LOCUS       c00110_gnlPro..        13616 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BBKILPPB_110.
ACCESSION   c00110_gnlPro..
VERSION     c00110_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 18:41:00
            Original ID  :: gnl|Prokka|BBKILPPB_110
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13616
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..585)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg110_1"
                     /sec_met_domain="OAD_beta (E-value: 1.2e-70, bitscore:
                     228.4, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFINFLGNNLADFWTYTGFANATVGHIVMILVGLFFIYLAVAK
                     EFEPMLLIPIGFGILIGNIPFNMDAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALEMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMR"
     protocluster    1..13616
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[0:3616]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1..3616
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..13616
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13616
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(587..1021)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 66.7; E-value:
                     4e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg110_2"
                     /sec_met_domain="Biotin_lipoyl (E-value: 1.2e-21, bitscore:
                     66.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNSYKVTIGDIEDNIAHVEVNGTHYKVEMEKQPKTA
                     PKPVVVRPMPNSPAAPTTPVVKPAAPSTGKSGVKSPLPGVILDIKVNVGDTVKRGQTII
                     ILEAMKMENNINADKDGKVTAINVNKGDSVLEGNDLVIIE"
     CDS             complement(1046..1966)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg110_3"
                     /sec_met_domain="OAD_gamma (E-value: 5.3e-15, bitscore:
                     46.2, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLLLLIGLTSCGEQKSNNKLLLNEVLIDNQNNFQD
                     DYGLHSAWIEIFNKSYGSADLAACLLKVSSQPGDTVTYFIPKGDILTLVKPRQHALFWA
                     DGEPNRGTFHTSFKLNPETANWVGLFDSGRKLLDQVVIPAGTLGPNQSYARISDGAADW
                     EVKGGSKDKYVTPSTNNKTLDSNAKMEKFEEHDSVGIGMSISAMSVVFCGLILLFIAFK
                     VVGKVAVNLSKRNAMKAKGIDKVEAKELSQAPGEVYAAISMALHEMQDEVHDVEETVLT
                     ITRVKRSYSPWSSKIYTLRENPNRK"
     CDS             complement(1963..3120)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg110_4"
                     /sec_met_domain="CT_Btheta (E-value: 3.8e-220, bitscore:
                     721.8, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYLFAQDFTVTA
                     GSLSETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGV
                     IPQISGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGAS
                     VHSTKSGVTHFTAKTEEEGLALIRTLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIP
                     DSPNKPYDMYEVISAIVDNGEFLEIQKDYAKNIIIGFARFNGQSVGIVANQPKFLAGVL
                     DSNASRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVP
                     KVTITLRKSYGGSHIVMSCKQXXXXXXXXXXXXXXXXXTLKQERL"
     CDS             complement(3212..3616)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg110_5"
                     /sec_met_domain="Glyoxalase_4 (E-value: 2e-24, bitscore:
                     76.4, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGETKIELLEPTCPESTIAKFIENKGAGVHHVAFAVEDGVANALAEAESKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             complement(3790..4788)
                     /locus_tag="ctg110_6"
                     /transl_table=11
                     /translation="MPLKLTTYYRGKDIPDLPGTNTFHSKELFQIYESTPGYTPLLIVA
                     TEEGRPVARLLAAIRKTKKWLPSSLVKQCVVYGAGEFLDTSLPASKEKEEEIFGEMLEH
                     LTQEASRTCILIEFRNLDNSMFGYRFFRKNDFFPVNWLRVRNSLHSTQKAEDRFSPSRI
                     RQIRKGLKNGAKVVEAHTVEEIKEFSRMLHKVYSSRIRRYFPANDFFRHMNSMLIRGKQ
                     AKIFIVKYKEKIIGGSVCIYSGENAFIWFSGGMRKTYALQSPGILAVWKALEDAHERGF
                     RHMEFMDVGLPFRKHGYRDFVLRFGGKQSSTRRWFRISWPWLNNLLVKFYV"
     CDS             5037..8231
                     /locus_tag="ctg110_7"
                     /transl_table=11
                     /translation="MRENAFVEAWKTQHRRVSMILGLTLLCAPSAISVYAENGVNDITV
                     QAVMQTKTVKGTVLDENGEPLIGVSIVVKGTSTGTITDFDGKFSINLPAGSKELVVSYI
                     GYKEQAIIVSGNAPLNIKMVPDTQALDEVVVIGYGTVKKRDLTGAVASVKSEDITMNPG
                     VNPMDALQGKIAGLDITNSSGQAGSSPTVQLRGTRSLQLDEDGNISSDAFKPTYIIDGM
                     PGDIATLNPNDIESIEVLKDASSTAIYGSSGANGVIIVTTKGSKSGKPVINFNAYAGTT
                     LGAKVPKMRTGDSYINYIKDSYKPVGTTNEEEIFGERYDAIKNSQWVNWGDEVLHSGLK
                     QNYSISVAGGTEKTKAYFSLNYTDEKSMYENDDYKVYSTRVRIDQEINKWMNAGINVQA
                     SFSNKNSRNAVLERALFATPLGTPYNEDGSITEFPIPGSSSDPNPLADEQDGVYKNNTK
                     AGRAYVDAYLEWKPVKGLSVKSQLGGSYSQSRAGKFMGEGSYNVLKGSTVAYGEATNKT
                     GYNYKWENIVTYHNTFNKDHDLTVTGVTSWNYNQSEEYYVYGENPATNDMLWYALQNAD
                     NKKLNSKYLMSKGMGFIGRVNYSYKGKYLFSASSRYEADSRLSKDNRWNLFPAVSVGWR
                     ISDEAFMAGTKSWLDNLKLRVGYGVAGTTAGIAEYSSMASLENVTTSLGGMTVPSAKFT
                     EYITNRNLTWEKTHDLNIGIDASFLNNRIDLTVDLYRTKTTDVILSQALPTSIMGNYTG
                     STTYKMNKNAAETENRGIELALNTRNIVKKDFTWSSTVTFTANKEKIKSLIEGQDMMFN
                     AKKGDMVFKVGEGVGSFYRYKVLGIWQYSEKETAALFGCEPGDIKLDLPSVKKDGNGYY
                     YMNPEGERVDITAENPYGVRADYDRQVIGRNTPDWTLGFKNNFRYKDFDLSVFLYARWG
                     QMMNYGSVIGKYSPNPDYNIPTYFTYYDKTIEADQDVLFYAIDKSKDRSAYEGYDSMYY
                     VDGSFFKLKNVTLGYTLPGKLTKRFGISNLRVYATMTNLFTYSPNKYVKNYDPEMNGSI
                     NFPLSRDCIFGLNLTF"
     CDS             8243..10198
                     /locus_tag="ctg110_8"
                     /transl_table=11
                     /translation="MKKIYSLVLLVAGVFSWGSCSLDEVNPNNSGQFSDGSYTLETYKA
                     FTNSCYTALINNIYQSSDYLVCTEAGTDIWEEPKSGSSYQRYHSYNGMKTDDSYYYKVW
                     QYSYLCINSCNIVIDGAENVTGDETEINECVAQARCLRAYYYMNLVEQFGNVDLQLKAA
                     DSENISFDAHRSTVPEIYAAIIEDLKFAVENLPVSFSDYYSRVTKKSAMGLLARAYING
                     AGYDLKDTDGVSFLEKAYDTATTMINNKAIYEWYMHPAFADVFNENNNRNNEEALFIAA
                     GAERNSDAYTNGNYSQSEMFRHFLPSLGTYTDLGLVDKTSNFVYGRPNSNIFLPSKYLM
                     DCFAADMNDSRFRYSFISAYSSYSIPAWGATYEYGGSACAKEITSTLATKFGIPASNIG
                     KKVYPHFNLESNSTADANYCQLAIWNADGTAKTTQDKTDGNILHPAMPLDPAEAHQYAV
                     YCSLKTLTEEEKAQYPGLVLNVFDLYDENGTARATYDKPSAASALWLSIYPALSKFNMP
                     GNKFVGRDVQRKTVDVMIMRMAEVYLIAAEASVRLNKGDAAKYINVLRTRAGAGTVSES
                     QVDLNYVFDEYARELCGECGRWYLLKRNAAFETRLAAYNKRAAEHFKKEFYLRPIPTKY
                     LDAINNLAEFGQNAGY"
     CDS             10385..10927
                     /locus_tag="ctg110_9"
                     /transl_table=11
                     /translation="MIEEMLAYNREFVKNEGYKEYITNKYPDKKIAILSCMDTRLTALL
                     PAALGIKNGDVKMIKNAGGVISHPFGSVIRSLLVAIFELGVEEIMVIAHSDCGACHMHS
                     EEMLEKMKARGINADYIHMMSFCGVDFHSWLDGFEDTEKSVRGTVDFIVHHPLIPSDVK
                     VHGFIIDSTTGELTRIV"
     CDS             complement(11041..11226)
                     /locus_tag="ctg110_10"
                     /transl_table=11
                     /translation="MKKRITQDDYIKANRKASREAEIKEHGHPVCYKRVHESKKVYNRR
                     KIKAADKKLPYFFHLG"
     CDS             11326..11862
                     /locus_tag="ctg110_11"
                     /transl_table=11
                     /translation="MENFSELIKNRRSMRKFTDEELTQDEVVALMKAALMSPSSKRSNS
                     WQFVVVDDKEKLKELSHCKEQASSFIADAALAIVVMADPLASDVWIEDASIASIMIQLQ
                     AEDLGLGSCWVQVRERFTATGMPSDEFVHGILDIPLQLQILSVIAIGHKGMERKPFNEE
                     HLQWEKIHINKFGGK"
     CDS             11865..12200
                     /locus_tag="ctg110_12"
                     /transl_table=11
                     /translation="MGAVKANNNKDTYKATAVAFIVIGTLFLINKLLPFASIGLPWVMN
                     KDNLLLYASISFLIFKRDKSVGFVLLGLWLVMNIGLVMSLLGSLSGYLLPLALLIIGII
                     LFWVSKR"
     CDS             12208..13002
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg110_13"
                     /sec_met_domain="F420_oxidored (E-value: 6.9e-14, bitscore:
                     42.7, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRSIEDTPVVFLGAGNLATNLAKALYRKGFRIMQVYSRTEESAR
                     TLANEVEAEYITDLKDVSNEARLYIISLKDAAFVELLPQITDGKQHALLVHTAGSIPMN
                     IWEGHVERYGVFYPMQTFSKQREVDFREVPFFIEAKRPEDTELLKAVAGTLSDKVYEAD
                     SEQRRSLHLAAVFTCNFTNHMYALAAELLEKYHLPFDVMLPLIDETARKVHELAPRDAQ
                     TGPAVRYDENVMNKHLSMLADSQALQEIYKLMSKSIHEHHQL"
     CDS             12983..13504
                     /locus_tag="ctg110_14"
                     /transl_table=11
                     /translation="MSTINYDLSRIKALAFDVDGVLSSTTVPLHPSGEPMRTVNIKDGY
                     AIQLAVKKGLHIAIITGGRTEAVRIRFAALGVKDLYMGSAVKIHDYRDFRDKYGLSDDE
                     ILYMGDDVPDIEVMRECGLPCCPKDAVPEVKSVAKYISYADGGRGCGRDVVEQVLKAHG
                     KWMAEDAFGW"
ORIGIN
        1 acgcatgata ggcggctgta tcaccggaac taacgccata taggagtagg cggataccgc
       61 aatggctccc attaagttag gtgccagctt ggacgaaagg aagatagctg tcggaccatc
      121 tgctccaccg atgataccga tagcaccggc ctgcatcggg tcaaatccca tttccaatgc
      181 gatcatgtat gcaccgaaga taccaaactg ggcagctgca ccaatcagca tcagcttcgg
      241 attggagatc agcgccgaga agtctgtcat ggcaccgata cctaagaaga tgagcggtgg
      301 ataccagccg gacgttactc cctgatacaa tatgttcaat acagaacctt cttcatatat
      361 accgactttt agtccggcgt ccatattgaa gggtatatta ccgatcagga taccgaatcc
      421 gataggaatt aacaacatcg gctcgaactc tttggctaca gccaaataga tgaagaacaa
      481 gccaacgagg atcatcacga tatgaccaac tgtcgcgttg gcaaatcccg tgtaggtcca
      541 gaagtcggca aggttatttc ctaaaaagtt aataaaatct cccatattat tcaataatta
      601 cgaggtcatt accttcaaga acagaatctc ccttgttgac attgatagca gtcactttac
      661 cgtctttgtc tgcattgata ttgttttcca tcttcatggc ttccaatata atgatagtct
      721 gtcctctttt cactgtatca cctacattta ctttgatgtc aaggataacg cctggtagcg
      781 gggacttaac gcctgatttg cctgtagaag gagcagccgg ttttactacc ggtgtggtag
      841 gagcagccgg tgagttaggc ataggacgta ctactaccgg tttgggagca gttttcggtt
      901 gtttctccat ttctactttg tagtgcgtac cgttcacttc tacatgagcg atattatctt
      961 caatatctcc gatggttact ttgtatgagt taccgttgat tttatattta tattctttca
     1021 tcgttttatc tttttaggga atgatttact ttctgttagg attttcacgc aaggtgtaaa
     1081 tcttcgaact ccacggtgaa taactgcgtt tcacacgagt gatggtcagc accgtttctt
     1141 ctacgtcatg tacctcatcc tgcatttcgt gtaatgccat tgaaatagca gcataaactt
     1201 cacccggagc ctgtgaaagc tctttcgctt cgactttatc gatgccttta gccttcatcg
     1261 cattgcgttt gctcaggttg acagcaactt tacctaccac cttgaaggca atgaagagaa
     1321 gaatcaatcc gcagaatact acgctcatgg ctgaaataga cataccgata ccgactgagt
     1381 catgttcttc gaacttttcc atcttggcat tactgtcaag ggttttgttg ttcgtgctcg
     1441 gggttacgta tttgtctttg cttccgcctt ttacttccca gtctgctgct ccgtcgctta
     1501 tgcgtgcata agactggttg ggacctaaag ttcctgctgg tatgacaact tgatcaagta
     1561 gctttctgcc tgaatcaaaa agaccgaccc aattggctgt ttcagggttc agtttgaagc
     1621 tggtatggaa ggtaccacga ttaggttcgc cgtctgccca aaataacgca tgttggcgtg
     1681 gctttactaa tgtaagtatg tcacctttcg ggataaaata ggttactgta tcgcccggct
     1741 ggctgcttac tttcaataaa caagctgcta agtctgcgct accgtatgat ttgttgaata
     1801 tttcaatcca tgcactgtgc aagccgtagt catcctgaaa gttgttttga ttgtctatca
     1861 agacttcatt cagcaatagc ttattgttcg acttttgctc tccgcaggaa gtcaatccaa
     1921 tcagcaacag cagagaaagg aatattccga ttttggtttt gttcataatc gttcttgttt
     1981 taatgtgnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnttg
     2041 cttacagctc atcacgatgt gagaaccacc gtaagattta cgcaatgtga ttgttacttt
     2101 aggtacggta gcttcaccgt aagcatacag cagtttggca ccatgaagga taacgccatt
     2161 gtattcctgg cctgttcccg gaaggaatcc cggtacgtct accaacgaca cgatagggat
     2221 attgaaagca tcgcagaaac gaacgaaacg tgcgcctttg cgagatgcgt tgctgtcgag
     2281 tacaccggca aggaatttag gctgattggc tacaatacct acagactgac cgttgaaacg
     2341 ggcaaaaccg ataatgatat tcttggcata gtctttctgg atttccagga attcgccgtt
     2401 gtccacgata gcgctgataa cctcgtacat atcatacggt ttgttggggc tgtcggggat
     2461 aatatcgttc agagaatctt ccagacggtc gatcggatct gtgcaatcca cgtatggagc
     2521 ttcttcgagg ttgttttgag gaatatagct cagaagtgtg cggatcaatg ccagaccttc
     2581 ttcttctgtt ttggcagtga aatgagtaac acccgatttg gtagagtgaa cgcttgctcc
     2641 gccgaggttt tcctggctta cgtcttcacc ggttacagtt ttcactactt tcggacctgt
     2701 aaggaacata taagaagtac cttccatcat cagtgtgaag tctgtcagtg ccggagaata
     2761 aacagcaccg ccggcacaag gcccgaagat accggaaatc tgcggaatga cacccgaagc
     2821 gaggatattg cgctggaaga tttctgcgta acctgccaaa gcgttaatac cttcttggat
     2881 acgtgcacca cccgagtcat tgataccgat acaaggagca cccatcttca ttgcctgatc
     2941 cataatctta cagatcttca gtgacattgt ttccgacagt gaacctgcag taacggtaaa
     3001 gtcctgtgca aaaagatata cgagacgacc ttcgatagta ccgcaaccgg ttactacacc
     3061 atcacccgga tagtgctttt tctccatgcc gaagttcgtg catctgtgct caacgaacat
     3121 gtccatttct nnnnnnnnnn gcgttcaata agctctttaa ttttttcaag ttgattactc
     3181 atgagttctt gttgtttttt agagtttatg attagtgttc gcagagttct gtcagcacac
     3241 ccagtgttga tttcgggtga aggaaagcga tgttcagacc ttcggcacct ttgcggggag
     3301 ccttgtcaat cagacggatt tctttgcttt ctgcttctgc caaagcatta gctacgccat
     3361 cttctacggc aaatgctacg tgatgaacac ctgcaccttt gttttcaata aatttagcaa
     3421 tggtgctttc ggggcaagtc ggctccaaca attcgatttt tgtttcacct acctttaaaa
     3481 aagcggttct tactttttga tcttctactg tttcgatgtt gtaacatttc agacccaata
     3541 cgttttcgta gtaaggaagg gcttcttcga tgctttttac agcaatgccc agatgctcaa
     3601 tgtgtgaaat cttcataact atattttttt atatggttta attatgtgct tatatggcat
     3661 aaaacagcac aaagaaagac atttcttgtc taataaagaa atatttctgc atttaattat
     3721 tggggaataa agcataaaaa atgctccgga tgggtgacaa agacgggttt tgtaatcttg
     3781 agattacatt tagacataaa acttgaccag aagattattc agccatggcc agctgatacg
     3841 gaaccagcgg cgggtactgc tttgtttgcc tccgaaacgg agtacgaaat cacgataacc
     3901 atgtttgcgg aagggaagtc ctacatccat gaactccatg tgacggaatc cccgttcatg
     3961 ggcatcttca agtgctttcc atactgccag tatgccgggt gactgcagtg catacgtctt
     4021 tcgcattcct cctgaaaacc agataaaagc attttcgccg gaatagatgc agacggagcc
     4081 gccgataatc ttttccttgt attttacgat gaatattttt gcctgttttc ctctgataag
     4141 catgctgttc atgtggcgga aaaagtcatt ggcagggaaa tatctccgta ttcgtgaaga
     4201 ataaactttg tgcagcatcc gcgagaattc cttaatctct tccaccgtat gggcttctac
     4261 tactttggct ccgtttttga gtcctttccg gatctgacgg atacgtgacg ggctgaaacg
     4321 gtcttccgct ttctgcgtac tatgcagaga gttacggaca cgcagccagt tgaccggaaa
     4381 aaagtcgttc tttcggaaga aacggtaacc gaacatggaa ttatccagat tgcggaattc
     4441 aataagaatg caggtgcgtg atgcttcttg tgtgagatgc tccagcattt caccgaaaat
     4501 ttcttcctcc ttctctttac ttgccggtag agaagtgtcc agaaattcac ctgcaccata
     4561 taccacacat tgtttgacaa gagaggaggg aagccacttt ttggtcttgc gtatggcggc
     4621 aagcaggcgt gctacaggtc tgccttcttc tgttgccact atcagtagcg gggtatatcc
     4681 cggagtcgat tcatagatct gaaacaactc cttggaatga aaagtattgg ttcccggtaa
     4741 atcaggaatg tcttttccgc gataatatgt tgttagttta agtggcatcc aaatacaaat
     4801 ttacactttt tattcttcat tcaacaataa aaaagagaat ttgttggctt agcctaaaat
     4861 ttgtcttttt atcctttgca tatatttgag gaaaaaaagg cttggaaaag cgaatttttg
     4921 tattattgtc gtcctttgtg agtacagaag taaaatggaa acgtctatgt aaaagattat
     4981 gctaattgta ttttactaaa caaaggaaaa ttaatattaa ctttaaatta aaacgaatga
     5041 gagagaatgc atttgttgaa gcgtggaaga cacagcatag acgcgtttcc atgattttag
     5101 ggctgacttt attgtgtgcc ccttctgcca tatctgttta tgcagaaaat ggtgtgaatg
     5161 atattactgt gcaagccgtc atgcagacaa agacagtgaa aggaactgtt ttagatgaaa
     5221 atggagaacc gttgatcggt gtctctattg tggtgaaagg tacaagtaca ggtacgataa
     5281 ctgattttga cggtaagttc tccattaatc ttccggccgg aagtaaagaa ctggttgttt
     5341 cttatatcgg atataaagaa caggctatta ttgtgagcgg aaatgccccg ctgaatataa
     5401 agatggttcc ggatacacag gctttggatg aggtagtggt catcggttac ggtacggtaa
     5461 agaaacgtga tttgacaggt gcggttgctt ctgtgaaatc agaggatatc accatgaatc
     5521 cgggcgtgaa tccgatggat gcgctgcaag gtaaaattgc aggtctggat atcactaatt
     5581 cttcaggtca ggcaggttcg tcaccgacag ttcagttgcg tggtacccgc tctttgcagt
     5641 tggatgagga tggtaatatt tcttccgatg catttaagcc gacttatatt atcgatggta
     5701 tgccgggtga tattgctacc ttgaatccca atgatattga atctatcgaa gtactgaaag
     5761 atgcatcttc tacggctatc tacggttcaa gtggtgcgaa tggtgttatt atcgtgacta
     5821 cgaaaggatc caagagtgga aaaccggtca tcaatttcaa tgcttatgcc ggaacgactt
     5881 taggagctaa agttcctaag atgcgtacgg gtgactcata cattaattat ataaaagatt
     5941 cttataagcc tgtcggtact actaatgagg aggaaatttt cggtgaaaga tacgatgcca
     6001 tcaaaaacag ccaatgggta aactggggag atgaagtatt acactcaggt ttgaagcaga
     6061 attatagtat ttccgttgcc ggaggtactg agaagacgaa agcctatttc tcgttgaact
     6121 atactgatga gaagagtatg tatgagaatg atgactataa agtgtactct acccgtgtcc
     6181 gtatagatca ggaaatcaat aaatggatga atgccggtat taatgttcag gcatctttct
     6241 ccaacaagaa ttcacgtaat gccgttttgg aaagagcatt gtttgccacc ccgttaggta
     6301 ctccttataa tgaagacggc tctatcacgg aattcccgat tccaggttca tcatcagacc
     6361 cgaatccgtt agcagacgaa caggatggag tatataagaa taatactaaa gcaggaaggg
     6421 cttatgttga cgcttatctg gaatggaaac cggtaaaagg attgtctgtc aagtcacagc
     6481 ttggaggcag ttattctcaa tctcgtgccg gtaaatttat gggagaaggc tcttataatg
     6541 tgttgaaagg cagtacggtg gcatatggcg aagctaccaa taagacggga tataattaca
     6601 aatgggaaaa catagtaact tatcacaata catttaataa ggatcatgac ctgacggtta
     6661 caggggttac ttcctggaat tacaatcaga gtgaagaata ttatgtctat ggtgaaaacc
     6721 cggcgaccaa tgatatgttg tggtatgcat tgcagaatgc tgataataag aaactgaaca
     6781 gcaaatatct gatgtcgaag gggatgggct ttatcggtcg tgtcaactac tcatacaaag
     6841 gtaaatacct gttctctgct tccagtcgtt atgaagcgga ttcccgtttg tcgaaagaca
     6901 atagatggaa tttattcccg gcagtttctg taggctggag aatctcggat gaagcattta
     6961 tggctggtac aaaaagctgg ttggataact tgaaactgcg tgtaggctat ggtgttgccg
     7021 gaactactgc cggtattgct gaatacagtt ctatggcatc tttggaaaat gtgacaactt
     7081 ctttgggagg aatgactgtt ccgtcagcca agtttacgga gtatatcact aaccgtaatc
     7141 tgacatggga aaagactcat gacttgaata ttggtattga tgccagcttc ctcaataatc
     7201 gtattgatct gacggtggat ttgtatcgga caaaaacaac ggatgtaatt ctttcgcagg
     7261 cattgccgac atctattatg ggtaattaca caggtagcac tacttataaa atgaacaaga
     7321 atgctgctga aacagaaaat cgcggtattg aacttgctct taatacccgt aatattgtga
     7381 agaaagattt tacttggagc tcaacagtga catttaccgc caacaaagaa aaaattaaat
     7441 ctttgatcga agggcaggat atgatgttca atgcaaaaaa gggtgatatg gtgttcaaag
     7501 tcggcgaagg agtcggttct ttctatagat ataaagtgtt gggtatctgg caatatagcg
     7561 aaaaggaaac tgctgctttg ttcggatgcg aaccgggcga tattaagctg gatttaccta
     7621 gtgtgaagaa ggacggaaat ggttattatt atatgaatcc tgaaggagag cgcgttgata
     7681 ttacggcaga aaatccttat ggtgtacgtg cggattatga tcgtcaggta ataggtcgta
     7741 atactccgga ctggacattg ggctttaaga ataatttcag atacaaagat tttgatttgt
     7801 ctgtcttcct ttatgcacgt tgggggcaaa tgatgaacta tggtagtgtg ataggtaaat
     7861 attcgcctaa cccggattac aatattccta cttattttac ttactatgac aagacgatcg
     7921 aagcagatca ggatgtcttg ttctatgcta tcgataaatc caaggataga agtgcttatg
     7981 aaggatatga ttcgatgtat tatgtggatg gatcattctt taaacttaaa aacgtaacat
     8041 tgggttatac gttacccggt aaacttacaa aacgttttgg tatcagtaat ctgagagttt
     8101 atgcgacaat gaccaacctg tttacttatt cgccaaacaa atatgtgaag aattacgatc
     8161 cggaaatgaa cggaagcatc aacttcccat tgtctcgtga ttgcatattt ggtcttaatt
     8221 taactttcta aaaaatagca atatgaaaaa gatatatagt ttagttctac ttgttgccgg
     8281 tgttttttct tggggctctt gcagtcttga tgaagtgaac cccaacaact cgggtcagtt
     8341 ctccgatggt tcttatacat tggaaactta taaggcattc accaactcgt gctatacagc
     8401 tttgatcaac aacatctatc agagtagtga ctatctggtt tgtacggaag cgggtactga
     8461 tatttgggaa gaacctaaat cgggttccag ctatcagcgt tatcatagtt ataacggtat
     8521 gaaaaccgat gatagctatt attataaagt gtggcaatat tcttatctgt gtatcaacag
     8581 ctgtaatatt gtgattgacg gagctgagaa tgtgacaggg gatgagactg aaattaatga
     8641 atgtgtggca caggccagat gtctgcgtgc ttactattat atgaatctgg tggagcagtt
     8701 tggaaatgtc gatttgcagt tgaaggctgc cgatagcgag aatatttctt ttgatgctca
     8761 ccgttctacc gttcccgaaa tttatgctgc cattatcgaa gacctgaagt ttgccgtaga
     8821 gaatctgcct gtaagtttca gtgattacta tagccgcgtt acaaagaaat cggcgatggg
     8881 attattggca cgtgcatata ttaatggtgc cggttatgat ctgaaagata ccgatggtgt
     8941 cagcttcctg gaaaaagcct atgatacggc gacaaccatg attaataata aagcgattta
     9001 tgagtggtat atgcatcccg cttttgccga tgtattcaac gaaaataata atcgtaacaa
     9061 tgaagaagct ctgttcatag ctgcgggtgc cgaaagaaat tcggacgctt acaccaatgg
     9121 taactactca caaagtgaaa tgttccgtca cttcttacct tcgttgggaa catatacgga
     9181 cctgggtttg gtcgacaaga cttcaaactt cgtatacggt cgtccgaaca gtaatatctt
     9241 cctgccatcc aaatatctga tggactgttt tgctgctgat atgaacgact ctcgttttcg
     9301 ttattcattt atctcagctt actcgtctta ttcaataccg gcatgggggg cgacttatga
     9361 atatggaggt tcagcgtgtg ccaaagaaat cacaagcaca cttgctacta aatttggtat
     9421 tcccgcatct aatataggta agaaagttta tcctcatttt aacttggaat ccaatagtac
     9481 agccgatgct aattactgcc agctggctat ctggaatgca gatggaacag cgaagactac
     9541 tcaggataaa acagatggta atattcttca tcctgctatg cctttagatc cggcagaagc
     9601 tcatcaatat gccgtttatt gttctttgaa gacgctgaca gaagaggaaa aagctcaata
     9661 tccggggttg gttcttaatg ttttcgatct ttacgatgag aatggaacag ccagggctac
     9721 ctatgacaag cctagtgctg ccagtgcttt gtggttatct atttatccgg ctctttctaa
     9781 attcaatatg ccgggtaata agtttgtcgg cagagacgtt cagagaaaaa ctgtggatgt
     9841 gatgatcatg cgtatggcag aagtttacct gattgctgct gaagcatcgg tacgcttgaa
     9901 caagggagat gctgccaaat atattaatgt actccgtacg cgtgccggtg ccggtacggt
     9961 cagtgagtcg caagtggatc tgaattatgt tttcgatgaa tatgcccgtg aactttgtgg
    10021 cgaatgtggc cgctggtatt tgctgaaacg taatgctgct tttgagactc gtttggctgc
    10081 ttataataag cgtgctgccg agcactttaa gaaagaattc tatttgcgtc ctattcctac
    10141 gaaatatctg gatgcgatca ataatctggc agaattcgga caaaacgccg gttattaatc
    10201 agttaattaa taatcaagca taattaatag gagccgggca ggagatttct cttgtccggc
    10261 tctttgtttc cagacctgta tcctgcgtaa aagtttaaaa aggatttccg gtatattttc
    10321 attgtttcct gatacagcct tttattattt tctttatttt tgtgtgtcca aacaaaatag
    10381 tgctatgata gaagaaatgc ttgcttataa cagagagttc gttaagaacg agggatataa
    10441 agaatatata acgaataaat atcccgataa aaagattgct atcttatcct gtatggatac
    10501 acgcctgaca gctttactcc cggccgcact aggcattaag aacggagacg ttaaaatgat
    10561 caagaatgca ggaggcgtca tttcccatcc tttcggtagt gtgattcgca gtctgcttgt
    10621 cgctatcttc gagttaggtg tggaggaaat aatggtgatt gcccattctg attgtggagc
    10681 ctgccatatg cacagtgaag aaatgcttga gaagatgaag gcacggggta ttaatgccga
    10741 ttatattcat atgatgagtt tttgtggagt cgattttcat tcttggctag atggctttga
    10801 agatacggag aagtcggtaa ggggaacggt cgattttata gttcatcatc ctttgattcc
    10861 gtcggacgtg aaagtgcacg ggtttatcat agactccact actggagaac tgacgcgaat
    10921 tgtataggaa atcgcccttt ctgcctatca ggaactgcat aaaacatggt gtcactatcg
    10981 caacaggata gtgtcactat cactgtctca tggtgtcact atgtcattgg gataccgaca
    11041 ctatcccaaa tgaaaaaaat aaggcagctt tttatcggct gcctttatct ttctacggtt
    11101 atatactttc tttgactcat gcactcgttt gtaacaaacg gggtgtccgt gctctttgat
    11161 ttctgcctca cggctggctt tacgattcgc tttgatgtaa tcgtcttgtg taattcgttt
    11221 tttcataatg aatatatttc tcagtgcaaa gatacaattt catttcttat tacgatcggt
    11281 ttgcgctatc tttgcataca taaatcaaat gaaaacggaa ataatatgga aaatttcagt
    11341 gaactgataa agaatcgccg cagtatgcgc aaatttacgg atgaggagtt aacacaggat
    11401 gaggttgtgg cactgatgaa agctgcctta atgtctccca gttccaaacg tagtaatagc
    11461 tggcagtttg tggtagtcga tgataaagaa aagttgaaag aactgtctca ctgcaaagaa
    11521 caggcttctt ctttcattgc agacgctgct ttggcgattg ttgtgatggc cgatccgttg
    11581 gcaagcgatg tgtggattga agatgcttct attgcttcca tcatgataca gttgcaggcg
    11641 gaagatttgg ggctgggaag ctgttgggta caggttcgcg aacgtttcac tgcaaccgga
    11701 atgccgtctg acgagtttgt tcatggaatt ttggatattc ctttgcaact gcagattctt
    11761 tccgtgattg ccatcggaca taagggaatg gaacgtaagc ctttcaacga agaacacctt
    11821 cagtgggaga aaattcatat taataagttc ggaggaaaat aacgatggga gctgtcaaag
    11881 caaataataa taaagatact tataaggcta ctgccgtcgc ttttattgtc atcggaactc
    11941 ttttcctgat aaataaactg ctcccctttg cttctatagg tttgccttgg gtgatgaata
    12001 aggacaattt gttgttgtat gcctctatca gttttcttat tttcaagcgt gacaagtcgg
    12061 tcggctttgt gctgttggga ctgtggctgg taatgaatat cggtctggta atgtcattgc
    12121 tcggttcctt gtccggttat ctgttgccat tggcactgtt gatcatcgga attattttat
    12181 tttgggtttc aaaacgttaa agaaacaatg aaaagaagta ttgaagatac gcccgttgtg
    12241 tttctcggtg ccggaaatct ggcaactaat ctggcgaaag cgctttaccg gaaaggattc
    12301 cgtatcatgc aggtgtacag ccgaacggaa gaatcggctc gtacgttagc caatgaagtg
    12361 gaagcggaat atatcactga tttaaaagac gtatcgaatg aagcgagatt atatattatt
    12421 tcattgaaag atgccgcttt cgtcgaactg ttgcctcaga tcactgatgg gaagcagcat
    12481 gcgctgttgg tgcatacggc aggcagcatc ccgatgaata tttgggaagg tcatgtggaa
    12541 cgctacggag tattttatcc gatgcagacg ttcagcaaac aacgtgaagt tgattttcgg
    12601 gaagtacctt tctttattga agcaaaaaga ccggaagata ccgagctgct gaaagcggtt
    12661 gccggtacac tctctgataa ggtgtacgaa gccgattcgg agcaacgcag aagtcttcat
    12721 ctggcagctg tctttacctg taactttacc aaccatatgt atgctcttgc cgccgaattg
    12781 ctggaaaaat atcatttgcc atttgatgtc atgcttcccc tgattgacga aacggcacgc
    12841 aaagtgcatg aactcgctcc tcgtgatgcg cagaccggac cggctgtacg ctatgacgag
    12901 aatgtgatga ataagcatct ttctatgctg gcagacagtc aggcattgca ggaaatttat
    12961 aaattaatga gtaaaagtat ccatgagcac catcaattat gatctatccc gcatcaaagc
    13021 actggctttt gatgttgacg gagtattgag ttcgacaaca gtcccgttgc atccttccgg
    13081 agaaccgatg cgtacagtga atatcaaaga cggttatgcc attcagctgg cggtaaagaa
    13141 aggacttcat attgctatca ttaccggtgg acggacagaa gcggtacgta tccggtttgc
    13201 agcattgggt gtgaaggatc tgtatatggg gtctgcagtg aaaattcatg attaccgtga
    13261 tttccgcgat aaatacggtc tgtctgatga cgaaattctg tatatgggcg atgatgtgcc
    13321 tgatatagaa gtgatgcgtg agtgcgggtt gccttgttgt cccaaagatg cagttccgga
    13381 agttaagtcg gttgcgaagt atatatctta tgccgatggc ggtcgtggct gtggacgtga
    13441 tgtggtggaa caagtattga aagctcatgg caagtggatg gcggaagatg ctttcggctg
    13501 gtgagttgta aatcactaaa tgataaataa aactatgctt ggaaatttag ataaatatca
    13561 gattatatta gcctccaatt ctccccgccg gaaagaactg atgtcaggct tgggag
//
