LOCUS       c00460_gnlPro..        15628 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HPMLHGED_460.
ACCESSION   c00460_gnlPro..
VERSION     c00460_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 23:03:00
            Original ID  :: gnl|Prokka|HPMLHGED_460
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 32293
            Orig. end    :: 47921
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15628
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[42293:47443]"
                     /cutoff="2000"
                     /detection_rule="(Complex1_51K and minimum(5, [FMN_bind,
                     FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N,
                     SLBB]))"
                     /neighbourhood="10000"
                     /product="Rnf_complex"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..15150
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="(Complex1_51K and minimum(5, [FMN_bind,
                     FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N,
                     SLBB]))"
                     /neighbourhood="10000"
                     /product="Rnf_complex"
                     /protocluster_number="1"
     cand_cluster    1..15628
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Complex1_51K and minimum(5, [FMN_bind,
                     FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N,
                     SLBB]))"
                     /kind="single"
                     /product="Rnf_complex"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15628
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Rnf_complex"
                     /region_number="1"
                     /rules="(Complex1_51K and minimum(5, [FMN_bind, FeS, Fer4,
                     Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N, SLBB]))"
                     /tool="gutsmash"
     CDS             complement(276..1460)
                     /locus_tag="ctg460_30"
                     /transl_table=11
                     /translation="MRNAEKCILLLLIIILSSCTSKVEKKLNSDANLLKIDWKHVSNVI
                     DYSPMVEDSVLMFHLETNDSCLIGEITKLICLNNLIYIADNISKSIFVFDMSGKLRTKI
                     HSVGSGPGEYTNISYFTVHGTDVILFDHYMGKFLFYDASGKFIRDKGIGNIWAEELFCM
                     NDKLYLPNSSNTKEGFYKLFTIDLNSSDKIEKFFPFDEPKNNQGFGEVSYAQLGNEALL
                     CFFPYDELYMIKDEEISLLYKIDFGDRRLPKQFIEGDGTIALRTAIRDNYVTGIDRILQ
                     SNKYVFLQFGDSENNYIAIYNKETGEIHTTKHLQNVKLGNLQIQSNDAGVIIQDERIIQ
                     CYNADYWNFPGTLEQLESNDTHFYTEELRQKFLKLAKTDGSESNPIILIQKMKK"
     CDS             complement(1477..1857)
                     /locus_tag="ctg460_31"
                     /transl_table=11
                     /translation="MKKKMIYVVAALMISAVAVFNVITVLEANHVYDLTMTSIDALSEN
                     GDGEDQESNDHGSGKFFYETLRGKPDNCILYRNVHISGRIVYTEKEASLGGDWVSSKTE
                     GMRDKCPRDGNGCTAYTCQTTN"
     CDS             complement(1870..2238)
                     /locus_tag="ctg460_32"
                     /transl_table=11
                     /translation="MKYANSLFAQKRYDEAITVLKRANLVSCHPNIYNLLGQCYQASGN
                     FVDAEKCYKVSTQLLPIRIYPYYLLAKLYAEPSFFHETEMKEMINIVLSKEPKVDSKAI
                     HEMRMEMNSLLNNQLLTN"
     CDS             complement(2358..3662)
                     /locus_tag="ctg460_33"
                     /transl_table=11
                     /translation="MKNNKKSVFLSILITVIFSVMLCSAFFVRYSIYDNYLLLFPISLG
                     ICLVSVVAFFSFMARNRRFRISVPDMLISILVVYYIARYDYELQLADWKIIYAILLLIL
                     WYASRILLTNVAMSRTILYGGIVAIGCILSLWGVLQLHGFLPSNHVLFAITGPFYNPGP
                     YSGYLAMIFPIGLGCLLESTGKVRYLWLVAFSLMLCILPAGMSRSAWLALLFSSLWVLA
                     IHFKWIIKAKHYLRVHRYIAFLCCVLVTMIVACASVLLFQMKADSANGRLFIWKTTCKV
                     IADKPFFGYGPGAFSQVYGEKQSAYFASGNYTEQEERVAGAPEYAFNEFLQICVEGGII
                     LLMLFLSLIVWGIGKGIANKETIACSGLISLLIFSLSSYPFQILPFLMLGTLLLSICVS
                     DFERVRNFGFQCIHALLLPVALLAAMYFVSMKYGM"
     CDS             complement(4145..4879)
                     /locus_tag="ctg460_34"
                     /transl_table=11
                     /translation="MNKRMRKLLKRLGYLFFSLFVLFQVYLSVRIYWLVSCAIPTYSMS
                     PTLVGGDYIFASMQIPGRRIWEEDATHPGHYLIHRKEGVRRVQKKDVVVFNFPYAENKE
                     KMIIGDDVFYCKRCAAVPGETYQWMVNDEWRSVYLPEIGDSIRIDSINYNDYRKCIEYE
                     TESLMRMDEAGQVYLADTLLGVYCFQHDYYFMCGDNTNDSYDSRYWGILPDDFILGVGQ
                     IIWFSRDQKTKQIRWNRIFKKI"
     CDS             complement(5577..5726)
                     /locus_tag="ctg460_35"
                     /transl_table=11
                     /translation="MQEYRLILYKNIYKYPSFFALKVFLGLKPRRCSFKTKVSFLTDEP
                     FYLW"
     CDS             complement(5899..7452)
                     /locus_tag="ctg460_36"
                     /transl_table=11
                     /translation="MAEQRRNSRNTKSTKVQPVNDYGRIQPQAPELEEAVLGALMIEKD
                     AYSLVSEILRPESFYEHRHQLIYAAITDLAVNQKPVDILTVKEQLSKRGELEEVGGPFY
                     ITQLSSKVASSAHIEYHARIIAQKSLARELITFTSNIQSKAFDETLDVDDLMQEAEGKL
                     FEISQQNMKKDYTQINPVIDEAYKLIQKAAARTDGLSGLESGFTKLDKMTSGWQNSDLI
                     IIAARPAMGKTAFVLSMAKNIAVDYRNPVALFSLEMSNVQLVNRLITNVCEIPSEKIKS
                     GQLASYEWQQLDYKLKDLLDAPLYVDDTPSLSVFELRTKARRLVREHGVRIIIIDYLQL
                     MNASGMAFGSRQEEVSTISRSLKGLAKELNIPIIALSQLNRGVESREGIDGKRPQLSDL
                     RESGAIEQDADMVCFIHRPEYYKIYQDDRGNDLRGMAEIVIAKHRNGAVGEVLLRFKGE
                     FTRFSNPEDDMVIPMPGEPAGAMLGSKLNAGAMAPPPPEPDFVPQGNNPFGATEGPLPF
                     "
     CDS             7651..8475
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GHMP_kinases_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GHMP_kinases_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg460_37"
                     /sec_met_domain="GHMP_kinases_C (E-value: 2.4e-10,
                     bitscore: 32.3, seeds: 112, tool: rule-based-clusters)"
                     /sec_met_domain="GHMP_kinases_N (E-value: 5.6e-10,
                     bitscore: 31.0, seeds: 447, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITFPNAKINLGLSITEKRPDGYHNLETVFYPVALEDALEIRTSP
                     EADKKFSLHQYGMEISGNPEDNLVVKAYLLLDKEFHLSPIEIHLYKHIPSGAGLGGGSS
                     DAAFMLKLLNEHFQLNLSEDQLEIYAATLGADCAFFIRNAPTFAEGIGNIFSPIPLSLK
                     GYQILIIKPDVFVSTREAFANIHPHHPEYSIKEAIKRPANEWKEILINDFEDSVFPQHP
                     VIGEIKAELYRQGAVYASMSGSGSSVYGLFEPEGTLPETDWGTNVFRFKGRL"
     CDS             complement(8708..9742)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GDP_Man_Dehyd"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg460_38"
                     /sec_met_domain="GDP_Man_Dehyd (E-value: 3.1e-52, bitscore:
                     169.5, seeds: 258, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKERILVTGGTGYIGSHTVVELQNSGYEVIIIDNLSNSSADVVDN
                     IEKVSGIRPAFEKLDCLDFAGLDAVFAKYKGIKAIIHFAASKAVGESVEKPLLYYRNNL
                     VSLINLLELMPKHGVEGIVFSSSCTVYGQPDELPVTEKAPIKKAESPYGNTKQINEEII
                     RDTIASGAPINAILLRYFNPIGAHPTALLGELPNGVPQNLIPYLTQTAMGIREKLSVFG
                     DDYDTPDGSCIRDFINVVDLAKAHVIAIRRILEQKQKEKVEVFNIGTGRGVSVLELING
                     FEKATGVKLNYQIVGRRAGDIEKVWANPDFANQELGWKAVETLEDTLRSAWNWQLKLRE
                     RGIQ"
     CDS             complement(10001..10573)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Rnf-Nqr"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg460_39"
                     /sec_met_domain="Rnf-Nqr (E-value: 8.6e-63, bitscore:
                     203.0, seeds: 650, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYILIFISAIFVNNIVLSQFLGICPFLGVSKKVETAMGMSAAVA
                     FVLTIATIVTFLIQKFVLDAFGLGYLQTITFILVIAGLVQMVEIILKKVSPSLYQALGV
                     FLPLITTNCCILGVAILVIQKDFDLLTGVVYAFSTALGFGLALVLFAGLREQMTLVKIP
                     KGMQGTPIALITAGLLAMAFMGFSGVV"
     CDS             complement(10596..11180)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Rnf-Nqr"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg460_40"
                     /sec_met_domain="Rnf-Nqr (E-value: 7.1e-71, bitscore:
                     229.3, seeds: 650, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNFKVMMNGVIKENPIFVLLLGMCPTLGTTSSAINGMGMGLATM
                     FVLICSNVVISSIKNLIPDMVRIPSFIVVIASFVTLLQMIMQAYVPDLYATLGLFIPLI
                     VVNCIVLGRAEAFAAKNNPLASMFDGIGMGFGFTIALTLLGAVREFLGTGKIFNLTILP
                     EEYGMLIFVLAPGAFIALGYLIAIINSLKKA"
     CDS             complement(11198..11881)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: FMN_bind"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg460_41"
                     /sec_met_domain="FMN_bind (E-value: 3.1e-23, bitscore:
                     73.8, seeds: 891, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLVLTGVTAVSVALLAYVNELTKGPIAEANAKTLNEALKKVLPE
                     YTNNPVAESDTVFSEKDGKKIVDFIIYPAKNGEKWVGSAVEAKSMGFGGELKVLVGFDA
                     EGKIYNYSLLAHAETPGLGSKADKWFGAYDPAKNEKPVSHEESAKSILGMNPGETPLAV
                     TKDMNGQVDAITASTITSRAFLNAVNAAYQAYKGGEVDTNSGASQKNEPAVAPEGEAAA
                     NDTNN"
     CDS             complement(11908..12900)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: NQR2_RnfD_RnfE"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg460_42"
                     /sec_met_domain="NQR2_RnfD_RnfE (E-value: 2.1e-120,
                     bitscore: 393.0, seeds: 472, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENKLIVSLSPHVHGGDSVQKNMYGVLIALIPAFLVSLYFFGLGA
                     LIVTATSVAACLFFEWAIVKFLMKKPATTICDGSAVITGVLLAFNLPSNLPIWIIILGA
                     LFAIGVGKMSFGGLGCNPFNPALAGRVFLLLSFPVQMTTWPVVGQLTSYMDATTGATPL
                     ALMKQAIHGDASALSQIPDALTLFIGQNGGCIGEVSALALLLGLVYMLWKKIITWHIPV
                     SIIVTVFVFAGIMHMVDPEKYVSPVLQLLSGGLMLGAVFMATDYVTSPMSKKGMLIYGV
                     CIGLLTVVIRLFGAYPEGMSFAILIMNAFTPLINTYCKPKRFGEVAKKK"
     CDS             complement(12907..14244)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Complex1_51K"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: SLBB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: RnfC_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_10"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg460_43"
                     /sec_met_domain="Fer4_10 (E-value: 4.4e-09, bitscore: 28.0,
                     seeds: 59, tool: rule-based-clusters)"
                     /sec_met_domain="SLBB (E-value: 2.6e-16, bitscore: 50.9,
                     seeds: 67, tool: rule-based-clusters)"
                     /sec_met_domain="Complex1_51K (E-value: 9.2e-51, bitscore:
                     163.3, seeds: 88, tool: rule-based-clusters)"
                     /sec_met_domain="RnfC_N (E-value: 5.8e-30, bitscore: 94.9,
                     seeds: 53, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 9e-06, bitscore: 17.7,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKTFSIGGVHPHENKLSAHQPIITAEVPAKAVILLGQHIGAPAK
                     PIVAKGDMVKVGTKIAEPAGFVSAAIHSSVSGKVAKIDTVVDASGYAKPAIFIDVEGDE
                     WEEAIDRSKTLVKECELSSEEIVKKIADAGIVGLGGACFPTQVKLCPPPSFKAECVIIN
                     AVECEPYLTADHQLMLEHAEEVMVGVSILMKAVKVNKAFIGIENNKPDAIELMTKVASS
                     YAGIEVVPLKVKYPQGGEKQLIDAITKRQVASGALPISTGAVVQNVGTAFAVYEAVQKN
                     KPLFERVITVTGKSVAKPSNFLARIGTPMKQLIDACGGLPEDTGKVIGGGPMMGKALVN
                     IEVPTAKGSSGILIMNQKEAKRGEAQTCIRCAKCVSACPMGLEPYLLGALSENGDFETM
                     EKERIMDCIECGSCQFTCPANRPLLDYCRLGKGKVGAMIRARQAKK"
     CDS             complement(14269..15150)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Fer4"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: FeS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_17"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1016:4Fe-4S dicluster domain (Score: 38.6; E-value:
                     4e-12)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg460_44"
                     /sec_met_domain="Fer4_7 (E-value: 2.9e-12, bitscore: 38.6,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 9.8e-09, bitscore: 26.4,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_2 (E-value: 2e-08, bitscore: 25.6,
                     seeds: 214, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 9.6e-09, bitscore: 26.7,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_17 (E-value: 3.4e-08, bitscore: 25.6,
                     seeds: 82, tool: rule-based-clusters)"
                     /sec_met_domain="FeS (E-value: 8.5e-11, bitscore: 33.0,
                     seeds: 364, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 1.1e-05, bitscore: 17.4,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLILIAVISLGAIALVLAAILYVASKKFAVYEDPRIAQVGEVLP
                     QANCGGCGYPGCSGFADACVKAGSLDGKFCPVGGQPVMAQIADILGLAATEAEPMVAVV
                     RCNGSCANRPRINQYDGAKSCAIAASLYGGETGCSYGCLGCGDCVAACQFDAIHMNPET
                     GLPEVDEAKCTACGACVKACPKAIIEIRPQGKKSRRVYISCVNKDKGAVARKACTVSCI
                     GCGKCVKTCPFEAITLENNLAYIDPNKCKSCRKCVEVCPQNTIIELNFPPRKPKAEEAP
                     KTVAAEAPKVTE"
     CDS             complement(15157..15582)
                     /locus_tag="ctg460_45"
                     /transl_table=11
                     /translation="MTNNTIKHLGIVENIQGSHLSVRIVQTSACAACSAKGHCSSADSK
                     DKIIDITDVTAASYQVGERVMVIGETSMGMMAVTLAFIIPFVLLIVSLFAWMALIGNEL
                     YAALLSLAVLIPYYFVLWLNKTRMKQHFSFTIKPINN"
ORIGIN
        1 gcataacaag tatttatatc ttcctttaat gtagcgattt taaaggcatc actctcgtgc
       61 ttctgattag aatcatattg caaatcagtt aacactttaa gaagtttttg ctgtttttta
      121 ttttgcataa aataaagaca tgtcgtccca atacaacata atactgaggc tatgataact
      181 atatttttca tttttgccat tatttgtttt agaaacaaga aaccgtgcaa agttttcaat
      241 actgaatagg aaaactttgc aaacggtttc aatgattact ttttcatttt ttgtatcagt
      301 ataatcgggt tggattcact tccgtctgtt ttagccagtt ttaggaattt ttgccgcaac
      361 tcttctgtat agaaatgtgt atcatttgac tctaattgtt ctagtgtacc tgggaaattc
      421 caataatctg cattatagca ttgaattatt cgttcatcct gaataatgac ccctgcgtca
      481 tttgattgaa tttgtaaatt tcccagtttt acattttgca aatgtttcgt cgtatgaatt
      541 tcaccagttt ctttattata tatagctata tagttatttt cagaatcccc aaattgtaaa
      601 aacacatact tatttgactg taaaattcta tctattcccg ttacataatt atcacggata
      661 gcagtccgaa gagctatagt tccatcccct tcaataaatt gcttaggaag acgtctatct
      721 ccaaaatcta ttttatacaa aagagagatt tcctcatctt ttatcatgta taactcatca
      781 taaggaaaga aacacaataa tgcctcattt cctaattgag cataagaaac ctcaccaaac
      841 ccttgattgt ttttgggttc gtcaaaagga aaaaactttt ctattttatc agagctattg
      901 agatcaatgg taaaaagttt atagaacccc tccttagtat tactagaatt aggcaaataa
      961 agtttatcat tcatacagaa taattcttcg gcccaaatat tacctatacc tttatcacgt
     1021 ataaatttac cggatgcatc ataaaataaa aatttcccca tgtaatggtc aaataatatc
     1081 acgtcagttc catgcactgt aaaataagat atatttgtat attcacccgg accacttccg
     1141 acggaatgga ttttagtcct caatttacca gacatatcaa agacaaatat acttttacta
     1201 atattatctg cgatataaat taaattgttc aggcaaatga gttttgtaat ttctccaatt
     1261 aagcaactgt cattagtctc tagatggaac attaaaacgc tatcctctac cattggagaa
     1321 taatctataa cattgcttac atgcttccaa tctattttca acaaattagc atcagaattt
     1381 aatttttttt ccaccttgct agtacagctt gataatataa ttatcaataa caaaagaata
     1441 cacttttctg catttctcat ggcattatca aactaattaa tttgtcgttt ggcaggtata
     1501 tgctgtacaa ccattaccat ctctagggca tttatctctc attccctctg ttttacttga
     1561 cacccaatct ccccctaatg aagcctcttt ctctgtgtac acaattcgac cacttatatg
     1621 tacattacga tataatatac aattatcagg tttacccctc agagtctcat aaaagaattt
     1681 accagagcca tgatcattac tttcttgatc ttctccatca ccattctcac taagagcatc
     1741 aatagaagtc attgttaaat catagacatg atttgcctct aatacagtga taacattaaa
     1801 tacagctaca gcacttatca taagagcagc aacaacataa atcattttct ttttcatttt
     1861 cgtgaaattt taattagtta gtaattggtt atttagtaat gaattcattt ccatacgcat
     1921 ttcatgtatc gccttagagt caacttttgg ctctttggat aacacaatat ttatcatctc
     1981 tttcatttcc gtttcatgga agaaagatgg ttctgcataa agtttagcca ataaatagta
     2041 aggataaata cggattggca gcagttgtgt agatacttta tagcatttct ctgcatcaac
     2101 aaagtttcct gatgcttgat agcattgtcc tagcaggttg taaatattag gatgacaact
     2161 tactaagtta gctcttttca aaacagtaat tgcttcatcg tatctttttt gagcaaacaa
     2221 actgtttgcg tatttcatca agaaattaaa gttatgctta aaggagtcat ataatctact
     2281 atatcccgtt gaagcctcct tttccaaagc ctgatcctgt aacaccttta tgtaatataa
     2341 acgttcagaa agttcattta cattccgtac ttcatagata caaagtacat tgccgccaat
     2401 agagcaaccg gtagcaataa agcatgtatg cactgaaatc caaaatttct caccctttca
     2461 aaatcagaca cacaaatgga gagtagcaat gtacccaaca tcagaaatgg aagaatttga
     2521 aaaggataag atgataacga aaaaatcaat aaagagataa gaccggaaca agcaatagtt
     2581 tctttattgg caattccctt gccaatcccc caaacaatca atgataaaaa caacattaac
     2641 aaaataatgc cgccttcaac gcatatctgc aaaaattcat tgaaagcata ttcgggtgct
     2701 cccgccactc tctcttcctg ttccgtataa ttgcccgatg caaaataggc agattgcttc
     2761 tcaccataca cttgcgagaa agctcccgga ccatatccaa agaatggttt gtctgcaata
     2821 accttgcatg tcgttttcca tataaataat ctaccattag ctgaatctgc tttcatctgg
     2881 aaaagtagaa ctgatgcaca tgccacgatc atcgtgacta atacacaaca taaaaaagct
     2941 atgtagcgat gaacccgtaa gtaatgtttt gcttttatta tccacttgaa atgtatagcc
     3001 aatacccata gactactaaa taacaaagct aaccatgccg aacgactcat cccggcaggc
     3061 aggatgcaca gcatcaaaga aaaagcaact agccacaggt atcgtacttt tccggtagat
     3121 tcgagtaaac aacctaaacc aataggaaaa atcatagcta aatagcctga atagggcccg
     3181 ggattataaa aaggaccggt tattgcaaat aatacgtgat tagagggtag aaatccatga
     3241 agttgcaata ctccccatag agatagtatg caacctatag ctacaatccc cccatagaga
     3301 atggtccttg acatagctac atttgtcaat agaatccgtg atgcatacca taatatcaat
     3361 aacaatatag catatattat tttccagtca gctaattgga gctcataatc gtatcgggcg
     3421 atatagtaaa cgaccaaaat agaaatgagc atatccggaa cagatatccg gaagcgtctg
     3481 tttctcgcca taaatgaaaa gaaagccacc actgaaacca aacatattcc aagagagatt
     3541 ggaaaaagca gcaaataatt atcataaata ctatacctaa caaaaaatgc gctacaaagc
     3601 attacgctaa atatgacagt tattagtatt gataagaata cagacttttt gttgtttttc
     3661 attgtgtgtt atgaatatta ataatgctta tctatttcat attatttatc gcattgcgca
     3721 aacagtgctg cactgtgctg ttgcataatc gtgctaatcc tttagattac agagtcaatt
     3781 accactccga tctgccaacg aaggtacagg aaaaaagata atagcatgca taaaacatcg
     3841 gctaatttcg gctctacagg ttgatttagt gatttttgaa aacatattag tgatttttga
     3901 aaatcgcagc acaccttatg ccgcattctc actcatcgca ttttccatat cagagtaaat
     3961 acatatattt ccactaccta ttcattgttt agttactaat gcggaaagat tctccctact
     4021 tatgtctgat gtgaaaaagg attcgagtag taatacttat attattgctt cagtttccct
     4081 cttaaaaaaa taaataatgt agttttcatt ctagtatgtt ttagatgttt atcatagtca
     4141 cttgctatat ttttttaaag attctgttcc atcttatctg cttcgtcttc tggtctcttg
     4201 aaaaccaaat aatctgtccc actcctaaaa tgaaatcatc gggtaatatt ccccaataac
     4261 gagagtcata cgaatcattt gtgttatctc cgcacataaa ataataatcg tgctgaaagc
     4321 agtatactcc taacaatgta tctgcaaggt atacctgtcc cgcctcatcc atcctcatca
     4381 aagattcagt ctcatattca atgcacttac ggtaatcatt ataattaatg gaatcaatcc
     4441 gaatgctatc ccctatttca ggtaaataaa cgctcctcca ttcgtcattg accatccact
     4501 gataagtctc tccgggaact gcagcacaac gtttacaata aaagacatca tcacctatga
     4561 tcatcttttc cttattttct gcataaggga aattgaatac taccacatcc ttcttctgta
     4621 ctctgcggac tccttctttc cgatgaatca aataatgtcc cggatgggtc gcatcttctt
     4681 cccaaattct acgtccaggt atctgcatag aagcgaaaat gtaatcaccg ccaaccaaag
     4741 taggagacat tgaataggta ggtatagcgc aagataccaa ccagtatatt ctgactgaca
     4801 gatacacttg aaacaataca aatagactaa aaaatagata tcccagcctt ttcaataatt
     4861 ttcgcattct cttattcatg ccttttactt tttttgctac tattccattt cataatacaa
     4921 tagtacggga ttagaatccg cagataaaga tttcagtcgt tggagatcag aagaagacaa
     4981 aagagtttca tttcttgata ccagctccac aaatcgctcc atttccattg gatgtatata
     5041 tgaattttcg tttcatcttg aattatatta atcacatatc gttatttaaa tccatctaaa
     5101 ctctgaatac atctccatca tctgccagta aaggtagtag ataaggaatt ggtaggggca
     5161 gaaagttgca aatagttttg agcagaatag cagaattagt gatttttgaa aactttgcag
     5221 cgatttttga aagtcgaacg tcacattttt atagctttta taatcaagaa tgtataattg
     5281 agattctctg aaaaaaataa ccttcttaaa aaaaggaata tttaaacggt ccaggaagag
     5341 ctaaatcgca tcaactctac agaaggataa gagaaactcc agcatttgca agcaagggat
     5401 tctttctttt tattattggg ggattttatt gattaaatag attctatttt tcatctttgc
     5461 ttatcattct gcaaatcaaa gtagcaatag atataacatt ttattgttca cctctttttt
     5521 tatatttata ataatctaga agaaaacaag cgttaaacag cttctttatg tcttctttac
     5581 cacagataaa aaggttcgtc ggtgaggaag gagaccttgg ttttaaagga acacctcctt
     5641 ggttttaaac caaggaagac tttcagagca aaaaaagatg gatatttata gatgttttta
     5701 tacaatataa gcctatattc ctgcatatta ttacgctatt ttatgcattt ttttgctggt
     5761 tcatcatttt cggaacaaca attattctgc ttaatcttaa aaatagcaca tcaaggctag
     5821 aaaataaata atgatcagta tgcttcattt taggatagtg acagatttgt taaataaaga
     5881 tctataaacg tccgcttttt agaaaggcaa cggcccttcc gttgcaccga acggattatt
     5941 tccctgcgga acaaagtccg gttccggcgg aggcggagcc atagcaccgg cattcagttt
     6001 agaccccagc atagcacctg caggttcacc cggcatcggt ataaccatat catcttccgg
     6061 attagagaat cgtgtaaact cacctttgaa tcggagcaag acttcaccta ctgcaccatt
     6121 acgatgcttg gctatcacaa tttccgccat accgcgcagg tcgttaccac gatcatcctg
     6181 ataaatctta taatattccg gacggtgaat aaaacacacc atatcggcat cctgctcgat
     6241 ggctccggat tcacgaaggt cactcaactg agggcgttta ccgtcaatac cttcacgact
     6301 ctccacacca cgattcaact gcgacaaggc tataatggga atgttcaact ccttcgccaa
     6361 tcctttcaac gaacgggata tcgtactaac ctcttcctga cggctaccga atgccatacc
     6421 actcgcattc atcaattgaa ggtagtcaat aataatgatt ctcaccccat gttcacgcac
     6481 cagacgacgt gctttggtcc ggagttcaaa cacagacaaa gacggagtat cgtccacata
     6541 aagcggagca tccagcaggt ctttcagttt gtagtccaac tgttgccact catagcttgc
     6601 caattgtcca cttttgatct tctcactcgg aatctcacaa acattggtga taagacggtt
     6661 gaccaactgg acgttactca tttcaagaga gaacaacgct accggattcc gataatcaac
     6721 agcaatattc ttagccatag aaagtacgaa agctgtctta cccatggcag gacgggcagc
     6781 gattataata aggtcggagt tctgccaacc ggaggtcatc ttgtccagtt tcgtaaatcc
     6841 actttcaaga ccactcagac cgtccgttcg tgcagccgct ttctgaatca gcttatacgc
     6901 ttcgtcaatt accggattaa tctgcgtata gtctttcttc atattctgct gggaaatctc
     6961 aaacagcttg ccttccgcct cctgcatcaa gtcgtccaca tccagtgtct catcaaaagc
     7021 cttgctttga atattactgg taaacgttat caattcgcgc gccaacgatt tttgtgcaat
     7081 aatacgggcg tgatattcga tatgtgcgga agaagcaacc ttactgctca actgagtaat
     7141 atagaacggt ccaccgacct cttccaactc acctcttttg ctcaactgct ctttgaccgt
     7201 cagaatgtcc accggcttct gattaacggc aagatcagta atggcagcat aaatcaactg
     7261 atgacgatgc tcataaaatg actccgggcg aagaatctca ctcaccagcg aataagcatc
     7321 cttctcaatc attaaagcac ccaacaccgc ctcttccagc tccggtgcct gaggttggat
     7381 acgaccataa tcattgaccg gttgtacttt agttgatttt gtgttacggg aatttcttct
     7441 ttgttcagcc atctgcttat atacaatttt atgatttaca atttatgatc cccggctttt
     7501 atacatagta aaagccgaaa gggatgacaa agatagaata taataatgaa gaaaagataa
     7561 ggaaaaatga agattttagt aactttgtca ccaatagcat aaattcgcaa cccataattt
     7621 aaaattcaaa aataataatt cagaacgaat atgatcactt tcccaaacgc aaaaataaac
     7681 ctgggactct ctattaccga gaagcgtccg gacggatatc acaacctcga aaccgtattc
     7741 taccccgtcg ctctcgaaga tgcgctggaa atccggacca gccccgaagc ggacaaaaag
     7801 ttctccctgc atcagtacgg aatggagata tccggtaatc cggaagacaa tttagtggtg
     7861 aaagcatatc tgctattaga taaagagttt cacctctctc ctatcgagat ccatctgtac
     7921 aaacacattc cttccggtgc cggactggga ggaggctcat cagacgcggc tttcatgctg
     7981 aaattactca acgaacactt tcagctgaat ttatccgaag atcagctgga aatatatgcc
     8041 gcaactttgg gagcagactg cgctttcttt atcagaaacg ccccgacctt tgccgaagga
     8101 atcggcaaca tattctcccc cattccacta tccttaaaag gatatcagat tctgatcatc
     8161 aaaccggatg tattcgtatc aacgcgggaa gctttcgcca atattcatcc tcatcatccc
     8221 gaatactcga tcaaagaagc gatcaaacgc ccggcaaatg aatggaaaga gatattaatc
     8281 aatgattttg aagacagcgt attcccccag catccggtga tcggagaaat taaagccgaa
     8341 ctatacaggc aaggggctgt ttatgcctct atgagcggtt ccggttcttc cgtatatgga
     8401 ttgttcgagc cggaaggaac tttacctgaa accgattggg gaactaacgt attccgtttt
     8461 aaaggcaggc tgtaaaggag taacaaaaaa cggtaccacg actcccgtcg tagtaccgtc
     8521 acaacacaaa cacaaaataa aacacgacaa aactactatg caatcatacc tgtctatgcc
     8581 ggagaggcat aagtaccatt tactcatatt cacatactca caaacagatc aagctgatta
     8641 gcatctaata aacaaatcgc atgaacgatt tgtttaaact tttatgttaa ttaaaacaaa
     8701 tatcttttta ctgaatgcct ctttcacgga gtttcagctg ccaattccat gcagagcgta
     8761 aagtatcttc taatgtttct accgctttcc aacccagttc ctggttggca aaatcggggt
     8821 tagcccatac cttttcaata tcacctgcgc gacggcctac aatctgataa ttcagtttaa
     8881 cgccagtagc tttttcaaag ccattaatca gttccaatac tgaaacaccg cgtcctgtac
     8941 cgatattgaa tacttctact ttttctttct gtttttgctc caaaatacgg cggattgcaa
     9001 tcacatgtgc tttagccaag tcaacaacat tgataaagtc acggatacaa gaaccgtcag
     9061 gagtatcata atcgtcaccg aatacactta gtttttcacg gatacccatc gctgtctgag
     9121 tcagataagg aatcaggttt tgaggaacac cgttcggaag ttcacccaac aatgctgtag
     9181 gatgtgcgcc aatcggattg aaataacgca gcaaaatagc attgatcggg gcaccggaag
     9241 ctattgtatc acggataatt tcttcattaa tctgttttgt atttccataa ggagattccg
     9301 ctttcttgat cggagccttt tccgttacag gcaactcatc cggttgacca tatactgtac
     9361 aggaagaaga gaacactatg ccttctactc catgtttagg cattaactcc agaaggttga
     9421 ttaaagaaac caggttgtta cgataataaa gcaacggctt ctctaccgac tctcctactg
     9481 ctttgcttgc tgcgaaatga ataatcgctt taattccttt atatttggca aatacggcat
     9541 caaggccagc aaaatcaaga caatccagtt tctcaaaagc tgggcggata ccggatactt
     9601 tctctatatt gtcaacaacg tcagcactcg aatttgataa attatcgata atgattactt
     9661 cgtatccact gttttgtagt tctacaacgg tatgagaccc aatatagcct gttcctcccg
     9721 ttactaaaat tctttctttc atataatttt aaaatatggt tagtttttcg gttttcagtt
     9781 tgtttgaggt acaaatgtat ggaaataaaa tggaaatgca ataaactatc gcaattttat
     9841 tcacaggaag atacttacgg gacgatttga gggcgttttg gtatgataaa aaacatattc
     9901 ggtatgaaca gatataaaga aaaaggccgg aaacaaactg cctgtatgtt gccatacgac
     9961 agagtttcca gcctctttat ctaattatca acttagtctt ttacacgacg ccagagaagc
    10021 ccatgaatgc cattgccagc aaacctgcgg taatcaaagc aatcggagtc ccctgcattc
    10081 ctttcggaat cttcaccagg gtcatctgct cacgcaatcc ggcaaacaat accagtgcca
    10141 gaccaaagcc aagagcagta gagaatgcgt atacaacacc tgtcagcaga tcaaagtctt
    10201 tctggattac caggattgcc acaccgagaa tacagcagtt cgttgtaatc aacggcagga
    10261 acacccccag tgcctgatac aaagaaggag aaactttctt cagaataatt tctaccatct
    10321 gcaccagtcc ggcaataacc agaataaaag tgattgtctg taagtacccc aatccgaaag
    10381 cgtccaacac aaacttctga atcaggaatg tgacgatggt agcgatagtc agcacgaaag
    10441 caactgccgc actcataccc atcgctgttt ccaccttctt ggaaacaccc aggaacggac
    10501 agattcccag gaactgcgac aacacaatgt tgtttacaaa gattgccgag ataaatatca
    10561 atatatattc catattcttt tcttatttaa tagagttagg ctttcttcag actattaata
    10621 atggcaatca gataacctaa agcgataaag gcacccggag ccagaacaaa gatcagcatt
    10681 ccgtattctt ccggcagaat ggtcagattg aatatcttac ctgttccgag gaattcacgt
    10741 acggcaccca acagagtcag ggcaatggta aaaccaaatc ccataccgat accatcaaac
    10801 atagaagcca gcggattgtt cttcgctgcg aaagcttccg cacgtcccaa tacgatacag
    10861 tttactacga tcagcggaat gaaaagcccg agagtagcat acagatcggg cacgtatgct
    10921 tgcattatca tctgcaacag tgtcacgaat gacgcgatca ccacgataaa tgaagggatg
    10981 cgtaccatat ccggaatcag attcttgata gatgaaatta ccacgttcga gcaaatcagg
    11041 acgaacatag tggccagtcc catacccata ccgttgattg ccgatgatgt cgtacccagt
    11101 gtaggacaca taccgagcag gagcacaaaa ataggattct ctttgataac cccgttcatc
    11161 attactttaa aattattcat aactgtctcc tcctttctta gttattagtg tcattagcag
    11221 ctgcttcacc ttccggtgca acagccggtt catttttctg ggaagctccg gaattcgtat
    11281 ccacctcacc gcctttatat gcctgataag cagcattcac cgcattcagg aaagcacgtg
    11341 aagtgatagt agaagccgtg atagcatcta cctgtccatt catgtctttg gtcacagcca
    11401 atggagtctc tcccggattc atgcccaaaa tagactttgc actttcttcg tgagataccg
    11461 gtttttcgtt ctttgcagga tcataagctc caaaccattt gtccgctttc gaacccaatc
    11521 ccggagtttc agcgtgcgcc aataaagagt agttataaat cttgccttca gcatcaaagc
    11581 ccaccagcac tttcagttca ccgccaaatc ccattgactt ggcttcaacg gcagaaccta
    11641 cccacttttc gccattcttg gccggataga taatgaaatc cacgattttc tttccgtctt
    11701 tctcgctgaa aacagtatcg ctttcggcta ccggattatt ggtatattca ggaagcacct
    11761 ttttcaaggc ctcgttcagc gtctttgcat tcgcttcggc aatagggcct ttcgtcagtt
    11821 cgttcacata agccagcaac gctacggaaa cggctgtaac gcccgtaagt accagcaaca
    11881 tattctttaa agatgattgt aactttttca tttcttcttc gctacctccc caaagcgttt
    11941 aggtttacaa taggtgttaa tcagcggagt gaacgcattc ataatcagga tggcgaatga
    12001 cataccttcg ggatatgcac cgaacagacg gataaccacc gtcagcagac cgatacaaac
    12061 accgtaaatc agcatacctt tcttgctcat cggagaagtc acatagtcgg ttgccataaa
    12121 gacagctccc agcatcagac ctccggagag tagttgcaat accggagaaa catacttttc
    12181 gggatccacc atgtgcataa tgcctgcaaa tacaaataca gtcacaatga tagaaaccgg
    12241 aatatgccag gtgatgatct ttttccagag catgtatacc agtccgagca acagtgccag
    12301 cgcacttact tcaccgatac atccgccgtt ctgtccgata aacagagtca gcgcatcagg
    12361 tatctggctc aaagcacttg catcgccgtg aatagcctgt ttcatcaatg ccagcggagt
    12421 agcaccggtg gtagcgtcca tataagatgt cagctgacct actaccggcc atgttgtcat
    12481 ctgcaccggg aaagaaagca acaggaatac acgtcccgcc aatgccgggt tgaatgggtt
    12541 gcagcccaga ccaccgaaag acatcttgcc tacaccgatt gcgaacagtg cacccagaat
    12601 gataatccag ataggcagat tggaaggtag attgaatgcc agcaacacac ctgtaatgac
    12661 agcagaaccg tcacagatgg ttgtagcagg tttcttcatt aagaatttaa cgatcgccca
    12721 ttcgaagaat aaacaggctg ctaccgaagt agccgtgaca atcagagccc ccaggccgaa
    12781 gaaataaagc gacaccagaa aagccggaat cagtgcgatc agcacgccat acatattttt
    12841 ctgtacgctg tctccgccat gcacgtgggg tgatagtgat acgattaatt tattttccat
    12901 acttcgttat tttttagctt gacgtgcacg aatcatagct cctactttac ccttacccaa
    12961 gcggcagtaa tcaagcagcg gacggttggc aggacaagtg aactgacagg aaccgcactc
    13021 gatacaatcc atgattcttt ctttttccat tgtttcaaaa tctccgtttt cggacaaagc
    13081 tccgagcaag tacggctcca gtcccatcgg acaagcgctc acacactttg cgcaacggat
    13141 acaggtttgt gcttcaccac gtttggcttc cttctgattc ataatcagga tgccggaact
    13201 gccttttgcg gtaggaactt cgatattcac cagagcctta cccatcatcg gaccgccacc
    13261 gatcactttt cccgtatcct ccggcagacc gccacaagca tcaatcagct gtttcatcgg
    13321 tgtaccgata cgcgccagga agttggaagg tttggccaca gacttaccag ttacggtaat
    13381 cacacgctca aacaacggtt tatttttctg aacagcttca taaacagcaa atgccgtacc
    13441 cacattctgc acaactgccc cagtagagat aggcagcgca ccacttgcca cctggcgttt
    13501 ggtaatcgca tcaatcaact gtttctcacc gccctgagga tatttcactt tcaaaggaac
    13561 aacttcgatg cctgcataac tggaagcaac tttcgtcatc agttcaatag catccggctt
    13621 gttattctca attccgataa atgccttatt taccttcacg gctttcatca gaatggagac
    13681 acctaccatt acttcttccg cgtgttccag catcagctga tggtcggcag tcagatacgg
    13741 ttcacattcc accgcattga taatcacaca ttctgccttg aacgaaggag gcggacaaag
    13801 tttcacctgt gtagggaaac aagcaccacc caaacctacg ataccggcat cggcaatctt
    13861 cttcacgatt tcttcggacg aaagctcaca ttctttgacc agtgtcttgc tacggtcaat
    13921 ggcttcttcc cattcatcgc cttctacatc aataaagata gcaggttttg cataaccgct
    13981 cgcatcgact actgtatcaa tcttcgccac ttttccactg acagaagagt gaattgctgc
    14041 cgaaacgaag ccggcaggtt cggcaatctt cgtgcctacc ttcaccatat caccttttgc
    14101 tactatcggt ttggcaggtg cgccaatgtg ctgccccaac agaataactg cctttgcagg
    14161 aacttccgct gtgatgatag gttgatgtgc cgacaattta ttttcgtgtg gatgaactcc
    14221 accaattgaa aatgtcttta acatacaatt ctgtatttta ttctgttatt attctgttac
    14281 cttcggagct tctgcagcaa ctgttttcgg tgcttcttcc gccttcggtt tacgtggagg
    14341 gaagttcagc tcgataattg tgttctgcgg acaaacttcc acgcacttac gacatgattt
    14401 acacttgttc ggatcgatgt aagccaggtt gttctccagc gtaatggctt cgaacggaca
    14461 agtcttgaca cacttaccac agccgataca gctcactgta caagccttac gtgctacggc
    14521 tcccttgtct ttgttcacac aagagatgta cacacggcgt gatttcttgc cttgcggacg
    14581 aatctcaatg atcgccttcg gacaagcctt cacacaagcg ccacaagctg tacatttggc
    14641 ttcatccact tccggaagtc ccgtttcggg attcatgtgg atagcgtcga actggcaggc
    14701 agccacacag tcgccacatc cgaggcatcc gtagctacaa cctgtttctc caccatacaa
    14761 tgaagcggca atagcgcaac tcttcgcacc gtcgtattga ttaatacgcg gacggttggc
    14821 acagcttccg ttacatctca ctactgctac catcggttca gcttcagtag ctgccagtcc
    14881 gagaatatca gcaatttgtg ccatgacagg ctgaccgcct acagggcaga atttaccatc
    14941 cagcgaaccg gctttgacgc aagcatcggc aaatccgcta caaccaggat agccacatcc
    15001 accacagttt gcctggggca acacttcccc cacctgggca atccgcgggt cttcatacac
    15061 ggcaaatttc ttggaagcta cataaagaat agcggccagc acgagcgcta tagctcccaa
    15121 tgaaatcact gcaatcagaa tcaaattcat aatgttttag ttatttattg gttttatagt
    15181 aaatgaaaaa tgttgtttca ttcgcgtttt attgagccac aatacgaaat aataaggaat
    15241 aagaactgcc agagaaagaa gagccgcata cagttcattc cctatcaacg ccatccatgc
    15301 gaacagggaa acaatcagaa gtacaaaagg aattatgaat gcaagggtta cagccatcat
    15361 gcccatcgac gtttcgccga tcaccatcac ccgctctcct acctgatagg aagcagctgt
    15421 aacatccgtt atatctatga ttttgtcttt actatccgcc gaagaacagt gtccttttgc
    15481 gctacaagcc gcacaagccg acgtctgaac gattctcacc gacagatgag aaccctgtat
    15541 gttttccaca atacctagat gctttatagt attattcgtc attttgcaaa ctcaacatta
    15601 caaatcgcgg caaatttaat cattattt
//
