LOCUS       c00125_gnlPro..         3910 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HPMLHGED_125.
ACCESSION   c00125_gnlPro..
VERSION     c00125_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 23:03:00
            Original ID  :: gnl|Prokka|HPMLHGED_125
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 3910
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..3910
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2:3910]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3..3910
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..3910
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..3910
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             3..1532
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg125_1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.8e-47, bitscore:
                     148.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="AAHAAQGYARVSGKVGVCLVTSGPGATNTITGIADAMIDSTPIVV
                     IAGQVGTGFLGTDAFQEVDLVGITQPIAKWSYQIRRAEDVAWAIARAFYIASSGRPGPV
                     VLDFAKNAQVEKTKYEPTKQEFIRSYVPVPDTDEESVKAAAELINNAERPLVLVGQGVE
                     LGSAQEELRIFIEKADMPAGCTLLGLSALPTDHPLNKGMLGMHGNLGPNINTNKCDVLI
                     AVGMRFDDRVTGNLATYAKQAKVIHFDIDPAEVNKNVKVDIAVLGDCKKTLAAVTGLLK
                     KNRHTEWVDSFKEYEAVEEEKVIRPELHPATDSLSMGEVVRAVSEATRHEAILVTDVGQ
                     NQMISARYFKYTRERSIVTSGGLGTMGFGLPAAIGATFGRPDRIVCVFMGDGGLQMNIQ
                     ELGTIMEQKAPVKIICLNNNYLGNVRQWQAMFFNRRYSFTPMLNPDYMKIASAYDIPSK
                     RVFSREELKAAIDEMLSTDGAFLLEACVVEEGNVLPMTPPGGSVNQMLLEC"
     CDS             1551..2114
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg125_2"
                     /sec_met_domain="ALS_ss_C (E-value: 2.2e-20, bitscore:
                     60.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDKTLYTIIVHSENIAGLLNQVTAVFTRRQINIESLNVSASSIK
                     GVHKYTITAWTDKDTIEKVVKQIEKKIDVIQAHYFTEDEIYFHEIALYKVSTPAFQETP
                     EASKVIRRYNARIVEVNPVFSIVEKNGMSEEITSLYEELRALKCVLQFVRSGRVAITTS
                     CFERVNEFLDGQEAKYKQSKKEQE"
     CDS             2114..2857
                     /locus_tag="ctg125_3"
                     /transl_table=11
                     /translation="MSEENKIGTYQFVAEPFHVDFNGRLTMGVLGNHLLNCAGFHASDR
                     GFGIATLNEDNYTWVLSRLAIELDEMPYQYEKFSVQTWVENVYRLFTDRNFAVIDKDGK
                     KIGYARSVWAMINLNTRKPADLLALHGGSIVDYICDEPCPIEKPSRIKVTSNQPVATLT
                     AKYSDIDINGHVNSIRYIEHILDLFPIELYQTKRIRRFEMAYVAESYFGDELSFFCDEV
                     SENEFHVEVKKNGSEVVCRSKVIFE"
     CDS             2921..3910
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg125_4"
                     /sec_met_domain="IlvN (E-value: 1.1e-47, bitscore: 149.7,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 9.8e-37, bitscore: 114.6,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGTVENVVIRDEFPLEKAREVLKNETIAVIGYGVQGPGQ
                     ALNLRDNGFNVIVGQRQGKTYDKAVADGWVPGETLFGIEEACEKGTIIMCLLSDAAVMS
                     VWPTIKPYLTAGKALYFSHGFAITWSDRTGVVPPADIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAIYQDATGNAMDRTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMG
                     PFHDAIKPVVEKLYHSVKTGNEAQISIDSNSKPDYREKLEEELKALRES"
ORIGIN
        1 gagctgccca tgcggcacaa ggctacgccc gtgtatcggg taaagtcggt gtttgcttgg
       61 tgacaagcgg ccccggagca accaatacga tcacaggtat tgcagatgca atgatagaca
      121 gtacgcctat cgttgtcatt gcaggacagg tgggaacagg ctttcttgga acagacgctt
      181 ttcaggaagt cgatctcgta ggtatcactc agccaatcgc taaatggagc tatcagattc
      241 gccgtgccga agacgtagcc tgggcgatag cacgtgcttt ctacattgcc agtagtggtc
      301 gtcccggtcc ggtggtactc gactttgcca agaatgcgca ggttgaaaaa acgaaatacg
      361 agccgacaaa gcaggagttt atccgcagct atgttccggt tcccgataca gacgaagaat
      421 cggtaaaggc tgccgccgaa ctgatcaata acgccgaacg cccgcttgtc ttggtaggac
      481 agggagtgga actgggaagc gctcaggaag aactgcgtat ctttatcgaa aaggcggata
      541 tgcccgcagg ttgtaccttg ctcggacttt ccgcattgcc taccgatcat ccgttgaata
      601 aaggaatgct gggtatgcac ggaaatctgg gaccgaatat caatactaac aaatgtgatg
      661 tactgattgc tgtcggtatg cgtttcgacg accgtgtgac cggtaatctg gctacttacg
      721 ccaaacaagc gaaagtgatc cattttgaca ttgatccggc ggaagtaaat aagaatgtaa
      781 aggtagatat tgccgttttg ggcgactgca aaaagacgct ggctgctgtg accggactgt
      841 tgaaaaagaa ccggcacacc gagtgggtcg atagtttcaa ggaatatgaa gcggtagagg
      901 aagaaaaagt cattcgtcct gaacttcatc ctgcaacgga ttcactgagt atgggcgaag
      961 tggtgcgtgc ggtaagcgaa gcgacccgtc acgaagccat attggtgaca gatgtaggtc
     1021 agaatcagat gatctctgcc cgctacttta aatataccag ggaacgtagt atcgttactt
     1081 cgggtggact cggcacgatg ggttttggcc ttccggcagc tatcggagct actttcggcc
     1141 gtcctgaccg cattgtatgt gtatttatgg gtgacggcgg actgcaaatg aacattcagg
     1201 aactgggtac gatcatggaa cagaaagctc cggtgaagat tatctgcctg aacaacaatt
     1261 atctcggcaa cgtgcgccaa tggcaggcta tgttctttaa tcgccgttat tcatttactc
     1321 cgatgctgaa tccggattac atgaaaatcg cttccgccta cgatattcct tccaaacgtg
     1381 tcttttcacg ggaagaattg aaagcggcca tcgacgaaat gctctcgaca gacggggcgt
     1441 tcctgctcga agcctgtgtg gtagaagaag gcaatgtcct cccgatgacc cctccgggcg
     1501 gttcagtcaa tcagatgttg ctggaatgtt aatccttaat ttagaaagtt atgagtgata
     1561 agacattata tacgattata gttcattctg aaaatatagc cggattgctg aatcaggtga
     1621 ccgctgtatt tacccgtcgg caaataaaca tcgagagttt gaacgtttct gcttcttcca
     1681 ttaaaggagt acataaatat acgatcacag cgtggactga taaggacact attgaaaagg
     1741 tggtgaagca gatcgaaaag aagattgatg tgattcaggc gcactatttt actgaagacg
     1801 agatttattt ccatgagata gccttatata aggtatctac tcctgctttt caggagactc
     1861 cggaagcatc taaagtgatc cgcagatata atgcccgcat tgtagaggtg aatccggtat
     1921 tctctatcgt cgagaagaac ggcatgagtg aagagattac ttccctttac gaagaacttc
     1981 gggctttgaa atgtgtgctg caatttgtcc gttcgggtcg tgtggctatt actaccagct
     2041 gtttcgaacg tgtgaatgag ttcctggacg gacaggaagc gaagtataag caaagtaaaa
     2101 aggaacagga gtaatgagtg aagaaaataa aatagggact tatcagtttg tggcagagcc
     2161 gtttcacgta gattttaacg gccgcctgac catgggcgtg ctgggaaatc atctgttgaa
     2221 ttgcgcaggt tttcatgcca gcgaccgtgg atttggtatt gctacgctga acgaggacaa
     2281 ttacacatgg gtgctttccc gcctggctat cgagctggat gagatgcctt accagtacga
     2341 gaagttctcg gttcagacat gggtggagaa tgtctatcgt ctctttaccg accgtaactt
     2401 tgccgtcatt gacaaggatg gaaagaagat cggctatgcc cgttccgtat gggcgatgat
     2461 caatctgaat acccgtaagc ctgccgatct gttggcattg catggaggaa gcatcgtcga
     2521 ttatatatgc gatgaaccct gcccgataga aaagccttcg cgtatcaagg tgacaagcaa
     2581 tcagcctgtt gcgacgctga cggcaaaata cagtgatatc gatattaacg gacacgtaaa
     2641 cagtattcgt tatatcgagc acatacttga cttgtttccg atagaactgt atcagacgaa
     2701 acgtatccgc cggtttgaaa tggcgtatgt ggctgaaagt tatttcggag atgaactctc
     2761 tttcttctgt gatgaggtga gtgaaaacga gtttcatgta gaggtgaaga aaaacggcag
     2821 cgaggtagta tgccgttcca aagtgatatt tgaataatat agagtataaa atcaattaat
     2881 aacagatggc gcaagtcatc aaaacaaaaa aacaaaaaaa atggcacagt tgaattttgg
     2941 cggaactgta gaaaatgtag ttatccgtga tgaatttcca ttggaaaaag ctcgtgaagt
     3001 attgaaaaat gaaacaatcg ctgtaatcgg ttatggcgta caaggtcccg gacaggctct
     3061 gaaccttcgt gataacggtt tcaatgtaat cgttggtcaa cgccagggaa agacatatga
     3121 caaagcggtt gctgacggat gggttccggg tgaaactttg ttcggtattg aagaagcttg
     3181 cgaaaaaggt acgatcatta tgtgcctgtt gtctgatgca gcagtaatgt ctgtatggcc
     3241 tactatcaag ccttacctga ctgcaggaaa agctctttat ttctctcatg gttttgctat
     3301 tacatggagt gaccgcacag gtgtagttcc tcctgcagat atcgacgtaa tcatggttgc
     3361 tcctaaaggt tcgggtacat ccttgcgtac tatgttcctt gaaggtcgcg ggttgaactc
     3421 ttcatacgct atctatcagg atgcaacagg caacgctatg gacagaacaa tcgcattggg
     3481 tatcggtatc ggttcaggtt atttgttcga aacaactttc atccgcgaag ctacttccga
     3541 cctgacaggc gaacgtggtt cattgatggg agctatccag ggtctgttgc tggcacaata
     3601 cgaagtgttg cgtgaaaacg gtcacactcc ttccgaagca ttcaacgaaa ctgtagaaga
     3661 gctgactcag tcattgatgc cgttgtttgc aaagaacggt atggactgga tgtatgctaa
     3721 ctgctctact acagctcaac gtggtgctct cgactggatg ggcccgttcc atgacgctat
     3781 caaaccggta gttgaaaaat tgtatcacag tgtaaagact ggtaacgaag cgcagatttc
     3841 aatcgactcc aactctaaac cggattatcg tgagaaactg gaagaagaac tgaaagcatt
     3901 gcgcgaaagc
//
