 (E-value: 1.1e-12, bitscore: 38.5,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer2_3 (E-value: 7.9e-26, bitscore: 80.3,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 4.8e-07, bitscore: 20.2,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKNISFTLKVWRQAGPKAKGAFETYQMKDIPGDTSFLEMLDILN
                     EQLISERKEPVVFDHDCREGICGMCSLYINGHPHGPATGATTCQIYMRRFNDGDTITVE
                     PWRSAGFPVIKDLMVDRTAYDKIMQAGGYVSVRTGAPQDANAILIPKPIADEAMDAASC
                     IGCGACVAACKNGSAMLFVSAKVSQLNLLPQGKPEALRRAKAMLSKMDELGFGNCTNTR
                     ACEAECPKNISISNIARLNRDFIIAKLKD"
     CDS             3655..4884
                     /locus_tag="ctg81_4"
                     /transl_table=11
                     /translation="MNKLLLIWIVVLLTSCITNQENARDTLFVNLTDATDSQSLKLSDF
                     GNTVRYVPLETNEVCLIGNNPHIALLEDKIVIATKDQCFLFHKQTGKYICSIGHIGDDP
                     SGYSSTNYWIDDAGLFYFFRAPDQLLKYNQKGEMTGKIQIPHIPAAPDFFAFSDSTIIA
                     HCNSSIGLESSNSLLFLNSFGEKLDSIPNLLKSPSIPSPDNISSLSIIKRGAGFFGNLG
                     RRGVMIIKDKEQGELLLPLYNPSLWSSENEVRFRETFTDTIYTIKNRKLYPYMVFHTDT
                     DHSSANPLWYSNPQSIYVAYVLENTHSVFFQYVKNKQVYNGLYNKETQQTKFAKCQQFI
                     VDDLTSEQELKVDLSALCSYKGEYGFILEAASIPDASQKQSDNKNENIPHWMSQLDEDA
                     NPVIAIVSDK"
     CDS             complement(4956..6482)
                     /locus_tag="ctg81_5"
                     /transl_table=11
                     /translation="MRTKRAFKEFCVLGGLASSVCGVAQERPNIIVFLVDDMGLMDTSV
                     PFIADESGQPVRHPLNDWYHTPNMERLAKQGICFSTFYAQSVSSPSRASIMTGQNATRH
                     GVTNWINAESNNRNPFGPPQWNWKGLRKDMPTMPRVLQQAGYKTIHVGKAHFGCMGSEG
                     ENPLNIGFDVNIAGSGIGHPGSYYGEWGYGHIKGQKIRAVPDLEKYHGTDTFLSEALTI
                     EANREITKAVEEKRPFYLNMAHYAVHSPFQADKRFLSRYTDPDKNEQARAFATLIEGMD
                     KSLGDIMDQLEKLGIAENTLILFLGDNGGDAPLGDERGYGSSAPLRGKKGTEFEGGMRV
                     PFIAAWAKPEKKSKVQKNLPIEVGSMQTQLGTIMDIYPTVLSVAGCEVPQNYVIDGFDL
                     KKQLSGKVDKKRPESFLMHFPHAHRGSYFTTYRMGDWKLIYYYLPETPKQPKALLYNLK
                     DDPEERNELSAAHPDQCREMIREMSARLEKEGALYPVDKQGNELKPFVYF"
     CDS             complement(6717..7559)
                     /locus_tag="ctg81_6"
                     /transl_table=11
                     /translation="MSSICQGTWDCQNCPKAVDNAIAHVIHPRGYHQPVRKCEENFILF
                     LIRGEVLVNSQEYAGTMLRAGEFILQAIGSKFEMLAMTECECIYYRFIQPELFCDFRFN
                     HIMKEVSSPLIYSPLKIIPELKYFLDGSKSYLSESKVCRDLLSLKRKELAFVLGYYYSD
                     YDLASLVHPLSKYTSTFQYFILQNYKKVKTVEELAQLGGYTVSTLRRIFNNVFHEPVYE
                     WMQARRKEGILDELLNTNNSISEICYKYGFESLPHFSNFCKKFFGASPRMLRTNKKTI"
     CDS             complement(7758..8732)
                     /locus_tag="ctg81_7"
                     /transl_table=11
                     /translation="MKKILLAIAAVATITGCSQSEEFENPGQKAEINFSTAVTRATALD
                     TEGLQNAGFQVYAYNTGTTEMSTTAVLPSSAWIANKATYASTWSVAGGPYYWPLDENLQ
                     FFAYSPSDGVTYTGPDGTIAGYPKFTYKVGDTAADQKDLVISSVLNQTKETDKTAPVVS
                     LNFKHALTQINVQVIKGSTDYTYEFAADNAVTISGIKGEGTFAYTGADTGDWTPEGTEA
                     TYTYTLGDFTDGTSAIVPGNALMLIPQDITDAKITIRYNTKKGDSYIFKGSKEIPLKST
                     TAWAFGTKILYKLTLPVGGEEVKIEATAAKWDTEKPETTEPSV"
     CDS             complement(8783..9745)
                     /locus_tag="ctg81_8"
                     /transl_table=11
                     /translation="MQDTRYILLVLLSSLLMLTGCSRRELLDDYPVSGVDIKLDWNGVT
                     DKLPEGVRVIFYPKSAEGRKIDTYLSVRGGKVKVPPGRYSVVAYNYDTETVQIRGEEAY
                     ETIEAFTGYCNGLGIAGTEKMVWGPDPLYVVQIDDLHIANSEEELLLDWKPKLVVKTYF
                     FKIKVEGLEYVSSIVGSVEGMAGCYCLGRCCGMMCDAPIYFEAQGRSGEVTGSFTAFGM
                     PEAAISRAGDKIKLTLAFIKVDKTVQKAEIDITEVVTNSESGGSGGGNVDEPPTEIELP
                     LDEKVKVEKPTTNPDGGGGGIGGDVGDWGDEDEVVLPVE"
     CDS             complement(9753..11030)
                     /locus_tag="ctg81_9"
                     /transl_table=11
                     /translation="MKHGIYTCVILMAFLALSESVYAVVPVFTIASDTIRRVVIYFDQE
                     ETDVDSCYKTNNQEINVLDSLLEERINSRYITALNVVTFVSPDGDSVYNAALSVRRNNS
                     MREFLRQRYPYVDVEKIKLTSEGEDWSELRKLVASDSDLPDREEVLMLIDYHRDNIVKR
                     KELLQKLNQGMAYRYIVRNVLPKLRRAEITVVRKVPEMEKNIFEPVSSVSGLFVSKQEE
                     ALPSDQPDKPEGESKESMAYEVVVSEAEGPVESKTVLAVKNNLLYDLALAPNLEVEIPV
                     GKRWSLNAEYKCPWWLNSKHDFCYQLLSGGVEGRCWLGNRQKRNRLTGHFVGLYAEGGI
                     YDFQWKGDGYRGDYYGAAGVTYGYARQLARHLSLEFSFGIGYLTTEYKKYTPYEGDIVW
                     TTSGRYNFIGPTKAKVSLVWLIKRGR"
     CDS             complement(11302..11799)
                     /locus_tag="ctg81_10"
                     /transl_table=11
                     /translation="MALEYVVTKRVFGFDKDKNEKYVAKSVRSGRVSFSKMCGKVSRLC
                     GVHRKVVDLVVSGLVDMMAEDIDDGKSVQMGEFGIFSPTIRAKSADDEKEVSSKSIVQR
                     KILFYPGKIFKTTLDDMSITRRAELDTDYTDGSSNNGSGSVKPNPGGDGGKGDEEAPDP
                     TV"
     CDS             complement(12160..12285)
                     /locus_tag="ctg81_11"
                     /transl_table=11
                     /translation="MRKHTFLFIIFLYVGICIQVKATDQRGEYLVIGKDTLEMFT"
     CDS             complement(12759..12980)
                     /locus_tag="ctg81_12"
                     /transl_table=11
                     /translation="MRGILSFAALAAMYFPGCTTSKNAVHCLSRWIKGCNPLVKELIPT
                     GYLPYNHRFLTSKQYKIITKHLGDPYED"
ORIGIN
        1 tgtaggaagg aaagtggtga tgagcgttac cggtatcgcc cttgtcctgt ttctaacatt
       61 tcacatggcg atgaacttag ttgcaatcat ctcggctgat ggttacaaca tgatttgtga
      121 gtttttggga gcaaactggt atgcgctggt agctaccgca gcactggctg ctcttttcat
      181 tattcacatc atctacgcgt tctggctgac aatgcagaat cgcacagcgc gcggtagcga
      241 acgctatgca gtagtcgaca aaccgaaaac tgtagagtgg gcttctcaaa acatgttggt
      301 gttaggcatt atcgttatcg taggcctcgg tttgcacctc ttcaacttct gggcaaaaat
      361 gcagttgccg gaactgatgc acaacctgga catgcacgct gatacactga cgctggctta
      421 tgcggcaaac ggtgcatatc acatccagca gacattctct tgtccggttt atgtagtgct
      481 ctacctcatt tggctgtttg ctctgtggtt ccacctgact cacggtttct ggagctccat
      541 gcaatcactg ggatggaaca acaaggtatg gatcaatcgt tggaaatgta tttctaacat
      601 ctattctacg attgtagtac tcggtttcgc actcgtagta gtggtattct tcgtgaaatc
      661 actcctttgt ggcggtgctt gctaaatagt aaattgtaaa tgattaaatt gtaaataata
      721 ttatgatcaa gatagattca aaaattccag aaggcccggt ggctgagaaa tggaccaact
      781 ataaagctca ccagaaattg gtgaatcccg ctaataaacg tcgtttggac atcatcgttg
      841 tgggtacagg tctggcaggt gcttctgccg ctgcttcact cggtgaaatg ggtttcagag
      901 tattcaattt ctgtattcag gattcccccc gtcgtgcaca ctctatcgct gcacagggtg
      961 gtatcaatgc tgcaaagaat tatcaaaatg acggtgactc cgtttaccgt ctgttctacg
     1021 atactgtaaa aggtggtgac tatcgtgccc gtgaagctaa cgtatatcgt ctagctgaag
     1081 tgtctaacgc tatcatcgac caatgtgtag cacaaggtgt tcctttcgct cgcgaatatg
     1141 gtggtacact ggacaaccgt tctttcggtg gtgcacaggt atcccgtact ttctacgcta
     1201 aaggccagac tggtcagcag ttgttgctgg gtgcttactc tgcattgagc cgtcaggtaa
     1261 acgtaggtac tgtaaaactg tacactcgtt atgaaatgca agatgtggtg atcgttgacg
     1321 gacgtgctcg cggtatcatc gctaaaaatc ttgtaacagg tgaactggaa cgcttcgccg
     1381 ctcacgcagt agttatcgct accggtggtt atggtaacgc ttacttcttg tctaccaacg
     1441 ctatgggttg taactgtaca gctgctatct cttgctaccg caagggtgct gtattcgcta
     1501 accctgcata cgttcagatt cacccgactt gtatcccggt acacggtgac aagcagtcta
     1561 aactgacttt gatgtctgaa tctctccgta acgacggtcg tatctgggtt ccgaagaaaa
     1621 aagaagatgc tgtgaaactt cagaaaggcg aaatcaaagg aagtgatatt cctgaagaag
     1681 accgcgacta ttacttggaa cgccgctatc cggcattcgg taacctggtt ccgcgtgacg
     1741 ttgccagccg tgccgctaaa gaacgttgcg acgcaggttt cggtgtaaac aacacaggtt
     1801 tggccgtatt cctcgacttc tctgaagcta tcaaccgttt gggtatcgac gttgttcttc
     1861 aacgttatgg taacctcttc gatatgtacg aagaaatcac tgacgttaat ccgggcgaac
     1921 tggctaaaga aatcagtggt gtgaaatatt ataacccgat gatgatttat ccggctatcc
     1981 actatacaat gggtggtatc tgggtagact acgaactgca aaccactatc aagggtctgt
     2041 tcgctatcgg tgaatgtaac ttctccgacc acggtgcaaa ccgcctcggt gcttctgcat
     2101 tgatgcaagg tttggctgac ggttacttcg tattgcctta cactatccag aactatctgg
     2161 cagatcagat cactgttcct cgtttctcta ccgatcttcc tgaatttgct gaagctgaaa
     2221 aagctgttca agctaagatc gacaagttca tgagcatcca gggtaaagaa tctgttgatt
     2281 ctatccacaa gaaactgggt catgtcatgt gggaatatgt aggtatggga cgtacggcag
     2341 aaggcctgaa gaaaggtatc gccgaactga aagaaatccg caaggaattc gaaacgaact
     2401 tgtttatccc cggttctaag gaaggtatga acgtagagct tgacaaagca atccgtctgt
     2461 acgacttcat cactatgggt gagcttgttg cttacgacgc attgaaccgt aacgaaagtt
     2521 gtggtggtca cttccgtgaa gaataccaga ctgaagaagg agaagcaaaa cgtgatgacg
     2581 agaacttctt ctatgtagca tgctgggaat atcaaggtga tgatgaaaag gctccggtat
     2641 tgcacaaaga accgctggta tacgaagcta tcaaggttca gactcgtaac tacaagagct
     2701 aatcggtgaa gttaaacatt taaaagaatt agaagaaaat ggataaaaat atatcattta
     2761 cactgaaggt atggcgccaa gctggtccga aagctaaagg tgcttttgaa acctaccaaa
     2821 tgaaagatat ccccggtgat acttccttcc tcgaaatgct ggatattctg aacgaacagc
     2881 tgatcagcga aagaaaagaa ccggttgtat tcgaccacga ctgccgcgaa ggtatctgcg
     2941 gtatgtgttc tctttacatc aacggacatc cgcacggtcc tgcaacaggt gctactactt
     3001 gccagattta catgcgtcgt ttcaacgatg gtgacaccat cactgttgag ccttggcgtt
     3061 cggccggttt ccctgtcatc aaggacttga tggtagaccg tactgcttat gacaagatca
     3121 tgcaggccgg tggttacgta agcgttcgta caggtgctcc gcaggatgcc aacgctatcc
     3181 tgatcccgaa gcccatcgct gacgaagcta tggatgccgc ttcttgtatc ggttgcggtg
     3241 cttgtgtagc tgcttgtaag aatggttctg ccatgttgtt cgtttcggca aaggtcagcc
     3301 agttgaactt gcttccgcaa ggtaaaccgg aagctctacg ccgtgcgaaa gctatgttgt
     3361 ccaagatgga cgaactcgga ttcggtaact gtaccaacac ccgcgcttgc gaggctgaat
     3421 gtccgaagaa catctctatc agcaacatcg cccgcctgaa ccgcgacttc atcatcgcta
     3481 aactgaaaga ctaagcgtga gcttgatttg attaatagca taaatccccc gtcggcgtta
     3541 gctggcgggg gatttctttt tactgaccaa ttatttatag atagcttgtt cattatccgt
     3601 tttttattct tttctttgtg acataaggcc agacaatcaa ataaattaaa tacgatgaat
     3661 aaattattgc tgatatggat agtagtctta ctaacctcat gcatcacaaa tcaggagaat
     3721 gccagggata cattatttgt aaatcttacg gatgcaactg attcccaaag cctaaagtta
     3781 tctgacttcg gaaatactgt acgttatgta cctttggaaa ccaacgaagt atgcctgata
     3841 ggaaacaatc cccatatagc gctgctggaa gacaagattg tgattgctac taaagaccaa
     3901 tgtttcttat tccacaaaca gaccgggaag tatatatgca gtataggcca tatcggtgat
     3961 gatccaagtg gatatagctc gacaaattac tggatagatg atgcaggtct tttttacttc
     4021 tttcgcgcac cggaccagtt gctaaaatat aatcagaaag gagaaatgac cgggaaaatt
     4081 caaattccac atatacctgc cgcacccgac tttttcgcgt tttccgactc taccattatt
     4141 gcccattgta atagtagtat aggattggaa tccagcaact ctttgctttt cctcaactcc
     4201 tttggagaaa agctggattc aattcccaat ttattaaaat cgccctctat cccttctccg
     4261 gataatatat ccagcctttc tatcataaaa agaggagcag gtttctttgg aaatctggga
     4321 agaagagggg taatgattat caaagataag gagcaaggag aattactgct gcctctctat
     4381 aatcccagcc tatggtcgtc cgagaatgaa gtacgtttca gagaaacctt cacagacacg
     4441 atatacacaa ttaaaaacag gaaactatat ccatatatgg tttttcatac agatacagat
     4501 cattcatccg ccaatccttt atggtatagt aatccgcaaa gtatctacgt agcttatgta
     4561 ttggaaaaca cacattctgt attttttcaa tacgtaaaaa acaaacaagt ctataatggt
     4621 ttgtataata aagaaacaca gcaaactaag tttgcaaagt gccagcaatt cattgttgac
     4681 gatctcactt cagagcagga actgaaagtt gacctgtcag cattgtgcag ttataaagga
     4741 gaatatggat ttattctgga agctgccagt attcctgatg cttctcaaaa acaatctgac
     4801 aataaaaatg agaatattcc ccattggatg agccaattgg atgaggatgc caatccggtc
     4861 atagcaattg tatctgacaa atgatatata attctgtctg ttttgcctaa tagatatgct
     4921 ttggcaaaac agacagttga aatagtagca cctatttaaa agtaaacaaa aggcttcaac
     4981 tcatttcctt gtttatccac cggataaaga gctccttcct tttctagccg ggcggacatt
     5041 tcccgaatca tctctctgca ttgatccgga tgtgcggcag acagctcatt cctttcttcc
     5101 ggatcgtctt tcagattgta aagcaaggct ttgggttgtt tcggagtctc gggaagataa
     5161 taataaatca gtttccagtc gcccatgcga taggtggtga agtagctgcc gcggtgtgcg
     5221 tgagggaagt gcatcaggaa agactcggga cgcttcttgt ccaccttacc gctcagttgc
     5281 tttttcagat cgaatccgtc tatcacgtag ttttggggaa cttcgcatcc tgccacagac
     5341 agaacagtcg gatagatatc catgattgtg cccaactgtg tctgcatact tcctacttca
     5401 ataggcaagt tcttctgtac tttgctcttc ttctcaggct tggcccaagc tgcgatgaaa
     5461 ggaacacgca taccaccttc aaactccgtc ccctttttac ctctcagcgg agcggaagaa
     5521 ccatagccac gttcatctcc caatggagca tcaccaccgt tatctcctaa aaagagaatc
     5581 agcgtatttt cggcaattcc cagcttttcg agttggtcca tgatgtcgcc taatgattta
     5641 tccatgcctt ctatcaatgt agcaaaagct cttgcctgct cgttcttatc cgggtcggtg
     5701 tagcgtgaca agaaacgttt gtctgcctgg aaaggtgaat gaactgcgta atgggccata
     5761 ttcagataga aaggtcgttt ttcttctacg gctttggtga tctcccgatt cgcttctata
     5821 gtcagcgctt cactcaggaa ggtatctgta ccgtgatatt tctccaggtc aggaactgct
     5881 ctaatcttct gtcccttgat atgcccgtat ccccattcgc cataatagct gccgggatgt
     5941 ccaatgccgg aacctgcgat atttacatca aagccgatat tcagcggatt ctctccttcg
     6001 cttcccatac agccgaaatg tgcttttcct acatgaatgg ttttatatcc ggcttgttgc
     6061 aggactctcg gcatggtagg catatctttt ctgagacctt tccagttcca ttggggcggt
     6121 ccgaaaggat tccggttgtt gctctcagca ttaatccagt tagtgactcc atgcctggtc
     6181 gcattctgtc cggtcatgat ggaagctctg gaaggggaac tcacgctctg tgcgtaaaaa
     6241 gtagagaaac aaataccctg tttagccagt ctctccatat tcggagtatg ataccagtca
     6301 ttcagcggat gacgcaccgg ctgaccactc tcatctgcga taaaaggaac cgacgtatcc
     6361 ataagtccca tgtcatctac aaggaagaca ataatattcg ggcgttcctg agccaccccg
     6421 caaacggaag atgccaaacc acccaataca caaaattcct taaaagctcg ttttgttctc
     6481 attacatagt atttatgatt tatatcctag ttattgtacg tgtcgcaata gatttaaatt
     6541 tactgaaata aaaagtttaa tttccgtatc cgccttgtca tggctttatt tgaagtgatc
     6601 cgactctata ataaagatgt attagactga ttttaaggga aacagcagca atatacaaca
     6661 aatgcactat gctcacaaag aaaaaaagat tatttgacgt tctctctgaa aaattatcag
     6721 atggtctttt tgtttgttct tagcatgcgt ggagaagcac cgaagaattt cttacagaaa
     6781 ttggagaagt gtggcagaga ttcaaagcca tatttatagc atatttcaga gatactgttg
     6841 tttgtattaa gcaactcgtc caaaatacct tccttacgtc gcgcctgcat ccattcgtat
     6901 accggttcgt ggaatacatt attgaagata cgccgcaggg tactgacagt atagccgcca
     6961 agttgggcaa gttcttccac tgtttttact ttcttatagt tttgaaggat gaagtactgg
     7021 aaagtggaag tgtatttaga gagtggatgt accaagcttg ccaaatcata gtctgaataa
     7081 tagtacccca atacaaatgc cagttccttg cgctttaacg acagcaagtc ccgacaaact
     7141 ttactttcac tcaaatagga tttagagcca tccaaaaaat atttcaattc agggattatc
     7201 tttaatggtg aatagattaa tggtgaagac acctccttca taatatgatt gaaacggaag
     7261 tcacagaata gttccggctg aatgaaacga taataaatac attcgcactc agtcatggca
     7321 agcatctcaa attttgaacc gatagcctga agaataaatt cacctgctct cagcatcgta
     7381 cctgcatatt cttgactatt aaccaatacc tcacctctta tcaaaaaaag gatgaagttt
     7441 tcctcacatt tccggactgg ttggtgatag cctcttggat gaataacgtg agcaatagca
     7501 ttgtctacgg ctttcgggca gttctgacaa tcccaagtac cttgacagat agatgacata
     7561 tatttgtgtt ggtgtttgat ttgttcctgt tggccaacaa atgtatatga aatcttttat
     7621 atgacaatga gaaagggaag aaatttataa aatcactctc gttgcaatat gtcgtaacga
     7681 gaatgatctt ataaattcaa aactacataa actggtataa aagactataa cctgagaaat
     7741 attattctat taatacatta aacgctaggt tcggtagttt caggcttttc agtatcccat
     7801 ttagcagctg tcgcttcgat ctttacttct tcaccaccaa ccggtaaagt cagcttatac
     7861 aaaattttag ttccaaaagc ccatgctgtg gtagacttca aaggaatctc ttttgatcct
     7921 ttaaatatat agctatcgcc cttctttgtg ttatacctaa tcgttatttt agcatcagta
     7981 atatcttgtg gtatcaacat cagtgcatta ccaggaacaa tggcacttgt cccgtcagta
     8041 aaatcaccta aagtatatgt atacgtcgct tcagtgcctt ctggcgtcca atcgccagtg
     8101 tcagctcctg tataagcaaa ggttccttcg cctttaatgc cacttattgt aacagcatta
     8161 tcagctgcaa attcgtaggt ataatctgta cttcctttaa tcacctgaac attaatttga
     8221 gtcaatgcat gtttaaaatt taacgaaaca actggtgctg ttttatccgt ttccttagtc
     8281 tgattcaaca cggacgaaat aactaagtct ttttgatcgg cagccgtatc ccctacttta
     8341 taagtaaatt taggatatcc cgcaatagta ccatcaggac cagtatatgt aactccatct
     8401 gacggagaat aagcaaaaaa ctgtaaattt tcatctaatg gccagtaata cggacctcct
     8461 gctactgacc aagtactagc ataagttgcc ttattagcta tccatgctga agacggaaga
     8521 accgcagtag tagacatttc tgtcgttcct gtattatatg cataaacctg gaaaccagca
     8581 ttttgtaaac cttctgtatc aagtgcagtt gctctagtta ctgctgtact aaaattaatt
     8641 tccgcctttt gtcccggatt ctcaaactct tcactctgtg aacaacctgt aattgttgca
     8701 actgctgcaa tagccaataa aatctttttc ataattgtat tttttaattc gttaatattg
     8761 ttatatttgt ttatgtttaa tctcactcaa caggcagaac cacttcatcc tcatcgcccc
     8821 aatcaccaac atctccacca ataccaccac ctccgccatc cggattagta gtcggcttct
     8881 caaccttaac cttttcatca agtggcaact ctatttccgt gggaggttca tcaacatttc
     8941 ctcctccact acctccactc tcagaattag taaccacctc cgttatatca atctccgctt
     9001 tctgcacggt tttatctact ttaataaaag ccagtgtcag ctttatcttg tcacctgccc
     9061 ggcttatcgc ggcctccggc attccaaaag cagtaaaact acccgttact tcacccgaac
     9121 gcccttgcgc ctcaaagtaa ataggagcat cgcacatcat cccgcaacat ctgcccaaac
     9181 agtaacaacc cgccatacct tccacactgc ctacaattga agaaacatat tccagtcctt
     9241 ccaccttgat cttgaaaaaa taggtcttta ccactaattt cggtttccaa tccagtagaa
     9301 gctcttcttc actgttcgct atatgtaaat catcgatctg cactacgtat aagggatcag
     9361 gtccccatac cattttctcc gttcccgcta ttcccagacc attgcaatag cctgtaaatg
     9421 cttcaatcgt ctcataggct tcctctcctc tgatctgcac cgtttcagtg tcgtagttgt
     9481 aagccactac cgagtaacgc cccggcggca cctttacttt tccacctctt actgaaaggt
     9541 atgtatcaat ctttctgcct tccgcactct tcggataaaa aatcacccga accccttccg
     9601 gcaacttatc ggtaacaccg ttccaatcta actttatatc taccccgctt acgggataat
     9661 catccaatag ttcgcgacgg ctacatccgg tcagcatcag cagcgaggac agaagcacaa
     9721 gaagtatgta tcttgtatct tgcataacgt ccttatctcc ctctttttat cagccatacc
     9781 agagagactt tcgccttggt aggacctata aagttataac gtccactagt tgtccacacg
     9841 atatccccct cgtaaggagt atatttctta tattctgttg tcagataccc gatgccgaag
     9901 ctaaattcga gcgacagatg gcgagccagt tgccgcgcat acccgtaggt cactcccgca
     9961 gctccgtaat aatcgccccg gtaaccgtcg cccttccact ggaaatcgta aattccacct
    10021 tcagcataaa gcccaacaaa atgccctgtc aaccggttgc gcttctgacg attgcccaac
    10081 cagcaacgtc cttccactcc tcccgaaaga agctgataac agaaatcatg tttactgttc
    10141 agccaccacg gacatttgta ttcagcattt aaagaccacc ttttgcctac cggaatctct
    10201 acttccagat ttggcgccaa cgccaaatcg tacaacagat tattcttcac tgcaagcacc
    10261 gttttacttt caaccggccc ttctgcctcc gacactacca cctcataagc catactctct
    10321 ttactttctc cctccggctt atcaggttga tcgctcggaa gcgcctcttc ctgctttgaa
    10381 acaaacaatc cggagacaga agataccggt tcaaaaatat tcttttccat ttccggaact
    10441 ttgcggacaa ccgtaatctc agcgcgtctc aacttaggta acacgttgcg gacaatatat
    10501 cggtaagcca ttccctgatt caacttctgc aacagttctt ttcgcttcac gatgttatcc
    10561 cgatgataat ctatcaacat caagacttct tcccggtccg gcaagtctga atccgacgcc
    10621 accaacttac gaagttcaga ccagtcttct ccttcagaag taagtttaat cttttcgaca
    10681 tcaacatacg gataacgttg ccttaagaac tctctcatcg aattgtttct tcggacagat
    10741 aatgcggcat tgtaaaccga atctccgtca ggcgatacaa aagtgaccac attgagcgca
    10801 gtgatatatc ttgaatttat tctttcctca agcaaagaat ctaaaacatt aatttcttga
    10861 ttattagttt tataacagga atcaacatct gtttcttcct gatcgaaata tatcaccacc
    10921 cgcctgatag tgtcactcgc aatcgtgaaa accggaacca ctgcatacac actttctgat
    10981 aaagcaagaa atgccatgag aataacgcat gtatagattc cgtgtttcat aattgttcgt
    11041 ttctgtgaac aaatatagaa gttataatat aaactaaatc atactagcag aacaaaaaac
    11101 aggacatgga aggttctgtg aaacgattgg aacgaatttg caagtttaga agcaaataag
    11161 gaggaaacaa tagatacacc aaggcattat ataaagaaaa aatgcacaga aaatcgagta
    11221 taaccgatta tctgtgcatt tgcaactttt caataagcct ttcccacgct gtctgctacc
    11281 taaaaagaaa gtacagaaga tttatacagt cgggtccggc gcttcttcat caccctttcc
    11341 tccgtctcca ccgggattag gttttacgct accgctgcca ttgttactac ttccgtccgt
    11401 atagtccgta tccaactccg cacgacgggt aatactcata tcatccaacg tggtcttgaa
    11461 tatttttcca ggatagaaaa ggatctttct ttggacgatt gacttagatg atacttcctt
    11521 ctcgtcatcc gcactcttag cgcgaatggt agggctgaag atgccgaact cacccatctg
    11581 aacactcttt ccgtcgtcaa tgtcctccgc catcatatcg acaagaccgc tgacgaccag
    11641 atccacaact ttgcggtgaa ctccacaaag acggctcacc ttgccacaca tcttggaaaa
    11701 acttactctg ccggaacgaa ccgactttgc tacatacttt tcgtttttgt ccttgtcaaa
    11761 accgaacact ctttttgtta ctacatactc taaagccata attgttaaag tttaaatggt
    11821 taaaaaaata aaggttatct gtttgccatt ccgttttgtc tgaatgactc tgcaaagata
    11881 taacagggcg caaaccgtcc agtccccttt agtccccctt gtgtctcctt tcaatggctt
    11941 taaagcagta aatatcctaa agtaattcgc ttattttcaa tcgactatac agatgaatat
    12001 tttttttcca aagtgcgttc attgctgttt ctccaaatag agtctgtcgg tttccagtct
    12061 ccatataccg acataccccc gcccgcaatc agtagagaag gagcgcttcg aaatacaatt
    12121 ctttacctgc ttactcagag tctcactatc tcccaatggt caagtaaaca tttccaatgt
    12181 atctttacct atgacgagat attcccctct ttgatctgtt gccttaacct gtatgcagat
    12241 gccaacatac aaaaagataa taaatagaaa agtgtgcttt ctcatagctt tataatttta
    12301 gaaaaccgaa tatacatata tataatagag caataatact catttcggta tttatcatat
    12361 gcgaataaac gaattattct gtttgctcaa atagaattac gtacaaatta gctgcattat
    12421 agtataacca acgaaaaagc aacatgatac tttgtcatac aaaacggtct atgagagaaa
    12481 ggtaaaaata gtcatgcaaa tttaccaata tactaatcca atgaatacga tactgccttc
    12541 tcccgattta cccacaatga aaaacataga cactgtatac taaaaccgta tttgagtttc
    12601 taataaattc tttcatcgtt tattagaaac ggttcccaag tttattaaaa acaccgatac
    12661 gcctttcaaa tctctttttc ttgaatttat gcaacaagaa aggctgcaaa ctccgtaaaa
    12721 gtttgcagcc ttttgctcat tgccgggcta cttatgccct aatcctcata aggatctcct
    12781 agatgttttg ttatgatctt atactgtttt gatgtcaaaa accgatgatt gtacggcaag
    12841 taacctgtcg gtataagttc tttgaccaac gggttacaac ctttaatcca tcggctgaga
    12901 caatgcaccg catttttact cgttgtacat ccggggaagt acatcgcagc cagtgcagca
    12961 aaagataaga ttcctctcat tcgtttctaa gttttgattt gaattttatt gttgttatta
    13021 cgactacaaa tatacaacat aaaaaagcct ttgtcaagtc ctcaagacct tcgagcgtta
    13081 ataacaaatt aaagaactgg agtactggca cataagcaag gattgcatcg tcaatgacta
    13141 acaagtttgt tactaacaac tttgttagta acaaacttgt tagttaataa aaaggctgag
    13201 attcctcaat tcagacccat tgtgtgcgat aacagtgaaa atccgtgaaa gaaatcaaaa
    13261 gagacgcaaa tacaagaata ttatttggaa ggaatagcaa gaagacttac atttgtcatg
    13321 tgattttttt catagtatta gatttaaggt taacaaaggt tggagcaagg cgttgctcct
    13381 ttttttatgc cccaaccttt ctttatttta cctcagagat ttattactgt cattccagta
    13441 ctgtcattga ctattttttc ggctttccac agatataaac cttgcattgg taag
//
