LOCUS       c00228_gnlPro..        14907 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GDBMDPLJ_228.
ACCESSION   c00228_gnlPro..
VERSION     c00228_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 18:21:43
            Original ID  :: gnl|Prokka|GDBMDPLJ_228
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14907
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14907
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[861:4907]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      862..4907
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..14907
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14907
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(94..825)
                     /locus_tag="ctg228_1"
                     /transl_table=11
                     /translation="MEKNKVGEFHFVTESYLMDFRGRITIPMIGTYLLHAASCHAADRG
                     FGYNDMTERHTAWVLSRLAIEMTSYPAMSESVTLYTWVDEVGKLFTSRCFELVNGEGKT
                     FGFARSIWAAIDMETRRPTLLDVEGLSAYITDRPCPIEKPGKIAPVENNTSGEPYRVKY
                     SDLDVNGHLNSIKYMEHLLDLFDISLFREKEISRFEIAYQSEGKYGMELTLHNQEVSLD
                     KYNMAICNDGKAISRAAVTWI"
     CDS             complement(862..1416)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg228_2"
                     /sec_met_domain="ALS_ss_C (E-value: 2.1e-18, bitscore:
                     56.7, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKQLYTVIIFSENTVGLLNQITVIFTRRQLNIETLSVSPSAIK
                     GIHKFTITTFADEDTIDKVVKQIDKRVDILKAYYNTDEDLVYQEIALYKLSTELFIKMG
                     TVEDLIRKYNARILEMNEDCVVLEKSGHYDETQALFKELSETIGVLQFIRSGRVAITKS
                     KVERLSDMLSAMEKKLQEKHV"
     CDS             complement(1429..3129)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg228_3"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.2e-50, bitscore:
                     161.7, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKQKITGSEALLKALIAEGVDTIFGYPGGQAIPIYDSLYDYRDQ
                     LKHILVRHEQGATHAAQGYARVSGKVGVTVVTSGPGATNTITGIADALMDSTPMVVIAG
                     QVPSPLLGTDAFQEVDVIGITQPITKWAYQIRRPEEIAWAVSRAFYIASTGRPGPVVLD
                     LAKDAQVGLVDYEYQKVDYVRSYQPEPDIREERIEAAASLINNAKKPFCLVGQGVILGG
                     AEEELKEFLLKNDIPAGSTVLGLSALPSDFPLNKGMLGMHGNVGPNRKTNECDVLIAIG
                     MRFDDRVTGDLKTYAKQAKIIHLDIDNSEIGKNVPVDVKVLGNAKHTIPMITALLEERK
                     RPEWNAEFEPDEKEEYNKVIEKELYPTEGQLKMGEVVRKVSEATDNDAILVTDVGQNQM
                     MGVRYFKYKQTRSVVTSGGLGTMGFGLPAAIGAKLGAPDRTVCFFTGDGGIQMTIQELG
                     TIMQENLNVKIIVLNNYFLGMVRQWQELFFNERYSNTIMKNPDFVAIAKAFGIASRAVD
                     KREDLDEAIAEMLNHDGAYMLVANVETCGMVYPMVPAGGSVTNMILGDK"
     CDS             complement(3156..4907)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg228_4"
                     /sec_met_domain="ILVD_EDD (E-value: 7.8e-218, bitscore:
                     714.4, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEEQFGKPIIAIVNSFTQFVPGHVHLHEIGQQVKAEIEKLGCFA
                     AEFNTIAIDDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHKADAMVCISNCDKITPGML
                     MASMRLNIPTIFVSGGPMEAGNLDGRALDLIDAMIEAADDSISDEQVEKVERSACPTCG
                     CCSGMFTANSMNCLNEAIGLALPGNGTVVATHANRTRLFKKAAKMIVDNAFKYYRDGDD
                     SVLPRSIATRQAFLNAMSLDIAMGGSTNTVLHLLAVAHEAEVDFTMKDIDMLSRKTPVI
                     CKVAPSCSYHVEDVNRAGGIIGIMNELVKARLVDGSVKRADGLTLNEAIDQYCITSVNV
                     TEEAINIYKSAPAHRFNLVLGSQESYYKELDTDRATGCIRDVEHAYVKDGGLAVLYGNI
                     AQDGCVVKTAGVDESIFRFAGPAKVFDSQDAACEGILKDKVVSGDVVVITYEGPKGGPG
                     MQEMLYPTSYIKSKHLGKECALITDGRFSGGTSGLSIGHISPEAAAGGAIGLVKDGDII
                     EINIPERTIHVKVTDEELAKRREAEEARGTKAFTPPFRQRTVSKALKAYAKMVASADKG
                     GVRIVED"
     CDS             complement(5362..6012)
                     /locus_tag="ctg228_5"
                     /transl_table=11
                     /translation="LGKYGIRLILYYHVGHGDKEWWDKQHYTRDNAGDLFTNVEKIVGE
                     ISQRYGNRLAGLWMDDGIGYYPNGASFEKIAEAAKSGNKELAICFNSWILPKLTDFQDY
                     YAGELGLSLASAGVNDPSLPLDGDGLFHGGPQDGLQATFSGTLEPGDWTHIYKDSIIGD
                     PVLSIDELTQVVKESNKRKNLPMINVRIYQDGTISPKSYALLKELNNRISKGE"
     CDS             complement(5988..6821)
                     /locus_tag="ctg228_6"
                     /transl_table=11
                     /translation="MKKQYIYFLSLFVMCLAACSNPVDPPALNLDSANINRLIPFRGEL
                     NNGVKQFYPEEPYKAFWAENWKSPEQSISWKVNTDGEDYMAEMIVSVNRMGDGEETELV
                     LSNGTDSVICRINTTGWQRCRFPRPLHFNKGTSVLSLKIGKPGKQDDFNVYLYSLEVTR
                     PETYERLRAEATSLRSNTSWMADLPYGFFFHWNSKSMPQSGEPLAYEDAVNNFDVDRFA
                     RTVYECGGKLIFFTTSWAEYYFPAPIQAIDSILPGRTTKRDLVXXXXRWVNTAFV"
     CDS             complement(6894..8006)
                     /locus_tag="ctg228_7"
                     /transl_table=11
                     /translation="MILESIEDKDFTAETKNRIIGEAKCLRAWSYFTLVQFFGDVPLRD
                     KVVTSDADVAIDRTPQADIYQFIFDDILDAEQKLPEEAQDMGRVNKWVVKAIMARIYLT
                     SAGFPMNQKENYAKAKEKALEVINSGQYSLMPTFDKVFKTERYTAETIWAQLFSAPDSY
                     SGMHNESSPIGSQTALYLPTDAFIASFDKGDMRKEWGIKPEYVNAKGNKVIARTYYNKY
                     INEEYLEQELPASNTNILTWQTQLIRLAEMYLIAAEAENEINGPAGAYQYINAIRKRAR
                     VDQNDPTNVPDLSGLSQDQFREAVLLERQHELYEEGFAWYDLKRTQTFDKVQKARGSRL
                     NVPIGAYNNTWLIPDTEILNNNIPQNPDYR"
     CDS             complement(8342..11533)
                     /locus_tag="ctg228_8"
                     /transl_table=11
                     /translation="VRLTGSNVTLKTAFKQIEQQTKLFVDYNTQEVNDSRVLTKLPKNS
                     NVKEVMEQLLEGSGCSITFSNGHIIINKQARTVSSTKNISGVVKDETGEPVIGANVVVK
                     GTTNGTVTDMNGRYSLEVPEGGVLQISYIGYNTQEVKVGSGDVVNVSLREDSEALDEVV
                     VIGYGTVKKSDLTGAVGSVQMKDVSQVGITSADRALQGQIAGVQVNARTGQPGESMMIR
                     VRGSNSLAGGNEPLYVIDGMPVEKMNSDINPEDILSMEVLKDASSTAIYGSRGANGVVM
                     ITTKRGRTGDTVLEYNGYVGVSSLRKKLDLLGKDDYIAMVNEVSQNDGNGIAITPEQAA
                     MLPNNDWQDLAYQTALTHSHQVSVSGGTDKTKLYSSLNYMNQEGIIKGSDYNRFALRIN
                     GDQKLARNLSLNASIAYSYGTQNTANSNADGWGAIAYTAMVMAPIQEIRDADGKYTNFS
                     GTPWGGTNPVGMAELYKNKTVNSRLLANMSLIYEIIDGLTFRVNAGAEVNAGSSDRYIP
                     IGLSAGGKLDGDASKSKSNYYTIINENILTYDKRFNKNHALNLMGGVTFQTYQYNDLGG
                     SGTGFLRDVYETNNLGVASTPGTPSSGYSDYRMASFLGRANYNLMERYLLTVTARYDGS
                     SKFSKNHKFAFFPSAALAWRLSEENFMQDIDWLSNLKLRASIGQTGNQSISPYQTFARL
                     GTSGPIFGDGKDIGFGLSSMANDDLKWETTTQTDIGVDFGFFSNRLNIGFDYYWKQTRD
                     LLYNATLPPSSGYSSMLRNLGRIDNKGFEISINTINMKGKVNWTTNLNITSNRSIVKDL
                     GSDVYGNKIQRIDAPIGGGNWFPLFVGKAPFQLYGYEIEGIYQTDEEARLNGEATKKAG
                     DYRYKDTDGKAGITTGDKTIIANTQPKFTFGLTNIINWNNFELSFLLIGSVGGDIVNEF
                     NKSITNIGGTWNIRKDVWENHWTPENPNAKYARASVATKDYLAFGDPSSVWVENGSYLR
                     FKDIKLAYTLPSQWFAGSRKPNISVYLSGQNLITITSYSHYDPEASWTSSAVNGWDRGV
                     YPSAKSFTLGLQVKF"
     CDS             complement(11878..12447)
                     /locus_tag="ctg228_9"
                     /transl_table=11
                     /translation="MAQVFVPYGESEQVVLPDGSKVWVDAGTLLVYPKDFTDTDTRTVY
                     LTGQASFSVRKNPEQPFVVKTTYLDVQALGTVFTVEAYPGDSCSMATLEEGSVLVSVRN
                     EDIQPTVLKPDQQLVYSHSEHTVMVHSIDASLYNMERNGYLIFENTSFSRLMASLERKF
                     NVTIHYNSQKFAGEYYNVKFSPDEKL"
     CDS             12454..12825
                     /locus_tag="ctg228_10"
                     /transl_table=11
                     /translation="MTDRFKTVGCPIGRSGSHHHQDNNGRIFQPLAIEWHRTFTNGEHG
                     KMPLQSLPITMGRIRHLRLRFLPQILQHFFLLRFCIVRLQPTPKQDTSISGKVLSEVEL
                     HELFYLVVLFHKISVFIWM"
     CDS             complement(12996..13553)
                     /locus_tag="ctg228_11"
                     /transl_table=11
                     /translation="MELPEEQHILREIARGNIKAFEQLFFDYQPRLVYFLVGLTHDKEI
                     SRDISQDLFLSIWKDREKLKDVRSFSSYLFQMARFTVYDYFDRLAVSEKYTNEFLLEAS
                     ISQSEEEAMFARELQNLINRTVEQMSPQRKLIYKMSREQGLSNDEIATRLGISKRTVEN
                     HLTAALSILRKVLYLFLFTSLG"
     CDS             complement(14005..14391)
                     /locus_tag="ctg228_12"
                     /transl_table=11
                     /translation="MFGADVPADIKSAGKIIQCNRTDAGHEDTFEHSFKFLENLAIEPA
                     GMCESMVNVITLLIEYYIGEVIIFVDNKIEMRPGFGCMKIQIVQFADKIGQCFHFIGKP
                     RIIIRLVRHAEHIHHHTAIPVKVL"
ORIGIN
        1 cttcgcgggt tactacgttt tcgtcaacgc cgccaaaatt cattactgcc attttctttt
       61 tactattaaa atgtatataa aataatttgt ttttcagatc caggtaacgg cagcgcggct
      121 gatggctttg ccgtcgttac agattgccat attatattta tcgagggata cttcctggtt
      181 atggagagtc agctccatcc catactttcc ttcggactga taagctattt cgaaacggct
      241 tatctctttt tctcggaaca ggctgatatc gaacaagtcg agcaggtgtt ccatgtattt
      301 gatactgttc aggtggccgt ttacgtccag gtcactgtac ttcacacggt aaggttcgcc
      361 ggaagtgttg ttttccaccg gagcaatttt acccggtttt tcaatcggac agggacggtc
      421 ggtgatataa gcactcaggc cctccacatc gagcaaggtc gggcggcggg tttccatatc
      481 gatagccgcc cagatagagc gggcaaagcc aaaggtcttg ccttcgccgt tcaccagttc
      541 aaagcaacgg ctggtaaaca acttaccgac ctcatccacc caggtatata aagttacaga
      601 ttcagacata gcaggataag aagtcatctc gatagccaga cgggaaagaa cccaggcggt
      661 atgcctttcg gtcatatcgt tatatccgaa tccacggtcg gcggcatggc aagaagcagc
      721 atgcaacaaa taagttccga tcatagggat tgtaatacgt ccccggaagt ccatcagata
      781 agactctgtt acgaaatgaa attctcctac tttgttcttc tccataattt actttattta
      841 caaaatgttt ccttattatt ctcagacatg tttttcctgc aacttctttt ccattgcaga
      901 taacatgtcg ctcagacgtt ctaccttact cttcgttata gcaacgcgtc cggaacggat
      961 aaattgcagg acaccgatcg tctcactcaa ttctttaaac aaagcctgtg tctcatcata
     1021 atgaccactc ttttccaaca ccacacaatc ctcattcatt tcaaggatac gggcattgta
     1081 cttacggatc agatcctcaa ccgtccccat cttgataaag agttcggtac tcagtttata
     1141 aagagcaatt tcctggtaaa ccaggtcttc atccgtatta taataggctt tcaggatatc
     1201 cacacgcttg tcgatctgtt ttacgacctt gtcgatcgta tcctcgtcgg caaaggtagt
     1261 aattgtaaac ttatgtattc cctttatagc agagggagaa acagaaagcg tctcaatgtt
     1321 cagttgccgg cgcgtaaaga taacagttat ctgattcaga agaccaacag tgttttccga
     1381 aaagataata acggtatata attgttttgt attcatagtt tctcctcctt acttatcacc
     1441 caaaatcatg tttgtcacgc ttcctccggc cggaaccatc ggatatacca taccacaagt
     1501 ttccacattg gcaaccaaca tataggcacc atcgtgattc aacatttcag caatcgcctc
     1561 atccaagtct tcccgtttat ctaccgcacg ggaagcaata ccaaaagcct tggctatcgc
     1621 tacaaaatcc ggattcttca tgatggtatt cgaataccgt tcgttgaaga acagctcctg
     1681 ccactggcgt accattccca ggaaatagtt gttaagaacg atgatcttta cattcagatt
     1741 ttcctgcatg atagttccca actcctggat agtcatctgg ataccaccgt cgccggtaaa
     1801 gaaacagacc gtacggtcag gcgctcccag cttcgctcca atggcggcgg gaaggccaaa
     1861 gcccatcgtt cccaaacctc ctgaagtaac tacgctgcgt gtttgtttat atttgaaata
     1921 gcgaacaccc atcatctggt tctgacctac atccgtaacc agaatcgcat cattatcggt
     1981 tgcttcggaa accttacgga ctacttcgcc cattttcagt tggccttcgg taggatagag
     2041 ttctttttct attaccttat tatattcctc tttttcatcc ggttcgaatt cagcattcca
     2101 ttccggacgc ttccgttctt ccagtaaagc cgtaatcatc ggaatcgtat gcttggcatt
     2161 tcccagcact ttcacgtcga ccggcacatt ctttccgatc tccgaattgt cgatatccag
     2221 gtggataatc tttgcctgct tggcataagt cttcaagtcg ccggttacgc gatcatcgaa
     2281 acgcataccg atagcaatca gcacgtcaca ttcgttagtc ttgcggttcg gtccgacatt
     2341 tccatgcatc cccaacatac ctttatttaa tgggaagtcc gaaggtaatg cagacaagcc
     2401 caatacggta gaaccggctg gtatatcgtt tttcaacaag aattctttca gttcttcttc
     2461 agctcctccc aggataaccc cctgccctac cagacagaat ggctttttgg cattatttat
     2521 caatgaagca gccgcctcga tacgttcctc cctgatatcc ggttcaggct ggtaactacg
     2581 aacataatcc actttctgat actcataatc taccaaaccc acctgtgcat ctttcgccaa
     2641 atccagtacc acaggtcccg ggcgaccggt cgatgcgata tagaaagcac gggaaacggc
     2701 ccaagcaatt tcttccgggc ggcgtatctg gtaagcccat ttggtaatcg gttgtgtgat
     2761 accaattaca tcaacttcct ggaaagcatc tgttccaagc agcggagacg gaacctggcc
     2821 ggcaatcacc accatcggtg tactgtccat cagcgcatcg gcaataccag tgatggtatt
     2881 ggttgccccg ggacccgaag taaccaccgt tactcccact tttccggaaa cacgggcata
     2941 tccctgtgca gcatgtgttg caccttgttc gtggcgcacc agaatatgtt ttaactgatc
     3001 tctgtaatcg tataaactat cgtaaattgg tatcgcctgc ccacccggat aaccgaagat
     3061 agtatctact ccttcagcga tcagcgcttt cagcaaagct tccgaaccgg ttatcttttg
     3121 tttgtccatc tctaaaatat agtatttggt gtttattaat cttctactat tcgtacaccg
     3181 cccttatcgg ccgaagcaac catctttgca tatgctttca gtgctttcga taccgtacgt
     3241 tggcggaaag gaggtgtaaa ggcttttgtt ccgcgggctt cttccgcttc acggcgtttg
     3301 gccagttctt cgtctgtcac ctttacatgt atggttcttt cgggaatatt aatttcgata
     3361 atatcgccgt ctttcactaa gccaatcgct ccgcctgcag ccgcttcggg agaaatatgt
     3421 ccgattgaca aacccgatgt tccaccgctg aagcgtccgt ctgtgattag cgcacattct
     3481 ttacccaggt gtttactctt tatataagaa gtaggataca acatttcctg catacccgga
     3541 ccacccttag gaccttcata ggtgataacg acgacatcgc cggagacgac tttatctttc
     3601 aggatacctt cgcaagcggc atcctgcgaa tcgaatactt tggcagggcc ggcaaaacgg
     3661 aagatacttt catctacccc ggctgtttta accacacaac cgtcctgtgc aatatttcca
     3721 tacagaacag ccagaccgcc gtctttcaca taagcatgtt ccacatcgcg gatacatccg
     3781 gttgcacggt cggtatccag ttctttataa taactttcct gcgatccgag caccaggttg
     3841 aaacggtggg ccggagcact tttataaata ttgattgctt cttccgttac atttacagag
     3901 gtaatgcagt attggtcgat agcctcattc aaagtcagac catccgcacg tttcacggaa
     3961 ccgtccacca gacgggcttt taccagctca ttcataatac cgatgatacc tccggcacgg
     4021 ttcacatctt ccacatgata agaacaactc ggagccactt tacagataac cggtgtttta
     4081 cgtgaaagca tatcgatgtc tttcattgta aaatcgactt ccgcttcatg agccacggcc
     4141 aacaggtgaa ggactgtatt cgtcgatccc cccatggcaa tatccagcga catagcattc
     4201 agaaaggcct gccgggtggc aatactgcga ggcaatacgg aatcatcgcc gtcacgataa
     4261 tatttaaagg cattatcaac aatcatcttc gcggcttttt tgaacaggcg ggtacggttg
     4321 gcatgtgttg caacaactgt tccgttgccg ggaagagcca atccaatcgc ttcgttcaga
     4381 cagttcatag agttagccgt gaacatacca gaacagcaac cgcaggtcgg gcaagcggaa
     4441 cgttccacct tttctacttg ttcatcgctg atagaatcgt cagccgcttc aatcatggcg
     4501 tcgatcaaat cgagtgcacg tccgtccaga ttaccggctt ccatcggacc gccggataca
     4561 aagattgtcg gaatattcag acgcatactg gccatcagca tacccggagt aatcttgtcg
     4621 cagttactga tacaaaccat tgcatcagcc ttatgcgcat tcaccatata ttccacactg
     4681 tcagcaatga tgtcgcggga aggcagagaa taaagcattc cgtcgtgtcc catagcaata
     4741 ccgtcatcaa tagcgatcgt attaaattct gcggcaaagc aaccgagctt ttcgatttcc
     4801 gcttttacct gctgtccgat ctcgtgtaga tgcacatggc ccggtacaaa ctgggtaaat
     4861 gaattcacaa tggcaatgat cggtttaccg aactgttctt ctttcatgcc gttggcacgc
     4921 cataatgcac gggctccggc catacgtctg ccttctgtgc tataggagct tcttaacgga
     4981 ttcttcatca tatctgtttt tatcttttag tcaataaaaa agcccttctc tatatggaga
     5041 aaggcttaag aaatatcttt tacgacttca caacttctta cacacctttc tccttaccta
     5101 ctaatgacta gaaggaccac cacgagaata atatgtaata cattgttcat catcttttct
     5161 tatcgtcttt attttgtttg acgctgcaaa tgtagaataa taatttgtac gagcaaagga
     5221 tttaaaagaa aaatcttact ttttctttca tttatcaata aaagagggcg gttcatcttg
     5281 cattttaaca gataaccagc cctcaatcaa ttgaattctt atttctgagc ctccattcgc
     5341 ttcatattcg ataatttccg gtcattctcc tttactgata cgattgttca gttctttcaa
     5401 caaagcatac gatttcggag aaatcgttcc atcctgataa atccggacat taatcatcgg
     5461 aagatttttc cgcttgttag attctttcac tacctgcgtc aattcgtcaa tggaaagaac
     5521 aggatcaccg ataatggaat ctttataaat gtgcgtccag tcacccggct ccaatgttcc
     5581 ggagaaagtt gcctgtaagc catcctgagg gccaccgtga aacaatccgt ccccatccaa
     5641 cggaagagaa ggatcgttaa caccggcact ggccaaagac aaacccagtt cgccagcata
     5701 ataatcctga aagtccgtca gtttcggcaa tatccaggaa ttaaaacaaa tcgccaactc
     5761 cttatttcca cttttggcgg cttcagcaat cttttcaaac gaggcaccgt taggataata
     5821 accgataccg tcatccatcc acaaaccggc cagacgattt ccataccgct ggctaatctc
     5881 tcccactatc ttttccacat ttgtaaacaa atctcctgca ttatcacgtg tataatgctg
     5941 cttgtcccac cattctttat ctccatgacc gacatggtaa tacagaatca gacgaatgcc
     6001 gtatttaccc aacgcnnnnn nnnnnccact aaatctctct ttgtggtacg ccccggcaaa
     6061 atagaatcga ttgcctgtat cggagccggg aaataatatt ccgcccacga cgttgtaaaa
     6121 aatatcaact tcccgccaca ttcgtaaacg gttcgtgcaa agcggtccac atcaaagtta
     6181 ttgaccgcat cctcataggc taacggctct cctgactgag gcatactctt tgaattccag
     6241 tggaagaaaa agccataagg caaatccgcc atccaggatg tattactgcg aagtgatgta
     6301 gcttccgccc gcaaccgctc ataagtctcc ggccgggtga cttccaacga gtacagatac
     6361 acattaaaat catcctgctt accgggtttg ccaatcttta aagataaaac ggaagtcccc
     6421 ttattaaaat gtaaaggacg ggggaaccgg caacgctgcc atccggttgt atttatccgg
     6481 caaataacac tgtccgttcc attggataat accaattctg tttcttcccc atctcccatc
     6541 cggttgacag aaacgatcat ttcagccatg tagtcttcac cgtccgtatt gactttccag
     6601 gaaatcgact gctcggggct tttccagttc tccgcccaga atgctttata aggttcttcc
     6661 gggtaaaatt gttttacacc attattcagt tctccacgaa aaggaatcaa ccggtttatg
     6721 ttcgccgaat ccaggtttaa tgccggcgga tcaaccggat tactgcaagc ggccagacac
     6781 ataacaaaca aagacaaaaa ataaatatat tgctttttca ttcgtatttt acggatatag
     6841 gaagggccaa tccaataata actcagaccg gcccttcatg tattctacat taattatctg
     6901 taatccggat tctgaggtat gttgttattc agaatttcgg tatcaggaat caaccaagta
     6961 ttgttgtaag caccgatagg gacattcaat ctgctgccac gcgctttctg taccttatcg
     7021 aatgtctggg tacgtttcaa atcgtaccag gcaaaaccct cttcatacaa ttcatgctga
     7081 cgttccagca gaacggcttc acggaactgg tcctgagaaa gtccgctcaa gtcaggcacg
     7141 tttgtcgggt cgttctggtc gacacgggca cgtttacgga tagcattgat atattgataa
     7201 gcaccggccg gtccgtttat ctcattttca gcttcggcgg caatcagata catttcagcc
     7261 aaacgaatca attgagtctg ccaggtcaaa atattggtat tagatgctgg caactcctgt
     7321 tccagatact cttcattgat atacttatta taatatgtac gcgcgatgac tttatttcct
     7381 ttcgcattta catattcagg tttaattccc cattctttac gcatatcacc tttatcgaag
     7441 ctggcgataa aagcatctgt cggaagatac aaggctgtct ggctgccaat cggtgaagat
     7501 tcattatgca taccgctata gctatcggga gcggagaaca actgagccca gatagtttca
     7561 gccgtataac gttccgtctt aaatacttta tcgaaggtag gcatcaaaga atactgaccg
     7621 ctgttgatta cttcaagcgc tttctctttg gctttcgcat aattttcttt ctgattcatc
     7681 gggaaaccgg cagaagtcag atagatacgt gccataatcg cttttacgac ccatttattt
     7741 acacgtccca tatcctgcgc ttcttccgga agtttttgtt ccgcatccag aatatcgtca
     7801 aaaataaact gatagatatc agcctgcggc gtacggtcta ttgccacgtc ggcatcactg
     7861 gtcacgactt tatcccgcaa agggacatct ccaaagaact ggaccaatgt aaaataagac
     7921 caggcacgca aacatttcgc ctcaccgata atacgattct tggtttcggc tgtaaaatcc
     7981 ttatcttcta tcgactccaa tatcatattt gcattcttta tcgtactgta tggtccggac
     8041 caggcatttc taaaggcata aaaaccatat cccggattat ttgcccagat atccccgacc
     8101 tgttcagccg attcaggctt atcattatag tcggcaaaaa cttccgtcag attcagattt
     8161 tgtccctgag gatataaccc tttcaaagct ccgtcaaaat cttccaccgt ttgatagaag
     8221 gaagagggag aaataaatgt tttcgggtct tcttccagcc aatcggagca agaagcagac
     8281 agaataaccg gtacagccag caatatattt ttaatcagtg ttttcattct tttcatacgt
     8341 attaaaattt aacctgtaaa cccaaagtaa atgatttcgc agacgggtaa acccctctgt
     8401 cccatccgtt cacggcagaa gacgtccagg atgcttccgg gtcataatga gaatagcttg
     8461 taatcgtaat cagattctgt ccgctcagat aaaccgagat attaggttta cgggaacccg
     8521 cgaaccattg agacggcaac gtataagcca atttgatatc tttgaatcgc agatacgaac
     8581 cgttttccac ccaaaccgaa ctcgggtcac cgaaggccag ataatccttg gtcgcaacag
     8641 aagcacgtgc atatttggca ttcggatttt caggagtcca atggttttcc cagacatctt
     8701 tgcggatatt ccatgtgccg ccgatattag tgatactttt attaaattca ttaacgatat
     8761 caccaccaac actacctatt aacaggaatg ataactcgaa gttattccaa ttgataatat
     8821 tcgtcagacc gaaagtaaac ttaggctgcg tatttgcaat aatcgtttta tcacctgttg
     8881 taataccagc tttcccgtcc gtgtctttat accggtaatc acctgctttc ttggttgctt
     8941 cgccattcaa acgagcttct tcatccgtct gataaatacc ttctatttcg tagccataca
     9001 attggaacgg agctttaccg acaaacagag ggaaccagtt tccgccaccg ataggagcat
     9061 ctatccgctg aatcttattt ccatacacat ccgaacccaa atctttcacg attgatctat
     9121 tggatgtaat attcaaatta gtcgtccagt tcacttttcc tttcatattg attgtattga
     9181 tagatatttc aaaaccttta ttatcaatac gtcctaagtt tctcagcata gaagaatatc
     9241 cggaagacgg gggaagagtc gcattataca gcaagtcacg cgtttgtttc caataatagt
     9301 caaaaccgat attcaggcgg ttggaaaaga atccgaagtc gacacctata tccgtttgtg
     9361 tagttgtttc ccatttcaag tcgtcgtttg ccatggagga caaaccgaaa ccaatatctt
     9421 ttccatcacc gaaaatagga ccggaagttc ccagacgggc gaaagtctga tacgggctaa
     9481 tagattgatt accggtctgt ccgatactgg cacgcagttt cagattgctc agccaatcaa
     9541 tatcttgcat aaaattctct tccgacaaac gccaggccaa tgcggcggaa gggaagaaag
     9601 cgaatttatg gttcttactg aatttagacg aaccgtcata tcgtgcggtg acagtcaaca
     9661 gatatctttc catcaggtta taattggcac gtcccaggaa agaagccatc cggtaatcgc
     9721 tgtaaccgga agacggagtt ccgggtgtag aagctactcc caaattattc gtttcataga
     9781 catcgcgcag aaatcctgta cctgagccgc ccaaatcatt atactgatag gtctggaaag
     9841 taacaccacc catcaggttc aatgcatgat tcttattgaa ccgcttgtcg taggtcaaaa
     9901 tattctcatt aataatagta taataattag attttgactt agacgcatca ccatccaatt
     9961 tacctccggc agacaaacca atcggaatgt accggtcgga actacccgca ttgacttcag
    10021 caccggcatt cacccggaaa gtcaatccgt cgataatctc atagataagc gacatattcg
    10081 ccagtaagcg ggaattaacg gttttattct tatacaattc agccataccg acagggtttg
    10141 ttcctcccca gggagttccc gagaaattgg tgtacttgcc atcggcatct cttatttcct
    10201 gtatcggagc catgaccatt gccgtataag caatcgctcc ccagccatcc gcattactgt
    10261 tcgctgtatt ctgagttccg tatgaataag cgatactggc attcaacgac aaatttctcg
    10321 ccagcttctg gtcgccatta atacgcaatg caaaacggtt ataatcagaa cctttgataa
    10381 taccttcctg gttcatatag ttcagagagg agtacaactt cgttttatcc gtaccgcccg
    10441 agacagacac ctgatgacta tgcgtcaagg cagtctgata agccaggtcc tgccagtcat
    10501 tgttcggcag catagctgct tgctccggtg tgatggcaat accgttcccg tcattctggg
    10561 aaacttcatt taccatggcg atataatcat cttttcccag taaatccagt ttctttctta
    10621 aagaagaaac accgacatat ccattatatt caaggaccgt atcgccggta cgtcctcttt
    10681 tcgtcgtaat cataacgaca ccgttcgcac cacgtgaacc gtagatagcc gtagaagatg
    10741 catctttcaa tacttccatc gacagaatgt cttccgggtt aatatccgaa ttcatctttt
    10801 ctaccggcat accgtcaatg acataaagcg gttcgttacc acctgccagg gagttacttc
    10861 cacggacacg aatcatcatc gattcacccg gctgaccagt tctggcatta acctgcacac
    10921 cggctatttg cccctgcaac gcacggtcgg cactggttat acccacctgg ctcacgtcct
    10981 tcatctgcac ggaaccgaca gctcccgtca agtcgctctt ctttaccgta ccataaccga
    11041 taaccacaac ctcatccaag gcttcggaat cctcgcgaag tgaaacatta acgacatctc
    11101 cgcttccgac ctttacttcc tgggtgttgt aaccgatata agatatctgc aacacaccac
    11161 cttccgggac ttccagacta taccgcccgt tcatatccgt aactgtcccg ttcgttgttc
    11221 cctttacgac tacattcgca ccaataacgg gttcaccggt ttcatccttc acaactcctg
    11281 atatattttt cgttgaagaa acagtacggg cttgcttgtt gataataata tgtccgttac
    11341 tgaacgttat cgaacaaccg gaaccttcca gcaactgttc cataacctct ttcacattac
    11401 tgttctttgg taactttgtc aggacgcgag aatcgtttac ttcctgcgtg ttataatcga
    11461 caaacagttt ggtctgttgc tcgatttgtt tgaaggctgt cttcagtgtt acattgcttc
    11521 cggtcaggcg cacttgttga tgttgcgcat aagaaaataa actgatggaa gataaagctg
    11581 taataaacaa cagcctggat acactttttc cgttatttat acgtattaga ttagttaatt
    11641 tcatatattt gtacatttga aaattgaata ttaataaaac catgacgatt tactcgtcaa
    11701 tccaaagatg ttcaagattc gatttcgaat tccggaaaga gggattttcg cactttctgt
    11761 ctttccggtt ttcttttgtt catatttgtt tactcctata ttttagttta taaataccac
    11821 ctttcctttt attttataat gtataccaat cagttgttgc agaatgttca gcacatctta
    11881 cagcttttca tccggcgaga atttgacatt ataatattct cccgcaaact tttgggaatt
    11941 ataatgaatc gtcacattga acttacgttc caaagaggcc atcagacggc tgaaagatgt
    12001 attttcaaat atcagatagc cgtttctttc catattatat aaggaagcgt cgatagaatg
    12061 gaccatcacg gtatgttctg aatgcgaata aaccaactgt tggtcaggct ttagcacagt
    12121 cggctgaatg tcttcattcc taacagatac cagtacactt ccttcctcca atgttgccat
    12181 ggaacaggag tcgcccggat aagcctccac ggtaaagaca gtacccaacg cctggacatc
    12241 aaggtaagtc gtcttcacaa caaagggttg ctccggattc ttacggacag agaaggatgc
    12301 ttgcccggtc aggtaaaccg ttcgtgtatc agtatcggta aaatctttcg gataaaccaa
    12361 cagcgtaccg gcatctaccc acaccttcga accgtcaggc aataccacct gctcactttc
    12421 tccgtaaggg acgaatacct gtgccatttc cacatgacgg accggtttaa aacggtcggt
    12481 tgcccaatag gtcgttccgg cagtcatcat catcaagaca ataacggccg catatttcaa
    12541 ccactggcga tagaatggca ccgaacgttc acgaacgggg agcacggaaa gatgcctttg
    12601 caaagccttc caatcactat gggtagaatc cgtcacctcc ggctgagatt tcttccacaa
    12661 atcctgcaac atttcttcct tctccgtttt tgcatcgtcc gccttcaacc aacgcccaaa
    12721 caagatacgt ccatatcggg aaaagtgctt tccgaagtag agctgcatga gttgttttat
    12781 cttgttgttc tcttccataa aatatccgtc tttatatgga tgtaggttta tgacaacaat
    12841 acacacaatc aaaaatcaac tttttttgaa aatagtttga ttccggtact aacgggtgct
    12901 atcgttgaat gtgtttcata gtaatgaaac agttgtttct atatgatgga acacttgttt
    12961 cattaagatg aaacactttt ggggaacggc agtgctcagc ccaaactggt aaacaaaaaa
    13021 agataaagaa ccttacgaag aatggacagg gcagcagtca aatggttttc gactgtacgt
    13081 ttactgattc ccaaacgggt ggcgatctca tcattcgata aaccctgctc acgactcatc
    13141 ttataaatta gctttcgttg aggagacatt tgttcgacag tccggttgat aaggttttgc
    13201 aattcacgtg caaacatcgc ttcctcttcc gattgggaga tggaggcttc cagtaaaaac
    13261 tcattggtat acttttctga aacggcaaga cggtcgaaat aatcataaac ggtaaagcgc
    13321 gccatctgaa agagatagga ggaaaaagaa cggacgtctt tcagtttttc ccggtctttc
    13381 catatggaaa gaaacaaatc ctgggatata tcacgactga tttccttgtc gtgcgtcagg
    13441 ccgacaagga aatataccaa cctaggttgg tagtcgaaaa aaagctgttc aaaagctttt
    13501 atgtttcctc ttgcgatctc cctcaagata tgttgctcct ctggtaattc cataactagt
    13561 gcgaagtaac aaaaaatatc agaaataaaa ttatttactt tgataaattc atagaaaaca
    13621 cgggaacata aactaccttt gtcttatctc gtaagcataa ataaaaaaac aggagtaatt
    13681 attatggaag ttgcaaaaag aatcccttac ggcatttcca attttgtgga agtggtggag
    13741 cagaaccagt attatgtgga taagacgatg tatttgccta tgctggaaga gcaacccagt
    13801 aatttgtttt tcatccggcc ccggcgtttt ggcaagagca tctttctgag tatgctccgg
    13861 gcctattatg atattgctca aaaagagaag tttcaaaaac gtttcggcaa tttgtggata
    13921 ggagagcatc ccaccccttt acaaggaaca tttcaagtac tttatttgga tttctcacgt
    13981 gccagtggcg gcagtggttc actatcagag aactttgacc ggtattgcag tatggtgatg
    14041 gatatgttcg gcatgtctta cgagtcttat tattatccgg ggtttgccaa tgaaatgaaa
    14101 gcattgcccg attttgtcag caaactgaac tatttgaatc ttcatgcacc cgaaaccggg
    14161 gcgcatctct atcttattat cgacgaatat gataacttca ccaatataat actcaatgag
    14221 caaggtaatg acgtttacca tgctctcaca catgccagcg ggttctatcg cgagattttc
    14281 aagaaattta aaggaatgtt cgaacgtatc ttcatgaccg gcgtcagtcc tgttacattg
    14341 gatgatctta ccagcggatt taatatcggc tggaacatca gcaccgaaca tcaattcaat
    14401 atgatgctag gattcagtga agtagacgta cgctctatgt tccagtatta taaggatgca
    14461 ggacaactgt cggatgatgc agatatagag gcaatgatta cggagatgaa accgtggtat
    14521 gacaattatt gttttgcaaa agaaagcctg aaaagtgacc cgaagatgtt caattgcgac
    14581 atggtactct actatctccg caattacata accttgaaaa aatctcccga acagatgata
    14641 gaccccaata cccgtacgga ttataacaaa atgaagaaac tcatccagct ggaccgtctg
    14701 gacggtgacc gaaaaggggt actgcgtaaa atcactgatg agggacaaat cgttactaat
    14761 ctggcaatca cttttcctgc aacagagatt gccaatccgg aaatcttccc cagtctgctt
    14821 ttttattatg gtatgctgac tattaccaat acccgcgggg ggcgtgtggt attaagtatc
    14881 cccaacaaca atgtgcgcaa gcaatat
//
