LOCUS       gnlProkkaNAEKIINI_85    9196 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NAEKIINI_85.
ACCESSION   gnlProkkaNAEKIINI_85
VERSION     gnlProkkaNAEKIINI_85
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 18:11:01
            Original ID  :: gnl|Prokka|NAEKIINI_85
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 9196
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..9196
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[1012:8521]"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1013..8521
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
     cand_cluster    1..9196
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(APE_KS1 or APE_KS2)"
                     /kind="single"
                     /product="arylpolyene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..9196
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="arylpolyene"
                     /region_number="1"
                     /rules="(APE_KS1 or APE_KS2)"
                     /tool="antismash"
     CDS             complement(56..1009)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg85_1"
                     /sec_met_domain="ketoacyl-synt (E-value: 8.9e-08, bitscore:
                     21.5, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPVYINRIASIHAESSNEKPYFSAQEPDYKEMITNANLRRRMSR
                     MIKMGVACGLECLKDISPEKVDAIITATGLGCLADTEKFMNALMDNREQMLNPTAFIQS
                     TFNTIGAQIALLLKIHAYNVTYVHRGLSFESALTDGIMSIAEGKQHVLAGAMDEITPTS
                     YIIQQRLGLLKGTTAGEGAQFFLLSAQKEEQTFAELKGVDTFITRMSAPEISNRMHHFL
                     KSHELAPEDIDWFISGKNGQEATDAVYTELEHSLFPHALHSSFKEQCGEYQTASSYALW
                     MAAKALKEEASSRYALIYNQYQGINHSIILIKRCTS"
     CDS             complement(1013..2203)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (128-392). E-value:
                     1.2e-36. Score: 118.4. Matches aSDomain:
                     nrpspksdomains_ctg85_2_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 261.7; E-value:
                     2.1e-79)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg85_2"
                     /sec_met_domain="APE_KS2 (E-value: 2.4e-142, bitscore:
                     464.0, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRKIYVTGLGVISGIGQGVKENLDSLKSGKHGMGKITLFPTVLDV
                     PVSEVKQSNEELKQILFLPSGKTYSRTALLGLLAAQEAARDAELDFASPRIGLISSTSI
                     GGMDASERFYASFREDNRKGRLRDIISHDCGASTEMIAAYLGVKGMVTTLSTACSSAAN
                     AIMLGARLIRHGYLDTVLVGGTDALCRFTLNGFNSLMILDKEHCRPFDRTRAGLNLGEG
                     AGYLVLQSEKSLTKAPYCELSGYANANEAYHQTGSSPDGNGPFLSMSQAIASAGLTAGA
                     IDYINVHGTGTPSNDASEGKAIRRIFDTRIPPFSSVKAFIGHTLGASEGIEAVYSVLSI
                     RHGLIYPNLNFHLSDEESGLIPETIFRSGLPIRHVLSNSFGFGGNNSSLVFSTLNR"
     aSDomain        complement(1028..1819)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg85_2_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="1.20E-36"
                     /label="ctg85_2_PKS_KS.1"
                     /locus_tag="ctg85_2"
                     /protein_end="392"
                     /protein_start="128"
                     /score="118.4"
                     /tool="antismash"
                     /translation="IISHDCGASTEMIAAYLGVKGMVTTLSTACSSAANAIMLGARLIR
                     HGYLDTVLVGGTDALCRFTLNGFNSLMILDKEHCRPFDRTRAGLNLGEGAGYLVLQSEK
                     SLTKAPYCELSGYANANEAYHQTGSSPDGNGPFLSMSQAIASAGLTAGAIDYINVHGTG
                     TPSNDASEGKAIRRIFDTRIPPFSSVKAFIGHTLGASEGIEAVYSVLSIRHGLIYPNLN
                     FHLSDEESGLIPETIFRSGLPIRHVLSNSFGFGGNNSSLVFS"
     CDS             complement(2200..2457)
                     /NRPS_PKS="Domain: PP-binding (16-79). E-value: 1e-10.
                     Score: 33.9. Matches aSDomain:
                     nrpspksdomains_ctg85_3_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg85_3"
                     /sec_met_domain="PP-binding (E-value: 2e-11, bitscore:
                     33.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEELIEKLKVELIEALNLEEITPEDIDSEAPLFGDDGLGLDSIDA
                     LEIILILERNYGIKIENPAKGKEIFYSVRTLADYITAHQK"
     aSDomain        complement(2221..2409)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg85_3_PP-binding.1"
                     /evalue="1.00E-10"
                     /label="ctg85_3_PP-binding.1"
                     /locus_tag="ctg85_3"
                     /protein_end="79"
                     /protein_start="16"
                     /score="33.9"
                     /tool="antismash"
                     /translation="NLEEITPEDIDSEAPLFGDDGLGLDSIDALEIILILERNYGIKIE
                     NPAKGKEIFYSVRTLADY"
     CDS             complement(2463..4193)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (97-378). E-value:
                     2.3e-24. Score: 77.9. Matches aSDomain:
                     nrpspksdomains_ctg85_4_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 161.3; E-value:
                     6.1e-49)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg85_4"
                     /sec_met_domain="APE_KS2 (E-value: 1e-125, bitscore: 409.3,
                     seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHHLTTYITHDTLISALGFGTQENLEAIRSYHSGITLQTDKRIA
                     DTPLLAATISQERLQQQAEAIGVSGYPRMEQLFILTINELIRQSGQTLEDKTCGLILST
                     TKGNIDLLTRHTEHPDEAVFLWKMAENIAGYFHAEERVHVISNACISGVSALVTGKRMI
                     ENGIYRKVIVAGGDLLSHFITSGFLSFRSLSSRPCRPYDSNRDGLNLGEACGAVLLSTE
                     KTPNSIILSGGAISNDANHISGPSRTGDGLFFAIRQAMQEAGTALQNISFVNAHGTATV
                     YNDEMESRALTLAHLEQVPTHSLKPYFGHTLGASGIIESIVCMHELKQGILFGTPGYET
                     PGVPMPIPVYATHQHIPMKHCVKTASGFGGCNAAIVLSLPEYAPFKDEDNTLPEIRCTR
                     EVRIENSSVFINNELIFHSEEPDFGTFIRDTYKKTGGNNLKFYKMDDLCKLGYVAAEYL
                     LEGKTFAPLEMGMLLANAASSLHTDIRHQQLIDREGDQAASPAVFVYTLPNVVSGEICI
                     RHKIQGENTFFITEAYQPEKLERYARIVMQKGKLNYCIIGWCELLKNTYKAVFKLIEKQ
                     "
     aSDomain        complement(3060..3902)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg85_4_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="2.30E-24"
                     /label="ctg85_4_PKS_KS.1"
                     /locus_tag="ctg85_4"
                     /protein_end="378"
                     /protein_start="97"
                     /score="77.9"
                     /tool="antismash"
                     /translation="CGLILSTTKGNIDLLTRHTEHPDEAVFLWKMAENIAGYFHAEERV
                     HVISNACISGVSALVTGKRMIENGIYRKVIVAGGDLLSHFITSGFLSFRSLSSRPCRPY
                     DSNRDGLNLGEACGAVLLSTEKTPNSIILSGGAISNDANHISGPSRTGDGLFFAIRQAM
                     QEAGTALQNISFVNAHGTATVYNDEMESRALTLAHLEQVPTHSLKPYFGHTLGASGIIE
                     SIVCMHELKQGILFGTPGYETPGVPMPIPVYATHQHIPMKHCVKTASGFGGCNAAIVLS
                     "
     CDS             complement(4178..4621)
                     /locus_tag="ctg85_5"
                     /transl_table=11
                     /translation="MKRKTSPQQAALTDRTTIKVRFSEIDSMQIVWHGEYVRYFEDGRE
                     AFGKRYGLDYMSIYREGYLVPIVDLSCQFKQPLSFGEEAIVETRYIHSDAAKILFEYTI
                     YRASDQNIVATGTTTQVFLNTNRELELVNPAFYIEWKKKWNII"
     CDS             complement(4618..5055)
                     /locus_tag="ctg85_6"
                     /transl_table=11
                     /translation="MNRKEIICRGDELFRLIPQRPPMVMIDRFYGIEENTSWSGLTVTP
                     DNLFCRDGVLQETGIIEHIAQSAAARVGYIYMLREEPVPLGFIGSVEKMKIFRLPSAGA
                     ELYTGITIVQEIFDITLITAEVKENDELLAECRMKIYLKKE"
     CDS             complement(5052..6122)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 113.1; E-value:
                     2.8e-34)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg85_7"
                     /transl_table=11
                     /translation="MMHKRYTKEQLTAVEAQRLAQEIAFGPVVFQVSRLMLKFGIFQLL
                     ADKRKGYTLQEISVQTGLTRYAAQVLLEASLTIGTILLEEDRYVLAKAGWFLLNDKMAR
                     VNMEFNHDVNYQGLFYLEEALLNGQPEGLKVFGGWPTIYEGLSQLPEQVQKSWFGFDHF
                     YSDNSFSQALEIVFLHSPKRLLDIGGNTGRWATRCVQYNQEVEVTIVDLPQQLEMMRKQ
                     TADVPGAERIHGHGANLLDRTVPFPSGFDTVWMSQFLDCFSEEEATSILSRVAQSASKD
                     SKVYIMETLWDRQPYETGSYCLTQISLYFTAMANGNSKMFHSDDLIRCIKNAGLEVEEI
                     HDNIGLGHSILQCRLK"
     CDS             complement(6138..7022)
                     /locus_tag="ctg85_8"
                     /transl_table=11
                     /translation="MPETWKGKTRGGTFGYMFFIYMIRCLGITAAYGFLSLVVLYFIPF
                     APKATASTWQYARNRLKYGRAKAAGLLLKNYYRLGQILIDKVAIGNGMADKYHFEFENY
                     QAFLNVLNGNTGVIMIGAHVGNWEIGAPFFDEYGKKINIVMFDAEHERIKEILEKNAST
                     RDYKIIPVNEDNLTHVFRITEALERKEYVCFQGDRYLNKEKLLSSPFMGKEAEFPMGPF
                     LLASKMRVPVVFYFAMREAKKNYRFHFFIAEAVVHTKEKRAEQALLEQYTQTLEKIVRQ
                     YPEQWFNYYPFWA"
     CDS             complement(7022..7273)
                     /NRPS_PKS="Domain: PP-binding (7-74). E-value: 5.9e-13.
                     Score: 41.1. Matches aSDomain:
                     nrpspksdomains_ctg85_9_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg85_9"
                     /sec_met_domain="PP-binding (E-value: 1.2e-13, bitscore:
                     41.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNEEIIEKIRTTLAEEFEIDVELIQPDAPLMQTLELDSLDLVDM
                     VVLIDRNFGFTVTAKDFAGIKTFQDFYNLVISHIQKED"
     aSDomain        complement(7052..7252)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg85_9_PP-binding.1"
                     /evalue="5.90E-13"
                     /label="ctg85_9_PP-binding.1"
                     /locus_tag="ctg85_9"
                     /protein_end="74"
                     /protein_start="7"
                     /score="41.1"
                     /tool="antismash"
                     /translation="EKIRTTLAEEFEIDVELIQPDAPLMQTLELDSLDLVDMVVLIDRN
                     FGFTVTAKDFAGIKTFQDFYNL"
     CDS             complement(7295..8521)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (77-404). E-value:
                     4.2e-50. Score: 162.7. Matches aSDomain:
                     nrpspksdomains_ctg85_10_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 309.3; E-value:
                     7.1e-94)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg85_10"
                     /sec_met_domain="APE_KS1 (E-value: 8.5e-171, bitscore:
                     557.6, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRVVITGMGIYSCIGKNQDEVKDSLFQGRSGIGIDPARKEMGYF
                     SALTGLVERPDLKKLLDRKKRHSLAEQGEYAYMATLEAFRQAQIDEEFLLDHEVGILYG
                     NDSSAAPVIEAIDVIRAKKNTAMVGSGSIFQSMNSTITMNLSVIFHLKGINFTISGACA
                     SGSHAIGMAYMLIKSGLQDCILCGGAQEVNPYSVGSFDGLGAFSTREDEPEKASRPFDK
                     GRDGLVPSGGGASLVLESYESAVRRGATILAEVIGYGFSSNGDHISVPNVDGPRRSLQM
                     AINDAGIPLEEIQYINAHATSTPVGDLNEAKAIAEVFGNRPYVTSTKSQTGHEMWMAGA
                     SEVIYSILMMNNGFIAPNLNFEEPDEASALLNIPSRRIETEFDTFLSNSFGFGGTNSSL
                     IIRKFKENN"
     aSDomain        complement(7310..8290)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg85_10_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="4.20E-50"
                     /label="ctg85_10_PKS_KS.1"
                     /locus_tag="ctg85_10"
                     /protein_end="404"
                     /protein_start="77"
                     /score="162.7"
                     /tool="antismash"
                     /translation="MATLEAFRQAQIDEEFLLDHEVGILYGNDSSAAPVIEAIDVIRAK
                     KNTAMVGSGSIFQSMNSTITMNLSVIFHLKGINFTISGACASGSHAIGMAYMLIKSGLQ
                     DCILCGGAQEVNPYSVGSFDGLGAFSTREDEPEKASRPFDKGRDGLVPSGGGASLVLES
                     YESAVRRGATILAEVIGYGFSSNGDHISVPNVDGPRRSLQMAINDAGIPLEEIQYINAH
                     ATSTPVGDLNEAKAIAEVFGNRPYVTSTKSQTGHEMWMAGASEVIYSILMMNNGFIAPN
                     LNFEEPDEASALLNIPSRRIETEFDTFLSNSFGFGGTNSSLIIRKF"
     CDS             complement(8529..9194)
                     /NRPS_PKS="Domain: PKS_KR (14-150). E-value: 2.4e-13.
                     Score: 42.2. Matches aSDomain:
                     nrpspksdomains_ctg85_11_PKS_KR.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     182.8; E-value: 1.3e-55)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg85_11"
                     /transl_table=11
                     /translation="MEMGYHILINYQSNDTEAEATLQQIREQGSDGELMKFDVTDAVAT
                     HAALNGWMEKHPDTYIEVLVNNAGIRRDNLMLWMEQDEWSRVLDISLNGFFNVTQPLLK
                     NMLVKRFGRIINIVSLSGIKGMPGQTNYSAAKGGMIAATKALAQEVARKHVTVNAVAPG
                     FIRTDMTNGIDENEWKKQIPAGRFGEPGEVAALVGFLASEQASYITGEVISINGGIYT"
     aSDomain        complement(8745..9152)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg85_11_PKS_KR.1"
                     /evalue="2.40E-13"
                     /label="ctg85_11_PKS_KR.1"
                     /locus_tag="ctg85_11"
                     /protein_end="150"
                     /protein_start="14"
                     /score="42.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="DTEAEATLQQIREQGSDGELMKFDVTDAVATHAALNGWMEKHPDT
                     YIEVLVNNAGIRRDNLMLWMEQDEWSRVLDISLNGFFNVTQPLLKNMLVKRFGRIINIV
                     SLSGIKGMPGQTNYSAAKGGMIAATKALAQEV"
     CDS_motif       complement(8790..8840)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg85_11_0001"
                     /evalue="3.20E-05"
                     /label="PKSI-KR_m4"
                     /locus_tag="ctg85_11"
                     /protein_end="135"
                     /protein_start="118"
                     /score="16.4"
                     /tool="antismash"
                     /translation="SLSGIKGMPGQTNYSAA"
ORIGIN
        1 atcttaaaag catcttttta ataggccatg acgcttacta tgatgactac agaaactagg
       61 atgtgcatcg cttgattaag atgattgagt gattgatacc ttgatattgg ttataaatca
      121 atgcgtaacg ggatgaagct tcttctttca aggcttttgc cgccatccag agagcatagg
      181 atgaggcagt ctgatattct ccgcattgct ctttaaagct gctatgcagg gcatgaggaa
      241 acagactgtg ttccagctct gtataaacgg catctgttgc ttcctgcccg ttcttgccac
      301 tgataaacca gtcaatgtct tcgggtgcaa gctcgtgaga ttttagaaaa tgatgcatcc
      361 tgttactgat ttccggagca ctcatccggg tgataaaagt gtccacccct ttcagttcag
      421 caaaagtctg ttcctctttt tgtgcgctta acaggaaaaa ttgtgctccc tcaccggctg
      481 tcgttccttt caacagtcct aaacgctgct ggatgatgta gctggtaggg gttatttcat
      541 ccatagcacc tgccagtaca tgctgtttgc cttcggcaat actcatgatg ccatctgtca
      601 gagcactttc aaaacttaaa ccacggtgta catacgtcac attataagca tgtattttga
      661 gtagcaaagc tatctgtgca ccgatcgtat taaaggtgga ctgaatgaaa gcggtgggat
      721 tgagcatctg ttcccggtta tccatcaagg cgttcataaa cttttccgta tcagccagac
      781 aacccagtcc cgtagcggtg ataatggcat ctaccttttc cggcgatata tctttcagac
      841 attccagtcc gcaagctact cccatcttga tcatgcggct catgcgcctc cgcagattgg
      901 cgttggtgat catttcttta taatcaggtt cctgtgcgga gaaataaggc ttttcattgc
      961 tgctctctgc atgaatagag gcgatacgat tgatatatac tgggcgcata cgctatctgt
     1021 ttagagtgga aaatacgaga gatgagttgt ttccgccgaa tccgaaggag ttggataata
     1081 catgccgtat gggaagtccc gaccggaaaa tcgtttcagg aatgagaccg ctttcttcat
     1141 cggacagatg gaagttcaga ttagggtaaa tcagtccgtg acggatggag agtacggaat
     1201 atacggcttc tattccttcc gaggctccca gggtgtgacc gatgaaagcc ttgaccgaac
     1261 tgaaaggtgg aatacgggta tcgaagatac gccggatggc tttcccttcg gaagcgtcgt
     1321 tactgggagt acctgtgcca tgtacattga tatagtctat ggctccggct gtcagtccgg
     1381 cagaggctat ggcctgactc atggaaagga aaggcccgtt tccatcgggg gaacttcctg
     1441 tctgatggta ggcttcgttg gcattggcgt aaccgctgag ttcacaataa ggagcctttg
     1501 taagggattt ctccgattga agaacaaggt atccggctcc ttctccgagg tttaatccgg
     1561 cacgtgtgcg gtcgaaagga cggcagtgct ctttgtccag tatcatcaat gaattgaaac
     1621 cgttgagcgt gaaacggcat aaggcatccg ttccacctac gaggacggtg tccagataac
     1681 cgtgtcgaat caggcgtgcc cctaacataa tggcatttgc agccgaagaa caggcggtgc
     1741 tgagggtggt caccattcct ttcactccta aataagcggc tatcatttcg gtactggctc
     1801 cacagtcatg ggagataata tcacgtaatc ttccttttcg gttatcctcc cggaaagagg
     1861 cataaaaccg ctcgcttgca tccattcctc cgatggaagt ggaagaaatg agtccgatac
     1921 ggggagaagc gaaatcgagt tccgcatcac gggctgcctc ttgagctgcc aacaagccta
     1981 gcagggctgt acgtgaatac gttttgccgg atggaaggaa caggatttgc tttaattctt
     2041 cattgctttg tttcacttcg gacacgggta cgtcaagcac ggtggggaaa agggtgattt
     2101 tccccatacc gtgttttccg gattttaagg agtccagatt ttcttttact ccttgtccta
     2161 tgcccgaaat cactcccaga ccggtgacat agatcttcct catttctgat gggcggtgat
     2221 gtagtctgcc agggtacgca ccgaatagaa tatttccttt cctttggcag gattctctat
     2281 tttaatgcca taattccttt ccagaatcag gataatctct aatgcgtcaa tcgagtcaag
     2341 acccaatccg tcgtctccga ataaaggtgc ttcactatca atgtcctccg gagtgatttc
     2401 ttccagattc aatgcttcta ttaattcaac tttcaatttc tcaatcaatt cttccatatt
     2461 ctttattgtt tttcaatcag tttaaatact gctttatagg tgtttttcaa taattcacac
     2521 catccgatga tacaatagtt cagtttccct ttttgcatga ctatacgtgc gtatctttcc
     2581 agtttctccg gctgataggc ttcagttatg aaaaaggtgt tttccccttg tatcttgtgg
     2641 cggatgcaaa tctcgccgga cactacattg ggtagtgtgt aaacaaatac agccggactg
     2701 gctgcctggt ctccttcccg gtctatcagt tgctggtgtc tgatgtccgt atgcagagag
     2761 gaagcggcat tggcaagtaa catccccatt tccagtggag cgaatgtctt accttccagc
     2821 aagtattcgg cggccacata tcccaatttg caaaggtcat ccattttata gaatttcagg
     2881 ttgtttccgc ctgttttttt ataggtatca cgtataaatg tgccgaaatc cggttcttcg
     2941 gaatgaaaaa taagttcgtt gtttatgaag acagaactgt tttcaatacg aacctcccgt
     3001 gtacatcgga tttcgggcaa ggtgttgtcc tcatccttga acggagcata ttccggtaaa
     3061 gacaagacaa tggctgcgtt acacccaccg aatcccgaag cggtttttac acaatgtttc
     3121 atcggaatgt gttggtgagt tgcatagacc ggtataggca taggcacacc cggtgtttcg
     3181 taacccggag tgccgaacag gatgccttgt ttcagttcgt gcatacagac aatgctttca
     3241 atgattcccg atgctcccaa ggtatgcccg aaatagggtt ttaagctatg tgtgggaact
     3301 tgttccagat gagccagcgt gagggctctg gattccattt catcattgta tacggtggcc
     3361 gtgccatggg cattgacaaa gctgatgttt tggagggctg ttcctgcctc ctgcatggct
     3421 tggcggatag cgaaaaagag tccgtctcct gtacgggaag ggccggagat atggttggcg
     3481 tcattactta tggctcctcc ggagagaatg atgctatttg gcgtcttttc cgtacttagt
     3541 aatacggctc cgcaagcctc tcccaagttc agtccgtcac ggttgctgtc atacggacgg
     3601 catggacggg agctgaggga ccggaaagac aggaaaccac tggtgatgaa atgagagaga
     3661 aggtcacctc ccgctacaat taccttgcgg tagatgccgt tctctatcat gcgttttcct
     3721 gttacaaggg ctgacactcc tgatatgcag gcgttggaga tgacatgtac ccgttcctcg
     3781 gcatggaaat aaccggcaat gttttctgcc attttccaaa gaaagaccgc ttcatcggga
     3841 tgttccgtat gacgggtcag taagtcgatg ttcccttttg tggtagagag gatgagtccg
     3901 caggttttat cttccaaagt ttgtccggac tgacggatga gttcgttgat agtcagtatg
     3961 aacagttgtt ccatccgggg atagccactt actcctatgg cttctgcctg ttgttgcaat
     4021 ctctcttgcg agatagtagc tgccaatagg ggagtgtctg caatccgttt gtccgtctgc
     4081 agggtgatac cgctgtgata gctccggatg gcttccagat tttcctgtgt gccgaaaccc
     4141 agcgcgctga tcagggtatc atgggtgata taggtagtca gatgatgttc catttctttt
     4201 tccactctat gtaaaaggca ggattaacca attccagttc tctatttgta ttcaggaata
     4261 cctgtgtagt ggttcctgtt gccacaatgt tttggtctga tgcccggtag atggtgtatt
     4321 caaaaaggat tttggcagca tcactatgaa tataccgtgt ctcgacaatg gcttcctcac
     4381 cgaatgacag cggctgtttg aactggcagc tcaggtctac gataggaact aaatagcctt
     4441 cccggtagat gctcatatag tccaagccat atcgctttcc gaaagcttca cgtccatctt
     4501 cgaaataacg cacatattca ccatgccata ctatctgcat ggaatctatt tcactgaagc
     4561 ggaccttgat ggtggtccgg tctgtcagtg ctgcctgctg tggacttgtt tttcgtttca
     4621 ttcttttttc agatatattt tcatccggca ttcggccaga agttcatcgt tttctttcac
     4681 ctcggcggta atcagtgtga tatcgaatat ttcctgcaca atggttattc cggtatataa
     4741 ttctgctccg gcagaaggaa gacggaatat tttcattttt tctacagagc cgataaagcc
     4801 tagtggtaca ggctcttctc gcagcatata gatatatcct acccgtgccg ctgctgattg
     4861 ggcgatgtgt tctatgattc ctgtttcctg taatacgccg tcccggcaaa acagattatc
     4921 gggggtgacg gtcagccctg accaggatgt attttcttct atcccataga aacggtctat
     4981 catgaccatg ggcggacgtt gtggaatcag ccggaacagt tcgtctcccc gacaaatgat
     5041 ttcttttctg ttcatttcag tctgcattgc aggatactgt gtcccagtcc tatgttatca
     5101 tgaatctctt ccacttccag tccggcattt ttaatacagc ggataaggtc atccgaatgg
     5161 aacatcttgc tgttgccgtt ggccatggct gtgaagtaaa ggctgatttg agtcaggcag
     5221 taagagcccg tttcgtatgg ctgccggtcc cacagcgttt ccatgatgta gactttactg
     5281 tctttgctgg cggactgtgc cacacgactt agaatactgg ttgcttcctc ttccgaaaag
     5341 cagtccagaa actggctcat ccatacggtg tcaaagcctg aaggaaaggg cacggtccga
     5401 tccagcagat tggcgccgtg gccatggatg cgttctgcac cgggcacgtc ggcagtttgt
     5461 tttctcatca tttccagttg ttgaggcaaa tccacaatgg ttacttctac ttcttgatta
     5521 tattggacgc atcgggttgc ccatctgccg gtgtttccac caatatcgag cagtcgtttc
     5581 ggtgagtgaa gaaatacaat ttctaatgcc tggctgaacg agttgtccga gtagaaatgg
     5641 tcaaagccaa accagctttt ctgtacctgt tccggcagtt gggaaagtcc ttcgtaaatg
     5701 gtaggccatc cgccgaatac tttcaatcct tccggctgac catttaaaag agcctcttcc
     5761 agatagaaaa gtccttgata gttcacatcg tgattgaatt ccatattgac acgtgccatt
     5821 ttatcattca gcagaaacca gcctgccttg gccagtacat agcggtcttc ttccaacagg
     5881 atggttccga tggtcagcga tgcttccagt aatacttgtg ctgcatagcg tgtcagtccg
     5941 gtctgcacac tgatttcttg cagcgtgtat cctttccgtt tgtcggccag caattggaat
     6001 attccgaatt tcaacatcag acgtgaaact tggaatacca cgggaccgaa agcgatctct
     6061 tgcgccagtc tttgtgcctc tacagctgtc aattgctctt ttgtatatct tttatgcatc
     6121 ataatccaga tttgtattta tgcccagaac gggtagtaat tgaaccattg ttccggatac
     6181 tgccggacga ttttttccag cgtttgtgta tattgctcca ataatgcttg ttcggcccgc
     6241 ttctctttgg tatgtaccac cgcctcggca ataaagaaat ggaaacgata gttttttttc
     6301 gcttcacgca tggcaaaata gaatacgaca ggtactctca ttttggaagc cagcaggaaa
     6361 ggacccatcg gaaattcggc ttcttttccc atgaacggac tgctgagtaa tttctcttta
     6421 ttcagatagc ggtcaccttg aaagcagaca tattctttgc gctccagtgc ctctgtaata
     6481 cggaatacat gggtcagatt gtcttcattc acgggaatta ttttataatc gcgtgtggag
     6541 gcattctttt ccagaatctc ttttatccgt tcgtgttcgg catcaaacat gacaatattg
     6601 atttttttgc cgtattcatc gaagaaagga gcacctattt cccaattacc tacatgggcg
     6661 cctatcataa ttacgccggt gtttccattc agtacgttca aaaatgcctg atagttctcg
     6721 aactcgaaat gatatttgtc tgccatccca ttgccgatgg ctactttgtc aatcaatatc
     6781 tgccccagcc ggtagtaatt tttcaataac agtccggcgg ctttggcacg tccgtatttc
     6841 agtctgttcc gtgcgtattg ccaggtactg gcggtagctt tcggtgcgaa aggtataaaa
     6901 tagaggacga ccaatgacag aaagccgtaa gccgcagtga tacccagaca gcgaatcatg
     6961 tagatgaaga acatgtatcc gaatgtacct cctcttgttt tacctttcca tgtttcgggc
     7021 atcagtcttc tttttgtatg tgcgaaatta ccagattata gaaatcctgg aaggttttga
     7081 taccggcaaa gtctttggct gtcacggtga aaccgaaatt cctgtcaatc agtactacca
     7141 tatctaccaa atcaaggcta tccaattcca aggtttgcat caaaggggcg tccggctgaa
     7201 tcaattctac atcaatctca aattcttcgg ccagggtggt tctgatcttt tcgatgattt
     7261 cttcgttggt cataaattta tatattggtt tgaattaatt gttttcttta aatttacgga
     7321 taatcagtga ggaattggtt cctccgaatc cgaatgagtt ggacaagaag gtgtcaaatt
     7381 ccgtttctat cctccgggag gggatgttca gcagagcaga ggcttcatcg ggttcttcaa
     7441 aattgagatt aggagcgata aatccgttat tcatcatcaa gatggaataa atgacttcac
     7501 tggcgcctgc catccacatc tcatgtccgg tttgtgactt ggtggatgtg acatagggcc
     7561 ggtttccgaa cacttccgct atggcttttg cctcattcaa atctcccacg ggggtggaag
     7621 tggcgtgtgc attgatatat tggatttctt ccaagggaat gcccgcatcg ttgattgcca
     7681 tctgtaatga gcgtctgggg ccgtccacat tcggtacgga aatatgatct ccgttggatg
     7741 aaaaaccgta tcctatgact tctgccagaa tagtagctcc gcgccttacg gctgattcat
     7801 aactttcgag taccaggctg gcgcctcctc cgctgggtac cagaccgtcc cgtcctttgt
     7861 caaaggggcg cgatgccttt tccggttcgt cctcacgggt ggagaacgcg cccaatccgt
     7921 cgaaactacc tacagagtaa ggatttacct cttgtgctcc tccgcacaga atgcagtcct
     7981 gaagtcctga tttgatgagc atatacgcca taccgatggc gtgtgaaccg ctggcacaag
     8041 ctcccgatat ggtaaaatta attcccttca aatggaaaat aaccgaaagg ttcatggtaa
     8101 tcgtagagtt catggactgg aagatagaac cggagcccac catagccgta ttcttcttgg
     8161 cacgaatgac atcaatggcc tcgattaccg gagcggcgct actgtcattt ccatacaata
     8221 tgcctacttc atgatccaat aaaaactcct cgtctatttg tgcctgacgg aatgcctcca
     8281 aggtagccat ataggcatat tctccctgtt cggcgaggct atgccgcttt ttgcggtcca
     8341 ataacttctt taaatcagga cgttcgacaa gtcctgtcaa tgcggaaaaa taccccatct
     8401 ctttacgtgc cggatcgatg ccgatgccgg aacgcccttg gaacaaagag tctttcacct
     8461 catcttggtt cttgcctatg cacgaataaa tacccatgcc tgtaatcact actcttctca
     8521 tcttctgctt atgtatagat tcctccattg atggaaatta cctctccggt gatataggag
     8581 gcttgttccg atgccaggaa gcctaccagt gcggctactt ctccgggttc gccgaaccgt
     8641 cctgccggta tctgtttttt ccattcattt tcatcaatgc cgttggtcat atccgtgcgg
     8701 ataaatcccg gtgctacggc gttcaccgtc acgtgttttc tggccacttc ctgtgccagt
     8761 gctttggtgg cggctatcat tccgcctttg gctgccgaat agttggtttg tcccggcatt
     8821 cctttgatac ccgacaggga aacgatgttg atgatacgtc cgaatcgctt taccagcata
     8881 tttttcagca agggttgggt gacgttgaag aaaccgttca ggctgatatc caacacccgg
     8941 ctccattcat cctgttccat ccacagcatc aggttgtcac ggcgtatacc ggcattgttc
     9001 accagtacct caatgtaggt atcgggatgc ttctccatcc agccgttcag tgcggcgtgt
     9061 gtggctactg cgtctgtcac gtcaaatttc atcagttcgc cgtccgagcc ttgttcccgt
     9121 atctgttgca gggtggcttc ggcttccgta tcgttgcttt ggtagtttat cagtatatga
     9181 tatcccattt cggcca
//
