LOCUS       c00136_gnlPro..        14545 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HPMLHGED_136.
ACCESSION   c00136_gnlPro..
VERSION     c00136_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 23:03:00
            Original ID  :: gnl|Prokka|HPMLHGED_136
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 21593
            Orig. end    :: 36138
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14545
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[31593:36136]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14543
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14545
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14545
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(113..634)
                     /locus_tag="ctg136_21"
                     /transl_table=11
                     /translation="MSTINYDLSRIKALAFDVDGVLSSTTVPLHPSGEPMRTVNIKDGY
                     AIQLAVKKGLHIAIITGGRTEAVRIRFAALGVKDLYMGSAVKIHDYRDFRDKYGLSDDE
                     ILYMGDDVPDIEVMRECGLPCCPKDAVPEVKSVAKYISYADGGRGCGRDVVEQVLKAHG
                     KWMAEDAFGW"
     CDS             complement(615..1409)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg136_22"
                     /sec_met_domain="F420_oxidored (E-value: 1.2e-13, bitscore:
                     42.7, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRSIEDTPVVFLGAGNLATNLAKALYRKGFRIMQVYSRTEESAR
                     TLANEVEAEYITDLKDVSNEARLYIISLKDAAFVELLPQITDGKQHALLVHTAGSIPMN
                     IWEGHVERYGVFYPMQTFSKQREVDFREVPFFIEAKRPEDTELLKAVAGTLSDKVYEAD
                     SEQRRSLHLAAVFTCNFTNHMYALAAELLEKYHLPFDVMLPLIDETARKVHELAPRDAQ
                     TGPAVRYDENVMNKHLSMLADSQALQEIYKLMSKSIHEHHQL"
     CDS             complement(1417..1752)
                     /locus_tag="ctg136_23"
                     /transl_table=11
                     /translation="MGAVKANNNKDTYKATAVAFIVIGTLFLINKLLPFASIGLPWVMN
                     KDNLLLYASISFLIFKRDKSVGFVLLGLWLVMNIGLVMSLLGSLSGYLLPLALLIIGII
                     LFWVSKR"
     CDS             complement(1755..2498)
                     /locus_tag="ctg136_24"
                     /transl_table=11
                     /translation="MHSFVTNGVSVLFDFCLTAGFTIRFDVIVLCNSFFHNEYISQCKD
                     TISFLITIGLRYLCIHKSNENGNNMENFSELIKNRRSMRKFTDEELTQDEVVALMKAAL
                     MSPSSKRSNSWQFVVVDDKEKLKELSHCKEQASSFIADAALAIVVMADPLASDVWIEDA
                     SIASIMIQLQAEDLGLGSCWVQVRERFTATGMPSDEFVHGILDIPLQLQILSVIAIGHK
                     GMERKPFNEEHLQWEKIHINKFGGK"
     CDS             complement(2690..3232)
                     /locus_tag="ctg136_25"
                     /transl_table=11
                     /translation="MIEEMLAYNREFVKNEGYKEYITNKYPDKKIAILSCMDTRLTALL
                     PAALGIKNGDVKMIKNAGGVISHPFGSVIRSLLVAIFELGVEEIMVIAHSDCGACHMHS
                     EEMLEKMKARGINADYIHMMSFCGVDFHSWLDGFEDTEKSVRGTVDFIVHHPLIPSDVK
                     VHGFIIDSTTGELTRIV"
     CDS             complement(3419..5374)
                     /locus_tag="ctg136_26"
                     /transl_table=11
                     /translation="MKKIYSLVLLVAGVFSWGSCSLDEVNPNNSGQFSDGSYTLETYKA
                     FTNSCYTALINNIYQSSDYLVCTEAGTDIWEEPKSGSSYQRYHSYNGMKTDDSYYYKVW
                     QYSYLCINSCNIVIDGAENVTGDETEINECVAQARCLRAYYYMNLVEQFGNVDLQLKAA
                     DSENISFDAHRSTVPEIYAAIIEDLKFAVENLPVSFSDYYSRVTKKSAMGLLARAYING
                     AGYDLKDTDGVSFLEKAYDTATTMINNKAIYEWYMHPAFADVFNENNNRNNEEALFIAA
                     GAERNSDAYTNGNYSQSEMFRHFLPSLGTYTDLGLVDKTSNFVYGRPNSNIFLPSKYLM
                     DCFAADMNDSRFRYSFISAYSSYSIPAWGATYEYGGSACAKEITSTLATKFGIPASNIG
                     KKVYPHFNLESNSTADANYCQLAIWNADGTAKTTQDKTDGNILHPAMPLDPAEAHQYAV
                     YCSLKTLTEEEKAQYPGLVLNVFDLYDENGTARATYDKPSAASALWLSIYPALSKFNMP
                     GNKFVGRDVQRKTVDVMIMRMAEVYLIAAEASVRLNKGDAAKYINVLRTRAGAGTVSES
                     QVDLNYVFDEYARELCGECGRWYLLKRNAAFETRLAAYNKRAAEHFKKEFYLRPIPTKY
                     LDAINNPAEFGQNAGY"
     CDS             complement(5386..8526)
                     /locus_tag="ctg136_27"
                     /transl_table=11
                     /translation="MILGLTLLCAPSAISVYAENGVNDITVQAVMQTKTVKGTVLDENG
                     EPLIGVSIVVKGTSTGTITDFDGKFSINLPAGSKELVVSYIGYKEQAIIVSGNAPLNIK
                     MVPDTQALDEVVVIGYGTVKKRDLTGAVASVKSEDITMNPGVNPMDALQGKIAGLDITN
                     SSGQAGSSPTVQLRGTRSLQLDEDGNISSDAFKPTYIIDGMPGDIATLNPNDIESIEVL
                     KDASSTAIYGSSGANGVIIVTTKGSKSGKPVINFNAYAGTTLGAKVPKMRTGDSYINYI
                     KDSYKPVGTTNEEEIFGERYDAIKNSQWVNWGDEVLHSGLKQNYSISVAGGTEKTKAYF
                     SLNYTDEKSMYENDDYKVYSTRVRIDQEINKWMNAGINVQASFSNKNSRNAVLERALFA
                     TPLGTPYNEDGSITEFPIPGSSSDPNPLADEQDGVYKNNTKAGRAYVDAYLEWKPVKGL
                     SVKSQLGGSYSQSRAGKFMGEGSYNVLKGSTVAYGEATNKTGYNYKWENIVTYHNTFNK
                     DHDLTVTGVTSWNYNQSEEYYVYGENPATNDMLWYALQNADNKKLNSKYLMSKGMGFIG
                     RVNYSYKGKYLFSASSRYEADSRLSKDNRWNLFPAVSVGWRISDEAFMAGTKSWLDNLK
                     LRVGYGVAGTTAGIAEYSSMASLENVTTSLGGMTVPSAKFTEYITNRNLTWEKTHDLNI
                     GIDASFLNNRIDLTVDLYRTKTTDVILSQALPTSIMGNYTGSTTYKMNKNAAETENRGI
                     ELALNTRNIVKKDFTWSSTVTFTANKEKIKSLIEGQDMMFNAKKGDMVFKVGEGVGSFY
                     RYKVLGIWQYSEKETAALFGCEPGDIKLDLPSVKKDGNGYYYMNPEGERVDITAENPYG
                     VRADYDRQVIGRNTPDWTLGFKNNFRYKDFDLSVFLYARWGQMMNYGSVIGKYSPNPDY
                     NIPTYFTYYDKTIEADQDVLFYAIDKSKDRSAYEGYDSMYYVDGSFFKLKNVTLGYTLP
                     GKLTKRFGISNLRVYATMTNLFTYSPNKYVKNYDPEMNGSINFPLSRDCIFGLNLTF"
     CDS             9051..9827
                     /locus_tag="ctg136_28"
                     /transl_table=11
                     /translation="VVYGAGEFLDTSLPASKEKEEEIFGEMLEHLTQEASRTCILIEFR
                     NLDNSMFGYRFFRKNDFFPVNWLRVRNSLHSTQKAEDRFSPSRIRQIRKGLKNGAKVVE
                     AHTVEEIKEFSRMLHKVYSSRIRRYFPANDFFRHMNSMLIRGKQAKIFIVKYKEKIIGG
                     SVCIYSGENAFIWFSGGMRKTYALQSPGILAVWKALEDAHERGFRHMEFMDVGLPFRKH
                     GYRDFVLRFGGKQSSTRRWFRISWPWLNNLLVKFYV"
     CDS             10001..10405
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg136_29"
                     /sec_met_domain="Glyoxalase_4 (E-value: 3.5e-24, bitscore:
                     76.4, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGETKIELLEPTCPESTIAKFIENKGAGVHHVAFAVEDGVANALAEAESKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             10435..11988
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg136_30"
                     /sec_met_domain="CT_Btheta (E-value: 1.1e-290, bitscore:
                     955.2, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERRAVARIGGGEKAIAKQHEKGKYTARERIAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYLFAQDFTVTAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAKTEEEGLALIRTLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDSPN
                     KPYDMYEVISAIVDNGEFLEIQKDYAKNIIIGFARFNGQSVGIVANQPKFLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKDQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLSNPAKKHGNIPL
                     "
     CDS             12020..12940
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg136_31"
                     /sec_met_domain="OAD_gamma (E-value: 9.2e-15, bitscore:
                     46.2, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLLLLIGLTSCGEQKSNNKLLLNEVLIDNQNNFQD
                     DYGLHSAWIEIFNKSYGSADLAACLLKVSSQPGDTVTYFIPKGDILTLVKPRQHALFWA
                     DGEPNRGTFHTSFKLNPETANWVGLFDSGRKLLDQVVIPAGTLGPNQSYARISDGAADW
                     EVKGGSKDKYVTPSTNNKTLDSNAKMEKFEEHDSVGIGMSISAMSVVFCGLILLFIAFK
                     VVGKVAVNLSKRNAMKAKGIDKVEAKELSQAPGEVYAAISMALHEMQDEVHDVEETVLT
                     ITRVKRSYSPWSSKIYTLRENPNRK"
     CDS             12965..13399
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 66.7; E-value:
                     4e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg136_32"
                     /sec_met_domain="Biotin_lipoyl (E-value: 2.2e-21, bitscore:
                     66.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNSYKVTIGDIEDNIAHVEVNGTHYKVEMEKQPKTA
                     PKPVVVRPMPNSPAAPTTPVVKPAAPSTGKSGVKSPLPGVILDIKVNVGDTVKRGQTII
                     ILEAMKMENNINADKDGKVTAINVNKGDSVLEGNDLVIIE"
     CDS             13401..14543
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg136_33"
                     /sec_met_domain="OAD_beta (E-value: 3.6e-153, bitscore:
                     500.7, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFINFLGNNLADFWTYTGFANATVGHIVMILVGLFFIYLAVAK
                     EFEPMLLIPIGFGILIGNIPFNMDAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALEMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKHERVIRMKPPRAVSHTEKVIFP
                     IIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDTITILLGLTVGAS
                     TQASEFLTLDSIKIFALGALSFIIATASGVIFVKIFNLFLKKGNKINPLIGNAGVSAVP
                     DSARISQVVGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGIL"
ORIGIN
        1 ctcccaagcc tgacatcagt tctttccggc ggggagaatt ggaggctaat ataatctgat
       61 atttatctaa atttccaagc atagttttat ttatcattta gtgatttaca actcaccagc
      121 cgaaagcatc ttccgccatc cacttgccat gagctttcaa tacttgttcc accacatcac
      181 gtccacagcc acgaccgcca tcggcataag atatatactt cgcaaccgac ttaacttccg
      241 gaactgcatc tttgggacaa caaggcaacc cgcactcacg catcacttct atatcaggca
      301 catcatcgcc catatacaga atttcgtcat cagacagacc gtatttatcg cggaaatcac
      361 ggtaatcatg aattttcact gcagacccca tatacagatc cttcacaccc aatgctgcaa
      421 accggatacg taccgcttct gtccgtccac cggtaatgat agcaatatga agtcctttct
      481 ttaccgccag ctgaatggca taaccgtctt tgatattcac tgtacgcatc ggttctccgg
      541 aaggatgcaa cgggactgtt gtcgaactca atactccgtc aacatcaaaa gccagtgctt
      601 tgatgcggga tagatcataa ttgatggtgc tcatggatac ttttactcat taatttataa
      661 atttcctgca atgcctgact gtctgccagc atagaaagat gcttattcat cacattctcg
      721 tcatagcgta cagccggtcc ggtctgcgca tcacgaggag cgagttcatg cactttgcgt
      781 gccgtttcgt caatcagggg aagcatgaca tcaaatggca aatgatattt ttccagcaat
      841 tcggcggcaa gagcatacat atggttggta aagttacagg taaagacagc tgccagatga
      901 agacttctgc gttgctccga atcggcttcg tacaccttat cagagagtgt accggcaacc
      961 gctttcagca gctcggtatc ttccggtctt tttgcttcaa taaagaaagg tacttcccga
     1021 aaatcaactt cacgttgttt gctgaacgtc tgcatcggat aaaatactcc gtagcgttcc
     1081 acatgacctt cccaaatatt catcgggatg ctgcctgccg tatgcaccaa cagcgcatgc
     1141 tgcttcccat cagtgatctg aggcaacagt tcgacgaaag cggcatcttt caatgaaata
     1201 atatataatc tcgcttcatt cgatacgtct tttaaatcag tgatatattc cgcttccact
     1261 tcattggcta acgtacgagc cgattcttcc gttcggctgt acacctgcat gatacggaat
     1321 cctttccggt aaagcgcttt cgccagatta gttgccagat ttccggcacc gagaaacaca
     1381 acgggcgtat cttcaatact tcttttcatt gtttctttaa cgttttgaaa cccaaaataa
     1441 aataattccg atgatcaaca gtgccaatgg caacagataa ccggacaagg aaccgagcaa
     1501 tgacattacc agaccgatat tcattaccag ccacagtccc aacagcacaa agccgaccga
     1561 cttgtcacgc ttgaaaataa gaaaactgat agaggcatac aacaacaaat tgtccttatt
     1621 catcacccaa ggcaaaccta tagaagcaaa ggggagcagt ttatttatca ggaaaagagt
     1681 tccgatgaca ataaaagcga cggcagtagc cttataagta tctttattat tatttgcttt
     1741 gacagctccc atcgttattt tcctccgaac ttattaatat gaattttctc ccactgaagg
     1801 tgttcttcgt tgaaaggctt acgttccatt cccttatgtc cgatggcaat cacggaaaga
     1861 atctgcagtt gcaaaggaat atccaaaatt ccatgaacaa actcgtcaga cggcattccg
     1921 gttgcagtga aacgttcgcg aacctgtacc caacagcttc ccagccccaa atcttccgcc
     1981 tgcaactgta tcatgatgga agcaatagaa gcatcttcaa tccacacatc gcttgccaac
     2041 ggatcggcca tcacaacaat cgccaaagca gcgtctgcaa tgaaagaaga agcctgttct
     2101 ttgcagtgag acagttcttt caacttttct ttatcatcga ctaccacaaa ctgccagcta
     2161 ttactacgtt tggaactggg agacattaag gcagctttca tcagtgccac aacctcatcc
     2221 tgtgttaact cctcatccgt aaatttgcgc atactgcggc gattctttat cagttcactg
     2281 aaattttcca tattatttcc gttttcattt gatttatgta tgcaaagata gcgcaaaccg
     2341 atcgtaataa gaaatgaaat tgtatctttg cactgagaaa tatattcatt atgaaaaaac
     2401 gaattacaca agacgattac atcaaagcga atcgtaaagc cagccgtgag gcagaaatca
     2461 aagagcacgg acaccccgtt tgttacaaac gagtgcatga gtcaaagaaa gtatataacc
     2521 gtagaaagat aaaggcagcc gataaaaagc tgccttattt ttttcatttg ggatagtgtc
     2581 ggtatcccaa tgacatagtg acaccatgag acagtgatag tgacactatc ctgttgcgat
     2641 agtgacacca tgttttatgc agttcctgat aggcagaaag ggcgatttcc tatacaattc
     2701 gcgtcagttc tccagtagtg gagtctatga taaacccgtg cactttcacg tccgacggaa
     2761 tcaaaggatg atgaactata aaatcgaccg ttccccttac cgacttctcc gtatcttcaa
     2821 agccatctag ccaagaatga aaatcgactc cacaaaaact catcatatga atataatcgg
     2881 cattaatacc ccgtgccttc atcttctcaa gcatttcttc actgtgcata tggcaggctc
     2941 cacaatcaga atgggcaatc accattattt cctccacacc taactcgaag atagcgacaa
     3001 gcagactgcg aatcacacta ccgaaaggat gggaaatgac gcctcctgca ttcttgatca
     3061 ttttaacgtc tccgttctta atgcctagtg cggccgggag taaagctgtc aggcgtgtat
     3121 ccatacagga taagatagca atctttttat cgggatattt attcgttata tattctttat
     3181 atccctcgtt cttaacgaac tctctgttat aagcaagcat ttcttctatc atagcactat
     3241 tttgtttgga cacacaaaaa taaagaaaat aataaaaggc tgtatcagga aacaatgaaa
     3301 atataccgga aatccttttt aaacttttac gcaggataca ggtctggaaa caaagagccg
     3361 gacaagagaa atctcctgcc cggctcctat taattatgct tgattattaa ttaactgatt
     3421 aataaccggc gttttgtccg aattctgccg gattattgat cgcatccaga tatttcgtag
     3481 gaataggacg caaatagaat tctttcttaa agtgctcggc agcacgctta ttataagcag
     3541 ccaaacgagt ctcaaaagca gcattacgtt tcagcaaata ccagcggcca cattcgccac
     3601 aaagttcacg ggcatattca tcgaaaacat aattcagatc cacttgcgac tcactgaccg
     3661 taccggcacc ggcacgcgta cggagtacat taatatattt ggcagcatct cccttgttca
     3721 agcgtaccga tgcttcagca gcaatcaggt aaacttctgc catacgcatg atcatcacat
     3781 ccacagtttt tctctgaacg tctctgccga caaacttatt acccggcata ttgaatttag
     3841 aaagagccgg ataaatagat aaccacaaag cactggcagc actaggcttg tcataggtag
     3901 ccctggctgt tccattctca tcgtaaagat cgaaaacatt aagaaccaac cccggatatt
     3961 gagctttttc ctcttctgtc agcgtcttca aagaacaata aacggcatat tgatgagctt
     4021 ctgccggatc taaaggcata gcaggatgaa gaatattacc atctgtttta tcctgagtag
     4081 tcttcgctgt tccatctgca ttccagatag ccagctggca gtaattagca tcggctgtac
     4141 tattggattc caagttaaaa tgaggataaa ctttcttacc tatattagat gcgggaatac
     4201 caaatttagt agcaagtgtg cttgtgattt ctttggcaca cgctgaacct ccatattcat
     4261 aagtcgcccc ccatgccggt attgaataag acgagtaagc tgagataaat gaataacgaa
     4321 aacgagagtc gttcatatca gcagcaaaac agtccatcag atatttggat ggcaggaaga
     4381 tattactgtt cggacgaccg tatacgaagt ttgaagtctt gtcgaccaaa cccaggtccg
     4441 tatatgttcc caacgaaggt aagaagtgac ggaacatttc actttgtgag tagttaccat
     4501 tggtgtaagc gtccgaattt ctttcggcac ccgcagctat gaacagagct tcttcattgt
     4561 tacgattatt attttcgttg aatacatcgg caaaagcggg atgcatatac cactcataaa
     4621 tcgctttatt attaatcatg gttgtcgccg tatcataggc tttttccagg aagctgacac
     4681 catcggtatc tttcagatca taaccggcac cattaatata tgcacgtgcc aataatccca
     4741 tcgccgattt ctttgtaacg cggctatagt aatcactgaa acttacaggc agattctcta
     4801 cggcaaactt caggtcttcg ataatggcag cataaatttc gggaacggta gaacggtgag
     4861 catcaaaaga aatattctcg ctatcggcag ccttcaactg caaatcgaca tttccaaact
     4921 gctccaccag attcatataa tagtaagcac gcagacatct ggcctgtgcc acacattcat
     4981 taatttcagt ctcatcccct gtcacattct cagctccgtc aatcacaata ttacagctgt
     5041 tgatacacag ataagaatat tgccacactt tataataata gctatcatcg gttttcatac
     5101 cgttataact atgataacgc tgatagctgg aacccgattt aggttcttcc caaatatcag
     5161 tacccgcttc cgtacaaacc agatagtcac tactctgata gatgttgttg atcaaagctg
     5221 tatagcacga gttggtgaat gccttataag tttccaatgt ataagaacca tcggagaact
     5281 gacccgagtt gttggggttc acttcatcaa gactgcaaga gccccaagaa aaaacaccgg
     5341 caacaagtag aactaaacta tatatctttt tcatattgct attttttaga aagttaaatt
     5401 aagaccaaat atgcaatcac gagacaatgg gaagttgatg cttccgttca tttccggatc
     5461 gtaattcttc acatatttgt ttggcgaata agtaaacagg ttggtcattg tcgcataaac
     5521 tctcagatta ctgataccaa aacgttttgt aagtttaccg ggtaacgtat aacccaatgt
     5581 tacgttttta agtttaaaga atgatccatc cacataatac atcgaatcat atccttcata
     5641 agcacttcta tccttggatt tatcgatagc atagaacaag acatcctgat ctgcttcgat
     5701 cgtcttgtca tagtaagtaa aataagtagg aatattgtaa tccgggttag gcgaatattt
     5761 acctatcaca ctaccatagt tcatcatttg cccccaacgt gcataaagga agacagacaa
     5821 atcaaaatct ttgtatctga aattattctt aaagcccaat gtccagtccg gagtattacg
     5881 acctattacc tgacgatcat aatccgcacg tacaccataa ggattttctg ccgtaatatc
     5941 aacgcgctct ccttcaggat tcatataata ataaccattt ccgtccttct tcacactagg
     6001 taaatccagc ttaatatcgc ccggttcgca tccgaacaaa gcagcagttt ccttttcgct
     6061 atattgccag atacccaaca ctttatatct atagaaagaa ccgactcctt cgccgacttt
     6121 gaacaccata tcaccctttt ttgcattgaa catcatatcc tgcccttcga tcaaagattt
     6181 aattttttct ttgttggcgg taaatgtcac tgttgagctc caagtaaaat ctttcttcac
     6241 aatattacgg gtattaagag caagttcaat accgcgattt tctgtttcag cagcattctt
     6301 gttcatttta taagtagtgc tacctgtgta attacccata atagatgtcg gcaatgcctg
     6361 cgaaagaatt acatccgttg tttttgtccg atacaaatcc accgtcagat caatacgatt
     6421 attgaggaag ctggcatcaa taccaatatt caagtcatga gtcttttccc atgtcagatt
     6481 acggttagtg atatactccg taaacttggc tgacggaaca gtcattcctc ccaaagaagt
     6541 tgtcacattt tccaaagatg ccatagaact gtattcagca ataccggcag tagttccggc
     6601 aacaccatag cctacacgca gtttcaagtt atccaaccag ctttttgtac cagccataaa
     6661 tgcttcatcc gagattctcc agcctacaga aactgccggg aataaattcc atctattgtc
     6721 tttcgacaaa cgggaatccg cttcataacg actggaagca gagaacaggt atttaccttt
     6781 gtatgagtag ttgacacgac cgataaagcc catccccttc gacatcagat atttgctgtt
     6841 cagtttctta ttatcagcat tctgcaatgc ataccacaac atatcattgg tcgccgggtt
     6901 ttcaccatag acataatatt cttcactctg attgtaattc caggaagtaa cccctgtaac
     6961 cgtcaggtca tgatccttat taaatgtatt gtgataagtt actatgtttt cccatttgta
     7021 attatatccc gtcttattgg tagcttcgcc atatgccacc gtactgcctt tcaacacatt
     7081 ataagagcct tctcccataa atttaccggc acgagattga gaataactgc ctccaagctg
     7141 tgacttgaca gacaatcctt ttaccggttt ccattccaga taagcgtcaa cataagccct
     7201 tcctgcttta gtattattct tatatactcc atcctgttcg tctgctaacg gattcgggtc
     7261 tgatgatgaa cctggaatcg ggaattccgt gatagagccg tcttcattat aaggagtacc
     7321 taacggggtg gcaaacaatg ctctttccaa aacggcatta cgtgaattct tgttggagaa
     7381 agatgcctga acattaatac cggcattcat ccatttattg atttcctgat ctatacggac
     7441 acgggtagag tacactttat agtcatcatt ctcatacata ctcttctcat cagtatagtt
     7501 caacgagaaa taggctttcg tcttctcagt acctccggca acggaaatac tataattctg
     7561 cttcaaacct gagtgtaata cttcatctcc ccagtttacc cattggctgt ttttgatggc
     7621 atcgtatctt tcaccgaaaa tttcctcctc attagtagta ccgacaggct tataagaatc
     7681 ttttatataa ttaatgtatg agtcacccgt acgcatctta ggaactttag ctcctaaagt
     7741 cgttccggca taagcattga aattgatgac cggttttcca ctcttggatc ctttcgtagt
     7801 cacgataata acaccattcg caccacttga accgtagata gccgtagaag atgcatcttt
     7861 cagtacttcg atagattcaa tatcattggg attcaaggta gcaatatcac ccggcatacc
     7921 atcgataata taagtcggct taaatgcatc ggaagaaata ttaccatcct catccaactg
     7981 caaagagcgg gtaccacgca actgaactgt cggtgacgaa cctgcctgac ctgaagaatt
     8041 agtgatatcc agacctgcaa ttttaccttg cagcgcatcc atcggattca cgcccggatt
     8101 catggtgata tcctctgatt tcacagaagc aaccgcacct gtcaaatcac gtttctttac
     8161 cgtaccgtaa ccgatgacca ctacctcatc caaagcctgt gtatccggaa ccatctttat
     8221 attcagcggg gcatttccgc tcacaataat agcctgttct ttatatccga tataagaaac
     8281 aaccagttct ttacttccgg ccggaagatt aatggagaac ttaccgtcaa aatcagttat
     8341 cgtacctgta cttgtacctt tcaccacaat agagacaccg atcaacggtt ctccattttc
     8401 atctaaaaca gttcctttca ctgtctttgt ctgcatgacg gcttgcacag taatatcatt
     8461 cacaccattt tctgcataaa cagatatggc agaaggggca cacaataaag tcagccctaa
     8521 aatcatggaa acgcgtctat gctgtgtctt ccacgcttca acaaatgcat tctctctcat
     8581 tcgttttaat ttaaagttaa tattaatttt cctttgttta gtaaaataca attagcataa
     8641 tcttttacat agacgtttcc attttacttc tgtactcaca aaggacgaca ataatacaaa
     8701 aattcgcttt tccaagcctt tttttcctca aatatatgca aaggataaaa agacaaattt
     8761 taggctaagc caacaaattc tcttttttat tgttgaatga agaataaaaa gtgtaaattt
     8821 gtatttggat gccacttaaa ctaacaacat attatcgcgg aaaagacatt cctgatttac
     8881 cgggaaccaa tacttttcat tccaaggagt tgtttcagat ctatgaatcg actccgggat
     8941 ataccccgct actgatagtg gcaacagaag aaggcagacc tgtagcacgc ctgcttgccg
     9001 ccatacgcaa gaccaaaaag tggcttccct cctctcttgt caaacaatgt gtggtatatg
     9061 gtgcaggtga atttctggac acttctctac cggcaagtaa agagaaggag gaagaaattt
     9121 tcggtgaaat gctggagcat ctcacacaag aagcatcacg cacctgcatt cttattgaat
     9181 tccgcaatct ggataattcc atgttcggtt accgtttctt ccgaaagaac gacttttttc
     9241 cggtcaactg gctgcgtgtc cgtaactctc tgcatagtac gcagaaagcg gaagaccgtt
     9301 tcagcccgtc acgtatccgt cagatccgga aaggactcaa aaacggagcc aaagtagtag
     9361 aagcccatac ggtggaagag attaaggaat tctcgcggat gctgcacaaa gtttattctt
     9421 cacgaatacg gagatatttc cctgccaatg actttttccg ccacatgaac agcatgctta
     9481 tcagaggaaa acaggcaaaa atattcatcg taaaatacaa ggaaaagatt atcggcggct
     9541 ccgtctgcat ctattccggc gaaaatgctt ttatctggtt ttcaggagga atgcgaaaga
     9601 cgtatgcact gcagtcaccc ggcatactgg cagtatggaa agcacttgaa gatgcccatg
     9661 aacggggatt ccgtcacatg gagttcatgg atgtaggact tcccttccgc aaacatggtt
     9721 atcgtgattt cgtactccgt ttcggaggca aacaaagcag tacccgccgc tggttccgta
     9781 tcagctggcc atggctgaat aatcttctgg tcaagtttta tgtctaaatg taatctcaag
     9841 attacaaaac ccgtctttgt cacccatccg gagcattttt tatgctttat tccccaataa
     9901 ttaaatgcag aaatatttct ttattagaca agaaatgtct ttctttgtgc tgttttatgc
     9961 catataagca cataattaaa ccatataaaa aaatatagtt atgaagattt cacacattga
    10021 gcatctgggc attgctgtaa aaagcatcga agaagccctt ccttactacg aaaacgtatt
    10081 gggtctgaaa tgttacaaca tcgaaacagt agaagatcaa aaagtaagaa ccgctttttt
    10141 aaaggtaggt gaaacaaaaa tcgaattgtt ggagccgact tgccccgaaa gcaccattgc
    10201 taaatttatt gaaaacaaag gtgcaggtgt tcatcacgta gcatttgccg tagaagatgg
    10261 cgtagctaat gctttggcag aagcagaaag caaagaaatc cgtctgattg acaaggctcc
    10321 ccgcaaaggt gccgaaggtc tgaacatcgc tttccttcac ccgaaatcaa cactgggtgt
    10381 gctgacagaa ctctgcgaac actaatcata aactctaaaa aacaacaaga actcatgagt
    10441 aatcaacttg aaaaaattaa agagcttatt gaacgccgtg ccgttgcacg catcggaggc
    10501 ggcgaaaaag caattgcgaa gcaacatgaa aaagggaaat acacagcgcg tgagcgtata
    10561 gccatgctgt tggatgaagg tagcttcgaa gaaatggaca tgttcgttga gcacagatgc
    10621 acgaacttcg gcatggagaa aaagcactat ccgggtgatg gtgtagtaac cggttgcggt
    10681 actatcgaag gtcgtctcgt atatcttttt gcacaggact ttaccgttac tgcaggttca
    10741 ctgtcggaaa caatgtcact gaagatctgt aagattatgg atcaggcaat gaagatgggt
    10801 gctccttgta tcggtatcaa tgactcgggt ggtgcacgta tccaagaagg tattaacgct
    10861 ttggcaggtt acgcagaaat cttccagcgc aatatcctcg cttcgggtgt cattccgcag
    10921 atttccggta tcttcgggcc ttgtgccggc ggtgctgttt attctccggc actgacagac
    10981 ttcacactga tgatggaagg tacttcttat atgttcctta caggtccgaa agtagtgaaa
    11041 actgtaaccg gtgaagacgt aagccaggaa aacctcggcg gagcaagcgt tcactctacc
    11101 aaatcgggtg ttactcattt cactgccaaa acagaagaag aaggtctggc attgatccgc
    11161 acacttctga gctatattcc tcaaaacaac ctcgaagaag ctccatacgt ggattgcaca
    11221 gatccgatcg accgtctgga agattctctg aacgatatta tccccgacag ccccaacaaa
    11281 ccgtatgata tgtacgaggt tatcagcgct atcgtggaca acggcgaatt cctggaaatc
    11341 cagaaagact atgccaagaa tatcattatc ggttttgccc gtttcaacgg tcagtctgta
    11401 ggtattgtag ccaatcagcc taaattcctt gccggtgtac tcgacagcaa cgcatctcgc
    11461 aaaggcgcac gtttcgttcg tttctgcgat gctttcaata tccctatcgt gtcgttggta
    11521 gacgtaccgg gattccttcc gggaacaggc caggaataca atggcgttat ccttcatggt
    11581 gccaaactgc tgtatgctta cggtgaagct accgtaccta aagtaacaat cacattgcgt
    11641 aaatcttacg gtggttctca catcgtgatg agctgtaagc aacttcgcgg tgatatgaac
    11701 tatgcttggc ctacagctga aatcgctgta atgggtggtg ccggcgcagt agaagtattg
    11761 tacgcgcgtg aagccaaaga ccaggaaaat ccggctcagt tccttgccga aaaagaagca
    11821 gaatatacaa aactgtttgc caatccttat aatgcagcta agtatggtta catcgatgat
    11881 gtcatcgaac cccgtaacac acgtttccgc gtgatccgtg ctttgcagca gttgcagact
    11941 aagaaactgt ctaacccggc gaagaaacat ggtaatattc cgttgtaatc caacttttca
    12001 cattaaaaca agaacgatta tgaacaaaac caaaatcgga atattccttt ctctgctgtt
    12061 gctgattgga ttgacttcct gcggagagca aaagtcgaac aataagctat tgctgaatga
    12121 agtcttgata gacaatcaaa acaactttca ggatgactac ggcttgcaca gtgcatggat
    12181 tgaaatattc aacaaatcat acggtagcgc agacttagca gcttgtttat tgaaagtaag
    12241 cagccagccg ggcgatacag taacctattt tatcccgaaa ggtgacatac ttacattagt
    12301 aaagccacgc caacatgcgt tattttgggc agacggcgaa cctaatcgtg gtaccttcca
    12361 taccagcttc aaactgaacc ctgaaacagc caattgggtc ggtctttttg attcaggcag
    12421 aaagctactt gatcaagttg tcataccagc aggaacttta ggtcccaacc agtcttatgc
    12481 acgcataagc gacggagcag cagactggga agtaaaaggc ggaagcaaag acaaatacgt
    12541 aaccccgagc acgaacaaca aaacccttga cagtaatgcc aagatggaaa agttcgaaga
    12601 acatgactca gtcggtatcg gtatgtctat ttcagccatg agcgtagtat tctgcggatt
    12661 gattcttctc ttcattgcct tcaaggtggt aggtaaagtt gctgtcaacc tgagcaaacg
    12721 caatgcgatg aaggctaaag gcatcgataa agtcgaagcg aaagagcttt cacaggctcc
    12781 gggtgaagtt tatgctgcta tttcaatggc attacacgaa atgcaggatg aggtacatga
    12841 cgtagaagaa acggtgctga ccatcactcg tgtgaaacgc agttattcac cgtggagttc
    12901 gaagatttac accttgcgtg aaaatcctaa cagaaagtaa atcattccct aaaaagataa
    12961 aacgatgaaa gaatataaat ataaaatcaa cggtaactca tacaaagtaa ccatcggaga
    13021 tattgaagat aatatcgctc atgtagaagt gaacggtacg cactacaaag tagaaatgga
    13081 gaaacaaccg aaaactgctc ccaaaccggt agtagtacgt cctatgccta actcaccggc
    13141 tgctcctacc acaccggtag taaaaccggc tgctccttct acaggcaaat caggcgttaa
    13201 gtccccgcta ccaggcgtta tccttgacat caaagtaaat gtaggtgata cagtgaaaag
    13261 aggacagact atcattatat tggaagccat gaagatggaa aacaatatca atgcagacaa
    13321 agacggtaaa gtgactgcta tcaatgtcaa caagggagat tctgttcttg aaggtaatga
    13381 cctcgtaatt attgaataat atgggagatt ttattaactt tttaggaaat aaccttgccg
    13441 acttctggac ctacacggga tttgccaacg cgacagttgg tcatatcgtg atgatcctcg
    13501 ttggcttgtt cttcatctat ttggctgtag ccaaagagtt cgagccgatg ttgttaattc
    13561 ctatcggatt cggtatcctg atcggtaata tacccttcaa tatggacgcc ggactaaaag
    13621 tcggtatata tgaagaaggt tctgtattga acatattgta tcagggagta acgtccggct
    13681 ggtatccacc gctcatcttc ttaggtatcg gtgccatgac agacttctcg gcgctgatct
    13741 ccaatccgaa gctgatgctg attggtgcag ctgcccagtt tggtatcttc ggtgcataca
    13801 tgatcgcatt ggaaatggga tttgacccga tgcaggccgg tgctatcggt atcatcggtg
    13861 gagcagatgg tccgacagct atcttccttt cgtccaagct ggcacctaac ttaatgggag
    13921 ccattgcggt atccgcctac tcctatatgg cgttagttcc ggtgatacag ccgcctatca
    13981 tgcgtctgct caccaccaaa cacgaacgcg ttatccgtat gaaaccgcca cgtgccgttt
    14041 ctcatacaga gaaagtgatt ttcccgatta tcggtctgtt gctgacctgc ttcctggttc
    14101 cttccggtct gcctctgttg ggtatgctgt tcttcggtaa cctgttgaaa gaaagtggtg
    14161 taacccgtcg tctggctaac acagccagcg gtccgctgat tgacacaatc actatcctgt
    14221 taggtttgac cgtaggtgct tctactcagg cttctgagtt cctgacactc gactccatca
    14281 agatcttcgc cctcggtgct ttgtcattta tcattgctac cgcatcaggt gtgatcttcg
    14341 ttaagatctt caacctcttc ctcaagaagg gcaataagat caatccgttg atcggtaatg
    14401 caggtgtatc tgccgttccc gactctgcac gtatctcaca agttgtcggt ctggaatatg
    14461 atcctaccaa ctacttgctg atgcacgcta tgggtccgaa cgtagcaggt gtaatcggtt
    14521 cggctgttgc tgccggtatc ctgtt
//
