LOCUS       c00045_gnlPro..        13726 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JEFMIMID_45.
ACCESSION   c00045_gnlPro..
VERSION     c00045_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 22:14:33
            Original ID  :: gnl|Prokka|JEFMIMID_45
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 109300
            Orig. end    :: 123026
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13726
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[119300:122687]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13387
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..13726
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13726
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="2"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             227..361
                     /locus_tag="ctg45_82"
                     /transl_table=11
                     /translation="MIYDFTIDVRVEVRVRENIIERVPSIVNRKLSNRQSFLILSTFN"
     CDS             366..2615
                     /locus_tag="ctg45_83"
                     /transl_table=11
                     /translation="MKRLLLTYTLAVFLLPAFAGGGEKLSPVDYVNPFIGTTNFGTTNP
                     GAVCPNGMMSVVPFNVMGSADNKYDKDARWWSTPYEYHNCFFTGYSHVNLSGVGCPELG
                     SLLLMPTTGELNVDYKEYGSRYKDEQASPGYYTNYLTKYNVKTEVTATPRTGVTRFTFP
                     EGKSHILLNLGEGLTNESGAMLRRVNAQEIEGVKLLGTFCYNPQAVFPIYFVMRVNKLP
                     SQTGYWKKQRPMTGVEAEWDPDNGKYKLYTKYGKEIAGDDIGAFFSFDTEDGEQVEVEM
                     GVSFVSIENARLNLNKEQEGRDFEKVHAEARARWNDDLSRILVEGGTEDQKTVFYTAMY
                     HLLIHPNVLQDVNGEYPAMESDKIMTASGNRYTVFSLWDTYRNVHQLLTLVYPERQIDM
                     VRTMLDMYREHGWLPKWELYGRETLTMEGDPSIPVIVDTWMKGLRDFDINLAYEAMYKS
                     ATLPGAENLMRPDNDDYMSKGYVPLREQYDNSVSHALEYYIADFALSRLAGALGKKEDA
                     KLFYNRSLGYKHYYSKEFGTLRPILPDGTFYSPFNPKEGENFEPSPGFHEGNSWNYTFY
                     VPHDVYGLARLMGGKKSFINKLQMIFDEGLYDPANEPDIAYPYLFSYFKGEEWRTQKET
                     QRLLAKYFTTQPDGIPGNDDTGTMSAWAIFNMIGFYPDCPGLPEYTLTTPVFDKVTIRL
                     DPKWYKERELVIESTRQKPDALYIHNVKIGGKKINRFRITHEELVHGGLLEFSIR"
     CDS             2935..5001
                     /locus_tag="ctg45_84"
                     /transl_table=11
                     /translation="MKKGFVSCLLFMCLGMAGCRQKDVEIRIIPQPQSVETTSGTYRLQ
                     KQATFTSNLPETEGKEFAEYVQASPLGLQLSTEESEKAAVQFVIIAPGNEHDSTESYQL
                     EITSKGIVVSAPSGAGLFYGFQTLLQLADADTDGTYTLPLVDIKDTPRFAYRGLHQDVS
                     RHFRTKEFIKKQLDAMARYKLNTLHWHLTDGAGWRLEIKRYPELTEQAAYRPYPNWKAW
                     WKGGRKYCTKDAPGADGGYYTQDDAREIVEYARQRHITVIPEIEMPGHSEEVLAVFPQL
                     SCSGKPYVNSEFCIGNEDTFTFLQNVLLEVMDIFPSEYIHVGGDEANMESWKKCPLCQK
                     RMKAEGLSDVKELQSYLIHRMEKFLNDHNRQLLGWDEILEGGLAPRATVMSWRGEEGGI
                     TAARAAHDVIMTPGEFCYLDAYQDDPTSQPEAIGGYLTLEKVYSYNPVPKVLTKQEAAY
                     IKGVQANVWAEYISTPEHMEYMIYPRLLALAEVAWTQPEQKNWEHFRQSALKEVSWLQA
                     HGYHPFDLSKEVGERPQAATRIEHLGLMKPIHYTTPYAPQYTAGGDSALVDGVRGGWTY
                     GDKRWQGFLNTDMDVTIDLEKVTEITSVAAEFMQLSGPYVWLPREVIISVSDDGKSFTE
                     VQRLSTDVPTTEDRLVFRTYQWEGKASARYVRYRALSNGIEGGWLFTDEIVIK"
     CDS             complement(5161..5493)
                     /locus_tag="ctg45_85"
                     /transl_table=11
                     /translation="VLHSKFEDLYNDAAEKVDEIAERILMLGGTPANKFSDYLKMSNIN
                     EVDRVSNGEKALENILETYSHLIGEERKLLSIASQAGDEVTVALMSDYLKEQEKMVWML
                     TAYNNK"
     CDS             5772..6698
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     56.7; E-value: 5.7e-18)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg45_86"
                     /sec_met_domain="LysR_substrate (E-value: 2.8e-45,
                     bitscore: 146.8, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 8.7e-18, bitscore: 56.7,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIQQLEYILAVDQFRHFAKAAEYCRVTQPTLSAMIQKLEDELGV
                     KLFDRAMQPVCPTRVGEKVIAQARTILAQASQVKEIISEEKRSLSGTFRLAVLPTIAPY
                     LLPRFFPQLMEKYPELDVRVTEMKTKDIRQALRDGEVDAAILASLLEDTALSEEILFYE
                     QFYGYVSRKEPLFKHDVIRTSDITGERLWLLDEGHCFRDQLVRFCQMEAVKLHQMAYHL
                     GSMETFMRMVEGGKGITFVPELAVSQLSNEQKELVRPFAIPRPTRPIVLTTNKDFIRGS
                     LLSVLKDEIRAAVPKEMLSLQAVQCLV"
     CDS             complement(7117..7272)
                     /locus_tag="ctg45_87"
                     /transl_table=11
                     /translation="MKTAKGLKVRVKTIYDNIQFIKMDFKESKSSSQIPTAQQLNISAY
                     TAKTNY"
     CDS             complement(7269..7871)
                     /locus_tag="ctg45_88"
                     /transl_table=11
                     /translation="MKKLNFIAATMILVLTPFLQSCLDDDGPSYSDLTIATLKATDADS
                     YYFGLDSGRKMYPGDDSAVRNYPIVDGKRVFVWFHQLEEQVPGYDYNIQVVQMDSILTK
                     DIIPLTKATADSIGDNKINVTYHWIAQGYLTMEFQYYGTRNPNKKHMLNLVHNEDMELV
                     DEEGYINLEFRHNAFDDNGGSLGEGIVSFNLDKVAEV"
     CDS             8090..8641
                     /locus_tag="ctg45_89"
                     /transl_table=11
                     /translation="MEEQELTELCRQGNNRARKELYEQYSGRMLGICLRYAGDRDTAQD
                     LVHDGFLKIFASFDKFTWRGEGSLRAWMERVMVNVALQYLRKNDVMNQAMALDEAPETY
                     EEPDIAAVEAIPQKVLMQFIEELPAGYRTVFNLYTFEDKSHKEIAQLLGINEKSSASQL
                     FRAKSVLARRVKEWLMVNDR"
     CDS             8638..9903
                     /locus_tag="ctg45_90"
                     /transl_table=11
                     /translation="MKDEKMKDKEMWMDKLKEKLQDYSEPMPASGWEQLEKELVPPVEK
                     RILYPYRKWVATAAAVLLVAATSLSIYFLNTPTAEEIRRTATPMLAADPDILPQTDAPD
                     VQVAKVEPARAIRPIVAQAKKIAERQGTEPSVPVEAVREIADGKEAVQQIVNEKEEIEK
                     KEPVVAKEESPVVKSHKRSGQDKLHIPVEKPESNKGRWSLGAAVGNAGGVSLTGNDLAG
                     GGIPNEQRLNLLSNAAEGEIIRIPDNQMVVFKEGVPYLKRMDEIVDIKHHQPISFGLSV
                     RKGLAKGFSVETGLTYTLLSSDVEMSGGNAMIDQKLHYIGIPVRANWNFFDKDRFTLYV
                     AAGGMIEKCVYGKLGSEKQTVKPVQLSVAGAVGAQFNATKHVGIYVEPGVAYFFDDGSN
                     VQTIRKETPCNFNIQAGIRFTY"
     CDS             complement(10001..10759)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 76.3;
                     E-value: 9.1e-24)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_91"
                     /sec_met_domain="Radical_SAM (E-value: 8.1e-29, bitscore:
                     93.7, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNFQFSTFNFQLIKVHSYESMGTFDGPGLRLVVFLQGCNFRCLYC
                     ANPDTIAVKGGTATDPEEIVRMAINQKPFFGKRGGITFSGGEPTLQAEALLPLFHRLKE
                     EGIHICLDSNGGLWNEHVEKLLKLTDLVLLDIKEFNLPHHQKLTGRSNEQTLHTAAWLE
                     EHKRPFWLRYVLVPGYSDFEEDIRAMGQQLGSYQMIQKVEILPYHTLGVHKYEAMKQEY
                     QLKGIKENTPEQIEQAANLFKKYFKTVQIN"
     CDS             complement(10762..11121)
                     /locus_tag="ctg45_92"
                     /transl_table=11
                     /translation="MPINIIGDKSYSFALRIIKAYKFLSEQKREFILSKQLLRSGTAIG
                     ALCREAEHAQSKADFLNKMNIALKEANETEYWLMLLKDSDYISIDSYDSIRNDCSELIK
                     LLASIVKSTKASLNK"
     CDS             complement(11159..13387)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_93"
                     /sec_met_domain="Gly_radical (E-value: 4.7e-46, bitscore:
                     148.4, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate1 (E-value: 0.0, bitscore:
                     1170.3, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELNKTFNDGLWSKEINVRDFVSNNITPYYGDASFLQGPTERTKA
                     VWNCCLKALEEERANNGVRSLDYQTVSTISSHKAGYIDKENELIVGLQTDELLRRAIKP
                     FGGINVVAKACHENGVEVDERVKDIFTHYRKTHNDGVFDVYTEEIRSFRSLGFLTGLPD
                     NYARGRIIGDYRRLALYGINRLIEAKLEDLKGLTGPMTEARIRLREEVAEQIKALKEMK
                     IMGEYYGLDLSRPAYNAQEAVQWVYMAYLAAVKEQDGAAMSLGNVSSFLDIYIEYDLAH
                     GNIDETFAQELIDQFVIKLRMVRHLRMQSYNDIFAGDPTWVTESIGGRFNDGRTKVTKT
                     SFRFLQTLYNLGASPEPNMTVLWNPDLPEGFKEFCAKVSIDTSSVQYENDDLMREVRQS
                     DDYGIACCVSYQEIGKQIQFFGARANLAKALLLAINGGRCENTGTVMVKDIPVLTGDVL
                     KFEEVMANYKKVLTEIARVYNDAMNIIHYMHDKYYYEKAQMALIDTNPRINLAYGVAGL
                     SIAIDSLSAIKYATVTARRNDIGLTEGFDINGEFPCFGNDNDKVDHLGVDLVYYFSEEL
                     KKLPVYKNARPTLSLLTITSNVMYGKKTGATPDGRAKGIAFAPGANPMHGRDKNGAIAS
                     LSSVAKLRYRDSQDGISNTFSIVPKSLGASAEDRIENLITMMDGYFTKGAHHLNVNVLN
                     REMLEDAMEHPEKYPQLTIRVSGYAVNFIKLSREHQLEVLSRSFHERF"
     CDS             complement(13547..13726)
                     /locus_tag="ctg45_94"
                     /transl_table=11
                     /translation="STTVFKTAAIDHSATSPKCPLLFLYQGLHYQPTKTRIKVLVVKSG
                     AKIQRDFKPPNNFI"
ORIGIN
        1 ataaagataa tccggataaa gtgctatacc gtacccgtga ttatctgctt gcacctgctg
       61 caccttatga gctacaggga gatgtaccta atgttgtatt cccttgtgca gcattgcagg
      121 atggcgagag agttgccgta tactacggag cagccgatac tgtaacggga cttgcttttg
      181 gctatatttc cgaaatcatt gaatttataa aaagaacaaa cattggatga tttacgattt
      241 tacgattgat gttagagtag aagttagagt tagagagaat ataatagaga gagttccttc
      301 aatcgtaaat cgtaaattgt ctaatcgtca atctttcttg atcctttcaa ctttcaatta
      361 aataaatgaa acgactttta ttgacttaca cattggctgt ctttctgctt ccggcttttg
      421 ccggaggtgg agagaagctt tcccctgttg attatgtgaa tccttttatt ggtaccacca
      481 actttggtac aacaaatccc ggagcggttt gtccgaatgg gatgatgtct gttgtacctt
      541 tcaatgtgat gggttccgcc gataacaagt atgataaaga cgcccgttgg tggtctactc
      601 cttatgagta tcataactgt ttttttaccg gatactccca tgtaaatttg agtggagtgg
      661 gttgtccgga gttgggctct cttttgttaa tgcctaccac aggagagttg aatgtggatt
      721 acaaggaata tggaagccgt tataaagacg agcaggcttc gccgggttac tacacaaatt
      781 atctgactaa atacaatgtg aagactgaag taactgccac cccccgtacg ggcgttaccc
      841 gttttacatt tccggaagga aagagtcata tattactcaa tttgggtgaa gggcttacca
      901 acgaatcggg tgccatgctt cgccgggtga acgcccagga gatagaagga gttaaactct
      961 taggcacttt ctgttataat cctcaggcgg tatttcctat ctattttgtg atgcgtgtca
     1021 acaaactccc ttcgcaaaca gggtattgga agaaacagcg tccgatgacc ggcgttgaag
     1081 ccgagtggga tccggataat ggtaaatata aactttatac caaatatgga aaagagatcg
     1141 ccggagatga tatcggtgcc tttttttcat tcgacaccga agacggtgaa caggtagaag
     1201 tagaaatggg tgtttccttt gtaagtatag aaaacgcccg tctcaatctg aacaaggagc
     1261 aggaaggccg ggattttgag aaagtacatg cagaagcccg tgctcgctgg aatgatgatt
     1321 tatcccgtat tcttgtagag ggagggacag aagatcagaa aaccgttttc tatacagcca
     1381 tgtatcattt gctgattcat cccaatgttt tgcaggatgt caacggagaa tatccggcta
     1441 tggaaagcga taaaataatg actgccagtg gcaatcgtta cacggtattc tctttgtggg
     1501 atacgtatcg gaatgtgcat cagttgctta cgctggttta tccggagcgg cagatagaca
     1561 tggtacgtac catgcttgat atgtatcgtg aacacggctg gcttccgaaa tgggagttgt
     1621 atggtcgtga gacgctgaca atggagggag atcccagtat tcctgtgatt gtagatacct
     1681 ggatgaaagg tttacgcgat tttgacatta atctggctta tgaagccatg tacaaatcgg
     1741 ccactctgcc cggtgctgag aatctgatgc gcccggacaa tgacgattat atgtctaaag
     1801 gttatgtgcc tctgcgcgaa cagtatgata attcggtttc tcatgcattg gagtattaca
     1861 tagcagactt cgctctttcc cggcttgccg gtgctttggg aaagaaagag gatgccaaac
     1921 tgttctacaa tcgctcatta ggatataaac attattacag taaagagttt ggtacgcttc
     1981 gtcccatact tcctgacgga actttttatt ctcccttcaa tccgaaagaa ggtgaaaact
     2041 ttgaacccag tcccggattt catgaaggta attcgtggaa ttatacattc tatgtgcccc
     2101 atgatgtata tggactggcg cggttgatgg gagggaagaa gtctttcatc aacaaactgc
     2161 agatgatatt tgatgaaggt ctttatgatc ctgccaatga acccgatatt gcctatcctt
     2221 atttattctc ttattttaaa ggagaagaat ggcgcacgca gaaggagaca caacgtttat
     2281 tggctaagta ttttactact cagccggacg gtattcccgg gaatgatgat acgggaacga
     2341 tgtctgcctg ggccatcttt aatatgatag gtttctaccc ggattgcccg ggattgccgg
     2401 aatatactct taccactcct gtttttgata aagtgaccat ccggcttgat ccgaaatggt
     2461 acaaagaacg tgagcttgtg atagagtcta cccgtcagaa acccgatgct ttgtatattc
     2521 ataatgtaaa aataggtggt aaaaagataa accgcttccg tatcactcat gaggagttgg
     2581 tacacggcgg gttgttagag ttttctatca ggtaaatgtt tttccccaat tagtttagta
     2641 atgaaggtaa aaaggagaga ctgtccagac attgtttgtt aggacagtct tgtttttatt
     2701 agcacttttg ttttctcaat tgtattatta gtacgaaccg ggggcaccac cacagaggac
     2761 acagagaaca ctgagtttta aatttctgat gaaacgcgga tgatcgcaga ttaaaagctg
     2821 tagttcttta ttttagatta atttttcttt gagaagctct gtatccactg tgtactttgt
     2881 ggtgaaatac attcacatta ttagtacgag tatttattta ttatatttga tagtatgaaa
     2941 aaaggatttg tttcatgttt attgtttatg tgtcttggga tggcaggatg tcggcagaag
     3001 gatgttgaga tacggatcat tccgcaacca caatcggttg aaactacttc cggaacttac
     3061 cggttacaaa aacaagctac gtttacttct aatctgccgg agacagaggg aaaagagttt
     3121 gcagaatatg tgcaggcttc tcctttgggt ttacaattga gtacagaaga gtccgaaaaa
     3181 gcggctgttc agtttgtgat aattgctccc ggcaacgaac atgattcgac agagagctac
     3241 cagttagaaa taacttcaaa aggtattgtt gtgtctgctc cttccggtgc cgggctgttt
     3301 tatggctttc aaacattgtt gcaattggca gatgccgata cagacggtac ctataccttg
     3361 ccattggttg atatcaaaga tactcctcgt tttgcttaca gaggtttgca ccaggacgta
     3421 tcccgtcatt tccgaaccaa agaatttata aagaaacagt tggatgccat ggcacgctat
     3481 aagctgaaca cccttcattg gcatctgaca gatggtgctg gctggcgtct ggaaattaaa
     3541 cgctatccgg aactgacgga gcaggcagct tatcgtcctt atcctaactg gaaagcatgg
     3601 tggaaggggg gccgtaagta ctgtacaaaa gacgctccgg gcgcagacgg aggatattat
     3661 acgcaagatg atgcacggga gattgtggaa tatgctcggc aacgtcatat caccgttatt
     3721 cccgagatag aaatgccggg acactcggaa gaagtgttag ctgtttttcc tcagttgtct
     3781 tgttccggca aaccctatgt aaattcggaa ttctgtatcg gcaatgagga cacctttact
     3841 tttctgcaaa atgtattgtt ggaggtgatg gatatctttc cttctgaata tattcatgtg
     3901 ggcggtgatg aggcgaatat ggaaagctgg aaaaagtgtc ctttgtgcca gaagagaatg
     3961 aaggcggagg gattgtctga tgtgaaagaa ctgcaaagct atctcattca tcgaatggag
     4021 aaattcctca atgaccacaa ccgtcagtta ttgggatggg atgaaatctt ggaaggtgga
     4081 ctggctcccc gtgccactgt gatgtcatgg cgtggagaag agggaggaat tactgctgcc
     4141 cgtgcagcgc acgatgtgat aatgactccg ggagagtttt gttatctgga cgcttatcag
     4201 gatgacccga ccagtcagcc cgaagctatc ggaggctatc tgactttgga gaaggtatac
     4261 tcttacaatc ctgtacctaa agtactgaca aagcaggagg ccgcttatat aaagggggta
     4321 caggcaaacg tatgggcgga atatatatct actcccgaac atatggaata catgatttat
     4381 ccccgcttgc tggcattggc agaagtagca tggacacagc cggaacagaa aaattgggaa
     4441 cacttccggc agtctgccct gaaagaagtt agctggttgc aggctcacgg atatcatcct
     4501 ttcgatctga gtaaagaagt aggagagcgt ccgcaggcgg ccacacgcat tgaacactta
     4561 gggctgatga aaccgattca ttacacaact ccgtatgcac ctcaatatac agccggaggt
     4621 gattcggcac tggtagacgg ggttcgcggc ggatggacgt atggagataa gcgctggcag
     4681 ggtttcctga atacggatat ggatgttacg attgatctgg agaaggtgac ggaaattact
     4741 tcggtagctg ccgagtttat gcaactgtcc ggcccttatg tatggttacc gcgtgaggtg
     4801 attatttctg tttctgatga cggaaagtca tttacggaag tgcaacgtct atctaccgat
     4861 gttcctacta cggaagaccg gttggttttc cggacatatc aatgggaagg aaaggcgtca
     4921 gcccgttacg ttcgttaccg ggctttatcc aatgggatag aggggggatg gcttttcacg
     4981 gatgaaattg tgattaaata gagatgactg aatgtatata cttgacaaac aataggataa
     5041 tttgatttgt tactttgttg tcatacaata aaaagagcca caataaccgt aaattgtggc
     5101 tctctcgatt tagaaacagt tttgttttaa aaaggaaatc aaaacttgct gtggggggac
     5161 ttatttgttg ttataagctg tcagcatcca aaccattttt tcttgttctt tcagataatc
     5221 gctcatcaaa gctactgtaa cttcgtcacc ggcttgtgaa gcgatggaca acagtttgcg
     5281 ttcttcgccg atcagatggc tgtaagtttc cagaatattc tctaaagctt tctcgccatt
     5341 gctcacccgg tctacttcgt tgatgttgga catcttgagg taatcactga acttattggc
     5401 aggagttccg cccagcatca ggatacgttc ggctatttcg tcaactttct cggctgcatc
     5461 attatagaga tcttcgaact tgctgtggag cacaaagaaa tcatgccctt taatattcca
     5521 gtggaaaccg cgaaggttgg tgtaatatat ctggaaatct gctaataatt gttacaaaga
     5581 tgctactacg ttgttcactc ccgattcgtt caacttgatg taatctaatg ttttcataac
     5641 ttgttttatt taatttgttt atactatttt tctttttcgt attgcaaaga taaggcgaaa
     5701 atgcatgcgt gtcaaactga taatttctat ctttgcatag acagaatcta taacctataa
     5761 aactttgata gatgacaata caacagttgg aatatatact tgccgtagac cagttcaggc
     5821 attttgccaa ggctgcggaa tactgccggg tgacgcaacc tactttgagc gctatgattc
     5881 agaaactcga agatgagctg ggagttaaac tcttcgaccg tgcaatgcag ccggtatgcc
     5941 ccacacgggt gggagaaaaa gtgattgctc aggcccgtac catacttgcc caggcttcac
     6001 aggtgaaaga gattatcagt gaagagaaac gttcgctgtc cggtactttc cgtttggcgg
     6061 tattacctac tatcgctcct tatctgttgc cacgtttttt tccgcaactg atggaaaagt
     6121 atccggagct ggatgtacgg gtgacggaga tgaaaacgaa agatatccgc caggcattac
     6181 gcgacggaga agttgatgct gctattttag caagtctgct cgaagatact gcgttgtcag
     6241 aagagattct tttctatgaa cagttttatg gatatgtatc ccgcaaggag ccgttgttca
     6301 agcatgacgt gatccgtacg tccgatatta cgggagaacg gttatggttg ctcgatgaag
     6361 ggcattgctt ccgcgatcag ctggtgcgtt tctgccagat ggaagctgtg aaactgcatc
     6421 agatggcata tcacctggga agtatggaga catttatgcg tatggtagag ggcgggaaag
     6481 gaattacatt cgttccggaa ctggcagtgt ctcaactctc caatgaacaa aaagagttgg
     6541 tgcgtccgtt tgccattccc cgtcctacaa ggcccattgt gctgaccacc aataaagact
     6601 ttatccgtgg tagcttgctt tctgtactga aagatgagat acgtgcagct gtgcctaagg
     6661 agatgcttag tttgcaggct gtacagtgct tggtttaatg tacagtggac aattgaccgt
     6721 gggcggtgta actaaacgga agtacctata taaacggcat cattaccctt atccggtgtt
     6781 gtattttgtc cttctcagaa aggaacgctc ttttccccgg tgcacagtct tgttttacat
     6841 gtacatgtaa agctgcataa gatgtacatg tcgtactgtc ccacatgcac atgtcgtact
     6901 gctttacatg tacatctaaa acagcgttac acaccgaggc ttcatacgtt actctacgag
     6961 atagagcttt atcgataccg gagaaagaga tagatggtaa tggcagacag gacttagcac
     7021 aaaactgaat aactttagtc caaatgataa gataaaaaaa gaacgatgac aatcatggga
     7081 agttgtcatc gttcgtcaca ttttattata tcagaattag tagttcgttt tagccgtgta
     7141 tgcagaaata tttagttgtt gtgcagtagg tatttgactg ctgcttttgg attctttgaa
     7201 atccatcttt ataaactgta tattgtcgta tatcgtcttt acacgaactt tcagtccttt
     7261 ggctgttttc atacttcggc tactttatcg agattgaagg agacgatgcc ttcacccaag
     7321 ctaccgccgt tatcatcaaa tgcattgtgg cggaattcta aattgatgta accctcttcg
     7381 tccacaagtt ccatgtcttc gttgtgaacc agattgagca tgtgtttctt gttggggttc
     7441 cgtgtaccgt aatactggaa ttccattgta agatatccct gtgcaatcca atggtaagtg
     7501 acgtttatct tattatcacc gatgctatct gctgtagctt tcgtaagcgg gatgatatct
     7561 ttggtcagga tagagtccat ttgtactact tgaatgttat aatcatatcc cggaacttgc
     7621 tcttcgagct ggtgaaacca tacaaataca cgctttccat ctacaatcgg atagttgcga
     7681 actgcagagt catcacccgg atacatcttt ctgccactat ccagaccaaa ataataactg
     7741 tcggcatcag tggctttgag ggtggcaatg gtcaaatcag aatagcttgg tccgtcatcg
     7801 tccagacatg actggaggaa aggagtaagg accagaatca ttgttgctgc aataaaattt
     7861 aatttcttca taagtttgtt tggttttctt tttacagtta cacttaatta atggctatca
     7921 tcgcccggcg tacctccccg tgtggggggc acactgtatg aaaaatacag gatataaaag
     7981 aatattgcac gacagactgt taaagaaata aaagcaataa aagacttgct ctctctatgc
     8041 agtatttcta tctttgctgc atttataaga taaacacgtg ttaaagagaa tggaagaaca
     8101 ggagctgaca gagctatgca ggcagggaaa caaccgtgcc cgcaaagaac tttatgagca
     8161 gtattctggg aggatgcttg gcatctgtct ccggtatgcc ggagataggg acacagcaca
     8221 agacctggta catgacggtt tcctgaaaat ctttgcttct tttgataagt tcacctggcg
     8281 aggcgaaggt tctctcagag catggatgga gcgtgtaatg gtaaatgtgg cattacagta
     8341 tttgcgtaaa aatgatgtga tgaatcaggc aatggcgctt gatgaagccc ccgaaactta
     8401 tgaagagccg gatattgcgg cagtggaggc tataccgcaa aaagtactga tgcagtttat
     8461 tgaagagtta cccgcaggct atcgtaccgt gttcaactta tacacgtttg aagataagtc
     8521 gcataaagag attgctcagt tactgggtat aaatgaaaag tcctcggctt cgcagttgtt
     8581 tcgtgcaaag agtgtattgg ccaggagagt gaaagaatgg ttaatggtga atgacagatg
     8641 aaagatgaga agatgaaaga taaagaaatg tggatggaca agctgaagga gaagttgcag
     8701 gactactccg agcctatgcc cgcttccggt tgggaacaac tggagaagga attggtgccg
     8761 cctgttgaaa agcggatact gtatccttat cgcaaatggg tagcaacagc agcggcggta
     8821 ttgctggtgg ctgctacatc cttgagcatc tacttcctga atactcctac tgctgaagag
     8881 attcgtcgta cagctacccc gatgttggct gctgatccgg atatattgcc tcaaacagat
     8941 gcgcccgatg tacaggtggc gaaagtagag ccggcacgtg ctatccgtcc gatagttgca
     9001 caagcgaaga aaatagcgga gagacaggga accgaaccct cggtacctgt tgaggctgtt
     9061 cgtgaaatag ccgatggaaa ggaggctgtg cagcagatag tcaacgagaa agaggaaatt
     9121 gaaaaaaaag aaccggtagt agcgaaagaa gaatcacctg tggtgaaatc acataaaaga
     9181 tccggacagg ataaactgca tatcccggta gaaaagccgg aatctaataa aggacgttgg
     9241 tcacttggtg cagcggtagg caacgcagga ggagtctctc ttacaggcaa tgacctggcg
     9301 ggtggtggta tacctaatga acaacggctc aacctgctat ccaatgccgc tgagggagag
     9361 attattcgca tccccgacaa tcaaatggtg gtatttaaag aaggggtacc ttacctgaaa
     9421 cgtatggatg aaattgtgga catcaaacat catcagccta tctcttttgg cttgtcggta
     9481 cgtaaagggt tggcaaaagg gttttcggtg gaaaccgggt tgacgtatac attactttct
     9541 tcggatgtcg agatgagtgg cggtaatgcc atgatcgatc agaaattgca ttatataggt
     9601 attcctgtcc gggctaactg gaactttttc gataaggacc gtttcacatt gtatgtggct
     9661 gccggtggaa tgatagagaa gtgcgtatat ggaaaattag ggagtgaaaa gcaaacagtg
     9721 aagccggtgc agctttcagt agccggtgca gtgggcgcac aattcaatgc gacaaagcat
     9781 gtgggtattt acgtggaacc cggagtggca tatttcttcg atgatggttc caatgtgcaa
     9841 accattcgta aggaaacgcc gtgtaacttc aatatacagg caggtattcg cttcacctat
     9901 taaaaatagc attaaatata aaatgaaacg gaggcttttt taagtctccg ttttttttgt
     9961 gaattacacc gcttggcgta cttccccgtg cgggaagcac ctaatttatt tgtactgttt
    10021 tgaagtattt tttgaacagg ttggcagcct gttcgatttg ttccggtgta ttttctttta
    10081 ttccttttag ctgatactct tgtttcattg cctcatattt gtgtacacct aatgtgtgat
    10141 aggggagtat ttctactttt tggatcatct ggtaactacc cagttgttgt cccattgcac
    10201 ggatatcttc ttcaaaatca ctgtatcccg gcaccaacac atagcgtaac caaaagggac
    10261 gtttatgctc ttccagccag gcagctgtat gtagcgtttg ttcattactt cgtccggtaa
    10321 gcttttggtg atgtggaaga ttgaattctt taatatccag caaaacgagg tctgtcagtt
    10381 tcaaaagttt ctctacatgt tcgttccata atccgccgtt gctgtcgaga cagatatgga
    10441 taccctcttc tttcaatcgg tgaaacaggg gtaacagcgc ttctgcttgt agcgttggtt
    10501 cacctccgga gaaagtaatc cctccacgct ttccgaaaaa aggtttctga ttgatagcca
    10561 tgcggacaat ttcttccggg tcagtggctg ttccgccttt tacagcaatt gtatccggat
    10621 tggcacaata aagacaacgg aaattacagc cttgaagaaa aacaacgagc cgtagtcccg
    10681 gcccgtcgaa tgttcccata ctttcataag aatgaacttt gattaattga aaattgaaag
    10741 ttgaaaattg aaaattcata gttatttatt gagtgatgct ttggttgact tgacaatgct
    10801 ggctaatagc tttattaatt cgctacaatc gtttcttata gagtcgtaag agtctattga
    10861 aatataatcg ctgtctttga gcaacataag ccaatattcg gtctcgtttg cttcttttaa
    10921 agcaatattc attttattga ggaaatctgc tttactttgg gcatgttcag cctcccggca
    10981 taaagctcct attgcagtgc cacttcttaa taattgtttg gataaaataa attccctttt
    11041 ttgctcagac aaaaacttat aagcttttat gatcctaagt gcaaatgagt acgatttatc
    11101 tcctataata tttattggca taactattca ttttcaattt tcaactttca attttcaatt
    11161 aaaaacgttc atggaacgaa cggctcaaaa cctccagttg atgttcgcgg ctcagcttga
    11221 tgaagttcac tgcataacct gatacacgaa tagtcagttg cggatatttc tccggatgct
    11281 ccatggcatc ttcaagcatt tcgcggttca atacattgac attcaggtgg tgtgcacctt
    11341 tggtgaagta gccatccatc attgttatca ggttctctat acgatcttcg gcagaagctc
    11401 cgagtgattt cggtacgatg gagaatgtat tactgatacc atcctgcgag tcacgatagc
    11461 gtaactttgc aacagaactg agggaggcga tagcaccatt cttgtcgcgt ccgtgcatcg
    11521 ggttggctcc cggagcaaag gcaatacctt tggcacgtcc gtccggagtg gcacctgtct
    11581 ttttaccgta catcacattg gaagtgattg tcagcaatga aagggtagga cgggcattct
    11641 tgtaaaccgg cagctttttc agctcttcgc taaagtagta aacgaggtct acacctaagt
    11701 gatctacttt atcgttgtca ttaccgaagc aagggaattc gccgttgata tcaaaacctt
    11761 ctgtcaggcc gatgtcattt cggcgggctg ttaccgttgc atatttaatg gcagacagag
    11821 agtcgatagc aatagaaagt ccggctacgc catatgccag gttgatgcgg ggattggtat
    11881 cgataagtgc catctgtgcc ttctcgtagt aatacttatc gtgcatgtag tggatgatat
    11941 tcattgcatc attatacacg cgggcaattt cagtcaacac cttcttatag ttggccatta
    12001 cctcttcgaa cttcagtaca tcacctgtca gcacaggaat atctttcacc ataacagtac
    12061 ccgtgttttc gcaacgtccg ccattaatag caagtaacag agcctttgcc aggttggcgc
    12121 gtgcaccaaa gaactgtatc tgttttccta tttcctgata agatacgcag caggcaatac
    12181 catagtcgtc cgattggcgt acttcacgca tcagatcatc attttcgtat tgtacagaag
    12241 aggtgtcgat agaaactttt gcacagaatt ccttgaaacc ttctggtaga tcgggattcc
    12301 acaatacagt catattaggt tccggagatg ctcccaggtt gtatagtgtt tgtaagaaac
    12361 ggaaagaagt cttagtcacc tttgtacgtc cgtcgttgaa acgtccgcct atggattcgg
    12421 ttacccaggt ggggtctccg gcaaaaatat cgttataaga ttgcatgcgt aagtgacgta
    12481 ccatacgcaa cttgataaca aactggtcaa ttagttcctg tgcaaatgtc tcgtcgatat
    12541 taccatgagc taaatcgtat tcaatataaa tatcaaggaa agacgatacg ttacccaatg
    12601 acatagcagc tccgtcctgt tcttttacag ctgctaaata agccatatat acccactgaa
    12661 ctgcttcctg tgcgttgtat gccgggcggc tgaggtcgag tccgtagtat tcacccatta
    12721 ttttcatttc cttcagtgcc ttgatctgtt cggccacttc ttcgcgaagc cggatacgtg
    12781 cttcggtcat gggaccggtt aatcctttca ggtcttcaag tttggcttca atcagacgat
    12841 tgataccata aagggccaga cgacgatagt caccaatgat acgtccgcgg gcataattat
    12901 cgggaagtcc ggtaaggaat cccaatgaac ggaatgaacg gatctcttcg gtatatacat
    12961 caaatactcc gtcgttgtga gttttgcgat aatgagtaaa tatatctttt acgcgttcgt
    13021 ctacctctac accattttca tggcaggctt ttgctactac attgatacca ccgaacggct
    13081 tgatggcgcg tcttaacagt tcatctgtct gtaatccgac gataagctcg ttttctttat
    13141 caatgtatcc ggctttatga gaggagatgg ttgaaacggt ctggtagtca agagagcgca
    13201 caccattgtt ggctctttct tcttcaagtg ctttgaggca acagttccac actgcctttg
    13261 tacgttctgt aggtccttgc aggaaggatg catctccata ataaggagta atgttattac
    13321 tgacgaaatc tcttacgttg atttctttgc tccaaagtcc gtcattaaag gttttattca
    13381 attccatact taaatattag ttagtggttg ggttatccat tcttctttag agcacgcaaa
    13441 gttacaagca ttttttcata ttataggtat aaatatcctc tattttgtgt ttaatagcat
    13501 aaaataccta taaataagga gagaaaatta aagacttatt ctttttttat ataaaattgt
    13561 ttggaggttt aaaatctctt tgtatctttg caccgctttt aacaacaagc acctttatac
    13621 gagtcttggt gggctgataa tgtaagccct gatagaggaa taaaagagga cattttggag
    13681 aggtggcaga gtggtcgatt gcggcggtct tgaaaaccgt tgtact
//
