LOCUS       c00151_gnlPro..        17645 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NAEKIINI_151.
ACCESSION   c00151_gnlPro..
VERSION     c00151_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 18:28:23
            Original ID  :: gnl|Prokka|NAEKIINI_151
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17645
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..243
                     /locus_tag="ctg151_1"
                     /transl_table=11
                     /translation="GYQGKYYGAAGFTYGYSTLLSRHLALEFSLGIGYLTTEYQKYTPY
                     EGSLVWMSSGNYTFIGPTKAKISLVWLITKKRGRK"
     protocluster    1..17645
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4318:7645]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      4319..7645
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..17645
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..17645
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             240..1211
                     /locus_tag="ctg151_2"
                     /transl_table=11
                     /translation="MKKTRYAILVLLSSLLTLVGCSRREILDDYPVTGINIRLNWEGVT
                     DRLPEGVRIIFYPKDGQGRKIDTYLSAKGGEIKVPPGHYSAVIYNYDTEVVQIKDEGSY
                     ETIMACTGSCTGLGAEETKDMVWGPDNFYVATLDDVEIGKEEELPTLEVKPKSVVTTYT
                     FSIKTEGLKNVASILGSVSGMAECYHLGKGASLCRFAPIYCETSKGNGAIKGSFTCFGH
                     PKLTQARADITQFLNLIIVKVDGSKQEAKVEITEAVKPPEDKDEPGGGDEKPQEPEIEI
                     ELPDDEKIVVDDVEIPPDESGGGFDGNVSDWDDETNVELPIG"
     CDS             2002..2247
                     /locus_tag="ctg151_3"
                     /transl_table=11
                     /translation="MLYPQSLTDAKITVKYKTEKDNATFFNGSKEVALTGEWTNGQSIR
                     YILTLPVGAEKMSVNTTYDEDWNATDNEQTPKTPVL"
     CDS             complement(2411..2782)
                     /locus_tag="ctg151_4"
                     /transl_table=11
                     /translation="LDAHCQTCFDYFCDIYAEYLPQGIKEQLDAKNGAVEQLDYLYHEC
                     ERAGQDIYLFIDEYDHFINAILSDVESLHRYTKETHKEGYLRAFFNKIKSGTYSSIKRC
                     FITGVSPVTMDVVVSRGIL"
     CDS             2798..3097
                     /locus_tag="ctg151_5"
                     /transl_table=11
                     /translation="MQFANDTGEIEIQYQVAVPVTCRILPYVEVSKQGVEFILGSYIIV
                     MLQHIQRQTFAETTRTDKEKITVGAFYQRDIHGLVHIIITIKAYIREFHHAVGQ"
     CDS             3408..4322
                     /locus_tag="ctg151_6"
                     /transl_table=11
                     /translation="MSGLPCNERMDCTQCPKAVENSIHYTHNKKGFHLPPHKCETNILF
                     FLLKGQILINSEEYAGTIINPGEFVLQAIASKVEILAMTDSEGILYTFDDPKAFCYDRY
                     TYILKNVPPPLISEPLKIKPEIKLFLEGVTSYLNIDKICKELLEFKRKELYYLLAHYYT
                     DYELSPIVHSLSKYTNSFEYFILKHHKQIKSVEDFAQLGGYSVTTFRRIFKAIFNEPAY
                     EWMMKQRKESILYQLRYTEASISEICFEHGFESLSHFSNFCKKFFGDSPRNIRKREKEE
                     APGKKNAPPKAGHSQISSKTNRD"
     CDS             complement(4319..4801)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg151_7"
                     /sec_met_domain="Fer4_7 (E-value: 2.1e-12, bitscore: 38.1,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 1.7e-07, bitscore: 21.4,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 4e-07, bitscore: 20.9,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRFKDGDTITVEPWRSAGFPVIRDLMVDRSAYDKIMQAGGYVSI
                     NTGGIPDANAIPIAKPIADEAMDAAACIGCGACVAACKNGSAMLFVSAKVSQLALLPQG
                     KVEAARRAKAMLSKMDELGFGNCTNTRACEAECPKLVSISNIARLNREFIAAKLKD"
     CDS             complement(5095..7059)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 193.8; E-value:
                     1.8e-59)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg151_8"
                     /sec_met_domain="FAD_binding_2 (E-value: 6e-60, bitscore:
                     193.8, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 6.4e-38,
                     bitscore: 120.2, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNMATIDSKIPEGALAEKWTNYKAHQKLVNPANKRRLDIIVVGTG
                     LAGASAAASLGALGFKVLNFCIQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTI
                     KGGDYRAREANVYRLAEVSNAIIDQCVAQGVPFAREYGGLLDNRSFGGAQVSRTFYARG
                     QTGQQLLLGAYSALSREVQRGNVKLYTRYEMLDVVLIKDNEGVERARGIIARNLVTGKI
                     ERFAAHAVVIGTGGYGNTYFLSTNAMASNGSAAMQVYRKGAYFANPCFAQIHPTCIPVH
                     GDKQSKLTLMSESLRNDGRIWVPKKLEDAKALQAGTKKPTDIPDADRDFYLERRYPAFG
                     NLVPRDVASRAAKERCDAGFGVNNTGLAVFLDFKYAIDRLGEDVVRARYGNLFDMYEEI
                     TDENPYKTPMMIFPAIHYTMGGIWVDYELMTSIKGLYAIGEANFSDHGANRLGASALMQ
                     GLADGYFVLPYTIQNYLSDQIQVPRFSTDLPEFVAAEKAVNDKIQRLMNIKGHRSVDSI
                     HKELGHIMWDFVGMGRTKESLTTALAKLKEVRKTFWSDLRIPGEANELNVELEKAIRLA
                     DFIEIGELMAYDALNREESCGGHFREEHQTPEGEALRHDDKFSYVACWKYTGEGKEPEL
                     IKEDLNYQFVKVQTRNYKS"
     CDS             complement(7088..7645)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg151_9"
                     /sec_met_domain="SucD_FumR (E-value: 2.7e-99, bitscore:
                     321.0, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MICEFLGANWYALVATAGLAALFVIHIIYAFWLTMQNRAARGSER
                     YAVNVKPKTVEWASQNMLVLGIIVIAGLALHFANFWYKMQFAEIIGVHDLGAFGPTDGA
                     AYIRETFGCPVFTVLYLIWLAALWFHLTHGFWSALQTLGWSNKIWFERWKTIGNIYSTL
                     VVLGFAAVVVIYFVKSLACGAC"
     CDS             8048..8575
                     /locus_tag="ctg151_10"
                     /transl_table=11
                     /translation="LKTINKWKVHGLSRGLSASGVILPVGVPAAMGLYALIKKDQPMLK
                     DAVYIGTSVIEAVGITYAAKHIIGRDRPFVKYPDKIHAYGAPDADSPSFPSGHTAAAFS
                     LATSLSITYPKWYVIAPSAVWACGVGFARMNQGVHYPSDVVAGAAIGVGCAFANIYVNR
                     WLNKVLFGRQIK"
     CDS             complement(8630..10231)
                     /locus_tag="ctg151_11"
                     /transl_table=11
                     /translation="MKYTMYFAGLIACFFSIVAVQAQENKFLNSPARKLQLAEFAIANL
                     YVDEVNEGKLVEEAIVKMLEQLDPHSTYSDPEEVKKMNEPLQGNFEGIGIQFNMAEDTL
                     LVIQPVSGGPSEKAGILAGDRIVMVEDTLIAGVKMSTEDIMRRLRGPKDSKVNLKILRR
                     GVKELLPFTVKRDKIPVYSLDASYMIKDKIGYIRINRFAATTHEEFKKALAELQKKGMK
                     DLILDLQGNGGGYLNAAIDIANEFLGKKELIVYTEGRRNPRSEFFAKGTGEFQNGRLIV
                     LVDEFSASASEIVTGAVQDWDRGVVVGRRSFGKGLVQRPIDLPDGSMIRLTVARYYTPA
                     GRCIQKPYESIEKYNEDLIDRYNKGEMMSEDSIHFPDSLKFKTHKLARTVYGGGGIMPD
                     YFVPIDTTLYTKYHRQLRDKGALMKAHFHFIDAHRKEWLGKYKTFNEFYKRFEVTPDML
                     AQLVATGKEMGVEYNEEEYQKALPLLKLQMKALIARDLWDMNEYYHVINDANESIRKAL
                     ELLEQPDFEGLLLKKR"
     CDS             complement(10234..10710)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CTP_transf_like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg151_12"
                     /sec_met_domain="CTP_transf_like (E-value: 4.8e-23,
                     bitscore: 72.4, seeds: 65, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LRESLTNMRRAIFPGTFDPFTIGHYSVVKRALTFMDEVVIGIGIN
                     ENKKTWFPTEKRVEMIEKLFADDPRVKIDAYDCLTIDFARAKEAQFIVRGIRTVHDFEY
                     EETIADINRKLAGIETILLFTEPELTSISSTIVRELLQFGKDVTPFLPEGMKID"
     CDS             complement(10703..12580)
                     /locus_tag="ctg151_13"
                     /transl_table=11
                     /translation="MEENNELINNPAVEYTDDNIRHLSDMEHVRTRPGMYIGKLGDGSH
                     AEDGIYVLLKEVLDNSIDEFKMQAGKKIEIIIEENLRVSVRDYGRGIPQGKLIEAVSVL
                     NTGGKYDSKAFKKSVGLNGVGVKAVNALSSRFEVRSYRDGKVRIATFAKGDLLTDTTQN
                     TTEENGTYIFFEPDNLLFENYSFRPEFVETMLRNYTYLNTGLAIIYNGQRILSRNGLVD
                     LLNDNMTAVGLYPIIHLKGEDIEIAFTHTGQYGEEYYSFVNGQHTTQGGTHQSAFKEHI
                     ARTIKEYFNKNMDYSDIRNGLVAAIAVNVEEPLFESQTKIKLGSTNMAPGGPTVNKFVG
                     DFVKTEVDNYLHKHTDVADVMLQKIQESEKERKAIAGVTKLARERAKKANLHNRKLRDC
                     RFHLNDVKGDKKEESCIFITEGDSASGSITKSRDVNTQAVFSLRGKPLNSYGLTKKIVY
                     ENEEFNLLQAALNIEDGMEGLRYNKVIVATDADVDGMHIRLLLITFFLQFFPDLIKKGH
                     VYILQTPLFRVRNRKKGVYETVYCYSEEERIAAIERLSPNPEITRFKGLGEISPDEFKH
                     FIGKDMRLEQVSLRKTDLVKELLEFYMGKNTMERQNFIIDNLVIEEDIA"
     CDS             complement(12611..13747)
                     /locus_tag="ctg151_14"
                     /transl_table=11
                     /translation="MAITIKKVSSKKELKTFIRFNYELYKENPYSVPDLYDDMLNTFSP
                     KKNAAFEFCEAEYFLAYKDNKVVGRIAGIINKRANETWNKKEVRFGWIDFLDDIEISRA
                     LLDAVAQWGKSKGMDTIQGPLGFTDFDAEGMLIEGFDQLSTMATIYNYPYYPQHMEKLG
                     FEKDADWVEYKIYIPDAIPDKHKRISDLIQRKFNLKVKKYTSGKKIAAEYGQAIFELMN
                     EAYAPLYGFSALSQGQINQYIKMYLPIVDLRMVTLVTDAEDKLVAVGISMPSLSEALRK
                     AKGRLLPMGWYHLLKVLFLHKYPPMLDLLLVAVKPEYQNKGVNALLFSDLIPVYQQLGF
                     KYAESNPELELNGKVQAQWEYFKTEQHKRRRAYKKSIL"
     CDS             complement(13823..14818)
                     /locus_tag="ctg151_15"
                     /transl_table=11
                     /translation="LRCKTVNVLFVMLNTLLLIGGLALILAGANGLTDGSAAVAKRFRI
                     SDLVIGLTIVAFGTSAPELVISVLSALNGSAEMAIGNVVGSNIFNALMIIGCTALVLPI
                     KVGEGTMSKEIPLVILSSLVLFVCANDMMLDREAVNVISRSDGFVLLAFFLIFMRYTFA
                     IARNGADEAGEEQKIKEMPVWKSVLYIAGGLAGLIFGGQLFVDGASGLARSWGVSESVI
                     GLTLVAGGTSLPELATSVTAALKKNPGIAIGNVIGSNLFNIFFVLGCSATVSPLPMGNI
                     NNLDLSVLIASSLLLWLVGWFFRKRTITRLEGALMVGCYVVYTAYLIAQQ"
     CDS             complement(14849..15820)
                     /locus_tag="ctg151_16"
                     /transl_table=11
                     /translation="MKTLMMIRKMKEVLTWVWIVVIGAAICLNVCAQTPQDWKGLEKQL
                     NFYMANDLGRNGYYDQKPIAELMGEMADVIGPECVFAAGDVHHFEGVRSVNDPLWMTNY
                     ELIYSHPELMIDWFPILGNHEYRGNTQAVLDYTNVSRRWSMPGRYYTKVFEKKGTAIRF
                     VMIDTAPLIDKYRNESETYPDACKQDMDKQLAWIDSVLTAAKEDWVVVIGHHPIYAETS
                     KDDSERSDMQKRLDPILRKHKVDIYACGHIHNFQHLRVPGSDIDYVVNSAGSLSRKVKP
                     VEGTQFCSPEPGFSIFTADKKELDMHMIDKKGKVIYTVKRTK"
ORIGIN
        1 ggctaccaag gtaaatatta cggtgcggca ggattcactt atggatattc cactttgttg
       61 tcacgacatc tggcattgga attcagccta ggcataggct atctgaccac ggaatatcaa
      121 aaatatactc cctatgaggg atcactagtc tggatgagta gcggaaatta cacctttata
      181 ggccctacga aagcaaaaat ttcgttggta tggttgataa ccaagaaaag aggaagaaaa
      241 tgaaaaagac aaggtacgca attcttgtac ttttatcttc actattgact ttagtgggat
      301 gcagccgccg cgagattctg gacgattacc ccgtaacagg aataaacatc cgtctgaatt
      361 gggaaggagt aaccgaccgt ctgccggaag gagtccggat catcttctat cccaaggacg
      421 gccaaggaag gaagattgat acctacttat cggcgaaagg cggagaaata aaagtacctc
      481 cgggacatta ttcggcagtg atttacaatt atgacaccga agtagtgcaa ataaaagacg
      541 aaggtagcta cgaaacaata atggcatgta caggaagctg tacgggactg ggtgccgagg
      601 aaacgaaaga catggtatgg ggaccggata atttttatgt agcaaccctg gacgatgtag
      661 agataggaaa agaggaagaa ttaccgacac tagaggtaaa accaaaatct gtggtaacca
      721 cttacacttt ttcaataaag acagaagggc tgaaaaatgt tgcatccatc ctgggcagtg
      781 tttccggaat ggctgaatgt taccacctgg gcaaaggagc cagcctatgc cggttcgctc
      841 ctatttattg tgaaaccagt aaagggaatg gggctataaa agggagtttt acctgctttg
      901 ggcatcccaa actgacgcaa gcaagagccg atatcactca gtttctgaac ttgattatag
      961 taaaagtgga tggttccaaa caggaagcga aagtagaaat aacggaagcg gtaaaacctc
     1021 ctgaagataa agacgaaccg ggaggaggtg atgaaaaacc tcaagagccg gagatagaga
     1081 tcgaacttcc ggatgatgag aagattgtgg tggatgatgt agagattcct cctgatgaaa
     1141 gtggcggtgg atttgatggg aacgttagtg actgggatga tgaaacgaat gtagaattac
     1201 cgatcggtta aaatatagaa taaagagtca tagaattatt aacttaaaac ataggatatg
     1261 aagaagattt tatttgcagc tttagctgca ttggcaatca caagttgctc acagaatgag
     1321 attgatggta ttgacaatgg aactccaaaa agtaaaaatg agataggagt aaacacgatt
     1381 gtcaaaaaga gttcaagggc cactgttaca agtaatagta gtttcacgtc ttttaaatta
     1441 catgcctata taattaaaag cagcgatatc gccacttcag gatggggtaa cgcgtatatg
     1501 gatggcatag aatataaagg aggtcaaggt aattggacta caacaagtgg tactttttat
     1561 tggcctataa cagaaatgca attttttgga tataccgatg atgtaaccta tacagcacct
     1621 gctagttcca gcgcttatcc caccatcagc tatacccttc ctgatacccc ggccgatcag
     1681 aaagatatta tagtagctta ttccaaagat ataactaagc caagtgataa tacattaaac
     1741 cttacattcc aacacatctt aacccgtata aactttgctg caaaactagc tgacagcaac
     1801 tatacttaca cagttgaaag cataactatc accggtgcaa aaggtggtgc tgcaacgtac
     1861 acattcggag gaactgaagg aaaaggtgga aattggaata tcacaggaag tgcacctgct
     1921 agtggttata gctatacatt tgataacacc gtaacagcca aagatgatat ttatgattat
     1981 acacaaaata ataattcatt aatgctgtac ccacaatctc ttactgatgc taaaattaca
     2041 gtcaagtata aaacagagaa agataatgca acattcttta acggatcaaa agaagtagct
     2101 ttaacaggag aatggactaa tgggcaaagt atccgctata tactaacttt accggttggt
     2161 gcagaaaaaa tgagtgtaaa cacaacatat gatgaagatt ggaatgccac tgataacgag
     2221 caaactccta aaactcctgt attataagaa accaacaaac tataaattaa tgaatttaca
     2281 aatcccccga caaacataca gataaacata acaattcccc gctccgcaat gaaacaccgc
     2341 atcatcccct ctatcatttg cgatttcatt tgcggagcat ttttacctgt tgacaatcag
     2401 ccgtcctcaa tcataaaata cccctagaaa caaccacatc catcgtcaca gggctgactc
     2461 cggtaatgaa acagcgtttg atgctggaat aggtaccgga ttttatcttg ttgaagaatg
     2521 cacgcagata tccttccttg tgcgtttcct tcgtatatcg gtgcaggctt tcgacatccg
     2581 aaaggatggc attgataaaa tggtcatact catcgataaa aagataaata tcctgaccgg
     2641 cacgctcaca ctcatgataa agatagtcta attgttctac cgccccattc tttgcgtcca
     2701 actgttcttt gataccctgc ggcaggtatt ccgcataaat atcacagaaa tagtcgaaac
     2761 aggtttggca atgtgcgtcc aatccggcac gatagttatg cagttcgcca atgataccgg
     2821 agaaattgag atacaatacc aagtagctgt tccagtcacg tgtaggatac ttccctatgt
     2881 agaggtctcc aaacagggcg tcgaatttat ccttggttcg tacatcatag taatgttaca
     2941 gcatattcag cgtcagactt ttgccgaaac gacgcggacg gataaagaaa aaataacggt
     3001 tggagcgttc tatcaacggg atatacatgg tcttgtccac ataataataa ccatcaaggc
     3061 gtatatccgc gaatttcatc atgccgtagg gcaataattt cttatctgat gatactacaa
     3121 attccataat ctatgctgtt ttagccggta tacctcccca tggggtacac acaaagatac
     3181 tttctttctg ctactttccc aacaattgca acttcttttt gtttggccac acaaatttag
     3241 ccctctatgc tcatgcccac aggctatcgt tttccgtaac ggcagaagac aaacaagtgg
     3301 aaacaggatt cttcggtctt tttcttgaaa cttattgcaa attatccata tttgacctac
     3361 atttgtcaaa tcaaaaaaaa gaacacaagc gtctctaaca tctatatatg tctggtctgc
     3421 cctgtaatga aaggatggat tgtacccaat gccctaaagc agtggagaat agcatccatt
     3481 acacacataa caaaaaaggt ttccacttac ccccacataa gtgtgaaact aatatcttat
     3541 ttttcttact caaaggccaa atactcatca atagtgaaga atatgccggt actatcatca
     3601 atcccggaga atttgtactg caagctatcg catcaaaagt ggaaatactg gccatgacag
     3661 actcggaagg tattctgtac acattcgatg accccaaagc tttctgttat gaccgctata
     3721 cctatatatt gaaaaacgtg cccccgccac tcatctccga gccacttaaa ataaagcccg
     3781 aaataaagct tttccttgaa ggagttacct cctatctgaa tatagacaaa atctgtaaag
     3841 aactgcttga attcaagcgt aaagaactgt attatctact ggcgcactac tatacagact
     3901 atgagctttc ccccattgta cacagtttgt ccaagtatac caacagcttt gaatatttta
     3961 tattaaaaca ccacaagcaa ataaagtctg tagaagactt cgcacaactg ggcggctata
     4021 gcgtcaccac cttccgccgt attttcaagg ctatcttcaa cgaaccggcc tatgaatgga
     4081 tgatgaagca gcgcaaagaa agtatcctct accaattgcg ctatacagag gcttccatct
     4141 ccgaaatctg cttcgaacat ggattcgaat ctctctcaca tttctccaac ttctgtaaga
     4201 agttctttgg cgattctccc agaaacatac gtaagagaga aaaagaagaa gccccaggca
     4261 aaaaaaatgc cccaccaaag gcagggcatt ctcaaatatc aagtaaaact aaccgtgatt
     4321 agtctttcag cttcgcagca ataaattcac ggttcaaacg agcgatgttg ctgatagaaa
     4381 ccaacttcgg acattctgcc tcacaagcac gagtgtttgt acagttacca aagcccagtt
     4441 catccatctt gctcaacata gctttcgcac ggcgtgcagc ttccacttta ccctgaggta
     4501 acagtgccaa ctgactgacc tttgcagaaa caaacaacat ggcagaacca ttcttacatg
     4561 cagcaacaca agcaccacaa ccgatacatg cagcagcatc catagcctcg tcagcaatag
     4621 gttttgcaat aggaattgcg ttagcgtcag gaataccacc ggtattgatt gacacgtaac
     4681 caccggcctg cataattttg tcgtatgcgc tacggtctac catcaagtcg cggattaccg
     4741 ggaaaccggc agaacgccaa ggctcaacag taatggtgtc accgtctttg aaacgacgca
     4801 tataaatctg gcaggtagta gcacctgtag caggtccgtg aggatgtccg ttgatataca
     4861 tagagcacat accgcagata ccttcgcgac agtcgtggtc gaatacgata ggttctttac
     4921 cttcattgat aagctgctcg ttcaagatgt ccatcatttc caggaatgag gtatcacccg
     4981 gaatatcttt catttggaag gtatcaaaat gtcctttgtc cttaggacct ttctgacgcc
     5041 aaactttcag tgtgaaactt atatttttat ccatgatttc tatacaatta ataattaaga
     5101 cttatagtta cgagtttgaa ccttaacgaa ctgatagttc aaatcttcct tgatcaattc
     5161 gggttctttt ccttcaccgg tgtatttcca gcaagctaca tacgagaact tgtcatcgtg
     5221 acgaagtgct tcaccttccg gagtctggtg ctcttcacgg aagtgaccac cacaagattc
     5281 ctcacggttc aatgcatcgt aagccatcag ctcaccgatt tcgatgaaat cagccaggcg
     5341 gattgccttt tcaagttcta cattcaattc attagcttca cccggaatgc gaaggtcgct
     5401 ccagaaggtc tttcttactt ctttcagttt agccagagca gtagtcaaag attccttggt
     5461 acgtcccata cctacaaagt cccacatgat gtgacccagc tccttgtgaa tagagtctac
     5521 agaacgatga cccttgatat tcatcagtct ctggatctta tcgtttacag ccttttcggc
     5581 agctacgaat tcgggaaggt ctgttgagaa acggggaacc tgaatctggt ctgacaaata
     5641 gttctggata gtgtaaggca atacgaagta accgtcagcc aatccctgca tcaatgcaga
     5701 tgcacccaaa cggtttgcac cgtggtcaga gaagttagct tcaccgatag catacagacc
     5761 cttgatagag gtcatcagtt catagtcaac ccagatacca cccatcgtat aatggatagc
     5821 cgggaagatc atcatcggag ttttatacgg attttcatca gtgatttctt cgtacatatc
     5881 gaacaagtta ccgtaacggg cacgaactac atcttcaccc agacgatcga tagcatactt
     5941 aaagtcgagg aatacagcca aacctgtgtt gttcacaccg aaacctgcgt cgcaacgttc
     6001 tttcgcagca cgtgaagcaa cgtcacgagg aaccaagtta ccgaatgccg gataacgacg
     6061 ttccagatag aagtcacggt ctgcatcagg tatatcagtc ggtttcttag ttcctgcctg
     6121 caatgccttg gcatcttcca gctttttcgg aacccagata cgtccgtcat tacgcaatga
     6181 ctcagacatc aaagtcagtt tagactgctt gtcaccgtgt acaggaatac aggtcgggtg
     6241 gatctgtgca aaacaaggat tagcaaaata agcacctttg cggtaaacct gcatagcagc
     6301 cgatccattt gacgccatag cgttggtaga caagaaataa gtattaccat aaccaccggt
     6361 accgattact actgcgtgag cagcaaaacg ttcaatctta cctgtaacca agttacgggc
     6421 aatgatacca cgggcgcgtt ccacaccttc gttatcctta atcagcacaa cgtccaacat
     6481 ttcataacga gtgtacaatt tcacgttacc acgctgaact tcacggctca atgcagaata
     6541 agcacccaac aacaactgct gtccggtttg gccgcgggca tagaatgtac gtgatacctg
     6601 agcaccaccg aatgaacggt tgtcaagcaa accaccgtat tcgcgagcga aaggaacacc
     6661 ttgagctacg cactggtcga taatagcatt tgacacttcg gccagacggt aaacgttggc
     6721 ttcgcgtgca cggtagtcac cacctttaat tgtatcatag aaaagacggt aaacggagtc
     6781 accatcattt tgataattct tagcagcatt gatacctccc tgtgcagcga tggagtgtgc
     6841 acgacgggga gagtcctgga tacagaagtt taataccttg aaacccagag cacccagtga
     6901 agcagcagcc gaagcacctg ccaaaccggt acctaccaca ataatgtcaa gacgacgttt
     6961 gttggcaggg tttaccaatt tttgatgagc tttataattg gtccatttct cggctaaagc
     7021 gccttcagga attttagaat ctatagtagc catattcatt tacaatttta tcatttacaa
     7081 tttacgatta gcaagcacca caagcgagtg attttacgaa gtagataacg actactgctg
     7141 caaaaccaag aactaccaaa gtagagtaga tgttaccaat agtcttccaa cgctcgaacc
     7201 agattttgtt gctccagccc aatgtctgca aagcgctcca gaatccgtga gtcaggtgga
     7261 accataaagc tgctaaccaa atgaggtaaa gcactgtaaa tacagggcat ccgaatgttt
     7321 cacggatgta agcggcaccg tctgtagggc cgaacgcacc taaatcatga acaccgatga
     7381 tttcggcaaa ctgcattttg taccagaaat tggcaaagtg aagagccaat ccggcaatga
     7441 cgataatacc caggacaagc atgttctgag atgcccattc cacagtttta ggtttaacgt
     7501 tcactgcata gcgttcgcta ccacgagctg cacggttctg catggtcaac cagaaagcgt
     7561 agatgatgtg gattacgaac agagcagcca gtccggcagt tgcaaccaac gcgtaccagt
     7621 tagctcccaa gaattcacaa atcatgttgt aagcatcttc cgagaagagc gcaacaaggt
     7681 tcatcgccat gtgaaacgtc agaaacagga caagggcgat acctgtgaca ctcatcacca
     7741 ctttccttcc aatagatgaa ttacttaacc acataaatga ttgaatttaa attatttaat
     7801 tgttagaact aaaaattctg ttaaaagctg tgtattcacg atgcaaaagt aaaggaattc
     7861 tagcgataat acaaggaatt atggaaatta ttctttaatt cgggaagggt aaatgcgaat
     7921 tacattattt ttctatcttt gtaccgaaca aaaaccaaac aaaatggata tacgaagaat
     7981 tattttcctc ttgttgacag taagttttac attcagcctc ccggcccaga atatagatat
     8041 caacacattg aaaaccatca ataaatggaa ggtacacggc ctcagcagag gactatccgc
     8101 cagcggagtg attctgcccg taggagtgcc tgccgccatg ggactctatg cattgataaa
     8161 gaaagaccag ccgatgctga aagatgccgt ttacatagga accagtgtga ttgaggcggt
     8221 aggtatcaca tacgctgcca aacatatcat aggacgtgac cggccttttg taaagtatcc
     8281 ggataagatt catgcatacg gagcaccgga tgcagacagc ccgtcgtttc cttcaggaca
     8341 cacagccgcc gctttttccc tggcaacttc gctttctatc acttatccca aatggtatgt
     8401 catcgctcct tctgccgtat gggcctgtgg agtggggttt gcacgaatga accaaggagt
     8461 gcattatccc agtgatgtag tggcaggagc agcgatcgga gtaggatgtg cttttgcaaa
     8521 tatttatgta aaccgatggc tgaataaggt gctgttcggg agacagataa agtgatggtt
     8581 ggatgcagga gtgcaactat gcgcccctgc agttaatata aagtcttgac tatcgttttt
     8641 ttagcagcaa tccttcaaaa tccggttgtt ccagcagctc cagtgctttc ctgatacttt
     8701 cattggcatc attgatgacg tgataatact cattcatatc ccataaatca cgggctatca
     8761 atgctttcat ctgcaatttc agcaaaggaa gggccttctg gtattcttct tcattatatt
     8821 ccactcccat ctccttgccg gtagcaacca gttgtgccaa catatccgga gtcacttcaa
     8881 aacgtttgta gaattcattg aaagtcttgt atttgcccag ccattcttta cgatgggcat
     8941 caataaaatg aaagtgagct ttcatcaacg cccctttatc acgcaactga cgatgatatt
     9001 tagtatagag agtcgtatca atcggcacaa aataatcggg cataattccc ccaccgccat
     9061 ataccgtacg agccagctta tgagttttga acttcagtga atccgggaag tgaatgctgt
     9121 cttcactcat catctctcct ttattataac ggtctatcag gtcctcatta tacttttcaa
     9181 tgctttcgta aggtttctgg atacaacgtc cggcaggagt ataataacgg gccaccgtca
     9241 aacgaatcat cgacccgtcc ggcaaatcaa tgggacgctg caccaagcct ttaccaaagc
     9301 tgcgccggcc cacaacgact cctctgtccc aatcctgaac agctccggtc acaatctcac
     9361 tggcagaagc cgagaattca tcgaccaata caatcagacg accattctgg aactcgcccg
     9421 tacctttagc aaaaaattca ctacggggat tacgacggcc ttccgtatag actatcagtt
     9481 cctttttgcc cagaaactcg ttggcaatat cgatggcagc gttcaaataa cctccgccat
     9541 tgccttgcaa atcaagaatc aaatctttca tccctttttt ctgcaattca gctaacgctt
     9601 tcttgaactc ttcatgggta gtggcggcaa aacggttgat acggatataa ccaatcttat
     9661 ctttaatcat ataggaagca tccaggctgt aaacaggtat tttatccctt ttcaccgtaa
     9721 aagggagcag ttccttcacc cctcggcgaa gtattttcaa attcactttt gaatctttag
     9781 gaccacgaag acgacgcatg atatcttcgg tgctcatctt tacaccggct atcagcgtat
     9841 cttccaccat gacgatacga tcgccggcca gaatacctgc tttttcggaa ggaccgcccg
     9901 atacgggctg tatcaccaac aatgtatctt ctgccatatt gaactgtatg ccgatacctt
     9961 caaagtttcc ctgcagcggc tcgttcattt tcttcacttc ctccgggtcg gaataagtag
    10021 aatgaggatc aagctgttcc agcattttta cgatggcttc ctctacaagt ttcccctcat
    10081 tgacttcgtc tacataaagg ttggcaatgg caaactccgc caactgtaat ttgcgtgccg
    10141 gagaattcag aaacttattt tcctgagcct gtacggctac aatagaaaaa aagcaggcaa
    10201 tcaagcctgc aaagtacata gtatatttca tgatcagtct attttcattc cttcaggtaa
    10261 gaatggtgtt acgtctttac caaactgcaa taattctctc acaatagtag agctgataga
    10321 agtaagttcc ggctccgtaa ataacagaat agtttctata ccggccagtt tccggttgat
    10381 atcggctatg gtttcctcat attcaaaatc gtgtacggtg cggattccac gaacaatgaa
    10441 ctgcgcttct ttagctctgg caaagtctat ggtcaaacaa tcgtaagcgt cgatctttac
    10501 ccggggatca tcagcaaaaa gtttctcaat catctccact cgtttctctg taggaaacca
    10561 agtcttctta ttctcattga taccgatacc gattaccact tcatccataa aggtcaatgc
    10621 tcttttcacg accgaataat ggccgatggt aaagggatca aatgtccccg gaaatatggc
    10681 tcttctcata tttgttagtg attcacgcaa tgtcttcttc tataacaagg ttatctataa
    10741 taaaattctg acgttccatg gtgttcttac ccatataaaa ctccagcaat tctttcacca
    10801 ggtcagtctt gcggagggaa acttgctcca gacgcatgtc tttgccgata aagtgcttga
    10861 attcatcggg tgagatctct cccaaacctt tgaatcgggt aatttcggga ttggggctta
    10921 accgttcgat agcggcaatc cgttcttctt ccgaataaca atatacggtt tcataaactc
    10981 ctttcttgcg gttgcggaca cggaataaag gggtttgaag gatatataca tgacctttct
    11041 ttatcaagtc agggaagaat tgcaggaaga aagtaataag caataaacgg atgtgcatac
    11101 cgtctacatc agcatctgta gctacaatta ccttattata tcgtaatcct tccataccgt
    11161 cctctatgtt cagagcagcc tgaagcaggt taaactcttc attctcatat acaatcttct
    11221 tggtcagccc gtaagaattc aacggcttac cacgcaaact gaatactgcc tgagtattta
    11281 catcacggct cttggtgata gaaccgcttg ccgagtctcc ctcggtaatg aagatgcagc
    11341 tttcctcctt cttgtcccct ttgacatcgt tcagatgaaa gcggcagtca cgtaacttcc
    11401 ggttatgaag atttgccttc ttggctcgct cacgtgccag tttcgtcact ccggctatcg
    11461 ctttacgctc tttctccgac tcctgaatct tctgcaacat cacatcggcc acgtccgtat
    11521 gcttgtgcag atagttatcg acctcagtct ttacaaaatc acctacaaat ttattgacgg
    11581 taggaccacc gggagccata ttggtagagc ccagcttgat tttagtctga ctttcgaaca
    11641 acggttcctc cacattgacg gcaatggcag ccaccagtcc gttacggata tcggaataat
    11701 ccatgttctt gttgaaatat tccttgatgg tacgggcaat atgctctttg aaagcacttt
    11761 gatgcgtacc tccctgagtc gtatgctgtc cgttgacaaa agagtaatac tcttcaccat
    11821 actggccggt atgcgtaaag gctatctcaa tatcttctcc cttcaaatgg atgatgggat
    11881 ataatcccac agccgtcatg ttgtcgttaa gcaaatccac caacccgtta cgggacaaga
    11941 tacgctgacc gttatagata atggccagtc ctgtattcag ataggtataa ttgcggagca
    12001 tggtttccac aaactccgga cggaaactgt aattctcaaa taacaggtta tccggttcaa
    12061 agaaaatata agtaccgttc tcctctgttg tattttgtgt ggtatccgtc aacaagtctc
    12121 ccttggcaaa ggtagcgata cgcacctttc catcacgata gctgcgcacc tcgaagcgcg
    12181 aactcaatgc gttgacagct ttcacaccga ccccattcag tccgacactc ttcttaaacg
    12241 ccttactgtc atatttacct cccgtattca gcacacttac agcctcaata agttttccct
    12301 gcggaatacc ccgaccatag tcacgcacgc tgacacggag attttcttca atgataatct
    12361 caatcttttt acccgcctgc attttgaatt catcgatact gttgtcgaga acttctttca
    12421 gaaggacgta gataccgtcc tcggcatgtg atccgtcacc caactttcca atatacatac
    12481 cgggacgggt acgcacatgc tccatgtcac tgaggtggcg gatgttatcg tcggtatatt
    12541 ctacagcggg attgtttatc agttcgttgt tttcttccat attgacttat cacattttta
    12601 tatatcgttg ttacagaata ctctttttat aagcacgacg gcgtttatgc tgctcggtct
    12661 tgaaatattc ccactgggcc tgcacctttc cattcagttc cagttccgga ttactttcgg
    12721 catacttgaa tcccagttgc tgatatacag gaatcaagtc cgagaataac aaagcattga
    12781 ctcctttgtt ctgatactca ggttttacag caaccagcaa caagtccagc atagggggat
    12841 atttatgcaa aaacagcact ttcagcaaat gataccagcc cataggcagc aaacgcccct
    12901 tcgcttttcg taacgcttcg gacaaagaag gcattgaaat acccaccgcc accagtttat
    12961 cttcagcatc ggtcaccaag gtcaccatac gcaaatctac aataggcaaa tacatcttta
    13021 tatactggtt aatctgtcct tgagacaaag ccgagaaacc ataaagcgga gcataagcct
    13081 cattcatcaa ttcgaagata gcctggccat attcggccgc aattttctta cccgatgtat
    13141 atttcttcac cttcaagtta aacttacgtt gaatcaaatc actgatacgc ttatgcttat
    13201 caggaattgc atccggaata taaattttat attccaccca atcggcatcc ttttcgaatc
    13261 ccaacttctc catatgctgt ggataataag gataattata gatagtcgcc atggtgctca
    13321 attggtcgaa tccttctatc agcataccct ccgcatcaaa gtcggtaaag cccaaaggtc
    13381 cctgaatggt atccattccc ttcgatttac cccattgggc tactgcatcc aacaaggcgc
    13441 gtgatatttc gatatcatcc aggaaatcaa tccatccgaa acggacttct tttttattcc
    13501 aagtttcgtt tgcgcgttta tttataatcc ctgcaatacg tcctaccacc ttgttatcct
    13561 tatatgccag aaaatactcc gcctcacaaa actcgaaagc ggcattcttc ttcgggctga
    13621 acgtattcag catatcatcg tacaagtcgg gtacggaata aggattctct ttgtataact
    13681 cgtagttgaa ccgtataaat gtcttaagtt ctttctttga actgactttt ttaatggtaa
    13741 tagccatgct gtatttttat aaaaattcag ggtgtaaaga tagaagtttt tttgcagata
    13801 acttattctt tttatggctt ttttactgtt gggcaataag ataggcggta taaacgacat
    13861 aacagccaac catcaatgcg ccttcaagac gggttatggt acgtttacgg aaaaaccagc
    13921 ctaccagcca caacaacagg gaggaagcaa tcagcacact taaatcgaga ttatttatat
    13981 tccccatcgg aagcggtgat accgtagcgc tgcaccccag tacaaagaat atattgaaca
    14041 gattgctacc gatgacattg ccgatagcaa ttcccggatt cttctttaaa gctgccgtaa
    14101 cagatgtagc aagctccggc aaggaagtac ctccggctac caatgtcagt ccgattaccg
    14161 attcactgac accccatgaa cgggcaagcc cgcttgcccc gtcgacaaaa agctgtccgc
    14221 caaatatgag cccggccagt cctcctgcaa tatacaacac cgatttccat acaggcattt
    14281 ccttaatctt ctgctcttct cctgcctcat ctgccccatt acgagcgata gcaaatgtat
    14341 aacgcataaa tataaggaag aaagccaaca gaacaaaccc atcggaacgg ctgataacat
    14401 tgaccgcttc cctgtccagc atcatgtcat tggcacagac aaacagtacc aatgaagaaa
    14461 gaatgactaa cggaatctct ttactcatcg tcccctcacc tacttttatg gggagtacca
    14521 acgcagtaca gcctataatc atcaaagcat tgaatatatt actacccacc acattaccaa
    14581 tagccatttc agcactgcca ttcaatgcag aaagcacact gataaccaat tcgggagccg
    14641 aagtgccaaa agctacaatg gtaagcccga ttaccaaatc agaaatacgg aaacgtttgg
    14701 caaccgctgc agaaccatct gtcaagccat ttgcaccagc caaaataaga gccagaccac
    14761 caatcaaaag gagtgtattc aacataacaa agagtacatt tacagtttta caccgcaaat
    14821 gtactctttt tccctaaaat aactatccct atttggtgcg ttttacagta tagattactt
    14881 ttcctttctt atcaatcata tgcatatcca gttctttctt gtctgccgtg aagatagaaa
    14941 agcccggttc gggactgcag aactgagtgc cttccactgg ttttacctta cggctcaacg
    15001 aacctgccga atttaccaca tagtcgatat cactgcccgg cacacgaaga tgctggaagt
    15061 tatgaatgtg tccgcatgca tagatatcca ccttatgttt acggaggata ggatccagac
    15121 gtttctgcat atcgctgcgt tcactgtcgt ctttcgacgt ttcagcataa atgggatgat
    15181 gccctattac gacaacccaa tcttctttgg cagcagtaag cacagagtct atccatgcca
    15241 gttgcttgtc catgtcctgt ttgcaggcat ccggataagt ttcgctctcg ttacggtatt
    15301 tgtcaatcag aggagcggta tctatcatca caaaacggat ggcagttcct ttcttctcaa
    15361 aaactttggt ataataacga ccaggcatcg accagcgacg actcacattg gtataatcca
    15421 acacagcctg cgtattaccc cggtattcat gatttcccaa gatcgggaac cagtctatca
    15481 tcagttcggg atggctgtaa atcaactcgt agttggtcat ccaaagcgga tcgttaacgc
    15541 tgcgtacacc ttcaaagtgg tgcacgtctc cagctgcaaa cacacactcg ggaccaataa
    15601 catccgccat ttctcccatc agctcggcta tgggcttctg gtcataataa ccgttacgtc
    15661 ccaaatcgtt agccatataa aaattcagtt gtttctccag tcctttccaa tcttgtggag
    15721 tctgggcaca cacattcagg cagatagccg caccaatgac aacaatccat acccatgtca
    15781 atacttcttt catttttcta atcatcatca acgttttcat atacttaatt tttagaaatt
    15841 tatttttaaa cctgcattca ttctcacgcc ataatattct gcctgcatag tacggtcctt
    15901 cgtaccctgg tagtaacgga gcggctggtt cagcagattg ttcgcctcag cataaaaggt
    15961 catcttcacc ttcttgccaa aggtataact ggcgttcaca tccatatagt tcacggcatc
    16021 ataatatctg tcataaaatg tacttgggcc catttcatcg ataaaactgg aggcatagtt
    16081 atagctcagg cgcacattca agcctccttt ttcaaagtaa agagaggcat tcgccgtatg
    16141 ctcgggagac cccggcaaac tcaacccgct ctcgttctca cgtccttcga agttaaagtc
    16201 ctccacacgt gagtgagtat aagtataggt tccatagaaa cccacatact tcaaggccgg
    16261 agcaatgaag ccgaaatcac gctgataaga aaattccaat ccccacagat tagcatttcc
    16321 tgcattcttg ggctgagtga aacgggtata ttctgttcct tggtattcat agttggtcag
    16381 tacctgatct acgatgaaat cgtctatttt cttatagaaa aagcctgcgc tcaccaaacc
    16441 tacactcttg aaataataat cggcactcaa atcgaagttg taagaaatag taggtttcag
    16501 gtcagagtta ccaatcttta tttcattatc gccacggttg atattcacgc taggaaccaa
    16561 agctgaatat ttgggtcggc tcaaggtctg cgtgtaagaa ccgcgtatct tgaaatcatc
    16621 atttacatcc catttcacca aaatagaagg aaggaaattc acataactgt tgacgacgcg
    16681 gccggtcttg gtggtcttat ctgtttcatc atcatagtta cgaccggtat aacgaagaga
    16741 agtgtgctct atgcggagcc ctgccatcaa gtttatatca gaggtaaatt tatggtcaaa
    16801 tcgtacatac ccggaactta cagtttcacg agcctcaaag ttctcagcca attcggcttg
    16861 tacctgttct ttatcgaatt gggaagcatc atttaagttc aatccaccca catattcttt
    16921 actggcaaat gttcctacct gatatttgtc gctcggcata aatttatccg tactctggtc
    16981 taccgtattt ttcaggctgt tggtcatgaa ggcatcctcg tctttcggag tatattcgta
    17041 gaagtctatt tctttttctt tcgttttacg tactactttc gcaccgaact tcagtttggc
    17101 tccattattc aaactggttt tgaaattggc cgaaaatttc atatcctctt ctttgatgtc
    17161 ttcctgttgt tctgtcagtt ctttcaagct gaacttatca ctcagtgtca gggtagaacc
    17221 tgctgtgggt gttgccaacg gctggcgttc atcactcaag tccatatcaa attcctgctt
    17281 tttcagttgg aagtcaagat aacgctcatt agggcgttct tctgtagctt ttgcataact
    17341 ggcattccaa tccatgccga ttgctcccca taagtgttct ccgcccaaag cgaaatccat
    17401 ggtacgctga cgctccagac gggcattgcg attatcagga gtaccagctt tggtttggat
    17461 gcggactgtg ccttttccgt tctcgtccaa atccttgata ttggtacggt aacggttttc
    17521 ccagtcattg cggttgttaa aaataccctt gaaagtcaat ttatggtttt cattgagttc
    17581 gaagtcaaaa gccgccgaat aactttgacg ttcacgggtg acaaagtact gacgcatctg
    17641 ataat
//
