LOCUS       gnlProkkaHHLPGKMA_99   12380 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HHLPGKMA_99.
ACCESSION   gnlProkkaHHLPGKMA_99
VERSION     gnlProkkaHHLPGKMA_99
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 18:24:42
            Original ID  :: gnl|Prokka|HHLPGKMA_99
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12380
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12380
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[6544:6892]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      6545..6892
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..12380
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12380
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(2..1543)
                     /locus_tag="ctg99_1"
                     /transl_table=11
                     /translation="MSSLKGHPKGLYLIFATSTAERFSYYGMRAIFILFLTQALLFDKE
                     AAASIYGSYTGLVYLTPLIGGYIADKYWGIRRSVFWGAVMMAVGQFLMFMSASSLNNTD
                     LAHWLMYGGLGFMILGNGCFKPTVSSLVGQLYEPGDKRLDAAYTIFYMGVNVGSFAAPL
                     ICGFLGDTGNPQDFKWGFLASGIMTLFTVVLFETQKNKYLFSPSGEPIGIVPDARREKK
                     EDKAEHISHPKMDKRIKVRNIIIITALTVVLIAFFSYAFSDDWISVGIFTACIVFPVLI
                     LLDGSLTKVERSRIFVIYIVAFFVIFFWAAYEQAGASLTLFASEQTDRSIFGWEMPASW
                     FQSFNPLFVVILAYIMPGIWGFLNKRNMEPASPTKQAIGLLLLSLGYLFICFGVKDAIP
                     GVKVSMIWLTGLYFIHTMGEIALSPIGLSMVNKLSPLRFASLMMGIWYLSTATANKFAG
                     MLSGLYPEDGKVKSILGYQIATMYDFFMLFVIMSGVASLILFLLSKKLQKMMHGVE"
     CDS             complement(1736..1960)
                     /locus_tag="ctg99_2"
                     /transl_table=11
                     /translation="MMEKKRIGSNAGKVWRILNEKGEQSMFTLCHELGLTFEDVAIAIG
                     WLARENKILLRKKEGMLYASIENVEFTFG"
     CDS             2233..3066
                     /locus_tag="ctg99_3"
                     /transl_table=11
                     /translation="MTTKKLTGILSLFLCIICLVSCNDNDDNFSPITLEYEDPQIKFDN
                     ESRSYTLTPFSKETTPLFIKGGDGTYKVTNENEKVVQVNYHNGSLTLKAKEIGRASIKI
                     EDSSNNMYILSVVVKYRTLTHKAFTAKVIVKGDELTVKEHTELMNKVGNSYPINKYVFT
                     FMNAEDSKGTIDLYYSDNNMKTGNFEKEHIVLDEENAIPIKGEYKLSEYYRITIKEDNG
                     KVIDTFYITKNFLPLLNTRMNAHPLIQYCFVRDLTAQYKQDYLALENAYLIQIAE"
     CDS             3598..5109
                     /locus_tag="ctg99_4"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIEHEPIASIDLMERAAQALTKAITNRWNP
                     ETPVTIFAGPGNNGGDALAIARMMAEKGYKIEVYLFNTKGELSPDCQTNKELVEMMEEV
                     TFHEISTQFVPPTLTPEHLVIDGLFGSGLNKPLSGGFAAVVKYINASPAMVVSIDIPSG
                     LMGEENTFNVKSNIIRADVTFSLQLPKLAFLFAENTEFVGEWELLDIQLSEEGIEETET
                     NYEMLEIEEIRSLIKPRQQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPLCNNDILQTSAPEAMVETDVSETCFAVPTDTDDYQAVGIGPGLGRSEETEAALIEQ
                     LEHCQTPTVLDADALNILANHRHTLTHLPKGSILTPHPKELERLVGKCQDSYERLMKAC
                     ELAHTAKVHIILKGAYSAIITPEGKCYFNQTGNPGMATGGSGDVLTGVILALLAQGYPA
                     EDAAKIGTYIHGLAGDIAQKKQGMIGLIASDIVTCLPTAWRLVSE"
     CDS             5183..6247
                     /locus_tag="ctg99_5"
                     /transl_table=11
                     /translation="MKKFIIATGLLMATSAYAQTEVLTGVTRGKDYGVVYALPKTQIEI
                     EIKANKVNYKPGEFSKYADRYLRLTNVSAEPEEYWELNSVKVKPVGVPNSEATYFVKLK
                     DKTVAPLMELTEEGLIKSINVPYSSNNAKNAANNAVAPQRKANPRDFLTEEILMASSTA
                     KMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNLQEEAMTEMFSGVRNK
                     EEKTFTVRLTPDKEFDNEVAFRFSKKLGIVANNDLAGTPFYISLKDLKTVKIPQEDGKK
                     KKEMEGIAYNVPGQAMVTLTDGKKKLYEGEIPVTQFGIIEYLAPVLFNKNSTIKVYFDP
                     VTGGLLKVDREESK"
     CDS             6268..6555
                     /locus_tag="ctg99_6"
                     /transl_table=11
                     /translation="MGGEGHMLDMIRRLKDGKEASRLRRERRNDKLGRLRRNNDPYLLP
                     DTTPEEMERIIKDSEKKKEKDNSYFVWGTLIIMGVLIGCAVLLWAIFFNG"
     CDS             complement(6545..6892)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg99_7"
                     /sec_met_domain="PF05402 (E-value: 1.3e-17, bitscore: 53.8,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PqqD_RRE (E-value: 4.7e-10, bitscore:
                     29.0, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATKEKINLLEVIPCRNEHIKAEQEGETIVLSFPRFKRSWMSRYL
                     LPKGMSKDIHVRLEEHGTAVWNLIDGQRTVREIIEKLADHFQYEAGYESRVSTYLSQLQ
                     KDGFIKWIIIH"
     CDS             complement(6937..8325)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 87.3; E-value: 1.3e-26)"
                     /gene_kind="transport"
                     /locus_tag="ctg99_8"
                     /transl_table=11
                     /translation="MTEQLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AITTTFPEGAMLFGFKMQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARNGTTLAMVLTVPLADFFGSTDESGVFHTNIPAPILFCLVMLCVGTIAFFIYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMVIGSVMLIFVHTMFAL
                     PILNIWWFATVIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNSYCKGPVVDGAQTYDYTLPMAIFAMFGVLALIVALMLKVENKKKGYGLEEA
                     NIQK"
     CDS             complement(8616..9011)
                     /locus_tag="ctg99_9"
                     /transl_table=11
                     /translation="MYLLFIILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSVATAYVVPSSSAAKDVLLEQAQKEQQTNPYNMPTGTAAP
                     QTDATAPAESAPATEAPATETPAPAAE"
     CDS             complement(9034..9795)
                     /locus_tag="ctg99_10"
                     /transl_table=11
                     /translation="MTSVNLQQWIQHPETLNRDTLYELRNQLARYPYFQSLRLLYLKNL
                     YILHDINFGAELRKAVLYIADRRKLFHLIEGERFAVESQKKGLPLSEVLKDEPTVDRTL
                     ALIDAFLSTAPEEVTSQTSFDYSMDYTAYLLEETSVADEPAEAMPKLKGHELIDNFIEK
                     SETDPVVYLKPLREEEKAKAASSAETNETGRTDETTETNTIEEEDDSCFTETLAKIYVK
                     QQRYSKALEIIKKLSLKYPKKNAXXXXEIDY"
     CDS             complement(9800..10327)
                     /locus_tag="ctg99_11"
                     /transl_table=11
                     /translation="MNWIKKIARPLILVVLPAVIIACSVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPNQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSSQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             complement(10314..11555)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 388.8; E-value:
                     6.1e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg99_12"
                     /transl_table=11
                     /translation="MTKAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPLPTQARLLRVLESGEFIKVGSSKVQKTDVRIVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFAADFAEKYRMPAIQLTEDAKKI
                     LLAYPWPGNVRQLKNITEQISIIETNREITAAILQTYLPAQNTQRLPALFGTRESKSFE
                     SEREILYSVLFDMRQEVAELKKMVHNMMAERAGQVGQMGQVVATPVVTTTHQPSVPAII
                     HAVQQPSVCPKEDDDDIQDTEEYVEETLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             complement(11679..12380)
                     /locus_tag="ctg99_13"
                     /transl_table=11
                     /translation="MFSFPGHTEYIEERLGDGNKSLMILMKNDFRVALVTTHIPVREIA
                     TTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLGMEEQEIIIPAMKE
                     MEEKGIICYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAMEDGVNYTAGLPVV
                     RTSPAHGTAYDIAGKGLASEDSFRQAIYVAIDVFRNRQREKAARVNPLRKQYYEKRDDS
                     DKLKLDTVDED"
ORIGIN
        1 attctacccc gtgcatcatc ttctgtaatt tcttcgagag aaggaacaga atcagtgagg
       61 caacaccgga cataatgacg aacagcatga agaagtcgta catggtagcg atctgataac
      121 caaggattga tttcactttt ccgtcttcgg gatagaggcc gctcagcata cctgcaaatt
      181 tatttgcggt ggcggtagaa agataccaga tccccatcat caaggaggcg aaacgtaacg
      241 gactcaactt attaaccata gaaagcccga taggtgacag agcgatttct cccattgtat
      301 gaataaagta aagccctgtc agccagatca tgctcacctt tactcctgga atagcatctt
      361 tcactccaaa acagatgaag agataaccaa gagaaagcag caacagaccg attgcctgtt
      421 tggtagggga agccggttcc atgtttcgct tattcagaaa gccccatata ccgggcataa
      481 tataggcaag gatcactaca aaaagcggat tgaatgactg gaaccacgaa gccggcatct
      541 cccagccgaa aatgctgcgg tcagtctgtt cggaagcgaa taatgtcaga gaagctcctg
      601 cctgctcgta agctgcccag aagaaaatga cgaagaaagc tacgatatag attacgaaaa
      661 tacggctacg ttctactttg gtcaatgaac catccagcag aatgagcact ggaaagacaa
      721 tacaagccgt aaagataccc acactaatcc agtcatcgct aaaggcatag ctaaaaaaag
      781 ctattaagac aactgtaagg gcagtaatga tgataatatt acgtactttg atacgtttgt
      841 ccatcttcgg atgtgaaata tgttcggctt tatcctcctt tttttcacgt ctggcgtcgg
      901 ggacgatacc aatcggttca ccggaaggag agaaaaggta tttattcttc tgagtttcaa
      961 agaggacaac agtgaacagc gtcatgattc cggatgcgag gaatccccat ttaaagtcct
     1021 gcggattccc tgtgtctccc aagaaaccgc aaatcaaagg agcagcgaaa gaacctacat
     1081 taacacccat atagaaaatg gtgtatgcag catccaaccg tttgtccccg ggttcatata
     1141 attgcccgac gagcgaagaa acggtaggct taaagcaacc gttacctaaa atcatgaatc
     1201 cgagtccgcc atacatcagc cagtgggcaa ggtctgtatt gttcagtgaa gaggcactca
     1261 taaacatcag gaactgaccg actgccatca tcaccgctcc ccaaaatacc gaacgacgga
     1321 tgccccaata tttatcggca atgtatccgc cgatcaacgg agtcagatag accagtccgg
     1381 tgtagctacc gtagatagag gccgccgctt ctttatcaaa aagcaatgcc tgcgtcagaa
     1441 agaggataaa gatagcacgc ataccgtagt aactgaaacg ttctgccgtg ctcgttgcga
     1501 aaattaggta aaggcctttc gggtgccctt tcaatgaact catgaattat gtgtttagta
     1561 gtttatgggg cgcaaaggta ctaaaaagta gattaaatgc ctcaaaaaag aagattctta
     1621 tggaatagaa aaatacagga tggcgtgcaa gaagtctcag ttacccacct tattatgttt
     1681 tcaacagtgt aaataatcaa gtggatattc tccttaaatg tgggtcagtc cccatttatc
     1741 caaaggtaaa ttcaacattc tcaatactgg catagagcat tccttctttt tttctaagca
     1801 ggattttgtt ttcccttgcc agccagccga tagcaatcgc tacatcctcg aacgtcaaac
     1861 ctaactcatg gcacaaagtg aacatagact gttcgccctt ttcatttaag atgcgccata
     1921 ctttcccggc atttgagcca attcttttct tttccatcat gcaaacttta gaagattaaa
     1981 caatttatat ttataatcta aacattgtga gcacaggaga ataacgtaaa gcacattact
     2041 gcactacaaa gatatcattt ttttcgaaaa aagcaaataa tcaaggcatt agctgctatt
     2101 attagttaca ttctaatcat ttatgccgat ctctgctaaa aaatagcaca aataaagaaa
     2161 cagttcaatt ctttttcata agtttgcaga cgagaactaa actaatatcg cacatttaaa
     2221 actttaatta gcatgactac caaaaaacta acaggaatac tttcgttatt cctttgtatt
     2281 atttgcctcg tgagctgtaa tgacaatgat gacaactttt ctccaatcac tctggaatat
     2341 gaagatcctc aaattaagtt cgacaacgag agccgttctt acacactgac tccgttcagc
     2401 aaagaaacga caccactctt catcaagggt ggagacggaa cttacaaagt gaccaatgag
     2461 aatgagaaag tggtacaagt aaactaccac aacggaagtt taacattgaa ggcaaaggaa
     2521 ataggacgcg catccatcaa gatagaagac agttcgaata atatgtatat actgtctgtc
     2581 gttgtaaaat atcgtactct tactcataag gcgtttacag caaaagtcat tgtgaaggga
     2641 gacgaactca cagttaaaga acatactgag ttaatgaaca aagtgggcaa ttcatatccg
     2701 attaataaat atgtatttac ttttatgaat gcggaagaca gcaaaggaac aatagatttg
     2761 tattattcag ataataacat gaaaacaggc aactttgaaa aagaacatat agtgctggat
     2821 gaagaaaatg ccattcccat caaaggtgaa tacaaattga gtgagtatta ccgtataaca
     2881 atcaaagaag ataatggcaa agttattgat actttctata ttaccaagaa ctttctacca
     2941 ctcctcaata caagaatgaa tgctcatccg ttaattcagt actgttttgt cagagattta
     3001 accgcacagt acaaacaaga ttaccttgca ctggaaaatg catatctgat tcaaatagca
     3061 gaatgagaac tacactgatt ttcttcttta gcagagtgaa tagagtattt attatatgag
     3121 caaactcccc attagattta gcaaaaaaca ataagctatt agctaatcaa gaatatgccc
     3181 atagcatatt tatcacaatc acctcttcca cccttttcct gaacctttga tgaataaggc
     3241 gattgcgggt gaaagaggtg aaccagagga ataaacagta gtagaaacac gcatgggaag
     3301 gttaacaaac agccatgaat gttctccgga gagagtaaaa gtaaatgaga taacaatgct
     3361 tgtcatactg cgttacaagc attgaaagcc atcataacaa gcattgatat ctaccataac
     3421 aatcattaat atctgacttc tcaactatta ataactgaca catcaactat taatacctga
     3481 caactcaagt attaatacct gaagttcctt cccaaaaagc cgaaaaccaa ccggaataaa
     3541 ggattaattc agagtttttg tgtaagtttg tgcgtcgaaa actaaaagaa tatcgcaatg
     3601 aaaatatttc caagcagcag cattaagaag ttagatgcct ataccattga acatgaaccg
     3661 attgcatcca tagatttaat ggaacgtgcc gcacaggcgc tgactaaagc catcaccaac
     3721 agatggaatc cggaaacacc tgtcaccatc tttgccggac cgggcaataa tggcggagac
     3781 gccctcgcca tcgcccgcat gatggcggaa aaaggataca agatcgaagt atatctcttc
     3841 aacacgaaag gcgaactttc gcccgactgt cagaccaaca aagaactggt agagatgatg
     3901 gaagaagtaa ctttccatga aatcagcacc cagttcgtac ctcccacact gacaccggaa
     3961 catctcgtga tcgacggatt attcggttcc ggactcaaca aaccattgag cggaggattc
     4021 gctgccgttg tgaaatatat caatgcctct cccgccatgg tagtctccat cgacatccct
     4081 tccggactga tgggagaaga aaatacattc aatgtaaaaa gcaatattat ccgtgcggac
     4141 gtcactttca gcctgcaact tcctaaactg gccttcctct ttgccgaaaa tacagaattt
     4201 gttggcgaat gggagttatt ggacatccag ctgagcgaag aaggaatcga agagactgaa
     4261 acaaactacg aaatgctgga aatcgaagaa atccgttcgc taatcaaacc acgccaacaa
     4321 ttcgcccata aaggaaactt cggacatgcc ctgctgatag ccggctcaaa aggaatggca
     4381 ggtgcatcgg tactggccgc ccgtgcctgt ctgcgatcgg gagtaggtct gctgaccgta
     4441 cacgcgccgt tatgcaacaa cgatattttg caaacgtccg cccccgaagc catggtagaa
     4501 acggatgtca gcgaaacatg ctttgccgta cctaccgata cggacgatta ccaagctgtc
     4561 ggcatcggtc cgggactcgg tcgcagcgag gaaacggaag ccgccctgat agaacaactg
     4621 gaacattgtc agactccgac ggtactggat gccgacgcac tcaatattct ggccaatcac
     4681 cggcatacgc tcacccatct gccgaaaggt tccatcctca cccctcaccc gaaagagctg
     4741 gaacgcctgg tcggcaaatg tcaggactca tacgaacgac tgatgaaagc ctgcgaactg
     4801 gcgcacactg ccaaagtaca tatcattctg aagggagctt attccgccat tatcaccccc
     4861 gaaggcaaat gttacttcaa ccagaccggt aatcccggta tggcaacagg aggcagcgga
     4921 gatgtactga caggagtaat ccttgcactc cttgcgcaag gctatcccgc cgaagacgcc
     4981 gcaaagatcg gtacttacat tcacggattg gccggagaca tcgcccagaa aaaacagggc
     5041 atgatcggat taatcgcaag tgatatcgtg acttgtctgc cgacggcatg gcgacttgta
     5101 agcgaataaa agttaagaac ttacggttta ttcaataact tcattaactt tgtttttcaa
     5161 aatcagctaa aaagaaccga atatgaaaaa gtttatcata gcaacaggac tactaatggc
     5221 aacttccgcc tatgcgcaga ccgaagtgct gacaggagtg acgcgaggaa aagactacgg
     5281 agtagtgtac gccctcccca aaacccagat agaaatagaa ataaaagcaa acaaagtcaa
     5341 ctataagccg ggtgaattca gcaaatacgc cgaccgctac ctgagactga ccaacgtctc
     5401 tgccgaaccc gaagaatact gggaattgaa cagcgtcaag gtgaaacctg taggtgtacc
     5461 aaacagcgaa gctacttatt tcgtcaaact gaaagacaaa accgtagctc ctcttatgga
     5521 actgactgaa gagggtctta tcaaatcaat caacgtcccc tacagcagca acaatgcaaa
     5581 gaatgcagca aacaatgccg ttgctcccca acgaaaagcc aatccccgcg actttctcac
     5641 agaagaaatt ctgatggcaa gttcaaccgc caagatggcc gaactggtag caaaggaaat
     5701 ctataatatc cgcgaaagta aaaacgcatt attgcgcgga caagcagata atatgccttc
     5761 ggacggcgca cagctcaaaa tcatgctcga caacctgaat cttcaggaag aagccatgac
     5821 cgagatgttt tcgggagtcc gcaataaaga agaaaagaca tttactgtcc gcctcactcc
     5881 ggataaggaa ttcgacaatg aggtagcttt ccgcttttca aagaagctgg gtatagttgc
     5941 caacaacgat ttggcaggca ctccattcta catcagtctg aaagacctga aaacggtgaa
     6001 gattccgcaa gaggacggga aaaagaagaa agagatggaa ggcattgctt ataacgtacc
     6061 gggacaggca atggtgacgc tgacggacgg caaaaagaaa ttgtatgaag gagaaatacc
     6121 tgttactcag ttcggtatca tagaatacct tgctccagta ttattcaaca agaactcgac
     6181 catcaaagtt tactttgatc cggtgaccgg tggactactg aaagtagata gagaagaaag
     6241 caaataaacc tctaaaaaaa caaaacgatg ggtggcgaag gacatatgct cgacatgata
     6301 cgtcggctga aagacggcaa agaagcctcc cgcttacgcc gtgaacggag aaatgacaag
     6361 ttagggcgac ttagaagaaa caacgaccct tatcttctgc cggatacgac tccggaagag
     6421 atggaacgca tcatcaagga ttcggaaaag aaaaaagaaa aagataacag ctatttcgta
     6481 tggggaacgc tcatcattat gggcgtactg ataggatgtg ccgtcctcct gtgggcaatc
     6541 ttttttaatg gataattatc catttaataa atccgtcttt ctgtaattgg gaaagatagg
     6601 tagatacacg agactcgtag cctgcttcat attgaaagtg gtctgcgagt ttttctataa
     6661 tctcacgaac cgtccgctgc ccgtctatca ggttccatac agccgtaccg tgttcttcca
     6721 gacgcacatg aatatctttg gacattcctt tcggcaataa ataacgactc atccacgaac
     6781 gtttaaaacg agggaaggag agcacaatag tctccccttc ctgttcagct ttaatatgtt
     6841 cgttacgaca agggatcacc tccaggaggt ttattttctc tttcgtagcc atatcttttc
     6901 tcttttatat cttttcagat agaatatata ctgtgattat ttctgaatat ttgcttcttc
     6961 cagtccgtag cctttcttct tgttttccac tttcagcatc aaggcaacaa tcagggcaag
     7021 tacaccgaac atagcaaaaa tagccatcgg caaggtataa tcataagtct gtgcaccatc
     7081 tacaaccgga cctttgcaat aagagttcaa cacccatccg atcagcaaag gcacgcccat
     7141 caatccccag ttctgtaccc aaaagatcaa cgcataagcc gttcccaact gtttctccgg
     7201 aataatcttc ggaaccgaag gccacattgc cgaaggaacc aatgagaaag caaatcccag
     7261 aataatcatg atcaccgttg caaaccacca tatattcaga ataggaagag cgaacatcgt
     7321 gtgtacgaaa atcagcatca ccgacccgat caccatcagc gtggctccct taccgatacg
     7381 gtcatacaat gaaccgaaca acggtgtcag gatgatcgcg ccaatcggca gcaatccggg
     7441 aatcgttccc gcaagtttcg gatcaacatt gtacttctgt accatcaaat cggccgcata
     7501 cttgatgaag gggaatacag ccgaatagaa caatacgcac agtaatgcga tcagccagaa
     7561 tcctttgttg gtaatgatat agacaatgtc tttcatgcgg aaaggttctt ccggttccag
     7621 tccttccgca tccagtgaag catccagttt cttatcgtag aaagtataga tgaagaatgc
     7681 gatggtacct acgcacaaca tgacgagaca gaacagaatc ggagcaggaa tattggtatg
     7741 gaatacgccg ctctcatccg tagacccgaa gaagtctgcc aaaggaacgg taagcaccat
     7801 ggccaaagtc gttccattac gcgcggtcgc catttccagt cccatagcga gagccatctc
     7861 tttgccttta aaccacttca cgataatctt cgaaacggtg atacccgcaa tttcgactcc
     7921 tacaccgaaa atagcataac ccaatgcagc caatgtgact tgcatcttga atccgaaaag
     7981 catcgcacct tccgggaaag tagtagtaat agcataatat ttcaatccac aaccgaacac
     8041 catcaataaa caggcaccca ttccggtgaa gcgtactccc atcttatcca gaatgatacc
     8101 accaaagatg agcatcagca ggaatacatt aaaccagcca taagcactgg tgaaaaaacc
     8161 gtaatctaaa ctgtcccaga gaagttcttt ttcaagcatg ggtttcagag gagacataac
     8221 gtctgtgagg aagtagccgc acaacatggt aaaagcgact aatgctagaa cactccaacg
     8281 cagcactgcg gagtcattca gcttttgttt caattgttct gtcattgtaa tatttaaaag
     8341 gagttaataa tctcgtaacg ggcaacaaag ttaactaatt atcatttgtt ttactaaaaa
     8401 aggagaacat tttataagaa aaaggacatc tgaccggata ttcctgtatg aagaagagca
     8461 gaccgggccc aataataaag acagacgcga actacacgta ttacacgatt ctattagaat
     8521 ctcttgtaat tcgcgtaatt cgcgcctata atgaagagaa cgggtcaaaa agcccgttca
     8581 ctcaataagt ttaaaccgaa tatcctgtca ctgaattatt ctgctgcagg agcaggagtt
     8641 tcagtagccg gagcttccgt tgctggtgca gactctgcag gagcagtagc atctgtctga
     8701 ggagcagcag taccggtagg catattatac gggttggttt gttgttcttt ctgtgcttgt
     8761 tccaacaata catctttagc tgcagaagaa gaaggaacaa cgtaagcagt agcaacgctc
     8821 atcacaacca tgaagatagc cagaccccaa gttgcttttt ccagaaaatc tgtagtcttg
     8881 cgcacgccca tgatagcgtt tgatgaagaa aaaccagaag caagtccgcc tccttttgag
     8941 ttctgaatca gcacgatgaa gcacatcagc aaggctgcaa tcaccattaa gataatgaat
     9001 aataagtaca tttttagtta ttttgaatta gcgttaataa tcaatttctc nnnnnnnnnn
     9061 agcatttttt tttggatatt tcaagcttaa ttttttaatt atttcaagag ctttcgaata
     9121 tcgttgctgt tttacgtaga ttttggccaa agtttctgtg aaacagctgt catcttcctc
     9181 ttctatggtg ttggtttcag ttgtttcgtc tgttctgccc gtttcgtttg tttcagcgga
     9241 agaagctgcc tttgctttct cttcttccct caaaggtttc aggtatacga ctggatcagt
     9301 ctcgcttttt tcgataaagt tgtcaatcag ctcgtgtcct ttcagcttgg gcattgcctc
     9361 tgccggctcg tcggcgacag atgtctcttc gagaaggtat gccgtatagt ccatggagta
     9421 atcaaagctt gtctgactgg ttacttcttc gggagccgtc gaaaggaaag catcgatcag
     9481 agccagtgtc cggtcgacgg taggctcatc tttcaatact tcagagagag gcagcccttt
     9541 cttctgggat tcgacagcga agcgttcgcc ttcgatcaga tgaaacagtt tccgtcggtc
     9601 ggcaatatac agaacggctt tccgcagttc cgcaccgaaa ttaatgtcgt ggagaatata
     9661 caggttcttg agatacaaca accggagcga ctgaaaatac ggatacctcg cgagctggtt
     9721 gcgcagttcg tacaaagtat ccctattcag cgtctcggga tgctgaatcc attgttgcaa
     9781 gttaacagaa gtcattaaat taccagtttg ctacagttgc attaaatatt tggtcggtta
     9841 tctctttact catttccgct attaatccat cctgtacggc tgtcagcagc tggctggaat
     9901 cataggtacg gaaagctgag aattgttgtt cgaagtcttc ggcgtgattt gtgttgttga
     9961 caaagcgtac attgaccgtg atggtcagct tcgtttccga agagtaacca tcggcagaca
    10021 ctgcctggtt atactggttg tagcccgtaa tttcaccgtc aatctgcaga tccgcattct
    10081 ggttcggttt cagcagttgc agacgggtct gtctgatgaa gatatctttc aggtcttcat
    10141 tgaacttggt agccagcgga gcatacacat actccgactt aatcgggaaa tcagcaatcg
    10201 aaatagtctt caccttatcg taattgatag aggagccatt aaacttatag gacacactac
    10261 aggcgatgat gactgccggt aaaacaacca atatcagcgg tcgtgctatt ttcttaatcc
    10321 aattcatatt cttttatttt tctgtaaagg gtacgctcgg agatattcag atccttcgcc
    10381 gcacttttcc gcttaccatg atgcctctca agcgctttac gtatcatttc tttttccact
    10441 tcatcgagcg aaagggtttc ttctacatat tcttccgtgt cctgaatatc gtcatcgtct
    10501 tctttgggac aaacagacgg ttgctgcaca gcatggataa tggccggcac ggaaggttgg
    10561 tgcgtcgttg tcactaccgg agtagctact acctgtccca tctgtccgac ttgtcccgca
    10621 cgttcagcca tcatattgtg caccatcttc ttcagttccg ccacttcctg acgcatatcg
    10681 aacaagacag aatatagtat ttcgcgttcg ctctcaaagc tcttgctctc gcgtgtgccg
    10741 aacagtgccg gaaggcgttg ggtattctgt gccggaagat aggtctgcag aatcgcagcc
    10801 gttatctcac ggtttgtttc tataatcgaa atctgctctg tgatgttctt caactgccgg
    10861 acgtttcccg gccacggata agcaagcaat atcttcttgg catcttccgt cagctggata
    10921 gccggcatcc ggtacttttc ggcaaagtct gcggcaaact tacggaacag caacagcaca
    10981 tcgtctccgc gctcacgcaa aggtggtatc tgaataggca ccgtgttcaa ccgataatac
    11041 aaatcttccc gaaagcgtcc ttcggcaatg gcttgtgtca ggttcacgtt ggtagctgcc
    11101 acaatacgta catccgtctt ttgcactttg gatgaaccga ccttgataaa ttcaccgctt
    11161 tcaagtacac ggagcagacg cgcctgtgta ggcaacggca actctcccac ttcatcaagg
    11221 aagatggttc caccgtcagc ttctccaaaa tatcctttcc gctcaccaat agcaccggta
    11281 aatgctcctt tctcgtgtcc gaacagttcg gaatcgatcg taccttccgg tatggcacca
    11341 cagttgacag caatatactg cccatgcttt ctccggctat attgatgaat gatctgtgga
    11401 aaactttctt ttccgacacc actttctccg gtaatcagca cagacaaatc ggtaggagct
    11461 acctgaatgg caacatctat ggcacgtgat aaagcctcgg tattgccaat aataccgaaa
    11521 cgctgtttca cttgttgtat ctccgctttg gtcatctatc ttaatattaa gtaataggta
    11581 ataagtatta agtaataagt attaagtatt accatcatta tcatctcgct tccatccgca
    11641 tggctaatac ttaatactta ttacttaata cctattactt aatcttcgtc tactgtatcc
    11701 agttttagtt tatcactatc gtcccgtttc tcgtaatact gcttccgcaa cgggtttacc
    11761 cgtgccgctt tctcgcgctg gcggttgcgg aatacatcaa tcgctacata aatagcctgg
    11821 cggaaagagt cttcgctggc cagtccttta ccggcgatgt cataggctgt tccatgagcc
    11881 ggagaggtac gtacaaccgg cagtccggcg gtatagttca caccgtcttc catagccagg
    11941 gctttgaacg gagccagtcc ctgatcatga tacatagcaa ggattccgtc aaagtgagta
    12001 taattgcccg aacccataaa accgtccgca gcataaggac cgtaacagat gatccctttc
    12061 tcttccattt ctttcatggc agggataatg atttcctgtt cttccatacc cagcagtccg
    12121 ccgtctcctg catgaggatt cagtgaaagc actgcaatac ggggcgcacc gataccgaaa
    12181 tcctgtttca gacaacgatg gaaaatcatc agcttttcct gaatcagttc cttggtgatt
    12241 gttgtagcaa tctcccttac cggaatatgc gtcgttacta aagccacacg aaaatcgttt
    12301 ttcatcagga tcatcagtga cttgtttcca tcgcccagac gttcttcaat atactccgta
    12361 tgaccgggga aagagaactc
//
