LOCUS       c00186_gnlPro..        15041 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KOJBBOEO_186.
ACCESSION   c00186_gnlPro..
VERSION     c00186_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 19:01:05
            Original ID  :: gnl|Prokka|KOJBBOEO_186
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15041
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..105)
                     /locus_tag="ctg186_1"
                     /transl_table=11
                     /translation="MAQLNFGGTVENVVIRDEFPLEKAREVLKNETIAV"
     protocluster    1..15041
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[911:5041]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      912..5041
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..15041
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15041
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(169..912)
                     /locus_tag="ctg186_2"
                     /transl_table=11
                     /translation="MSEENKIGTYQFVAEPFHVDFNGRLTMGVLGNHLLNCAGFHASDR
                     GFGIATLNEDNYTWVLSRLAIELDEMPYQYEKFSVQTWVENVYRLFTDRNFAVIDKDGK
                     KIGYARSVWAMINLNTRKPADLLALHGGSIVDYICDEPCPIEKPSRIKVTSNQPVATLT
                     AKYSDIDINGHVNSIRYIEHILDLFPIELYQTKRIRRFEMAYVAESYFGDELSFFCDEV
                     SENEFHVEVKKNGSEVVCRSKVIFE"
     CDS             complement(912..1475)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg186_3"
                     /sec_met_domain="ALS_ss_C (E-value: 7.7e-20, bitscore:
                     60.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDKTLYTIIVHSENIAGLLNQVTAVFTRRQINIESLNVSASSIK
                     GVHKYTITAWTDKDTIEKVVKQIEKKIDVIQAHYFTEDEIYFHEIALYKVSTPAFQETP
                     EASKVIRRYNARIVEVNPVFSIVEKNGMSEEITSLYEELRALKCVLQFVRSGRVAITTS
                     CFERVNEFLDGQEAKYKQSKKEQE"
     CDS             complement(1494..3191)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg186_4"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.3e-47, bitscore:
                     150.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKDLITGAEAMMRSLEHQGVTTIFGYPGGSIMPTFDALYDHQNT
                     LNHILVRHEQGAAHAAQGYARVSGKVGVCLVTSGPGATNTITGIADAMIDSTPIVVIAG
                     QVGTGFLGTDAFQEVDLVGITQPIAKWSYQIRRAEDVAWAIARAFYIASSGRPGPVVLD
                     FAKNAQVEKTKYEPTQQEFIRSYVPVPDTDEESVKAAAELINNAERPLVLVGQGVELGS
                     AQEELRIFIEKADMPAGCTLLGLSALPTDHPLNKGMLGMHGNLGPNINTNKCDVLIAVG
                     MRFDDRVTGNLATYAKQAKVIHFDIDPAEVNKNVKVDIAVLGDCKKTLAAVTGLLKKNR
                     HTEWVDSFKEYEAVEEEKVIRPELHPATDSLSMGEVVRAVSEATRHEAILVTDVGQNQM
                     ISARYFKYTRERSIVTSGGLGTMGFGLPAAIGATFGRPDRTVCVFMGDGGLQMNIQELG
                     TIMEQKAPVKIICLNNNYLGNVRQWQAMFFNRRYSFTPMLNPDYMKIASAYDIPSKRVF
                     SREELKVAIDEMLSTDGPFLLEACVVEEGNVLPMTPPGGSVNQMLLEC"
     CDS             complement(3239..5041)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg186_5"
                     /sec_met_domain="ILVD_EDD (E-value: 5.1e-218, bitscore:
                     714.6, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKQLRSSFSTQGRRMAGARALWAANGMKKNQMGKPIIAIVNSFT
                     QFVPGHVHLHEIGQLVKAEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLID
                     AMIKSADDSVSDQEVANIEQNACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     ENRTKLFEDAAKLIVENAMKYYEEGDESVLPRSIATRQAFLNAMTLDIAMGGSTNTVLH
                     LLAVAHEAGVDFKMDDIDMLSRKTPCLCKVAPNTQKYHIQDVNRAGGIIAILAELAKGG
                     LIDTSVLRVDGMSLAEAIDQYSITSPNVTEKAMSKYSSAAGNRFNLVLGSQGAYYQELD
                     KDRANGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQEA
                     ACEGILGGRVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGG
                     TSGLSIGHVSPEAAAGGNIGKIVDGDIIEIDIPSRTINVRLTDEELAARPMTPVTRDRY
                     VPKSLKAYASMVSSADKGAVRLID"
     CDS             5355..5930
                     /locus_tag="ctg186_6"
                     /transl_table=11
                     /translation="METVENKYITVAYKLYTVEDGEKELFEETNAEHPFQFISGLGTTL
                     ESFENQITALSKGDKFDFTIPADEAYGAYDEQHVFDLPKNIFEIDGKFDSERVTEGSIV
                     PLMTGDGQRVNASVVEIKPDVVVVDLNHPLAGADLIFEGEVIESRPATNEEIQELVKMM
                     SGEGCGCGCDSCGSDCGDDCGCEGGHCH"
     CDS             complement(6069..7358)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SDH_alpha"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg186_7"
                     /sec_met_domain="SDH_alpha (E-value: 1.2e-62, bitscore:
                     201.8, seeds: 645, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIESERKQIIDLIKKEVIPAIGCTEPIAVALCVAKAAETLGMKPE
                     KIEVLLSANILKNAMGVGIPGTDMVGLPIAVALGALIGRSEYQLEVLRDCTPEAVEQGK
                     LFIAEKRICISLKEDITEKLYIEVICTAGSQKATAVIAGGHTTFVYIATDEKVLLDKQQ
                     TANEEEEDASLELNLRKVYDFALTSPLDEIRFILDTARLNKAAAEQAFKGNYGHSLGKM
                     LRGTYEHKVMGDSVFSHILSYTSAACDARMAGAMIPVMSNSGSGNQGISATLPVVVFAE
                     ENGKTEEELIRALMLSHLTVIYIKQSLGRLSALCGCVVAATGSSCGITWLMGGNYNQVA
                     FAVQNMIANLTGMICDGAKPSCALKVTTGVSTAVLSAMMAMEDRCVTSVEGIIDEDVDQ
                     SIRNLTRIGSQAMNETDKMVLDIMTHKGGC"
     CDS             7492..8577
                     /locus_tag="ctg186_8"
                     /transl_table=11
                     /translation="MKAKHGILYLLLAIFSSSCIREEAPNAEADILSCRLPGVVMTTSP
                     IITNNSINIFVGPGTDISSLAPEFTLTPGATIDPPSGTARDFHSPQQYTVTAADGFWKK
                     KYTVSVIDTELATIYNFEDTLGGQKYYIFVEREGEKVVMEWASGNAGYAMTGVPKTADD
                     YPTFQFANGKTGKCLSLVTRSTGFFGSIMGMPIAAGNLFIGSFDVGNAMSNPLKATKFG
                     LPFRHIPTYLAGYYKYKAGDQFTEGGKPVSGKRDICDIYAIMYETSESVPTLDGTNAFT
                     SPNLVSIARIDDAKETDEWTYFKLPFHMLSGKYIDKEKLTAGKYNVAIVFTSSLEGDHF
                     NGAIGSTLLIDEVELIYRSED"
     CDS             8668..9453
                     /locus_tag="ctg186_9"
                     /transl_table=11
                     /translation="MKIHSYIFSLLACLVIALPGYSQVDRNETLIRSALHGLEYEIKAG
                     FSIGGTAPLPLPVEIRSIDGYNPTLAISIGGEVTKWFAVQNKLGVIVGLRLENKAMTTE
                     ATVKNYNMEILGQGGERISGVWTGGVKTKVHTSGLTIPLMATYKLSNRWNIKAGPYFSY
                     LLSREFSGHVYEGYLREGDPVGPKVEFTDGKIATYDFSDDLRHFQWGLQIGAGWRAFKH
                     LNIYADLTWGLNDIFRNDFQTITFAMYPIYLNIGFGYAF"
     CDS             complement(9469..10032)
                     /locus_tag="ctg186_10"
                     /transl_table=11
                     /translation="MKKNLLYLWALICSVSLLTACSSDDDNTVNDETTPPEEEAVVTAP
                     DVVGTYWGNLDISMLPDGSDQEVVIADGLPKFITFSQVSDTEVKMELKEFELFINGNIL
                     KFGDIVIDKCAVKKETDASTFTGQQDLTFQGDAAALGTCATSIEGTVQGGNATMNIQVK
                     VPALQQTVKVAFSGVKQVEESGKD"
     CDS             10191..11267
                     /locus_tag="ctg186_11"
                     /transl_table=11
                     /translation="MFNSFGNIFRLTSFGESHGKGVGGVIDGFPSGITIDEEFVQQELN
                     RRRPGQSILTTPRKEADKVEFLSGIFEGKSTGCPIGFIVWNENQHSNDYNNLKEVYRPS
                     HADYTYKVKYGIRDHRGGGRSSARETISRVVAGALAKLALRQLGISITAYTSQVGAIKL
                     EGTYSDYDLDLIETNDVRCPDPEKAKEMADLIYKVKGEGDTIGGTLTCVIKGCPIGLGQ
                     PVFGKLHAALGNAMLSINAAKAFEYGEGFKGLKMKGSEQNDVFFNNNGRIETHTNHSGG
                     IQGGISNGQDIYFRVVFKPIATLLMEQETVNIDGVDTTLKARGRHDACVLPRAVPIVEA
                     MAAMTILDYYLLDKTTQL"
     CDS             11369..12733
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M20"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg186_12"
                     /sec_met_domain="Peptidase_M20 (E-value: 1.1e-38, bitscore:
                     122.9, seeds: 360, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNEIQKYIAANEPKIMEDLFSLIRIPSISALPEHHDDMLACAQRW
                     AQLLLEAGVDEALVMPSKGNPIVFAQKIVDPNAKTVLVYAHYDVMPAEPLELWKSQPFE
                     PEVRDGYIWARGADDDKGQSFIQVKAFEYLVKNELLKNNVKFIFEGEEEIGSPSLEAFC
                     EEHKELLKADVILVSDTSMLGAELPSLTTGLRGLAYWEIEVTGPNRDLHSGHFGGAVAN
                     PINVLCEIISKVTDKDGRITAPGFYDDVEEVPQAEREMIAHIPFDEKKYKEAIGVKELF
                     GEKGYSTLERNSCRPSFDVCGIWGGYTGEGSKTVLPSKAYAKVSCRLVAHQDHHKISQM
                     FADYILQMAPDTVQVKVTPMHGGQGYVCPISLPAYQAAEKGFEIAFGKKPLAVRRGGSI
                     PIISTFEQVLGTKTVLMGFGLESDAIHSPNENFSLDIFRKGIEAVIEFHQEYAKR"
     CDS             complement(12859..13917)
                     /locus_tag="ctg186_13"
                     /transl_table=11
                     /translation="MKKKLTGVALVLAAVSLMGIQPAEACTRAVYLGPDGMVVTGRTMD
                     WKEDIMSNIYVFPRGMQRAGHNKEKTVNWTSKYGSVIATGYDIGTCDGMNEKGLVASLL
                     FLPESVYSLPGDTRPAMGISIWTQYVLDNFATVREAVDEMKKETFRIDAPRMPNGGPES
                     TLHMAITDETGNTAVIEYLDGKLSIHEGKEYQVMTNSPRYELQLAVNDYWKEVGGLQML
                     PGTNRSSDRFVRASFYIHAIPQTADAKIAVPSVLSVMRNVSVPFGINTPEKPHISSTRW
                     RSVSDQKNKVYYFESTLTPNLFWLDLKKIDFSPKAGVKKLSLTKGEIYAGDAVKDLKDS
                     QSFTFLFETPVM"
     CDS             14158..15033
                     /locus_tag="ctg186_14"
                     /transl_table=11
                     /translation="MRMRQKVSISRLPIRLGIFLLLYFVPQLLSAQENNDSTHILRNGA
                     SITPDDVLKQANINLFPEKSTTYSLYSPGQLEHIPRFSLKRDISLPYQTNPSLLFRGDY
                     STGGVLHQFDHGALFGSGSQTSMAGIGRFNSASLGYQHIFNEQFELQVRANALKVNMSH
                     ITGQAFSTSGAFLYHPSDHVTFKVFGSYDIGNSYGMSTHSYGATMSVDMSDRFGMEMGV
                     QRYYDAMSGRWETVPVMIPYYHFDKFTLGLDVGGIIYEILRNAVFDKNRGIGGPSGPTI
                     GPPRMHIPIR"
ORIGIN
        1 tacagcgatt gtttcatttt tcaatacttc acgagctttt tccaatggaa attcatcacg
       61 gataactaca ttttctacag ttccgccaaa attcaactgt gccatttttt ttgttttttt
      121 gttttgatga cttgcgccat ctgttattaa ttgattttat actctatatt attcaaatat
      181 cactttggaa cggcatacta cctcgctgcc gtttttcttc acctctacat gaaactcgtt
      241 ttcactcacc tcatcacaga agaaagagag ttcatctccg aaataacttt cagccacata
      301 cgccatttca aaccggcgga tacgtttcgt ctgatacagt tctatcggaa acaagtcaag
      361 tatgtgctcg atataacgaa tactgtttac gtgtccgtta atatcgatat cactgtattt
      421 tgccgtcagc gtcgcaacag gctgattgct tgtcaccttg atacgcgaag gcttttctat
      481 cgggcagggt tcatcgcata tataatcgac gatgcttcct ccatgcaatg ccaacagatc
      541 ggcaggctta cgggtattca gattgatcat cgcccatacg gaacgggcat agccgatctt
      601 ctttccatcc ttgtcaatga cggcaaagtt acggtcggta aagagacgat agacattctc
      661 cacccatgtc tgaaccgaga acttctcgta ctggtaaggc atctcatcca gctcgatagc
      721 caggcgggaa agcacccatg tgtaattgtc ctcgttcagc gtagcaatac caaatccacg
      781 gtcgctggca tgaaaacctg cgcaattcag cagatgattt cccagcacgc ccatggtcag
      841 gcggccgtta aaatctacgt gaaacggctc tgccacaaac tgataagtcc ctattttatt
      901 ttcttcactc attactcctg ttccttttta ctttgcttat acttcgcttc ctgtccgtcc
      961 aggaactcat tcacacgttc gaaacagctg gtagtaatag ccacacggcc cgaacggaca
     1021 aactgcagca cacatttcaa agcccgaagt tcttcgtaaa gggaagtaat ctcttcactc
     1081 atgccgttct tctcgacgat agagaatacc ggattcacct ctacaatgcg ggcattatat
     1141 ctgcggatca ctttagatgc ttccggagtc tcctgaaaag caggagtaga taccttatat
     1201 aaggctatct catggaaata aatctcgtct tcagtaaaat agtgcgcctg aatcacatca
     1261 atcttctttt cgatctgctt caccaccttt tcaatagtgt ccttatcagt ccacgctgtg
     1321 atcgtatatt tatgtactcc tttaatggaa gaagcagaaa cgttcaaact ctcgatgttt
     1381 atttgccgac gggtaaatac agcggtcacc tgatttagca atccggctat attttcagaa
     1441 tgaactataa tcgtatataa tgtcttatca ctcataactt tctaaattaa ggattaacat
     1501 tccagcaaca tctgattgac tgaaccgccc ggaggggtca tcgggaggac attgccttct
     1561 tctaccacac aggcttcgag caggaacggc ccgtctgtcg agagcatttc gtcgatagcc
     1621 actttcagtt cttcccgtga aaagacacgt ttggaaggaa tatcgtaggc ggaagcgatt
     1681 ttcatgtaat ccggattcag catcggagta aatgaataac ggcgattaaa gaacatagcc
     1741 tgccattggc gcacgttgcc gagataattg ttgttcaggc agataatctt caccggagct
     1801 ttctgttcca tgatcgtacc cagctcctga atgttcattt gcagtccgcc gtcacccata
     1861 aatacacata cagtgcggtc gggacggccg aaagtagctc cgatagctgc cggaaggcca
     1921 aaacccatcg tgccgagtcc acccgaagta acgatactac gttccctggt atatttaaag
     1981 tagcgggcag agatcatctg attctgacct acatctgtca ccaatatggc ttcgtgacgg
     2041 gtcgcttcgc ttaccgcacg caccacttcg cccatactca gtgaatccgt tgcaggatga
     2101 agttcgggac gaatgacttt ttcttcttct accgcttcat attccttgaa actatcgacc
     2161 cactcggtgt gccggttctt tttcaacagt ccggtcacag cagccagcgt ctttttgcag
     2221 tcgcccaaaa cggcaatgtc tacctttaca ttcttattta cttccgccgg atcaatgtca
     2281 aaatggatca ctttcgcttg tttggcgtaa gtagccagat taccggtcac acggtcgtcg
     2341 aaacgcatac cgacagcaat cagtacatca catttgttag tattgatatt cggtcccaga
     2401 tttccgtgca tacccagcat tcctttattc aacggatggt cggtaggcaa tgcggaaagt
     2461 ccgagcaagg tacaacctgc gggcatatcc gccttttcga taaagatacg cagttcttcc
     2521 tgagcgcttc ccagttccac tccctgtcct accaagacaa gcgggcgttc ggcgttattg
     2581 atcagttcgg cggcagcctt tactgattct tcgtctgtat cgggaaccgg aacatagctg
     2641 cggataaact cctgctgcgt cggctcgtat tttgtttttt caacctgcgc attcttggca
     2701 aagtcgagta ccaccggacc gggacgacca ctactggcaa tgtagaaagc acgtgctatc
     2761 gcccaggcta cgtcttcggc acggcgaatc tgatagctcc atttagcgat tggctgagtg
     2821 atacctacga gatcgacttc ctgaaaagcg tctgttccaa gaaagcctgt tcccacctgt
     2881 cctgcaatga caacgatagg cgtactgtct atcatcgcat ctgcaatacc tgtgatcgta
     2941 ttggttgctc cggggccgct tgtcaccaag caaacaccga ctttacccga tacacgggcg
     3001 tagccttgtg ccgcatgggc agctccctgt tcatggcgaa ccaagatatg gttcaatgta
     3061 ttttgatggt cgtacagggc atcgaacgta ggcatgatgg aaccgccggg ataaccgaaa
     3121 atggtagtca ctccctgatg ttccagagag cgcatcattg cctctgcgcc tgttattaag
     3181 tccttactca tagttcttta atggataatg gatgattcat aatggataat gaagtggatc
     3241 agtctattaa tctcactgct cccttatcgg cagagcttac catgctggcg tatgctttca
     3301 ggctcttcgg cacgtaacgg tcacgggtga cgggagtcat cgggcgggca gccagttctt
     3361 catctgttag tcgcacgtta atcgttcggg agggaatgtc gatttcgatg atatctccat
     3421 ctactatttt tcctatatta cctccggcag cggcttcggg agaaacgtgt ccgatactca
     3481 atccggaagt tccaccactg aaacgtccgt cggtaatcaa ggcacattct ttgccgaggt
     3541 gacgggattt gatataagaa gtcgggtaaa gcatttcctg cataccggga ccgcccttcg
     3601 gaccttcgtg cgtgatgacg acaacgtcgc cgctgacgac tcggcctccg aggatgcctt
     3661 cacaggctgc ttcttgtgag tcgaatactt tggcaggtcc ggtaaacttc cagatgcttt
     3721 cgtctacacc cgccgttttt actacgcaac cgtcctgagc gatatttcct ttcagtaccg
     3781 ccaggcctcc gtccttgcta taggcgtgct ccagatcacg gatacatccg ttcgcgcgat
     3841 ctttatctaa ttcctgataa taagctccct gagaaccaag tacgagattg aatctgtttc
     3901 ctgccgcact tgaatatttg ctcattgctt tttccgtaac gttcgggctg gtaattgaat
     3961 attgatcgat cgcttccgcc agcgacatgc catccacacg gagaacggaa gtatcaatca
     4021 gaccgccttt tgccaactct gccaggatag caatgatgcc acccgcacgg ttaacgtcct
     4081 gaatatgata tttttgagta ttcggagcga ctttacacag gcagggtgtc ttgcgtgaca
     4141 gcatatcgat gtcgtccatc ttgaaatcga ctcctgcctc atgtgccacg gccaacaggt
     4201 gaagcaccgt attggtagaa ccgcccatcg caatatccag cgtcatggca ttgaggaatg
     4261 cctgacgggt agctatgctg cggggaagta cactttcgtc accttcttca taatatttca
     4321 ttgcattttc cacaatcagt ttggcagcat cttcaaacag tttcgtacga ttttcgtgcg
     4381 tagccacgat tgtgccgttt cccggaagag ccaagccgat agcttcattc agacagttca
     4441 tcgagtttgc cgtaaacatt ccggaacaac atccgcaggt aggacaggca ttctgttcga
     4501 tattcgctac ttcctgatcg cttacactgt cgtccgccga tttaatcatg gcatcgatca
     4561 agtccagatg ctgaccgttc cactctccgg cttccatcgg tccgccggat acaaatacgg
     4621 tagggatatt caggcgcatg gccgccatca gcatccctgg ggtaatctta tcgcagttgc
     4681 tgatacatac cattgcatcc gccttgtgcg cattgaccat atattctacg ctgtccgcta
     4741 tgatatcacg ggaaggaagc gagtaaagca ttccgtcatg tcccatagcg ataccgtcat
     4801 caatagcaat cgtattaaat tccgcagcga agcatcccag cttctcaatt tccgccttca
     4861 ccaactgccc gatttcatgc aggtgcacgt gtcccggaac aaattgtgta aacgaattga
     4921 cgatagcgat aatgggtttt cccatctgat ttttcttcat gccgttggct gcccataatg
     4981 cgcgggctcc cgccatgcga cggccttgtg tactaaacga actgcgtaat tgctttttca
     5041 tttcaatcta tcatatcttc ttttctttat tttcgtgctg caaaggtaag ggctttttta
     5101 ttatctccaa acaaatcgaa gaaaaaaatc actaaaaagc gaataatcgt aagaaaagaa
     5161 cggtaataaa cctaaatttt atcacttaaa ggttgaattt gcaactatca gttagtagag
     5221 aatgactgtc catttctgac aaaagcgctt aataatctga aatttactcc gtatgcaccc
     5281 ggtagcaagc aaattattcg tatctttgtc caccctaaat aagggattta ttaattagaa
     5341 actataaata tcagatggaa acagtagaaa acaagtacat caccgttgca tataagctat
     5401 atacagtgga agatggtgaa aaagaattgt tcgaagaaac aaatgcagaa catccttttc
     5461 agttcatttc aggattaggc acaacgctcg aaagcttcga gaaccagata acagctcttt
     5521 ccaagggtga taaattcgat tttaccattc cggcagatga agcttacgga gcctacgatg
     5581 agcaacatgt atttgatctt cctaaaaata tctttgaaat agatggcaag ttcgacagcg
     5641 aacgcgtaac agaaggcagc attgtacctt tgatgaccgg agacggtcaa cgcgtaaacg
     5701 ccagcgtcgt agaaatcaaa ccggatgtag tagtagttga ccttaaccac ccattggcag
     5761 gcgctgacct gatctttgaa ggtgaagtaa tcgaaagccg tcctgctacc aacgaagaaa
     5821 ttcaggaact ggtgaagatg atgagcggtg aaggttgcgg ttgcggatgc gacagctgcg
     5881 gcagcgactg tggcgatgac tgcggttgcg aaggcggaca ctgccactaa ttttaagtaa
     5941 taggtaataa gtattaagta ttaattccat gcggatatag gcggaagtta atacttaata
     6001 ctttttttat gccgttattc cagctattac ttattacttg ttacttatta cttgttactt
     6061 attacctgtt aacatcctcc tttgtgcgtc atgatatcaa gcaccatctt atccgtttcg
     6121 ttcatggcct gcgagccgat tcttgtcaag ttacgaatgc tttgatcgac atcttcgtca
     6181 ataatgcctt ctacagaagt cacacaacgg tcctccattg ccatcatagc agataatacg
     6241 gctgttgaga ctccggttgt tactttgagt gcgcagctcg gttttgcacc gtcgcaaatc
     6301 attcccgtca ggttggcaat catgttttga acggcaaagg ctacctgatt atagtttcca
     6361 cccatcagcc aggtgattcc gcaactggaa cccgtggcag ctactacaca gccacacaag
     6421 gcagagagac gtcccaaact ttgtttaata tagattacag tgagatgact cagcattaag
     6481 gcgcggatca gttcctcttc ggttttacca ttttcttcgg caaatacgac aacgggaagt
     6541 gtggcggata tgccctgatt gccactgccg gagttactca tgacgggaat cattgcacca
     6601 gccattctgg cgtcgcaagc ggcggaagta taagatagta tatgagagaa tacgctgtca
     6661 cccatcactt tatgttcata cgttccacgg agcatcttac ctaaagaatg cccataattg
     6721 cctttaaagg cttgctcggc ggctgctttg ttcagacgtg ccgtatcgag aataaaacgg
     6781 atttcatcca gaggggatgt cagggcaaaa tcatagactt tgcgcagatt cagttccagt
     6841 gaagcgtctt cttcctcttc attggcagtc tgttgcttgt caagcagtac tttttcatcc
     6901 gtagctatat agacaaaggt agtatgtccg ccggcaatca cagccgtcgc tttttggctg
     6961 ccggctgtgc agattacttc gatgtacagt ttttccgtaa tatcttcttt gagagaaata
     7021 cagattcgct tctctgcgat aaacagtttg ccttgttcta ctgcctccgg tgtgcagtct
     7081 ctcaacactt ccaattgata ttccgatcgg ccgatcaacg ctcccaaggc tacagctata
     7141 ggaagtccga ccatatctgt gccggggata ccgactccca ttgcattctt taatatattg
     7201 gcactcaata acacttcaat cttttccggt ttcattccta atgtttcggc agctttagct
     7261 acacaaagcg ctaccgcaat gggttccgta caccctatcg ccggaatcac ctcttttttg
     7321 atcaagtcta ttatctgttt tctttccgat tcaatcatac cctataaggc tttagtttcc
     7381 acaaaagtag aaaattcttt tttatcaaac atccattagt gaacaaataa aattgcagat
     7441 tgttataaaa tcttccaaga accgaacttt aacagttaga atagtagaaa aatgaaagca
     7501 aaacacggta ttctttattt gctgctagcc attttctctt cttcttgcat tcgcgaagaa
     7561 gctcccaatg cagaggcaga catactcagt tgcagattgc cgggagtagt catgacaacg
     7621 agtccgatta tcactaataa ttccatcaat atatttgtag gaccgggaac ggacatttca
     7681 tcccttgcac ccgaatttac attgactccg ggagccacta tcgatcctcc cagtgggacg
     7741 gctagagatt tccattcgcc tcagcaatat accgttacgg ctgccgatgg cttttggaag
     7801 aagaagtaca ccgtatccgt tattgatacg gaacttgcta ctatttacaa ttttgaggat
     7861 acgctcggtg gacagaaata ctacatcttc gtagaacggg aaggagaaaa agtggtgatg
     7921 gaatgggcca gcggaaacgc aggttatgca atgaccggag ttcccaagac agccgacgac
     7981 tatccgactt ttcagtttgc aaacggaaaa accggaaaat gcctgtcctt agtaacccgc
     8041 agtaccggat tcttcggtag cattatggga atgcctatcg cagccgggaa cctgtttatc
     8101 ggctcttttg atgtaggaaa tgcaatgagc aatccactga aagcgaccaa attcggtctg
     8161 cctttccggc atataccaac ttatctggca ggctattaca agtataaagc cggagatcag
     8221 tttacagaag gcggcaaacc cgtcagtggc aaacgggata tatgcgatat ttatgccatc
     8281 atgtatgaaa ccagtgaatc tgtgccgact cttgacggaa cgaatgcttt caccagtccc
     8341 aacctggttt caatagcacg cattgacgac gccaaagaga cggacgagtg gacatacttt
     8401 aaacttccct ttcatatgtt atccggaaaa tacatagata aagagaagct aacagcagga
     8461 aagtataatg tagctatcgt attcacttcc agcctggaag gagatcattt taacggagct
     8521 atcggaagta cattgttgat tgatgaagtc gaactaatct atcgctcgga agactgattc
     8581 cattcgacca acgatctgat agcagctatg gaaggcagaa cagagcaact ataatgaaat
     8641 aactaatgat ttaataataa tgaaaagatg aaaatccatt cctatatatt cagtttactc
     8701 gcctgtctgg tgatagccct ccccggctat tcacaggttg acagaaacga aacacttatt
     8761 cgctccgctc ttcacggact ggaatatgaa atcaaagcag ggttcagcat cggcggtaca
     8821 gccccgctcc cgctgcctgt cgaaatccgt tcgattgacg gctacaaccc aacgctggct
     8881 atcagcatcg gaggagaagt aaccaaatgg tttgccgttc aaaacaagct cggagtcatt
     8941 gtagggctgc ggctggagaa taaagccatg acaacggaag ccaccgtcaa aaactataat
     9001 atggaaatcc tcggacaggg aggagaaaga atcagcggtg tctggacagg aggagtcaaa
     9061 accaaagtcc acacttccgg actgacaatt cctctaatgg ctacttacaa gttgagcaac
     9121 cgttggaata ttaaagccgg accttatttt tcatatctgc tttcaagaga attttcgggg
     9181 cacgtatatg aaggatacct gcgcgaaggc gaccccgtag gtcccaaagt agaatttacg
     9241 gatggtaaaa tcgctactta tgacttctcg gacgacctga gacattttca gtggggcctg
     9301 caaataggag ccggatggag agcattcaaa catctcaata tatatgcaga cctcacttgg
     9361 ggattgaatg atatcttcag aaatgacttt cagaccatta cttttgctat gtatccgatc
     9421 tacttgaata tcggattcgg atatgctttc tagctaagca aagacggatt aatccttacc
     9481 ggattcctcc acctgcttca cgccggagaa agcaactttc acagtctgct gcaatgcagg
     9541 cacttttacc tgaatattca tcgtagcatt tccgccttgt accgttcctt ctatactggt
     9601 ggcacaggta cccagagcgg cagcatctcc ttgaaaagta aggtcttgct gtccggtgaa
     9661 agtcgaagca tccgtttcct ttttcaccgc acacttgtct atcacgatat cgccgaactt
     9721 taatatgttt ccgtttataa acagttcaaa ttccttcagt tccatcttta cttccgtatc
     9781 gctgacctga gagaaagtaa taaacttcgg aagtccgtcg gcaatcacaa cttcctggtc
     9841 ggagccatcg ggcagcattg aaatatcgag atttccccaa tacgttccca ccacgtcggg
     9901 agcagtcacc acagcttctt cttccggagg agtcgtttca tcattgaccg tattatcgtc
     9961 atcactgcta caagccgtca aaagagagac agagcatatc aatgcccaca aatacaatag
    10021 attctttttc ataattttcg ggtttagtta ttaaataatc gtcatttata aactaaaaag
    10081 aggaaaaaag gttcaatttg cttccttttc cgaagatatt ttgaattcac aaccttctta
    10141 tcgaaaactt tgttatattt gcatagagta attttaaaaa agccacaact atgtttaatt
    10201 catttggcaa catctttcga ctcaccagtt tcggcgagtc tcatggaaaa ggagttgggg
    10261 gagtaattga cggatttcct tccggaatca caatcgacga agaatttgta caacaagaac
    10321 taaatcgacg ccgtccggga caatccatcc tcaccacacc acgcaaggaa gcggataaag
    10381 tggagtttct ttcaggcatc ttcgaaggca aatcaaccgg atgtcctatc ggatttatcg
    10441 tttggaacga gaatcaacat tccaatgact acaataacct gaaagaggta taccgccctt
    10501 cacacgcgga ttacacctac aaagtgaagt acggcatccg tgatcatcgc ggcggcggac
    10561 gttcttctgc ccgcgagact atttcacgcg tagtagccgg cgcattggct aaattagccc
    10621 ttcgccagtt aggaatcagc atcacagctt atacatcgca agtcggtgcc atcaaattgg
    10681 aaggcactta ttccgactat gatctcgacc tgatcgaaac aaacgacgta cgctgtccgg
    10741 acccggaaaa ggcgaaggaa atggcagacc ttatatataa ggtaaaaggc gaaggcgata
    10801 ccatcggagg tacgctgacc tgtgtcatca aaggatgtcc tatcggattg gggcaacccg
    10861 tattcggcaa gctgcacgct gccttgggca acgccatgct cagtatcaat gccgccaaag
    10921 ccttcgaata tggagaagga ttcaagggac tgaagatgaa aggctccgag cagaacgacg
    10981 tattcttcaa caacaacgga cggattgaaa cgcataccaa ccactccgga ggtattcagg
    11041 gaggaatcag taacggacag gatatttact tccgtgtagt attcaaaccg attgctaccc
    11101 tgctgatgga gcaggaaacg gtgaacatcg acggcgtaga tacgacattg aaagcccgcg
    11161 gacgtcatga cgcctgtgta ctgccacgtg ccgtacctat cgtagaagca atggctgcca
    11221 tgaccatcct tgattattat ctgttggata agacaacgca gctttaataa gtatcaatat
    11281 gtcaatctac ccatgtgcca atacctgcac taaaaatctg tcaggctatt ggcacatagg
    11341 ctaaataacc gccagtaaac tattcattat gaacgaaatt caaaaatata tcgcagcgaa
    11401 cgaaccgaag attatggagg acctgttcag cctcatccgt attcccagta tcagcgccct
    11461 gccggaacat cacgacgata tgctggcttg cgcccaacgc tgggcacaac tactgctcga
    11521 agccggagtg gatgaagcat tggtgatgcc ttccaagggt aacccgattg ttttcgcaca
    11581 aaagatcgtt gacccgaatg ccaaaacagt attggtctac gcccactacg acgtaatgcc
    11641 tgccgaaccg ctggaactgt ggaaaagcca gcccttcgaa cccgaagtac gggacggata
    11701 catctgggca cgcggagcgg atgatgacaa aggacaatcc tttatccagg tcaaagcctt
    11761 cgaatatctc gtcaagaacg aactgctgaa aaataacgtc aagtttatct tcgaaggaga
    11821 agaggaaatc ggctctccca gcctggaagc cttctgcgaa gagcataaag agctgttgaa
    11881 agcagacgtt atcctggttt cggataccag catgctgggt gccgaacttc catccctcac
    11941 caccggtctg cgcggactgg cttactggga aatagaagtg accggaccga accgtgacct
    12001 gcattcggga cacttcggag gtgcggtagc taatccgatc aatgtgcttt gcgaaataat
    12061 cagcaaagta acagataaag acggaagaat caccgccccc ggattctacg atgacgtaga
    12121 agaagtaccg caagcagaac gggaaatgat cgcccatatt ccgttcgatg agaagaaata
    12181 caaagaagcc atcggagtga aagaactctt cggagaaaag ggatacagca cactggaacg
    12241 caacagttgc cgcccgtctt tcgatgtatg cggcatttgg ggaggatata caggtgaagg
    12301 ctccaagaca gtccttccct cgaaagcgta tgcgaaagtt tcctgccgac tggttgcgca
    12361 tcaggatcat cacaagattt cgcagatgtt tgcagattat atcttacaaa tggctcccga
    12421 caccgtacag gtaaaagtaa ccccaatgca cggaggacag ggatatgtct gcccgatttc
    12481 ccttcctgcc tatcaggctg cggaaaaagg ttttgagata gctttcggca aaaaaccgct
    12541 ggcagtacgt cgtggcggaa gtattcctat catttcgaca ttcgaacagg tattaggaac
    12601 caaaaccgta ttgatgggct tcggacttga atcggatgcg atccattcac ccaacgaaaa
    12661 cttctcgctg gacatattcc ggaaaggaat agaggcagtg attgagttcc atcaggaata
    12721 tgcgaaaaga taaaggctgc ctatagccgc acgcaggaca cgaagataaa agaagaacgg
    12781 tagacaagcg gataaatcct ttgcctaccg ttccttttta ttcaaaaaaa gacctcttac
    12841 cacataacta actatcgact acatcaccgg agtttcgaaa aggaaagtaa atgattgact
    12901 atccttcaaa tccttcacgg catctcctgc gtaaatttct cctttggtca aggacagttt
    12961 cttcacccca gccttcggac taaaatcaat cttcttcaaa tccagccaaa acaggttcgg
    13021 agttaaagta gactcaaagt aatacacttt attcttctga tcggaaacgg aacgccagcg
    13081 agtagaagaa atgtgaggct tctccggtgt attgatacca aacggaacgg agacattgcg
    13141 catcacactc agcacactgg ggacagctat ctttgcatcg gcagtctgcg gaatggcgtg
    13201 aatgtagaaa gaggcacgca caaaacggtc gctcgaacgg ttcgttcccg gcaacatctg
    13261 caatccaccc acttctttcc agtaatcatt gacagccaac tgcaattcat aacgcggaga
    13321 attggtcatc acctgatatt ctttcccctc atggatactc agtttgccat ccagatattc
    13381 aatcactgcc gtgttgcctg tttcatcggt aatagccatg tgcaaagtag attccggtcc
    13441 cccgttcggc atacggggag cgtcaatacg gaaagtctct tttttcattt catctaccgc
    13501 ctcacgcacc gttgcaaaat tgtcaagcac atattgagtc cagatactga ttcccattgc
    13561 cggacgggta tctccgggaa gtgaataaac agattccggc aagaagagca agcttgccac
    13621 cagtcctttt tcattcattc cgtcacaagt acctatatca tagcctgttg caattacgct
    13681 tccatatttg gaagtccagt ttactgtttt ttctttattg tgtcccgcac gctgcattcc
    13741 acgtggaaac acatagatat ttgacataat gtcttctttc cagtccatcg tgcgaccagt
    13801 gaccaccatt ccgtccggtc ccagatatac ggcacgcgta catgcttccg ccggctgtat
    13861 gcccatcaaa gagacggcag ctaacaccaa tgcaacaccc gtaagttttt tcttcatatt
    13921 ccttccaaat taaatagttg atactcttat atctataata acaaatatac aacgaatatt
    13981 gcctgagaga gagaagaatt taagggaaaa aagggaattt attcagaaaa aatcttatct
    14041 gctcttattt gagttaaaaa agcctgcgga tggaaggaaa cattacacat tatttgcttt
    14101 tcaaatggga tttcattatt tttgtacata acctatcata aaaactaagg agggcaaatg
    14161 cgtatgagac aaaaagttag catatcacgg cttccaattc gtttgggaat ctttcttttg
    14221 ctgtattttg ttccgcagtt actctccgcg caagaaaaca acgacagcac gcacatactt
    14281 cgtaacggtg catccataac gccggacgac gtacttaaac aggccaacat taacttgttt
    14341 ccagaaaaga gcactacata ttctttatat tcacccggac agttggagca tataccccgc
    14401 ttttcactca aaagggatat ttccctacct tatcagacca atccttccct actcttccga
    14461 ggtgattaca gcacgggcgg ggtattgcat caattcgatc atggagcact gttcggttcc
    14521 ggaagccaga caagtatggc aggcatcggt cgtttcaaca gtgcttcact aggttatcag
    14581 cacattttca atgagcaatt cgagttacaa gtccgtgcca atgcgctgaa agtcaacatg
    14641 tcccatatca ccggacaggc tttcagcact tcgggcgcct tcctttatca tccttccgac
    14701 catgtcacct tcaaggtctt cggttcatac gatatcggaa attcttacgg gatgagtacc
    14761 catagctacg gagctacgat gtccgtcgat atgtccgacc gctttgggat ggaaatggga
    14821 gtacagcgat actatgacgc gatgagcgga cgttgggaaa cggttcccgt tatgattcct
    14881 tactaccatt tcgataagtt cacactgggt ttggatgtgg gtggtattat atatgagatt
    14941 ctccgcaatg ccgtttttga taaaaacaga ggtataggtg gtccatccgg cccgacaatc
    15001 ggaccacccc ggatgcatat acctatacgg taaaatcccg t
//
